Gene Symbol: ADRA1D
Description: adrenoceptor alpha 1D
Alias: ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2, alpha-1D adrenergic receptor, adrenergic, alpha -1D-, receptor, adrenergic, alpha-1A-, receptor, alpha-1A adrenergic receptor, alpha-1D adrenoceptor, alpha-1D adrenoreceptor, alpha-adrenergic receptor 1a
Species: human
Products:     ADRA1D

Top Publications

  1. Esbenshade T, Hirasawa A, Tsujimoto G, Tanaka T, Yano J, Minneman K, et al. Cloning of the human alpha 1d-adrenergic receptor and inducible expression of three human subtypes in SK-N-MC cells. Mol Pharmacol. 1995;47:977-85 pubmed
  2. Kyprianou N, Benning C. Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis. Cancer Res. 2000;60:4550-5 pubmed
    Recent evidence from our laboratory has demonstrated that alpha1-adrenoceptor antagonists doxazosin and terazosin induced apoptosis in prostate epithelial and smooth muscle cells in patients with benign prostatic hypertrophy (BPH; J. Urol...
  3. Keffel S, Alexandrov A, Goepel M, Michel M. alpha(1)-adrenoceptor subtypes differentially couple to growth promotion and inhibition in Chinese hamster ovary cells. Biochem Biophys Res Commun. 2000;272:906-11 pubmed
    ..We conclude that within a given cell type alpha(1)-adrenoceptor subtypes can have opposite effects on cellular growth, although their proximal signal transduction displays only quantitative differences. ..
  4. Zhou Y, Yang Y, Liu Y, Chang H, Liu K, Zhang X, et al. Irp2 Knockout Causes Osteoporosis by Inhibition of Bone Remodeling. Calcif Tissue Int. 2019;104:70-78 pubmed publisher
    ..markers for bone formation such as bone alkaline phosphatase (Balp), bone-gla-protein (BGP), and type I collagen alpha1 chain (Col I α1) were decreased, while markers for bone resorption including cathepsin K (Ctsk) and ..
  5. Picard F, Sayah N, Spagnoli V, Adjedj J, Varenne O. Vasospastic angina: A literature review of current evidence. Arch Cardiovasc Dis. 2019;112:44-55 pubmed publisher
    ..avoidance of vasospastic agents and pharmacotherapy, such as calcium channel blockers, nitrates, statins, aspirin, alpha1-adrenergic receptor antagonists, rho-kinase inhibitors or nicorandil, could be proposed to patients with VSA...
  6. Long Q, Liu X, Qi Q, Guo S. Chronic stress accelerates the development of endometriosis in mouse through adrenergic receptor ?2. Hum Reprod. 2016;31:2506-2519 pubmed
    ..proliferating cell nuclear antigen (PCNA), phosphorylated CREB, ADRB1, ADRB2, ADRB3, adrenergic receptor ?1 (ADRA1) and ADRA2...
  7. Marques A, Nordio L, Lecchi C, Grilli G, Giudice C, Ceciliani F. Widespread extrahepatic expression of acute-phase proteins in healthy chicken (Gallus gallus) tissues. Vet Immunol Immunopathol. 2017;190:10-17 pubmed publisher
    ..the expression of APP in chicken during diseases, this study investigated the presence of five APP, including alpha1-acid glycoprotein (AGP), Serum Amyloid A (SAA), PIT54, C-Reactive protein (CRP) and Ovotransferrin (OVT) in twenty ..
  8. Murai M, Tsuji G, Hashimoto Hachiya A, Kawakami Y, Furue M, Mitoma C. An endogenous tryptophan photo-product, FICZ, is potentially involved in photo-aging by reducing TGF-?-regulated collagen homeostasis. J Dermatol Sci. 2018;89:19-26 pubmed publisher
    ..Myofibroblasts produce a precursor form of type I collagen, type I procollagen (collagen I), consisting of pro-alpha1 (produced by the COL1A1 gene) and pro-alpha2 chains (produced by the COL1A2 gene)...
  9. Juszczak G, Stankiewicz A. Glucocorticoids, genes and brain function. Prog Neuropsychopharmacol Biol Psychiatry. 2018;82:136-168 pubmed publisher
    ..signaling mediated by thyroid hormones (Thra and Sult1a1), calcium (Calm2), adrenaline/noradrenaline (Adcy9 and Adra1d), neuropeptide Y (Npy1r) and histamine (Hdc)...

More Information

Publications144 found, 100 shown here

  1. Tripathi S, Kumar P, Trabulsi E, Kim S, McCue P, Intenzo C, et al. VPAC1 Targeted 64Cu-TP3805 kit preparation and its evaluation. Nucl Med Biol. 2017;51:55-61 pubmed publisher
    ..Specificity of 64Cu-TP3805 for VPAC1 was examined with digital autoradiography (DAR) of prostate tissues obtained after prostatectomy, benign prostatic hyperplasia (BPH) tissue, and benign and ..
  2. Schäff C, Rohrbeck D, Steinhoff Wagner J, Kanitz E, Sauerwein H, Bruckmaier R, et al. Effects of colostrum versus formula feeding on hepatic glucocorticoid and α₁- and β₂-adrenergic receptors in neonatal calves and their effect on glucose and lipid metabolism. J Dairy Sci. 2014;97:6344-57 pubmed publisher
    ..Binding affinities were in the same range for each receptor type. Gene expression of α₁-AR (ADRA1) tended to be lower in CF than FF calves...
  3. Schmitz G, Langmann T. Transcriptional regulatory networks in lipid metabolism control ABCA1 expression. Biochim Biophys Acta. 2005;1735:1-19 pubmed
    ..ours suggests that vesicular transport processes involving different interactive proteins like beta2-syntrophin, alpha1-syntrophin, Lin7, and cdc42 are critically involved in cellular lipid homeostasis controlled by ABCA1 and ABCG1...
  4. Molokanova O, Schonig K, Weng S, Wang X, Bros M, Diken M, et al. Inducible knockdown of procollagen I protects mice from liver fibrosis and leads to dysregulated matrix genes and attenuated inflammation. Matrix Biol. 2018;66:34-49 pubmed publisher
    ..We therefore designed tetracycline-regulated procollagen alpha1(I) short hairpin (sh)RNA expressing mice that permit a highly efficient inducible knockdown of the procollagen ..
  5. Janciauskiene S, Tumpara S, Wiese M, Wrenger S, Vijayan V, Gueler F, et al. Alpha1-antitrypsin binds hemin and prevents oxidative activation of human neutrophils: putative pathophysiological significance. J Leukoc Biol. 2017;102:1127-1141 pubmed publisher
    ..Human alpha1-antitrypsin (A1AT), an acute-phase glycoprotein and important inhibitor of neutrophil proteases, is also a hemin-..
  6. Fumel B, Froment P, Holzenberger M, Livera G, Monget P, Fouchécourt S. Expression of dominant-negative thyroid hormone receptor alpha1 in Leydig and Sertoli cells demonstrates no additional defect compared with expression in Sertoli cells only. PLoS ONE. 2015;10:e0119392 pubmed publisher
    ..This suggests that direct T3 regulation of steroidogenesis through TRα1 is moderate in Leydig cells, and that Sertoli cells are the main target of T3 action in the testis. ..
  7. Gil D, Wang J, Gu C, Donello J, Cabrera S, Al Chaer E. Role of sympathetic nervous system in rat model of chronic visceral pain. Neurogastroenterol Motil. 2016;28:423-31 pubmed publisher
    ..The alpha2-adrenergic agonist, clonidine, and the alpha1-adrenergic antagonist, prazosin, reduced the visceral hypersensitivity and WAS enhanced the pain...
  8. Kilale A, Kimaro G, Kahwa A, Chilagwile M, Ngowi B, Muller W, et al. High prevalence of tuberculosis diagnosed during autopsy examination at Muhimbili National Hospital in Dar es Salaam, Tanzania. Tanzan J Health Res. 2013;15:171-7 pubmed
    ..There is a need for increased awareness and to include post-mortem data in the annual statistics of TB for precise reporting of the magnitude of the TB burden in the country. ..
  9. Sun G, Tarasov A, McGinty J, McDonald A, da Silva Xavier G, Gorman T, et al. Ablation of AMP-activated protein kinase alpha1 and alpha2 from mouse pancreatic beta cells and RIP2.Cre neurons suppresses insulin release in vivo. Diabetologia. 2010;53:924-36 pubmed publisher
    ..However, the precise role or roles of the enzyme in controlling insulin secretion remain uncertain. The catalytic alpha1 and alpha2 subunits of AMPK were ablated selectively in mouse pancreatic beta cells and hypothalamic neurons by ..
  10. Bao X, Borné Y, Johnson L, Muhammad I, Persson M, Niu K, et al. Comparing the inflammatory profiles for incidence of diabetes mellitus and cardiovascular diseases: a prospective study exploring the 'common soil' hypothesis. Cardiovasc Diabetol. 2018;17:87 pubmed publisher
    ..Neutrophil to lymphocyte ratio, ceruloplasmin, alpha1-antitrypsin and soluble urokinase plasminogen activator receptor predicted increased risk of CVD but not DM, while ..
  11. Gonzalez B, Torres O, Jayanthi S, Gomez N, Sosa M, Bernardi A, et al. The effects of single-dose injections of modafinil and methamphetamine on epigenetic and functional markers in the mouse medial prefrontal cortex: potential role of dopamine receptors. Prog Neuropsychopharmacol Biol Psychiatry. 2019;88:222-234 pubmed publisher
    ..on histone 3 acetylation, with modafinil increasing H3ac at Drd1 and Adra1b promoters, but METH increasing H3ac at Adra1a; ii) distinct effects on histone 4 acetylation enrichment, with modafinil increasing H4ac at the Drd2 promoter and ..
  12. Steven S, Hausding M, Kröller Schön S, Mader M, Mikhed Y, Stamm P, et al. Gliptin and GLP-1 analog treatment improves survival and vascular inflammation/dysfunction in animals with lipopolysaccharide-induced endotoxemia. Basic Res Cardiol. 2015;110:6 pubmed publisher
    ..on vascular function and inflammatory parameters in endotoxemic mice were impaired in AMP-activated kinase (alpha1) knockout mice...
  13. Taura K, Miura K, Iwaisako K, Osterreicher C, Kodama Y, Penz Osterreicher M, et al. Hepatocytes do not undergo epithelial-mesenchymal transition in liver fibrosis in mice. Hepatology. 2010;51:1027-36 pubmed publisher
    ..We bred triple transgenic mice expressing ROSA26 stop beta-galactosidase (beta-gal), albumin Cre, and collagen alpha1(I) green fluorescent protein (GFP), in which hepatocyte-derived cells are permanently labeled by beta-gal and type ..
  14. Shah M, Kola B, Bataveljic A, Arnett T, Viollet B, Saxon L, et al. AMP-activated protein kinase (AMPK) activation regulates in vitro bone formation and bone mass. Bone. 2010;47:309-19 pubmed publisher
    ..Both cortical and trabecular bone compartments were smaller in the AMPK alpha1-deficient mice compared to the WT mice...
  15. Yu M, Pisitkun T, Wang G, Shen R, Knepper M. LC-MS/MS analysis of apical and basolateral plasma membranes of rat renal collecting duct cells. Mol Cell Proteomics. 2006;5:2131-45 pubmed
    ..Immunofluorescence confocal microscopy confirmed ACVRL1, H(+)/K(+)-ATPase alpha1, NHE2, and TauT expression in the IMCDs...
  16. Brown S, Meuth A, Davis J, Rector R, Bender S. Mineralocorticoid receptor antagonism reverses diabetes-related coronary vasodilator dysfunction: A unique vascular transcriptomic signature. Pharmacol Res. 2018;134:100-108 pubmed publisher
    ..oxide bioavailability (Hsp90ab1, Ahsa1, Ahsa2) as well as novel changes in α1D adrenergic receptors (Adra1d), cyclooxygenase-2 (Ptgs2), and modulatory factors of these pathways (Ackr3, Acsl4)...
  17. Petter da Silva F, Beatriz Dallepiane L, Ramos Kirsten V, Maria Kirchner R. [Not Available]. Nutr Hosp. 2016;33:37-42 pubmed publisher
    ..Una ingesta inadecuada de nutrientes puede dar lugar a deficiencias nutricionales y, por lo tanto, a cambios fisiológicos y patológicos que pondrían en peligro ..
  18. Huan H, Wen X, Chen X, Wu L, Wu L, Zhang L, et al. Sympathetic nervous system promotes hepatocarcinogenesis by modulating inflammation through activation of alpha1-adrenergic receptors of Kupffer cells. Brain Behav Immun. 2017;59:118-134 pubmed publisher
    ..These results indicate that sympathetic denervation or ?1-ARs blockage may represent novel treatment approaches for HCC. ..
  19. Nuutinen S, Ailanen L, Savontaus E, Rinne P. Melanocortin overexpression limits diet-induced inflammation and atherosclerosis in LDLR-/- mice. J Endocrinol. 2018;236:111-123 pubmed publisher
    ..These results show that the activation of the melanocortin system improves glucose homeostasis and limits diet-induced vascular inflammation and atherosclerotic plaque formation. ..
  20. Nombo A, Mwanri A, Brouwer Brolsma E, Ramaiya K, Feskens E. Gestational diabetes mellitus risk score: A practical tool to predict gestational diabetes mellitus risk in Tanzania. Diabetes Res Clin Pract. 2018;145:130-137 pubmed publisher
    ..We used cross-sectional data of 609 pregnant women, without known diabetes, collected in six health facilities from Dar es Salaam city (urban). Women underwent screening for GDM during ante-natal clinics visit...
  21. Ruíz González V, Cancino Diaz J, Rodríguez Martínez S, Cancino Diaz M. Keratinocytes treated with peptidoglycan from Staphylococcus aureus produce vascular endothelial growth factor, and its expression is amplified by the subsequent production of interleukin-13. Int J Dermatol. 2009;48:846-54 pubmed publisher regulated by human cathelicidin LL37, and the expression of this peptide, as well as interleukin-13 receptor-alpha1 (IL-13Ralpha1) and VEGF, is increased in psoriatic skin...
  22. Sudfeld C, Mugusi F, Aboud S, Nagu T, Wang M, Fawzi W. Efficacy of vitamin D3 supplementation in reducing incidence of pulmonary tuberculosis and mortality among HIV-infected Tanzanian adults initiating antiretroviral therapy: study protocol for a randomized controlled trial. Trials. 2017;18:66 pubmed publisher
    ..HIV-infected adults with low vitamin D levels [25-hydroxyvitamin D (25(OH)D) <30 ng/mL] initiating ART in Dar es Salaam, Tanzania...
  23. Ferreira Silva R, Rita Carvalho Garbi Novaes M. Interactions between drugs and drug-nutrient in enteral nutrition: a review based on evidences. Nutr Hosp. 2014;30:514-8 pubmed publisher
    ..interacciones como la del hidróxido de aluminio y lactulosa con la nutrición enteral, lo que podría dar lugar a una precipitación y reducción de la biodisponibilidad del fármaco...
  24. Pinheiro Volp A, Santos Silva F, Bressan J. Hepatic inflammatory biomarkers and its link with obesity and chronic diseases. Nutr Hosp. 2015;31:1947-56 pubmed publisher
    ..Some of those biomarkers are sialic acid, α1-antitrypsin and the C-terminal fragment of alpha1-antitrypsin, ceruloplasmin, fibrinogen, haptoglobin, homocystein and plasminogen activator inhibitor-1...
  25. Kaczmarek I, Prost M, Wasyluk J. Clinical risk factors associated with intraoperative floppy iris syndrome: a prospective study. Int Ophthalmol. 2019;39:541-549 pubmed publisher
    ..of pseudoexfoliation syndrome, glaucoma, diabetes mellitus, hypertension, current use of medications including alpha1 adrenergic receptor antagonists (alpha1-ARAs), finasteride, and benzodiazepines, duration of intake of alpha1-ARAs ..
  26. Mohamed Z, Mbwambo J, Shimakawa Y, Poiteau L, Chevaliez S, Pawlotsky J, et al. Clinical utility of HCV core antigen detection and quantification using serum samples and dried blood spots in people who inject drugs in Dar-es-Salaam, Tanzania. J Int AIDS Soc. 2017;20:21856 pubmed publisher
    ..Although HCVcAg detection and quantification in DBS has a reduced sensitivity, its specificity and accuracy are good and it could therefore be used for scaling up HCV testing and care in resource-limited African settings. ..
  27. Abioye A, Aboud S, Premji Z, Etheredge A, Gunaratna N, Sudfeld C, et al. Iron Supplementation Affects Hematologic Biomarker Concentrations and Pregnancy Outcomes among Iron-Deficient Tanzanian Women. J Nutr. 2016;146:1162-71 pubmed publisher
    ..600 iron-deficient (serum ferritin ?12 ?g/L) pregnant women, aged 18-45 y, presenting to 2 antenatal clinics in Dar es Salaam, Tanzania using rapid ferritin screening tests, and prospectively followed them through delivery and ..
  28. Ebstie Y, Zeynudin A, Belachew T, Desalegn Z, Suleman S. Assessment of therapeutic efficacy and safety of artemether-lumefantrine (Coartem®) in the treatment of uncomplicated Plasmodium falciparum malaria patients in Bahir Dar district, Northwest Ethiopia: an observational cohort study. Malar J. 2015;14:236 pubmed publisher
    ..artemether-lumefantrine has been used as first-line drug for uncomplicated Plasmodium falciparum malaria in Bahir Dar district since 2004, its efficacy has not yet been assessed...
  29. Burke P, Hamilton J, Jeffrey S, Hunter J, Doronina S, Okeley N, et al. Optimization of a PEGylated Glucuronide-Monomethylauristatin E Linker for Antibody-Drug Conjugates. Mol Cancer Ther. 2017;16:116-123 pubmed publisher
    ..plasma clearance and suboptimal in vivo activity, particularly for conjugates with high drug-to-antibody ratios (DAR)...
  30. Juliant S, Harduin Lepers A, Monjaret F, Catieau B, Violet M, Cérutti P, et al. The α1,6-fucosyltransferase gene (fut8) from the Sf9 lepidopteran insect cell line: insights into fut8 evolution. PLoS ONE. 2014;9:e110422 pubmed publisher
    The core alpha1,6-fucosyltransferase (FUT8) catalyzes the transfer of a fucosyl moiety from GDP-fucose to the innermost asparagine-linked N-acetylglucosamine residue of glycoproteins...
  31. Stojkov Mimic N, Bjelic M, Radovic S, Mihajlovic A, Sokanovic S, Baburski A, et al. Intratesticular alpha1-adrenergic receptors mediate stress-disturbed transcription of steroidogenic stimulator NUR77 as well as steroidogenic repressors DAX1 and ARR19 in Leydig cells of adult rats. Mol Cell Endocrinol. 2015;412:309-19 pubmed publisher
    ..Adrenaline-induced increase of repressor Dax1 also involves ADRs in Leydig cells. Accordingly, α1-ADRs participate in some of the stress-triggered effects on the steroidogenic machinery of Leydig cells. ..
  32. Svärd J, Mugusi S, Mloka D, Neogi U, Meini G, Mugusi F, et al. Drug resistance testing through remote genotyping and predicted treatment options in human immunodeficiency virus type 1 infected Tanzanian subjects failing first or second line antiretroviral therapy. PLoS ONE. 2017;12:e0178942 pubmed publisher
    ..defined by clinical or immunological criteria, as well as from a control group of ART naïve subjects (n = 17) in Dar es Salaam, Tanzania...
  33. Cai L, Fritz D, Stefanovic L, Stefanovic B. Nonmuscle myosin-dependent synthesis of type I collagen. J Mol Biol. 2010;401:564-78 pubmed publisher
    Type I collagen, synthesized in all tissues as the heterotrimer of two alpha1(I) polypeptides and one alpha2(I) polypeptide, is the most abundant protein in the human body...
  34. Kileo N, Michael D, Neke N, Moshiro C. Utilization of cervical cancer screening services and its associated factors among primary school teachers in Ilala Municipality, Dar es Salaam, Tanzania. BMC Health Serv Res. 2015;15:552 pubmed publisher
    ..cancer screening services, and its associated factors among female primary school teachers in Ilala Municipality, Dar es Salaam...
  35. Velligan D, Mintz J, Sierra C, Martin M, Fredrick M, Maglinte G, et al. The Daily Activity Report (DAR) a Novel Measure of Functional Outcome for Serious Mental Illness. Schizophr Bull. 2016;42:579-87 pubmed publisher
    ..We tested the psychometric properties of the Daily Activity Report (DAR), a novel assessment of productive daily activity...
  36. Chien C, Wu H. Young rats exhibit an age- and sex-dependent bladder response to alpha-antagonists but not beta-agonists. J Pediatr Urol. 2016;12:92.e1-8 pubmed publisher
    ..The use of alpha1- (α1-) antagonists for dysfunctional voiding, and beta3- (β3-) agonists for overactive bladder in younger ..
  37. Geldsetzer P, Francis J, ULENGA N, Sando D, Lema I, Mboggo E, et al. The impact of community health worker-led home delivery of antiretroviral therapy on virological suppression: a non-inferiority cluster-randomized health systems trial in Dar es Salaam, Tanzania. BMC Health Serv Res. 2017;17:160 pubmed publisher
    ..This is a non-inferiority cluster-randomized trial set in Dar es Salaam, Tanzania. A cluster is one of 48 healthcare facilities with its surrounding catchment area...
  38. Fattorini L, Veloccia A, Della Rovere F, D Angeli S, Falasca G, Altamura M. Indole-3-butyric acid promotes adventitious rooting in Arabidopsis thaliana thin cell layers by conversion into indole-3-acetic acid and stimulation of anthranilate synthase activity. BMC Plant Biol. 2017;17:121 pubmed publisher
    ..PIN1) and IAA-influx (AUX1/LAX3) genes, IAA-influx carriers activities, and expression of ANTHRANILATE SYNTHASE -alpha1 (ASA1), a gene involved in IAA-biosynthesis...
  39. Miller C, Huston J, Samu L, Mfinanga S, Hopewell P, Fair E. 'It makes the patient's spirit weaker': tuberculosis stigma and gender interaction in Dar es Salaam, Tanzania. Int J Tuberc Lung Dis. 2017;21:42-48 pubmed publisher
    b>Dar es Salaam, Tanzania.
  40. Mselle L, Kohi T. Healthcare access and quality of birth care: narratives of women living with obstetric fistula in rural Tanzania. Reprod Health. 2016;13:87 pubmed publisher
    ..Semi-structured interviews were carried out at CCBRT hospital in Dar es Salaam...
  41. Pickering J, Cunliffe V, van Eeden F, Borycki A. Hedgehog signalling acts upstream of Laminin alpha1 transcription in the zebrafish paraxial mesoderm. Matrix Biol. 2017;62:58-74 pubmed publisher
  42. Walle A, Woldie M. Client-Centeredness of Family Planning Services in a Resource Limited Setting. Ethiop J Health Sci. 2017;27:373-382 pubmed
    ..This study assessed the level of client-centeredness of family planning services and their determinants in public health facilities of Bahir Dar Town, Northwest Ethiopia.
  43. Guillén López S, Ibarra González I, Belmont Martínez L, Juárez Cruz M, Vela Amieva M. [COMPARISON OF FREE CARNITINE LEVELS WITH NUTRITIONAL STATUS IN INFANTILE NEPHROPATHYC CISTINOSIS PATIENTS]. Nutr Hosp. 2015;32:2613-7 pubmed publisher
    ..con esta patología, pero se sabe que tienen una excreción de carnitina urinaria aumentada, lo que puede dar como resultado una deficiencia plasmática y muscular de este compuesto; sin embargo, la suplementación de ..
  44. Doki T, Takano T, Kawagoe K, Kito A, Hohdatsu T. Therapeutic effect of anti-feline TNF-alpha monoclonal antibody for feline infectious peritonitis. Res Vet Sci. 2016;104:17-23 pubmed publisher
    ..Plasma alpha1-glycoprotein and vascular endothelial growth factor levels were improved by the administration of mAb 2-4, and the ..
  45. Bella M, Borgiattino V. [Demand for hospitalization due to psychosocial causes in a pediatric hospital]. Arch Argent Pediatr. 2016;114:252-7 pubmed publisher
    ..y aumento de consultas por causas mentales y violencia, y no cuentan con la capacidad suficiente para dar respuesta a esta demanda...
  46. Wolderslund M, Kofoed P, Holst R, Axboe M, Ammentorp J. Digital audio recordings improve the outcomes of patient consultations: A randomised cluster trial. Patient Educ Couns. 2017;100:242-249 pubmed publisher
    To investigate the effects on patients' outcome of the consultations when provided with: a Digital Audio Recording (DAR) of the consultation and a Question Prompt List (QPL). This is a three-armed randomised controlled cluster trial...
  47. Kachwamba Y, Mohammed A, Lukupulo H, Urio L, Majigo M, Mosha F, et al. Genetic Characterization of Vibrio cholerae O1 isolates from outbreaks between 2011 and 2015 in Tanzania. BMC Infect Dis. 2017;17:157 pubmed publisher
    ..Remarkably, one MLVA CC contained isolates from both the May outbreak and ones from the 2011/2012 outbreak in Dar-es-Salaam. However, WGS revealed the isolates from the two outbreaks to be distinct clades...
  48. Zhumagaliyeva A, Ottaviani S, Greulich T, Gorrini M, Vogelmeier C, Karazhanova L, et al. Case-finding for alpha1-antitrypsin deficiency in Kazakh patients with COPD. Multidiscip Respir Med. 2017;12:23 pubmed publisher
    ..Alpha-1-antitrypsin deficiency (AATD) is an under-diagnosed condition in patients with chronic obstructive pulmonary disease (COPD). The aim of this study was to screen for AATD in Kazakh patients with COPD using dried blood spot specimens...
  49. Gonzalez Cabrera P, Shi T, Yun J, McCune D, Rorabaugh B, Perez D. Differential regulation of the cell cycle by alpha1-adrenergic receptor subtypes. Endocrinology. 2004;145:5157-67 pubmed
  50. Albrecht D, Sherman D, Brophy P, Froehner S. The ABCA1 cholesterol transporter associates with one of two distinct dystrophin-based scaffolds in Schwann cells. Glia. 2008;56:611-8 pubmed publisher
    ..the Schwann cell dystrophin glycoprotein complex (DGC) by establishing the presence of four syntrophin isoforms, (alpha1, beta1, beta2, and gamma2), and one dystrobrevin isoform, (alpha-dystrobrevin-1), in the abaxonal membrane...
  51. Mulawa M, Yamanis T, Hill L, Balvanz P, Kajula L, Maman S. Evidence of social network influence on multiple HIV risk behaviors and normative beliefs among young Tanzanian men. Soc Sci Med. 2016;153:35-43 pubmed publisher
    ..a unique dataset of mostly young men (n = 1249 men and 242 women) nested within 59 urban social networks in Dar es Salaam, Tanzania...
  52. Wang X, Lenke L, Thuet E, Blanke K, Koester L, Roth M. Deformity Angular Ratio Describes the Severity of Spinal Deformity and Predicts the Risk of Neurologic Deficit in Posterior Vertebral Column Resection Surgery. Spine (Phila Pa 1976). 2016;41:1447-55 pubmed publisher
    Retrospective review of prospectively collected data. To assess the value of the deformity angular ratio (DAR, maximum Cobb measurement divided by number of vertebrae involved) in evaluating the severity of spinal deformity, and ..
  53. Sweet L, Pereira C, Ford R, Feeley A, Badham J, Mengkheang K, et al. Assessment of corporate compliance with guidance and regulations on labels of commercially produced complementary foods sold in Cambodia, Nepal, Senegal and Tanzania. Matern Child Nutr. 2016;12 Suppl 2:106-25 pubmed publisher
    ..sold in Phnom Penh (n?=?70), Cambodia; Kathmandu Valley (n?=?22), Nepal; Dakar Department (n?=?84), Senegal; and Dar es Salaam (n?=?26), Tanzania. Between 3.6% and 30% of products did not provide any age recommendation and 8.6-20...
  54. Nada A, El Noury A, Al Inany H, Bibars M, Taha T, Salama S, et al. Effect of laser-assisted zona thinning, during assisted reproduction, on pregnancy outcome in women with endometriosis: randomized controlled trial. Arch Gynecol Obstet. 2018;297:521-528 pubmed publisher
    ..Pan African Clinical Trials Registry (PACTR), , PACTR201602001467322.
  55. Ahman A, Edvardsson K, Lesio Kidanto H, Ngarina M, Small R, Mogren I. 'Without ultrasound you can't reach the best decision' - Midwives' experiences and views of the role of ultrasound in maternity care in Dar Es Salaam, Tanzania. Sex Reprod Healthc. 2018;15:28-34 pubmed publisher
    ..2015, five focus group discussions were conducted with midwives (N?=?31) at three public referral hospitals in the Dar es Salaam region as part of the CROss Country Ultrasound Study (CROCUS)...
  56. Peters M, Adams M, Froehner S. Differential association of syntrophin pairs with the dystrophin complex. J Cell Biol. 1997;138:81-93 pubmed
    The syntrophins are a multigene family of intracellular dystrophin-associated proteins comprising three isoforms, alpha1, beta1, and beta2...
  57. Dirksen A, Holstein Rathlou N, Madsen F, Skovgaard L, Ulrik C, Heckscher T, et al. Long-range correlations of serial FEV1 measurements in emphysematous patients and normal subjects. J Appl Physiol (1985). 1998;85:259-65 pubmed
    ..Nineteen patients with severe alpha1-antitrypsin deficiency (phenotype PiZ) and moderate to severe emphysema and two subjects with normal lungs were ..
  58. Whitley P, Gibbard A, Koumanov F, Oldfield S, Kilgour E, Prestwich G, et al. Identification of centaurin-alpha2: a phosphatidylinositide-binding protein present in fat, heart and skeletal muscle. Eur J Cell Biol. 2002;81:222-30 pubmed
    ..5 kDa. Centaurin-alpha2 shares 51-59% identity with centaurin-alpha1 proteins and has the same domain organisation, consisting of a predicted N-terminal ArfGAP domain followed by two ..
  59. Sabelis A, Kuijpers M, Nada R, Chiu Y, Bronkhorst E, Kuijpers Jagtman A, et al. Rating dental arch relationships and palatal morphology with the EUROCRAN index on three different formats of dental casts in children with unilateral cleft lip and palate. Clin Oral Investig. 2016;20:943-50 pubmed publisher
    The EUROCRAN index has been used in inter-center studies to assess dental arch relationship (DAR) and palatal morphology (PM) in children with unilateral cleft lip and palate (UCLP)...
  60. Walle B, Lebeta K, Fita Y, Abdissa H. Prevalence of erectile dysfunction and associated factors among diabetic men attending the diabetic clinic at Felege Hiwot Referral Hospital, Bahir Dar, North West Ethiopia, 2016. BMC Res Notes. 2018;11:130 pubmed publisher
    ..97, 95% CI 1.06-17.36). Therefore, screening for ED in diabetic patients, particularly for those who are in advanced age and living with DM for more than 10 years is needed for it's early detection, prevention and management. ..
  61. Dostanic Larson I, Van Huysse J, Lorenz J, Lingrel J. The highly conserved cardiac glycoside binding site of Na,K-ATPase plays a role in blood pressure regulation. Proc Natl Acad Sci U S A. 2005;102:15845-50 pubmed
    ..Because the alpha1 isoform is sensitive to cardiac glycosides in humans, we developed mice in which the naturally occurring ouabain-..
  62. Cotecchia S, Del Vescovo C, Colella M, Caso S, Diviani D. The alpha1-adrenergic receptors in cardiac hypertrophy: signaling mechanisms and functional implications. Cell Signal. 2015;27:1984-93 pubmed publisher
    ..This review will summarize the main signaling pathways activated by the α1-AR in the heart and their functional implications in cardiac hypertrophy. ..
  63. Olofin I, Liu E, Manji K, Danaei G, Duggan C, Aboud S, et al. Active Tuberculosis in HIV-Exposed Tanzanian Children up to 2 years of Age: Early-Life Nutrition, Multivitamin Supplementation and Other Potential Risk Factors. J Trop Pediatr. 2016;62:29-37 pubmed publisher
    ..Participants were children from a randomized controlled multivitamin supplementation trial conducted in Dar es Salaam, Tanzania, from August 2004 to May 2008, who received daily multivitamin supplements or placebo for 24 ..
  64. Nelson S, Kim J, Wilson F, Soliman A, Ngoma T, Kahesa C, et al. Cost-Effectiveness of Screening and Treatment for Cervical Cancer in Tanzania: Implications for other Sub-Saharan African Countries. Value Health Reg Issues. 2016;10:1-6 pubmed publisher
    ..screened and those not screened before treatment for cervical cancer at Ocean Road Cancer Institute (ORCI) in Dar es Salaam, Tanzania-and to perform a cost-effectiveness analysis of the ORCI cervical cancer screening program...
  65. Goyal D, Goyal R. Developmental Maturation and Alpha-1 Adrenergic Receptors-Mediated Gene Expression Changes in Ovine Middle Cerebral Arteries. Sci Rep. 2018;8:1772 pubmed publisher
    ..regulators of cerebrovascular tone and cerebral blood flow (CBF), mediating its effects in the arteries through alpha1-adrenergic receptors (Alpha1AR)...
  66. Schwinn D, Johnston G, Page S, Mosley M, Wilson K, Worman N, et al. Cloning and pharmacological characterization of human alpha-1 adrenergic receptors: sequence corrections and direct comparison with other species homologues. J Pharmacol Exp Ther. 1995;272:134-42 pubmed
    ..published data, at both nucleotide and amino acid levels; the most major differences occur for the human alpha-1a/dAR. Pharmacological characterization was performed simultaneously using six cloned alpha-1AR subtypes (human and rat ..
  67. Songu Mize E, Sevieux N, Liu X, Jacobs M. Effect of short-term cyclic stretch on sodium pump activity in aortic smooth muscle cells. Am J Physiol Heart Circ Physiol. 2001;281:H2072-8 pubmed
    We previously demonstrated that expression of both the alpha1- and alpha2-subunits of Na+-K+-ATPase is elevated after a 2- to 4-day cyclic stretch in aortic smooth muscle cells...
  68. Ferrarotti I, Poplawska Wisniewska B, Trevisan M, Koepke J, Dresel M, Koczulla R, et al. How Can We Improve the Detection of Alpha1-Antitrypsin Deficiency?. PLoS ONE. 2015;10:e0135316 pubmed publisher
    The Z deficiency in α1-antitrypsin (A1ATD) is an under-recognized condition. Alpha1-antitrypsin (A1AT) is the main protein in the α1-globulin fraction of serum protein electrophoresis (SPE); however, evaluation of the α1-globulin ..
  69. Utianski R, Caviness J, van Straaten E, Beach T, Dugger B, Shill H, et al. Graph theory network function in Parkinson's disease assessed with electroencephalography. Clin Neurophysiol. 2016;127:2228-36 pubmed publisher
    ..between control and PD-CN; in contrast, decreased local integration occurred in PD-D when compared to PD-CN in the alpha1 frequency band. Differences found in PD-MCI mirrored PD-D...
  70. Hill L, Gottfredson N, Kajula L, PENCE B, Go V, Moody J, et al. Changes in Anxiety and Depression Symptoms Predict Sexual Risk Behaviors Among Young Men Living in Dar es Salaam, Tanzania. AIDS Behav. 2018;22:1435-1445 pubmed publisher
    ..controlling for baseline sexual risk behaviors among 1113 male members of social groups known as "camps" in Dar es Salaam, Tanzania...
  71. Corda L, Vizzardi E, De Cicco G, D Aloia A, Farina D, Morone M, et al. Left ventricular pseudoaneurysm and α1-antitrypsin enzyme deficiency: another pathological correlation. Int J Cardiol. 2010;145:384-386 pubmed publisher
    b>Alpha1-antitrypsin deficiency (A1ATD) is usually linked to chronic lung dysfunction and chronic liver disease. Recent evidence have shown involvement also of the cardiovascular system...
  72. Tripathi S, Trabulsi E, Gomella L, Kim S, McCue P, Intenzo C, et al. VPAC1 Targeted (64)Cu-TP3805 Positron Emission Tomography Imaging of Prostate Cancer: Preliminary Evaluation in Man. Urology. 2016;88:111-8 pubmed publisher
    ..3 benign prostatic hyperplasia patients, 1 malignant and 1 benign lymph node underwent digital autoradiography (DAR) after (64)Cu-TP3805 incubation and were compared to hematoxylin- and eosin-stained slides...
  73. Ambikile J, Iseselo M. Mental health care and delivery system at Temeke hospital in Dar es Salaam, Tanzania. BMC Psychiatry. 2017;17:109 pubmed publisher
    ..A qualitative study was conducted at Temeke hospital in Dar es Salaam, involving 7 in-depth interviews with mental health care providers, 7 in-depth interviews with mentally ..
  74. Ling L, Chen H, Liu C, Chen S, Jin Y, Zhou J. Capillarys 2 Flex Piercing Detected a Rare Case of Hb Broomhill. Ann Clin Lab Sci. 2017;47:625-627 pubmed
    ..6%). Eventually, sequencing analysis of ? genes confirmed a missense mutation (CCC>GCC at codon 114 in alpha1 gene) which caused Hb Broomhill variant...
  75. Munehira Y, Ohnishi T, Kawamoto S, Furuya A, Shitara K, Imamura M, et al. Alpha1-syntrophin modulates turnover of ABCA1. J Biol Chem. 2004;279:15091-5 pubmed
    ..Two PDZ (PSD95-Discs large-ZO1) proteins, alpha1-syntrophin and Lin7, were found to interact with ABCA1...
  76. Liu Z, Zhou Z, Wang L, Dong W, Qiu L, Song L. The cholinergic immune regulation mediated by a novel muscarinic acetylcholine receptor through TNF pathway in oyster Crassostrea gigas. Dev Comp Immunol. 2016;65:139-148 pubmed publisher
    ..05). Such trend could be reverted with the addition of M3 and M5 muscarinic receptor antagonists DAMP and DAR. The CgmAChR-1 transcripts were ubiquitously detectable in seven different tissues with the maximal expression ..
  77. Mioto P, Rodriguez Ruiz M, Mot A, Zuccarelli R, Corpas F, Freschi L, et al. Alternative fluorimetric-based method to detect and compare total S-nitrosothiols in plants. Nitric Oxide. 2017;68:7-13 pubmed publisher UV light, cleaving the bond and allowing the quantification of the derived NO molecules by diamino-rhodamine (DAR) dyes...
  78. Almanza Sepúlveda M, Hernández González M, Hevia Orozco J, Amezcua Gutiérrez C, Guevara M. Verbal and visuospatial working memory during pregnancy: EEG correlation between the prefrontal and parietal cortices. Neurobiol Learn Mem. 2018;148:1-7 pubmed publisher
    ..During the visuospatial WM task, the T1 and T3 groups showed a higher left EEG correlation in the delta and alpha1 bands, whereas T2 presented a higher right prefrontal-parietal correlation in the gamma band...
  79. Weinberg D, Trivedi P, Tan C, Mitra S, Perkins Barrow A, Borkowski D, et al. Cloning, expression and characterization of human alpha adrenergic receptors alpha 1a, alpha 1b and alpha 1c. Biochem Biophys Res Commun. 1994;201:1296-304 pubmed
    ..The availability of the three human alpha 1 receptor subtypes will facilitate the development of subtype-selective alpha 1 antagonists for a variety of therapeutic indications. ..
  80. Davis J, Kagan M, Read J, Walles M, Hatsis P. Immunoprecipitation middle-up LC-MS for in vivo drug-to-antibody ratio determination for antibody-drug conjugates. Bioanalysis. 2017;9:1535-1549 pubmed publisher
    Drug-to-antibody ratio (DAR) determination is critical for development of antibody-drug conjugates (ADCs). This work presents a middle-up LC-MS approach for DAR analysis using prelabeled capture beads and in-house fabricated slit-plates...
  81. Chen Z, Hague C, Hall R, Minneman K. Syntrophins regulate alpha1D-adrenergic receptors through a PDZ domain-mediated interaction. J Biol Chem. 2006;281:12414-20 pubmed
    ..This direct interaction may provide new information about the regulation of alpha1D-AR signaling and the role of syntrophins in modulating G protein-coupled receptor function. ..
  82. Tewabe T, Mohammed S, Tilahun Y, Melaku B, Fenta M, Dagnaw T, et al. Clinical outcome and risk factors of neonatal sepsis among neonates in Felege Hiwot referral Hospital, Bahir Dar, Amhara Regional State, North West Ethiopia 2016: a retrospective chart review. BMC Res Notes. 2017;10:265 pubmed publisher was to assess clinical outcome and risk factors of neonatal sepsis in Felege Hiwot referral hospital Bahir Dar, North West Ethiopia. Among the total 225 neonatal charts reviewed; 164 (72...
  83. Hasan M, Shang Y, Akhter G, Jin W. Geophysical Assessment of Groundwater Potential: A Case Study from Mian Channu Area, Pakistan. Ground Water. 2017;: pubmed publisher
    ..The aquifer parameters, namely, transmissivity and hydraulic conductivity were estimated from Dar Zarrouyk parameters by interpreting the layer parameters such as true resistivities and thicknesses...
  84. Esquinas C, Janciauskiene S, Gonzalo R, Mas de Xaxars G, Olejnicka B, Belmonte I, et al. Gene and miRNA expression profiles in PBMCs from patients with severe and mild emphysema and PiZZ alpha1-antitrypsin deficiency. Int J Chron Obstruct Pulmon Dis. 2017;12:3381-3390 pubmed publisher
    ..Among genetic determinants, the most recognized is a severe PiZZ (Glu342Lys) inherited alpha1-antitrypsin deficiency (AATD)...
  85. Kimura T, Hashimoto I, Nagase T, Fujisawa J. CRM1-dependent, but not ARE-mediated, nuclear export of IFN-alpha1 mRNA. J Cell Sci. 2004;117:2259-70 pubmed
    ..potential CRM1 pathways for other cellular mRNAs under stress conditions, the nuclear export of human interferon-alpha1 (IFN-alpha1) mRNA, an ERG mRNA induced upon viral infection, was studied...
  86. Nonen S, Okamoto H, Fujio Y, Takemoto Y, Yoshiyama M, Hamaguchi T, et al. Polymorphisms of norepinephrine transporter and adrenergic receptor alpha1D are associated with the response to beta-blockers in dilated cardiomyopathy. Pharmacogenomics J. 2008;8:78-84 pubmed
    ..The polymorphisms of NET T-182C (P=0.019), ADRA1D T1848A (P=0.023) and ADRA1D A1905G (P=0...
  87. Ahmad S, Khan M, Parvez S, Akhtar M, Raisuddin S. Molecular docking reveals the potential of phthalate esters to inhibit the enzymes of the glucocorticoid biosynthesis pathway. J Appl Toxicol. 2017;37:265-277 pubmed publisher
    ..These interactions mainly included H-bonding, hydrophobic, polar and van dar Waals' interactions...
  88. Zhang C, Bi C, Clarke W, Hage D. Glycoform analysis of alpha1-acid glycoprotein based on capillary electrophoresis and electrophoretic injection. J Chromatogr A. 2017;1523:114-122 pubmed publisher
    ..A similar approach may be useful in examining additional glycoproteins in serum or other types of biological samples. ..
  89. Derso T, Tariku A, Ambaw F, Alemenhew M, Biks G, Nega A. Socio-demographic factors and availability of piped fountains affect food hygiene practice of food handlers in Bahir Dar Town, northwest Ethiopia: a cross-sectional study. BMC Res Notes. 2017;10:628 pubmed publisher
    ..the study aimed to assess food handling practice and associated factors among food handlers of Restaurants in Bahir Dar Town, northwest, Ethiopia...
  90. Chen Z, McConell G, Michell B, Snow R, Canny B, Kemp B. AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation. Am J Physiol Endocrinol Metab. 2000;279:E1202-6 pubmed
    ..Here, we show that a 30-s bicycle sprint exercise increases the activity of the human skeletal muscle AMPK-alpha1 and -alpha2 isoforms approximately two- to threefold and the phosphorylation of ACC at Ser(79) (AMPK ..
  91. Suzuki N, Hajicek N, Kozasa T. Regulation and physiological functions of G12/13-mediated signaling pathways. Neurosignals. 2009;17:55-70 pubmed publisher
    ..In this review, we will focus on the mechanisms regulating the Galpha12/13 signaling system, particularly the Galpha12/13-RH-RhoGEF-Rho pathway, which can regulate a wide variety of cellular functions from migration to transformation. ..
  92. Maman S, Kajula L, Balvanz P, Kilonzo M, Mulawa M, Yamanis T. Leveraging strong social ties among young men in Dar es Salaam: A pilot intervention of microfinance and peer leadership for HIV and gender-based violence prevention. Glob Public Health. 2016;11:1202-1215 pubmed
    ..We piloted a microfinance and health promotion intervention among social networks of primarily young men in Dar es Salaam...