ADRB1

Summary

Gene Symbol: ADRB1
Description: adrenoceptor beta 1
Alias: ADRB1R, B1AR, BETA1AR, RHR, beta-1 adrenergic receptor, adrenergic, beta-1-, receptor, beta-1 adrenoceptor, beta-1 adrenoreceptor
Species: human
Products:     ADRB1

Top Publications

  1. White H, de Boer R, Maqbool A, Greenwood D, van Veldhuisen D, Cuthbert R, et al. An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals with heart failure: a MERIT-HF sub-study. Eur J Heart Fail. 2003;5:463-8 pubmed
    The Glycine389 variant of the beta-1 adrenergic receptor (beta1AR) generates markedly less cAMP when stimulated in vitro than the more prevalent Arginine389 variant...
  2. Small K, Mialet Perez J, Liggett S. Genetic variation within the beta1-adrenergic receptor gene results in haplotype-specific expression phenotypes. J Cardiovasc Pharmacol. 2008;51:106-10 pubmed publisher
    Cardiac beta1-adrenergic receptor (beta1AR) responsiveness in heart failure exhibits interindividual variation that may be attributable to polymorphisms of the intronless beta1AR gene...
  3. Swan L, Birnie D, Padmanabhan S, Inglis G, Connell J, Hillis W. The genetic determination of left ventricular mass in healthy adults. Eur Heart J. 2003;24:577-82 pubmed
    ..Within a normal population left ventricular mass has a significant genetic determination. Further investigation of potential candidate genes is required. ..
  4. Borgel J, Schulz T, Bartels N, Epplen J, Büchner N, Rump L, et al. Modifying effects of the R389G beta1-adrenoceptor polymorphism on resting heart rate and blood pressure in patients with obstructive sleep apnoea. Clin Sci (Lond). 2006;110:117-23 pubmed
    ..In conclusion, although the R389G polymorphism of the beta1-adrenoceptor gene did not influence resting HR or BP in untreated OSA patients, it may modify the beneficial effects of CPAP therapy on these parameters. ..
  5. Iwai C, Akita H, Kanazawa K, Shiga N, Terashima M, Matsuda Y, et al. Arg389Gly polymorphism of the human beta1-adrenergic receptor in patients with nonfatal acute myocardial infarction. Am Heart J. 2003;146:106-9 pubmed
    We sought to investigate the relation between the Arg389Gly polymorphism in the human beta1-adrenergic receptor (ADRB1) gene and acute myocardial infarction (AMI)...
  6. Woodiwiss A, Badenhorst D, Sliwa K, Brooksbank R, Essop R, Sareli P, et al. Beta1- and alpha2c-adrenoreceptor variants as predictors of clinical aspects of dilated cardiomyopathy in people of African ancestry. Cardiovasc J Afr. 2008;19:188-93 pubmed
    ..In patients homozygous for the risk allele of the alpha2c-AR variant, the beta1-AR variant neither increased the risk for IDC nor predicted its severity or progression in patients not receiving beta-AR-blockers. ..
  7. Forleo C, Resta N, Sorrentino S, Guida P, Manghisi A, De Luca V, et al. Association of beta-adrenergic receptor polymorphisms and progression to heart failure in patients with idiopathic dilated cardiomyopathy. Am J Med. 2004;117:451-8 pubmed
  8. Hoehe M, Otterud B, Hsieh W, Martinez M, Stauffer D, Holik J, et al. Genetic mapping of adrenergic receptor genes in humans. J Mol Med (Berl). 1995;73:299-306 pubmed
    ..mapped to the interval between D4S126 and D4S62; and the alpha 2-C10 (alpha 2A AR)/beta 1 haplotype (loci ADRA2A/ADRB1) mapped to the interval between D10S259 and D10S187...
  9. Stanton T, Inglis G, Padmanabhan S, Dominiczak A, Jardine A, Connell J. Variation at the beta-1 adrenoceptor gene locus affects left ventricular mass in renal failure. J Nephrol. 2002;15:512-8 pubmed
    To examine the relationship between this variation in the beta1AR gene and the effect on LV mass. Left ventricular (LV) mass is an important cardiovascular risk factor...

More Information

Publications69

  1. Chen L, Meyers D, Javorsky G, Burstow D, Lolekha P, Lucas M, et al. Arg389Gly-beta1-adrenergic receptors determine improvement in left ventricular systolic function in nonischemic cardiomyopathy patients with heart failure after chronic treatment with carvedilol. Pharmacogenet Genomics. 2007;17:941-9 pubmed
    ..05). In patients with nonischemic dilated cardiomyopathy, carvedilol leads to a significantly greater improvement in LVEF in patients with the Arg389Arg-beta1 adrenergic receptor phenotype. ..
  2. Muthumala A, Drenos F, Elliott P, Humphries S. Role of beta adrenergic receptor polymorphisms in heart failure: systematic review and meta-analysis. Eur J Heart Fail. 2008;10:3-13 pubmed
    ..In addition, a meta-analysis of three studies analysing the effect of ADRB1 Arg389Gly polymorphism on left ventricular remodelling with the use of beta blockers, demonstrating a 5% ..
  3. Wang L, Lu L, Zhang F, Chen Q, Shen W. Polymorphisms of beta-adrenoceptor and natriuretic peptide receptor genes influence the susceptibility to and the severity of idiopathic dilated cardiomyopathy in a Chinese cohort. J Card Fail. 2010;16:36-44 pubmed publisher
    ..This study suggests that NPR2-T2077 and beta1-Gly49 polymorphisms may be genetically synergistic adverse factors for the susceptibility to or the severity of IDCM. ..
  4. Liggett S, Mialet Perez J, Thaneemit Chen S, Weber S, Greene S, Hodne D, et al. A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure. Proc Natl Acad Sci U S A. 2006;103:11288-93 pubmed
    ..We conclude that beta(1)AR-389 variation alters signaling in multiple models and affects the beta-blocker therapeutic response in HF and, thus, might be used to individualize treatment of the syndrome. ..
  5. Nieminen T, Lehtimaki T, Laiho J, Rontu R, Niemela K, Koobi T, et al. Effects of polymorphisms in beta1-adrenoceptor and alpha-subunit of G protein on heart rate and blood pressure during exercise test. The Finnish Cardiovascular Study. J Appl Physiol (1985). 2006;100:507-11 pubmed
    We tested whether the Arg389Gly and Ser49Gly polymorphisms of the beta1-adrenergic receptor gene ADRB1 and the T393C polymorphism of the G protein alpha-subunit gene GNAS1 modulate heart rate (HR) and blood pressure responses during an ..
  6. Kaye D, Smirk B, Finch S, Williams C, Esler M. Interaction between cardiac sympathetic drive and heart rate in heart failure: modulation by adrenergic receptor genotype. J Am Coll Cardiol. 2004;44:2008-15 pubmed
  7. Mao Y, Liu Z, Chen B, Guo D, Han C, Yang L, et al. Effect of 393T>C polymorphism of GNAS1 gene on dobutamine response in Chinese healthy subjects. J Clin Pharmacol. 2009;49:929-36 pubmed publisher
    ..9% +/- 4.0% vs 36.4% +/- 2.1%; 95% CI, 18.8%-38.9%; P = .046). These data suggested that the 393T>C polymorphism of GNAS1 was functionally relevant in vivo. ..
  8. Metra M, Covolo L, Pezzali N, Zaca V, Bugatti S, Lombardi C, et al. Role of beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade with carvedilol in patients with chronic heart failure. Cardiovasc Drugs Ther. 2010;24:49-60 pubmed publisher
    ..Beta1-AR Arg389Gly and beta2-AR Arg16Gly SNPs are not related to the response to carvedilol therapy. In contrast, the Gln27Glu SNP is a determinant of the LVEF response to this agent in patients with chronic HF. ..
  9. Nonen S, Okamoto H, Akino M, Matsui Y, Fujio Y, Yoshiyama M, et al. No positive association between adrenergic receptor variants of alpha2cDel322-325, beta1Ser49, beta1Arg389 and the risk for heart failure in the Japanese population. Br J Clin Pharmacol. 2005;60:414-7 pubmed
    ..In this population, the variants beta(1)Ser49, beta(1)Arg389, and alpha(2c)Del322-325 do not appear to be risk factors for chronic heart failure due to DCM. The alpha(2c)Del322-325 variant may in fact confer some protection. ..
  10. Small K, Wagoner L, Levin A, Kardia S, Liggett S. Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure. N Engl J Med. 2002;347:1135-42 pubmed
    ..Genotyping at these two loci may be a useful approach for identification of persons at risk for heart failure or its progression, who may be candidates for early preventive measures. ..
  11. Paczkowska A, Szperl M, Małek Ł, Mazurkiewicz Ł, Skóra E, Grzybowski J, et al. Polymorphisms of the beta-1 and beta-2 adrenergic receptors in Polish patients with idiopathic dilated cardiomyopathy. Kardiol Pol. 2009;67:235-41 pubmed
    ..Our data showed that the studied beta-adrenergic receptor polymorphisms did not seem to play a significant role in IDCM in the Polish population. ..
  12. Bengtsson K, Melander O, Orho Melander M, Lindblad U, Ranstam J, Rastam L, et al. Polymorphism in the beta(1)-adrenergic receptor gene and hypertension. Circulation. 2001;104:187-90 pubmed
    ..The Ser49Gly polymorphism was not associated with hypertension. Our data suggest that individuals homozygous for the Arg389 allele of the beta(1)-adrenergic receptor gene are at increased risk to develop hypertension. ..
  13. de Groote P, Helbecque N, Lamblin N, Hermant X, Mc Fadden E, Foucher Hossein C, et al. Association between beta-1 and beta-2 adrenergic receptor gene polymorphisms and the response to beta-blockade in patients with stable congestive heart failure. Pharmacogenet Genomics. 2005;15:137-42 pubmed
    ..Heart rate and LVEF responses to beta-blockade were not associated with the beta1AR or the beta2AR polymorphisms...
  14. Fragoso J, Rodriguez Perez J, Gonzalez J, Cruz D, Pérez Méndez O, de Jesus García J, et al. Beta1-adrenergic receptor gene polymorphisms in Mexican patients with idiopathic dilated cardiomyopathy. Exp Mol Pathol. 2006;80:279-82 pubmed
    ..16) and *Arg/*Gly genotype (pC = 0.027, OR = 2.70) in the group of IDC patients when compared to healthy controls. The data suggest that Arg389Gly polymorphism could be involved in the genetic susceptibility to develop IDC in Mexicans. ..
  15. Liu J, Liu Z, Tan Z, Chen X, Wang L, Zhou G, et al. Gly389Arg polymorphism of beta1-adrenergic receptor is associated with the cardiovascular response to metoprolol. Clin Pharmacol Ther. 2003;74:372-9 pubmed
    ..These data suggested that the beta(1)-adrenergic receptor Gly389Arg polymorphism is of major functional importance in vivo. ..
  16. Banas A, Płońska E, Kurzawski M, Gornik W, Drozdzik M. Effect of the ADRB1 1165C>G and 145A>G polymorphisms on hemodynamic response during dobutamine stress echocardiography. Eur J Clin Pharmacol. 2011;67:477-82 pubmed publisher
    The aim of this study was to determine an association between the ADRB1 1165C>G and 145A>G polymorphisms and hemodynamic response [heart rate (HR), systolic (SBP) and diastolic (DBP) blood pressure] to dobutamine during dobutamine ..
  17. Mialet Perez J, Rathz D, Petrashevskaya N, Hahn H, Wagoner L, Schwartz A, et al. Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure. Nat Med. 2003;9:1300-5 pubmed
  18. White H, Maqbool A, McMahon A, Yates L, Ball S, Hall A, et al. An evaluation of the beta-1 adrenergic receptor Arg389Gly polymorphism in individuals at risk of coronary events. A WOSCOPS substudy. Eur Heart J. 2002;23:1087-92 pubmed
    ..We identified the genotype at position 389 of the beta1AR in 1554 individuals taken from men enrolled in the West of Scotland Coronary Prevention Study...
  19. Aquilante C, Yarandi H, Cavallari L, Andrisin T, Terra S, Lewis J, et al. Beta-adrenergic receptor gene polymorphisms and hemodynamic response to dobutamine during dobutamine stress echocardiography. Pharmacogenomics J. 2008;8:408-15 pubmed publisher
    ..These data suggest that the four selected beta(1)- and beta(2)-AR polymorphisms do not substantially influence the magnitude of hemodynamic response to dobutamine during DSE. ..
  20. La Rosee K, Huntgeburth M, Rosenkranz S, Bohm M, Schnabel P. The Arg389Gly beta1-adrenoceptor gene polymorphism determines contractile response to catecholamines. Pharmacogenetics. 2004;14:711-6 pubmed
    Recently, the Arg389Gly beta1-adrenoceptor (beta1AR) gene polymorphism has been detected. The Arg variant exhibited increased responsiveness to agonist-induced stimulation in vitro...
  21. Gjesing A, Andersen G, Albrechtsen A, Glumer C, Borch Johnsen K, Jørgensen T, et al. Studies of associations between the Arg389Gly polymorphism of the beta1-adrenergic receptor gene (ADRB1) and hypertension and obesity in 7677 Danish white subjects. Diabet Med. 2007;24:392-7 pubmed
    Activation of the beta(1)-adrenergic receptor (ADRB1) causes increased lipolysis in adipose tissue and enhances cardiac output...
  22. Biolo A, Clausell N, Santos K, Salvaro R, Ashton Prolla P, Borges A, et al. Impact of beta1-adrenergic receptor polymorphisms on susceptibility to heart failure, arrhythmogenesis, prognosis, and response to beta-blocker therapy. Am J Cardiol. 2008;102:726-32 pubmed publisher
    ..A pharmacogenetic interaction is suggested because beta blockers were more effective in beta1-389Arg allele carriers. ..
  23. Terra S, McGorray S, Wu R, McNamara D, Cavallari L, Walker J, et al. Association between beta-adrenergic receptor polymorphisms and their G-protein-coupled receptors with body mass index and obesity in women: a report from the NHLBI-sponsored WISE study. Int J Obes (Lond). 2005;29:746-54 pubmed
    ..Objective is to determine the association between obesity and polymorphisms in genes of the beta(1)AR (ADRB1), beta(2)AR (ADRB2), beta(3)AR (ADRB3), Gs protein alpha (GNAS1), to which all three beta-receptors couple and the ..
  24. Ranade K, Jorgenson E, Sheu W, Pei D, Hsiung C, Chiang F, et al. A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate. Am J Hum Genet. 2002;70:935-42 pubmed
    ..Neither the Arg389Gly polymorphism in the beta1 adrenergic receptor nor polymorphisms in the beta2 and beta3 adrenergic receptors were associated with resting heart rate. The heritability of heart rate was 39.7% +/- 7.1% (P<10-7). ..
  25. Meyers K, Mosley T, Fox E, Boerwinkle E, Arnett D, Devereux R, et al. Genetic variations associated with echocardiographic left ventricular traits in hypertensive blacks. Hypertension. 2007;49:992-9 pubmed
    ..One in the ADRB1 gene was significantly associated with relative wall thickness with replicate effects in both samples...
  26. Shin J, Lobmeyer M, Gong Y, Zineh I, Langaee T, Yarandi H, et al. Relation of beta(2)-adrenoceptor haplotype to risk of death and heart transplantation in patients with heart failure. Am J Cardiol. 2007;99:250-5 pubmed
    ..Eight polymorphisms in 6 genes were genotyped: beta(1)-adrenergic receptor (ADRB1, S49G, R389G), beta(2)-adrenergic receptor (ADRB2, G16R, Q27E), alpha(2c)-adrenergic receptor (ADRA2C, insertion/..
  27. Wenzel Seifert K, Liu H, Seifert R. Similarities and differences in the coupling of human beta1- and beta2-adrenoceptors to Gs(alpha) splice variants. Biochem Pharmacol. 2002;64:9-20 pubmed
    The human beta1-adrenoceptor (beta1AR) and beta2-adrenoceptor (beta2AR) couple to Gs-proteins to activate adenylyl cyclase (AC)...
  28. Podlowski S, Wenzel K, Luther H, Muller J, Bramlage P, Baumann G, et al. Beta1-adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?. J Mol Med (Berl). 2000;78:87-93 pubmed
    ..The present results may provide a clue on the molecular mechanisms involved in IDCM, and add moreover interesting information on nature, distribution, and evolutionary aspects of sequence variation in human adrenergic receptor genes. ..
  29. Zill P, Baghai T, Engel R, Zwanzger P, Schule C, Minov C, et al. Beta-1-adrenergic receptor gene in major depression: influence on antidepressant treatment response. Am J Med Genet B Neuropsychiatr Genet. 2003;120B:85-9 pubmed
    ..However, after correction for multiple testing (Bonferroni) these results did not remain significant. Nevertheless, these findings suggest that the presence of the C allele might be an indicator for antidepressant treatment response. ..
  30. Frielle T, Collins S, Daniel K, Caron M, Lefkowitz R, Kobilka B. Cloning of the cDNA for the human beta 1-adrenergic receptor. Proc Natl Acad Sci U S A. 1987;84:7920-4 pubmed
    ..Mammalian beta 1AR and beta 2AR are thus products of distinct genes, both of which are apparently related to the putative G-21 receptor. ..
  31. Leineweber K, Frey U, Tenderich G, Toliat M, Zittermann A, Nurnberg P, et al. The Arg16Gly-?(2)-adrenoceptor single nucleotide polymorphism: exercise capacity and survival in patients with end-stage heart failure. Naunyn Schmiedebergs Arch Pharmacol. 2010;382:357-65 pubmed publisher
    ..In conclusion, the Arg16Gly-?(2)AR might impact on exercise capacity and outcome in end-stage heart failure. ..
  32. Moore J, Mason D, Green S, Hsu J, Liggett S. Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C. Hum Mutat. 1999;14:271 pubmed
  33. Johnson J, Zineh I, Puckett B, McGorray S, Yarandi H, Pauly D. Beta 1-adrenergic receptor polymorphisms and antihypertensive response to metoprolol. Clin Pharmacol Ther. 2003;74:44-52 pubmed
    ..We tested the hypothesis that 2 common polymorphisms in the gene for beta(1)-adrenergic receptor are associated with antihypertensive response to metoprolol in patients with uncomplicated hypertension...
  34. Sofowora G, Dishy V, Muszkat M, Xie H, Kim R, Harris P, et al. A common beta1-adrenergic receptor polymorphism (Arg389Gly) affects blood pressure response to beta-blockade. Clin Pharmacol Ther. 2003;73:366-71 pubmed
    ..There is reduced sensitivity of Gly389 homozygotes to a beta-adrenergic receptor antagonist, and this polymorphism may be an important determinant of variability in response to beta-blockade. ..
  35. de Groote P, Lamblin N, Helbecque N, Mouquet F, Mc Fadden E, Hermant X, et al. The impact of beta-adrenoreceptor gene polymorphisms on survival in patients with congestive heart failure. Eur J Heart Fail. 2005;7:966-73 pubmed
    ..There was no statistically significant differences between baseline characteristics among beta1AR and beta2AR genotypes...
  36. Magnusson Y, Levin M, Eggertsen R, Nystrom E, Mobini R, Schaufelberger M, et al. Ser49Gly of beta1-adrenergic receptor is associated with effective beta-blocker dose in dilated cardiomyopathy. Clin Pharmacol Ther. 2005;78:221-31 pubmed
    ..The more common Ser49Ser genotype responded less beneficially to beta-blockade and would motivate genotyping to promote higher doses for the best outcome effect. ..
  37. Wilk J, Myers R, Pankow J, Hunt S, Leppert M, Freedman B, et al. Adrenergic receptor polymorphisms associated with resting heart rate: the HyperGEN Study. Ann Hum Genet. 2006;70:566-73 pubmed
    The association between polymorphisms in the beta1, beta2 and alpha2B adrenergic receptor (ADR) genes (ADRB1, ADRB2 and ADRA2B) and resting heart rate was examined in white and African-American participants of the HyperGEN Study...
  38. Mason D, Moore J, Green S, Liggett S. A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor. J Biol Chem. 1999;274:12670-4 pubmed
    The beta1-adrenergic receptor (beta1AR) is a key cell surface signaling protein expressed in the heart and other organs that mediates the actions of catecholamines of the sympathetic nervous system...
  39. Shioji K, Kokubo Y, Mannami T, Inamoto N, Morisaki H, Mino Y, et al. Association between hypertension and the alpha-adducin, beta1-adrenoreceptor, and G-protein beta3 subunit genes in the Japanese population; the Suita study. Hypertens Res. 2004;27:31-7 pubmed
    ..that have previously been implicated in hypertension: the alpha-adducin (ADD1/Gly460Trp), beta1-adrenoreceptor (ADRB1/Arg389Gly), and G-protein beta3 subunit (GNB3/C825T) gene polymorphisms...
  40. Iwai C, Akita H, Shiga N, Takai E, Miyamoto Y, Shimizu M, et al. Suppressive effect of the Gly389 allele of the beta1-adrenergic receptor gene on the occurrence of ventricular tachycardia in dilated cardiomyopathy. Circ J. 2002;66:723-8 pubmed
    ..29 ([95% confidence interval, 0.13-0.64], p=0.002), when compared with the Arg389 homozygotes. The Gly389 variant supressed the occurrence of VT in DCM, suggesting that this allele confers a decreased risk of sudden death. ..
  41. Li Y, Li N, Yang L, Li Y, Ding X, Zhao H, et al. [Polymorphisms of Arg389Gly of ?1-adrenergic receptor gene and essential hypertension risk: a meta analysis]. Zhonghua Yi Xue Za Zhi. 2011;91:3115-9 pubmed
    ..The Arg389Gly Arg/Arg genotype carriers are associated with an elevated risk of essential hypertension. And Arg389Gly of ?1-adrenergic receptor gene may play a role in the susceptibility of essential hypertension. ..
  42. Covolo L, Gelatti U, Metra M, Nodari S, Piccichè A, Pezzali N, et al. Role of beta1- and beta2-adrenoceptor polymorphisms in heart failure: a case-control study. Eur Heart J. 2004;25:1534-41 pubmed
    ..4; 95%CI 0.5-3.6) and Arg389Gly16 Glu27 (odds ratio = 1.2; 95%CI, 0.5-2.8) homozygous allele combinations. None of the three most common polymorphisms of beta-adrenoreceptors are associated with an increased risk of HF. ..
  43. Terra S, Hamilton K, Pauly D, Lee C, Patterson J, Adams K, et al. Beta1-adrenergic receptor polymorphisms and left ventricular remodeling changes in response to beta-blocker therapy. Pharmacogenet Genomics. 2005;15:227-34 pubmed
    ..Heart failure patients with the Arg389Arg genotype and Gly49 carriers had greater improvements in LV remodeling from beta-blocker treatment. ..
  44. Dionne I, Garant M, Nolan A, Pollin T, Lewis D, Shuldiner A, et al. Association between obesity and a polymorphism in the beta(1)-adrenoceptor gene (Gly389Arg ADRB1) in Caucasian women. Int J Obes Relat Metab Disord. 2002;26:633-9 pubmed
    ..A putative gain-of-function polymorphism in the beta(1)-adrenoceptor was recently discovered (Gly389Arg ADRB1)...
  45. Forleo C, Sorrentino S, Guida P, Romito R, De Tommasi E, Iacoviello M, et al. Beta1- and beta2-adrenergic receptor polymorphisms affect susceptibility to idiopathic dilated cardiomyopathy. J Cardiovasc Med (Hagerstown). 2007;8:589-95 pubmed
  46. Fu C, Wang H, Wang S, Shi Y, Zhou X, Sun K, et al. Association of beta 1-adrenergic receptor gene polymorphisms with left ventricular hypertrophy in human essential hypertension. Clin Biochem. 2008;41:773-8 pubmed publisher
    Experimental evidence support a key role for beta (1)-adrenergic receptor (ADRB1) in the modulation of cardiac mass. This relationship has not yet been described in Chinese population...
  47. Lanfear D, Jones P, Marsh S, Cresci S, McLeod H, Spertus J. Beta2-adrenergic receptor genotype and survival among patients receiving beta-blocker therapy after an acute coronary syndrome. JAMA. 2005;294:1526-33 pubmed
    Previous data support an association between polymorphisms of the beta1- and beta2-adrenergic receptors (ADRB1 and ADRB2) and surrogate end points of response to beta-adrenergic blocker therapy...
  48. Cresci S, Kelly R, Cappola T, Diwan A, Dries D, Kardia S, et al. Clinical and genetic modifiers of long-term survival in heart failure. J Am Coll Cardiol. 2009;54:432-44 pubmed publisher
    ..7%) were treated with a beta-blocker. Each was genotyped for beta1-adrenergic receptor (ADRB1) Arg389>Gly and G-protein receptor kinase 5 (GRK5) Gln41>Leu polymorphisms, which are more prevalent among ..
  49. Sehnert A, Daniels S, Elashoff M, Wingrove J, Burrow C, Horne B, et al. Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol. J Am Coll Cardiol. 2008;52:644-51 pubmed publisher
    ..This study investigated the role of adrenergic receptor genetics on transplant-free survival in heart failure (HF)...
  50. Jin B, Ge Shang Q, Li Y, Shen W, Shi H, Ni H. A meta-analysis of ?1-adrenergic receptor gene polymorphisms in idiopathic dilated cardiomyopathy. Mol Biol Rep. 2012;39:563-7 pubmed publisher
    ..33-15.15; Ph=0.12), but not among Europeans. In summary, this meta-analysis suggests that no statistically increased risk was found between ?1-adrenergic receptor gene polymorphisms and susceptibility to IDCM among Europeans. ..
  51. Matsunaga T, Yasuda K, Adachi T, Gu N, Yamamura T, Moritani T, et al. Association of beta-adrenoceptor polymorphisms with cardiac autonomic modulation in Japanese males. Am Heart J. 2007;154:759-66 pubmed
    ..Several functional genetic variations in the beta-AR genes (ADRB1 or ADRB2) have been identified and implicated as causes of hypertension and cardiovascular disease...
  52. Wagoner L, Craft L, Zengel P, McGuire N, Rathz D, Dorn G, et al. Polymorphisms of the beta1-adrenergic receptor predict exercise capacity in heart failure. Am Heart J. 2002;144:840-6 pubmed
    ..in patients with congestive heart failure is partially dependent on cardiac beta1-adrenergic receptor (beta1AR) function...
  53. Borjesson M, Magnusson Y, Hjalmarson A, Andersson B. A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure. Eur Heart J. 2000;21:1853-8 pubmed
    ..These data suggest that the beta(1)-receptor Ser49Gly variant might be associated with altered receptor function, resulting in myocardial protection in patients with heart failure. ..
  54. McLean R, Hirsch G, Becker L, Kasch Semenza L, Gerstenblith G, Schulman S. Polymorphisms of the beta adrenergic receptor predict left ventricular remodeling following acute myocardial infarction. Cardiovasc Drugs Ther. 2011;25:251-8 pubmed publisher
    ..1, -79) and an increase in LVEF (11%, CI 0.3, 22). We found that polymorphisms of the ?1-AR and ?2-AR genes are associated with differential LV remodeling in patients treated with a ?1 receptor antagonist following STEMI. ..
  55. Peng Y, Xue H, Luo L, Yao W, Li R. Polymorphisms of the beta1-adrenergic receptor gene are associated with essential hypertension in Chinese. Clin Chem Lab Med. 2009;47:1227-31 pubmed publisher
    The beta1-adrenergic receptor (ADRB1) plays a pivotal role in mediating signal transduction of the sympathetic-adrenal system, which is involved in the regulation of cardiac output and peripheral resistance...
  56. Ryden M, Hoffstedt J, Eriksson P, Bringman S, Arner P. The Arg 389 Gly beta1-adrenergic receptor gene polymorphism and human fat cell lipolysis. Int J Obes Relat Metab Disord. 2001;25:1599-603 pubmed
    ..This suggests, despite the altered coupling properties reported in recombinant cells, that the Arg 386 Gly polymorphism has no important influence on human obesity. ..
  57. Yu W, Lou M, Deng B, Song H, Wang H. [Beta1-adrenergic receptor (Arg389Gly) polymorphism and response to bisoprolol in patients with chronic heart failure]. Zhonghua Xin Xue Guan Bing Za Zhi. 2006;34:776-80 pubmed
  58. Lobmeyer M, Gong Y, Terra S, Beitelshees A, Langaee T, Pauly D, et al. Synergistic polymorphisms of beta1 and alpha2C-adrenergic receptors and the influence on left ventricular ejection fraction response to beta-blocker therapy in heart failure. Pharmacogenet Genomics. 2007;17:277-82 pubmed
    The Arg389Gly polymorphism (Arg389Gly) in the beta1-adrenergic receptor gene (ADRB1) has been associated with improvement in left-ventricular remodeling with beta-blocker treatment...
  59. Nicoulina S, Shulman V, Shesternya P, Chernova A, Salmina A, Issachenko O, et al. Association of ADRB1 gene polymorphism with atrial fibrillation. Genet Test Mol Biomarkers. 2010;14:249-53 pubmed publisher
    ..an association of primary and secondary AF with polymorphism Ser49Gly of the gene encoding beta1-adrenoreceptor (ADRB1). We examined 103 probands with AF and 301 relatives...
  60. Parvez B, Chopra N, Rowan S, Vaglio J, Muhammad R, Roden D, et al. A common ?1-adrenergic receptor polymorphism predicts favorable response to rate-control therapy in atrial fibrillation. J Am Coll Cardiol. 2012;59:49-56 pubmed publisher
    ..These findings represent a step forward in the development of a long-term strategy of selecting treatment options in AF based on genotype. ..