ADH4

Summary

Gene Symbol: ADH4
Description: alcohol dehydrogenase 4 (class II), pi polypeptide
Alias: ADH-2, HEL-S-4, alcohol dehydrogenase 4, alcohol dehydrogenase class II pi chain, aldehyde reductase, epididymis secretory protein Li 4
Species: human

Top Publications

  1. ncbi ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Pharmacogenet Genomics 15:755-68. 2005
  2. pmc ADH single nucleotide polymorphism associations with alcohol metabolism in vivo
    Andrew J Birley
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Hum Mol Genet 18:1533-42. 2009
  3. pmc Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
  4. ncbi ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1085-95. 2006
  5. ncbi Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population
    Yehuda D Neumark
    Braun School of Public Health and Community Medicine, Hebrew University of Jerusalem Hadassah, Jerusalem, Israel
    Alcohol Clin Exp Res 28:10-4. 2004
  6. pmc Personality traits of agreeableness and extraversion are associated with ADH4 variation
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:599-608. 2007
  7. pmc Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample
    Po Hsiu Kuo
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
    Alcohol Clin Exp Res 32:785-95. 2008
  8. ncbi Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients
    Camila Guindalini
    Human Genome Research Center, Department of Biology, Institute of Biosciences, University of Sao Paulo, Rua do Matao, Travessa 13, Number 106, Cidade Universitária CEP 05508 090, Sao Paulo SP, Brazil
    Am J Psychiatry 162:1005-7. 2005
  9. pmc Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism
    G Mårdh
    Proc Natl Acad Sci U S A 83:8908-12. 1986
  10. ncbi Cutaneous metabolism of glycol ethers
    David J Lockley
    Skin Toxicology Group, Department of Environmental and Occupational Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    Arch Toxicol 79:160-8. 2005

Detail Information

Publications189 found, 100 shown here

  1. ncbi ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Pharmacogenet Genomics 15:755-68. 2005
    We found strong associations between ADH4 gene variation and alcohol and drug dependence by the Hardy-Weinberg Disequilibrium (HWD) test and case-control association analysis in an initial study...
  2. pmc ADH single nucleotide polymorphism associations with alcohol metabolism in vivo
    Andrew J Birley
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Hum Mol Genet 18:1533-42. 2009
    ..SNPs were associated with the early stages of alcohol metabolism, with additional effects in the ADH1A, ADH1B and ADH4 regions...
  3. pmc Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
    ..001) between alcohol consumption phenotypes and rs1693482 (ADH1C), rs1230165 (ADH5) and rs3762894 (ADH4)...
  4. ncbi ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1085-95. 2006
    ..The ADH4 gene, an important member of this family, is a functional and positional candidate for alcohol dependence...
  5. ncbi Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population
    Yehuda D Neumark
    Braun School of Public Health and Community Medicine, Hebrew University of Jerusalem Hadassah, Jerusalem, Israel
    Alcohol Clin Exp Res 28:10-4. 2004
    ..The mechanism by which this allelic effect is mediated is not yet clearly understood. This study examined the effect of ADH2*2 on alcohol-elimination rates (AER) under experimental conditions...
  6. pmc Personality traits of agreeableness and extraversion are associated with ADH4 variation
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:599-608. 2007
    ..Strong associations between ADH4 variation and SD have been reported...
  7. pmc Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample
    Po Hsiu Kuo
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
    Alcohol Clin Exp Res 32:785-95. 2008
    ..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence...
  8. ncbi Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients
    Camila Guindalini
    Human Genome Research Center, Department of Biology, Institute of Biosciences, University of Sao Paulo, Rua do Matao, Travessa 13, Number 106, Cidade Universitária CEP 05508 090, Sao Paulo SP, Brazil
    Am J Psychiatry 162:1005-7. 2005
    The authors evaluated the association of three functional promoter polymorphisms of the ADH4 gene with alcohol dependence.
  9. pmc Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism
    G Mårdh
    Proc Natl Acad Sci U S A 83:8908-12. 1986
    ..These features and the presence of pi ADH in human liver imply a physiological role for pi ADH in the degradation of circulating epinephrine and norepinephrine...
  10. ncbi Cutaneous metabolism of glycol ethers
    David J Lockley
    Skin Toxicology Group, Department of Environmental and Occupational Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    Arch Toxicol 79:160-8. 2005
    ..However, ADH1, ADH3 and ADH4 predominate in rat skin, demonstrate different sensitivities to pyrazole, and are responsible for metabolising ..
  11. pmc The intra- and extracellular proteome of Aspergillus niger growing on defined medium with xylose or maltose as carbon substrate
    Xin Lu
    Helmholtz Center for Infection Research, Inhoffenstr, Braunschweig, Germany
    Microb Cell Fact 9:23. 2010
    ..13 growing on defined medium with xylose or maltose as carbon substrate was carried out using 2-D gel electrophoresis/Maldi-ToF and nano-HPLC MS/MS...
  12. pmc Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors
    L I McLellan
    Department of Clinical Biochemistry, University of Edinburgh, Royal Infirmary, U K
    Biochem J 300:117-24. 1994
    ..In addition, the effect of these drugs on the hepatic levels of an aldehyde reductase (AFB1-AR) that metabolizes the cytotoxic dialdehydic form of AFB1 has been studied as this enzyme also ..
  13. ncbi Molecular and metabolic retinoid pathways in the human ocular surface
    Hachemi Nezzar
    Universite d Auvergne, JE 2447, ARDEMO, France
    Mol Vis 13:1641-50. 2007
    ..The second objective was to demonstrate the presence of different enzymes transforming vitamin A to retinoic acid and the functionality of this metabolic pathway in the corneal epithelium...
  14. ncbi Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members
    Teruhiko Iino
    Department of General Studies, Nihon University, Sakurajosui 3 25 40, Setagaya Ku, Tokyo 156 8550, Japan
    Arch Biochem Biophys 416:180-7. 2003
    ..by 3 alpha-hydroxysteroid dehydrogenase type 2, whereas 1(')-OXPH(4) was produced by aldose reductase, aldehyde reductase, and 20 alpha-hydroxysteroid dehydrogenase, and both 1(')-OXPH(4) and 2(')-OXPH(4) were detected as the ..
  15. ncbi Vitamin C. Biosynthesis, recycling and degradation in mammals
    Carole L Linster
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Brussels, Belgium
    FEBS J 274:1-22. 2007
    ..Glucuronate is converted to l-gulonate by aldehyde reductase, an enzyme of the aldo-keto reductase superfamily...
  16. ncbi Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1
    J D Hayes
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Chem Biol Interact 111:51-67. 1998
    ..In addition to GSTA5, we have identified a novel aflatoxin-aldehyde reductase (AFAR) that is similarly induced by ethoxyquin...
  17. ncbi The role of liver alcohol dehydrogenase isoenzymes in the oxidation of glycolethers in male and female rats
    L Aasmoe
    Department of Clinical Pharmacology, University Hospital, University of Tromsø, Norway
    Toxicol Appl Pharmacol 150:86-90. 1998
    ..However, it was the same ADH isoenzyme (ADH-3) that oxidized the different glycolethers tested in both male and female rat livers, and the substrate specificity was 2-BE > 2-EE > 2-ME...
  18. ncbi Tracing the history of an enzyme polymorphism: the case of alcohol dehydrogenase-2 (Adh-2) of the olive fruit fly Bactrocera oleae
    George N Goulielmos
    Department of Genetics, Agricultural University of Athens, Athens, Greece
    Mol Biol Evol 20:293-306. 2003
    ..The estimated age of the polymorphism is compatible with this hypothesis, but firmer support could be difficult to obtain...
  19. ncbi ADH4-lacZ transgenic mouse reveals alcohol dehydrogenase localization in embryonic midbrain/hindbrain, otic vesicles, and mesencephalic, trigeminal, facial, and olfactory neural crest
    R J Haselbeck
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 22:1607-13. 1998
    ..Herein, we have used transgenic mice to examine the mouse gene encoding class IV ADH (ADH4), an enzyme that is weakly effective as an ethanol dehydrogenase, but highly effective as a retinol dehydrogenase ..
  20. pmc Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice
    Andrei Molotkov
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 277:13804-11. 2002
    The ability of class I alcohol dehydrogenase (ADH1) and class IV alcohol dehydrogenase (ADH4) to metabolize retinol to retinoic acid is supported by genetic studies in mice carrying Adh1 or Adh4 gene disruptions...
  21. ncbi Impaired retinol utilization in Adh4 alcohol dehydrogenase mutant mice
    L Deltour
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    Dev Genet 25:1-10. 1999
    b>Adh4, a member of the mouse alcohol dehydrogenase (ADH) gene family, encodes an enzyme that functions in vitro as a retinol dehydrogenase in the conversion of retinol to retinoic acid, an important developmental signaling molecule...
  22. ncbi Rat liver alcohol dehydrogenase of class III. Primary structure, functional consequences and relationships to other alcohol dehydrogenases
    P Julia
    Department of Chemistry I, Karolinska Institutet, Stockholm, Sweden
    Eur J Biochem 172:73-83. 1988
    ..Finally the class III structure supports evolutionary relationships suggesting that the three classes constitute clearly separate enzymes within the group of mammalian zinc-containing alcohol dehydrogenases...
  23. ncbi Characterization of the functional gene encoding mouse class III alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase) and an unexpressed processed pseudogene with an intact open reading frame
    M H Foglio
    La Jolla Cancer Foundation Research Foundation, CA 92037, USA
    Eur J Biochem 237:496-504. 1996
    ..Reporter gene expression following transfection into mouse F9 embryonal carcinoma cells indicated that only Adh-2 possesses promoter activity...
  24. doi The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells
    Jan Vondracek
    Department of Cytokinetics, Institute of Biophysics ASCR, Brno, Czech Republic
    Chem Biol Interact 180:226-37. 2009
    ..In contrast, the aldehyde reductase AKR1A1 was not induced by either treatment...
  25. ncbi Aldose reductase: an aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia
    Minoru Kawamura
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Auton Neurosci 96:131-9. 2002
    ..Although similar formation of DHPG was observed with human liver aldehyde reductase, the production of DHPG was more effective with aldose reductase than aldehyde reductase...
  26. ncbi Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter
    Elizabeth M Ellis
    Department of Bioscience and Pharmaceutical Sciences, University of Strathclyde, Glasgow G1 1XW, UK
    Carcinogenesis 24:727-37. 2003
    Rat aflatoxin B(1) aldehyde reductase (called AFAR1 or AKR7A1) is a member of the aldo-keto reductase 7 family, which metabolizes the environmental carcinogen aflatoxin B(1)...
  27. doi Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometry
    Denise N Johnson
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 21:752-60. 2008
    ..This urinary detection of the alcohol products directly contributes to the goal of mass balancing the fate of the bioreactive 8,9-epoxides of AFB 1 in vivo...
  28. pmc Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins
    Vincent P Kelly
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Biochem J 366:847-61. 2002
    The aldo-keto reductase (AKR) 7 family is composed of the dimeric aflatoxin B(1) aldehyde reductase (AFAR) isoenzymes. In the rat, two AFAR subunits exist, designated rAFAR1 and rAFAR2...
  29. ncbi Aldose reductase in human retinal pigment epithelial cells
    S Sato
    Laboratory of Ocular Therapeutics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
    Exp Eye Res 57:235-41. 1993
    ..In addition to aldose reductase, chromatofocusing demonstrated the presence of aldehyde reductase, another NADPH-dependent reductase...
  30. ncbi Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase
    C J Winters
    Department of Medicine, Medical College of Virginia, Richmond 23298
    Biochemistry 29:1080-7. 1990
    ..The deduced protein sequence of CDR showed 65% similarity to the primary structure of human liver aldehyde reductase and 66% similarity to the inferred protein sequence of rat lens aldose reductase...
  31. ncbi Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells
    C Praml
    Division of Cytogenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Res 58:5014-8. 1998
    ..a gene encoding a protein of 330 amino acids that is 78% identical with the Rattus norvegicus aflatoxin B1 aldehyde reductase (Afar) and, therefore, likely represents its human homologue...
  32. pmc Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities
    Kevork Hagopian
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Biosci Rep 28:107-15. 2008
    ..Aldehyde dehydrogenase and aldehyde reductase activities in both young and old CR mice were unchanged by caloric restriction...
  33. ncbi Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity
    W R Lacy
    Department of Cell Biology, Baylor College of Medicine Houston, Texas 77030
    Mol Endocrinol 7:58-66. 1993
    ..to human chlordecone reductase, bovine lung prostaglandin F synthase, human aldose reductase, human aldehyde reductase, and frog lens rho-crystallin, placing rabbit ovarian 20 alpha HSD in the aldo-keto reductase family of ..
  34. ncbi Enzymes in pancreatic islets that use NADP(H) as a cofactor including evidence for a plasma membrane aldehyde reductase
    M Laclau
    University of Wisconsin Childrens Diabetes Center, Madison, USA
    Mol Cell Biochem 225:151-60. 2001
    ..Significant activities of glutathione reductase, aldose reductase (EC.1.1.1.21) and aldehyde reductase (EC.1.1.1.2) were present in islets...
  35. ncbi Purification and characterization of human testis aldose and aldehyde reductase
    T Tanimoto
    Division of Biological Chemistry, National Institute of Hygienic Sciences, Tokyo, Japan
    Int J Biochem 23:421-8. 1991
    1. Aldose reductase and aldehyde reductase were purified to homogeneity from human testis. 2...
  36. ncbi Alcohol dehydrogenases in Xenopus development: conserved expression of ADH1 and ADH4 in epithelial retinoid target tissues
    I Hoffmann
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    Dev Dyn 213:261-70. 1998
    Mammalian alcohol dehydrogenases ADH1 (class I ADH) and ADH4 (class IV ADH) function as retinol dehydrogenases contributing to the synthesis of retinoic acid, the active form of vitamin A involved in growth and development...
  37. ncbi Characterization of the serotoninergic system in the C57BL/6 mouse skin
    Andrzej Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, TN, USA
    Eur J Biochem 270:3335-44. 2003
    ..acid, probably through stepwise transformation catalyzed by monoamine oxidase, aldehyde dehydrogenase and aldehyde reductase. Activity of the melatonin-forming enzyme hydroxyindole-O-methyltransferase was notably below detectable ..
  38. pmc Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat
    Bill D Roebuck
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Toxicol Sci 109:41-9. 2009
    ..These results imply that the prevention of protein adducts mediated by AKR are not critical to protection against AFB(1) tumorigenicity...
  39. ncbi Isolation of a set of genes expressed in the choroid plexus of the mouse using suppression subtractive hybridization
    N Matsumoto
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Neuroscience 117:405-15. 2003
    ..gelsolin, phospholipid transfer protein, ATP-binding cassette transporter A8 (ABCA8), androgen-inducible aldehyde reductase, and Na(+)/sulfate cotransporter SUT-1...
  40. pmc A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant
    D J Judah
    MRC Toxicology Unit, Carshalton, Surrey, U K
    Biochem J 292:13-8. 1993
    In contrast with fractions from control animals, an aldehyde reductase, which catalyses the reduction of aflatoxin B1-dihydrodiol, in the dialdehyde form at physiological pH values, to aflatoxin B1-dialcohol, is expressed in cytosolic ..
  41. ncbi Purification and characterization of a novel cytosolic NADP(H)-dependent retinol oxidoreductase from rabbit liver
    D Y Huang
    Department of Biochemistry, School of Medicine, Kagawa Medical University, Japan
    Biochim Biophys Acta 1338:47-59. 1997
    ..This enzyme exhibits relatively broad aldehyde reductase activity and some ketone reductase activity, the activity for aromatic substitutive aldehydes being ..
  42. ncbi Biosynthesis of podophyllotoxin in Linum album cell cultures
    Veronique Seidel
    Natural Products Research, Faculty of Applied Sciences, De Montfort University, The Gateway, Leicester LEI 9BH, UK
    Planta 215:1031-9. 2002
    ..Electronic supplementary material to this paper can be obtained by using the Springer LINK server located at http://dx.doi.org/wo.1007/s00425-002-0834-1...
  43. ncbi Cloning and expression of two novel aldo-keto reductases from Digitalis purpurea leaves
    Isabel Gavidia
    Center of Plant Molecular Biology ZMBP, University of Tubingen, Germany
    Eur J Biochem 269:2842-50. 2002
    ..proteins present high identities (68-80%) with four Arabidopsis clones and a 67% identity with the aldose/aldehyde reductase from Medicago sativa...
  44. doi Escherichia coli YqhD exhibits aldehyde reductase activity and protects from the harmful effect of lipid peroxidation-derived aldehydes
    Jose Manuel Perez
    Laboratorio de Microbiologia Molecular, Departamento de Biologia, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Santiago 9170019, Chile
    J Biol Chem 283:7346-53. 2008
    ..We speculate that in Escherichia coli YqhD is part of a glutathione-independent, NADPH-dependent response mechanism to lipid peroxidation...
  45. pmc Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog
    K Watanabe
    Hayaishi Bioinformation Transfer Project, Kyoto Laboratory, Research Development Corporation of Japan
    Proc Natl Acad Sci U S A 85:11-5. 1988
    ..that bovine lung PGF synthase shows 62% identical plus conservative substitutions compared with human liver aldehyde reductase [Wermuth, B., Omar, A., Forster, A., Francesco, C., Wolf, M., Wartburg, J.P., Bullock, B. & Gabbay, K.H...
  46. ncbi Metyrapone reductase purified partially from liver microsomes of male rats: the enzyme differs from acetohexamide reductase
    Y Imamura
    Faculty of Pharmaceutical Sciences, Kumamoto University, Japan
    Res Commun Mol Pathol Pharmacol 96:219-26. 1997
    ..The substrate specificities were in fair agreement with those of carbonyl reductase. However, the partially purified enzyme was strongly inhibited by inhibitors of aldehyde reductase, such as barbital, phenobarbital and sodium valproate.
  47. doi Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma
    Yazhou Cui
    Key Laboratory of Ministry of Health for Biotech Drug, Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Jinan, PR China
    Pancreatology 9:89-98. 2009
    ..Dual expression of potential biomarkers in both benign and malignant pancreatic tumors was a major obstacle in the development of diagnostic biomarkers of early pancreatic cancer...
  48. ncbi Aldose reductase from human psoas muscle. Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosine
    N A Morjana
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    J Biol Chem 264:2912-9. 1989
    ..the essential lysine was found to be highly homologous with a segment of the sequence of both human liver aldehyde reductase and rat lens aldose reductase...
  49. ncbi Carbonyl reductases and pluripotent hydroxysteroid dehydrogenases of the short-chain dehydrogenase/reductase superfamily
    Frank Hoffmann
    Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig Holstein, Campus Kiel, Brunswiker Strasse, Kiel, 10, 24105, Germany
    Drug Metab Rev 39:87-144. 2007
    ..Whereas aldehyde reductase and aldose reductase are AKRs, several forms of carbonyl reductase belong to the SDRs...
  50. ncbi Molecular cloning and expression of rat liver 3 alpha-hydroxysteroid dehydrogenase
    K C Cheng
    Department of Pediatrics Cornell University Medical College, New York, New York 10021
    Mol Endocrinol 5:823-8. 1991
    ..other enzymes, including bovine prostaglandin F synthase, human chlordecone reductase, human aldose reductase, human aldehyde reductase, and frog lens epsilon-crystalline, suggesting that these proteins belong to the same gene family.
  51. ncbi Developmental expression and function of aldehyde reductase in proximal tubules of the kidney
    Oleg A Barski
    Harry B and Aileen Gordon Diabetes Research Laboratory, Baylor College of Medicine, Houston, Texas, USA
    Am J Physiol Renal Physiol 289:F200-7. 2005
    b>Aldehyde reductase reduces a wide variety of toxic and physiological aldehydes with a marked preference for negatively charged substrates such as glucuronate...
  52. pmc Polyol formation in cell lines of rat retinal capillary pericytes and endothelial cells (TR-rPCT and TR-iBRB)
    Peter F Kador
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
    J Ocul Pharmacol Ther 25:299-308. 2009
    ....
  53. pmc Systematic analysis of the gene expression in the livers of nonalcoholic steatohepatitis: implications on potential biomarkers and molecular pathological mechanism
    Yida Zhang
    Department of Bioinformatics, Tongji University, Shanghai, PR China
    PLoS ONE 7:e51131. 2012
    ..b>Alcohol dehydrogenase 4 (ADH4) exhibited the highest rank suggesting the most significant differential expression between normal ..
  54. ncbi Metabolism of trans, trans-muconaldehyde, a cytotoxic metabolite of benzene, in mouse liver by alcohol dehydrogenase Adh1 and aldehyde reductase AKR1A4
    Duncan M Short
    Department of Bioscience, University of Strathclyde, 204 George Street, Glasgow, G1 1XW Scotland, UK
    Toxicol Appl Pharmacol 210:163-70. 2006
    ..muconaldehyde reductase activity independent of Adh1, and one enzyme was identified as the NADPH-dependent aldehyde reductase AKR1A4. This showed a Vmax of 115 nmol/min/mg and a Km of 15+/-2 microM and was not inhibited by pyrazole.
  55. ncbi Asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate with two co-existing, recombinant Escherichia coli strains
    Ying Liu
    Department of Chemical Engineering and Bioengineering, Institute of Bioengineering, Zhejiang University, Hangzhou, Zhejiang, 310027, P R China
    Biotechnol Lett 27:119-25. 2005
    ..coli M15 (pQE30-gdh0310), which were constructed to express, respectively, an NADPH-dependent aldehyde reductase gene and a glucose dehydrogenase gene, were mixed in an appropriate ratio and used for the asymmetric ..
  56. ncbi Characterization of aldose reductase and aldehyde reductase from the medulla of rat kidney
    M Ohta
    Division of Biological Chemistry and Biologicals, National Institute of Hygienic Sciences, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 38:1639-43. 1990
    Aldose reductase and aldehyde reductase from the medulla of the rat kidney have been purified to homogeneity by using affinity chromatography, gel filtration and chromatofocusing...
  57. doi Structure-activity relations on [1-(3,5-difluoro-4-hydroxyphenyl)-1H-pyrrol-3-yl]phenylmethanone. The effect of methoxy substitution on aldose reductase inhibitory activity and selectivity
    Maria Chatzopoulou
    Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece
    Bioorg Med Chem 19:1426-33. 2011
    ..On this basis, compounds 4b-c and 5a-c were synthesized and assayed for aldose and aldehyde reductase inhibitory activity...
  58. pmc Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions
    Chen Wu
    State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Nat Genet 44:1090-7. 2012
    ..Our results underscore the direct genetic contribution to ESCC risk, as well as the genetic contribution to ESCC through interaction with alcohol consumption...
  59. ncbi Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3
    Andrei Molotkov
    Gene Regulation Program, Burnham Institute, La Jolla, CA 92037, USA
    Eur J Biochem 269:2607-12. 2002
    ..Here, Adh1, Adh3, and Adh4 null mutant mice have been examined following acute and chronic vitamin A excess...
  60. doi X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity
    Francesc Xavier Ruiz
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Chem Biol Interact 202:178-85. 2013
    ..with its low in vivo side effects, was highly selective for aldose reductase (AR or AKR1B1) versus aldehyde reductase (AKR1A1)...
  61. ncbi Genetic polymorphisms of ADH2, ADH3, CYP4502E1 Dra-I and Pst-I, and ALDH2 in Spanish men: lack of association with alcoholism and alcoholic liver disease
    Francesc Vidal
    Department of Internal Medicine, Hospital Universitari de Tarragona Joan XXIII, C Dr Mallafré Guasch, 4, 43007 Tarragona, Spain
    J Hepatol 41:744-50. 2004
    ....
  62. ncbi Growth hormone (GH) action in the developing lung: changes in lung proteins after adenoviral GH overexpression
    Jason A Beyea
    Department of Physiology and Perinatal Research Centre, University of Alberta, Edmonton, Alberta, Canada
    Dev Dyn 234:404-12. 2005
    ..enzymes (nucleotide diphosphate kinase B, Cu/Zn superoxide dismutase, glutathione-S-transferase, and aldehyde reductase-1) were increased by the adenoviral expression of mouse GH, as were the concentrations of beta subunit G-..
  63. ncbi Adhesion of Aureobasidium pullulans is controlled by uronic acid based polymers and pullulan
    Jill M Pouliot
    Department of Chemical Engineering, Worcester Polytechnic Institute, Worcester, Massachusetts 01609, USA
    Biomacromolecules 6:1122-31. 2005
    ..33 +/-2.01 nN; alpha = 0.43). Steric interactions alone do not describe the adhesion behavior of this fungus, but they do provide information regarding the length and density of the macromolecules studied...
  64. ncbi Human class IV alcohol dehydrogenase: kinetic mechanism, functional roles and medical relevance
    Shih Jiun Yin
    Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, ROC
    Chem Biol Interact 143:219-27. 2003
    Human alcohol dehydrogenase (ADH) constitutes a complex family. Class IV ADH (ADH4) is characteristic in its epithelial expression in the aerodigestive tract and high V(max) and K(m) for oxidation of ethanol...
  65. doi Effect of C7 modifications on benzothiadiazine-1,1-dioxide derivatives on their inhibitory activity and selectivity toward aldose reductase
    Shuzhen Zhang
    Department of Applied Chemistry, Beijing Institute of Technology, Zhongguancun South Street, 100081 Beijing, China
    ChemMedChem 8:603-13. 2013
    ..respectively, were found to be the most active and presented excellent selectivity for ALR2 over aldehyde reductase (ALR1)...
  66. doi YNL134C from Saccharomyces cerevisiae encodes a novel protein with aldehyde reductase activity for detoxification of furfural derived from lignocellulosic biomass
    Xianxian Zhao
    Institute of Ecological and Environmental Sciences, College of Resources and Environmental Sciences, Sichuan Agricultural University, Wenjiang, Sichuan, People s Republic of China
    Yeast 32:409-22. 2015
    ..Enzyme activity assays showed that YNL134C is an NADH-dependent aldehyde reductase, which plays a role in detoxification of furfural to FM...
  67. ncbi Relationship between genetic polymorphisms of alcohol-metabolizing enzymes and changes in risk factors for coronary heart disease associated with alcohol consumption
    Yoshiaki Hashimoto
    Departments of Clinical Laboratory Medicine, University of Tokyo Hospital, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Clin Chem 48:1043-8. 2002
    ....
  68. ncbi Inhibition of alcohol dehydrogenase after 2-propanol exposure in different geographic races of Drosophila mojavensis: lack of evidence for selection at the Adh-2 locus
    Edward Pfeiler
    Centro de Investigacion en Alimentacion y Desarrollo, A C, Unidad Guaymas, Apartado Postal 284, Guaymas, Sonora 85480, Mexico
    J Exp Zool B Mol Dev Evol 304:159-68. 2005
    ..ADH-1 activity in female ovaries was inhibited less by 2-propanol than ADH-2. These results do not support the hypothesis that 2-propanol acts as a selective factor favoring the Adh-2F allele...
  69. doi Associations between ADH gene variants and alcohol phenotypes in Dutch adults
    Jenny H D A van Beek
    Department of Biological Psychology, VU University Amsterdam, Amsterdam, The Netherlands
    Twin Res Hum Genet 13:30-42. 2010
    ..SNPs in the ADH gene cluster located on chromosome 4q (n = 491) were subdivided in seven gene sets: ADH5, ADH4, ADH6, ADH1A, ADH1B, ADH1C and ADH7...
  70. pmc Cloning and sequencing of a processed pseudogene derived from a human class III alcohol dehydrogenase gene
    Y Matsuo
    Department of Ecology, Ethology, and Evolution, University of Illinois, Urbana Champaign 61820
    Am J Hum Genet 46:85-91. 1990
    ..been classified into five previously known loci: ADH1 (18 clones), ADH2 (20 clones), and ADH3 class I (16 clones), ADH4 class II (4 clones), and ADH5 class III (1 clone)...
  71. pmc Toward aldehyde and alkane production by removing aldehyde reductase activity in Escherichia coli
    Gabriel M Rodriguez
    Department of Chemistry, University of California, Davis, One Shields Avenue, Davis, CA 95616, USA
    Metab Eng 25:227-37. 2014
    ..Elucidation of the ALRs found in E. coli could guide one in reducing competing alcohol formation during alkane or aldehyde production. ..
  72. ncbi Molecular phylogeny and divergence times of drosophilid species
    C A Russo
    Institute of Molecular Evolutionary Genetics, Pennsylvania State University, University Park 16802, USA
    Mol Biol Evol 12:391-404. 1995
    ..melanogaster groups apparently diverged about 25 Mya. Many of the D. repleta group species studied here have two functional Adh genes (Adh-1 and Adh-2), and these duplicated genes can be explained by two duplication events...
  73. pmc Regulatory elements involved in Drosophila Adh gene expression are conserved in divergent species and separate elements mediate expression in different tissues
    J A Fischer
    EMBO J 5:1275-89. 1986
    ....
  74. pmc Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3
    Sridevi Bodreddigari
    Department of Biology and W Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, Tennessee 38152, USA
    Chem Res Toxicol 21:1134-42. 2008
    ..B 1 (AFB 1) dialdehyde metabolite to its corresponding mono and dialcohols, catalyzed by aflatoxin B 1-aldehyde reductase (AFAR, rat AKR7A1, and human AKR7A3), is greatly increased in livers of rats treated with numerous ..
  75. doi Direct enzyme assay evidence confirms aldehyde reductase function of Ydr541cp and Ygl039wp from Saccharomyces cerevisiae
    Jaewoong Moon
    Bioenergy Research Unit, National Center for Agricultural Utilization Research, USDA ARS, Peoria, IL, USA
    Yeast 32:399-407. 2015
    The aldehyde reductase gene ARI1 is a recently characterized member of an intermediate subfamily within the short-chain dehydrogenase/reductase (SDR) superfamily that clarified mechanisms of in situ detoxification of 2-furaldehyde and 5-..
  76. doi Inhibition of human alcohol and aldehyde dehydrogenases by aspirin and salicylate: Assessment of the effects on first-pass metabolism of ethanol
    Shou Lun Lee
    Department of Biological Science and Technology, China Medical University, 91 Hsueh Shih Road, Taichung 40402, Taiwan Electronic address
    Biochem Pharmacol 95:71-9. 2015
    ..salicylate of ethanol oxidation by recombinant human ADH1A, ADH1B1, ADH1B2, ADH1B3, ADH1C1, ADH1C2, ADH2, and ADH4, and acetaldehyde oxidation by ALDH1A1 and ALDH2, at pH 7.5 and 0.5mM NAD(+)...
  77. doi Correlation of binding constants and molecular modelling of inhibitors in the active sites of aldose reductase and aldehyde reductase
    Vincenzo Carbone
    Medicinal Chemistry and Drug Action, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia
    Bioorg Med Chem 17:1244-50. 2009
    ..and correlate inhibitor potency and binding energies of the complexes with ALR2 and the homologous aldehyde reductase (ALR1), another member of the AKR superfamily...
  78. pmc A non-synonymous variant in ADH1B is strongly associated with prenatal alcohol use in a European sample of pregnant women
    Luisa Zuccolo
    Department of Social Medicine, University of Bristol, Bristol, UK
    Hum Mol Genet 18:4457-66. 2009
    ..We confirmed the established association of rs1229984 with reduced alcohol consumption over the life-course, contributing new evidence of an effect before and during pregnancy...
  79. ncbi Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin
    J D Hayes
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom
    Cancer Res 53:3887-94. 1993
    ..Therefore, this inducible enzyme has been designated aflatoxin B1-aldehyde reductase (AFB1-AR)...
  80. ncbi Aldose and aldehyde reductases from human kidney cortex and medulla
    B Robinson
    Department of Biochemstry, University of New Mexico School of Medicine, Albuquerque 87131
    Biochim Biophys Acta 1203:260-6. 1993
    Aldose reductase and aldehyde reductase were purified to homogeneity from multiple samples of human kidney cortex and medulla...
  81. ncbi High and complementary expression patterns of alcohol and aldehyde dehydrogenases in the gastrointestinal tract: implications for Parkinson's disease
    Marie Westerlund
    Department of Neuroscience, Karolinska Institutet, 171 77 Stockholm, Sweden
    FEBS J 274:1212-23. 2007
    ..involvement of alcohol and aldehyde dehydrogenases (ADH; ALDH) by identifying genetic variants in ADH1C and ADH4 that associate with PD...
  82. pmc Hominids adapted to metabolize ethanol long before human-directed fermentation
    Matthew A Carrigan
    Department of Natural Sciences, Santa Fe College, Gainesville, FL 32606 Foundation for Applied Molecular Evolution, Gainesville, FL 32604 and
    Proc Natl Acad Sci U S A 112:458-63. 2015
    ..Here, we resurrect digestive alcohol dehydrogenases (ADH4) from our primate ancestors to explore the history of primate-ethanol interactions...
  83. pmc Metabolism of Nω -methylserotonin, a serotonergic constituent of black cohosh (Cimicifuga racemosa, L. (Nutt.)), by human liver microsomes
    Dejan Nikolic
    Department of Medicinal Chemistry and Pharmacognosy, UIC NIH Center for Botanical Dietary Supplements Research, College of Pharmacy, University of Illinois at Chicago, 833 S Wood St, Chicago, IL, 60612 7231, USA
    Biomed Chromatogr 28:1647-51. 2014
    ..acid by the action of microsomal aldehyde dehydrogenase or reduced to 5-hydroxy tryptophol by the action of aldehyde reductase. The cytochrome P450 enzymes had only a minor role in the metabolism of Nω -methylserotonin and then only ..
  84. doi Effect of pentachlorophenol and 2,6-dichloro-4-nitrophenol on the activity of cDNA-expressed human alcohol and aldehyde dehydrogenases
    Ronny Kollock
    German Institute of Human Nutrition DIfE Potsdam Rehbruecke, Department of Nutritional Toxicology, 14558 Nuthetal, Germany
    Toxicol Lett 191:360-4. 2009
    ..4 microM, K(i)' 5.2 microM, mixed-type) and ADH2 (K(i) 3.7 microM, competitive), but moderate for ADH4 (K(i) 81 microM, competitive) and ADH1C (K(i)' 310 microM, uncompetitive)...
  85. pmc Similarity of Escherichia coli propanediol oxidoreductase (fucO product) and an unusual alcohol dehydrogenase from Zymomonas mobilis and Saccharomyces cerevisiae
    T Conway
    School of Biological Sciences, University of Nebraska, Lincoln 68588 0118
    J Bacteriol 171:3754-9. 1989
    ..7% identity with the iron-containing alcohol dehydrogenase II from Zymomonas mobilis and 39.5% identity with ADH4 from Saccharomyces cerevisiae...
  86. ncbi Characterization of a microsomal retinol dehydrogenase gene from amphioxus: retinoid metabolism before vertebrates
    D Dalfo
    Departament de Genetica, Facultat de Biologia, Universitat de Barcelona, Av Diagonal, 645, E 08028, Barcelona, Spain
    Chem Biol Interact 130:359-70. 2001
    ..Nevertheless, recent data show that the vertebrate-ADH1 and ADH4 retinol-active forms originated after the divergence of cephalochordates and vertebrates...
  87. doi Identification of hepatic biomarkers for physiological imbalance of dairy cows in early and mid lactation using proteomic technology
    K M Moyes
    Department of Animal Sciences, Faculty of Science and Technology, Aarhus University, DK 8830 Tjele, Denmark
    J Dairy Sci 96:3599-610. 2013
    ..Despite the small sample size (n=3/group), the results lay a foundation for future research focused on the usefulness of the hepatic biomarkers for predicting PI and thereby cows at risk for disease during lactation...
  88. ncbi In vitro inhibition of lens aldose reductase by (2-benzyl-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indole-8-yl)-acetic acid in enzyme preparations isolated from diabetic rats
    P O Djoubissie
    Institute of Experimental Pharmacology, Slovak Academy of Sciences, Dubravska cesta 9, 84104 Bratislava 4, Slovakia
    Gen Physiol Biophys 25:415-25. 2006
    ..In testing for selectivity, comparisons to rat kidney aldehyde reductase, an enzyme with the highest homology to aldose reductase, was used...
  89. pmc Cloning, overexpression, and mutagenesis of the Sporobolomyces salmonicolor AKU4429 gene encoding a new aldehyde reductase, which catalyzes the stereoselective reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (S)-4-chloro-3-hydroxybutanoate
    K Kita
    Department of Biotechnology, Tottori University, 4 101 Koyama, Tottori 680 8552, Japan
    Appl Environ Microbiol 65:5207-11. 1999
    We cloned and sequenced the gene encoding an NADPH-dependent aldehyde reductase (ARII) in Sporobolomyces salmonicolor AKU4429, which reduces ethyl 4-chloro-3-oxobutanoate (4-COBE) to ethyl (S)-4-chloro-3-hydroxybutanoate...
  90. ncbi Characterization and cofactor binding mechanism of a novel NAD(P)H-dependent aldehyde reductase from Klebsiella pneumoniae DSM2026
    Cheng Wei Ma
    School of Life Science and Biotechnology, Dalian University of Technology, Dalian 116024, China
    J Microbiol Biotechnol 23:1699-707. 2013
    ..In this paper, the yqhD gene from Klebsiella pneumoniae DSM2026, which was found encoding an aldehyde reductase (KpAR), was cloned and characterized...
  91. pmc Large-scale reverse genetics in Arabidopsis: case studies from the Chloroplast 2010 Project
    Imad Ajjawi
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Physiol 152:529-40. 2010
    ..fatty acid desaturation phenotypes associated with mutants of At1g10310, previously described as a pterin aldehyde reductase in folate metabolism...
  92. ncbi The NADP-linked aldehyde reductase from Trypanosoma cruzi: subcellular localization and some properties
    S Arauzo
    Instituto de Investigaciones Bioquimicas Fundacion Campomar, Buenos Aires, Argentina
    FEMS Microbiol Lett 49:283-6. 1989
    NADP-linked aldehyde reductase (AR; EC 1.1.1...
  93. ncbi Polymorphism of the human alcohol dehydrogenase 4 (ADH4) promoter affects gene expression
    H J Edenberg
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202 5122, USA
    Pharmacogenetics 9:25-30. 1999
    The human alcohol dehydrogenase 4 gene (ADH4) encodes the human pi-alcohol dehydrogenase (pi-ADH), which can contribute to ethanol metabolism at moderate and high concentrations of ethanol...
  94. doi Inhibition of aldose reductase by dietary antioxidant curcumin: mechanism of inhibition, specificity and significance
    P Muthenna
    Biochemistry Division, National Institute of Nutrition, Hyderabad 500 604, India
    FEBS Lett 583:3637-42. 2009
    ..but is a poor inhibitor of closely-related members of the aldo-keto reductase superfamily, particularly aldehyde reductase. Results from molecular docking studies are consistent with the pattern of inhibition of ALR2 by curcumin ..
  95. ncbi The structure and function of yeast xylose (aldose) reductases
    H Lee
    University of Guelph, Department of Environmental Biology, Ontario, Canada
    Yeast 14:977-84. 1998
    ..sequences of yeast xylose reductases with the much better characterized human aldose reductase and human aldehyde reductase reveals that the yeast enzymes are hybrids between aldo-keto reductases and the short chain dehydrogenases/..
  96. ncbi In vivo glycation of aldehyde reductase, a major 3-deoxyglucosone reducing enzyme: identification of glycation sites
    M Takahashi
    Department of Biochemistry, Osaka University Medical School, Japan
    Biochemistry 34:1433-8. 1995
    ..3-DG), a major intermediate and a potent cross-linker in the Maillard reaction, is identical with aldehyde reductase [Takahashi, M., Fujii, J., Teshima, T., Suzuki, K., Shiba, T., & Taniguchi, N. (1993) Gene 127, 249-253]...
  97. pmc Production of medium chain length fatty alcohols from glucose in Escherichia coli
    J Tyler Youngquist
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, 3629 Engineering Hall, 1415 Engineering Drive, Madison, WI 53706, United States Great Lakes Bioenergy Research Center, University of Wisconsin Madison, Madison, WI 53706, United States
    Metab Eng 20:177-86. 2013
    ..1-dodecanol and 1-tetradecanol, an acyl-ACP thioesterase (BTE), an acyl-CoA ligase (FadD), and an acyl-CoA/aldehyde reductase (MAACR) were overexpressed in an engineered strain of Escherichia coli...
  98. ncbi Competing roles of cytochrome P450 1A1/1B1 and aldo-keto reductase 1A1 in the metabolic activation of (+/-)-7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene in human bronchoalveolar cell extracts
    Hao Jiang
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    Chem Res Toxicol 18:365-74. 2005
    ..TCDD) to express P450 1A1/P450 1B1 or by stable transfection to express AKR1A1 (aldehyde reductase). TCDD induction of AKR1A1 transfectants provided a cell line that expressed both pathways...
  99. ncbi Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity
    Ossama El-Kabbani
    Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University Parkville Campus, 381 Royal Parade, VIC 3052, Australia Ossama El Kabbani vcp monash edu au
    J Med Chem 48:5536-42. 2005
    Structure determination of porcine aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat was carried out to explain the difference in the potency of the inhibitor for aldose and aldehyde reductases...
  100. ncbi Efficient production of recombinant aldehyde reductase and its application for asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate
    Keju Jing
    Institute of Bioengineering, Department of Chemical Engineering and Bioengineering, Zhejiang University, Hangzhou, PR China
    Prep Biochem Biotechnol 35:203-15. 2005
    An NADPH-dependent aldehyde reductase (ALR, EC1.1.1.2) gene is cloned from Sporobolomyces salmonicolor ZJUB 105, and inserted into plasmid pQE30 to construct the expression plasmid (pQE30-ALR). A variety of E...
  101. ncbi Multiplicity of mammalian reductases for xenobiotic carbonyl compounds
    Toshiyuki Matsunaga
    Laboratory of Biochemistry, Gifu Pharmaceutical University, Japan
    Drug Metab Pharmacokinet 21:1-18. 2006
    ..member 4, 11beta-hydroxysteroid dehydrogenase type 1, L-xylulose reductase, two types of aflatoxin B1 aldehyde reductase, 20alpha-hydroxysteroid dehydrogenase, and three types of 3alpha-hydroxysteroid dehydrogenase...

Research Grants30

  1. Protein Modification by 3,4-Dihydroxyphenylacetaldehyde
    JONATHAN DOORN; Fiscal Year: 2006
    ..metabolized primarily to an acid via mitochondrial aldehyde dehydrogenase (ALDH2) but also to an alcohol by aldehyde reductase (ALR). Recent work implicates oxidative stress and lipid peroxidation products, e.g...
  2. ALDO-KETO REDUCTASES AS PART OF CHEMICAL STRESS RESPONSE
    Oleg Barski; Fiscal Year: 2002
    ..Recently it was shown that ethoxyquin and antiobiotic tunicamycin also induce aldehyde reductase, another member of the aldo-keto reductase family...
  3. STRUCTURAL IDENTIFICATION OF PROSTAGLANDIN CONJUGATES
    L Roberts; Fiscal Year: 2000
    ..The ability of PGF-synthase and liver aldehyde reductase to reduce IsoP endoperoxides to F-ring IsoP's will also be examined...
  4. Molecular Mechanisms of Multistage Carcinogenesis
    TREVOR PENNING; Fiscal Year: 2006
    ..Project # 1 (Dr. Penning) will compare the roles of human aldehyde reductase (AKR1A1), CYP1A1/CYP1B1, and CYP-peroxidase in the metabolic activation of PAH using a stable expression ..
  5. ALCOHOL METABOLISM GENES IN TRANSGENIC MICE
    Michael Felder; Fiscal Year: 2007
    ..alcohol-induced liver damage Distal cis-linked sequence in a BAC clone will direct expression of Adh1 in liver and Adh4 in stomach No sequence directing liver expression of any human class I ADH gene is known...
  6. STRUCTURE & EXPRESSION OF MAMMAL ALC DEHYDROGENASE GENES
    Howard Edenberg; Fiscal Year: 2000
    ..The ADH4, ADH5, ADH6 and ADH7 genes have different patterns of expression, and produce enzymes (PI-ADH, X-ADH, ADH6 and ..
  7. Animal Model to Study Retinoic Acid Function in Postnatal and Adult Tissues
    GREGG L DUESTER; Fiscal Year: 2012
    ..e. retinol dehydrogenase-10 (RDH10) and two alcohol dehydrogenases (ADH3 and ADH4)...
  8. Enzyme & Receptor Antagonists of GHB, GBL & 1, 4-BD
    Lawrence Quang; Fiscal Year: 2003
    ..The results of this study will expand upon promising data from pilot studies performed in this laboratory on acute 1,4-BD and GHB toxicity as well as novel therapeutic agents for its potential medical management. ..
  9. Diet, gene-diet interactions and risk of Parkinson's
    Honglei Chen; Fiscal Year: 2004
    ..NHS cohorts, he will evaluate the associations of PD risk with common polymorphisms of NAT2, CYP1A2, ADH2, ADH3, ADH4, and MTHFR...
  10. Alcohol in Israel: Genetic and Environmental Effects
    Deborah Hasin; Fiscal Year: 2007
    ..ADH3 and promoters of ADH4 and ALDH2 will also be studied. Psychiatric comorbidity, religiosity and trauma will be assessed and controlled...
  11. Retinoid Dehydrogenases Involved in Eye Development
    GREGG L DUESTER; Fiscal Year: 2010
    ....
  12. GENETIC DISSECTION OF ALCOHOL/RETINOL METABOLIC PATHWAYS
    Gregg Duester; Fiscal Year: 2002
    ..3) Prepare and ALDH-I knockout mouse plus mice mutated for one or more ADHs and ALDH-I, then analyze their phenotype as above. ..
  13. Oxidative Stress, VEGF and Retinopathy
    DAVID VANDER JAGT; Fiscal Year: 2004
    ..It provides a testable model that connects hyperglycemia-> oxidative stress-> growth factors-> diabetic retinopathy. ..
  14. SPECIFICITY AND FUNCTION OF ALCOHOL DEHYDROGENASES
    BRYCE PLAPP; Fiscal Year: 2004
    ....
  15. Dynamic and Catalysis by Alcohol Dehydrogenases
    BRYCE PLAPP; Fiscal Year: 2009
    ..Design of better inhibitors for treating the pathology of alcoholism depends on understanding the dynamics of catalysis by the rate-limiting enzyme in the pathway of alcohol metabolism. ..
  16. Association and Function of Opioid Receptor Gene Variants to Substance Dependence
    Huiping Zhang; Fiscal Year: 2008
    ..Jeffrey Gruen (co-mentor), who are both excellent supervisors with substantial experience in genetic studies of complex disorders and who have both mentored numerous previous trainees. [unreadable] [unreadable] [unreadable]..
  17. Investigating the Molecular Mechanism of Hexose-induced Stress in Lens and Retina
    Peter F Kador; Fiscal Year: 2010
    ..Moreover, these studies should help identify new drug targets for the treatment of these diabetic complications. ..
  18. Fine-mapping the risk loci for alcoholism in ADH gene cluster and ALDH2 gene
    Xingguang Luo; Fiscal Year: 2010
    ..In a word, this study will identify some risk genes for alcohol dependence, helping us better understand the etiology of alcohol dependence and provide potential targets for new drugs. ..
  19. GENETICS OF COCAINE DEPENDENCE
    Joel Gelernter; Fiscal Year: 2010
    ..The project will also contribute to a substantial increase in our understanding of the mechanisms of CD, and may lead to new approaches to the prevention and treatment of this pervasive societal problem. ..
  20. Alcohol Dependence Genetics in a Large Chinese Pedigree
    Joel Gelernter; Fiscal Year: 2008
    ..This study will improve understanding of the genes that influence risk for alcohol dependence, in Chinese populations, and in comparison with European-American populations. [unreadable] [unreadable] [unreadable]..
  21. Alzheimer's Disease Drugs
    DAVID VANDER JAGT; Fiscal Year: 2008
    ..Versatile schemes to synthesize analogs of resveratrol have been developed. The Specific Aim of this proposal is to test resveratrol and analogs in an animal model of Alzheimer's disease. [unreadable] [unreadable] [unreadable]..
  22. RESEARCH TRAINING FOR VETERINARIANS: ANIMAL MODELS
    John Sundberg; Fiscal Year: 2008
    ..The investigators ask to maintain the three slots currently funded. This program is designed to meet the increasing demand for scientists in functional genomics research. ..
  23. Alcohol: Direct and Indirect Effects in Drug Metabolism
    THOMAS BADGER; Fiscal Year: 2008
    ..abstract_text> ..
  24. SPECIES SUSCEPTIBILITY TO DIABETIC COMPLICATIONS
    KENNETH GABBAY; Fiscal Year: 2002
    ....
  25. Alopecia and Ulcerative Dermatitis in B6 Mice
    John Sundberg; Fiscal Year: 2007
    ..B6 mice are naturally hypomorphic for alcohol dehydrogenase 4 (Adh4), which may be involved in detoxifying vitamin A metabolites resulting in these enzyme expression ..
  26. Multifunctional Antioxidants as Anti-Cataract Agents
    Peter Kador; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  27. ALDO/KETO REDUCTASES AND DIABETIC COMPLICATIONS
    KENNETH GABBAY; Fiscal Year: 2001
    DESCRIPTION (Adapted from applicant's abstract): Aldose and aldehyde reductase are closely related members of the aldo-keto reductase superfamily...
  28. PATHOLOGY OF THE LABORATORY MOUSE
    John Sundberg; Fiscal Year: 2006
    ..The Workshop will accommodate 16 participants who will have an opportunity to interact with a group of prominent mouse pathologists and geneticists from both TJL, and other leading institutions. ..
  29. GENETICS OF COCAINE INDUCED PSYCHOSIS
    Joel Gelernter; Fiscal Year: 2003
    ..This program of research will improve our understanding of the genetics underlying human brain responses to chronic cocaine exposure, thus leading to better diagnosis and treatments for cocaine dependence and other addictive disorders. ..
  30. Approaches to the Genetics of Substance Dependence
    Joel Gelernter; Fiscal Year: 2007
    ..This proposal would permit the PI to make a major investment in mentorship, and allow a broadening of his research program in substance dependence. [unreadable] [unreadable] [unreadable] [unreadable]..