ADH4

Summary

Gene Symbol: ADH4
Description: alcohol dehydrogenase 4 (class II), pi polypeptide
Alias: ADH-2, alcohol dehydrogenase 4, alcohol dehydrogenase class II pi chain, aldehyde reductase
Species: human

Top Publications

  1. ncbi ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Pharmacogenet Genomics 15:755-68. 2005
  2. pmc Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
  3. ncbi ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1085-95. 2006
  4. pmc Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample
    Po Hsiu Kuo
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
    Alcohol Clin Exp Res 32:785-95. 2008
  5. pmc Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism
    G Mårdh
    Proc Natl Acad Sci U S A 83:8908-12. 1986
  6. pmc Personality traits of agreeableness and extraversion are associated with ADH4 variation
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:599-608. 2007
  7. ncbi Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients
    Camila Guindalini
    Human Genome Research Center, Department of Biology, Institute of Biosciences, University of Sao Paulo, Rua do Matao, Travessa 13, Number 106, Cidade Universitária CEP 05508 090, Sao Paulo SP, Brazil
    Am J Psychiatry 162:1005-7. 2005
  8. ncbi Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population
    Yehuda D Neumark
    Braun School of Public Health and Community Medicine, Hebrew University of Jerusalem Hadassah, Jerusalem, Israel
    Alcohol Clin Exp Res 28:10-4. 2004
  9. pmc ADH single nucleotide polymorphism associations with alcohol metabolism in vivo
    Andrew J Birley
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Hum Mol Genet 18:1533-42. 2009
  10. ncbi Cutaneous metabolism of glycol ethers
    David J Lockley
    Skin Toxicology Group, Department of Environmental and Occupational Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    Arch Toxicol 79:160-8. 2005

Research Grants

  1. Alcohol-Metabolizing Gene Variation, Lipids, Hemostatic Factors and CVD
    Kelly Volcik; Fiscal Year: 2007
  2. Protein Modification by 3,4-Dihydroxyphenylacetaldehyde
    JONATHAN DOORN; Fiscal Year: 2006
  3. ALCOHOL METABOLISM GENES IN TRANSGENIC MICE
    Michael Felder; Fiscal Year: 2007
  4. ALDO-KETO REDUCTASES AS PART OF CHEMICAL STRESS RESPONSE
    Oleg Barski; Fiscal Year: 2002
  5. CARDIAC METABOLISM OF ENALS
    Aruni Bhatnagar; Fiscal Year: 2009
  6. CARDIAC METABOLISM OF ENALS
    ARUNI BHATNAGAR BHATNAGAR; Fiscal Year: 2010
  7. Molecular Mechanisms of Multistage Carcinogenesis
    TREVOR PENNING; Fiscal Year: 2006
  8. Electrostatics and Dynamics in Proteins
    STEVEN BOXER; Fiscal Year: 2009
  9. Electrostatics and Dynamics in Proteins
    Steven G Boxer; Fiscal Year: 2010
  10. INTRACELLULAR GLYCATION AND DIABETIC COMPLICATIONS
    Michael Brownlee; Fiscal Year: 2000

Detail Information

Publications151 found, 100 shown here

  1. ncbi ADH4 gene variation is associated with alcohol and drug dependence: results from family controlled and population-structured association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Pharmacogenet Genomics 15:755-68. 2005
    We found strong associations between ADH4 gene variation and alcohol and drug dependence by the Hardy-Weinberg Disequilibrium (HWD) test and case-control association analysis in an initial study...
  2. pmc Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
    ..001) between alcohol consumption phenotypes and rs1693482 (ADH1C), rs1230165 (ADH5) and rs3762894 (ADH4)...
  3. ncbi ADH4 gene variation is associated with alcohol dependence and drug dependence in European Americans: results from HWD tests and case-control association studies
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 31:1085-95. 2006
    ..The ADH4 gene, an important member of this family, is a functional and positional candidate for alcohol dependence...
  4. pmc Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample
    Po Hsiu Kuo
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
    Alcohol Clin Exp Res 32:785-95. 2008
    ..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence...
  5. pmc Human class II (pi) alcohol dehydrogenase has a redox-specific function in norepinephrine metabolism
    G Mårdh
    Proc Natl Acad Sci U S A 83:8908-12. 1986
    ..These features and the presence of pi ADH in human liver imply a physiological role for pi ADH in the degradation of circulating epinephrine and norepinephrine...
  6. pmc Personality traits of agreeableness and extraversion are associated with ADH4 variation
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 61:599-608. 2007
    ..Strong associations between ADH4 variation and SD have been reported...
  7. ncbi Association of genetic variants in alcohol dehydrogenase 4 with alcohol dependence in Brazilian patients
    Camila Guindalini
    Human Genome Research Center, Department of Biology, Institute of Biosciences, University of Sao Paulo, Rua do Matao, Travessa 13, Number 106, Cidade Universitária CEP 05508 090, Sao Paulo SP, Brazil
    Am J Psychiatry 162:1005-7. 2005
    The authors evaluated the association of three functional promoter polymorphisms of the ADH4 gene with alcohol dependence.
  8. ncbi Alcohol dehydrogenase polymorphisms influence alcohol-elimination rates in a male Jewish population
    Yehuda D Neumark
    Braun School of Public Health and Community Medicine, Hebrew University of Jerusalem Hadassah, Jerusalem, Israel
    Alcohol Clin Exp Res 28:10-4. 2004
    ..The mechanism by which this allelic effect is mediated is not yet clearly understood. This study examined the effect of ADH2*2 on alcohol-elimination rates (AER) under experimental conditions...
  9. pmc ADH single nucleotide polymorphism associations with alcohol metabolism in vivo
    Andrew J Birley
    Genetic Epidemiology Unit, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    Hum Mol Genet 18:1533-42. 2009
    ..SNPs were associated with the early stages of alcohol metabolism, with additional effects in the ADH1A, ADH1B and ADH4 regions...
  10. ncbi Cutaneous metabolism of glycol ethers
    David J Lockley
    Skin Toxicology Group, Department of Environmental and Occupational Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    Arch Toxicol 79:160-8. 2005
    ..However, ADH1, ADH3 and ADH4 predominate in rat skin, demonstrate different sensitivities to pyrazole, and are responsible for metabolising ..
  11. pmc The intra- and extracellular proteome of Aspergillus niger growing on defined medium with xylose or maltose as carbon substrate
    Xin Lu
    Helmholtz Center for Infection Research, Inhoffenstr, Braunschweig, Germany
    Microb Cell Fact 9:23. 2010
    ..13 growing on defined medium with xylose or maltose as carbon substrate was carried out using 2-D gel electrophoresis/Maldi-ToF and nano-HPLC MS/MS...
  12. pmc Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors
    L I McLellan
    Department of Clinical Biochemistry, University of Edinburgh, Royal Infirmary, U K
    Biochem J 300:117-24. 1994
    ..In addition, the effect of these drugs on the hepatic levels of an aldehyde reductase (AFB1-AR) that metabolizes the cytotoxic dialdehydic form of AFB1 has been studied as this enzyme also ..
  13. ncbi Molecular and metabolic retinoid pathways in the human ocular surface
    Hachemi Nezzar
    Universite d Auvergne, JE 2447, ARDEMO, France
    Mol Vis 13:1641-50. 2007
    ..The second objective was to demonstrate the presence of different enzymes transforming vitamin A to retinoic acid and the functionality of this metabolic pathway in the corneal epithelium...
  14. ncbi Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members
    Teruhiko Iino
    Department of General Studies, Nihon University, Sakurajosui 3 25 40, Setagaya Ku, Tokyo 156 8550, Japan
    Arch Biochem Biophys 416:180-7. 2003
    ..by 3 alpha-hydroxysteroid dehydrogenase type 2, whereas 1(')-OXPH(4) was produced by aldose reductase, aldehyde reductase, and 20 alpha-hydroxysteroid dehydrogenase, and both 1(')-OXPH(4) and 2(')-OXPH(4) were detected as the ..
  15. ncbi Vitamin C. Biosynthesis, recycling and degradation in mammals
    Carole L Linster
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Brussels, Belgium
    FEBS J 274:1-22. 2007
    ..Glucuronate is converted to l-gulonate by aldehyde reductase, an enzyme of the aldo-keto reductase superfamily...
  16. ncbi Inhibition of alcohol dehydrogenase after 2-propanol exposure in different geographic races of Drosophila mojavensis: lack of evidence for selection at the Adh-2 locus
    Edward Pfeiler
    Centro de Investigacion en Alimentacion y Desarrollo, A C, Unidad Guaymas, Apartado Postal 284, Guaymas, Sonora 85480, Mexico
    J Exp Zool B Mol Dev Evol 304:159-68. 2005
    ..ADH-1 activity in female ovaries was inhibited less by 2-propanol than ADH-2. These results do not support the hypothesis that 2-propanol acts as a selective factor favoring the Adh-2F allele...
  17. ncbi Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1
    J D Hayes
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Chem Biol Interact 111:51-67. 1998
    ..In addition to GSTA5, we have identified a novel aflatoxin-aldehyde reductase (AFAR) that is similarly induced by ethoxyquin...
  18. ncbi The role of liver alcohol dehydrogenase isoenzymes in the oxidation of glycolethers in male and female rats
    L Aasmoe
    Department of Clinical Pharmacology, University Hospital, University of Tromsø, Norway
    Toxicol Appl Pharmacol 150:86-90. 1998
    ..However, it was the same ADH isoenzyme (ADH-3) that oxidized the different glycolethers tested in both male and female rat livers, and the substrate specificity was 2-BE > 2-EE > 2-ME...
  19. ncbi Tracing the history of an enzyme polymorphism: the case of alcohol dehydrogenase-2 (Adh-2) of the olive fruit fly Bactrocera oleae
    George N Goulielmos
    Department of Genetics, Agricultural University of Athens, Athens, Greece
    Mol Biol Evol 20:293-306. 2003
    ..The estimated age of the polymorphism is compatible with this hypothesis, but firmer support could be difficult to obtain...
  20. ncbi Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin
    J D Hayes
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom
    Cancer Res 53:3887-94. 1993
    ..Therefore, this inducible enzyme has been designated aflatoxin B1-aldehyde reductase (AFB1-AR)...
  21. ncbi Impaired retinol utilization in Adh4 alcohol dehydrogenase mutant mice
    L Deltour
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    Dev Genet 25:1-10. 1999
    b>Adh4, a member of the mouse alcohol dehydrogenase (ADH) gene family, encodes an enzyme that functions in vitro as a retinol dehydrogenase in the conversion of retinol to retinoic acid, an important developmental signaling molecule...
  22. pmc Distinct retinoid metabolic functions for alcohol dehydrogenase genes Adh1 and Adh4 in protection against vitamin A toxicity or deficiency revealed in double null mutant mice
    Andrei Molotkov
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    J Biol Chem 277:13804-11. 2002
    The ability of class I alcohol dehydrogenase (ADH1) and class IV alcohol dehydrogenase (ADH4) to metabolize retinol to retinoic acid is supported by genetic studies in mice carrying Adh1 or Adh4 gene disruptions...
  23. ncbi ADH4-lacZ transgenic mouse reveals alcohol dehydrogenase localization in embryonic midbrain/hindbrain, otic vesicles, and mesencephalic, trigeminal, facial, and olfactory neural crest
    R J Haselbeck
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    Alcohol Clin Exp Res 22:1607-13. 1998
    ..Herein, we have used transgenic mice to examine the mouse gene encoding class IV ADH (ADH4), an enzyme that is weakly effective as an ethanol dehydrogenase, but highly effective as a retinol dehydrogenase ..
  24. ncbi Rat liver alcohol dehydrogenase of class III. Primary structure, functional consequences and relationships to other alcohol dehydrogenases
    P Julia
    Department of Chemistry I, Karolinska Institutet, Stockholm, Sweden
    Eur J Biochem 172:73-83. 1988
    ..Finally the class III structure supports evolutionary relationships suggesting that the three classes constitute clearly separate enzymes within the group of mammalian zinc-containing alcohol dehydrogenases...
  25. ncbi Human class IV alcohol dehydrogenase: kinetic mechanism, functional roles and medical relevance
    Shih Jiun Yin
    Department of Biochemistry, National Defense Medical Center, Taipei, Taiwan, ROC
    Chem Biol Interact 143:219-27. 2003
    Human alcohol dehydrogenase (ADH) constitutes a complex family. Class IV ADH (ADH4) is characteristic in its epithelial expression in the aerodigestive tract and high V(max) and K(m) for oxidation of ethanol...
  26. ncbi Characterization of the functional gene encoding mouse class III alcohol dehydrogenase (glutathione-dependent formaldehyde dehydrogenase) and an unexpressed processed pseudogene with an intact open reading frame
    M H Foglio
    La Jolla Cancer Foundation Research Foundation, CA 92037, USA
    Eur J Biochem 237:496-504. 1996
    ..Reporter gene expression following transfection into mouse F9 embryonal carcinoma cells indicated that only Adh-2 possesses promoter activity...
  27. ncbi Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3
    Andrei Molotkov
    Gene Regulation Program, Burnham Institute, La Jolla, CA 92037, USA
    Eur J Biochem 269:2607-12. 2002
    ..Here, Adh1, Adh3, and Adh4 null mutant mice have been examined following acute and chronic vitamin A excess...
  28. ncbi Polymorphism of the human alcohol dehydrogenase 4 (ADH4) promoter affects gene expression
    H J Edenberg
    Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis 46202 5122, USA
    Pharmacogenetics 9:25-30. 1999
    The human alcohol dehydrogenase 4 gene (ADH4) encodes the human pi-alcohol dehydrogenase (pi-ADH), which can contribute to ethanol metabolism at moderate and high concentrations of ethanol...
  29. doi The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells
    Jan Vondracek
    Department of Cytokinetics, Institute of Biophysics ASCR, Brno, Czech Republic
    Chem Biol Interact 180:226-37. 2009
    ..In contrast, the aldehyde reductase AKR1A1 was not induced by either treatment...
  30. ncbi Aldose reductase: an aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia
    Minoru Kawamura
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Auton Neurosci 96:131-9. 2002
    ..Although similar formation of DHPG was observed with human liver aldehyde reductase, the production of DHPG was more effective with aldose reductase than aldehyde reductase...
  31. doi Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometry
    Denise N Johnson
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 21:752-60. 2008
    ..This urinary detection of the alcohol products directly contributes to the goal of mass balancing the fate of the bioreactive 8,9-epoxides of AFB 1 in vivo...
  32. ncbi Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter
    Elizabeth M Ellis
    Department of Bioscience and Pharmaceutical Sciences, University of Strathclyde, Glasgow G1 1XW, UK
    Carcinogenesis 24:727-37. 2003
    Rat aflatoxin B(1) aldehyde reductase (called AFAR1 or AKR7A1) is a member of the aldo-keto reductase 7 family, which metabolizes the environmental carcinogen aflatoxin B(1)...
  33. pmc Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins
    Vincent P Kelly
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Biochem J 366:847-61. 2002
    The aldo-keto reductase (AKR) 7 family is composed of the dimeric aflatoxin B(1) aldehyde reductase (AFAR) isoenzymes. In the rat, two AFAR subunits exist, designated rAFAR1 and rAFAR2...
  34. ncbi Aldose reductase in human retinal pigment epithelial cells
    S Sato
    Laboratory of Ocular Therapeutics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
    Exp Eye Res 57:235-41. 1993
    ..In addition to aldose reductase, chromatofocusing demonstrated the presence of aldehyde reductase, another NADPH-dependent reductase...
  35. ncbi Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase
    C J Winters
    Department of Medicine, Medical College of Virginia, Richmond 23298
    Biochemistry 29:1080-7. 1990
    ..The deduced protein sequence of CDR showed 65% similarity to the primary structure of human liver aldehyde reductase and 66% similarity to the inferred protein sequence of rat lens aldose reductase...
  36. ncbi Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity
    W R Lacy
    Department of Cell Biology, Baylor College of Medicine Houston, Texas 77030
    Mol Endocrinol 7:58-66. 1993
    ..to human chlordecone reductase, bovine lung prostaglandin F synthase, human aldose reductase, human aldehyde reductase, and frog lens rho-crystallin, placing rabbit ovarian 20 alpha HSD in the aldo-keto reductase family of ..
  37. ncbi Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells
    C Praml
    Division of Cytogenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Res 58:5014-8. 1998
    ..a gene encoding a protein of 330 amino acids that is 78% identical with the Rattus norvegicus aflatoxin B1 aldehyde reductase (Afar) and, therefore, likely represents its human homologue...
  38. pmc Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities
    Kevork Hagopian
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Biosci Rep 28:107-15. 2008
    ..Aldehyde dehydrogenase and aldehyde reductase activities in both young and old CR mice were unchanged by caloric restriction...
  39. ncbi Enzymes in pancreatic islets that use NADP(H) as a cofactor including evidence for a plasma membrane aldehyde reductase
    M Laclau
    University of Wisconsin Childrens Diabetes Center, Madison, USA
    Mol Cell Biochem 225:151-60. 2001
    ..Significant activities of glutathione reductase, aldose reductase (EC.1.1.1.21) and aldehyde reductase (EC.1.1.1.2) were present in islets...
  40. ncbi Purification and characterization of human testis aldose and aldehyde reductase
    T Tanimoto
    Division of Biological Chemistry, National Institute of Hygienic Sciences, Tokyo, Japan
    Int J Biochem 23:421-8. 1991
    1. Aldose reductase and aldehyde reductase were purified to homogeneity from human testis. 2...
  41. ncbi Alcohol dehydrogenases in Xenopus development: conserved expression of ADH1 and ADH4 in epithelial retinoid target tissues
    I Hoffmann
    Gene Regulation Program, Burnham Institute, La Jolla, California 92037, USA
    Dev Dyn 213:261-70. 1998
    Mammalian alcohol dehydrogenases ADH1 (class I ADH) and ADH4 (class IV ADH) function as retinol dehydrogenases contributing to the synthesis of retinoic acid, the active form of vitamin A involved in growth and development...
  42. pmc Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3
    Sridevi Bodreddigari
    Department of Biology and W Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, Tennessee 38152, USA
    Chem Res Toxicol 21:1134-42. 2008
    ..B 1 (AFB 1) dialdehyde metabolite to its corresponding mono and dialcohols, catalyzed by aflatoxin B 1-aldehyde reductase (AFAR, rat AKR7A1, and human AKR7A3), is greatly increased in livers of rats treated with numerous ..
  43. ncbi Characterization of the serotoninergic system in the C57BL/6 mouse skin
    Andrzej Slominski
    Department of Pathology, University of Tennessee Health Science Center, Memphis, TN, USA
    Eur J Biochem 270:3335-44. 2003
    ..acid, probably through stepwise transformation catalyzed by monoamine oxidase, aldehyde dehydrogenase and aldehyde reductase. Activity of the melatonin-forming enzyme hydroxyindole-O-methyltransferase was notably below detectable ..
  44. ncbi Isolation of a set of genes expressed in the choroid plexus of the mouse using suppression subtractive hybridization
    N Matsumoto
    Department of Anatomy and Neurobiology, Kyoto University Graduate School of Medicine, Yoshida konoe cho, Sakyo ku, Kyoto 606 8501, Japan
    Neuroscience 117:405-15. 2003
    ..gelsolin, phospholipid transfer protein, ATP-binding cassette transporter A8 (ABCA8), androgen-inducible aldehyde reductase, and Na(+)/sulfate cotransporter SUT-1...
  45. pmc Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat
    Bill D Roebuck
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Toxicol Sci 109:41-9. 2009
    ..These results imply that the prevention of protein adducts mediated by AKR are not critical to protection against AFB(1) tumorigenicity...
  46. pmc A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant
    D J Judah
    MRC Toxicology Unit, Carshalton, Surrey, U K
    Biochem J 292:13-8. 1993
    In contrast with fractions from control animals, an aldehyde reductase, which catalyses the reduction of aflatoxin B1-dihydrodiol, in the dialdehyde form at physiological pH values, to aflatoxin B1-dialcohol, is expressed in cytosolic ..
  47. ncbi Biosynthesis of podophyllotoxin in Linum album cell cultures
    Veronique Seidel
    Natural Products Research, Faculty of Applied Sciences, De Montfort University, The Gateway, Leicester LEI 9BH, UK
    Planta 215:1031-9. 2002
    ..Electronic supplementary material to this paper can be obtained by using the Springer LINK server located at http://dx.doi.org/wo.1007/s00425-002-0834-1...
  48. ncbi Purification and characterization of a novel cytosolic NADP(H)-dependent retinol oxidoreductase from rabbit liver
    D Y Huang
    Department of Biochemistry, School of Medicine, Kagawa Medical University, Japan
    Biochim Biophys Acta 1338:47-59. 1997
    ..This enzyme exhibits relatively broad aldehyde reductase activity and some ketone reductase activity, the activity for aromatic substitutive aldehydes being ..
  49. doi Escherichia coli YqhD exhibits aldehyde reductase activity and protects from the harmful effect of lipid peroxidation-derived aldehydes
    Jose Manuel Perez
    Laboratorio de Microbiologia Molecular, Departamento de Biologia, Facultad de Quimica y Biologia, Universidad de Santiago de Chile, Santiago 9170019, Chile
    J Biol Chem 283:7346-53. 2008
    ..We speculate that in Escherichia coli YqhD is part of a glutathione-independent, NADPH-dependent response mechanism to lipid peroxidation...
  50. ncbi Cloning and expression of two novel aldo-keto reductases from Digitalis purpurea leaves
    Isabel Gavidia
    Center of Plant Molecular Biology ZMBP, University of Tubingen, Germany
    Eur J Biochem 269:2842-50. 2002
    ..proteins present high identities (68-80%) with four Arabidopsis clones and a 67% identity with the aldose/aldehyde reductase from Medicago sativa...
  51. pmc Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog
    K Watanabe
    Hayaishi Bioinformation Transfer Project, Kyoto Laboratory, Research Development Corporation of Japan
    Proc Natl Acad Sci U S A 85:11-5. 1988
    ..that bovine lung PGF synthase shows 62% identical plus conservative substitutions compared with human liver aldehyde reductase [Wermuth, B., Omar, A., Forster, A., Francesco, C., Wolf, M., Wartburg, J.P., Bullock, B. & Gabbay, K.H...
  52. doi Proteomic analysis of pancreatic ductal adenocarcinoma compared with normal adjacent pancreatic tissue and pancreatic benign cystadenoma
    Yazhou Cui
    Key Laboratory of Ministry of Health for Biotech Drug, Shandong Medicinal Biotechnology Center, Shandong Academy of Medical Sciences, Jinan, PR China
    Pancreatology 9:89-98. 2009
    ..Dual expression of potential biomarkers in both benign and malignant pancreatic tumors was a major obstacle in the development of diagnostic biomarkers of early pancreatic cancer...
  53. ncbi Carbonyl reductases and pluripotent hydroxysteroid dehydrogenases of the short-chain dehydrogenase/reductase superfamily
    Frank Hoffmann
    Institute of Toxicology and Pharmacology for Natural Scientists, University Medical School Schleswig Holstein, Campus Kiel, Brunswiker Strasse, Kiel, 10, 24105, Germany
    Drug Metab Rev 39:87-144. 2007
    ..Whereas aldehyde reductase and aldose reductase are AKRs, several forms of carbonyl reductase belong to the SDRs...
  54. ncbi Metyrapone reductase purified partially from liver microsomes of male rats: the enzyme differs from acetohexamide reductase
    Y Imamura
    Faculty of Pharmaceutical Sciences, Kumamoto University, Japan
    Res Commun Mol Pathol Pharmacol 96:219-26. 1997
    ..The substrate specificities were in fair agreement with those of carbonyl reductase. However, the partially purified enzyme was strongly inhibited by inhibitors of aldehyde reductase, such as barbital, phenobarbital and sodium valproate.
  55. ncbi Aldose reductase from human psoas muscle. Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosine
    N A Morjana
    Department of Biochemistry, Queen s University, Kingston, Ontario, Canada
    J Biol Chem 264:2912-9. 1989
    ..the essential lysine was found to be highly homologous with a segment of the sequence of both human liver aldehyde reductase and rat lens aldose reductase...
  56. ncbi Molecular cloning and expression of rat liver 3 alpha-hydroxysteroid dehydrogenase
    K C Cheng
    Department of Pediatrics Cornell University Medical College, New York, New York 10021
    Mol Endocrinol 5:823-8. 1991
    ..other enzymes, including bovine prostaglandin F synthase, human chlordecone reductase, human aldose reductase, human aldehyde reductase, and frog lens epsilon-crystalline, suggesting that these proteins belong to the same gene family.
  57. ncbi Developmental expression and function of aldehyde reductase in proximal tubules of the kidney
    Oleg A Barski
    Harry B and Aileen Gordon Diabetes Research Laboratory, Baylor College of Medicine, Houston, Texas, USA
    Am J Physiol Renal Physiol 289:F200-7. 2005
    b>Aldehyde reductase reduces a wide variety of toxic and physiological aldehydes with a marked preference for negatively charged substrates such as glucuronate...
  58. pmc Polyol formation in cell lines of rat retinal capillary pericytes and endothelial cells (TR-rPCT and TR-iBRB)
    Peter F Kador
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, 986025 Nebraska Medical Center, Omaha, NE 68198 6025, USA
    J Ocul Pharmacol Ther 25:299-308. 2009
    ....
  59. pmc Production of medium chain length fatty alcohols from glucose in Escherichia coli
    J Tyler Youngquist
    Department of Chemical and Biological Engineering, University of Wisconsin Madison, 3629 Engineering Hall, 1415 Engineering Drive, Madison, WI 53706, United States Great Lakes Bioenergy Research Center, University of Wisconsin Madison, Madison, WI 53706, United States
    Metab Eng 20:177-86. 2013
    ..1-dodecanol and 1-tetradecanol, an acyl-ACP thioesterase (BTE), an acyl-CoA ligase (FadD), and an acyl-CoA/aldehyde reductase (MAACR) were overexpressed in an engineered strain of Escherichia coli...
  60. ncbi Aldehyde reductase isozymes in the mouse: evidence for two new loci and localization of Ahr-3 on chromosome 7
    P B Mather
    Biochem Genet 23:483-96. 1985
    Evidence is presented for two new forms of mouse liver and kidney aldehyde reductase activity (designated AHR-3 and AHR-4) resolved using cellulose acetate electrophoresis zymogram techniques and stained by glyceraldehyde and NADPH as ..
  61. ncbi Purification and properties of an NADPH-dependent carbonyl reductase from human brain. Relationship to prostaglandin 9-ketoreductase and xenobiotic ketone reductase
    B Wermuth
    J Biol Chem 256:1206-13. 1981
    A nonspecific NADPH-dependent carbonyl reductase from human brain (formerly designated as aldehyde reductase 1; Ris, M. M., and von Wartburg, J. P. (1973) Eur. J. Biochem. 37, 69-77) has been purified to homogeneity...
  62. ncbi Competing roles of cytochrome P450 1A1/1B1 and aldo-keto reductase 1A1 in the metabolic activation of (+/-)-7,8-dihydroxy-7,8-dihydro-benzo[a]pyrene in human bronchoalveolar cell extracts
    Hao Jiang
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6084, USA
    Chem Res Toxicol 18:365-74. 2005
    ..TCDD) to express P450 1A1/P450 1B1 or by stable transfection to express AKR1A1 (aldehyde reductase). TCDD induction of AKR1A1 transfectants provided a cell line that expressed both pathways...
  63. ncbi Multiplicity of mammalian reductases for xenobiotic carbonyl compounds
    Toshiyuki Matsunaga
    Laboratory of Biochemistry, Gifu Pharmaceutical University, Japan
    Drug Metab Pharmacokinet 21:1-18. 2006
    ..member 4, 11beta-hydroxysteroid dehydrogenase type 1, L-xylulose reductase, two types of aflatoxin B1 aldehyde reductase, 20alpha-hydroxysteroid dehydrogenase, and three types of 3alpha-hydroxysteroid dehydrogenase...
  64. ncbi Gene regulation of aldose-, aldehyde- and a renal specific oxido reductase (RSOR) in the pathobiology of diabetes mellitus
    Farhad R Danesh
    Departments of Pathology and Medicine, Northwestern University Medical School, Chicago, Illinois, USA
    Curr Med Chem 10:1399-406. 2003
    ..During the past three decades aldehyde reductase (AKR1A) and aldose reductase (AKR1B) have been extensively investigated, and the gene regulation of AKR1B ..
  65. ncbi Efficient production of recombinant aldehyde reductase and its application for asymmetric reduction of ethyl 4-chloro-3-oxobutanoate to ethyl (R)-4-chloro-3-hydroxybutanoate
    Keju Jing
    Institute of Bioengineering, Department of Chemical Engineering and Bioengineering, Zhejiang University, Hangzhou, PR China
    Prep Biochem Biotechnol 35:203-15. 2005
    An NADPH-dependent aldehyde reductase (ALR, EC1.1.1.2) gene is cloned from Sporobolomyces salmonicolor ZJUB 105, and inserted into plasmid pQE30 to construct the expression plasmid (pQE30-ALR). A variety of E...
  66. ncbi Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity
    Ossama El-Kabbani
    Department of Medicinal Chemistry, Victorian College of Pharmacy, Monash University Parkville Campus, 381 Royal Parade, VIC 3052, Australia Ossama El Kabbani vcp monash edu au
    J Med Chem 48:5536-42. 2005
    Structure determination of porcine aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat was carried out to explain the difference in the potency of the inhibitor for aldose and aldehyde reductases...
  67. doi Association of VMAT2 gene polymorphisms with alcohol dependence
    Christoph Fehr
    Department of Psychiatry and Psychotherapy, University of Mainz, Untere Zahlbacher Str 8, 55131, Mainz, Germany
    J Neural Transm 120:1161-9. 2013
    ..Few candidate genes have been identified, comprising ADH4, ALDH2, COMT, CRHR1, DAT (SLC6A3), GABRA2 and MAOA...
  68. pmc Effect of alcohol and aldehyde dehydrogenase gene polymorphisms on alcohol-associated hypertension: the Guangzhou Biobank Cohort Study
    Wei Sen Zhang
    Molecular Epidemiological Research Centre, Guangzhou No 12 Hospital, Guangzhou, China
    Hypertens Res 36:741-6. 2013
    ..ADH2 genotype influences blood pressure and risk of hypertension among male alcohol drinkers, suggesting that the hypertensive effect of alcohol is due to ethanol rather than acetaldehyde. ..
  69. ncbi Transamination in the metabolism of the nephrotoxicant N-(3,5-dichlorophenyl)succinimide in rats
    Donghui Cui
    Department of Pharmaceutical Sciences, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, 600 South 43 Street, Philadelphia, PA 19104 4495, USA
    Drug Metab Dispos 33:1765-70. 2005
    ..Results from these studies show that transamination is a metabolic pathway in the clearance of NDPS in rats, and that cytosolic dehydrogenases and aminotransferases may be involved in this process...
  70. doi Molecular cloning of rat liver 3α-hydroxysteroid dehydrogenase and identification of structurally related proteins from rat lung and kidney
    K C Cheng
    Department of Pediatrics, Cornell University Medical College, New York, NY 10021, USA
    J Steroid Biochem Mol Biol 43:1083-8. 1992
    ..such as bovine prostaglandin F synthase, human chlordecone reductase, human aldose reductase, human aldehyde reductase and frog lens epsilon-crystallin, suggesting that these proteins belong to the same gene family...
  71. pmc High-resolution structure of AKR1a4 in the apo form and its interaction with ligands
    Frédérick Faucher
    Department of Biomedical and Molecular Sciences, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Acta Crystallogr Sect F Struct Biol Cryst Commun 68:1271-4. 2012
    Aldo-keto reductase 1a4 (AKR1a4; EC 1.1.1.2) is the mouse orthologue of human aldehyde reductase (AKR1a1), the founding member of the AKR family. As an NADPH-dependent enzyme, AKR1a4 catalyses the conversion of D-glucuronate to L-gulonate...
  72. pmc Comparative proteomics of skeletal muscle mitochondria from myostatin-null mice
    Jonathan Puddick
    Department of Biological Sciences, Faculty of Science and Engineering, The University of Waikato, Private Bag 3105, Hamilton, New Zealand
    Cell Biol Int Rep (2010) 18:e00013. 2011
    ..This protein, having a sequence similar to that of aldehyde reductase, was up-regulated in myostatin-null mitochondria, but its importance was not established, although it might ..
  73. doi Influence of broccoli extract and various essential oils on performance and expression of xenobiotic- and antioxidant enzymes in broiler chickens
    Kristin Mueller
    Institute of Agricultural and Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Br J Nutr 108:588-602. 2012
    ..SFN, Cuo and Ro increased the expression of xenobiotic enzymes (epoxide hydrolases 1 and 2 and aflatoxin B1 aldehyde reductase) and of the antioxidant enzyme haeme oxygenase regulated by an 'antioxidant response element' (ARE) compared ..
  74. doi Benzo(a)pyrene induces hepatic AKR1A1 mRNA expression in tilapia fish (Oreochromis niloticus)
    Citlalli Osorio-Yáñez
    Departamento de Toxicologia, Centro de Investigacion y de Estudios Avanzados del IPN, San Pedro Zacatenco, Mexico City, Mexico
    Toxicol Mech Methods 22:438-44. 2012
    AKR1A1 or aldehyde reductase is a member of the aldo-keto reductases superfamily that is evolutionarily conserved among species...
  75. pmc Glyoxylate metabolism is a key feature of the metabolic degradation of 1,4-dioxane by Pseudonocardia dioxanivorans strain CB1190
    Ariel Grostern
    Department of Civil and Environmental Engineering, University of California, Berkeley, Berkeley, California, USA
    Appl Environ Microbiol 78:3298-308. 2012
    ..Plasmid-borne genes for putative aldehyde dehydrogenases, an aldehyde reductase, and an alcohol oxidoreductase were also induced during growth with dioxane...
  76. pmc Differential protein expression in honeybee (Apis mellifera L.) larvae: underlying caste differentiation
    Jianke Li
    Key Laboratory of Pollinating Insect Biology, Department of Beekeeping and Biotechnology, Ministry of Agriculture, Institute of Apicultural Research, Chinese Academy of Agricultural Science, Beijing, China
    PLoS ONE 5:e13455. 2010
    ..Specifically, at 72 hours, queen intended larvae over-expressed transketolase, aldehyde reductase, and enolase proteins which are involved in carbohydrate metabolism and energy production, imaginal disc ..
  77. doi Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features
    Holger Steuber
    Department of Pharmaceutical Chemistry, Philipps University Marburg, Marbacher Weg 6, 35032 Marburg, Germany
    J Mol Biol 379:991-1016. 2008
    ..bioavailability, putative inhibitors should possess a high level of selectivity for ALR2 over the related aldehyde reductase (ALR1)...
  78. doi Proteomics of cauda epididymal fluid from mature Holstein bulls
    Arlindo A Moura
    Department of Animal Science, Federal University of Ceara, Brazil
    J Proteomics 73:2006-20. 2010
    ..N-acetyl-β-glucosaminidase, cauxin, glutathione peroxidase, acidic seminal fluid protein (aSFP), aldehyde reductase, α-l-fucosidase, α-1-β-glycoprotein, apolipoprotein A-1, β actin, calmodulin, cathepsin D, cystatin E/M, ..
  79. doi Tissue expression pattern of class II and class V genes found in the Adh complex on mouse chromosome 3
    Gabor Szalai
    Department of Biological Sciences, University of South Carolina, Columbia, SC 29208, USA
    Biochem Genet 46:685-95. 2008
    ..The expression patterns at the mRNA level of the mouse Adh4 (class II) gene and the recently identified Adh6a and Adh6b genes (class V) are now reported to complete this ..
  80. pmc Medium- and short-chain dehydrogenase/reductase gene and protein families : Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolism
    X Pares
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Cell Mol Life Sci 65:3936-49. 2008
    ..ADH1 and ADH2 are the major MDR enzymes in liver retinol detoxification, while ADH3 (less active) and ADH4 (most active) participate in RA generation in tissues...
  81. doi Salivary amylase induction by tannin-enriched diets as a possible countermeasure against tannins
    G da Costa
    ITQB Instituto de Tecnologia Química e Biológica, Oeiras, Portugal
    J Chem Ecol 34:376-87. 2008
    ..One isoform of alpha-amylase was overexpressed with both types of tannins. Aldehyde reductase was only identified in saliva of the quebracho group...
  82. pmc Transcriptional activation of the aldehyde reductase YqhD by YqhC and its implication in glyoxal metabolism of Escherichia coli K-12
    Changhan Lee
    Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Yuseong Gu, Daejeon, Republic of Korea
    J Bacteriol 192:4205-14. 2010
    ..Therefore, we propose that YqhC is a transcriptional activator of YqhD, which acts as an aldehyde reductase with specificity for certain aldehydes, including GO.
  83. doi Discovery of [3-(4,5,7-trifluoro-benzothiazol-2-ylmethyl)-pyrrolo[2,3-b]pyridin-1-yl]acetic acids as highly potent and selective inhibitors of aldose reductase for treatment of chronic diabetic complications
    Michael C Van Zandt
    The Institute for Diabetes Discovery, LLC, 23 Business Park Drive, Branford, CT 06405, USA
    Bioorg Med Chem Lett 19:2006-8. 2009
    ..acid example 16, inhibits aldose reductase with an IC50 of 8 nM, while being inactive against aldehyde reductase (IC50>100 microM), a related enzyme involved in the detoxification of reactive aldehydes.
  84. ncbi Prevalidation of potential protein biomarkers in toxicology using iTRAQ reagent technology
    Matthias Glückmann
    Applied Biosystems, Mass Spectrometry and Proteomics, Darmstadt, Germany
    Proteomics 7:1564-74. 2007
    ..g. placental form of glutathione S-transferase (GST-P), carbonic anhydrase, and aflatoxin B1 aldehyde reductase. Our results show both the usefulness of iTRAQ reagent technology for biomarker prevalidation as well as for ..
  85. doi Mammalian alcohol dehydrogenases--a comparative investigation at gene and protein levels
    Jan Olov Höög
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden
    Chem Biol Interact 191:2-7. 2011
    ..The transcriptional order for the ADH genes in all mammalian genomes is the same (ADH4-ADH1-ADH6-ADH5-ADH2-ADH3), but the cluster is found on different chromosomes in different species...
  86. doi A root proteomics-based insight reveals dynamic regulation of root proteins under progressive drought stress and recovery in Vigna radiata (L.) Wilczek
    Debashree Sengupta
    Photosynthesis and Plant Stress Biology Laboratory, Department of Plant Sciences, School of Life Sciences, University of Hyderabad, Hyderabad 500046, India
    Planta 233:1111-27. 2011
    ..Oxidative stress-related proteins including Cu/Zn superoxide dismutase, oxidoreductase and aldehyde reductase were also up-regulated...
  87. pmc A common telomeric gene silencing assay is affected by nucleotide metabolism
    Marlies P Rossmann
    Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA
    Mol Cell 42:127-36. 2011
    ..imbalance in ribonucleotide reductase (RNR), which is induced by 5-FOA, and the specific promoter of URA3 fused to ADH4 at telomere VII-L are jointly responsible for the variegated phenotype...
  88. pmc Xenobiotic-Metabolizing gene polymorphisms and ovarian cancer risk
    Ellen L Goode
    Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    Mol Carcinog 50:397-402. 2011
    ..956 of serous sub-type) and controls (N = 2046) from three studies were genotyped at 11 SNPs in EPHX1, ADH4, ADH1A, NQO2, NAT2, GSTP1, CYP1A1, and NQO1, following an initial SNP screen in a subset of participants...
  89. pmc Association of alcohol dehydrogenase genes with alcohol-related phenotypes in a Native American community sample
    Ian R Gizer
    Department of Psychological Sciences, University of Missouri, Columbia, Missouri, USA
    Alcohol Clin Exp Res 35:2008-18. 2011
    ....
  90. ncbi Age-related changes in activity of enzymes catalyzing oxidation-reduction of endogenous aldehydes in the liver of rats during immobilization stress
    V V Davydov
    Laboratory of Age Specific Endocrinology and Metabolism, Institute of Child and Adolescent Health Protection, Academy of Medical Sciences, Kharkov
    Bull Exp Biol Med 141:17-9. 2006
    Activities of aldehyde dehydrogenase and aldehyde reductase in the liver 1.5-, 12-, and 24-month-old rats were measured after 30-min immobilization...
  91. pmc Solid-phase translation and RNA-protein fusion: a novel approach for folding quality control and direct immobilization of proteins using anchored mRNA
    Manish Biyani
    Rational Evolutionary Design of Advanced Biomolecules, Saitama Small Enterprise Promotion Corporation SKIP City, 3 12 18 Kamiaoki, Kawaguchi, Saitama 333 0844, Japan
    Nucleic Acids Res 34:e140. 2006
    ..production of immobilized green fluorescent protein (GFP) on microbeads and by the production and assay of aldehyde reductase (ALR) enzyme with 4-fold or more activity...
  92. ncbi [Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome]
    Elzbieta Grochans
    Samodzielna Pracownia Propedeutyki Pielegniarstwa PUM w Szczecinie
    Psychiatr Pol 45:325-35. 2011
    ..Alcohol abuse is a complex multifactorial disease. It is believed that alcohol dependence is mostly caused by genetic (40-50%) and environmental (50-60%) factors...
  93. ncbi Proteomic changes of PC12 cells treated with proteasomal inhibitor PSI
    Lei Zhang
    Department of Neurology, The First Hospital, Jilin University, Changchun 130021, China
    Brain Res 1153:196-203. 2007
    ..glucose-regulated protein (GRP94), heat shock 70 kDa protein 5 (GRP78), heat shock 27 kDa protein 1 (Hsp27), aldehyde reductase 1 (aldose reductase), p47 protein and beta-galactoside-binding lectin (galectin-1)...
  94. ncbi Activity variation in alcohol dehydrogenase paralogs is associated with adaptation to cactus host use in cactophilic Drosophila
    Luciano M Matzkin
    Department of Ecology and Evolution, State University of New York at Stony Brook, Stony Brook, New York 11794 5245, USA
    Mol Ecol 14:2223-31. 2005
    ..Both functional and sequence variation within and between paralogs suggests that Adh has played an important role in the adaptation of D. mojavensis and D. arizonae to their cactophilic life...
  95. pmc Substrate specificity of an aflatoxin-metabolizing aldehyde reductase
    E M Ellis
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, U K
    Biochem J 312:535-41. 1995
    ..Determination of the apparent Km reveals that AFAR has highest affinity for 9,10-phenanthrenequinone and succinic semialdehyde, and low affinity for glyoxal and DL-glyceraldehyde...
  96. ncbi A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography
    M Oka
    Rational Drug Design Laboratories, 4 1 1, Misato, Matsukawa machi, Fukushima 960 1242, Japan
    J Med Chem 43:2479-83. 2000
    ..group of fidarestat was a very effective substituent for affinity to AR and for selectivity between AR and aldehyde reductase (AHR)...
  97. pmc Identification of genes expressed in the amygdala during the formation of fear memory
    O Stork
    Laboratory of Neurochemistry, National Institute for Physiological Sciences, Okazaki 444 8585, Japan
    Learn Mem 8:209-19. 2001
    ..In particular, a key enzyme of monoamine metabolism, aldehyde reductase, and the protein sorting and ubiquitination factor Praja1, showed pronounced and learning-specific induction ..
  98. ncbi Role of extrahepatic alcohol dehydrogenase in rat ethanol metabolism
    M D Boleda
    Department de Bioquimica i Biologia Molecular, Facultat de Ciencies, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Arch Biochem Biophys 274:74-81. 1989
    ..4 microM) and indicate that at the usual concentration of inhibitor only ADH-3 activity will be effectively suppressed. ADH-1 will be, therefore, responsible in part for the residual ethanol oxidation activity in pyrazole-treated rats...
  99. ncbi The Drosophila alcohol dehydrogenase gene may have evolved independently of the functionally homologous medfly, olive fly, and flesh fly genes
    S Brogna
    Institute of Molecular Biology and Biotechnology, Research Center of Crete, Foundation for Research and Technology, Heraklion, Crete, Greece
    Mol Biol Evol 18:322-9. 2001
    ..To explain this unexpected finding, it is proposed that the ADH: genes of the family Drosophilidae may not be orthologous to the ADH: genes of the other two families, Tephritidae and Sarcophagidae...
  100. ncbi Enzymatic conversion of prostaglandin H2 to prostaglandin F2 alpha by aldehyde reductase from human liver: comparison to the prostaglandin F synthetase from bovine lung
    H Hayashi
    Hayaishi Bioinformation Transfer Project, Research Development Corporation of Japan
    J Biol Chem 264:1036-40. 1989
    ..structure of prostaglandin (PG) F synthetase from bovine lung shows 62% similarity with that of human liver aldehyde reductase (EC 1.1.1.2) (Watanabe, K., Fujii, Y., Nakayama, K., Ohkubo, H., Kuramitsu, S., Kagamiyama, H., Nakanishi, S...
  101. ncbi Androgen-regulated expression of a novel member of the aldo-keto reductase superfamily in regrowing rat prostate
    N Nishi
    Department of Endocrinology, Faculty of Medicine, Kagawa Medical University, Japan
    Endocrinology 141:3194-9. 2000
    ..the former a new member of the rat aldo-keto reductase superfamily that is closely related to aflatoxin, B1 aldehyde reductase has been identified...

Research Grants67

  1. Alcohol-Metabolizing Gene Variation, Lipids, Hemostatic Factors and CVD
    Kelly Volcik; Fiscal Year: 2007
    ..sixteen functional and/or non-synonymous variants in the class I and II alcohol dehydrogenase genes (ADH1B, ADH1C, ADH4), the aldehyde dehydrogenase genes (ALDH1, ALDH2) and the cytochrome P4502E1 gene (CYP2E1), all of which are ..
  2. Protein Modification by 3,4-Dihydroxyphenylacetaldehyde
    JONATHAN DOORN; Fiscal Year: 2006
    ..metabolized primarily to an acid via mitochondrial aldehyde dehydrogenase (ALDH2) but also to an alcohol by aldehyde reductase (ALR). Recent work implicates oxidative stress and lipid peroxidation products, e.g...
  3. ALCOHOL METABOLISM GENES IN TRANSGENIC MICE
    Michael Felder; Fiscal Year: 2007
    ..alcohol-induced liver damage Distal cis-linked sequence in a BAC clone will direct expression of Adh1 in liver and Adh4 in stomach No sequence directing liver expression of any human class I ADH gene is known...
  4. ALDO-KETO REDUCTASES AS PART OF CHEMICAL STRESS RESPONSE
    Oleg Barski; Fiscal Year: 2002
    ..Recently it was shown that ethoxyquin and antiobiotic tunicamycin also induce aldehyde reductase, another member of the aldo-keto reductase family...
  5. CARDIAC METABOLISM OF ENALS
    Aruni Bhatnagar; Fiscal Year: 2009
    ..Our studies show that in the heart enals are metabolized by aldose reductase (AR), aldehyde reductase, and glutathione-S-transferases...
  6. CARDIAC METABOLISM OF ENALS
    ARUNI BHATNAGAR BHATNAGAR; Fiscal Year: 2010
    ..Our studies show that in the heart enals are metabolized by aldose reductase (AR), aldehyde reductase, and glutathione-S-transferases...
  7. Molecular Mechanisms of Multistage Carcinogenesis
    TREVOR PENNING; Fiscal Year: 2006
    ..Project # 1 (Dr. Penning) will compare the roles of human aldehyde reductase (AKR1A1), CYP1A1/CYP1B1, and CYP-peroxidase in the metabolic activation of PAH using a stable expression ..
  8. Electrostatics and Dynamics in Proteins
    STEVEN BOXER; Fiscal Year: 2009
    ..probe time-averaged and time-dependent electric fields in several enzymes: human aldose reductase and human aldehyde reductase (Sub-Aim 1A), both important to the control of diabetes, and ketosteroid isomerase (Sub-Aim 1B)...
  9. Electrostatics and Dynamics in Proteins
    Steven G Boxer; Fiscal Year: 2010
    ..probe time-averaged and time-dependent electric fields in several enzymes: human aldose reductase and human aldehyde reductase (Sub-Aim 1A), both important to the control of diabetes, and ketosteroid isomerase (Sub-Aim 1B)...
  10. INTRACELLULAR GLYCATION AND DIABETIC COMPLICATIONS
    Michael Brownlee; Fiscal Year: 2000
    ..The activities of aldehyde reductase, aldose reductase, dihydrodiol dehydrogenase and glyoxalase I will be assessed in primary Muller cells...
  11. ALDOSE REDUCTASE AND DIABETIC COMPLICATIONS
    SATISH SRIVASTAVA; Fiscal Year: 1993
    ..In addition, all the ARIs presently known inhibit both AR and aldehyde reductase, and both enzymes have overlapping substrate specificities...
  12. Vibrational Stark Effect in Human Aldose Reductase
    LAUREN WEBB; Fiscal Year: 2007
    ..One key to finding strong inhibitors of hALR2 that do not also bind to a structurally similar protein, human aldehyde reductase (hALR1), is to measure the electrostatic field of the inhibitor binding site...
  13. Enzyme & Receptor Antagonists of GHB, GBL & 1, 4-BD
    Lawrence Quang; Fiscal Year: 2003
    ..The results of this study will expand upon promising data from pilot studies performed in this laboratory on acute 1,4-BD and GHB toxicity as well as novel therapeutic agents for its potential medical management. ..
  14. Alopecia and Ulcerative Dermatitis in B6 Mice
    John Sundberg; Fiscal Year: 2007
    ..B6 mice are naturally hypomorphic for alcohol dehydrogenase 4 (Adh4), which may be involved in detoxifying vitamin A metabolites resulting in these enzyme expression ..
  15. Diet, gene-diet interactions and risk of Parkinson's
    Honglei Chen; Fiscal Year: 2004
    ..NHS cohorts, he will evaluate the associations of PD risk with common polymorphisms of NAT2, CYP1A2, ADH2, ADH3, ADH4, and MTHFR...
  16. Alcohol in Israel: Genetic and Environmental Effects
    Deborah Hasin; Fiscal Year: 2007
    ..ADH3 and promoters of ADH4 and ALDH2 will also be studied. Psychiatric comorbidity, religiosity and trauma will be assessed and controlled...
  17. ALDO/KETO REDUCTASES AND DIABETIC COMPLICATIONS
    KENNETH GABBAY; Fiscal Year: 2001
    DESCRIPTION (Adapted from applicant's abstract): Aldose and aldehyde reductase are closely related members of the aldo-keto reductase superfamily...
  18. GENETIC DISSECTION OF ALCOHOL/RETINOL METABOLIC PATHWAYS
    Gregg Duester; Fiscal Year: 2002
    ..3) Prepare and ALDH-I knockout mouse plus mice mutated for one or more ADHs and ALDH-I, then analyze their phenotype as above. ..
  19. Generation of Retinoid Signals during Development
    Gregg Duester; Fiscal Year: 2005
    ..Also, we will identify the novel RA-generating enzymes expressed in the neural tube and heart and begin genetic studies on them. ..