adiponectin

Summary

Gene Symbol: adiponectin
Description: adiponectin, C1Q and collagen domain containing
Alias: ACDC, ACRP30, ADIPQTL1, ADPN, APM-1, APM1, GBP28, adiponectin, 30 kDa adipocyte complement-related protein, adipocyte complement-related 30 kDa protein, adipose most abundant gene transcript 1 protein, adipose specific collagen-like factor, gelatin-binding protein 28
Species: human
Products:     adiponectin

Top Publications

  1. Kukla M, Mazur W, Bułdak R, Zwirska Korczala K. Potential role of leptin, adiponectin and three novel adipokines--visfatin, chemerin and vaspin--in chronic hepatitis. Mol Med. 2011;17:1397-410 pubmed publisher
    ..On the other hand, it inhibits synthesis of proinflammatory mediators and enhances adiponectin production, influences adipocyte differentiation and maturation and regulates glucose uptake in adipocytes...
  2. Dastani Z, Hivert M, Timpson N, Perry J, Yuan X, Scott R, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. PLoS Genet. 2012;8:e1002607 pubmed publisher
    Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits...
  3. Poehls J, Wassel C, Harris T, Havel P, Swarbrick M, Cummings S, et al. Association of adiponectin with mortality in older adults: the Health, Aging, and Body Composition Study. Diabetologia. 2009;52:591-5 pubmed publisher
    Despite inverse associations with insulin resistance and adiposity, adiponectin has been associated with both increased and decreased risk of cardiovascular disease...
  4. Tsubakio Yamamoto K, Matsuura F, Koseki M, Oku H, Sandoval J, Inagaki M, et al. Adiponectin prevents atherosclerosis by increasing cholesterol efflux from macrophages. Biochem Biophys Res Commun. 2008;375:390-4 pubmed publisher
    ..b>Adiponectin (APN) secreted from adipocytes is one of the important molecules to inhibit the development of atherosclerosis...
  5. Pérez Martínez P, López Miranda J, Cruz Teno C, Delgado Lista J, Jiménez Gómez Y, Fernández J, et al. Adiponectin gene variants are associated with insulin sensitivity in response to dietary fat consumption in Caucasian men. J Nutr. 2008;138:1609-14 pubmed
    b>Adiponectin (adipoQ) gene variants have been associated with type 2 diabetes mellitus and insulin resistance...
  6. Margaritis M, Antonopoulos A, Digby J, Lee R, Reilly S, Coutinho P, et al. Interactions between vascular wall and perivascular adipose tissue reveal novel roles for adiponectin in the regulation of endothelial nitric oxide synthase function in human vessels. Circulation. 2013;127:2209-21 pubmed publisher
    b>Adiponectin is an adipokine with potentially important roles in human cardiovascular disease states. We studied the role of adiponectin in the cross-talk between adipose tissue and vascular redox state in patients with atherosclerosis...
  7. Windham B, Griswold M, Farasat S, Ling S, Carlson O, Egan J, et al. Influence of leptin, adiponectin, and resistin on the association between abdominal adiposity and arterial stiffness. Am J Hypertens. 2010;23:501-7 pubmed publisher
    ..adipokine production, the objectives of this study were to examine the influence of adipokines such as leptin, adiponectin, and resistin on the relationship between abdominal adiposity and arterial stiffness...
  8. Napoli N, Pedone C, Pozzilli P, Lauretani F, Ferrucci L, Incalzi R. Adiponectin and bone mass density: The InCHIANTI study. Bone. 2010;47:1001-5 pubmed publisher
    b>Adiponectin serum concentration has been reported to be inversely correlated with bone mineral density (BMD) in humans. The data on this issue, however, are biased by small study sample size and lack of controlling for body composition...
  9. Mazaki Tovi S, Romero R, Vaisbuch E, Erez O, Mittal P, Chaiworapongsa T, et al. Maternal serum adiponectin multimers in gestational diabetes. J Perinat Med. 2009;37:637-50 pubmed publisher
    b>Adiponectin, an adipokine with profound insulin-sensitizing effect, consists of heterogeneous species of multimers...

More Information

Publications425 found, 100 shown here

  1. Tian L, Luo N, Klein R, Chung B, Garvey W, Fu Y. Adiponectin reduces lipid accumulation in macrophage foam cells. Atherosclerosis. 2009;202:152-61 pubmed publisher
    b>Adiponectin is one of several, important metabolically active cytokines secreted from adipocytes...
  2. Sabouri S, Ghayour Mobarhan M, Moohebati M, Hassani M, Kassaeian J, Tatari F, et al. Association between 45T/G polymorphism of adiponectin gene and coronary artery disease in an Iranian population. ScientificWorldJournal. 2011;11:93-101 pubmed publisher
    A single nucleotide polymorphism (SNP) in the adiponectin gene, 45T/G, has been reported in relation to a number of metabolic disorders, including obesity, insulin resistance, and diabetes...
  3. Tabatabaei Malazy O, Hasani Ranjbar S, Amoli M, Heshmat R, Sajadi M, Derakhshan R, et al. Gender-specific differences in the association of adiponectin gene polymorphisms with body mass index. Rev Diabet Stud. 2010;7:241-6 pubmed publisher
    b>Adiponectin gene polymorphisms are associated with obesity, metabolic syndrome and type 2 diabetes (T2D)...
  4. Wassel C, Pankow J, Rasmussen Torvik L, Li N, Taylor K, Guo X, et al. Associations of SNPs in ADIPOQ and subclinical cardiovascular disease in the multi-ethnic study of atherosclerosis (MESA). Obesity (Silver Spring). 2011;19:840-7 pubmed publisher
    Circulating adiponectin is associated with both clinical and subclinical cardiovascular disease (CVD)...
  5. Dastani Z, Johnson T, Kronenberg F, Nelson C, Assimes T, März W, et al. The shared allelic architecture of adiponectin levels and coronary artery disease. Atherosclerosis. 2013;229:145-8 pubmed publisher
    ..Low adiponectin levels, a hormone secreted only from adipocytes, have been associated with an increased risk of CAD in ..
  6. Youn J, Kim C, Park S, Lee S, Kang S, Choi D, et al. Adiponectin and progression of arterial stiffness in hypertensive patients. Int J Cardiol. 2013;163:316-319 pubmed publisher
    ..We hypothesized that in hypertensive patients, initial levels of adipokines such as adiponectin and resistin are related to the progression of arterial stiffness, which has been proven to be associated with ..
  7. Matharoo K, Arora P, Bhanwer A. Association of adiponectin (AdipoQ) and sulphonylurea receptor (ABCC8) gene polymorphisms with Type 2 Diabetes in North Indian population of Punjab. Gene. 2013;527:228-34 pubmed publisher
    In Type 2 Diabetes (T2D), adiponectin (AdipoQ) and sulphonylurea receptor genes (ABCC8) are important targets for candidate gene association studies...
  8. Koskinen A, Juslin S, Nieminen R, Moilanen T, Vuolteenaho K, Moilanen E. Adiponectin associates with markers of cartilage degradation in osteoarthritis and induces production of proinflammatory and catabolic factors through mitogen-activated protein kinase pathways. Arthritis Res Ther. 2011;13:R184 pubmed publisher
    b>Adiponectin is an adipokine that regulates energy metabolism and insulin sensitivity, but recent studies have pointed also to a role in inflammation and arthritis...
  9. Mills K, Hamm L, Alper A, Miller C, Hudaihed A, Balamuthusamy S, et al. Circulating adipocytokines and chronic kidney disease. PLoS ONE. 2013;8:e76902 pubmed publisher
    ..We investigated the association of plasma leptin, resistin and adiponectin with CKD in 201 patients with CKD and 201 controls without...
  10. Vetvik K, Sonerud T, Lindeberg M, Lüders T, Størkson R, Jonsdottir K, et al. Globular adiponectin and its downstream target genes are up-regulated locally in human colorectal tumors: ex vivo and in vitro studies. Metabolism. 2014;63:672-81 pubmed publisher
    Low plasma adiponectin levels are linked to obesity, insulin resistance, and the risk of several types of malignancy...
  11. Donoso M, Muñoz Calvo M, Barrios V, Martinez G, Hawkins F, Argente J. Increased leptin/adiponectin ratio and free leptin index are markers of insulin resistance in obese girls during pubertal development. Horm Res Paediatr. 2013;80:363-70 pubmed publisher
    ..We hypothesized that the leptin/adiponectin (L/A) ratio and free leptin index (FLI) are good markers of insulin resistance (IR) and total body fat (TBF) ..
  12. Sulistyoningrum D, Gasevic D, Lear S, Ho J, Mente A, Devlin A. Total and high molecular weight adiponectin and ethnic-specific differences in adiposity and insulin resistance: a cross-sectional study. Cardiovasc Diabetol. 2013;12:170 pubmed publisher
    ..b>Adiponectin is an insulin sensitizing adipocytokine that circulates as multiple isoforms, with high molecular weight (HMW) ..
  13. Ye E, Yang H, Chen L, Chen Q, Sun M, Lin Z, et al. Adiponectin and peroxisome proliferator-activated receptor-? gene polymorphisms and gene-gene interactions with type 2 diabetes. Life Sci. 2014;98:55-9 pubmed publisher
    To investigate whether gene polymorphisms of both adiponectin and peroxisome proliferator-activated receptor gamma (PPAR?) influence type 2 diabetes mellitus (T2DM) respectively in the Han people of the Wenzhou region of China and ..
  14. Ahasic A, Zhao Y, Su L, Sheu C, Thompson B, Christiani D. Adiponectin gene polymorphisms and acute respiratory distress syndrome susceptibility and mortality. PLoS ONE. 2014;9:e89170 pubmed publisher
    b>Adiponectin is an anti-inflammatory adipokine that is the most abundant gene product of adipose tissue. Lower levels have been observed in obesity, insulin resistance, and in critical illness...
  15. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Hara K, et al. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med. 2001;7:941-6 pubmed
    b>Adiponectin is an adipocyte-derived hormone. Recent genome-wide scans have mapped a susceptibility locus for type 2 diabetes and metabolic syndrome to chromosome 3q27, where the gene encoding adiponectin is located...
  16. Wang C, Li L, Zhang Z, Fan D, Zhu Y, Wu L. Globular adiponectin inhibits angiotensin II-induced nuclear factor kappaB activation through AMP-activated protein kinase in cardiac hypertrophy. J Cell Physiol. 2010;222:149-55 pubmed publisher
    ..b>Adiponectin, an adipocyte-derived polypeptide, suppresses cardiac hypertrophy in response to pressure overload...
  17. Addabbo F, Nacci C, De Benedictis L, Leo V, Tarquinio M, Quon M, et al. Globular adiponectin counteracts VCAM-1-mediated monocyte adhesion via AdipoR1/NF-?B/COX-2 signaling in human aortic endothelial cells. Am J Physiol Endocrinol Metab. 2011;301:E1143-54 pubmed publisher
    b>Adiponectin (Ad) is an insulin-sensitizing adipocytokine with anti-inflammatory and vasoprotective properties. Cleavage of native full-length Ad (fAd) by elastases from activated monocytes generates globular Ad (gAd)...
  18. Nannipieri M, Posadas R, Bonotti A, Williams K, Gonzalez Villalpando C, Stern M, et al. Polymorphism of the 3'-untranslated region of the leptin receptor gene, but not the adiponectin SNP45 polymorphism, predicts type 2 diabetes: a population-based study. Diabetes Care. 2006;29:2509-11 pubmed
  19. Mente A, Razak F, Blankenberg S, Vuksan V, Davis A, Miller R, et al. Ethnic variation in adiponectin and leptin levels and their association with adiposity and insulin resistance. Diabetes Care. 2010;33:1629-34 pubmed publisher
    To investigate ethnic differences in adiponectin and leptin concentration and to determine whether these adipokines and a high-glycemic index diet account for ethnic variation in insulin resistance...
  20. Haugen F, Drevon C. Activation of nuclear factor-kappaB by high molecular weight and globular adiponectin. Endocrinology. 2007;148:5478-86 pubmed
    ..b>Adiponectin is an exceptional adipokine because low plasma concentrations are associated with obesity, type 2 diabetes, and ..
  21. Pääkkö T, Ukkola O, Ikäheimo M, Kesaniemi Y. Plasma adiponectin levels are associated with left ventricular hypertrophy in a random sample of middle-aged subjects. Ann Med. 2010;42:131-7 pubmed publisher
    A low adiponectin level is associated with high blood pressure which, in turn, often results in left ventricular hypertrophy...
  22. Lim S, Koo B, Cho S, Kihara S, Funahashi T, Cho Y, et al. Association of adiponectin and resistin with cardiovascular events in Korean patients with type 2 diabetes: the Korean atherosclerosis study (KAS): a 42-month prospective study. Atherosclerosis. 2008;196:398-404 pubmed
    b>Adiponectin and resistin are proteins that affect insulin resistance and atherosclerosis significantly...
  23. Saito O, Saito T, Okuda K, Okuda K, Kotoda A, Akimoto T, et al. Serum adiponectin and markers of endothelial injury in hemodialysis patients with arteriosclerosis obliterans. Clin Exp Nephrol. 2008;12:58-64 pubmed publisher
    ..b>Adiponectin is an adipose-derived cytokine which, because of its modulation of endothelial adhesion molecules, has ..
  24. Wu X, Motoshima H, Mahadev K, Stalker T, Scalia R, Goldstein B. Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes. 2003;52:1355-63 pubmed
    b>Adiponectin is an abundant adipocyte-derived plasma protein with anti-atherosclerotic and insulin-sensitizing properties that suppresses hepatic glucose production and enhances glucose uptake into skeletal muscle...
  25. Takeuchi F, Ochiai Y, Serizawa M, Yanai K, Kuzuya N, Kajio H, et al. Search for type 2 diabetes susceptibility genes on chromosomes 1q, 3q and 12q. J Hum Genet. 2008;53:314-24 pubmed publisher
    ..Independent replication will clarify the etiological relevance of these genomic loci to T2D. ..
  26. Beebe Dimmer J, Zuhlke K, Ray A, Lange E, Cooney K. Genetic variation in adiponectin (ADIPOQ) and the type 1 receptor (ADIPOR1), obesity and prostate cancer in African Americans. Prostate Cancer Prostatic Dis. 2010;13:362-8 pubmed publisher
    b>Adiponectin is a protein derived from adipose tissue suspected to have an important role in prostate carcinogenesis...
  27. Park K, Park K, Kim M, Kim H, Suh Y, Ahn J, et al. Relationship between serum adiponectin and leptin concentrations and body fat distribution. Diabetes Res Clin Pract. 2004;63:135-42 pubmed
    The aim of this study was to investigate the relationship between adiponectin and leptin and body fat distribution. One hundred and ninety-seven women participated in this study...
  28. Basu S, Laffineuse L, Presley L, Minium J, Catalano P, Hauguel De Mouzon S. In utero gender dimorphism of adiponectin reflects insulin sensitivity and adiposity of the fetus. Obesity (Silver Spring). 2009;17:1144-9 pubmed publisher
    Circulating adiponectin reflects the degree of energy homeostasis and insulin sensitivity of adult individuals...
  29. Shim C, Park S, Kim J, Shin D, Ko Y, Kang S, et al. Association of plasma retinol-binding protein 4, adiponectin, and high molecular weight adiponectin with insulin resistance in non-diabetic hypertensive patients. Yonsei Med J. 2010;51:375-84 pubmed publisher
    The aim of this study was to determine whether retinol-binding protein 4 (RBP4), adiponectin and high molecular weight (HMW) adiponectin are associated with insulin resistance (IR) and metabolic parameters in non-diabetic hypertensive ..
  30. Miranda Filloy J, López Mejías R, Genre F, Carnero López B, Ochoa R, Diaz de Teran T, et al. Adiponectin and resistin serum levels in non-diabetic ankylosing spondylitis patients undergoing TNF-? antagonist therapy. Clin Exp Rheumatol. 2013;31:365-71 pubmed
    ..if disease activity, systemic inflammation and metabolic syndrome are potential determinants of circulating adiponectin and resistin levels in ankylosing spondylitis (AS) patients undergoing TNF-? antagonist therapy...
  31. Wang Y, Lam K, Chan L, Chan K, Lam J, Lam M, et al. Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex. J Biol Chem. 2006;281:16391-400 pubmed
    b>Adiponectin is a multifunctional adipokine that circulates as several oligomeric complexes in the blood stream. However, the molecular basis that regulates the production of the adiponectin oligomers remains largely elusive...
  32. Yaturu S, Reddy R, Rains J, Jain S. Plasma and urine levels of resistin and adiponectin in chronic kidney disease. Cytokine. 2007;37:1-5 pubmed
    ..Adipocyte hormones, resistin and adiponectin are implicated in insulin resistance and atherosclerosis...
  33. Kistorp C, Faber J, Galatius S, Gustafsson F, Frystyk J, Flyvbjerg A, et al. Plasma adiponectin, body mass index, and mortality in patients with chronic heart failure. Circulation. 2005;112:1756-62 pubmed
    ..The adipocytokine adiponectin is inversely associated with BMI, and in healthy subjects, low adiponectin is a predictor of mortality...
  34. Kim J, Ahn S, Yoon J, Koh S, Yoon J, Yoo B, et al. Prospective study of serum adiponectin and incident metabolic syndrome: the ARIRANG study. Diabetes Care. 2013;36:1547-53 pubmed publisher
    Increased adiponectin levels may play a protective role in the development of metabolic abnormalities, but prospective studies of the predictive value of serum adiponectin to identify individuals at high risk of new-onset metabolic ..
  35. Qiao L, MacLean P, Schaack J, Orlicky D, Darimont C, Pagliassotti M, et al. C/EBPalpha regulates human adiponectin gene transcription through an intronic enhancer. Diabetes. 2005;54:1744-54 pubmed
    b>Adiponectin is an adipose-derived hormone that enhances insulin sensitivity and plays an important role in regulating energy homeostasis...
  36. Escobar Morreale H, Villuendas G, Botella Carretero J, Alvarez Blasco F, Sanchón R, Luque Ramirez M, et al. Adiponectin and resistin in PCOS: a clinical, biochemical and molecular genetic study. Hum Reprod. 2006;21:2257-65 pubmed
    We conducted a cross-sectional case-control study to evaluate the possible involvement of adiponectin and resistin in the pathogenesis of polycystic ovary syndrome (PCOS)...
  37. Hu E, Liang P, Spiegelman B. AdipoQ is a novel adipose-specific gene dysregulated in obesity. J Biol Chem. 1996;271:10697-703 pubmed
    ..Whereas the biological function of this polypeptide is presently unknown, the tissue-specific expression of a putative secreted protein suggests that this factor may function as a novel signaling molecule for adipose tissue. ..
  38. Ma J, Möllsten A, Falhammar H, Brismar K, Dahlquist G, Efendic S, et al. Genetic association analysis of the adiponectin polymorphisms in type 1 diabetes with and without diabetic nephropathy. J Diabetes Complications. 2007;21:28-33 pubmed
    b>Adiponectin [adipocyte C1q and collagen domain containing (ACDC)] is the most abundant adipose-specific protein...
  39. Chow W, Cheung B, Tso A, Xu A, Wat N, Fong C, et al. Hypoadiponectinemia as a predictor for the development of hypertension: a 5-year prospective study. Hypertension. 2007;49:1455-61 pubmed
    Low circulating levels of adiponectin, an adipokine with insulin-sensitizing, antiatherogenic, and anti-inflammatory properties, are found in hypertensive patients...
  40. Considine R, Premkumar A, Reynolds J, Sebring N, Ricks M, Sumner A. Adiponectin and leptin in African Americans. Obesity (Silver Spring). 2008;16:428-34 pubmed publisher
    African Americans (AAs) have less visceral and more subcutaneous fat than whites, thus the relationship of adiponectin and leptin to body fat and insulin sensitivity in AA may be different from that in whites...
  41. Frommer K, Zimmermann B, Meier F, Schröder D, Heil M, Schaffler A, et al. Adiponectin-mediated changes in effector cells involved in the pathophysiology of rheumatoid arthritis. Arthritis Rheum. 2010;62:2886-99 pubmed publisher
    ..key players in the pathophysiology of RA, this study was undertaken to analyze the effects of the key adipokine adiponectin on proinflammatory and prodestructive synovial effector cells...
  42. Cieslak J, Skorczyk A, Stachowiak M, Szydlowski M, Grzes M, Paczynska P, et al. Polymorphisms in 5'-flanking regions of genes encoding adiponectin, leptin, and resistin are not associated with obesity of Polish children and adolescents. Mol Biol Rep. 2011;38:1793-8 pubmed publisher
    ..In this study we screened for polymorphism 5'-flanking regions of the adiponectin (ADIPOQ), leptin (LEP) and resistin (RETN) genes in a cohort of Polish obese children and adolescents (n = 243) ..
  43. Gornick M, Rennert G, Moreno V, Gruber S. Adiponectin gene and risk of colorectal cancer. Br J Cancer. 2011;105:562-4 pubmed publisher
    Genes of the adiponectin pathway are interesting candidates for colorectal cancer risk based on the potential association between colorectal cancer and obesity...
  44. Arita Y, Kihara S, Ouchi N, Maeda K, Kuriyama H, Okamoto Y, et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation. 2002;105:2893-8 pubmed
    ..We previously reported that adiponectin, an adipocyte-specific plasma protein, accumulated in the human injured artery and suppressed endothelial ..
  45. Efstathiou S, Skeva I, Dimas C, Panagiotou A, Parisi K, Tzanoumis L, et al. Smoking cessation increases serum adiponectin levels in an apparently healthy Greek population. Atherosclerosis. 2009;205:632-6 pubmed publisher
    Smoking has been associated with low serum levels of adiponectin, an adipocytokine with insulin-sensitizing, anti-inflammatory and anti-atherogenic properties...
  46. Iwaki M, Matsuda M, Maeda N, Funahashi T, Matsuzawa Y, Makishima M, et al. Induction of adiponectin, a fat-derived antidiabetic and antiatherogenic factor, by nuclear receptors. Diabetes. 2003;52:1655-63 pubmed
    b>Adiponectin is a fat-derived hormone with antidiabetic and antiatherogenic properties. Hypoadiponectinemia seen in obesity is associated with insulin-resistant diabetes and atherosclerosis...
  47. Ding M, Xie Y, Wagner R, Jin Y, Carrao A, Liu L, et al. Adiponectin induces vascular smooth muscle cell differentiation via repression of mammalian target of rapamycin complex 1 and FoxO4. Arterioscler Thromb Vasc Biol. 2011;31:1403-10 pubmed publisher
    The adipocyte-secreted hormone adiponectin exerts important cardioprotective and antidiabetic effects. Little is known about its effect on vascular smooth muscle cells (VSMC), key cells in restenosis, hypertension, and atherosclerosis...
  48. Piñeiro R, Iglesias M, Gallego R, Raghay K, Eiras S, Rubio J, et al. Adiponectin is synthesized and secreted by human and murine cardiomyocytes. FEBS Lett. 2005;579:5163-9 pubmed
    b>Adiponectin is thought to play a decisive role in the relationships among obesity, insulin resistance and cardiovascular risk...
  49. Ozkurt B, Ozkurt Z, Altay M, Aktekin C, Caglayan O, Tabak Y. The relationship between serum adiponectin level and anthropometry, bone mass, osteoporotic fracture risk in postmenopausal women. Eklem Hastalik Cerrahisi. 2009;20:78-84 pubmed
    The aim of the present study was to evaluate the possible correlation between bone mass and serum adiponectin levels, and the correlation between adiponectin levels and osteoporotic fracture risk in a prospective clinical trial...
  50. Ruchat S, Loos R, Rankinen T, Vohl M, Weisnagel S, Despres J, et al. Associations between glucose tolerance, insulin sensitivity and insulin secretion phenotypes and polymorphisms in adiponectin and adiponectin receptor genes in the Quebec Family Study. Diabet Med. 2008;25:400-6 pubmed publisher
    Studies suggest that adiponectin (APM1) and its receptors 1 and 2 (AdipoR1 and AdipoR2) play an important role in the development of insulin resistance (IR)...
  51. Gonullu G, Kahraman H, Bedir A, Bektas A, Yucel I. Association between adiponectin, resistin, insulin resistance, and colorectal tumors. Int J Colorectal Dis. 2010;25:205-12 pubmed publisher
    In this study, we have examined the correlation between colorectal cancer (CRC) and serum adiponectin and resistin levels, body mass index and insulin resistance...
  52. Saraheimo M, Forsblom C, Fagerudd J, Teppo A, Pettersson Fernholm K, Frystyk J, et al. Serum adiponectin is increased in type 1 diabetic patients with nephropathy. Diabetes Care. 2005;28:1410-4 pubmed
    To elucidate whether serum adiponectin is associated with renal function, low-grade inflammatory markers, metabolic control, and insulin resistance in type 1 diabetic patients with and without nephropathy...
  53. Yang W, Yang Y, Chen C, Wu I, Lu J, Lu F, et al. Adiponectin SNP276 is associated with obesity, the metabolic syndrome, and diabetes in the elderly. Am J Clin Nutr. 2007;86:509-13 pubmed
    Genetic variations of the human adiponectin gene are associated with metabolic phenotypes, including obesity, insulin sensitivity, and diabetes. However, these associations have not been examined in an elderly population...
  54. Li L, Kang X, Ran X, Wang Y, Wang C, Huang L, et al. Associations between 45T/G polymorphism of the adiponectin gene and plasma adiponectin levels with type 2 diabetes. Clin Exp Pharmacol Physiol. 2007;34:1287-90 pubmed
    ..study was to investigate the association between the single nucleotide polymorphism (SNP) 45T/G and plasma adiponectin levels and the prevalence of Type 2 diabetes mellitus (T2DM) in Uygurs of the Xinjiang region, China. 2...
  55. Phillips S, Kung J, Ciaraldi T, Choe C, Christiansen L, Mudaliar S, et al. Selective regulation of cellular and secreted multimeric adiponectin by antidiabetic therapies in humans. Am J Physiol Endocrinol Metab. 2009;297:E767-73 pubmed publisher
    b>Adiponectin, an insulin-sensitizing factor secreted from adipose tissue, is decreased in individuals with type 2 diabetes (T2D) and increased in response to thiazolidinedione (TZD) therapy...
  56. Al Daghri N, Al Attas O, Alokail M, Alkharfy K, Hussain T, Yakout S, et al. Adiponectin gene polymorphisms (T45G and G276T), adiponectin levels and risk for metabolic diseases in an Arab population. Gene. 2012;493:142-7 pubmed publisher
    In this study we examined the association of adiponectin gene variants with circulating adiponectin, and known metabolic diseases in 298 healthy controls and 297 Saudi subjects with type 2 diabetes mellitus (T2DM)...
  57. Ouchi N, Kobayashi H, Kihara S, Kumada M, Sato K, Inoue T, et al. Adiponectin stimulates angiogenesis by promoting cross-talk between AMP-activated protein kinase and Akt signaling in endothelial cells. J Biol Chem. 2004;279:1304-9 pubmed
    b>Adiponectin is an adipocyte-specific adipocytokine with anti-atherogenic and anti-diabetic properties. Here, we investigated whether adiponectin regulates angiogenic processes in vitro and in vivo...
  58. Okamoto Y, Arita Y, Nishida M, Muraguchi M, Ouchi N, Takahashi M, et al. An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls. Horm Metab Res. 2000;32:47-50 pubmed
    ..gene product possesses significant homology to collagens VIII, X and complement factor C1q, and we named it adiponectin. In the current study, we analyzed characteristics of adiponectin in vitro and in vivo...
  59. Lee Y, Lee N, Cho Y, Moon M, Jung H, Park Y, et al. Genetic association study of adiponectin polymorphisms with risk of Type 2 diabetes mellitus in Korean population. Diabet Med. 2005;22:569-75 pubmed
    ..any association between Type 2 diabetes mellitus and two single nucleotide polymorphisms (SNPs) in the adiponectin gene, T45G and G276T, in the Korean population...
  60. Yamauchi T, Kamon J, Minokoshi Y, Ito Y, Waki H, Uchida S, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 2002;8:1288-95 pubmed
    b>Adiponectin (Ad) is a hormone secreted by adipocytes that regulates energy homeostasis and glucose and lipid metabolism. However, the signaling pathways that mediate the metabolic effects of Ad remain poorly identified...
  61. Engeli S, Feldpausch M, Gorzelniak K, Hartwig F, Heintze U, Janke J, et al. Association between adiponectin and mediators of inflammation in obese women. Diabetes. 2003;52:942-7 pubmed
    Low plasma levels of the anti-inflammatory factor adiponectin characterize obesity and insulin resistance...
  62. Otsuka F, Sugiyama S, Kojima S, Maruyoshi H, Funahashi T, Sakamoto T, et al. Hypoadiponectinemia is associated with impaired glucose tolerance and coronary artery disease in non-diabetic men. Circ J. 2007;71:1703-9 pubmed
    ..An anti-atherogenic adipocytokine, adiponectin, is decreased in type 2 diabetes mellitus, but its role in non-diabetic subjects has not been clarified...
  63. Yang M, Qiu C, Chen W, Xu L, Yu M, Xiang H. Identification of a regulatory single nucleotide polymorphism in the adiponectin (APM1) gene associated with type 2 diabetes in Han nationality. Biomed Environ Sci. 2008;21:454-9 pubmed publisher
    To identify the genetic defects of the the adiponectin (APM1) gene that contribute to the development of type 2 diabetes (T2DM) and determine the functional single nucleotide polymorphisms (SNPs) in the APM1 gene associated with T2DM in ..
  64. Bouatia Naji N, Meyre D, Lobbens S, Séron K, Fumeron F, Balkau B, et al. ACDC/adiponectin polymorphisms are associated with severe childhood and adult obesity. Diabetes. 2006;55:545-50 pubmed
    Common single nucleotide polymorphisms (SNPs) in the ACDC adiponectin encoding gene have been associated with insulin resistance and type 2 diabetes in several populations...
  65. Vionnet N, Tregouet D, Kazeem G, Gut I, Groop P, Tarnow L, et al. Analysis of 14 candidate genes for diabetic nephropathy on chromosome 3q in European populations: strongest evidence for association with a variant in the promoter region of the adiponectin gene. Diabetes. 2006;55:3166-74 pubmed
    ..Polymorphisms in three genes, glucose transporter 2 (SLC2A2), kininogen (KNG1), and adiponectin (ADIPOQ), showed nominal association with diabetic nephropathy in single-point analysis...
  66. Shen Y, Hughes J, Charlesworth J, Kelly J, Peake P. Adiponectin is present in the urine in its native conformation, and specifically reduces the secretion of MCP-1 by proximal tubular cells. Nephrology (Carlton). 2008;13:405-10 pubmed publisher
    To determine whether adiponectin detected in urine is present in its native form and if adiponectin receptors (AdipoR) present and functional in proximal tubular (HK-2) cells...
  67. Sharma K, Ramachandrarao S, Qiu G, Usui H, Zhu Y, Dunn S, et al. Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest. 2008;118:1645-56 pubmed publisher
    ..However, the link between early albuminuria and adiposity remains unclear. To determine whether adiponectin, an adipocyte-derived hormone, is a communication signal between adipocytes and the kidney, we performed ..