adiponectin

Summary

Gene Symbol: adiponectin
Description: adiponectin, C1Q and collagen domain containing
Alias: ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28, adiponectin, 30 kDa adipocyte complement-related protein, adipocyte complement-related 30 kDa protein, adipose most abundant gene transcript 1 protein, adipose specific collagen-like factor, gelatin-binding protein 28
Species: human
Products:     adiponectin

Top Publications

  1. Kukla M, Mazur W, Bułdak R, Zwirska Korczala K. Potential role of leptin, adiponectin and three novel adipokines--visfatin, chemerin and vaspin--in chronic hepatitis. Mol Med. 2011;17:1397-410 pubmed publisher
    ..On the other hand, it inhibits synthesis of proinflammatory mediators and enhances adiponectin production, influences adipocyte differentiation and maturation and regulates glucose uptake in adipocytes...
  2. Dastani Z, Hivert M, Timpson N, Perry J, Yuan X, Scott R, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 2012;8:e1002607 pubmed publisher
    Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits...
  3. Poehls J, Wassel C, Harris T, Havel P, Swarbrick M, Cummings S, et al. Association of adiponectin with mortality in older adults: the Health, Aging, and Body Composition Study. Diabetologia. 2009;52:591-5 pubmed publisher
    Despite inverse associations with insulin resistance and adiposity, adiponectin has been associated with both increased and decreased risk of cardiovascular disease...
  4. Tsubakio Yamamoto K, Matsuura F, Koseki M, Oku H, Sandoval J, Inagaki M, et al. Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages. Biochem Biophys Res Commun. 2008;375:390-4 pubmed publisher
    ..b>Adiponectin (APN) secreted from adipocytes is one of the important molecules to inhibit the development of atherosclerosis...
  5. Pérez Martínez P, López Miranda J, Cruz Teno C, Delgado Lista J, Jiménez Gómez Y, Fernández J, et al. Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men. J Nutr. 2008;138:1609-14 pubmed
    b>Adiponectin (adipoQ) gene variants have been associated with type 2 diabetes mellitus and insulin resistance...
  6. Margaritis M, Antonopoulos A, Digby J, Lee R, Reilly S, Coutinho P, et al. Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels. Circulation. 2013;127:2209-21 pubmed publisher
    b>Adiponectin is an adipokine with potentially important roles in human cardiovascular disease states. We studied the role of adiponectin in the cross-talk between adipose tissue and vascular redox state in patients with atherosclerosis...
  7. Windham B, Griswold M, Farasat S, Ling S, Carlson O, Egan J, et al. Influence of leptin, adiponectin, and resistin on the association between abdominal adiposity and arterial stiffness. Am J Hypertens. 2010;23:501-7 pubmed publisher
    ..adipokine production, the objectives of this study were to examine the influence of adipokines such as leptin, adiponectin, and resistin on the relationship between abdominal adiposity and arterial stiffness...
  8. Napoli N, Pedone C, Pozzilli P, Lauretani F, Ferrucci L, Incalzi R. Adiponectin and bone mass density: The InCHIANTI study. Bone. 2010;47:1001-5 pubmed publisher
    b>Adiponectin serum concentration has been reported to be inversely correlated with bone mineral density (BMD) in humans. The data on this issue, however, are biased by small study sample size and lack of controlling for body composition...
  9. Mazaki Tovi S, Romero R, Vaisbuch E, Erez O, Mittal P, Chaiworapongsa T, et al. Maternal serum adiponectin multimers in gestational diabetes. J Perinat Med. 2009;37:637-50 pubmed publisher
    b>Adiponectin, an adipokine with profound insulin-sensitizing effect, consists of heterogeneous species of multimers...

More Information

Publications382 found, 100 shown here

  1. Tian L, Luo N, Klein R, Chung B, Garvey W, Fu Y. Adiponectin reduces lipid accumulation in macrophage foam cells. Atherosclerosis. 2009;202:152-61 pubmed publisher
    b>Adiponectin is one of several, important metabolically active cytokines secreted from adipocytes...
  2. Sabouri S, Ghayour Mobarhan M, Moohebati M, Hassani M, Kassaeian J, Tatari F, et al. Association between 45T/G polymorphism of adiponectin gene and coronary artery disease in an Iranian population. ScientificWorldJournal. 2011;11:93-101 pubmed publisher
    A single nucleotide polymorphism (SNP) in the adiponectin gene, 45T/G, has been reported in relation to a number of metabolic disorders, including obesity, insulin resistance, and diabetes...
  3. Tabatabaei Malazy O, Hasani Ranjbar S, Amoli M, Heshmat R, Sajadi M, Derakhshan R, et al. Gender-specific differences in the association of adiponectin gene polymorphisms with body mass index. Rev Diabet Stud. 2010;7:241-6 pubmed publisher
    b>Adiponectin gene polymorphisms are associated with obesity, metabolic syndrome and type 2 diabetes (T2D)...
  4. Wassel C, Pankow J, Rasmussen Torvik L, Li N, Taylor K, Guo X, et al. Associations of SNPs in ADIPOQ and subclinical cardiovascular disease in the multi-ethnic study of atherosclerosis (MESA). Obesity (Silver Spring). 2011;19:840-7 pubmed publisher
    Circulating adiponectin is associated with both clinical and subclinical cardiovascular disease (CVD)...
  5. Dastani Z, Johnson T, Kronenberg F, Nelson C, Assimes T, März W, et al. The shared allelic architecture of adiponectin levels and coronary artery disease. Atherosclerosis. 2013;229:145-8 pubmed publisher
    ..Low adiponectin levels, a hormone secreted only from adipocytes, have been associated with an increased risk of CAD in ..
  6. Youn J, Kim C, Park S, Lee S, Kang S, Choi D, et al. Adiponectin and progression of arterial stiffness in hypertensive patients. Int J Cardiol. 2013;163:316-319 pubmed publisher
    ..We hypothesized that in hypertensive patients, initial levels of adipokines such as adiponectin and resistin are related to the progression of arterial stiffness, which has been proven to be associated with ..
  7. Matharoo K, Arora P, Bhanwer A. Association of adiponectin (AdipoQ) and sulphonylurea receptor (ABCC8) gene polymorphisms with Type 2 Diabetes in North Indian population of Punjab. Gene. 2013;527:228-34 pubmed publisher
    In Type 2 Diabetes (T2D), adiponectin (AdipoQ) and sulphonylurea receptor genes (ABCC8) are important targets for candidate gene association studies...
  8. Koskinen A, Juslin S, Nieminen R, Moilanen T, Vuolteenaho K, Moilanen E. Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways. Arthritis Res Ther. 2011;13:R184 pubmed publisher
    b>Adiponectin is an adipokine that regulates energy metabolism and insulin sensitivity, but recent studies have pointed also to a role in inflammation and arthritis...
  9. Mills K, Hamm L, Alper A, Miller C, Hudaihed A, Balamuthusamy S, et al. Circulating adipocytokines and chronic kidney disease. PLoS ONE. 2013;8:e76902 pubmed publisher
    ..We investigated the association of plasma leptin, resistin and adiponectin with CKD in 201 patients with CKD and 201 controls without...
  10. Vetvik K, Sonerud T, Lindeberg M, Lüders T, Størkson R, Jonsdottir K, et al. Globular adiponectin and its downstream target genes are up-regulated locally in human colorectal tumors: ex vivo and in vitro studies. Metabolism. 2014;63:672-81 pubmed publisher
    Low plasma adiponectin levels are linked to obesity, insulin resistance, and the risk of several types of malignancy...
  11. Donoso M, Muñoz Calvo M, Barrios V, Martinez G, Hawkins F, Argente J. Increased leptin/adiponectin ratio and free leptin index are markers of insulin resistance in obese girls during pubertal development. Horm Res Paediatr. 2013;80:363-70 pubmed publisher
    ..We hypothesized that the leptin/adiponectin (L/A) ratio and free leptin index (FLI) are good markers of insulin resistance (IR) and total body fat (TBF) ..
  12. Sulistyoningrum D, Gasevic D, Lear S, Ho J, Mente A, Devlin A. Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study. Cardiovasc Diabetol. 2013;12:170 pubmed publisher
    ..b>Adiponectin is an insulin sensitizing adipocytokine that circulates as multiple isoforms, with high molecular weight (HMW) ..
  13. Ye E, Yang H, Chen L, Chen Q, Sun M, Lin Z, et al. Adiponectin and peroxisome proliferator-activated receptor-? gene polymorphisms and gene-gene interactions with type 2 diabetes. Life Sci. 2014;98:55-9 pubmed publisher
    To investigate whether gene polymorphisms of both adiponectin and peroxisome proliferator-activated receptor gamma (PPAR?) influence type 2 diabetes mellitus (T2DM) respectively in the Han people of the Wenzhou region of China and ..
  14. Ahasic A, Zhao Y, Su L, Sheu C, Thompson B, Christiani D. Adiponectin gene polymorphisms and acute respiratory distress syndrome susceptibility and mortality. PLoS ONE. 2014;9:e89170 pubmed publisher
    b>Adiponectin is an anti-inflammatory adipokine that is the most abundant gene product of adipose tissue. Lower levels have been observed in obesity, insulin resistance, and in critical illness...
  15. Kim J, Ahn S, Yoon J, Koh S, Yoon J, Yoo B, et al. Prospective study of serum adiponectin and incident metabolic syndrome: the ARIRANG study. Diabetes Care. 2013;36:1547-53 pubmed publisher
    Increased adiponectin levels may play a protective role in the development of metabolic abnormalities, but prospective studies of the predictive value of serum adiponectin to identify individuals at high risk of new-onset metabolic ..
  16. Qiao L, MacLean P, Schaack J, Orlicky D, Darimont C, Pagliassotti M, et al. C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer. Diabetes. 2005;54:1744-54 pubmed
    b>Adiponectin is an adipose-derived hormone that enhances insulin sensitivity and plays an important role in regulating energy homeostasis...
  17. Escobar Morreale H, Villuendas G, Botella Carretero J, Alvarez Blasco F, Sanchón R, Luque Ramirez M, et al. Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study. Hum Reprod. 2006;21:2257-65 pubmed
    We conducted a cross-sectional case-control study to evaluate the possible involvement of adiponectin and resistin in the pathogenesis of polycystic ovary syndrome (PCOS)...
  18. Considine R, Premkumar A, Reynolds J, Sebring N, Ricks M, Sumner A. Adiponectin and leptin in African Americans. Obesity (Silver Spring). 2008;16:428-34 pubmed publisher
    African Americans (AAs) have less visceral and more subcutaneous fat than whites, thus the relationship of adiponectin and leptin to body fat and insulin sensitivity in AA may be different from that in whites...
  19. Frommer K, Zimmermann B, Meier F, Schröder D, Heil M, Schaffler A, et al. Adiponectin-mediated changes in effector cells involved in the pathophysiology of rheumatoid arthritis. Arthritis Rheum. 2010;62:2886-99 pubmed publisher
    ..key players in the pathophysiology of RA, this study was undertaken to analyze the effects of the key adipokine adiponectin on proinflammatory and prodestructive synovial effector cells...
  20. Cieslak J, Skorczyk A, Stachowiak M, Szydlowski M, Grzes M, Paczynska P, et al. Polymorphisms in 5'-flanking regions of genes encoding adiponectin, leptin, and resistin are not associated with obesity of Polish children and adolescents. Mol Biol Rep. 2011;38:1793-8 pubmed publisher
    ..In this study we screened for polymorphism 5'-flanking regions of the adiponectin (ADIPOQ), leptin (LEP) and resistin (RETN) genes in a cohort of Polish obese children and adolescents (n = 243) ..
  21. Arita Y, Kihara S, Ouchi N, Maeda K, Kuriyama H, Okamoto Y, et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation. 2002;105:2893-8 pubmed
    ..We previously reported that adiponectin, an adipocyte-specific plasma protein, accumulated in the human injured artery and suppressed endothelial ..
  22. Ding M, Xie Y, Wagner R, Jin Y, Carrao A, Liu L, et al. Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4. Arterioscler Thromb Vasc Biol. 2011;31:1403-10 pubmed publisher
    The adipocyte-secreted hormone adiponectin exerts important cardioprotective and antidiabetic effects. Little is known about its effect on vascular smooth muscle cells (VSMC), key cells in restenosis, hypertension, and atherosclerosis...
  23. Piñeiro R, Iglesias M, Gallego R, Raghay K, Eiras S, Rubio J, et al. Adiponectin is synthesized and secreted by human and murine cardiomyocytes. FEBS Lett. 2005;579:5163-9 pubmed
    b>Adiponectin is thought to play a decisive role in the relationships among obesity, insulin resistance and cardiovascular risk...
  24. Ozkurt B, Ozkurt Z, Altay M, Aktekin C, Caglayan O, Tabak Y. The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. Eklem Hastalik Cerrahisi. 2009;20:78-84 pubmed
    The aim of the present study was to evaluate the possible correlation between bone mass and serum adiponectin levels, and the correlation between adiponectin levels and osteoporotic fracture risk in a prospective clinical trial...
  25. Ruchat S, Loos R, Rankinen T, Vohl M, Weisnagel S, Despres J, et al. Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study. Diabet Med. 2008;25:400-6 pubmed publisher
    Studies suggest that adiponectin (APM1) and its receptors 1 and 2 (AdipoR1 and AdipoR2) play an important role in the development of insulin resistance (IR)...
  26. Gonullu G, Kahraman H, Bedir A, Bektas A, Yucel I. Association between adiponectin, resistin, insulin resistance, and colorectal tumors. Int J Colorectal Dis. 2010;25:205-12 pubmed publisher
    In this study, we have examined the correlation between colorectal cancer (CRC) and serum adiponectin and resistin levels, body mass index and insulin resistance...
  27. Saraheimo M, Forsblom C, Fagerudd J, Teppo A, Pettersson Fernholm K, Frystyk J, et al. Serum adiponectin is increased in type 1 diabetic patients with nephropathy. Diabetes Care. 2005;28:1410-4 pubmed
    To elucidate whether serum adiponectin is associated with renal function, low-grade inflammatory markers, metabolic control, and insulin resistance in type 1 diabetic patients with and without nephropathy...
  28. Yang W, Yang Y, Chen C, Wu I, Lu J, Lu F, et al. Adiponectin SNP276 is associated with obesity, the metabolic syndrome, and diabetes in the elderly. Am J Clin Nutr. 2007;86:509-13 pubmed
    Genetic variations of the human adiponectin gene are associated with metabolic phenotypes, including obesity, insulin sensitivity, and diabetes. However, these associations have not been examined in an elderly population...
  29. Li L, Kang X, Ran X, Wang Y, Wang C, Huang L, et al. Associations between 45T/G polymorphism of the adiponectin gene and plasma adiponectin levels with type 2 diabetes. Clin Exp Pharmacol Physiol. 2007;34:1287-90 pubmed
    ..study was to investigate the association between the single nucleotide polymorphism (SNP) 45T/G and plasma adiponectin levels and the prevalence of Type 2 diabetes mellitus (T2DM) in Uygurs of the Xinjiang region, China. 2...
  30. Phillips S, Kung J, Ciaraldi T, Choe C, Christiansen L, Mudaliar S, et al. Selective regulation of cellular and secreted multimeric adiponectin by antidiabetic therapies in humans. Am J Physiol Endocrinol Metab. 2009;297:E767-73 pubmed publisher
    b>Adiponectin, an insulin-sensitizing factor secreted from adipose tissue, is decreased in individuals with type 2 diabetes (T2D) and increased in response to thiazolidinedione (TZD) therapy...
  31. Al Daghri N, Al Attas O, Alokail M, Alkharfy K, Hussain T, Yakout S, et al. Adiponectin gene polymorphisms (T45G and G276T), adiponectin levels and risk for metabolic diseases in an Arab population. Gene. 2012;493:142-7 pubmed publisher
    In this study we examined the association of adiponectin gene variants with circulating adiponectin, and known metabolic diseases in 298 healthy controls and 297 Saudi subjects with type 2 diabetes mellitus (T2DM)...
  32. Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, et al. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem. 2004;279:1304-9 pubmed
    b>Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic properties. Here, we investigated whether adiponectin regulates angiogenic processes in vitro and in vivo...
  33. Okamoto Y, Arita Y, Nishida M, Muraguchi M, Ouchi N, Takahashi M, et al. An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm Metab Res. 2000;32:47-50 pubmed
    ..gene product possesses significant homology to collagens VIII, X and complement factor C1q, and we named it adiponectin. In the current study, we analyzed characteristics of adiponectin in vitro and in vivo...
  34. Lee Y, Lee N, Cho Y, Moon M, Jung H, Park Y, et al. Genetic association study of adiponectin polymorphisms with risk of Type 2 diabetes mellitus in Korean population. Diabet Med. 2005;22:569-75 pubmed
    ..any association between Type 2 diabetes mellitus and two single nucleotide polymorphisms (SNPs) in the adiponectin gene, T45G and G276T, in the Korean population...
  35. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 2002;8:1288-95 pubmed
    b>Adiponectin (Ad) is a hormone secreted by adipocytes that regulates energy homeostasis and glucose and lipid metabolism. However, the signaling pathways that mediate the metabolic effects of Ad remain poorly identified...
  36. Engeli S, Feldpausch M, Gorzelniak K, Hartwig F, Heintze U, Janke J, et al. Association between adiponectin and mediators of inflammation in obese women. Diabetes. 2003;52:942-7 pubmed
    Low plasma levels of the anti-inflammatory factor adiponectin characterize obesity and insulin resistance...
  37. Otsuka F, Sugiyama S, Kojima S, Maruyoshi H, Funahashi T, Sakamoto T, et al. Hypoadiponectinemia is associated with impaired glucose tolerance and coronary artery disease in non-diabetic men. Circ J. 2007;71:1703-9 pubmed
    ..An anti-atherogenic adipocytokine, adiponectin, is decreased in type 2 diabetes mellitus, but its role in non-diabetic subjects has not been clarified...
  38. Yang M, Qiu C, Chen W, Xu L, Yu M, Xiang H. Identification of a regulatory single nucleotide polymorphism in the adiponectin (APM1) gene associated with type 2 diabetes in Han nationality. Biomed Environ Sci. 2008;21:454-9 pubmed publisher
    To identify the genetic defects of the the adiponectin (APM1) gene that contribute to the development of type 2 diabetes (T2DM) and determine the functional single nucleotide polymorphisms (SNPs) in the APM1 gene associated with T2DM in ..
  39. Bouatia Naji N, Meyre D, Lobbens S, Séron K, Fumeron F, Balkau B, et al. ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes. 2006;55:545-50 pubmed
    Common single nucleotide polymorphisms (SNPs) in the ACDC adiponectin encoding gene have been associated with insulin resistance and type 2 diabetes in several populations...
  40. Vionnet N, Tregouet D, Kazeem G, Gut I, Groop P, Tarnow L, et al. Analysis of 14 candidate genes for diabetic nephropathy on chromosome 3q in European populations: strongest evidence for association with a variant in the promoter region of the adiponectin gene. Diabetes. 2006;55:3166-74 pubmed
    ..Polymorphisms in three genes, glucose transporter 2 (SLC2A2), kininogen (KNG1), and adiponectin (ADIPOQ), showed nominal association with diabetic nephropathy in single-point analysis...
  41. Shen Y, Hughes J, Charlesworth J, Kelly J, Peake P. Adiponectin is present in the urine in its native conformation, and specifically reduces the secretion of MCP-1 by proximal tubular cells. Nephrology (Carlton). 2008;13:405-10 pubmed publisher
    To determine whether adiponectin detected in urine is present in its native form and if adiponectin receptors (AdipoR) present and functional in proximal tubular (HK-2) cells...
  42. Sharma K, Ramachandrarao S, Qiu G, Usui H, Zhu Y, Dunn S, et al. Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest. 2008;118:1645-56 pubmed publisher
    ..However, the link between early albuminuria and adiposity remains unclear. To determine whether adiponectin, an adipocyte-derived hormone, is a communication signal between adipocytes and the kidney, we performed ..
  43. Basurto L, Galvan R, Cordova N, Saucedo R, Vargas C, Campos S, et al. Adiponectin is associated with low bone mineral density in elderly men. Eur J Endocrinol. 2009;160:289-93 pubmed publisher
    Recent evidence suggests that adiponectin may play a role in bone metabolism. Previous studies demonstrated that the adiponectin levels had a negative correlation with bone mineral density (BMD) in women...
  44. Tsou P, Jiang Y, Chang C, Wei J, Sung F, Lin C, et al. Sex-related differences between adiponectin and insulin resistance in schoolchildren. Diabetes Care. 2004;27:308-13 pubmed
    To study the effect of body composition and adiponectin on insulin resistance and beta-cell function in schoolchildren during puberty...
  45. Fumeron F, Aubert R, Siddiq A, Betoulle D, Péan F, Hadjadj S, et al. Adiponectin gene polymorphisms and adiponectin levels are independently associated with the development of hyperglycemia during a 3-year period: the epidemiologic data on the insulin resistance syndrome prospective study. Diabetes. 2004;53:1150-7 pubmed
    The plasma concentration of the adipocyte-derived peptide adiponectin is decreased in patients with obesity and type 2 diabetes. The adiponectin gene is located on chromosome 3q27, where a diabetes susceptibility locus has been mapped...
  46. Hegener H, Lee I, Cook N, Ridker P, Zee R. Association of adiponectin gene variations with risk of incident myocardial infarction and ischemic stroke: a nested case-control study. Clin Chem. 2006;52:2021-7 pubmed
    b>Adiponectin (ADIPOQ) gene variations are associated with risk of cardiovascular disease in patients with diabetes...
  47. Okamoto Y, Folco E, Minami M, Wara A, Feinberg M, Sukhova G, et al. Adiponectin inhibits the production of CXC receptor 3 chemokine ligands in macrophages and reduces T-lymphocyte recruitment in atherogenesis. Circ Res. 2008;102:218-25 pubmed
    Obese individuals often have low plasma adiponectin and concomitant chronic inflammation with a predisposition to metabolic and cardiovascular diseases...
  48. Chiodini B, Specchia C, Gori F, Barlera S, D Orazio A, Pietri S, et al. Adiponectin gene polymorphisms and their effect on the risk of myocardial infarction and type 2 diabetes: an association study in an Italian population. Ther Adv Cardiovasc Dis. 2010;4:223-30 pubmed publisher
    While many studies have shown an association between the gene coding for adiponectin (ADIPOQ) and adiponectin levels, much more controversy surrounds its association with metabolic traits such as insulin resistance, obesity and type 2 ..
  49. Hirata A, Kishida K, Nakatsuji H, Kobayashi H, Funahashi T, Shimomura I. High serum C1q-adiponectin/total adiponectin ratio correlates with coronary artery disease in Japanese type 2 diabetics. Metabolism. 2013;62:578-85 pubmed publisher
    b>Adiponectin, an adipocyte-derived protein, has potential antiatherogenic properties. Low levels of serum total-adiponectin (Total-APN) correlate with diabetes and coronary artery disease (CAD)...
  50. Vasseur F, Helbecque N, Lobbens S, Vasseur Delannoy V, Dina C, Clement K, et al. Hypoadiponectinaemia and high risk of type 2 diabetes are associated with adiponectin-encoding (ACDC) gene promoter variants in morbid obesity: evidence for a role of ACDC in diabesity. Diabetologia. 2005;48:892-9 pubmed
    ..We genotyped known single nucleotide polymorphisms (SNPs) in the adiponectin-encoding adipocyte C1q and collagen-domain-containing (ACDC) gene (-11,391G>A, -11,377C>G, +45T>G and +..
  51. Gable D, Matin J, Whittall R, Cakmak H, Li K, Cooper J, et al. Common adiponectin gene variants show different effects on risk of cardiovascular disease and type 2 diabetes in European subjects. Ann Hum Genet. 2007;71:453-66 pubmed
    ..These conditions have been associated with variation in the adiponectin gene, although evidence for this relationship has been variable, with differences found even in similar samples...
  52. Sun H, Gong Z, Yin J, Liu H, Liu Y, Guo Z, et al. The association of adiponectin allele 45T/G and -11377C/G polymorphisms with Type 2 diabetes and rosiglitazone response in Chinese patients. Br J Clin Pharmacol. 2008;65:917-26 pubmed publisher
    Rosiglitazone is able to increase serum adiponectin levels significantly in Type 2 diabetic patients...
  53. Stumvoll M, Tschritter O, Fritsche A, Staiger H, Renn W, Weisser M, et al. Association of the T-G polymorphism in adiponectin (exon 2) with obesity and insulin sensitivity: interaction with family history of type 2 diabetes. Diabetes. 2002;51:37-41 pubmed
    The adipocyte-derived hormone adiponectin seems to protect from insulin resistance, a key factor in the pathogenesis of type 2 diabetes...
  54. Ouchi N, Ohishi M, Kihara S, Funahashi T, Nakamura T, Nagaretani H, et al. Association of hypoadiponectinemia with impaired vasoreactivity. Hypertension. 2003;42:231-4 pubmed
    Endothelial dysfunction is a crucial feature in the evolution of atherosclerosis. Adiponectin is an adipocyte-specific plasma protein with antiatherogenic and antidiabetic properties...
  55. Katsiougiannis S, Kapsogeorgou E, Manoussakis M, Skopouli F. Salivary gland epithelial cells: a new source of the immunoregulatory hormone adiponectin. Arthritis Rheum. 2006;54:2295-9 pubmed
    b>Adiponectin is an adipocytokine that displays insulin-sensitizing and immunoregulatory properties...
  56. Altinova A, Toruner F, Bozkurt N, Bukan N, Karakoc A, Yetkin I, et al. Circulating concentrations of adiponectin and tumor necrosis factor-alpha in gestational diabetes mellitus. Gynecol Endocrinol. 2007;23:161-5 pubmed
    b>Adiponectin and tumor necrosis factor-alpha (TNF-alpha) have been implicated in insulin resistance and diabetes mellitus (DM)...
  57. Hwang J, Yang W, Chiang F, Chen M, Lin H, Huang P, et al. Association of circulating matrix metalloproteinase-1, but not adiponectin, with advanced coronary artery disease. Atherosclerosis. 2009;204:293-7 pubmed publisher
    Recent evidence suggests that high tissue matrix metalloproteinase-1 (MMP-1) and low adiponectin may serve as biomarkers of atherosclerosis. Results on the associations of circulating MMP-1 and adiponectin concentrations are scarce...
  58. Suriyaprom K, Phonrat B, Namjuntra P, Harnroongroj T, Tungtrongchitr R. The -11377C > G adiponectin gene polymorphism alters the adiponectin concentration and the susceptibility to type 2 diabetes in Thais. Int J Vitam Nutr Res. 2010;80:216-24 pubmed publisher
    The aims of this study were first to detect the levels of adiponectin, insulin, albumin, glucose, alanine aminotransferase (ALT), lipids, homeostasis model assessment for insulin resistance (HOMA-IR), and anthropometric variables in type ..
  59. Cauchi S, Nead K, Choquet H, Horber F, Potoczna N, Balkau B, et al. The genetic susceptibility to type 2 diabetes may be modulated by obesity status: implications for association studies. BMC Med Genet. 2008;9:45 pubmed publisher
  60. Ouchi N, Kihara S, Arita Y, Nishida M, Matsuyama A, Okamoto Y, et al. Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation. 2001;103:1057-63 pubmed
    ..Recently, we discovered an adipocyte-specific plasma protein, adiponectin, that is decreased in patients with coronary artery disease...
  61. Yatagai T, Nishida Y, Nagasaka S, Nakamura T, Tokuyama K, Shindo M, et al. Relationship between exercise training-induced increase in insulin sensitivity and adiponectinemia in healthy men. Endocr J. 2003;50:233-8 pubmed
    Circulating concentrations of adiponectin, an adipocyte-derived protein, are increased by thiazolidinediones and by weight reduction, accompanied with improvement in insulin sensitivity...
  62. Tejero M, Cai G, Göring H, Diego V, Cole S, Bacino C, et al. Linkage analysis of circulating levels of adiponectin in Hispanic children. Int J Obes (Lond). 2007;31:535-42 pubmed
    b>Adiponectin, a hormone produced exclusively by adipose tissue, is inversely associated with insulin resistance and proinflammatory conditions...
  63. Du J, Ye X, Li Q, Yu X, Cheng J, Ma J, et al. Genetic variants in the ADIPOQ gene and the risk of metabolic syndrome: a case-control study of a Chinese Han population. Ann Hum Genet. 2012;76:101-9 pubmed
    ..Genotypes of MetS patients (n=1049) and normal controls (n= 1092) were analysed by TaqMan® assay, and serum adiponectin concentration was measured by ELISA...
  64. Wang Q, Yang L, Li X, Xie H, Liao E, Wang M, et al. Effects of 17?-estradiol on adiponectin regulation of the expression of osteoprotegerin and receptor activator of nuclear factor-?B ligand. Bone. 2012;51:515-23 pubmed publisher
    b>Adiponectin may exert a negative effect on bone metabolism by regulating osteoprotegerin (OPG) and receptor activator of nuclear factor-?B ligand (RANKL) expression...
  65. Chan K, Lam K, Cheng O, Kwan J, Ho P, Cheng K, et al. Adiponectin is protective against oxidative stress induced cytotoxicity in amyloid-beta neurotoxicity. PLoS ONE. 2012;7:e52354 pubmed publisher
    ..We studied the potential protective effect of adiponectin (an adipokine with insulin-sensitizing, anti-inflammatory and anti-oxidant properties) against A? neurotoxicity ..
  66. Folco E, Rocha V, Lopez Ilasaca M, Libby P. Adiponectin inhibits pro-inflammatory signaling in human macrophages independent of interleukin-10. J Biol Chem. 2009;284:25569-75 pubmed publisher
    ..b>Adiponectin, a vasculoprotective molecule with insulin-sensitizing and anti-atherogenic properties, suppresses pro-..
  67. Peters K, Beilby J, Cadby G, Warrington N, Bruce D, Davis W, et al. A comprehensive investigation of variants in genes encoding adiponectin (ADIPOQ) and its receptors (ADIPOR1/R2), and their association with serum adiponectin, type 2 diabetes, insulin resistance and the metabolic syndrome. BMC Med Genet. 2013;14:15 pubmed publisher
    Low levels of serum adiponectin have been linked to central obesity, insulin resistance, metabolic syndrome, and type 2 diabetes...
  68. Nakagawa Y, Kishida K, Kihara S, Sonoda M, Hirata A, Yasui A, et al. Nocturnal reduction in circulating adiponectin concentrations related to hypoxic stress in severe obstructive sleep apnea-hypopnea syndrome. Am J Physiol Endocrinol Metab. 2008;294:E778-84 pubmed publisher
    Previous reports demonstrated that adiponectin has antiatherosclerotic properties. Obstructive sleep apnea-hypopnea syndrome (OSAHS) is reported to exacerbate atherosclerotic diseases...
  69. Kirdar S, Serter M, Ceylan E, Sener A, Kavak T, Karadag F. Adiponectin as a biomarker of systemic inflammatory response in smoker patients with stable and exacerbation phases of chronic obstructive pulmonary disease. Scand J Clin Lab Invest. 2009;69:219-24 pubmed publisher
    b>Adiponectin is an adipose tissue-derived specific protein that has a role in energy homeostasis, that has a protective role against the development of insulin resistance and atherosclerosis and that exhibits anti-inflammatory properties...
  70. Cook J, Semple R. Hypoadiponectinemia--cause or consequence of human "insulin resistance"?. J Clin Endocrinol Metab. 2010;95:1544-54 pubmed publisher
    b>Adiponectin is a highly abundant plasma protein synthesized nearly exclusively in adipose tissue from the ADIPOQ gene...
  71. Shibata S, Tada Y, Asano Y, Hau C, Kato T, Saeki H, et al. Adiponectin regulates cutaneous wound healing by promoting keratinocyte proliferation and migration via the ERK signaling pathway. J Immunol. 2012;189:3231-41 pubmed publisher
    Diabetic patients are at high risk of developing delayed cutaneous wound healing. Adiponectin plays a pivotal role in the pathogenesis of diabetes and is considered to be involved in various pathological conditions associated with ..
  72. Ikeda K, Maegawa H, Ugi S, Tao Y, Nishio Y, Tsukada S, et al. Transcription factor activating enhancer-binding protein-2beta. A negative regulator of adiponectin gene expression. J Biol Chem. 2006;281:31245-53 pubmed
    ..we demonstrated that overexpression of AP-2beta in 3T3-L1 adipocytes decreased the expression and secretion of adiponectin and increased those of interleukin-6 (IL-6)...
  73. Loos R, Ruchat S, Rankinen T, Tremblay A, Perusse L, Bouchard C. Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Quebec Family Study. Am J Clin Nutr. 2007;85:26-34 pubmed
    Despite adiponectin's presumed role in fatty acid oxidation and energy homeostasis, little is known about the effect of gene variants on substrate oxidation, energy expenditure, and adiposity-related phenotypes...
  74. Tomoda K, Yoshikawa M, Itoh T, Tamaki S, Fukuoka A, Komeda K, et al. Elevated circulating plasma adiponectin in underweight patients with COPD. Chest. 2007;132:135-40 pubmed
    b>Adiponectin is an adipose tissue-derived specific protein that has antiinflammatory as well as anti-atherosclerotic effects. In the United States, many patients with COPD are obese and die of cardiovascular diseases...
  75. Mazaki Tovi S, Kanety H, Pariente C, Hemi R, Efraty Y, Schiff E, et al. Determining the source of fetal adiponectin. J Reprod Med. 2007;52:774-8 pubmed
    To determine whether maternal, placental or fetal compartment contributes to the high levels of cord blood adiponectin. Serum adiponectin levels were compared from 62 newborns and their mothers as well as 32 newborns at delivery and 4 ..
  76. Honsawek S, Chayanupatkul M. Correlation of plasma and synovial fluid adiponectin with knee osteoarthritis severity. Arch Med Res. 2010;41:593-8 pubmed publisher
    ..The purposes of this study were to measure adiponectin concentrations in plasma and synovial fluid of patients with knee OA and to analyze the correlation of ..
  77. Kim B, Lee S, Ryu W, Kim C, Yoon B. Adipocytokines and ischemic stroke: differential associations between stroke subtypes. J Neurol Sci. 2012;312:117-22 pubmed publisher
    ..Venous blood from all participants was drawn after an overnight fast, and serum levels of leptin, adiponectin and resistin were measured by multiple sandwich immunoassay techniques...
  78. Ru Y, Ma M, Ma T, Wang C, Wang Y, Zhang Q, et al. [Association of SNP276 in adiponectin gene with type 2 diabetes mellitus and insulin sensitivity]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2005;22:698-701 pubmed
    To investigate the distribution of SNP276 in adiponectin gene in Chinese Hans and its impact on type 2 diabetes mellitus and insulin sensitivity...
  79. Frystyk J, Berne C, Berglund L, Jensevik K, Flyvbjerg A, Zethelius B. Serum adiponectin is a predictor of coronary heart disease: a population-based 10-year follow-up study in elderly men. J Clin Endocrinol Metab. 2007;92:571-6 pubmed
    Cross-sectional and nested case-control studies indicate a relationship between adiponectin, obesity, and coronary heart disease (CHD)...
  80. Ebinc H, Ebinc F, Ozkurt Z, Dogru M, Tulmac M, Yilmaz M, et al. Impact of adiponectin on left ventricular mass index in non-complicated obese subjects. Endocr J. 2008;55:523-8 pubmed
    To evaluate the relationship between the adiponectin levels and left ventricular mass index (LVMI) in uncomplicated obese subjects...
  81. Choi H, Lee Y, Lee S, Hong S, Hahm D, Choi S, et al. Adiponectin may contribute to synovitis and joint destruction in rheumatoid arthritis by stimulating vascular endothelial growth factor, matrix metalloproteinase-1, and matrix metalloproteinase-13 expression in fibroblast-like synoviocytes more than . Arthritis Res Ther. 2009;11:R161 pubmed publisher
    The role of adiponectin in the pathogenesis of arthritis is still controversial...
  82. Persson J, Lindberg K, Gustafsson T, Eriksson P, Paulsson Berne G, Lundman P. Low plasma adiponectin concentration is associated with myocardial infarction in young individuals. J Intern Med. 2010;268:194-205 pubmed publisher
    The importance of adiponectin in coronary heart disease remains to be elucidated...
  83. Sun K, Li Y, Wei C, Tong Y, Zheng H, Guo Y. Recessive protective effect of ADIPOQ rs1501299 on cardiovascular diseases with type 2 diabetes: a meta-analysis. Mol Cell Endocrinol. 2012;349:162-9 pubmed publisher
    ..It could be presumed that the ADIPOQ rs1501299 (+276G>T) be a potential cause of susceptibility to CVDs in persons with T2D, and it gives a new opportunity to investigate the mechanisms of CVDs susceptibility in T2D patients. ..
  84. Ding C, Li L, Su Y, Xiang R, Cong X, Yu H, et al. Adiponectin increases secretion of rat submandibular gland via adiponectin receptors-mediated AMPK signaling. PLoS ONE. 2013;8:e63878 pubmed publisher
    b>Adiponectin and adiponectin receptors (AdipoR1/2) are expressed in various tissues and are involved in the regulation of multiple functions such as energy metabolism and inflammatory responses...
  85. Schaffler A, Langmann T, Palitzsch K, Scholmerich J, Schmitz G. Identification and characterization of the human adipocyte apM-1 promoter. Biochim Biophys Acta. 1998;1399:187-97 pubmed
    ..In addition, an exon/intron boundary was mapped at the extreme 5'-end of the cDNA sequence. Genomic Southern blotting suggests that the human apM-1 gene is a single copy gene. ..