ADIPOR1

Summary

Gene Symbol: ADIPOR1
Description: adiponectin receptor 1
Alias: ACDCR1, CGI-45, CGI45, PAQR1, TESBP1A, adiponectin receptor protein 1, progestin and adipoQ receptor family member 1, progestin and adipoQ receptor family member I
Species: human
Products:     ADIPOR1

Top Publications

  1. Pang T, Narendran P. The distribution of adiponectin receptors on human peripheral blood mononuclear cells. Ann N Y Acad Sci. 2008;1150:143-5 pubmed publisher
    ..Its actions are mediated by two receptors, adiponectin receptors 1 (ADIPOR1) and 2 (ADIPOR2)...
  2. Ishikawa M, Kitayama J, Yamauchi T, Kadowaki T, Maki T, Miyato H, et al. Adiponectin inhibits the growth and peritoneal metastasis of gastric cancer through its specific membrane receptors AdipoR1 and AdipoR2. Cancer Sci. 2007;98:1120-7 pubmed
    ..In this study, we examined the expression of adiponectin receptors (AdipoR1 and AdipoR2) and assessed the function of adiponectin in gastric cancer...
  3. Civitarese A, Jenkinson C, Richardson D, Bajaj M, Cusi K, Kashyap S, et al. Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes. Diabetologia. 2004;47:816-20 pubmed
    The recent discovery of two adiponectin receptors (AdipoR1 and AdipoR2) will improve our understanding of the molecular mechanisms underlying the insulin-sensitising effect of adiponectin...
  4. Dhillon P, Penney K, Schumacher F, Rider J, Sesso H, Pollak M, et al. Common polymorphisms in the adiponectin and its receptor genes, adiponectin levels and the risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 2011;20:2618-27 pubmed publisher
    ..However, the role of genetic variation in the adiponectin (ADIPOQ) and receptor genes (ADIPOR1/R2) in prostate cancer is largely unknown...
  5. Kaklamani V, Wisinski K, Sadim M, Gulden C, Do A, Offit K, et al. Variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes and colorectal cancer risk. JAMA. 2008;300:1523-31 pubmed publisher
    ..haplotype-tagging single-nucleotide polymorphisms (SNPs) of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes with colorectal cancer risk...
  6. Lee W, Rhee E, Oh K, Kim S, Jung C, Yun E, et al. Identification of adiponectin and its receptors in human osteoblast-like cells and association of T45G polymorphism in exon 2 of adiponectin gene with lumbar spine bone mineral density in Korean women. Clin Endocrinol (Oxf). 2006;65:631-7 pubmed
    ..We found that the mRNAs for adiponectin and for adiponectin receptor 1 (AdipoR1) and 2 (AdipoR2) were expressed in the MG-63 cells...
  7. Wang Y, Zhang D, Liu Y, Yang Y, Zhao T, Xu J, et al. Association study of the single nucleotide polymorphisms in adiponectin-associated genes with type 2 diabetes in Han Chinese. J Genet Genomics. 2009;36:417-23 pubmed publisher
    Single-nucleotide polymorphisms (SNPs) of ADIPOQ, ADIPOR1, and ADIPOR2 have been associated with type 2 diabetes mellitus (T2DM), but there are many conflicting results especially in Chinese populations...
  8. Rasmussen Torvik L, Pankow J, Jacobs D, Steinberger J, Moran A, Sinaiko A. The association of SNPs in ADIPOQ, ADIPOR1, and ADIPOR2 with insulin sensitivity in a cohort of adolescents and their parents. Hum Genet. 2009;125:21-8 pubmed publisher
    Few studies have examined the association of SNPs in the adiponectin (ADIPOQ) and adiponectin receptor 1 and 2 (ADIPOR1, ADIPOR2) genes with the euglycemic clamp, i.e. the gold standard measure of insulin sensitivity...
  9. Liu L, Zhong R, Wei S, Yin J, Xiang H, Zou L, et al. Interactions between genetic variants in the adiponectin, adiponectin receptor 1 and environmental factors on the risk of colorectal cancer. PLoS ONE. 2011;6:e27301 pubmed publisher
    ..we evaluated 24 tag single nucleotide polymorphisms (tag SNPs) across ADIPOQ ligand and two ADIPOQ receptors (ADIPOR1 and ADIPOR2) among 470 cases and 458 controls...

More Information

Publications79

  1. Bluher M, Williams C, Kloting N, Hsi A, Ruschke K, Oberbach A, et al. Gene expression of adiponectin receptors in human visceral and subcutaneous adipose tissue is related to insulin resistance and metabolic parameters and is altered in response to physical training. Diabetes Care. 2007;30:3110-5 pubmed
    Adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2, respectively) mediate the effects of adiponectin on glucose and lipid metabolism in vivo...
  2. Crimmins N, Woo J, Kaushal R, Deka R, Dolan L, Martin L. Adiponectin receptor 1 variants associated with lower insulin resistance in African Americans. Obesity (Silver Spring). 2007;15:1903-7 pubmed
    ..However, little is known about the contribution of genetic variation in the adiponectin receptor 1 gene (ADIPOR1) in this regard...
  3. Mao X, Kikani C, Riojas R, Langlais P, Wang L, Ramos F, et al. APPL1 binds to adiponectin receptors and mediates adiponectin signalling and function. Nat Cell Biol. 2006;8:516-23 pubmed
    ..Two seven-transmembrane domain-containing proteins, AdipoR1 and AdipoR2, have recently been identified as adiponectin receptors, yet signalling events downstream of these ..
  4. Hara K, Horikoshi M, Kitazato H, Yamauchi T, Ito C, Noda M, et al. Absence of an association between the polymorphisms in the genes encoding adiponectin receptors and type 2 diabetes. Diabetologia. 2005;48:1307-14 pubmed
    ..We recently cloned the genes encoding two adiponectin receptors (ADIPOR1 and ADIPOR2)...
  5. Kaklamani V, Yi N, Zhang K, Sadim M, Offit K, Oddoux C, et al. Polymorphisms of ADIPOQ and ADIPOR1 and prostate cancer risk. Metabolism. 2011;60:1234-43 pubmed publisher
    ..haplotype tagging single nucleotide polymorphisms (SNPs) of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) chosen based on their functional relevance or association with other types of cancer...
  6. Yamauchi T, Kamon J, Ito Y, Tsuchida A, Yokomizo T, Kita S, et al. Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature. 2003;423:762-9 pubmed
    ..Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning...
  7. Ogunwobi O, Beales I. Globular adiponectin, acting via adiponectin receptor-1, inhibits leptin-stimulated oesophageal adenocarcinoma cell proliferation. Mol Cell Endocrinol. 2008;285:43-50 pubmed publisher
    ..All four OAC lines expressed both adiponectin-receptor isoforms (AdipoR1 and AdipoR2)...
  8. Ruchat S, Loos R, Rankinen T, Vohl M, Weisnagel S, Despres J, et al. Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study. Diabet Med. 2008;25:400-6 pubmed publisher
    Studies suggest that adiponectin (APM1) and its receptors 1 and 2 (AdipoR1 and AdipoR2) play an important role in the development of insulin resistance (IR)...
  9. Tang Y, Hu T, Arterburn M, Boyle B, Bright J, Emtage P, et al. PAQR proteins: a novel membrane receptor family defined by an ancient 7-transmembrane pass motif. J Mol Evol. 2005;61:372-80 pubmed
  10. Collins S, Luan J, Thompson A, Daly A, Semple R, O Rahilly S, et al. Adiponectin receptor genes: mutation screening in syndromes of insulin resistance and association studies for type 2 diabetes and metabolic traits in UK populations. Diabetologia. 2007;50:555-62 pubmed
    ..Exons and splice junctions of the adiponectin receptor 1 and 2 genes (ADIPOR1; ADIPOR2) were sequenced in patients from our severe insulin resistance cohort (n=129)...
  11. Stefan N, Machicao F, Staiger H, Machann J, Schick F, Tschritter O, et al. Polymorphisms in the gene encoding adiponectin receptor 1 are associated with insulin resistance and high liver fat. Diabetologia. 2005;48:2282-91 pubmed
    ..Recently, the genes for mouse and human adiponectin receptor-1 (ADIPOR1) and -2 (ADIPOR2) have been cloned...
  12. Edwards T, Velez Edwards D, Villegas R, Cohen S, Buchowski M, Fowke J, et al. HTR1B, ADIPOR1, PPARGC1A, and CYP19A1 and obesity in a cohort of Caucasians and African Americans: an evaluation of gene-environment interactions and candidate genes. Am J Epidemiol. 2012;175:11-21 pubmed publisher
    ..Gene-environment interactions were observed with cigarette smoking and a SNP in ADIPOR1 in African Americans, as well as between a different SNP in ADIPOR1 and physical activity in Caucasians...
  13. Vaxillaire M, Dechaume A, Vasseur Delannoy V, Lahmidi S, Vatin V, Lepretre F, et al. Genetic analysis of ADIPOR1 and ADIPOR2 candidate polymorphisms for type 2 diabetes in the Caucasian population. Diabetes. 2006;55:856-61 pubmed
    ..receptors have been identified, and we investigated whether sequence variations in adiponectin receptor 1 (ADIPOR1) and adiponectin receptor 2 (ADIPOR2) genes could contribute to the genetic risk for type 2 diabetes in a case-..
  14. Kaklamani V, Sadim M, Hsi A, Offit K, Oddoux C, Ostrer H, et al. Variants of the adiponectin and adiponectin receptor 1 genes and breast cancer risk. Cancer Res. 2008;68:3178-84 pubmed publisher
    ..To explore the association of genetic variants of the adiponectin (ADIPOQ) and adiponectin receptor 1 (ADIPOR1) genes with breast cancer risk, we conducted a case control study of female patients with breast cancer and ..
  15. Staiger H, Kaltenbach S, Staiger K, Stefan N, Fritsche A, Guirguis A, et al. Expression of adiponectin receptor mRNA in human skeletal muscle cells is related to in vivo parameters of glucose and lipid metabolism. Diabetes. 2004;53:2195-201 pubmed
    The adiponectin receptors, AdipoR1 and AdipoR2, are thought to transmit the insulin-sensitizing, anti-inflammatory, and atheroprotective effects of adiponectin...
  16. Damcott C, Ott S, Pollin T, Reinhart L, Wang J, O Connell J, et al. Genetic variation in adiponectin receptor 1 and adiponectin receptor 2 is associated with type 2 diabetes in the Old Order Amish. Diabetes. 2005;54:2245-50 pubmed
    Adiponectin receptor 1 (ADIPOR1) and adiponectin receptor 2 (ADIPOR2) are newly identified receptors for adiponectin, an adipocytokine with anti-inflammatory and insulin-sensitizing properties...
  17. Byeon J, Jeong J, Kim M, Lee S, Nam W, Myung S, et al. Adiponectin and adiponectin receptor in relation to colorectal cancer progression. Int J Cancer. 2010;127:2758-67 pubmed publisher
    ..Adiponectin is an adipokine that binds to 2 types of receptors, AdipoR1 and AdipoR2...
  18. Williams C, Mitsiades N, Sozopoulos E, Hsi A, Wolk A, Nifli A, et al. Adiponectin receptor expression is elevated in colorectal carcinomas but not in gastrointestinal stromal tumors. Endocr Relat Cancer. 2008;15:289-99 pubmed publisher
    ..Expression and localization of adiponectin receptors (AdipoR1 and AdipoR2) were assessed using immunohistochemistry...
  19. Wang H, Zhang H, Jia Y, Zhang Z, Craig R, Wang X, et al. Adiponectin receptor 1 gene (ADIPOR1) as a candidate for type 2 diabetes and insulin resistance. Diabetes. 2004;53:2132-6 pubmed
    ..Adiponectin acts by way of two receptors, ADIPOR1 and ADIPOR2...
  20. Kim J, Kim Y, Cho Y, Koo B, Lee E, Shin H, et al. Polymorphisms of ADIPOR1 and ADIPOR2 are associated with phenotypes of type 2 diabetes in Koreans. Clin Endocrinol (Oxf). 2009;70:66-74 pubmed publisher
    Adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2) are considered as candidate genes for type 2 diabetes because they mediate the metabolic effects of adiponectin on target tissues...
  21. Kantartzis K, Fritsche A, Machicao F, Haring H, Stefan N. The -8503 G/A polymorphism of the adiponectin receptor 1 gene is associated with insulin sensitivity dependent on adiposity. Diabetes Care. 2006;29:464 pubmed
  22. Loos R, Ruchat S, Rankinen T, Tremblay A, Perusse L, Bouchard C. Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Quebec Family Study. Am J Clin Nutr. 2007;85:26-34 pubmed
    ..We examined the effects of genetic variation in adiponectin (ADIPOQ) and adiponectin receptors 1 and 2 (ADIPOR1 and ADIPOR2) on resting metabolic rate, respiratory quotient (RQ), and adiposity-related phenotypes...
  23. He B, Pan Y, Zhang Y, Bao Q, Chen L, Nie Z, et al. Effects of genetic variations in the adiponectin pathway genes on the risk of colorectal cancer in the Chinese population. BMC Med Genet. 2011;12:94 pubmed publisher
    ..This study was designed to determine whether polymorphisms present in the ADIPOQ and its type 1 receptor (ADIPOR1) could affect the risk of CRC...
  24. Buechler C, Wanninger J, Neumeier M. Adiponectin receptor binding proteins--recent advances in elucidating adiponectin signalling pathways. FEBS Lett. 2010;584:4280-6 pubmed publisher
    ..Adiponectin binds to adiponectin receptors, AdipoR1 and AdipoR2, which are ubiquitously expressed...
  25. Dieudonne M, Bussiere M, Dos Santos E, Leneveu M, Giudicelli Y, Pecquery R. Adiponectin mediates antiproliferative and apoptotic responses in human MCF7 breast cancer cells. Biochem Biophys Res Commun. 2006;345:271-9 pubmed
    ..Moreover, adipose adiponectin production being strongly reduced in obesity, this study may help to explain why obesity is a risk factor of developing breast cancers. ..
  26. Crimmins N, Martin L. Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance. Obes Rev. 2007;8:419-23 pubmed
    ..genetic association studies have examined the role of polymorphisms in the adiponectin receptor 1 and 2 genes (ADIPOR1 and ADIPOR2) in insulin resistance and type 2 diabetes...
  27. Berner H, Lyngstadaas S, Spahr A, Monjo M, Thommesen L, Drevon C, et al. Adiponectin and its receptors are expressed in bone-forming cells. Bone. 2004;35:842-9 pubmed
    ..demonstrating transcription, translation, and secretion of adiponectin, as well as expression of its receptors, AdipoR1 and AdipoR2, in bone-forming cells...
  28. Soccio T, Zhang Y, Bacci S, Mlynarski W, Placha G, Raggio G, et al. Common haplotypes at the adiponectin receptor 1 (ADIPOR1) locus are associated with increased risk of coronary artery disease in type 2 diabetes. Diabetes. 2006;55:2763-70 pubmed
    ..This study investigated whether common polymorphisms in the adiponectin receptor 1 (ADIPOR1) gene mediating these effects influence the risk of coronary artery disease (CAD) in type 2 diabetes...
  29. Tan B, Chen J, Digby J, Keay S, Kennedy C, Randeva H. Upregulation of adiponectin receptor 1 and 2 mRNA and protein in adipose tissue and adipocytes in insulin-resistant women with polycystic ovary syndrome. Diabetologia. 2006;49:2723-8 pubmed
    ..is lower in IR states, exerts its glucose-lowering and anti-inflammatory effects by activating two receptors, ADIPOR1 and ADIPOR2. There are no data on the relative expression of these receptors in adipose tissue of PCOS women...
  30. Otani K, Kitayama J, Kamei T, Soma D, Miyato H, Yamauchi T, et al. Adiponectin receptors are downregulated in human gastric cancer. J Gastroenterol. 2010;45:918-27 pubmed publisher
    ..The purpose of this study was to quantitatively evaluate the expression of two adiponectin receptors, AdipoR1 and AdipoR2, in gastric cancer tissue...
  31. Cohen S, Gammon M, North K, Millikan R, Lange E, Williams S, et al. ADIPOQ, ADIPOR1, and ADIPOR2 polymorphisms in relation to serum adiponectin levels and BMI in black and white women. Obesity (Silver Spring). 2011;19:2053-62 pubmed publisher
    ..are highly heritable and several single-nucleotide polymorphisms (SNPs) in adiponectin-related genes (ADIPOQ, ADIPOR1, ADIPOR2) have been examined in relation to circulating adiponectin levels and obesity phenotypes, but despite ..
  32. Qi L, Doria A, Giorgi E, Hu F. Variations in adiponectin receptor genes and susceptibility to type 2 diabetes in women: a tagging-single nucleotide polymorphism haplotype analysis. Diabetes. 2007;56:1586-91 pubmed
    ..The metabolic effects of adiponectin are mediated by adiponectin receptors 1 (ADIPOR1) and 2 (ADIPOR2)...
  33. Siitonen N, Pulkkinen L, Mager U, Lindstrom J, Eriksson J, Valle T, et al. Association of sequence variations in the gene encoding adiponectin receptor 1 (ADIPOR1) with body size and insulin levels. The Finnish Diabetes Prevention Study. Diabetologia. 2006;49:1795-805 pubmed
    ..and anti-atherogenic effects on target tissues through two known receptors, adiponectin receptors 1 and 2 (ADIPOR1; ADIPOR2), which are encoded by the genes ADIPOR1 and ADIPOR2...
  34. Kitajima K, Miura S, Yamauchi T, Uehara Y, Kiya Y, Rye K, et al. Possibility of increasing cholesterol efflux by adiponectin and its receptors through the ATP binding cassette transporter A1 in HEK293T cells. Biochem Biophys Res Commun. 2011;411:305-11 pubmed publisher
    ..We transfected adiponectin receptor 1 and 2 (AdipoR1 and AdipoR2) cDNA into cells...
  35. Gialamas S, Petridou E, Tseleni Balafouta S, Spyridopoulos T, Matsoukis I, Kondi Pafiti A, et al. Serum adiponectin levels and tissue expression of adiponectin receptors are associated with risk, stage, and grade of colorectal cancer. Metabolism. 2011;60:1530-8 pubmed publisher
    ..05). Expression of both adiponectin receptors was stronger in adenocarcinoma vs normal tissue (P = .001). AdipoR1 expression was negatively associated with nodal stage (P = ...
  36. Abdul Ghafar J, Oh S, Park S, Wairagu P, Lee S, Jeong Y, et al. Expression of adiponectin receptor 1 is indicative of favorable prognosis in non-small cell lung carcinoma. Tohoku J Exp Med. 2013;229:153-62 pubmed
    ..Expression of immunohistochemically stained AdipoR1 and AdipoR2 was observed in all samples of non-neoplastic lung tissues...
  37. Rak A, Mellouk N, Froment P, Dupont J. Adiponectin and resistin: potential metabolic signals affecting hypothalamo-pituitary gonadal axis in females and males of different species. Reproduction. 2017;153:R215-R226 pubmed publisher
    ..Several studies have shown that these two hormones and the receptors for adiponectin, AdipoR1 and AdipoR2 are present in various reproductive tissues in both sexes of different species...
  38. Zhang Z, Li Y, Yang X, Wang L, Xu L, Zhang Q. Susceptibility of multiple polymorphisms in ADIPOQ, ADIPOR1 and ADIPOR2 genes to myocardial infarction in Han Chinese. Gene. 2018;658:10-17 pubmed publisher
    ..the association of 12 extensively studied polymorphisms in adiponectin (ADIPOQ), adiponectin receptor-1 (ADIPOR1) and adiponectin receptor-2 (ADIPOR2) genes with myocardial infarction in Han Chinese...
  39. Pierre P, Froment P, Negre D, Rame C, Barateau V, Chabrolle C, et al. Role of adiponectin receptors, AdipoR1 and AdipoR2, in the steroidogenesis of the human granulosa tumor cell line, KGN. Hum Reprod. 2009;24:2890-901 pubmed publisher
    ..We have previously shown that adiponectin receptors (AdipoR1 and AdipoR2) are expressed in human granulosa cells...
  40. Lee M, Klein R, El Shewy H, Luttrell D, Luttrell L. The adiponectin receptors AdipoR1 and AdipoR2 activate ERK1/2 through a Src/Ras-dependent pathway and stimulate cell growth. Biochemistry. 2008;47:11682-92 pubmed publisher
    ..Two adiponectin receptors, AdipoR1/R2, have been cloned, but relatively little is known about their intracellular signaling mechanisms...
  41. Sente T, Van Berendoncks A, Fransen E, Vrints C, Hoymans V. Tumor necrosis factor-? impairs adiponectin signalling, mitochondrial biogenesis, and myogenesis in primary human myotubes cultures. Am J Physiol Heart Circ Physiol. 2016;310:H1164-75 pubmed publisher
    ..We aimed to examine the impact of adiponectin receptor 1 (AdipoR1) deficiency and TNF-? treatment on adiponectin signaling, proliferative capacity, myogenic differentiation, and ..
  42. Nigro E, Matteis M, Roviezzo F, Mattera Iacono V, Scudiero O, Spaziano G, et al. Role of adiponectin in sphingosine-1-phosphate induced airway hyperresponsiveness and inflammation. Pharmacol Res. 2016;103:114-22 pubmed publisher
    ..Moreover, we observed a reduction of Adiponectin receptors (AdipoR1, AdipoR2 and T-cadherin) expression in S1P treated mice...
  43. Pacheco Pantoja E, Fraser W, Wilson P, Gallagher J. Differential effects of adiponectin in osteoblast-like cells. J Recept Signal Transduct Res. 2014;34:351-60 pubmed publisher
    ..We studied the presence of adiponectin receptors (AdipoR1, AdipoR2) and its direct effects in osteosarcoma cell line Saos-2...
  44. Salathia N, Shi J, Zhang J, Glynne R. An in vivo screen of secreted proteins identifies adiponectin as a regulator of murine cutaneous wound healing. J Invest Dermatol. 2013;133:812-821 pubmed publisher
    ..recent observations of a protective role of adiponectin in other tissue injury settings, suggest modulation of AdipoR1 for the clinical management of wounds, and demonstrate a new approach to the identification of regulators of a ..
  45. Song J, Choi S, Whitcomb D, Kim B. Adiponectin controls the apoptosis and the expression of tight junction proteins in brain endothelial cells through AdipoR1 under beta amyloid toxicity. Cell Death Dis. 2017;8:e3102 pubmed publisher
    ..We measured the expression of adiponectin receptors (AdipoR1 and AdipoR2) and the alteration of tight junction proteins in in vivo 5xFAD mouse brain...
  46. Jonsson J, Moschen A, Hickman I, Richardson M, Kaser S, Clouston A, et al. Adiponectin and its receptors in patients with chronic hepatitis C. J Hepatol. 2005;43:929-36 pubmed
    ..The hepatic mRNA expression of the adiponectin receptors, AdipoR1 and AdipoR2, displayed significant but opposite associations with phosphoenolpyruvate carboxykinase (PEPCK) gene ..
  47. Heiker J, Wottawah C, Juhl C, Kosel D, M rl K, Beck Sickinger A. Protein kinase CK2 interacts with adiponectin receptor 1 and participates in adiponectin signaling. Cell Signal. 2009;21:936-42 pubmed publisher
    ..glucose and lipid metabolism are mediated by two ubiquitously expressed seven-transmembrane receptors, AdipoR1 and -R2...
  48. Takeuchi S, Wada K, Uozumi Y, Otani N, Osada H, Nagatani K, et al. Adiponectin receptor 1 expression is associated with carotid plaque stability. Neurol India. 2013;61:249-53 pubmed publisher
    ..Enhancement of ADR1 expression could serve as a therapeutic target for the prevention of the formation of vulnerable plaque. ..
  49. Kim M, Maachi M, Debard C, Loizon E, Clement K, Bruckert E, et al. Increased adiponectin receptor-1 expression in adipose tissue of impaired glucose-tolerant obese subjects during weight loss. Eur J Endocrinol. 2006;155:161-5 pubmed
    To investigate the mRNA expression of adiponectin, AdipoR1 and AdipoR2, the two recently cloned adiponectin receptors and peroxisome proliferator activated receptor (PPAR)gamma2 in adipose tissue of obese individuals before and during a ..
  50. Nguyen P, GREENE E, Ishola P, Huff G, Donoghue A, Bottje W, et al. Chronic Mild Cold Conditioning Modulates the Expression of Hypothalamic Neuropeptide and Intermediary Metabolic-Related Genes and Improves Growth Performances in Young Chicks. PLoS ONE. 2015;10:e0142319 pubmed publisher
    ..Although their roles are still unknown in avian species, adiponectin (Adpn) and its related receptors (AdipoR1 and 2) were down regulated in the brain of CMCC compared to control chicks (P<0.05)...
  51. Punyadeera C, Zorenc A, Koopman R, McAinch A, Smit E, Manders R, et al. The effects of exercise and adipose tissue lipolysis on plasma adiponectin concentration and adiponectin receptor expression in human skeletal muscle. Eur J Endocrinol. 2005;152:427-36 pubmed
    ..Adiponectin is abundantly expressed in muscle, and, for the first time, it has been shown to be present in/on the sarcolemma of individual muscle fibres. ..
  52. van Stijn C, Kim J, Lusis A, Barish G, Tangirala R. Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response. FASEB J. 2015;29:636-49 pubmed publisher
    ..that exerts anti-inflammatory, antidiabetic, and antiatherogenic effects through its receptors (AdipoRs), AdipoR1 and AdipoR2, is an important therapeutic target...
  53. Almabouada F, Diaz Ruiz A, Rabanal Ruiz Y, Peinado J, Vazquez Martinez R, Malagon M. Adiponectin receptors form homomers and heteromers exhibiting distinct ligand binding and intracellular signaling properties. J Biol Chem. 2013;288:3112-25 pubmed publisher
    Adiponectin binds to two widely expressed receptors (AdipoR1 and AdipoR2) that contain seven transmembrane domains but, unlike G-protein coupled receptors, present an extracellular C terminus and a cytosolic N terminus...
  54. Emanuele E, Bertona M, Geroldi D. A multilocus candidate approach identifies ACE and HIF1A as susceptibility genes for cellulite. J Eur Acad Dermatol Venereol. 2010;24:930-5 pubmed publisher
  55. Ordelheide A, Heni M, Gommer N, Gasse L, Haas C, Guirguis A, et al. The myocyte expression of adiponectin receptors and PPAR? is highly coordinated and reflects lipid metabolism of the human donors. Exp Diabetes Res. 2011;2011:692536 pubmed publisher
    ..The mRNA levels of the three adiponectin receptors, AdipoR1, AdipoR2, and T-cadherin, were highly interrelated (r ? 0.91)...
  56. Richards J, Liu Z, Kawai T, Tabata K, Watanabe H, Suresh D, et al. Adiponectin and its receptors modulate granulosa cell and cumulus cell functions, fertility, and early embryo development in the mouse and human. Fertil Steril. 2012;98:471-9.e1 pubmed publisher
    ..Adiponectin differentially alters the expression of Adipor1/Adipor2 as well as genes related to steroidogenesis, ovulation, and apoptosis in cumulus cells versus granulosa ..
  57. Mora García G, Ruiz Díaz M, Espitia Almeida F, Gómez Camargo D. Variations in ADIPOR1 But Not ADIPOR2 are Associated With Hypertriglyceridemia and Diabetes in an Admixed Latin American Population. Rev Diabet Stud. 2017;14:311-328 pubmed publisher
    ..Its activity is mainly mediated by the transmembrane receptors AdipoR1 and AdipoR2, which are encoded by ADIPOR1 (1q32.1) and ADIPOR2 (12p13.33) genes, respectively...
  58. Ding Q, Wang Z, Chen Y. Endocytosis of adiponectin receptor 1 through a clathrin- and Rab5-dependent pathway. Cell Res. 2009;19:317-27 pubmed publisher
    ..Here, we analyzed the endocytosis of adiponectin and adiponectin receptor 1 (AdipoR1) and found that they are both internalized into transferrin-positive compartments that follow similar traffic ..
  59. Wilk S, Scheibenbogen C, Bauer S, Jenke A, Rother M, Guerreiro M, et al. Adiponectin is a negative regulator of antigen-activated T cells. Eur J Immunol. 2011;41:2323-32 pubmed publisher
    ..After stimulation, the expression of adiponectin receptor 1 (AdipoR1) and AdipoR2 was upregulated on the surface of antigen-specific T cells, as determined by tetramer or CD137 ..
  60. Gao Q, Zheng J, Yao X, Peng B. Adiponectin inhibits VEGF-A in prostate cancer cells. Tumour Biol. 2015;36:4287-92 pubmed publisher
    ..adiponectin levels in prostate cancer patients, but also showed significant decreases in adiponectin receptor I (AdipoR1) levels in the resected prostate cancer specimen...
  61. Xu Y, Zhang C, Wang N, Ling F, Li P, Gao Y, et al. Adiponectin inhibits lymphotoxin-? receptor-mediated NF-?B signaling in human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2011;404:1060-4 pubmed publisher
    Adiponectin exerts anti-diabetic and anti-atherogenesis properties through its 2 receptors (AdipoR1 and AdipoR2). However, the signaling pathways responsible for the anti-inflammatory effects of adiponectin are largely unknown...
  62. Liu X, Chen J, Zhang J. AdipoR1-mediated miR-3908 inhibits glioblastoma tumorigenicity through downregulation of STAT2 associated with the AMPK/SIRT1 pathway. Oncol Rep. 2017;37:3387-3396 pubmed publisher
    ..In the present study, whether the expression of STAT2, AdipoR1/AMPK/SIRT1 pathway of glioma is regulated by miR-3908 was explored...
  63. Tong K, Chen C, Huang K, Shieh D, Cheng H, Tzeng C, et al. Adiponectin increases MMP-3 expression in human chondrocytes through AdipoR1 signaling pathway. J Cell Biochem. 2011;112:1431-40 pubmed publisher
    ..Adiponectin-mediated MMP-3 expression was attenuated by AdipoR1 but not AdipoR2 siRNA...
  64. Kleinmann N, Duivenvoorden W, Hopmans S, Beatty L, Qiao S, Gallino D, et al. Underactivation of the adiponectin-adiponectin receptor 1 axis in clear cell renal cell carcinoma: implications for progression. Clin Exp Metastasis. 2014;31:169-83 pubmed publisher
    ..We investigated the adiponectin signaling pathway in RCC, focusing on adiponectin receptor 1 (AdipoR1) and associated activation of AMPK...
  65. Potapov V, Chistiakov D, Dubinina A, Shamkhalova M, Shestakova M, Nosikov V. Adiponectin and adiponectin receptor gene variants in relation to type 2 diabetes and insulin resistance-related phenotypes. Rev Diabet Stud. 2008;5:28-37 pubmed publisher
    ..Genetic variations in adiponectin (ADIPOQ) and adiponectin 1 and 2 receptor (ADIPOR1 and ADIPOR2) could have effects on IR-related phenotypes and T2D...
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    ..We identified adiponectin receptor 1 (ADIPOR1), a receptor for the adipocytokine adiponectin, as a direct target of miR-221/222...
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    Shared genetic variants in ADIPOR1 have been identified as closely related to coronary artery disease (CAD), type 2 diabetes (T2D), and T2D with CAD susceptibility, suggesting that these variants are strong candidates for the common soil ..
  68. Felder T, Hahne P, Soyal S, Miller K, Höffinger H, Oberkofler H, et al. Hepatic adiponectin receptors (ADIPOR) 1 and 2 mRNA and their relation to insulin resistance in obese humans. Int J Obes (Lond). 2010;34:846-51 pubmed publisher
    ..receptor (ADIPOR)1 and ADIPOR2 are critical components in the adiponectin signalling cascade, we studied hepatic ADIPOR1/2 mRNA levels in humans and their relation to IR...
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    Adiponectin receptor-1 (AdipoR1) expression in skeletal muscle has been suggested to play an important role in insulin resistance and diabetes...
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    ..It seems to be very important to study the expression of adiponectin receptor 1 (AdipoR1) and receptor 2 (AdipoR2) in the human breast epithelial cells and breast cancer cells in order to clarify ..