ADIPOR2

Summary

Gene Symbol: ADIPOR2
Description: adiponectin receptor 2
Alias: ACDCR2, PAQR2, adiponectin receptor protein 2, progestin and adipoQ receptor family member 2, progestin and adipoQ receptor family member II
Species: human
Products:     ADIPOR2

Top Publications

  1. Halvatsiotis I, Tsiotra P, Ikonomidis I, Kollias A, Mitrou P, Maratou E, et al. Genetic variation in the adiponectin receptor 2 (ADIPOR2) gene is associated with coronary artery disease and increased ADIPOR2 expression in peripheral monocytes. Cardiovasc Diabetol. 2010;9:10 pubmed publisher
    ..date two adiponectin receptors have been discovered, adiponectin receptor 1 (ADIPOR1) and adiponectin receptor 2 (ADIPOR2)...
  2. Kotronen A, Yki Jarvinen H, Aminoff A, Bergholm R, Pietiläinen K, Westerbacka J, et al. Genetic variation in the ADIPOR2 gene is associated with liver fat content and its surrogate markers in three independent cohorts. Eur J Endocrinol. 2009;160:593-602 pubmed publisher
    ..SNPs) in acyl-CoA synthetase long-chain family member 4 (ACSL4), adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2), and the three peroxisome proliferator-activated receptors (PPARA, PPARD, and PPARG) were analyzed...
  3. Pang T, Narendran P. The distribution of adiponectin receptors on human peripheral blood mononuclear cells. Ann N Y Acad Sci. 2008;1150:143-5 pubmed publisher
    ..Its actions are mediated by two receptors, adiponectin receptors 1 (ADIPOR1) and 2 (ADIPOR2). In this study, we measured their distribution on human peripheral mononuclear cells by flow cytometry...
  4. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003;423:762-9 pubmed
    ..Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning...
  5. Collins S, Luan J, Thompson A, Daly A, Semple R, O Rahilly S, et al. Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations. Diabetologia. 2007;50:555-62 pubmed
    ..Exons and splice junctions of the adiponectin receptor 1 and 2 genes (ADIPOR1; ADIPOR2) were sequenced in patients from our severe insulin resistance cohort (n=129)...
  6. Damcott C, Ott S, Pollin T, Reinhart L, Wang J, O Connell J, et al. Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish. Diabetes. 2005;54:2245-50 pubmed
    Adiponectin receptor 1 (ADIPOR1) and adiponectin receptor 2 (ADIPOR2) are newly identified receptors for adiponectin, an adipocytokine with anti-inflammatory and insulin-sensitizing properties...
  7. Qi L, Doria A, Giorgi E, Hu F. Variations in adiponectin receptor genes and susceptibility to type 2 diabetes in women: a tagging-single nucleotide polymorphism haplotype analysis. Diabetes. 2007;56:1586-91 pubmed
    ..The metabolic effects of adiponectin are mediated by adiponectin receptors 1 (ADIPOR1) and 2 (ADIPOR2)...
  8. Civitarese A, Jenkinson C, Richardson D, Bajaj M, Cusi K, Kashyap S, et al. Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes. Diabetologia. 2004;47:816-20 pubmed
    The recent discovery of two adiponectin receptors (AdipoR1 and AdipoR2) will improve our understanding of the molecular mechanisms underlying the insulin-sensitising effect of adiponectin...
  9. Kollias A, Tsiotra P, Ikonomidis I, Maratou E, Mitrou P, Kyriazi E, et al. Adiponectin levels and expression of adiponectin receptors in isolated monocytes from overweight patients with coronary artery disease. Cardiovasc Diabetol. 2011;10:14 pubmed publisher
    ..We aimed to determine adiponectin levels and expression of its receptors (AdipoR1 and AdipoR2) in peripheral monocytes from overweight and obese patients with coronary artery disease (CAD)...

More Information

Publications95

  1. Lopez Bermejo A, Botas Cervero P, Ortega Delgado F, Delgado E, Garcia Gil M, Funahashi T, et al. Association of ADIPOR2 with liver function tests in type 2 diabetic subjects. Obesity (Silver Spring). 2008;16:2308-13 pubmed publisher
    ..We studied whether common single-nucleotide polymorphisms (SNPs) in ADIPOR1 and ADIPOR2 are associated with liver function tests (LFTs) in human subjects with various degrees of insulin resistance...
  2. Rasmussen Torvik L, Pankow J, Jacobs D, Steinberger J, Moran A, Sinaiko A. The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. Hum Genet. 2009;125:21-8 pubmed publisher
    ..have examined the association of SNPs in the adiponectin (ADIPOQ) and adiponectin receptor 1 and 2 (ADIPOR1, ADIPOR2) genes with the euglycemic clamp, i.e. the gold standard measure of insulin sensitivity...
  3. Richards J, Liu Z, Kawai T, Tabata K, Watanabe H, Suresh D, et al. Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility, and early embryo development in the mouse and human. Fertil Steril. 2012;98:471-9.e1 pubmed publisher
    ..Adiponectin differentially alters the expression of Adipor1/Adipor2 as well as genes related to steroidogenesis, ovulation, and apoptosis in cumulus cells versus granulosa cells...
  4. Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, et al. Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes. Diabetologia. 2005;48:1307-14 pubmed
    ..We recently cloned the genes encoding two adiponectin receptors (ADIPOR1 and ADIPOR2)...
  5. Buechler C, Wanninger J, Neumeier M. Adiponectin receptor binding proteins--recent advances in elucidating adiponectin signalling pathways. FEBS Lett. 2010;584:4280-6 pubmed publisher
    ..Adiponectin binds to adiponectin receptors, AdipoR1 and AdipoR2, which are ubiquitously expressed...
  6. Potapov V, Chistiakov D, Dubinina A, Shamkhalova M, Shestakova M, Nosikov V. Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes. Rev Diabet Stud. 2008;5:28-37 pubmed publisher
    ..Genetic variations in adiponectin (ADIPOQ) and adiponectin 1 and 2 receptor (ADIPOR1 and ADIPOR2) could have effects on IR-related phenotypes and T2D...
  7. Staiger H, Kaltenbach S, Staiger K, Stefan N, Fritsche A, Guirguis A, et al. Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism. Diabetes. 2004;53:2195-201 pubmed
    The adiponectin receptors, AdipoR1 and AdipoR2, are thought to transmit the insulin-sensitizing, anti-inflammatory, and atheroprotective effects of adiponectin...
  8. Wang Y, Zhang D, Liu Y, Yang Y, Zhao T, Xu J, et al. Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese. J Genet Genomics. 2009;36:417-23 pubmed publisher
    Single-nucleotide polymorphisms (SNPs) of ADIPOQ, ADIPOR1, and ADIPOR2 have been associated with type 2 diabetes mellitus (T2DM), but there are many conflicting results especially in Chinese populations...
  9. Broedl U, Lehrke M, Fleischer Brielmaier E, Tietz A, Nagel J, Goke B, et al. Genetic variants of adiponectin receptor 2 are associated with increased adiponectin levels and decreased triglyceride/VLDL levels in patients with metabolic syndrome. Cardiovasc Diabetol. 2006;5:11 pubmed
    ..These effects are assumed to be mediated by the recently discovered adiponectin receptors AdipoR1 and AdipoR2. The purpose of this study was to determine whether variations in the AdipoR1 and AdipoR2 genes may contribute to ..
  10. Tan B, Chen J, Digby J, Keay S, Kennedy C, Randeva H. Upregulation of adiponectin receptor 1 and 2 mRNA and protein in adipose tissue and adipocytes in insulin-resistant women with polycystic ovary syndrome. Diabetologia. 2006;49:2723-8 pubmed
    ..in IR states, exerts its glucose-lowering and anti-inflammatory effects by activating two receptors, ADIPOR1 and ADIPOR2. There are no data on the relative expression of these receptors in adipose tissue of PCOS women...
  11. Ferguson J, Phillips C, Tierney A, Perez Martinez P, Defoort C, Helal O, et al. Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance. Am J Clin Nutr. 2010;91:794-801 pubmed publisher
    ..between single nucleotide polymorphisms (SNPs) in the adiponectin gene (ADIPOQ) and its receptors (ADIPOR1 and ADIPOR2) and plasma fatty acid composition and their effects on MetS characteristics...
  12. Vaxillaire M, Dechaume A, Vasseur Delannoy V, Lahmidi S, Vatin V, Lepretre F, et al. Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. Diabetes. 2006;55:856-61 pubmed
    ..and we investigated whether sequence variations in adiponectin receptor 1 (ADIPOR1) and adiponectin receptor 2 (ADIPOR2) genes could contribute to the genetic risk for type 2 diabetes in a case-control study of 1,498 Caucasian ..
  13. Nannipieri M, Cecchetti F, Anselmino M, Mancini E, Marchetti G, Bonotti A, et al. Pattern of expression of adiponectin receptors in human liver and its relation to nonalcoholic steatohepatitis. Obes Surg. 2009;19:467-74 pubmed publisher
    ..assess the role of adiponectin in NASH, we measured expression of adiponectin gene (APM1) and receptors (AdipoR1/AdipoR2) in liver and subcutaneous and visceral fat in subjects with biopsy-proven NASH or pure steatosis (PS)...
  14. Liao Y, Chen L, Zeng T, Zheng J, Li H. Association of the +33371 A/G polymorphism in adiponectin receptor 2 gene with Type 2 diabetes in the Chinese population. J Endocrinol Invest. 2007;30:860-4 pubmed
  15. Richardson D, Schneider J, Fourcaudot M, Rodriguez L, Arya R, Dyer T, et al. Association between variants in the genes for adiponectin and its receptors with insulin resistance syndrome (IRS)-related phenotypes in Mexican Americans. Diabetologia. 2006;49:2317-28 pubmed
    The aim of this study was to examine whether genetic variation in ADIPOQ, ADIPOR1 and ADIPOR2 may contribute to increased susceptibility to components of the insulin resistance syndrome (IRS)...
  16. Siitonen N, Pulkkinen L, Mager U, Lindstrom J, Eriksson J, Valle T, et al. Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study. Diabetologia. 2006;49:1795-805 pubmed
    ..anti-atherogenic effects on target tissues through two known receptors, adiponectin receptors 1 and 2 (ADIPOR1; ADIPOR2), which are encoded by the genes ADIPOR1 and ADIPOR2...
  17. Stefan N, Machicao F, Staiger H, Machann J, Schick F, Tschritter O, et al. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. Diabetologia. 2005;48:2282-91 pubmed
    ..Recently, the genes for mouse and human adiponectin receptor-1 (ADIPOR1) and -2 (ADIPOR2) have been cloned...
  18. Pierre P, Froment P, Negre D, Rame C, Barateau V, Chabrolle C, et al. Role of adiponectin receptors, AdipoR1 and AdipoR2, in the steroidogenesis of the human granulosa tumor cell line, KGN. Hum Reprod. 2009;24:2890-901 pubmed publisher
    ..We have previously shown that adiponectin receptors (AdipoR1 and AdipoR2) are expressed in human granulosa cells...
  19. Mao X, Kikani C, Riojas R, Langlais P, Wang L, Ramos F, et al. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol. 2006;8:516-23 pubmed
    ..Two seven-transmembrane domain-containing proteins, AdipoR1 and AdipoR2, have recently been identified as adiponectin receptors, yet signalling events downstream of these receptors ..
  20. Luo L, Li J, Liu H, Jian X, Zou Q, Zhao Q, et al. Adiponectin Is Involved in Connective Tissue Growth Factor-Induced Proliferation, Migration and Overproduction of the Extracellular Matrix in Keloid Fibroblasts. Int J Mol Sci. 2017;18: pubmed publisher
    ..signalling pathways was attenuated by small interfering RNAs (siRNAs) targeting adipoR1 (but not siRNAs targeting adipoR2, T-cadherin or calreticulin), AMPK (Compound C), p38 (SB203580) inhibitors, and mitogen-activated protein kinase ..
  21. Duval F, Santos E, Poidatz D, Serazin V, Gronier H, Vialard F, et al. Adiponectin Inhibits Nutrient Transporters and Promotes Apoptosis in Human Villous Cytotrophoblasts: Involvement in the Control of Fetal Growth. Biol Reprod. 2016;94:111 pubmed publisher
    ..Small-interfering RNA mediating the down-regulation of adiponectin receptors (ADIPOR1 and ADIPOR2) was used to demonstrate that adiponectin effects on placental nutrient transport and apoptosis seemed to be ..
  22. Fu C, Liu L, Li F. Acetate alters the process of lipid metabolism in rabbits. Animal. 2017;:1-8 pubmed publisher
    ..GPR41), GPR43, adenosine monophosphate-activated protein kinase ?1 (AMPK?1), adiponectin receptor (AdipoR1), AdipoR2 and leptin receptor...
  23. Heritage M, Jaskowski L, Bridle K, Campbell C, Briskey D, Britton L, et al. Combination curcumin and vitamin E treatment attenuates diet-induced steatosis in Hfe-/- mice. World J Gastrointest Pathophysiol. 2017;8:67-76 pubmed publisher
    ..Combination therapy increased the mRNA expression of AdipoR2, Ppar-?, Cpt1a, Nrf-1 and Tfb2m suggesting enhanced fatty acid oxidation and mitochondrial ..
  24. Chen H, Yang C, Chang J, Wu C, Sia K, Lin W. AdipoR-increased intracellular ROS promotes cPLA2 and COX-2 expressions via activation of PKC and p300 in adiponectin-stimulated human alveolar type II cells. Am J Physiol Lung Cell Mol Physiol. 2016;311:L255-69 pubmed publisher
    ..Understanding the adiponectin signaling pathways on regulating cPLA2 and COX-2 may help develop therapeutic strategies on pulmonary diseases. ..
  25. Urbanek M, Hayes M, Lee H, Freathy R, Lowe L, Ackerman C, et al. The role of inflammatory pathway genetic variation on maternal metabolic phenotypes during pregnancy. PLoS ONE. 2012;7:e32958 pubmed publisher
    ..6 mg/dl decrease per allele T; p-value = 1.3×10(-4)), ADIPOR2 and fasting C-peptide (rs2041139; 0.55 ug/L decrease per allele A; p-value = 1...
  26. Solayman M, Saleh M, Paul S, Khalil M, Gan S. In silico analysis of nonsynonymous single nucleotide polymorphisms of the human adiponectin receptor 2 (ADIPOR2) gene. Comput Biol Chem. 2017;68:175-185 pubmed publisher
    Polymorphisms of the ADIPOR2 gene are frequently linked to a higher risk of developing diseases including obesity, type 2 diabetes and cardiovascular diseases...
  27. Makina S, Muchadeyi F, van Marle Köster E, Taylor J, Makgahlela M, Maiwashe A. Genome-wide scan for selection signatures in six cattle breeds in South Africa. Genet Sel Evol. 2015;47:92 pubmed publisher
    ..immune response (CYM, CDC6, and CDK10), production (MTPN, IGFBP4, TGFB1, and AJAP1) and reproductive performance (ADIPOR2, OVOS2, and RBBP8) were also detected as being under selection...
  28. Bai M, Sun L, Zhao J, Xiang L, Cheng X, Li J, et al. Histological analysis and identification of spermatogenesis-related genes in 2-, 6-, and 12-month-old sheep testes. Naturwissenschaften. 2017;104:84 pubmed publisher
    ..The expression of 13 DEGs (CA3, APOH, MYOC, CATSPER4, SYT6, SERPINA10, DAZL, ADIPOR2, RAB13, CEP41, SPAG4, ODF1, and FRG1) was validated by RT-PCR.
  29. Ayyildiz T, Dolar E, Ugras N, Dizdar O, Adim S, Yerci O. Lack of any prognostic relationship between adiponectin receptor (Adipo R1/R2) expression for early/advanced stage gastric cancer. Asian Pac J Cancer Prev. 2014;15:4711-6 pubmed
    ..054), there was no relationship between Adipo-R1/-R2 expression with tumor stage and survival. Adipo-R1/-R2 expression has no prognostic significance of in early/advanced stage gastric cancer. ..
  30. Ruchat S, Loos R, Rankinen T, Vohl M, Weisnagel S, Despres J, et al. Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study. Diabet Med. 2008;25:400-6 pubmed publisher
    Studies suggest that adiponectin (APM1) and its receptors 1 and 2 (AdipoR1 and AdipoR2) play an important role in the development of insulin resistance (IR)...
  31. Shin E, Yu Y, Kim D, Won N. Adiponectin receptor expression predicts favorable prognosis in cases of hepatocellular carcinoma. Pathol Oncol Res. 2014;20:667-75 pubmed publisher
    ..on obesity-related malignancies, though variable signal pathway mediated by adiponectin receptors-AdipoR1 and AdipoR2. In this study, we investigated expression of adiponectin and adiponectin receptors in tumor and non-tumorous ..
  32. Bermúdez V, Rojas E, Toledo A, Rodríguez Molina D, Vega K, Suarez L, et al. Single-nucleotide polymorphisms in adiponectin, AdipoR1, and AdipoR2 genes: insulin resistance and type 2 diabetes mellitus candidate genes. Am J Ther. 2013;20:414-21 pubmed publisher
    ..discovery of adiponectin and its role as an insulin sensitizer and only 7 years since its receptors, AdipoR1 and AdipoR2, were described...
  33. Neumeier M, Hellerbrand C, Gabele E, Buettner R, Bollheimer C, Weigert J, et al. Adiponectin and its receptors in rodent models of fatty liver disease and liver cirrhosis. World J Gastroenterol. 2006;12:5490-4 pubmed
    ..liver cirrhosis and investigate expression of the adiponectin receptors AdipoR1 on the mRNA and protein level and AdipoR2 on the mRNA level...
  34. McCormack M, Urban T, Shianna K, Walley N, Pandolfo M, Depondt C, et al. Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. Pharmacogenomics. 2012;13:399-405 pubmed publisher
    ..As a predictive marker, HLA-A*3101 appears to be specific for carbamazepine-induced cADRs. ..
  35. Pilon M. Revisiting the membrane-centric view of diabetes. Lipids Health Dis. 2016;15:167 pubmed
    ..elegans homologs of the anti-diabetic adiponectin receptors (AdipoR1 and AdipoR2) has led us to exciting new discoveries and to revisit what may be termed "The Membrane Theory of Diabetes"...
  36. Engin A. Adiponectin-Resistance in Obesity. Adv Exp Med Biol. 2017;960:415-441 pubmed publisher
    ..domain, and leucine zipper motif 1 (APPL1) is the intracellular binding partner of AdipoR1 and AdipoR2. The expression levels of APPL1 or APPL2 lead to an altered adiponectin activity...
  37. Basu S, Combe K, Kwiatkowski F, Caldefie Chézet F, Penault Llorca F, Bignon Y, et al. Cellular Expression of Cyclooxygenase, Aromatase, Adipokines, Inflammation and Cell Proliferation Markers in Breast Cancer Specimen. PLoS ONE. 2015;10:e0138443 pubmed publisher
    ..to the tumor compared to tumor specimens when considering either score or staining area whereas COX-2 and AdipoR2 were found to be higher considering staining intensity and Ki67 on score level in the tumor tissue...
  38. Kim Y, Lim J, Kim M, Kim E, Yoon H, Shin S, et al. The Adiponectin Receptor Agonist AdipoRon Ameliorates Diabetic Nephropathy in a Model of Type 2 Diabetes. J Am Soc Nephrol. 2018;29:1108-1127 pubmed publisher
    ..Expression of AdipoR1, AdipoR2, and Ca2+/calmodulin-dependent protein kinase kinase-β (CaMKKβ) and numbers of ..
  39. Lim W, Choi M, Bae H, Bazer F, Song G. A critical role for adiponectin-mediated development of endometrial luminal epithelial cells during the peri-implantation period of pregnancy. J Cell Physiol. 2017;232:3146-3157 pubmed publisher
    ..Its receptors (ADIPOR1 and ADIPOR2) are widely expressed in mammalian tissues, including porcine conceptuses and endometrial during the estrous ..
  40. Yunusova N, Spirina L, Frolova A, Afanas ev S, Kolegova E, Kondakova I. Association of IGFBP-6 Expression with Metabolic Syndrome and Adiponectin and IGF-IR Receptor Levels in Colorectal Cancer. Asian Pac J Cancer Prev. 2016;17:3963-9 pubmed
    ..IGFBP-6 expression in relation with the presence of the metabolic syndrome, adiponectin receptors (AdipoR1 and AdipoR2) and IGF-IR levels in colorectal adenocarcinoma cases...
  41. Dieudonne M, Bussiere M, Dos Santos E, Leneveu M, Giudicelli Y, Pecquery R. Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells. Biochem Biophys Res Commun. 2006;345:271-9 pubmed
    ..Moreover, adipose adiponectin production being strongly reduced in obesity, this study may help to explain why obesity is a risk factor of developing breast cancers. ..
  42. Ma H, Gomez V, Lu L, Yang X, Wu X, Xiao S. Expression of adiponectin and its receptors in livers of morbidly obese patients with non-alcoholic fatty liver disease. J Gastroenterol Hepatol. 2009;24:233-7 pubmed publisher
    ..These findings indicate that decreased liver adiponectin expression may play a role in the development and progression of NAFLD, from simple steatosis to NASH, in morbidly obese patients. ..
  43. Artimani T, Saidijam M, Aflatoonian R, Ashrafi M, Amiri I, Yavangi M, et al. Downregulation of adiponectin system in granulosa cells and low levels of HMW adiponectin in PCOS. J Assist Reprod Genet. 2016;33:101-10 pubmed publisher
    ..Adiponectin (Adipo), adiponectin receptor 1 (AdipoR1), and adiponectin receptor 2 (AdipoR2) messenger RNA (mRNA) expression levels were measured using quantitative real-time polymerase chain reaction (qRT-..
  44. Dhillon P, Penney K, Schumacher F, Rider J, Sesso H, Pollak M, et al. Common polymorphisms in the adiponectin and its receptor genes, adiponectin levels and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2011;20:2618-27 pubmed publisher
    ..Study, we evaluated 29 common single-nucleotide polymorphisms (SNP) in ADIPOQ (n = 13), ADIPOR1 (n = 5), and ADIPOR2 (n = 11) in relation to the risk of prostate cancer...
  45. Kitajima K, Miura S, Yamauchi T, Uehara Y, Kiya Y, Rye K, et al. Possibility of increasing cholesterol efflux by adiponectin and its receptors through the ATP binding cassette transporter A1 in HEK293T cells. Biochem Biophys Res Commun. 2011;411:305-11 pubmed publisher
    ..We transfected adiponectin receptor 1 and 2 (AdipoR1 and AdipoR2) cDNA into cells...
  46. Ikonomidis I, Kadoglou N, Tsiotra P, Kollias A, Palios I, Fountoulaki K, et al. Arterial stiffness is associated with increased monocyte expression of adiponectin receptor mRNA and protein in patients with coronary artery disease. Am J Hypertens. 2012;25:746-55 pubmed publisher
    ..Adiponectin and its receptors 1 (AdipoR1) and 2 (AdipoR2) are involved in coronary artery disease (CAD)...
  47. Alzahrani B, Iseli T, Ramezani Moghadam M, Ho V, Wankell M, Sun E, et al. The role of AdipoR1 and AdipoR2 in liver fibrosis. Biochim Biophys Acta Mol Basis Dis. 2018;1864:700-708 pubmed publisher
    ..However, understanding of the role of AdipoR1 and AdipoR2 in mediating this response is still rudimentary...
  48. Zhang R, Lin Y, Zhi L, Liao H, Zuo L, Li Z, et al. Expression profiles and associations of adiponectin and adiponectin receptors with intramuscular fat in Tibetan chicken. Br Poult Sci. 2017;58:151-157 pubmed publisher
    1. Adiponectin and its receptors (ADIPOR1 and ADIPOR2) are novel endocrine systems that act at various levels to modulate glucose and lipid metabolism...
  49. Koh I, Lim J, Joe M, Kim W, Jung M, Yoon J, et al. AdipoR2 is transcriptionally regulated by ER stress-inducible ATF3 in HepG2 human hepatocyte cells. FEBS J. 2010;277:2304-17 pubmed publisher
    ..We found that the hepatic expression of adiponectin receptor 2 (AdipoR2) was lower, but the expression of markers of the ER stress pathway, 78 kDa glucose-regulated protein (GRP78) and ..
  50. Sun Z, Zhou J. [Mechanism of action of the SIRT1-FoxO1-AdipoR2 signaling pathway in alcoholic fatty liver disease]. Zhonghua Gan Zang Bing Za Zhi. 2016;24:877-880 pubmed publisher
  51. Lee M, Klein R, El Shewy H, Luttrell D, Luttrell L. The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth. Biochemistry. 2008;47:11682-92 pubmed publisher
    ..These results suggest that adiponectin can exert proliferative effects by activating Ras signaling pathways. ..
  52. Tie Weiwei -, Yu Haiyan -, Chen Juan -, Wang Xiaodong -, Chen Weibo -, Zhou Rong -. Expressions of adiponectin receptors in placenta and their correlation with preeclampsia. Reprod Sci. 2009;16:676-84 pubmed publisher
    ..05). Nonetheless, both the protein and mRNA levels were significantly higher in comparison to those of the normal group (P < .05). The abnormality of Adipo-R2 may be associated with the pathogenesis of preeclampsia. ..
  53. Chiu Y, Shieh D, Tong K, Chen C, Huang K, Chen P, et al. Involvement of AdipoR receptor in adiponectin-induced motility and alpha2beta1 integrin upregulation in human chondrosarcoma cells. Carcinogenesis. 2009;30:1651-9 pubmed publisher
    ..The protein and messenger RNA expression of adiponectin receptor (AdipoR1 and AdipoR2) in chondrosarcoma patients and chondrosarcoma cell lines were significantly higher than the normal cartilage...
  54. Rahman S, Qadri I, Janssen R, Friedman J. Fenofibrate and PBA prevent fatty acid-induced loss of adiponectin receptor and pAMPK in human hepatoma cells and in hepatitis C virus-induced steatosis. J Lipid Res. 2009;50:2193-202 pubmed publisher
    ..loading, endoplasmic reticulum (ER) stress, and the hypolipidemic agent fenofibrate on adiponectin receptor R2 (AdipoR2) levels and AMP-activated protein kinase (AMPK) in human hepatoma Huh7 cells and in Huh...
  55. Ozturk K, Avcu F, Ural A. Aberrant expressions of leptin and adiponectin receptor isoforms in chronic myeloid leukemia patients. Cytokine. 2012;57:61-7 pubmed publisher
    ..of leptin receptor isoforms, OB-Rt, OB-Ra, and OB-Rb, and the expression of adiponectin receptors, AdipoR1 and AdipoR2, were measured as mRNA levels in two CML cell lines (K562 and Meg-01) and 20 CML patients and 24 healthy controls ..
  56. VanSaun M. Molecular pathways: adiponectin and leptin signaling in cancer. Clin Cancer Res. 2013;19:1926-32 pubmed publisher
    ..This review addresses the current level of understanding of molecular pathways activated by adiponectin and leptin to identify the areas of intervention and facilitate advancement in the field. ..
  57. Gómez Abellán P, Gomez Santos C, Madrid J, Milagro F, Campion J, Martinez J, et al. Circadian expression of adiponectin and its receptors in human adipose tissue. Endocrinology. 2010;151:115-22 pubmed publisher
    ..To assess whether the mRNA levels of adiponectin and its receptors (ADIPOR1 and ADIPOR2) might show daily circadian rhythms in visceral and sc fat explants obtained from morbid obese women, visceral ..
  58. Vasiliauskaité Brooks I, Sounier R, Rochaix P, Bellot G, Fortier M, Hoh F, et al. Structural insights into adiponectin receptors suggest ceramidase activity. Nature. 2017;544:120-123 pubmed publisher
    ..The crystal structures of the two receptor subtypes, ADIPOR1 and ADIPOR2, show a similar overall seven-transmembrane-domain architecture with large unoccupied cavities and a zinc binding ..
  59. Guan G, Zhang D, Zheng Y, Wen L, Yu D, Lu Y, et al. microRNA-423-3p promotes tumor progression via modulation of AdipoR2 in laryngeal carcinoma. Int J Clin Exp Pathol. 2014;7:5683-91 pubmed
    ..By using in silico prediction algorithms for target identification, AdipoR2 (adiponectin receptor 2) and DUSP4 (MAP kinase phosphatase 2) were identified to be potential targets of miR-423-..
  60. Ishikawa M, Kitayama J, Yamauchi T, Kadowaki T, Maki T, Miyato H, et al. Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2. Cancer Sci. 2007;98:1120-7 pubmed
    ..In this study, we examined the expression of adiponectin receptors (AdipoR1 and AdipoR2) and assessed the function of adiponectin in gastric cancer...
  61. Keshvari S, Rose F, Charlton H, Scheiber N, Webster J, Kim Y, et al. Characterisation of the adiponectin receptors: the non-conserved N-terminal region of AdipoR2 prevents its expression at the cell-surface. Biochem Biophys Res Commun. 2013;432:28-33 pubmed publisher
    ..In the current report we have used C-terminal, epitope-tagged AdipoR1 and AdipoR2 constructs to monitor cell-surface expression by indirect immunofluorescence microscopy and quantitative plate-..
  62. Byeon J, Jeong J, Kim M, Lee S, Nam W, Myung S, et al. Adiponectin and adiponectin receptor in relation to colorectal cancer progression. Int J Cancer. 2010;127:2758-67 pubmed publisher
    ..Adiponectin is an adipokine that binds to 2 types of receptors, AdipoR1 and AdipoR2. The plasma concentrations of adiponectin are reduced in obese individuals and adiponectin has been reported to ..
  63. Dorfman R, Li W, Sun L, Lin F, Wang Y, Sandford A, et al. Modifier gene study of meconium ileus in cystic fibrosis: statistical considerations and gene mapping results. Hum Genet. 2009;126:763-78 pubmed publisher
    ..sample of pancreatic insufficient Canadian CF patients with and without MI pointed to the involvement of ADIPOR2 in MI (p = 0.002)...
  64. Miyazawa M, Subbaramaiah K, Bhardwaj P, Zhou X, Wang H, Falcone D, et al. Pioglitazone Inhibits Periprostatic White Adipose Tissue Inflammation in Obese Mice. Cancer Prev Res (Phila). 2018;11:215-226 pubmed publisher
    ..caused dose-dependent induction of both adiponectin, an anti-inflammatory adipokine, and its receptor AdipoR2 in cultured 3T3-L1 cells and in periprostatic WAT of obese mice...
  65. Namvaran F, Rahimi Moghaddam P, Azarpira N, Dabbaghmanesh M. Polymorphism of adiponectin (45T/G) and adiponectin receptor-2 (795G/A) in an Iranian population: relation with insulin resistance and response to treatment with pioglitazone in patients with type 2 diabetes mellitus. Mol Biol Rep. 2012;39:5511-8 pubmed publisher
    ..However, adiponectin 45T/G and adiponectin receptor-2 795G/A polymorphisms were not significantly associated with the response to pioglitazone in our sample. ..
  66. Shin E, Park D, Kim H, Won N, Choe G, Lee H. Adiponectin receptor expression in gastric carcinoma: implications in tumor development and progression. J Cancer Res Clin Oncol. 2013;139:709-18 pubmed publisher
    ..Expression of adiponectin receptors--AdipoR1 and AdipoR2--has been documented in gastric cancer (GC) cell lines, but its role in GCs is still controversial...
  67. Teras L, Goodman M, Patel A, Bouzyk M, Tang W, Diver W, et al. No association between polymorphisms in LEP, LEPR, ADIPOQ, ADIPOR1, or ADIPOR2 and postmenopausal breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2009;18:2553-7 pubmed publisher
  68. Punyadeera C, Zorenc A, Koopman R, McAinch A, Smit E, Manders R, et al. The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle. Eur J Endocrinol. 2005;152:427-36 pubmed
    ..Adiponectin is abundantly expressed in muscle, and, for the first time, it has been shown to be present in/on the sarcolemma of individual muscle fibres. ..
  69. Takemura Y, Osuga Y, Yamauchi T, Kobayashi M, Harada M, Hirata T, et al. Expression of adiponectin receptors and its possible implication in the human endometrium. Endocrinology. 2006;147:3203-10 pubmed
    Adiponectin, a pleiotropic cytokine, exerts its effects via the specific receptors AdipoR1 and AdipoR2. Whereas circulating adiponectin concentrations decrease in women with endometriosis and endometrial cancer, possible effects of ..
  70. Liu J, Sui H, Zhao J, Wang Y. Osmotin Protects H9c2 Cells from Simulated Ischemia-Reperfusion Injury through AdipoR1/PI3K/AKT Signaling Pathway. Front Physiol. 2017;8:611 pubmed publisher
    ..05). However, these effects were markedly reversed by AdipoR1 silence but not AdipoR2. Furthermore, osmotin dramatically upregulated the phosphorylation levels of PI3K, AKT, ERK, and downregulated ..
  71. Sun X, Han R, Wang Z, Chen Y. Regulation of adiponectin receptors in hepatocytes by the peroxisome proliferator-activated receptor-gamma agonist rosiglitazone. Diabetologia. 2006;49:1303-10 pubmed
    ..critical role in the development of type 2 diabetes via interaction with adiponectin receptors 1 (ADIPOR1) and 2 (ADIPOR2)...
  72. Miljkovic I, Yerges Armstrong L, Kuller L, Kuipers A, Wang X, Kammerer C, et al. Association analysis of 33 lipoprotein candidate genes in multi-generational families of African ancestry. J Lipid Res. 2010;51:1823-31 pubmed publisher
    ..Future sequencing and functional studies of these loci may advance our understanding of genetic factors contributing to LDL-C in African ancestry populations. ..
  73. Tan P, Tyrrell H, Gao L, Xu D, Quan J, Gill D, et al. Adiponectin receptor signaling on dendritic cells blunts antitumor immunity. Cancer Res. 2014;74:5711-22 pubmed publisher
    ..with metastatic or locally advanced breast cancer express high levels of the adiponectin receptors AdipoR1 and AdipoR2, which are sufficient to blunt antitumor immunity...
  74. Ayyildiz T, Dolar E, Ugras N, Emınler A, Erturk B, Adim S, et al. Adipo-R1 and adipo-R2 expression in colorectal adenomas and carcinomas. Asian Pac J Cancer Prev. 2015;16:367-72 pubmed
    ..001, p=0.004, p<0.001, respectively). This study indicated that ApN may play a role in the progression of colorectal adenomatous polyps to carcinoma through actions on adipo-R1 and adipo-R2 receptors. ..
  75. Bohlouli S, Rabzia A, Sadeghi E, Chobsaz F, Khazaei M. in vitro Anti-Proliferative Effect of Adiponectin on Human Endometriotic Stromal Cells through AdipoR1 and AdipoR2 Gene Receptor Expression. Iran Biomed J. 2016;20:12-7 pubmed
    ..001). Expression of AdipoR1 and AdipoR2 gene receptors was increased in human ESCs significantly (P<0.05)...
  76. Coletta D, Schneider J, Hu S, Dyer T, Puppala S, Farook V, et al. Genome-wide linkage scan for genes influencing plasma triglyceride levels in the Veterans Administration Genetic Epidemiology Study. Diabetes. 2009;58:279-84 pubmed publisher
    ..8, empirical P value = 2.0 x 10(-5)). This region on 12p harbors the gene-encoding adiponectin receptor 2 (AdipoR2), where we previously have shown that multiple single nucleotide polymorphisms are associated with plasma ..
  77. Pacheco Pantoja E, Fraser W, Wilson P, Gallagher J. Differential effects of adiponectin in osteoblast-like cells. J Recept Signal Transduct Res. 2014;34:351-60 pubmed publisher
    ..We studied the presence of adiponectin receptors (AdipoR1, AdipoR2) and its direct effects in osteosarcoma cell line Saos-2...
  78. Zha D, Wu X, Gao P. Adiponectin and Its Receptors in Diabetic Kidney Disease: Molecular Mechanisms and Clinical Potential. Endocrinology. 2017;158:2022-2034 pubmed publisher
    ..Two types of adiponectin receptors, AdipoR1 and AdipoR2, have been identified...
  79. Pang T, Chimen M, Goble E, Dixon N, Benbow A, Eldershaw S, et al. Inhibition of islet immunoreactivity by adiponectin is attenuated in human type 1 diabetes. J Clin Endocrinol Metab. 2013;98:E418-28 pubmed publisher
    ..Furthermore, we suggest that interventions that reduce insulin resistance could modulate the inflammatory process in T1D. ..
  80. Keshvari S, Whitehead J. Characterisation of the adiponectin receptors: Differential cell-surface expression and temporal signalling profiles of AdipoR1 and AdipoR2 are regulated by the non-conserved N-terminal trunks. Mol Cell Endocrinol. 2015;409:121-9 pubmed publisher
    ..Rudimentary understanding of the adiponectin receptors, AdipoR1 and AdipoR2, constrains our ability to target these atypical seven trans-membrane proteins...
  81. Mora García G, Ruiz Díaz M, Espitia Almeida F, Gómez Camargo D. Variations in ADIPOR1 But Not ADIPOR2 are Associated With Hypertriglyceridemia and Diabetes in an Admixed Latin American Population. Rev Diabet Stud. 2017;14:311-328 pubmed publisher
    ..Its activity is mainly mediated by the transmembrane receptors AdipoR1 and AdipoR2, which are encoded by ADIPOR1 (1q32.1) and ADIPOR2 (12p13.33) genes, respectively...
  82. Castilhos J, Sprinz E, Lazzaretti R, Kuhmmer R, Mattevi V. Polymorphisms in adiponectin receptor genes are associated with lipodystrophy-related phenotypes in HIV-infected patients receiving antiretroviral therapy. HIV Med. 2015;16:494-501 pubmed publisher
    ..association between genetic variability in the adiponectin receptor genes ADIPOR1 (adiponectin receptor 1) and ADIPOR2 and lipodystrophy and its related anthropometric and metabolic phenotypes in HIV-infected patients on highly ..
  83. Lin T, Qiu Y, Liu Y, MOHAN R, Li Q, Lei B. Expression of adiponectin and its receptors in type 1 diabetes mellitus in human and mouse retinas. Mol Vis. 2013;19:1769-78 pubmed
    ..05 regarded as statistically significant. APN, AdipoR1, and AdipoR2 were identified in the neural retina and in the RPE-choroid of humans and mice...
  84. Flores Y, Velázquez Cruz R, Ramirez P, Bañuelos M, Zhang Z, Yee H, et al. Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults. Mol Biol Rep. 2016;43:1359-1369 pubmed
    ..to investigate nine SNPs in or near the following genes: PNPLA3, LYPLAL1, PPP1R3B, GCKR, NCAN, IRS1, PPARG, and ADIPOR2 and examine their association with persistently elevated alanine aminotransferase (ALT) or aspartate ..
  85. Cheng S, Liu C, Hsu Y, Chang Y, Huang S, Lee J. Expression and biologic significance of adiponectin receptors in papillary thyroid carcinoma. Cell Biochem Biophys. 2013;65:203-10 pubmed publisher
    ..study aimed to investigate the possible association between the expression of adiponectin receptors (AdipoR1 and AdipoR2) and clinicopathological variables in papillary thyroid cancer...
  86. Dalamaga M, Migdalis I, Fargnoli J, Papadavid E, Bloom E, Mitsiades N, et al. Pancreatic cancer expresses adiponectin receptors and is associated with hypoleptinemia and hyperadiponectinemia: a case-control study. Cancer Causes Control. 2009;20:625-33 pubmed publisher
    ..5% had positive or strong positive expression of AdipoR1 and 93.7% had positive or strong positive expression of AdipoR2. Further prospective studies are needed to determine whether the elevated adiponectin and low leptin levels ..