AGFG1

Summary

Gene Symbol: AGFG1
Description: ArfGAP with FG repeats 1
Alias: HRB, RAB, RIP, arf-GAP domain and FG repeat-containing protein 1, HIV-1 Rev-binding protein, Rab, Rev/Rex activation domain-binding protein, arf-GAP domain and FG repeats-containing protein 1, hRIP, Rev interacting protein, nucleoporin-like protein RIP, rev-interacting protein, rev/Rex activation domain-binding protein
Species: human
Products:     AGFG1

Top Publications

  1. Fritz C, Green M. HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs. Curr Biol. 1996;6:848-54 pubmed
    ..We and others have recently reported the cloning of a human protein (hRIP/Rab), that specifically interacts with the effector domain of Rev...
  2. Salcini A, Confalonieri S, Doria M, Santolini E, Tassi E, Minenkova O, et al. Binding specificity and in vivo targets of the EH domain, a novel protein-protein interaction module. Genes Dev. 1997;11:2239-49 pubmed
    ..Among these interactors were the human homolog of NUMB, a developmentally reguated gene of Drosophila, and RAB, the cellular cofactor of the HIV REV protein. We demonstrated coimmunoprecipitation of Eps15 with NUMB and RAB...
  3. Neville M, Stutz F, Lee L, Davis L, Rosbash M. The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export. Curr Biol. 1997;7:767-75 pubmed
    ..Our findings also agree well with current experiments on Crm1p orthologs in Schizosaccharomyces pombe and in vertebrate systems. ..
  4. Doria M, Salcini A, Colombo E, Parslow T, Pelicci P, Di Fiore P. The eps15 homology (EH) domain-based interaction between eps15 and hrb connects the molecular machinery of endocytosis to that of nucleocytosolic transport. J Cell Biol. 1999;147:1379-84 pubmed
    ..The finding that EH-containing proteins bind to Hrb (a cellular cofactor of the Rev protein) and to the related protein Hrbl raised the possibility that the EH network ..
  5. Sánchez Velar N, Udofia E, Yu Z, Zapp M. hRIP, a cellular cofactor for Rev function, promotes release of HIV RNAs from the perinuclear region. Genes Dev. 2004;18:23-34 pubmed
    ..Thus, hRIP is an essential cellular Rev cofactor, which acts at a previously unanticipated step in HIV-1 RNA export: movement of RNAs from the nuclear periphery to the cytoplasm. ..
  6. Schmid E, Ford M, Burtey A, Praefcke G, Peak Chew S, Mills I, et al. Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. PLoS Biol. 2006;4:e262 pubmed
    ..However, proteins such as beta-arrestin (non-visual arrestin) and autosomal recessive hypercholesterolemia protein, which have direct clathrin interactions, will remain in the coated pits with their interacting receptors...
  7. Bogerd H, Fridell R, Madore S, Cullen B. Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins. Cell. 1995;82:485-94 pubmed
    ..The Rev/Rex activation domain-binding (Rab) protein occupies a binding site on HIV-1 Rev that precisely matches that predicted by genetic analysis...
  8. Fritz C, Zapp M, Green M. A human nucleoporin-like protein that specifically interacts with HIV Rev. Nature. 1995;376:530-3 pubmed
    ..Here we report the use of a yeast two-hybrid screen to clone human Rev interacting protein (hRIP), which specifically interacts with the Rev effector domain...
  9. Fridell R, Bogerd H, Cullen B. Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway. Proc Natl Acad Sci U S A. 1996;93:4421-4 pubmed
    ..on the mutationally defined Rev activation domain, which both binds the nucleoporin-like human cellular cofactor Rab/hRIP and also functions as a nuclear export signal...

More Information

Publications130 found, 100 shown here

  1. Stutz F, Izaurralde E, Mattaj I, Rosbash M. A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus. Mol Cell Biol. 1996;16:7144-50 pubmed
    ..The results suggest that Rev and cellular mediators of RNA export can interact with multiple components of the nuclear pore complex during transport, analogous to the proposed mode of action of the nuclear protein import receptor. ..
  2. Eisfeld A, Neumann G, Kawaoka Y. Human immunodeficiency virus rev-binding protein is essential for influenza a virus replication and promotes genome trafficking in late-stage infection. J Virol. 2011;85:9588-98 pubmed publisher
    ..Here, we investigated the role of the cellular human immunodeficiency virus (HIV) Rev-binding protein (HRB), which interacts with influenza virus nuclear export protein (NEP), during the influenza virus life cycle...
  3. Cui G, Sun F, Gao X, Xie K, Zhang C, Liu S, et al. Proteomic analysis of melatonin-mediated osmotic tolerance by improving energy metabolism and autophagy in wheat (Triticum aestivum L.). Planta. 2018;248:69-87 pubmed publisher
    ..role in autophagy, protease expression, and ubiquitin-mediated protein degradation by significantly upregulating rab-related protein, fused signal recognition particle receptor, aspartyl protease, serine protease, ubiquitin-fold ..
  4. Kuwano Y, Nishida K, Kajita K, Satake Y, Akaike Y, Fujita K, et al. Transformer 2β and miR-204 regulate apoptosis through competitive binding to 3' UTR of BCL2 mRNA. Cell Death Differ. 2015;22:815-25 pubmed publisher
    ..RNA immunoprecipitation (RIP) with an anti-Tra2β antibody and microarray analysis identified a subset of Tra2β-associated mRNAs in HCT116 ..
  5. González Juarbe N, Gilley R, Hinojosa C, Bradley K, Kamei A, Gao G, et al. Pore-Forming Toxins Induce Macrophage Necroptosis during Acute Bacterial Pneumonia. PLoS Pathog. 2015;11:e1005337 pubmed publisher
    Necroptosis is a highly pro-inflammatory mode of cell death regulated by RIP (or RIPK)1 and RIP3 kinases and mediated by the effector MLKL...
  6. Pearson J, Giogha C, Mühlen S, Nachbur U, Pham C, Zhang Y, et al. EspL is a bacterial cysteine protease effector that cleaves RHIM proteins to block necroptosis and inflammation. Nat Microbiol. 2017;2:16258 pubmed publisher
    ..protein 1 (ZBP1)/DNA-dependent activator of IFN-regulatory factors (DAI) that contain receptor-interacting protein (RIP) homotypic interaction motifs (RHIM) play a key role in cell death and inflammatory signalling1-3...
  7. Zhang L, Yang Z, Trottier J, Barbier O, Wang L. Long noncoding RNA MEG3 induces cholestatic liver injury by interaction with PTBP1 to facilitate shp mRNA decay. Hepatology. 2017;65:604-615 pubmed publisher
    ..protein 1 (PTBP1) as a MEG3 interacting protein and validated their interaction by RNA immunoprecipitation (RIP)...
  8. Mei J, Tang G, Wang Q, Wen P, Xu M, Cui D, et al. [Role of ash2 (absent, small, or homeotic)-like and Jumonji domain-containing protein 3 on histone methylation of interferon-gamma gene and their associations with vascular damage of Kawasaki disease]. Zhonghua Xin Xue Guan Bing Za Zhi. 2017;45:791-798 pubmed publisher
    ..tumor necrosis factor receptor 1(TNFR1), toll-like receptor 4(TLR4), receptor interacting serine/threonine kinase 1(RIP-1) and myeloid differentiation primary response gene 88(MyD88) in CD4(+) T cells...
  9. Roychowdhury S, McCullough R, Sanz Garcia C, Saikia P, Alkhouri N, Matloob A, et al. Receptor interacting protein 3 protects mice from high-fat diet-induced liver injury. Hepatology. 2016;64:1518-1533 pubmed publisher
    ..Wild-type C57BL/6 and receptor interacting protein (RIP) 3-/- mice were randomized to chow or HFD...
  10. Pagel R, Bär F, Schröder T, Sünderhauf A, Künstner A, Ibrahim S, et al. Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine. FASEB J. 2017;31:4707-4719 pubmed publisher
    ..Receptor-interacting serine/threonine-protein kinase (RIP)-3-mediated intestinal necroptosis was linked to increased mitotic cell cycle arrest via Per1/2-controlled ..
  11. Tan J, Jia L, Shi W, He Q, Zhu L, Yu B. Rab5a?mediated autophagy regulates the phenotype and behavior of vascular smooth muscle cells. Mol Med Rep. 2016;14:4445-4453 pubmed publisher
    Rab5a, a key member of the Rab family of GTPases, was determined to be a regulator of vascular smooth muscle cell (VSMC) proliferation and migration. However, the exact regulatory mechanism remains unclear...
  12. Balasubramaniam S, Riley L, Bratkovic D, Ketteridge D, Manton N, Cowley M, et al. Unique presentation of cutis laxa with Leigh-like syndrome due to ECHS1 deficiency. J Inherit Metab Dis. 2017;40:745-747 pubmed publisher
    ..synthase deficiency; macrocephaly, alopecia, cutis laxa, and scoliosis (MACS) syndrome, due to Ras and Rab interactor 2 (RIN2) mutations; transaldolase deficiency caused by mutations in the transaldolase 1 (TALDO1) gene; ..
  13. Mridha A, Haczeyni F, Yeh M, Haigh W, Ioannou G, Barn V, et al. TLR9 is up-regulated in human and murine NASH: pivotal role in inflammatory recruitment and cell survival. Clin Sci (Lond). 2017;131:2145-2159 pubmed publisher
    ..mice appeared to exhibit more markers of necroptosis [receptor interacting protein kinase (RIP)-1, RIP-3, and mixed lineage kinase domain-like protein (MLKL)] than Wt, and ?25% showed portal foci of ..
  14. Wang C, Saar V, Leung K, Chen L, Wong G. Human amyloid ? peptide and tau co-expression impairs behavior and causes specific gene expression changes in Caenorhabditis elegans. Neurobiol Dis. 2018;109:88-101 pubmed publisher
    ..to the top 60 genes related to human AD confirmed an overlap of 8 genes: patched homolog 1, PTCH1 (ptc-3), the Rab GTPase activating protein, TBC1D16 (tbc-16), the WD repeat and FYVE domain-containing protein 3, WDFY3 (wdfy-3), ..
  15. Lemstrová R, Brynychová V, Hughes D, Hlaváč V, Dvorak P, Doherty J, et al. Dysregulation of KRAS signaling in pancreatic cancer is not associated with KRAS mutations and outcome. Oncol Lett. 2017;14:5980-5988 pubmed publisher
    ..protein kinase 1/V-akt murine thymoma viral oncogene homolog 1, RAL guanine nucleotide exchange factor, Ras and Rab interactor 1/ABL proto-oncogene-1, non-receptor tyrosine kinase, and RAF proto-oncogene serine/threonine-..
  16. Borroto Escuela D, Agnati L, Bechter K, Jansson A, Tarakanov A, Fuxe K. The role of transmitter diffusion and flow versus extracellular vesicles in volume transmission in the brain neural-glial networks. Philos Trans R Soc Lond B Biol Sci. 2015;370: pubmed publisher
    ..Both mainly originate at the soma-dendritic level. They can transfer lipids and proteins, including receptors, Rab GTPases, tetraspanins, cholesterol, sphingolipids and ceramide...
  17. Afonso M, Rodrigues P, Simão A, Ofengeim D, Carvalho T, Amaral J, et al. Activation of necroptosis in human and experimental cholestasis. Cell Death Dis. 2016;7:e2390 pubmed publisher
    ..Necroptosis, a necrotic cell death pathway regulated by receptor-interacting protein (RIP) 3, may mediate cell death and inflammation in the liver...
  18. Zhang L, Cheng H, Yue Y, Li S, Zhang D, He R. TUG1 knockdown ameliorates atherosclerosis via up-regulating the expression of miR-133a target gene FGF1. Cardiovasc Pathol. 2018;33:6-15 pubmed publisher
    ..Luciferase reporter assay combined with RNA immunoprecipitation (RIP) was applied to confirm the interaction between TUG1, miR-133a and FGF1...
  19. Zhang S, Lu Z, Xu Y, Shi H, Liu Y, Rui Y. STEEL participates in fracture healing through upregulating angiogenesis-related genes by recruiting PARP 1. Eur Rev Med Pharmacol Sci. 2018;22:3669-3675 pubmed publisher
    ..The binding condition of STEEL and its interacting proteins were detected by RIP (RNA binding protein immunoprecipitation), and the binding of PARP 1 [poly (ADP-ribose) polymerase 1] with gene ..
  20. Zhang Y, Liu Y, Xiao F, Liu C, Liang X, Chen J, et al. Rab5, Rab7, and Rab11 Are Required for Caveola-Dependent Endocytosis of Classical Swine Fever Virus in Porcine Alveolar Macrophages. J Virol. 2018;92: pubmed publisher
    ..More importantly, the trafficking of CSFV within endosomes controlled by Rab GTPases is unknown in 3D4/21 cells...
  21. Xu L, Chen L, Li F, Zhang R, Li Z, Chen F, et al. Over-expression of the long non-coding RNA HOTTIP inhibits glioma cell growth by BRE. J Exp Clin Cancer Res. 2016;35:162 pubmed
    ..we discovered the underlying mechanism using the Apoptosis PCR 384HT Array, Western blot, RNA immunoprecipitation (RIP) and luciferase reporter assay...
  22. Shi B, Liu C, Zhou J, Wang S, Gao Z, Zhang X, et al. Entry of Classical Swine Fever Virus into PK-15 Cells via a pH-, Dynamin-, and Cholesterol-Dependent, Clathrin-Mediated Endocytic Pathway That Requires Rab5 and Rab7. J Virol. 2016;90:9194-208 pubmed publisher
    ..Importantly, the effect of DN mutants of three Rab proteins that regulate endosomal traffic on CSFV infection was examined...
  23. Niu Y, Ma F, Huang W, Fang S, Li M, Wei T, et al. Long non-coding RNA TUG1 is involved in cell growth and chemoresistance of small cell lung cancer by regulating LIMK2b via EZH2. Mol Cancer. 2017;16:5 pubmed publisher
    ..Chromatin immunoprecipitation (ChIP) and RNA binding protein immunoprecipitation (RIP) were performed to confirm the molecular mechanism of TUG1 involved in cell growth and chemoresistance of small ..
  24. Zhang W, Sun J, Luo J. High Expression of Rab-like 3 (Rabl3) is Associated with Poor Survival of Patients with Non-Small Cell Lung Cancer via Repression of MAPK8/9/10-Mediated Autophagy. Med Sci Monit. 2016;22:1582-8 pubmed
    BACKGROUND Rab-like 3 (Rabl3) is a member of the Rab subfamily of small GTPases which are involved in controlling proliferation and vesicular trafficking...
  25. Hwang M, Cho K, Jeong K, Park Y, Kim J, Yu S, et al. RCP induces Slug expression and cancer cell invasion by stabilizing ?1 integrin. Oncogene. 2017;36:1102-1111 pubmed publisher
    b>Rab coupling protein (RCP)-induced tumor cell migration has been implicated in tumor pathophysiology and patient outcomes...
  26. Wood R, Newton P, Latomanski E, Newton H. Dot/Icm Effector Translocation by Legionella longbeachae Creates a Replicative Vacuole Similar to That of Legionella pneumophila despite Translocation of Distinct Effector Repertoires. Infect Immun. 2015;83:4081-92 pubmed publisher
    ..A β-lactamase assay was employed to demonstrate the translocation of a novel family of proteins, the Rab-like effector (Rle) proteins...
  27. Malmevik J, Petri R, Klussendorf T, Knauff P, Ã…kerblom M, Johansson J, et al. Identification of the miRNA targetome in hippocampal neurons using RIP-seq. Sci Rep. 2015;5:12609 pubmed publisher
    ..These findings greatly enhance our understanding of the miRNA targetome in hippocampal neurons. ..
  28. Jensen M, Jia W, Isaacson K, Schults A, Cappello J, Prestwich G, et al. Silk-elastinlike protein polymers enhance the efficacy of a therapeutic glycosaminoglycan for prophylactic treatment of radiation-induced proctitis. J Control Release. 2017;263:46-56 pubmed publisher
    Radiation-induced proctitis (RIP) is the most common clinical adverse effect for patients receiving radiotherapy as part of the standard course of treatment for ovarian, prostate, colon, and bladder cancers...
  29. Shang L, Ding W, Li N, Liao L, Chen D, Huang J, et al. The effects and regulatory mechanism of RIP3 on RGC-5 necroptosis following elevated hydrostatic pressure. Acta Biochim Biophys Sin (Shanghai). 2017;49:128-137 pubmed publisher
    ..Receptor-interacting protein 3 (RIP3), a member of the RIP family, is an important mediator of the necroptotic pathway...
  30. Gulbranson D, Davis E, Demmitt B, Ouyang Y, Ye Y, Yu H, et al. RABIF/MSS4 is a Rab-stabilizing holdase chaperone required for GLUT4 exocytosis. Proc Natl Acad Sci U S A. 2017;114:E8224-E8233 pubmed publisher
    b>Rab GTPases are switched from their GDP-bound inactive conformation to a GTP-bound active state by guanine nucleotide exchange factors (GEFs)...
  31. Gurung P, Banskota S, Katila N, Gautam J, Kadayat T, Choi D, et al. Ameliorating effect of TI-1-162, a hydroxyindenone derivative, against TNBS-induced rat colitis is mediated through suppression of RIP/ASK-1/MAPK signaling. Eur J Pharmacol. 2018;827:94-102 pubmed publisher
    ..to action mechanism, TI-1-162 did not disturb TNF-α binding to its receptor, but suppressed phosphorylation of RIP-1, ASK-1, JNK and p38, and nuclear translocation of NF-kB and AP-1, which corresponded to down regulation of ..
  32. Li G, Liu L, Sun P, Wu Y, Lei C, Chen X, et al. Physiological profiles associated with ceasing growth of unfertilized eggs produced by unmated queens in the subterranean termite Reticulitermes chinensis. Biol Open. 2016;5:756-63 pubmed publisher
    ..The different expression of three reproductive genes (vtg 1, rab 11 and JHE 1) suggested that they might be involved in the regulation of ovarian and embryonic growth...
  33. Zhang Y, Cheng J, Zhang J, Wu X, Chen F, Ren X, et al. Proteasome inhibitor PS-341 limits macrophage necroptosis by promoting cIAPs-mediated inhibition of RIP1 and RIP3 activation. Biochem Biophys Res Commun. 2016;477:761-767 pubmed publisher
    ..Further evidences demonstrated reduced levels of both RIP1 and RIP 3 upon PS-341 treatment, concomitantly, a more strong association of RIP1 with cIAPs and less with RIP3 was found ..
  34. Shang C, Rouge P, Van Damme E. Ribosome Inactivating Proteins from Rosaceae. Molecules. 2016;21: pubmed publisher
    ..In this study, we report on the RIP sequences found in the genome/transcriptome of several important Rosaceae species, including many economically ..
  35. McGovern F, Sweeney T, Ryan M, Lott S, Campion F, Boland T. An investigation into the effects of maternal supplementation with excess iodine on the mechanisms and impacts of reduced IgG absorption in the lamb postpartum. Br J Nutr. 2017;117:951-963 pubmed publisher
    ..IgG concentration, ileal morphology and the gene expression of THRB and B2M in the ileum and ras-related protein (RAB) RAB25 and the mucin gene (MUC) MUC1 in the duodenum of the lamb postpartum...
  36. Connor M, Pulsifer A, Price C, Abu Kwaik Y, Lawrenz M. Yersinia pestis Requires Host Rab1b for Survival in Macrophages. PLoS Pathog. 2015;11:e1005241 pubmed publisher
    ..However, the mechanisms used by Y. pestis to subvert killing by the macrophage are unknown. Host Rab GTPases are central mediators of vesicular trafficking and are commonly targeted by bacterial pathogens to alter ..
  37. Gao D, Lv A, Li H, Han D, Zhang Y. LncRNA MALAT-1 Elevates HMGB1 to Promote Autophagy Resulting in Inhibition of Tumor Cell Apoptosis in Multiple Myeloma. J Cell Biochem. 2017;118:3341-3348 pubmed publisher
    ..CHX chase assay and RIP analyses were performed to explore the interaction between MALAT-1 and HMGB1 in MM...
  38. Zhang M, Wang S, Fu B, Gao G, Shen Q. Ecological effects and potential risks of the water diversion project in the Heihe River Basin. Sci Total Environ. 2018;619-620:794-803 pubmed publisher
    To curb the severe ecological deterioration in the lower Heihe River Basin (HRB) in northwest China, a water diversion project was initiated in 2000...
  39. Xie B, Chen Q, Chen L, Sheng Y, Wang H, Chen S. The Inactivation of RabGAP Function of AS160 Promotes Lysosomal Degradation of GLUT4 and Causes Postprandial Hyperglycemia and Hyperinsulinemia. Diabetes. 2016;65:3327-3340 pubmed
    The AS160 (Akt substrate of 160 kDa) is a Rab-GTPase activating protein (RabGAP) with several other functional domains, and its deficiency in mice or human patients lowers GLUT4 protein levels and causes severe insulin resistance...
  40. Tzeng H, Wang Y. Rab-mediated vesicle trafficking in cancer. J Biomed Sci. 2016;23:70 pubmed
    A large group of small Rab GTPases which mediate secretory and endosomal membrane transport, as well as autophagosome biogenesis, are essential components of vesicle trafficking machinery...
  41. Hargett S, Walker N, Hussain S, Hoehn K, Keller S. Deletion of the Rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice. Am J Physiol Endocrinol Metab. 2015;309:E233-45 pubmed publisher
    Tbc1d1 is a Rab GTPase-activating protein (GAP) implicated in regulating intracellular retention and cell surface localization of the glucose transporter GLUT4 and thus glucose uptake in a phosphorylation-dependent manner...
  42. Moriwaki K, Balaji S, Bertin J, Gough P, Chan F. Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair. Cell Rep. 2017;18:2441-2451 pubmed publisher
    ..induces necroptosis, a type of regulated necrosis, through its kinase domain and receptor interacting protein (RIP) homotypic interaction motif (RHIM)...
  43. Frémont S, Romet Lemonne G, Houdusse A, Echard A. Emerging roles of MICAL family proteins - from actin oxidation to membrane trafficking during cytokinesis. J Cell Sci. 2017;130:1509-1517 pubmed publisher
    ..findings regarding the emerging role of the MICAL family of oxidoreductases in F-actin disassembly and describe how Rab GTPases regulate their enzymatic activity...
  44. Das S. Importance of an Orchestrate Participation of Each Individual Residue Present at a Catalytic Site. Mol Inform. 2017;: pubmed publisher
    ..Nature has evolved so many enzymes to enhance the slow GTP hydrolysis. Rab GTPases are evolved to regulate vesicle trafficking...
  45. Su Z, Oto J, Wang J, Kimball W, Chenelle C, Kacmarek R, et al. Validation of Respiratory Inductance Plethysmography for Measuring Tidal Volume in Swine. Comp Med. 2015;65:225-31 pubmed
    ..The aim of this study was to validate respiratory inductance plethysmography (RIP) for measuring VT in swine that are comparable in size to adult humans...
  46. Uematsu S, Vandenhove H, Sweeck L, Van Hees M, Wannijn J, Smolders E. Variability of the soil-to-plant radiocaesium transfer factor for Japanese soils predicted with soil and plant properties. J Environ Radioact. 2016;153:51-60 pubmed publisher
    ..were predicted from the potassium concentration in soil solution (mK) and the Radiocaesium Interception Potential (RIP) of the soil using existing mechanistic models...
  47. Majzoub R, Ewert K, Safinya C. Cationic liposome-nucleic acid nanoparticle assemblies with applications in gene delivery and gene silencing. Philos Trans A Math Phys Eng Sci. 2016;374: pubmed publisher
    ..surface-functionalized PEGylated CL-DNA NPs, including fluorescence microscopy colocalization with members of the Rab family of GTPases, which directly reveal interactions with cell membranes and NP pathways...
  48. Lonjon F, Turner M, Henry C, Rengel D, Lohou D, van de Kerkhove Q, et al. Comparative Secretome Analysis of Ralstonia solanacearum Type 3 Secretion-Associated Mutants Reveals a Fine Control of Effector Delivery, Essential for Bacterial Pathogenicity. Mol Cell Proteomics. 2016;15:598-613 pubmed publisher
    ..There were 228 proteins identified, among which a large proportion of type 3 effectors, called Rip (Ralstonia injected proteins)...
  49. Cekay M, Roesler S, Frank T, Knuth A, Eckhardt I, Fulda S. Smac mimetics and type II interferon synergistically induce necroptosis in various cancer cell lines. Cancer Lett. 2017;410:228-237 pubmed publisher
    ..e. receptor-interacting protein (RIP) 1, RIP3 or mixed lineage kinase domain-like pseudokinase (MLKL), significantly protects from BV6/IFNγ-induced ..
  50. Shin D, Na W, Lee J, Kim G, Baek J, Park S, et al. Site-specific monoubiquitination downregulates Rab5 by disrupting effector binding and guanine nucleotide conversion. elife. 2017;6: pubmed publisher
    b>Rab GTPases, which are involved in intracellular trafficking pathways, have recently been reported to be ubiquitinated. However, the functions of ubiquitinated Rab proteins remain unexplored...
  51. Li H, Sun X, Li Z, Yin Q, Pang H, Pan J, et al. LncRNA UCA1 Promotes Mitochondrial Function of Bladder Cancer via the MiR-195/ARL2 Signaling Pathway. Cell Physiol Biochem. 2017;43:2548-2561 pubmed publisher
    ..Dual-luciferase activity assay and RNA immunoprecipitation (RIP) assay were used to verify the relationship between UCA1 and miR-195...
  52. Guo D, Wang Y, Ren K, Han X. Knockdown of LncRNA PVT1 inhibits tumorigenesis in non-small-cell lung cancer by regulating miR-497 expression. Exp Cell Res. 2018;362:172-179 pubmed publisher
    ..RNA immunoprecipitation (RIP) and luciferase reporter assay were performed to confirm whether PVT1 directly interacts with miR-497...
  53. Noyes M, Lederman E, Adams C, Denard P. Triple-Loaded Suture Anchors Versus a Knotless Rip Stop Construct in a Single-Row Rotator Cuff Repair Model. Arthroscopy. 2018;34:1414-1420 pubmed publisher
    To compare the biomechanical properties of single-row repair with triple-loaded (TL) anchor repair versus a knotless rip stop (KRS) repair in a rotator cuff repair model...
  54. Owens J, Sami W. The Role of the Qur'an and Sunnah in Oral Health. J Relig Health. 2016;55:1954-67 pubmed publisher
    ..In gaining more insight into the ways Islamic HRB shape oral health-related practices and outcomes, if at all, we may be better placed to develop a more culturally ..
  55. Di Chiara M, Glaudemans B, Loffing Cueni D, Odermatt A, Al Hasani H, Devuyst O, et al. Rab-GAP TBC1D4 (AS160) is dispensable for the renal control of sodium and water homeostasis but regulates GLUT4 in mouse kidney. Am J Physiol Renal Physiol. 2015;309:F779-90 pubmed publisher
    The Rab GTPase-activating protein TBC1D4 (AS160) controls trafficking of the glucose transporter GLUT4 in adipocytes and skeletal muscle cells...
  56. Sunada M, Goh T, Ueda T, Nakano A. Functional analyses of the plant-specific C-terminal region of VPS9a: the activating factor for RAB5 in Arabidopsis thaliana. J Plant Res. 2016;129:93-102 pubmed publisher
    Recent studies demonstrated that endosomal transport played important roles in various plant functions. The RAB GTPase regulates the tethering and fusion steps of vesicle trafficking to target membranes in each trafficking pathway by ..
  57. Mellouk N, Enninga J. Cytosolic Access of Intracellular Bacterial Pathogens: The Shigella Paradigm. Front Cell Infect Microbiol. 2016;6:35 pubmed publisher
    ..This includes the bacterial subversion of host trafficking regulators, such as the Rab GTPase Rab11...
  58. Lipatova Z, Majumdar U, Segev N. Trs33-Containing TRAPP IV: A Novel Autophagy-Specific Ypt1 GEF. Genetics. 2016;204:1117-1128 pubmed publisher
    Ypt/Rab GTPases, key regulators of intracellular trafficking pathways, are activated by guanine-nucleotide exchange factors (GEFs). Here, we identify a novel GEF complex, TRAPP IV, which regulates Ypt1-mediated autophagy...
  59. Zhao Y, Chen X, Ying Y, Wang K, Dong H, Gao C, et al. Isolation and phylogenetic analysis of three feline calicivirus strains from domestic cats in Jilin Province, China. Arch Virol. 2017;162:2579-2589 pubmed publisher
    ..Sequence analysis revealed that except for strains HRB-SS, WZ-1, XH, 12Q087-1 and 12Q087-5, the 3' untranslated regions (UTRs) of CH-JL2 and CH-JL3 are more than 20 ..
  60. Widjaja I, Rigter A, Jacobino S, van Kuppeveld F, Leenhouts K, Palomo C, et al. Recombinant Soluble Respiratory Syncytial Virus F Protein That Lacks Heptad Repeat B, Contains a GCN4 Trimerization Motif and Is Not Cleaved Displays Prefusion-Like Characteristics. PLoS ONE. 2015;10:e0130829 pubmed publisher
    ..soluble RSV F proteins could be stabilized in a prefusion-like conformation by mutation of heptad repeat B (HRB)...
  61. Guo F, Jiao F, Song Z, Li S, Liu B, Yang H, et al. Regulation of MALAT1 expression by TDP43 controls the migration and invasion of non-small cell lung cancer cells in vitro. Biochem Biophys Res Commun. 2015;465:293-8 pubmed publisher
    ..We also confirm that TDP-43 directly bound to MALAT1 RNA by a RNA immunoprecipitation (RIP) assay and by luciferase reporter activity assay...
  62. Yu X, He S. The interplay between human herpes simplex virus infection and the apoptosis and necroptosis cell death pathways. Virol J. 2016;13:77 pubmed publisher
    ..or RIPK3) has emerged as a central signaling molecule in necroptosis; it is activated via interaction with other RIP homotypic interaction motif (RHIM)-containing proteins such as RIP1 (or RIPK1)...
  63. Nazlamova L, Noble A, Schubert F, McGeehan J, Myers F, Guille M, et al. A newly identified Rab-GDI paralogue has a role in neural development in amphibia. Gene. 2017;599:78-86 pubmed publisher
    ..GDI proteins contribute to vesicle shuttling by regulating the activity of Rab GTPases, controlling their cycling between the inactive cytosol and active membrane bound states...
  64. Torriano S, Erkilic N, Faugère V, Damodar K, Hamel C, Roux A, et al. Pathogenicity of a novel missense variant associated with choroideremia and its impact on gene replacement therapy. Hum Mol Genet. 2017;26:3573-3584 pubmed publisher
    ..CHM encodes REP1, which plays a key role in the prenylation of Rab GTPases...
  65. Lu J, Bera A, Gondi S, Westover K. KRAS Switch Mutants D33E and A59G Crystallize in the State 1 Conformation. Biochemistry. 2017;: pubmed publisher
    ..The 33DPT35 motif is conserved for multiple members of the RAS subfamily, but is not found in RAB, RHO, ARF or G? families suggesting that dynamics mediated by this motif may be important for determining ..
  66. Taylor M, Špírek M, Chaurasiya K, Ward J, Carzaniga R, Yu X, et al. Rad51 Paralogs Remodel Pre-synaptic Rad51 Filaments to Stimulate Homologous Recombination. Cell. 2015;162:271-286 pubmed publisher
    ..To gain insight into Rad51 paralog function, we investigated a heterodimeric Rad51 paralog complex, RFS-1/RIP-1, and uncovered the molecular basis by which Rad51 paralogs promote HR...
  67. Jiang Y, Shan S, Chi L, Zhang G, Gao X, Li H, et al. Methyl methanesulfonate induces necroptosis in human lung adenoma A549 cells through the PIG-3-reactive oxygen species pathway. Tumour Biol. 2016;37:3785-95 pubmed publisher
    ..p53-induced gene 3 (PIG-3), high mobility group box-1 protein (HMGB1), and receptor interaction protein kinase (RIP) but not the apoptosis-associated caspase-3 and caspase-9 proteins...
  68. Chirieleison S, Kertesy S, Abbott D. Synthetic Biology Reveals the Uniqueness of the RIP Kinase Domain. J Immunol. 2016;196:4291-7 pubmed publisher
    The RIP kinases (RIPKs) play an essential role in inflammatory signaling and inflammatory cell death...
  69. Hoeh M, Levine L. Management of Recurrent Ischemic Priapism 2014: A Complex Condition with Devastating Consequences. Sex Med Rev. 2015;3:24-35 pubmed publisher
    The management of recurrent ischemic priapism (RIP) is not clearly defined. Given the rarity of this condition, most treatment options are supported at best by level 3 or 4 evidence...
  70. Wu H, Hu Y, Liu X, Song W, Gong P, Zhang K, et al. LncRNA TRERNA1 Function as an Enhancer of SNAI1 Promotes Gastric Cancer Metastasis by Regulating Epithelial-Mesenchymal Transition. Mol Ther Nucleic Acids. 2017;8:291-299 pubmed publisher
    ..Increased TRERNA1 is positively correlated with lymph node metastasis of GCs. RNA immunoprecipitation (RIP) and chromatin immunoprecipitation (ChIP) assays revealed that TRERNA1 functions as a scaffold to recruit EZH2 to ..
  71. Argenzio E, Moolenaar W. Emerging biological roles of Cl- intracellular channel proteins. J Cell Sci. 2016;129:4165-4174 pubmed
    ..dynamics as well as vesicular trafficking and integrin recycling, the latter of which are under the control of Rab GTPases...
  72. Casanova J, Winckler B. A new Rab7 effector controls phosphoinositide conversion in endosome maturation. J Cell Biol. 2017;216:2995-2997 pubmed publisher
    Endosome maturation requires a coordinated change in the Rab GTPase and phosphoinositide composition of the endosomal membrane. In this issue, Liu et al. (2017. J. Cell Biol. https://doi.org/10.1083/jcb...
  73. Majumdar S, Acharya A, Prakash B. Structural plasticity mediates distinct GAP-dependent GTP hydrolysis mechanisms in Rab33 and Rab5. FEBS J. 2017;284:4358-4375 pubmed publisher
    ..As the cis-Gln encounters a steric clash, the Rab GTPases employ the so-called dual finger mechanism where the interacting GAP supplies a trans-Gln for catalysis...
  74. Lin Y, Tan K, Liu J, Kong X, Huang Z, Xu X. Global profiling of Rbm24 bound RNAs uncovers a multi-tasking RNA binding protein. Int J Biochem Cell Biol. 2018;94:10-21 pubmed publisher
    ..Here, by performing RNA Immunoprecipitation and coupling it to microarrays (RIP-Chip), we have generated an atlas of the mRNA binding repertoire of Rbm24...
  75. Zhao L, Mukherjee S, Narayan O. Biochemical mechanism of HIV-I Vpr function. Specific interaction with a cellular protein. J Biol Chem. 1994;269:15577-82 pubmed
    ..assay, the purified Vpr interacted specifically with a cellular protein designated as Vpr-interacting protein, or RIP. Mutational analysis suggested that this interaction required a domain rich in leucine/isoleucine residues and ..
  76. Jones T, Sheer D, Bevec D, Kappel B, Hauber J, Steinkasserer A. The human HIV-1 Rev binding-protein hRIP/Rab (HRB) maps to chromosome 2q36. Genomics. 1997;40:198-9 pubmed
  77. Zhan L, Chen S, Li K, Liang D, Zhu X, Liu L, et al. Autophagosome maturation mediated by Rab7 contributes to neuroprotection of hypoxic preconditioning against global cerebral ischemia in rats. Cell Death Dis. 2017;8:e2949 pubmed publisher
    Autophagy disruption leads to neuronal damage in hypoxic-ischemic brain injury. Rab7, a member of the Rab GTPase superfamily, has a unique role in the regulation of autophagy...
  78. Dempsey P. Role of ADAM10 in intestinal crypt homeostasis and tumorigenesis. Biochim Biophys Acta Mol Cell Res. 2017;1864:2228-2239 pubmed publisher
    ..can also modulate other cellular signaling events through a process known as regulated intramembrane proteolysis (RIP)...
  79. Cai J, Wang D, Bai Z, Yin J, Zhang J, Zhang Z. The long noncoding RNA XIAP-AS1 promotes XIAP transcription by XIAP-AS1 interacting with Sp1 in gastric cancer cells. PLoS ONE. 2017;12:e0182433 pubmed publisher
    ..After various XIAP-AS1 deletion mutants were expressed, RIP assays showed that only the full-length XIAP-AS1 RNA interacted with Sp1 and thereby participated in XIAP ..
  80. Liu K, Xing R, Jian Y, Gao Z, Ma X, Sun X, et al. WDR91 is a Rab7 effector required for neuronal development. J Cell Biol. 2017;216:3307-3321 pubmed publisher
    ..PtdIns(3,5)P2 In this study, we identify the WD40-repeat protein WDR91 as a Rab7 effector that couples Rab switching with PtdIns3P down-regulation on endosomes...
  81. Taglauer E, Artemiuk P, Hanscom S, Lindsay A, Wuebbolt D, Breathnach F, et al. Rab11 family expression in the human placenta: Localization at the maternal-fetal interface. PLoS ONE. 2017;12:e0184864 pubmed publisher
    b>Rab proteins are a family of small GTPases involved in a variety of cellular processes. The Rab11 subfamily in particular directs key steps of intracellular functions involving vesicle trafficking of the endosomal recycling pathway...
  82. Theret L, Jeanne A, Langlois B, Hachet C, David M, Khrestchatisky M, et al. Identification of LRP-1 as an endocytosis and recycling receptor for ?1-integrin in thyroid cancer cells. Oncotarget. 2017;8:78614-78632 pubmed publisher
    ..affect the levels of ?1-integrin-containing lysosomes while decreasing localization of ?1-integrin within Rab-11 positive vesicles...
  83. Luo X, Li C, Tan R, Xu X, Wu W, Satoh A, et al. A RasGAP, DAB2IP, regulates lipid droplet homeostasis by serving as GAP toward RAB40C. Oncotarget. 2017;8:85415-85427 pubmed publisher
    Lipid droplet (LD) homeostasis involves activities of various RAB small GTPases. Recently, we found RAB40C was one of the RAB proteins regulating LD homeostasis. RAB40C contains a unique SOCS domain that is required for clustering of LDs...
  84. Muszewska A, Steczkiewicz K, Stepniewska Dziubinska M, Ginalski K. Cut-and-paste transposons in fungi with diverse lifestyles. Genome Biol Evol. 2017;: pubmed publisher
    ..Lastly, we found that fungi with both RIP and RNAi systems have more total DNA TE sequences but less elements retaining a functional transposase, what ..
  85. Mukherjee I, Barlowe C. Overexpression of Sly41 suppresses COPII vesicle-tethering deficiencies by elevating intracellular calcium levels. Mol Biol Cell. 2016;27:1635-49 pubmed publisher
    SLY41 was identified as a multicopy suppressor of loss of Ypt1, a Rab GTPase essential for COPII vesicle tethering at the Golgi complex...
  86. Pylypenko O, Welz T, Tittel J, Kollmar M, Chardon F, Malherbe G, et al. Coordinated recruitment of Spir actin nucleators and myosin V motors to Rab11 vesicle membranes. elife. 2016;5: pubmed publisher
    ..Since MyoV binds several Rab GTPases, synchronized nucleator and motor targeting could provide a common mechanism to control force generation ..
  87. Chauhan A, Min K, Kwon T. RIP1-dependent reactive oxygen species production executes artesunate-induced cell death in renal carcinoma Caki cells. Mol Cell Biochem. 2017;435:15-24 pubmed publisher
    ..On the other hand, necrostatin-1 pretreatment and knockdown of RIP-1 significantly reduced the cytotoxicity of artesunate against Caki cell...
  88. Zhang Z, Ma F, Zhang H, Xu X. MARCKS is Necessary for Oligodendrocyte Precursor Cell Maturation. Neurochem Res. 2017;42:2933-2939 pubmed publisher
    ..Since myristoylated alanine-rich C-kinase substrate (MARCKS) reportedly contributes to Ras-associated protein (Rab)-10-associated vesicle insertion into neuronal membranes, we investigated the role of MARCKS in OPC maturation...
  89. Ku B, You J, Oh K, Yun H, Lee H, Shin H, et al. Crystal structures of two forms of the Acanthamoeba polyphaga mimivirus Rab GTPase. Arch Virol. 2017;162:3407-3416 pubmed publisher
    ..The R214 gene of the APMV genome was recently shown to encode a homologue of the Rab GTPases, molecular switch proteins known to play a pivotal role in the regulation of membrane trafficking that were ..
  90. Lu L, Madugula V. Mechanisms of ciliary targeting: entering importins and Rabs. Cell Mol Life Sci. 2018;75:597-606 pubmed publisher
    ..Based on recent discoveries, we propose a Rab-importin-based model in an attempt to accommodate various observations on ciliary targeting.
  91. Park K, Jang S, Lee J, Lee S, Kikuchi Y, Seo Y, et al. The roles of antimicrobial peptide, rip-thanatin, in the midgut of Riptortus pedestris. Dev Comp Immunol. 2018;78:83-90 pubmed publisher
    Recently, we have reported the structural determination of antimicrobial peptides (AMPs), such as riptocin, rip-defensin, and rip-thanatin, from Riptortus pedestris. However, the biological roles of AMPs in the host midgut remain elusive...
  92. Zhou F, Zou S, Chen Y, Lipatova Z, Sun D, Zhu X, et al. A Rab5 GTPase module is important for autophagosome closure. PLoS Genet. 2017;13:e1007020 pubmed publisher
    ..b>Rab GTPases, which regulate all intracellular trafficking pathways in eukaryotes, also regulate autophagy...