adiponectin

Summary

Gene Symbol: adiponectin
Description: adiponectin, C1Q and collagen domain containing
Alias: ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28, adiponectin, 30 kDa adipocyte complement-related protein, adipocyte complement-related 30 kDa protein, adipose most abundant gene transcript 1 protein, adipose specific collagen-like factor, gelatin-binding protein 28
Species: human
Products:     adiponectin

Top Publications

  1. Kukla M, Mazur W, Bułdak R, Zwirska Korczala K. Potential role of leptin, adiponectin and three novel adipokines--visfatin, chemerin and vaspin--in chronic hepatitis. Mol Med. 2011;17:1397-410 pubmed publisher
    ..On the other hand, it inhibits synthesis of proinflammatory mediators and enhances adiponectin production, influences adipocyte differentiation and maturation and regulates glucose uptake in adipocytes...
  2. Dastani Z, Hivert M, Timpson N, Perry J, Yuan X, Scott R, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 2012;8:e1002607 pubmed publisher
    Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits...
  3. Poehls J, Wassel C, Harris T, Havel P, Swarbrick M, Cummings S, et al. Association of adiponectin with mortality in older adults: the Health, Aging, and Body Composition Study. Diabetologia. 2009;52:591-5 pubmed publisher
    Despite inverse associations with insulin resistance and adiposity, adiponectin has been associated with both increased and decreased risk of cardiovascular disease...
  4. Tsubakio Yamamoto K, Matsuura F, Koseki M, Oku H, Sandoval J, Inagaki M, et al. Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages. Biochem Biophys Res Commun. 2008;375:390-4 pubmed publisher
    ..b>Adiponectin (APN) secreted from adipocytes is one of the important molecules to inhibit the development of atherosclerosis...
  5. Pérez Martínez P, López Miranda J, Cruz Teno C, Delgado Lista J, Jiménez Gómez Y, Fernández J, et al. Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men. J Nutr. 2008;138:1609-14 pubmed
    b>Adiponectin (adipoQ) gene variants have been associated with type 2 diabetes mellitus and insulin resistance...
  6. Margaritis M, Antonopoulos A, Digby J, Lee R, Reilly S, Coutinho P, et al. Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels. Circulation. 2013;127:2209-21 pubmed publisher
    b>Adiponectin is an adipokine with potentially important roles in human cardiovascular disease states. We studied the role of adiponectin in the cross-talk between adipose tissue and vascular redox state in patients with atherosclerosis...
  7. Windham B, Griswold M, Farasat S, Ling S, Carlson O, Egan J, et al. Influence of leptin, adiponectin, and resistin on the association between abdominal adiposity and arterial stiffness. Am J Hypertens. 2010;23:501-7 pubmed publisher
    ..adipokine production, the objectives of this study were to examine the influence of adipokines such as leptin, adiponectin, and resistin on the relationship between abdominal adiposity and arterial stiffness...
  8. Napoli N, Pedone C, Pozzilli P, Lauretani F, Ferrucci L, Incalzi R. Adiponectin and bone mass density: The InCHIANTI study. Bone. 2010;47:1001-5 pubmed publisher
    b>Adiponectin serum concentration has been reported to be inversely correlated with bone mineral density (BMD) in humans. The data on this issue, however, are biased by small study sample size and lack of controlling for body composition...
  9. Mazaki Tovi S, Romero R, Vaisbuch E, Erez O, Mittal P, Chaiworapongsa T, et al. Maternal serum adiponectin multimers in gestational diabetes. J Perinat Med. 2009;37:637-50 pubmed publisher
    b>Adiponectin, an adipokine with profound insulin-sensitizing effect, consists of heterogeneous species of multimers...

More Information

Publications173 found, 100 shown here

  1. Tian L, Luo N, Klein R, Chung B, Garvey W, Fu Y. Adiponectin reduces lipid accumulation in macrophage foam cells. Atherosclerosis. 2009;202:152-61 pubmed publisher
    b>Adiponectin is one of several, important metabolically active cytokines secreted from adipocytes...
  2. Sabouri S, Ghayour Mobarhan M, Moohebati M, Hassani M, Kassaeian J, Tatari F, et al. Association between 45T/G polymorphism of adiponectin gene and coronary artery disease in an Iranian population. ScientificWorldJournal. 2011;11:93-101 pubmed publisher
    A single nucleotide polymorphism (SNP) in the adiponectin gene, 45T/G, has been reported in relation to a number of metabolic disorders, including obesity, insulin resistance, and diabetes...
  3. Wassel C, Pankow J, Rasmussen Torvik L, Li N, Taylor K, Guo X, et al. Associations of SNPs in ADIPOQ and subclinical cardiovascular disease in the multi-ethnic study of atherosclerosis (MESA). Obesity (Silver Spring). 2011;19:840-7 pubmed publisher
    Circulating adiponectin is associated with both clinical and subclinical cardiovascular disease (CVD)...
  4. Dastani Z, Johnson T, Kronenberg F, Nelson C, Assimes T, März W, et al. The shared allelic architecture of adiponectin levels and coronary artery disease. Atherosclerosis. 2013;229:145-8 pubmed publisher
    ..Low adiponectin levels, a hormone secreted only from adipocytes, have been associated with an increased risk of CAD in ..
  5. Matharoo K, Arora P, Bhanwer A. Association of adiponectin (AdipoQ) and sulphonylurea receptor (ABCC8) gene polymorphisms with Type 2 Diabetes in North Indian population of Punjab. Gene. 2013;527:228-34 pubmed publisher
    In Type 2 Diabetes (T2D), adiponectin (AdipoQ) and sulphonylurea receptor genes (ABCC8) are important targets for candidate gene association studies...
  6. Koskinen A, Juslin S, Nieminen R, Moilanen T, Vuolteenaho K, Moilanen E. Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways. Arthritis Res Ther. 2011;13:R184 pubmed publisher
    b>Adiponectin is an adipokine that regulates energy metabolism and insulin sensitivity, but recent studies have pointed also to a role in inflammation and arthritis...
  7. Mills K, Hamm L, Alper A, Miller C, Hudaihed A, Balamuthusamy S, et al. Circulating adipocytokines and chronic kidney disease. PLoS ONE. 2013;8:e76902 pubmed publisher
    ..We investigated the association of plasma leptin, resistin and adiponectin with CKD in 201 patients with CKD and 201 controls without...
  8. Vetvik K, Sonerud T, Lindeberg M, Lüders T, Størkson R, Jonsdottir K, et al. Globular adiponectin and its downstream target genes are up-regulated locally in human colorectal tumors: ex vivo and in vitro studies. Metabolism. 2014;63:672-81 pubmed publisher
    Low plasma adiponectin levels are linked to obesity, insulin resistance, and the risk of several types of malignancy...
  9. Donoso M, Muñoz Calvo M, Barrios V, Martinez G, Hawkins F, Argente J. Increased leptin/adiponectin ratio and free leptin index are markers of insulin resistance in obese girls during pubertal development. Horm Res Paediatr. 2013;80:363-70 pubmed publisher
    ..We hypothesized that the leptin/adiponectin (L/A) ratio and free leptin index (FLI) are good markers of insulin resistance (IR) and total body fat (TBF) ..
  10. Sulistyoningrum D, Gasevic D, Lear S, Ho J, Mente A, Devlin A. Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study. Cardiovasc Diabetol. 2013;12:170 pubmed publisher
    ..b>Adiponectin is an insulin sensitizing adipocytokine that circulates as multiple isoforms, with high molecular weight (HMW) ..
  11. Ye E, Yang H, Chen L, Chen Q, Sun M, Lin Z, et al. Adiponectin and peroxisome proliferator-activated receptor-? gene polymorphisms and gene-gene interactions with type 2 diabetes. Life Sci. 2014;98:55-9 pubmed publisher
    To investigate whether gene polymorphisms of both adiponectin and peroxisome proliferator-activated receptor gamma (PPAR?) influence type 2 diabetes mellitus (T2DM) respectively in the Han people of the Wenzhou region of China and ..
  12. Ahasic A, Zhao Y, Su L, Sheu C, Thompson B, Christiani D. Adiponectin gene polymorphisms and acute respiratory distress syndrome susceptibility and mortality. PLoS ONE. 2014;9:e89170 pubmed publisher
    b>Adiponectin is an anti-inflammatory adipokine that is the most abundant gene product of adipose tissue. Lower levels have been observed in obesity, insulin resistance, and in critical illness...
  13. Yokota T, Oritani K, Takahashi I, Ishikawa J, Matsuyama A, Ouchi N, et al. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages. Blood. 2000;96:1723-32 pubmed
    We investigated the functions of adiponectin, an adipocyte-specific secretory protein and a new member of the family of soluble defense collagens, in hematopoiesis and immune responses...
  14. Segawa K, Matsuda M, Fukuhara A, Morita K, Okuno Y, Komuro R, et al. Identification of a novel distal enhancer in human adiponectin gene. J Endocrinol. 2009;200:107-16 pubmed publisher
    b>Adiponectin is exclusively expressed in adipose tissue and secreted from adipocytes, and shows anti-diabetic and anti-atherogenic properties. However, the precise transcriptional mechanism of adiponectin remains elusive...
  15. Richards J, Waterworth D, O Rahilly S, Hivert M, Loos R, Perry J, et al. A genome-wide association study reveals variants in ARL15 that influence adiponectin levels. PLoS Genet. 2009;5:e1000768 pubmed publisher
    The adipocyte-derived protein adiponectin is highly heritable and inversely associated with risk of type 2 diabetes mellitus (T2D) and coronary heart disease (CHD)...
  16. Li X, Ren N, Ling W, Chen F, Zhang W, Fan X, et al. Adiponectin and its receptors in chronic hepatitis B patients with metabolic syndrome in China. Hepatogastroenterology. 2012;59:1735-43 pubmed publisher
    b>Adiponectin can initiate a broad range of metabolic and immunological effects. Little is known about the role of adiponectin in hepatitis B related liver disease and metabolic syndrome (MS)...
  17. Hennige A, Staiger H, Wicke C, Machicao F, Fritsche A, Haring H, et al. Fetuin-A induces cytokine expression and suppresses adiponectin production. PLoS ONE. 2008;3:e1765 pubmed publisher
    ..of adipose tissue expression and plasma concentration of the insulin-sensitizing and atheroprotective adipokine adiponectin. Human monocytic THP1 cells and human in vitro differenttiated adipocytes as well as C57BL/6 mice were treated ..
  18. Kawamoto R, Tabara Y, Kohara K, Miki T, Kusunoki T, Katho T, et al. Serum high molecular weight adiponectin correlates with arterial stiffness in community-dwelling persons. Endocr Res. 2011;36:53-63 pubmed publisher
    INTRODUCTION. Serum high molecular weight (HMW) adiponectin, an adipocytokine, which is a protein secreted specifically by adipose tissue, improves insulin sensitivity and plays an important role in the development of metabolic syndrome ..
  19. Ebina K, Fukuhara A, Ando W, Hirao M, Koga T, Oshima K, et al. Serum adiponectin concentrations correlate with severity of rheumatoid arthritis evaluated by extent of joint destruction. Clin Rheumatol. 2009;28:445-51 pubmed publisher
    b>Adiponectin is a hormone released by adipose tissue with antidiabetic, antiatherogenic, and anti-inflammatory properties...
  20. Brakenhielm E, Veitonmaki N, Cao R, Kihara S, Matsuzawa Y, Zhivotovsky B, et al. Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc Natl Acad Sci U S A. 2004;101:2476-81 pubmed
    ..The adipose tissue produces several growth factors/hormones including leptin, tumor necrosis factor alpha, and adiponectin. It has been found that adiponectin levels are reduced in obesity...
  21. Qi L, Doria A, Manson J, Meigs J, Hunter D, Mantzoros C, et al. Adiponectin genetic variability, plasma adiponectin, and cardiovascular risk in patients with type 2 diabetes. Diabetes. 2006;55:1512-6 pubmed
    b>Adiponectin is an adipocyte-derived hormone that has shown anti-inflammatory and antiatherogenic effects...
  22. Kappelle P, Dullaart R, van Beek A, Hillege H, Wolffenbuttel B. The plasma leptin/adiponectin ratio predicts first cardiovascular event in men: a prospective nested case-control study. Eur J Intern Med. 2012;23:755-9 pubmed publisher
    The plasma leptin/adiponectin (L/A) ratio has been proposed as a preferential marker of atherosclerosis susceptibility compared to leptin and adiponectin alone...
  23. Gonzalez Gay M, Llorca J, Garcia Unzueta M, Gonzalez Juanatey C, De Matias J, Martin J, et al. High-grade inflammation, circulating adiponectin concentrations and cardiovascular risk factors in severe rheumatoid arthritis. Clin Exp Rheumatol. 2008;26:596-603 pubmed
    To assess whether obesity and systemic inflammation are potential determinants of circulating adiponectin concentrations and whether low adiponectin levels cluster with metabolic syndrome features that are previously documented ..
  24. Beatty A, Zhang M, Ku I, Na B, Schiller N, Whooley M. Adiponectin is associated with increased mortality and heart failure in patients with stable ischemic heart disease: data from the Heart and Soul Study. Atherosclerosis. 2012;220:587-92 pubmed publisher
    Serum adiponectin protects against incident ischemic heart disease (IHD). However, in patients with existing IHD, higher adiponectin levels are paradoxically associated with worse outcomes...
  25. Leu H, Chung C, Chuang S, Bai C, Chen J, Chen J, et al. Genetic variants of connexin37 are associated with carotid intima-medial thickness and future onset of ischemic stroke. Atherosclerosis. 2011;214:101-6 pubmed publisher
    ..of atherosclerosis-related genes including connexin37 (GJA4), C-reactive protein (CRP), paraoxonase (PON1), adiponectin (ACDC), angiotensin-converting enzyme (ACE), beta-adrenergic receptor (ADRB1, ADRB2), antithrombin III (..
  26. Kantorova E, Chomova M, Kurca E, Sivák S, Zeleňák K, Kucera P, et al. Leptin, adiponectin and ghrelin, new potential mediators of ischemic stroke. Neuro Endocrinol Lett. 2011;32:716-21 pubmed
    Fat tissue is an important endocrine organ that produces a number of hormones and cytokines (leptin, adiponectin, resistin, plasminogen activator inhibitor-1, Tumour necrosis factor TNF ?) with essential roles in regulation of many ..
  27. Gupta V, Khadgawat R, Ng H, Kumar S, Aggarwal A, Rao V, et al. A validation study of type 2 diabetes-related variants of the TCF7L2, HHEX, KCNJ11, and ADIPOQ genes in one endogamous ethnic group of north India. Ann Hum Genet. 2010;74:361-8 pubmed publisher
    ..In spite of a culturally-learned sedentary lifestyle and fat-enriched dietary habits, WHR rather than body-mass-index emerged as a robust predictor of risk for T2D in this population. ..
  28. Jain S, Massaro J, Hoffmann U, Rosito G, Vasan R, Raji A, et al. Cross-sectional associations between abdominal and thoracic adipose tissue compartments and adiponectin and resistin in the Framingham Heart Study. Diabetes Care. 2009;32:903-8 pubmed publisher
    To test the association of regional fat depots with circulating adiponectin and resistin concentrations and to assess the potential mediating effect of adipokines on associations between abdominal fat depots and cardiometabolic risk ..
  29. Toussirot E, Gaugler B, Bouhaddi M, Nguyen N, Saas P, Dumoulin G. Elevated adiponectin serum levels in women with systemic autoimmune diseases. Mediators Inflamm. 2010;2010:938408 pubmed publisher
    ..In this study, we assessed the serum levels of leptin, adiponectin, and ghrelin, in association with the measurements of body composition, in 15 female patients with various ..
  30. Vasseur F, Caeyseele T, Barat Houari M, Lobbens S, Meirhaeghe A, Meyre D, et al. Concordance of two multiple analytical approaches demonstrate that interaction between BMI and ADIPOQ haplotypes is a determinant of LDL cholesterol in a general French population. J Hum Genet. 2010;55:227-31 pubmed publisher
    ..Including genetic and environmental variables (gender, body mass index (BMI) and adiponectin level) we used (1) the multifactor dimensionality reduction method to explain clusters of high and low LDL-C, ..
  31. Tang C, Chiu Y, Tan T, Yang R, Fu W. Adiponectin enhances IL-6 production in human synovial fibroblast via an AdipoR1 receptor, AMPK, p38, and NF-kappa B pathway. J Immunol. 2007;179:5483-92 pubmed
    Articular adipose tissue is a ubiquitous component of human joints, and adiponectin is a protein hormone secreted predominantly by differentiated adipocytes and involved in energy homeostasis...
  32. Arakawa H, Jinnin M, Muchemwa F, Makino T, Kajihara I, Makino K, et al. Adiponectin expression is decreased in the involved skin and sera of diffuse cutaneous scleroderma patients. Exp Dermatol. 2011;20:764-6 pubmed publisher
    In this study, we determined the adiponectin expression in the serum and lesional skin of patients with scleroderma (SSc)...
  33. Tworoger S, Mantzoros C, Hankinson S. Relationship of plasma adiponectin with sex hormone and insulin-like growth factor levels. Obesity (Silver Spring). 2007;15:2217-24 pubmed
    Recent studies have suggested that a relationship between adiponectin and sex hormone, prolactin, and insulin-like growth factor levels could be important for breast cancer risk and insulin sensitivity...
  34. Mracek T, Ding Q, Tzanavari T, Kos K, Pinkney J, Wilding J, et al. The adipokine zinc-alpha2-glycoprotein (ZAG) is downregulated with fat mass expansion in obesity. Clin Endocrinol (Oxf). 2010;72:334-41 pubmed publisher
    ..The study also examined the association between ZAG and adiponectin expression in human adipose tissue, and whether ZAG modulates adiponectin secretion by human adipocytes...
  35. Chan K, Yeung S, Yao T, Ip M, Cheung A, Chan Yeung M, et al. Elevated plasma adiponectin levels in patients with chronic obstructive pulmonary disease. Int J Tuberc Lung Dis. 2010;14:1193-200 pubmed
    b>Adiponectin is an anti-inflammatory adipokine that may play a role in chronic obstructive pulmonary disease (COPD) pathogenesis...
  36. Kawanami D, Maemura K, Takeda N, Harada T, Nojiri T, Imai Y, et al. Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. Biochem Biophys Res Commun. 2004;314:415-9 pubmed
    ..Moreover, the induction of VCAM-1 and ICAM-1 by resistin was inhibited by adiponectin, an adipocytokine that improves insulin resistance...
  37. Tanko L, Siddiq A, Lecoeur C, Larsen P, Christiansen C, Walley A, et al. ACDC/adiponectin and PPAR-gamma gene polymorphisms: implications for features of obesity. Obes Res. 2005;13:2113-21 pubmed
    ..Total body fat mass and the central to peripheral fat mass ratio (CFM/PFM ratio) were measured using DXA. Adiponectin and homeostasis model assessment of insulin resistance were measured in 287 subjects...
  38. Grossmann M, Nkhata K, Mizuno N, Ray A, Cleary M. Effects of adiponectin on breast cancer cell growth and signaling. Br J Cancer. 2008;98:370-9 pubmed publisher
    Obesity is a risk factor for postmenopausal breast cancer. Adiponectin/Acrp30 is lower in obese individuals and may be negatively regulating breast cancer growth...
  39. Wanninger J, Neumeier M, Weigert J, Bauer S, Weiss T, Schaffler A, et al. Adiponectin-stimulated CXCL8 release in primary human hepatocytes is regulated by ERK1/ERK2, p38 MAPK, NF-kappaB, and STAT3 signaling pathways. Am J Physiol Gastrointest Liver Physiol. 2009;297:G611-8 pubmed publisher
    b>Adiponectin is believed to exert hepatoprotective effects and induces CXCL8, a chemokine that functions as a survival factor, in vascular cells...
  40. Hao D, Li M, Wu Z, Duan Y, Li D, Qiu G. Synovial fluid level of adiponectin correlated with levels of aggrecan degradation markers in osteoarthritis. Rheumatol Int. 2011;31:1433-7 pubmed publisher
    The objective of this study was to investigate adiponectin levels in both plasma and synovial fluid of female patients with knee osteoarthritis (OA) and to analyze the correlation between adiponectin and degradation markers of cartilage ..
  41. Cheng X, Folco E, Shimizu K, Libby P. Adiponectin induces pro-inflammatory programs in human macrophages and CD4+ T cells. J Biol Chem. 2012;287:36896-904 pubmed publisher
    Abundant experimental and clinical data support a modulatory role for adiponectin in inflammation, dysmetabolism, and disease...
  42. Lihn A, Østergård T, Nyholm B, Pedersen S, Richelsen B, Schmitz O. Adiponectin expression in adipose tissue is reduced in first-degree relatives of type 2 diabetic patients. Am J Physiol Endocrinol Metab. 2003;284:E443-8 pubmed
    b>Adiponectin is suggested to be an important mediator of insulin resistance...
  43. Duncan B, Schmidt M, Pankow J, Bang H, Couper D, Ballantyne C, et al. Adiponectin and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes. 2004;53:2473-8 pubmed
    Adipocyte-derived secretory proteins have been increasingly linked to diabetes. To investigate whether adiponectin, a major adipocyte secretory protein, predicts diabetes, we conducted a case-cohort study representing the approximately 9-..
  44. Ukkola O, Teran Garcia M, Tremblay A, Despres J, Bouchard C. Adiponectin concentration and insulin indicators following overfeeding in identical twins. J Endocrinol Invest. 2008;31:132-7 pubmed
    Low adiponectin levels have been associated with high body mass index, low insulin sensitivity, and diabetes...
  45. Bostrom M, Freedman B, Langefeld C, Liu L, Hicks P, Bowden D. Association of adiponectin gene polymorphisms with type 2 diabetes in an African American population enriched for nephropathy. Diabetes. 2009;58:499-504 pubmed publisher
    Polymorphisms in the adiponectin gene (ADIPOQ) have been associated with type 2 diabetes and diabetic nephropathy in type 1 diabetes, in mostly European-derived populations...
  46. Wang M, Helzlsouer K, Smith M, Hoffman Bolton J, Clipp S, Grinberg V, et al. Association of IL10 and other immune response- and obesity-related genes with prostate cancer in CLUE II. Prostate. 2009;69:874-85 pubmed publisher
    ..Although none of the SNPs in the obesity genes tested was associated, this does not rule out a complex role of obesity and its metabolic consequences in prostate cancer etiology. ..
  47. Chen H, Montagnani M, Funahashi T, Shimomura I, Quon M. Adiponectin stimulates production of nitric oxide in vascular endothelial cells. J Biol Chem. 2003;278:45021-6 pubmed
    b>Adiponectin is secreted by adipose cells and mimics many metabolic actions of insulin. However, mechanisms by which adiponectin acts are poorly understood...
  48. Heid I, Wagner S, Gohlke H, Iglseder B, Mueller J, Cip P, et al. Genetic architecture of the APM1 gene and its influence on adiponectin plasma levels and parameters of the metabolic syndrome in 1,727 healthy Caucasians. Diabetes. 2006;55:375-84 pubmed
    The associations of the adiponectin (APM1) gene with parameters of the metabolic syndrome are inconsistent...
  49. Xi B, He D, Wang Q, Xue J, Liu M, Li J. Common polymorphisms (rs2241766 and rs1501299) in the ADIPOQ gene are not associated with hypertension susceptibility among the Chinese. Mol Biol Rep. 2012;39:8771-5 pubmed publisher
    ..The present meta-analysis indicated the limited evidence of the significant associations between ADIPOQ gene polymorphisms and hypertension susceptibility among the Chinese. ..
  50. Lihn A, Richelsen B, Pedersen S, Haugaard S, Rathje G, Madsbad S, et al. Increased expression of TNF-alpha, IL-6, and IL-8 in HALS: implications for reduced adiponectin expression and plasma levels. Am J Physiol Endocrinol Metab. 2003;285:E1072-80 pubmed
    ..b>Adiponectin, an adipocyte-specific protein, is thought to play an important role in regulating insulin sensitivity...
  51. Looker H, Krakoff J, Funahashi T, Matsuzawa Y, Tanaka S, Nelson R, et al. Adiponectin concentrations are influenced by renal function and diabetes duration in Pima Indians with type 2 diabetes. J Clin Endocrinol Metab. 2004;89:4010-7 pubmed
    b>Adiponectin is produced exclusively by adipocytes, and its serum concentration is inversely associated with adiposity. This study examines the relationship among diabetes, renal function, and serum adiponectin in Pima Indians...
  52. Abke S, Neumeier M, Weigert J, Wehrwein G, Eggenhofer E, Schaffler A, et al. Adiponectin-induced secretion of interleukin-6 (IL-6), monocyte chemotactic protein-1 (MCP-1, CCL2) and interleukin-8 (IL-8, CXCL8) is impaired in monocytes from patients with type I diabetes. Cardiovasc Diabetol. 2006;5:17 pubmed
    Systemic adiponectin is reduced in patients with cardiovascular disease (CVD) and low adiponectin may contribute to the pathogenesis of atherosclerosis...
  53. Anderson P, Mehta N, Wolfe M, Hinkle C, Pruscino L, Comiskey L, et al. Innate immunity modulates adipokines in humans. J Clin Endocrinol Metab. 2007;92:2272-9 pubmed
    ..We measured plasma leptin, adiponectin, resistin, soluble leptin receptor, cytokines, insulin, and glucose; distribution of adiponectin among ..
  54. Magge S, Stettler N, Koren D, Levitt Katz L, Gallagher P, Mohler E, et al. Adiponectin is associated with favorable lipoprotein profile, independent of BMI and insulin resistance, in adolescents. J Clin Endocrinol Metab. 2011;96:1549-54 pubmed publisher
    Children with obesity and insulin resistance (IR) have decreased adiponectin and have increased cardiovascular risk. Adiponectin has antiatherogenic effects, but its mechanism is unclear...
  55. He B, Pan Y, Zhang Y, Bao Q, Chen L, Nie Z, et al. Effects of genetic variations in the adiponectin pathway genes on the risk of colorectal cancer in the Chinese population. BMC Med Genet. 2011;12:94 pubmed publisher
    Decreased expression of adiponectin (ADIPOQ) is associated with an increased risk for developing colorectal cancer (CRC) in humans...
  56. Gui M, Li X, Jiang S, Gao J, Lu D, Gao X. Association of the adiponectin gene rs1501299 G>T variant, serum adiponectin levels, and the risk of coronary artery disease in a Chinese population. Diabetes Res Clin Pract. 2012;97:499-504 pubmed publisher
    ..study aimed to investigate whether the single nucleotide polymorphism (SNP) 276G>T (rs1501299) of the adiponectin (ADIPOQ) gene was associated with the risk of coronary artery disease (CAD) and serum adiponectin levels in a ..
  57. Martin L, Woo J, Geraghty S, Altaye M, Davidson B, Banach W, et al. Adiponectin is present in human milk and is associated with maternal factors. Am J Clin Nutr. 2006;83:1106-11 pubmed
    ..If present in milk, adiponectin would be a promising candidate for influencing infant development, given its metabolic functions...
  58. Kouidhi S, Jarboui S, Marrakchi R, Froidevaux M, Seugnet I, Abid H, et al. Adiponectin expression and metabolic markers in obesity and Type 2 diabetes. J Endocrinol Invest. 2011;34:e16-23 pubmed publisher
    b>Adiponectin has emerged over the last decade as a key adipokine linking obesity, insulin resistance, and Type 2 diabetes. However, the molecular mechanisms controlling adiponectin expression in adipose tissue are not fully elucidated...
  59. Daniele A, De Rosa A, Nigro E, Scudiero O, Capasso M, Masullo M, et al. Adiponectin oligomerization state and adiponectin receptors airway expression in chronic obstructive pulmonary disease. Int J Biochem Cell Biol. 2012;44:563-9 pubmed publisher
    b>Adiponectin (Acrp30) shows several beneficial properties and circulates as different oligomers. The role of Acrp30 in lung is not fully clear, but a link with chronic obstructive pulmonary disease (COPD) has been highlighted...
  60. Spranger J, Verma S, Göhring I, Bobbert T, Seifert J, Sindler A, et al. Adiponectin does not cross the blood-brain barrier but modifies cytokine expression of brain endothelial cells. Diabetes. 2006;55:141-7 pubmed
    b>Adiponectin has recently been reported to generate a negative energy balance by increasing energy expenditure...
  61. Tabara Y, Osawa H, Kawamoto R, Tachibana Iimori R, Yamamoto M, Nakura J, et al. Reduced high-molecular-weight adiponectin and elevated high-sensitivity C-reactive protein are synergistic risk factors for metabolic syndrome in a large-scale middle-aged to elderly population: the Shimanami Health Promoting Program Study. J Clin Endocrinol Metab. 2008;93:715-22 pubmed
    ..b>Adiponectin is an adipose tissue-specific plasma protein that inversely associates with metabolic syndrome...
  62. Zietz B, Buechler C, Kobuch K, Neumeier M, Scholmerich J, Schaffler A. Serum levels of adiponectin are associated with diabetic retinopathy and with adiponectin gene mutations in Caucasian patients with diabetes mellitus type 2. Exp Clin Endocrinol Diabetes. 2008;116:532-6 pubmed publisher
    ..Since adiponectin represents an adipocyte-specific secretory protein modulating endothelial cell functions, it was the aim of the ..
  63. Liao Y, Liang K, Lee W, Lee W, Lee I, Wang J, et al. Leptin to adiponectin ratio as a useful predictor for cardiac syndrome X. Biomarkers. 2013;18:44-50 pubmed publisher
    ..Adipokines were measured by ELISA tests. The CSX had lower circulating adiponectin but higher leptin and higher leptin/adiponectin ratio (×1000) (3.78 ± 4.96 vs. 2.14 ± 5.67, p < 0...
  64. Zadjali F, Al Yahyaee S, Hassan M, Albarwani S, Bayoumi R. Association of adiponectin promoter variants with traits and clusters of metabolic syndrome in Arabs: family-based study. Gene. 2013;527:663-9 pubmed publisher
    Plasma levels of adiponectin are decreased in type 2 diabetes, obesity and hypertension...
  65. Scherer P, Williams S, Fogliano M, Baldini G, Lodish H. A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem. 1995;270:26746-9 pubmed
    We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation...
  66. Hara K, Boutin P, Mori Y, Tobe K, Dina C, Yasuda K, et al. Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes. 2002;51:536-40 pubmed
    An adipocyte-derived peptide, adiponectin (also known as GBP28), is decreased in subjects with type 2 diabetes...
  67. Koh K, Han S, Quon M, Yeal Ahn J, Shin E. Beneficial effects of fenofibrate to improve endothelial dysfunction and raise adiponectin levels in patients with primary hypertriglyceridemia. Diabetes Care. 2005;28:1419-24 pubmed
    ..001). Compared with placebo, fenofibrate therapy significantly increased plasma levels of adiponectin by 14 +/- 5% (P = 0...
  68. Frystyk J, Tarnow L, Hansen T, Parving H, Flyvbjerg A. Increased serum adiponectin levels in type 1 diabetic patients with microvascular complications. Diabetologia. 2005;48:1911-8 pubmed
    Low serum adiponectin (ADPN) has been associated with increased risk of cardiovascular disease (CVD) and retinopathy in patients with type 2 diabetes mellitus...