AGPAT2

Summary

Gene Symbol: AGPAT2
Description: 1-acylglycerol-3-phosphate O-acyltransferase 2
Alias: 1-AGPAT2, BSCL, BSCL1, LPAAB, LPAAT-beta, 1-acyl-sn-glycerol-3-phosphate acyltransferase beta, 1-AGP acyltransferase 2, 1-AGPAT 2, 1-acylglycerol-3-phosphate O-acyltransferase 2 (lysophosphatidic acid acyltransferase, beta), lysophosphatidic acid acyltransferase-beta, testicular tissue protein Li 143
Species: human
Products:     AGPAT2

Top Publications

  1. Eberhardt C, Gray P, Tjoelker L. Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3. J Biol Chem. 1997;272:20299-305 pubmed
    ..The human LPAAT gene is contained on six exons that map to chromosome 9, region q34.3. ..
  2. Stamps A, Elmore M, Hill M, Kelly K, Makda A, Finnen M. A human cDNA sequence with homology to non-mammalian lysophosphatidic acid acyltransferases. Biochem J. 1997;326 ( Pt 2):455-61 pubmed
    ..This cDNA therefore represents the first described sequence of a mammalian gene homologous to non-mammalian lysophosphatidic acid acyltransferases. ..
  3. West J, Tompkins C, Balantac N, Nudelman E, Meengs B, White T, et al. Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells. DNA Cell Biol. 1997;16:691-701 pubmed
  4. Agarwal A, Arioglu E, De Almeida S, Akkoc N, Taylor S, Bowcock A, et al. AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. Nat Genet. 2002;31:21-3 pubmed
    ..We report several different mutations of the gene (AGPAT2) encoding 1-acylglycerol-3-phosphate O-acyltransferase 2 in 20 affected individuals from 11 pedigrees of diverse ..
  5. Aguado B, Campbell R. Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex. J Biol Chem. 1998;273:4096-105 pubmed
    ..Due to the known role of LPA and PA in intracellular signaling and inflammation, the hLPAATalpha gene represents a candidate gene for some MHC-associated diseases. ..
  6. Simha V, Garg A. Phenotypic heterogeneity in body fat distribution in patients with congenital generalized lipodystrophy caused by mutations in the AGPAT2 or seipin genes. J Clin Endocrinol Metab. 2003;88:5433-7 pubmed
    ..Recently, we reported mutations in the 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) gene in CGL pedigrees linked to chromosome 9q34 (CGL1 subtype), and mutations in the Seipin gene were reported in ..
  7. Garg A. Acquired and inherited lipodystrophies. N Engl J Med. 2004;350:1220-34 pubmed
  8. Subauste A, Das A, Li X, Elliott B, Elliot B, Evans C, et al. Alterations in lipid signaling underlie lipodystrophy secondary to AGPAT2 mutations. Diabetes. 2012;61:2922-31 pubmed publisher
    Congenital generalized lipodystrophy (CGL), secondary to AGPAT2 mutation is characterized by the absence of adipocytes and development of severe insulin resistance...
  9. Haque W, Garg A, Agarwal A. Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy. Biochem Biophys Res Commun. 2005;327:446-53 pubmed
    Mutations in the gene encoding 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2) have been reported in patients with congenital generalized lipodystrophy (CGL)...

More Information

Publications63

  1. Niesporek S, Denkert C, Weichert W, Kobel M, Noske A, Sehouli J, et al. Expression of lysophosphatidic acid acyltransferase beta (LPAAT-beta) in ovarian carcinoma: correlation with tumour grading and prognosis. Br J Cancer. 2005;92:1729-36 pubmed
    b>Lysophosphatidic acid acyltransferase beta (LPAAT-beta) is an enzyme involved in lipid biosynthesis whose role in tumour progression has been of emerging interest in the last few years...
  2. Rastegar F, Gao J, Shenaq D, Luo Q, Shi Q, Kim S, et al. Lysophosphatidic acid acyltransferase ? (LPAAT?) promotes the tumor growth of human osteosarcoma. PLoS ONE. 2010;5:e14182 pubmed publisher
    ..We sought to investigate the role of lysophosphatidic acid acyltransferase ? (LPAAT?, aka, AGPAT2) in regulating the proliferation and growth of human osteosarcoma cells...
  3. Boutet E, El Mourabit H, Prot M, Nemani M, Khallouf E, Colard O, et al. Seipin deficiency alters fatty acid Delta9 desaturation and lipid droplet formation in Berardinelli-Seip congenital lipodystrophy. Biochimie. 2009;91:796-803 pubmed publisher
    ..in the genes encoding either seipin of unknown function or 1-acyl-glycerol-3-phosphate O-acyltransferase 2 (AGPAT2) which catalyses the formation of phosphatidic acid from lysophosphatidic acid...
  4. Miranda D, Wajchenberg B, Calsolari M, Aguiar M, Silva J, Ribeiro M, et al. Novel mutations of the BSCL2 and AGPAT2 genes in 10 families with Berardinelli-Seip congenital generalized lipodystrophy syndrome. Clin Endocrinol (Oxf). 2009;71:512-7 pubmed publisher
    ..or Berardinelli-Seip syndrome, is a rare autosomal recessive disease caused by mutations in either the BSCL2 or AGPAT2 genes...
  5. Agarwal A, Sukumaran S, Cortés V, Tunison K, Mizrachi D, Sankella S, et al. Human 1-acylglycerol-3-phosphate O-acyltransferase isoforms 1 and 2: biochemical characterization and inability to rescue hepatic steatosis in Agpat2(-/-) gene lipodystrophic mice. J Biol Chem. 2011;286:37676-91 pubmed publisher
    ..b>AGPAT2 generates precursors for the synthesis of glycerophospholipids and triacylglycerols...
  6. Jiao Y, Ahmed U, Sim M, Bejar A, Zhang X, Talukder M, et al. Discovering metabolic disease gene interactions by correlated effects on cellular morphology. Mol Metab. 2019;: pubmed publisher
    ..For two lipodystrophy genes, BSCL2 and AGPAT2, sub-clusters with PLIN1 and CEBPA identifed by morphological similarity were validated by independent experiments ..
  7. Strieder Barboza C, Contreras G. Fetuin-A modulates lipid mobilization in bovine adipose tissue by enhancing lipogenic activity of adipocytes. J Dairy Sci. 2019;102:4628-4638 pubmed publisher
    ..Exposure to FetA upregulated 1-acylglycerol-3-phosphate acyltransferase-2 (AGPAT2) gene expression and protein content, as well as its activity...
  8. Schubert C, Schreckenbach M, Kirmeier T, Gall Kleebach D, Wollweber B, Buell D, et al. PTSD psychotherapy improves blood pressure but leaves HPA axis feedback sensitivity stable and unaffected: First evidence from a pre-post treatment study. Psychoneuroendocrinology. 2019;100:254-263 pubmed publisher
    ..significant elevation in HR and diastolic BP while their systolic BP, DST outcomes and basal serum cortisol levels (BSCL) were not significantly altered...
  9. Liu Y, Li D, DING Y, Kang L, Jin Y, Song J, et al. Further delineation of AGPAT2 and BSCL2 related congenital generalized lipodystrophy in young infants. Eur J Med Genet. 2018;: pubmed publisher
    ..lipodystrophy (CGL) is a rare autosomal recessive disorder with two major subtypes, which are caused by AGPAT2 and BSCL2 mutations...
  10. Yin Z, He X, Zou R. [Unusual facies and recurrent high triglycerides for more than one year in a girl]. Zhongguo Dang Dai Er Ke Za Zhi. 2018;20:1050-1054 pubmed
    ..About 95% of CGL cases are caused by mutations in the AGPAT2 or BSCL2 gene.
  11. Dantas de Medeiros J, Carneiro Bezerra B, Brito de Araújo T, Craveiro Sarmento A, de Azevedo Medeiros L, Peroni Gualdi L, et al. Impairment of respiratory muscle strength in Berardinelli-Seip congenital lipodystrophy subjects. Respir Res. 2018;19:173 pubmed publisher
    Berardinelli-Seip Congenital Generalized Lipodystrophy (BSCL) is an ultra-rare metabolic disease characterized by hypertriglyceridemia, hyperinsulinemia, hyperglycemia, hypoleptinemia, and diabetes mellitus...
  12. Jelani M, Ahmed S, Almramhi M, Mohamoud H, Bakur K, Anshasi W, et al. Novel nonsense mutation in the PTRF gene underlies congenital generalized lipodystrophy in a consanguineous Saudi family. Eur J Med Genet. 2015;58:216-21 pubmed publisher
    ..Four different but overlapping phenotypes (CGL1-4) have been identified, which are caused by mutations in AGPAT2 at 9q34.3, BSCL2 at 11q13, CAV1 at 7q31.1, and PTRF at 17q21.2...
  13. Qin N, Bayat A, Trevisi E, Minuti A, Kairenius P, Viitala S, et al. Dietary supplement of conjugated linoleic acids or polyunsaturated fatty acids suppressed the mobilization of body fat reserves in dairy cows at early lactation through different pathways. J Dairy Sci. 2018;101:7954-7970 pubmed publisher
    ..In conclusion, the CLA and HSO diets induced a shift in energy partitioning toward AT instead of mammary gland during lactation through the regulation of different pathways. ..
  14. Taylor K, Molchan R, Townley J, Caldwell M, Panday V. The effect of silicone hydrogel bandage soft contact lens base curvature on comfort and outcomes after photorefractive keratectomy. Eye Contact Lens. 2015;41:77-83 pubmed publisher
    ..lens loss experienced using two different base curvatures (BCs) of the Acuvue Oasys bandage soft contact lens (BSCL) after photorefractive keratectomy (PRK)...
  15. Triantafyllou E, Georgatsou E, Mylonis I, Simos G, Paraskeva E. Expression of AGPAT2, an enzyme involved in the glycerophospholipid/triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia. Biochim Biophys Acta Mol Cell Biol Lipids. 2018;1863:1142-1152 pubmed publisher
    ..We show that expression of acylglycerol-3-phosphate acyltransferase 2 (AGPAT2), also known as lysophosphatidic acid acyltransferase β (LPAATβ), was upregulated under hypoxia and this was ..
  16. van der Pol R, Benninga M, Magré J, Van Maldergem L, Rotteveel J, van der Knaap M, et al. Berardinelli-Seip syndrome and achalasia: a shared pathomechanism?. Eur J Pediatr. 2015;174:975-80 pubmed publisher
    Berardinelli-Seip congenital lipodystrophy (BSCL) is an uncommon autosomal recessive disorder. Patients with BSCL present with a distinct phenotype since subcutaneous fat is largely lacking and musculature has become more prominent...
  17. Ä°ÅŸlek A, Sayar E, Yılmaz A, Duman Ã, Artan R. A very rare cause of acute pancreatitis: Berardinelli-Seip congenital lipodystrophy. Turk J Gastroenterol. 2014;25 Suppl 1:216-9 pubmed publisher
    ..It is usually presented with a sign of underlying systemic disease. Berardinelli-Seip congenital lipodystrophy (BSCL) is a very rare disease characterized by near absence of adipose tissue resulting in apparent muscle hypertrophy ..
  18. Zhou H, Black S, Benson T, Weintraub N, Chen W. Berardinelli-Seip Congenital Lipodystrophy 2/Seipin Is Not Required for Brown Adipogenesis but Regulates Brown Adipose Tissue Development and Function. Mol Cell Biol. 2016;36:2027-38 pubmed publisher
    ..Berardinelli-Seip congenital lipodystrophy (BSCL) type 2 (BSCL2; also known as seipin) is a lipodystrophy-associated endoplasmic reticulum membrane protein ..
  19. Lima J, Nobrega L, Lima N, Dos Santos M, Baracho M, Bandeira F, et al. Bone Density in Patients With Berardinelli-Seip Congenital Lipodystrophy Is Higher in Trabecular Sites and in Type 2 Patients. J Clin Densitom. 2018;21:61-67 pubmed publisher
    ..There was no significant difference in the Z-scores between males and females. None of type 1 (AGPAT2) patients had Z-scores higher than +2.5 SD, and these patients had a smaller Z-score of BMD total body (0...
  20. Keenan K, Hoffman M, Dullen K, O Brien K. Molecular drivers of mitochondrial membrane proliferation in response to cold acclimation in threespine stickleback. Comp Biochem Physiol A Mol Integr Physiol. 2017;203:109-114 pubmed publisher
    ..diphosphodiacylglycerol synthase-1 (CDS1), CDS2, GPAT1, GPAT2 and 1-acylglycerol 3-phosphate acyltransferase-2 (AGPAT2), were quantified in liver and pectoral muscle of stickleback harvested during cold acclimation...
  21. Lounis M, Lalonde S, Rial S, Bergeron K, Ralston J, Mutch D, et al. Hepatic BSCL2 (Seipin) Deficiency Disrupts Lipid Droplet Homeostasis and Increases Lipid Metabolism via SCD1 Activity. Lipids. 2017;52:129-150 pubmed publisher
    Berardinelli-Seip congenital lipodystrophy (BSCL) is an autosomal recessive disorder. The more severe form, designated BSCL2, arises due to mutations in the BSCL2 gene...
  22. Lima J, Lima N, Nobrega L, Jerônimo S. Conversations between insulin and bone: Potential mechanism of high bone density in patients with Berardinelli-Seip Congenital Lipodystrophy. Med Hypotheses. 2016;97:94-97 pubmed publisher
    Berardinelli-Seip Congenital Lipodystrophy (BSCL) is a rare autosomal recessive syndrome characterized by a difficulty storing lipid in adipocytes, low body fat, hypertriglyceridemia, and fat liver...
  23. Su X, Lin R, Huang Y, Sheng H, Li X, Ting T, et al. Clinical and Mutational Features of Three Chinese Children with Congenital Generalized Lipodystrophy. J Clin Res Pediatr Endocrinol. 2017;9:52-57 pubmed publisher
    ..All coding regions and adjacent exon-intron junction regions of AGPAT2 and BSCL2 genes were amplified by polymerase chain reaction and sequenced...
  24. Cautivo K, Lizama C, Tapia P, Agarwal A, Garg A, Horton J, et al. AGPAT2 is essential for postnatal development and maintenance of white and brown adipose tissue. Mol Metab. 2016;5:491-505 pubmed publisher
    Characterize the cellular and molecular events responsible for lipodystrophy in AGPAT2 deficient mice...
  25. Gibellini L, De Biasi S, Nasi M, Carnevale G, Pisciotta A, Bianchini E, et al. Different origin of adipogenic stem cells influences the response to antiretroviral drugs. Exp Cell Res. 2015;337:160-9 pubmed publisher
    ..fatty acid binding protein-4 (FABP4), perilipin-1 (PLIN1) and 1-acylglycerol-3-phosphate O-acyltransferase-2 (AGPAT2), were quantified by real time PCR...
  26. Huang H, Zhao G, Liu R, Li Q, Zheng M, Li S, et al. Brain Natriuretic Peptide Stimulates Lipid Metabolism through Its Receptor NPR1 and the Glycerolipid Metabolism Pathway in Chicken Adipocytes. Biochemistry. 2015;54:6622-30 pubmed publisher
    ..In conclusion, BNP stimulates the proliferation, differentiation, and lipolysis of preadipocytes through upregulation of the levels of expression of its receptor NPR1 and key genes enriched in the glycerolipid metabolic pathway. ..
  27. Nenadić I, Lamberth S, Reiss N. Group schema therapy for personality disorders: A pilot study for implementation in acute psychiatric in-patient settings. Psychiatry Res. 2017;253:9-12 pubmed publisher
    ..the SMI) and early maladaptive schemas (YSQ-3), as well as overall symptom severity (brief symptom check list, BSCL-53-S), patient satisfaction (ZUF-8) and group climate and coherence (GCQ-S)...
  28. Fernández Galilea M, Tapia P, Cautivo K, Morselli E, Cortés V. AGPAT2 deficiency impairs adipogenic differentiation in primary cultured preadipocytes in a non-autophagy or apoptosis dependent mechanism. Biochem Biophys Res Commun. 2015;467:39-45 pubmed publisher
    Mutations in 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) result in lipodystrophy, insulin resistance and diabetes. Autophagy is required for normal adipogenesis and adipose tissue development...
  29. Wang G, Cline M, Gilbert E. Responses to peripheral neuropeptide Y in avian adipose tissue are diet, depot, and time specific. Gen Comp Endocrinol. 2018;262:12-19 pubmed publisher
    ..2 (NPYR2) mRNA in chicks fed the HP diet and a decrease in 1-acylglycerol-3-phosphate O-acyltransferase 2 (AGPAT2) mRNA in chicks fed the HC diet...
  30. Ramanathan N, Ahmed M, Raffan E, Stewart C, O Rahilly S, Semple R, et al. Identification and Characterisation of a Novel Pathogenic Mutation in the Human Lipodystrophy Gene AGPAT2 : C48R: A Novel Mutation in AGPAT2. JIMD Rep. 2013;9:73-80 pubmed publisher
    Loss-of-function mutations in AGPAT2, encoding 1-acylglycerol-3-phosphate-O-acyltransferase 2 (AGPAT2), produce congenital generalised lipodystrophy (CGL)...
  31. Schrauwen I, Szelinger S, Siniard A, Kurdoglu A, Corneveaux J, Malenica I, et al. A Frame-Shift Mutation in CAV1 Is Associated with a Severe Neonatal Progeroid and Lipodystrophy Syndrome. PLoS ONE. 2015;10:e0131797 pubmed publisher
    ..Indications for this are supported by additional rare variants we found in AGPAT2 and LPIN1 lipodystrophy genes...
  32. Bradley R, Mardian E, Moes K, Duncan R. Acute Fasting Induces Expression of Acylglycerophosphate Acyltransferase (AGPAT) Enzymes in Murine Liver, Heart, and Brain. Lipids. 2017;52:457-461 pubmed publisher
    ..Following fasting, induction of Agpat2, 3, 4, and 5 was observed in the liver, Agpat2 and 3 in heart tissue, and Agpat1, 2, and 3 in whole brain tissue...
  33. Dollet L, Levrel C, Coskun T, Le Lay S, Le May C, Ayer A, et al. FGF21 Improves the Adipocyte Dysfunction Related to Seipin Deficiency. Diabetes. 2016;65:3410-3417 pubmed
    ..Here, we studied its effect on adipocyte dysfunction in the context of Berardinelli-Seip congenital lipodystrophy (BSCL) linked to seipin deficiency...
  34. Bhujel N, Clark H. Case report: Dental management of Berardinelli-Seip congenital lipodystrophy. Eur Arch Paediatr Dent. 2016;17:137-40 pubmed publisher
    ..congenital lipodystrophy (BSCL) is a very rare autosomal recessive condition caused by mutations of the AGPAT2 gene or the BSCL2 gene. BSCL is associated with a number of dental manifestations...
  35. Altay C, Secil M, Demir T, AtIk T, Akinci G, Özdemir Kutbay N, et al. Determining residual adipose tissue characteristics with MRI in patients with various subtypes of lipodystrophy. Diagn Interv Radiol. 2017;23:428-434 pubmed publisher
    ..Despite generalized loss of metabolically active adipose tissue, patients with CGL1 caused by AGPAT2 mutations had a significant amount of residual adipose tissue in the scalp, earlobes, retro-orbital region, and ..
  36. Lima J, Nobrega L, Lima N, Dos Santos M, Baracho M, Winzenrieth R, et al. Normal bone density and trabecular bone score, but high serum sclerostin in congenital generalized lipodystrophy. Bone. 2017;101:21-25 pubmed publisher
    Berardinelli-Seip Congenital Lipodystrophy (BSCL) is a rare autosomal recessive syndrome characterized by a difficulty in storing lipids in adipocytes, low body fat mass, hypoleptinemia, and hyperinsulinemia...
  37. Agarwal A, Tunison K, Dalal J, Yen C, Farese R, Horton J, et al. Mogat1 deletion does not ameliorate hepatic steatosis in lipodystrophic (Agpat2-/-) or obese (ob/ob) mice. J Lipid Res. 2016;57:616-30 pubmed publisher
    ..To test this, we deletedMogat1in theAgpat2(-/-)andob/obgenetic background to generateMogat1(-/-);Agpat2(-/-)andMogat1(-/-);ob/obdouble knockout (DKO) mice...
  38. Teboul Coré S, Rey Jouvin C, Miquel A, Vatier C, Capeau J, Robert J, et al. Bone imaging findings in genetic and acquired lipodystrophic syndromes: an imaging study of 24 cases. Skeletal Radiol. 2016;45:1495-506 pubmed publisher
    ..12/22 familial partial lipodystrophy (FPLD) and 10/22 congenital generalized lipodystrophy (CGL), 8 with AGPAT2-linked CGL1 and 2 with seipin-linked CGL2...
  39. Fu M, Kazlauskaite R, Baracho M, Santos M, Brandao Neto J, Villares S, et al. Mutations in Gng3lg and AGPAT2 in Berardinelli-Seip congenital lipodystrophy and Brunzell syndrome: phenotype variability suggests important modifier effects. J Clin Endocrinol Metab. 2004;89:2916-22 pubmed
    Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder caused by mutations in AGPAT2 and Gng3lg. We screened for mutations in AGPAT2 and Gng3lg in 26 families with CGL and one family with Brunzell syndrome...
  40. Garg A, Wilson R, Barnes R, Arioglu E, Zaidi Z, Gurakan F, et al. A gene for congenital generalized lipodystrophy maps to human chromosome 9q34. J Clin Endocrinol Metab. 1999;84:3390-4 pubmed
    ..Identification of the CGL gene(s) will contribute to our understanding of the adipocyte differentiation and elucidation of the mechanisms of insulin resistance in disorders of adipose tissue. ..
  41. de Azevedo Medeiros L, Cândido Dantas V, Craveiro Sarmento A, Agnez Lima L, Meireles A, Xavier Nobre T, et al. High prevalence of Berardinelli-Seip Congenital Lipodystrophy in Rio Grande do Norte State, Northeast Brazil. Diabetol Metab Syndr. 2017;9:80 pubmed publisher
    Berardinelli-Seip Congenital Lipodystrophy (BSCL) is a rare disease characterized by the almost complete absence of adipose tissue...
  42. Cortés V, Smalley S, Goldenberg D, Lagos C, Hodgson M, Santos J. Divergent metabolic phenotype between two sisters with congenital generalized lipodystrophy due to double AGPAT2 homozygous mutations. a clinical, genetic and in silico study. PLoS ONE. 2014;9:e87173 pubmed publisher
    ..CGL type 1 is the most frequent form and is caused by mutations in AGPAT2. Genetic and clinical studies were performed in two affected sisters of a Chilean family...
  43. Jahnavi S, Poovazhagi V, Mohan V, Bodhini D, Raghupathy P, Amutha A, et al. Clinical and molecular characterization of neonatal diabetes and monogenic syndromic diabetes in Asian Indian children. Clin Genet. 2013;83:439-45 pubmed publisher
    ..syndromic forms of diabetes like Berardinelli Seip syndrome [1-acyl-sn-glycerol-3-phosphate acyltransferase beta (AGPAT2)] and Fanconi Bickel syndrome [solute carrier family 2A2 (SLC2A2)]...
  44. Gomes K, Pardini V, Ferreira A, Fernandes A. Phenotypic heterogeneity in biochemical parameters correlates with mutations in AGPAT2 or Seipin genes among Berardinelli-Seip congenital lipodystrophy patients. J Inherit Metab Dis. 2005;28:1123-31 pubmed
    ..all of the 10 investigated subjects from the southeastern region were homozygous for a 1036 bp deletion in the AGPAT2 gene (BSCL1 locus)...
  45. Solanki M, Patil S, Baweja D, Noorani H, Pk S. Talon cusps, macrodontia, and aberrant tooth morphology in Berardinelli-Seip syndrome. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008;105:e41-7 pubmed
    ..It is well documented in medicine and skin. It is a rare disorder caused by mutations of AGPAT2 gene or BSCL2 gene...
  46. Song L, Duan P, Gan Y, Li P, Zhao C, Xu J, et al. Silencing LPAAT? inhibits tumor growth of cisplatin-resistant human osteosarcoma in vivo and in vitro. Int J Oncol. 2017;50:535-544 pubmed publisher
    ..Our results suggested that LPAAT? may play an important role in osteosarcoma and silencing LPAAT? may be exploited as a novel therapeutic strategy for the clinical management of cisplatin-resistance. ..
  47. Agarwal A, Tunison K, Dalal J, Nagamma S, Hamra F, Sankella S, et al. Metabolic, Reproductive, and Neurologic Abnormalities in Agpat1-Null Mice. Endocrinology. 2017;158:3954-3973 pubmed publisher
    ..PA is a precursor for key phospholipids and diacylglycerol. AGPAT1 and AGPAT2 are highly homologous isoenzymes that are both expressed in adipocytes...
  48. Blaskovich M, Yendluri V, Lawrence H, Lawrence N, Sebti S, Springett G. Lysophosphatidic acid acyltransferase beta regulates mTOR signaling. PLoS ONE. 2013;8:e78632 pubmed publisher
    ..Our results provide support for the hypothesis that PA generated by LPAAT-β regulates mTOR signaling. We discuss the implications of these findings for using LPAAT-β as a therapeutic target. ..
  49. Song L, Yang J, Duan P, Xu J, Luo X, Luo F, et al. MicroRNA-24 inhibits osteosarcoma cell proliferation both in vitro and in vivo by targeting LPAAT?. Arch Biochem Biophys. 2013;535:128-35 pubmed publisher
    ..In conclusion, our study indicates that miR-24 is reduced in osteosarcoma cells, contributing to up-regulation of LPAAT? and resultant osteosarcoma cell proliferation...
  50. Haghighi A, Razzaghy Azar M, Talea A, Sadeghian M, Ellard S, Haghighi A. Identification of a novel nonsense mutation and a missense substitution in the AGPAT2 gene causing congenital generalized lipodystrophy type 1. Eur J Med Genet. 2012;55:620-4 pubmed publisher
    ..CGL type 1 is caused by mutations in gene encoding 1-acylglycerol-3-phosphate O-acyltransferase-2 (AGPAT2)...
  51. Zhan R, Huang H, Wu S, Lin J. [Lysophosphatidic acid acyltransferase ? gene expression in newly diagnosed leukemia patients]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2010;18:1422-6 pubmed
    ..05). It is concluded that the lpaat ? gene overexpression exists in both AML and CML patients. lpaat ? produced by AML cells probably plays an important role in abnormal proliferation and drug-resistance of AML cells. ..
  52. Lloyd E, Gaubatz J, Burns A, Pownall H. Sustained elevations in NEFA induce cyclooxygenase-2 activity and potentiate THP-1 macrophage foam cell formation. Atherosclerosis. 2007;192:49-55 pubmed
  53. Simha V, Agarwal A, Aronin P, Iannaccone S, Garg A. Novel subtype of congenital generalized lipodystrophy associated with muscular weakness and cervical spine instability. Am J Med Genet A. 2008;146A:2318-26 pubmed publisher
    ..Mutations in three genes, 1-acylglycerol 3-phosphate-O-acyltransferase 2 (AGPAT2), Berardinelli Seip Congenital Lipodystrophy 2 (BSCL2), and Caveolin-1 (CAV1) are associated with the three ..