Genomes and Genes
Gene Symbol: ADH1C
Description: alcohol dehydrogenase 1C (class I), gamma polypeptide
Alias: ADH3, ADH, gamma subunit, alcohol dehydrogenase 1C, alcohol dehydrogenase 3 (class I), gamma polypeptide, aldehyde reductase
Publications192 found, 100 shown here
- A mapping study of 13 genes on human chromosome bands 4q11-->q25C S Chen
Department of Laboratory Medicine Pathology, University of Minnesota, Minneapolis 55455, USA
Cytogenet Cell Genet 69:260-5. 1995..The alcohol dehydrogenase, class I (ADH2, ADH3) gene cluster can be linked to the alcohol dehydrogenase, class III gene (ADH5) by SacII, NruI, and EagI digests...
- Aldose reductase in human retinal pigment epithelial cellsS Sato
Laboratory of Ocular Therapeutics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
Exp Eye Res 57:235-41. 1993..In addition to aldose reductase, chromatofocusing demonstrated the presence of aldehyde reductase, another NADPH-dependent reductase...
- Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxinR McLeod
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom
Cancer Res 57:4257-66. 1997..The elevation in hepatic AFB1-aldehyde reductase (AFAR) activity in selenium-deficient animals is accompanied by an increase of 11- and 15-fold in the levels ..
- Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genesJanne Schurmann Tolstrup
Center for Alcohol Research, National Institute of Public Health, Copenhagen, Denmark
Pharmacogenomics J 8:220-7. 2008..dehydrogenase (ADH) wherein genetic variation that affects the rate of alcohol degradation is found in ADH1B and ADH1C. It is biologically plausible that these variations may be associated with alcohol drinking habits and alcoholism...
- Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) samplePo Hsiu Kuo
Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
Alcohol Clin Exp Res 32:785-95. 2008..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence...
- Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysisStuart Macgregor
Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Hum Mol Genet 18:580-93. 2009..7 x 10(-5)) and suggestive associations (P<0.001) between alcohol consumption phenotypes and rs1693482 (ADH1C), rs1230165 (ADH5) and rs3762894 (ADH4)...
- Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central EuropeP Soucek
National Institute of Public Health, Prague, Czech Republic
Neoplasma 57:415-21. 2010..metabolizing smoke constituents and/or alcohol (CYP2A13, CYP1B1, EPHX1, NQO1, GSTM1, GSTP1, GSTT1, ADH1B and ADH1C)...
- Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of dietKaren Curtin
Department of Internal Medicine, University of Utah Health Sciences Center, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
Carcinogenesis 28:1672-9. 2007..methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), dihydrofolate reductase (DHFR) and alcohol dehydrogenase 3 (ADH3) were evaluated. CIMP- or CIMP+ phenotype was based on five CpG island markers: MINT1, MINT2, MINT31, p16 and MLH1...
- Genome-wide significant association between alcohol dependence and a variant in the ADH gene clusterJosef Frank
Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Germany
Addict Biol 17:171-80. 2012..The single nucleotide polymorphism (SNP) rs1789891, which is located between the ADH1B and ADH1C genes, achieved genome-wide significance [P = 1.27E-8, odds ratio (OR) = 1.46]...
- Polymorphisms in alcohol metabolizing genes and the risk of head and neck cancer in a Brazilian populationSilvia Marçal Nunes Garcia
Department of Legal Medicine, Bioethics and Occupational Health, School of Medicine, Sao Paulo, SP, Brazil
Alcohol Alcohol 45:6-12. 2010..The aim of this study was to evaluate the association of polymorphisms in genes of alcohol metabolism enzymes and the risk of HNC...
- Alcohol dehydrogenase 3 genotype as a risk factor for upper aerodigestive tract cancersInes Nobuko Nishimoto
Department of Head and Neck Surgery and Otorhinolaryngology, Centro de Tratamento e Pesquisa Hospital do Cancer A C Camargo, Sao Paulo, Brazil
Arch Otolaryngol Head Neck Surg 130:78-82. 2004To assess alcohol dehydrogenase 3 (ADH3) polymorphism at position Ile349Val as indicator of risk factor for upper aerodigestive tract (UADT) cancer to verify its association with UADT cancer in nonalcoholic or nonsmoking individuals.
- Genetic polymorphisms in alcohol metabolism, alcohol intake and the risk of stomach cancer in Warsaw, PolandFang Fang Zhang
Department of Epidemiology, School of Public Health, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
Int J Cancer 121:2060-4. 2007..in alcohol metabolizing genes, including ADH1B (Ex9+5C>T, Ex3+23A>G, Ex3+58A>T and Ex9+77A>G), ADH1C (Ex8-56A>G and Ex6-14G>A) and ALDH2 (Ex1+82A>G), on levels of alcohol drinking and susceptibility of ..
- Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinomaTakahiro Asakage
Department of Otorlaryngology, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
Carcinogenesis 28:865-74. 2007..polymorphisms of aldehyde dehydrogenase-2 (ALDH2), alcohol dehydrogenase-1B (ADH1B, previously called ADH2), and ADH1C (previously called ADH3) affect the metabolism of alcohol...
- Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancerElise M J van der Logt
Department of Gastroenterology, University Medical Centre, St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
Mutat Res 593:39-49. 2006..hydrolase (EPHX1), NAD(P)H:quinone oxidoreductase (NQO1), cytochrome P450 2E1 (CYP2E1) and alcohol dehydrogenase (ADH3) predispose to the development of CRC...
- Risk of head and neck cancer and the alcohol dehydrogenase 3 genotypeA F Olshan
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7400, USA
Carcinogenesis 22:57-61. 2001..The joint effects of lifetime alcohol use and the presence of the ADH3 'rapid' allele (ADH3(*)1) was evaluated in relation to the risk of SCCHN...
- Alcohol dehydrogenase 3 genotype is not associated with risk of squamous cell carcinoma of the oral cavity and pharynxE M Sturgis
Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
Cancer Epidemiol Biomarkers Prev 10:273-5. 2001..To test this hypothesis, we investigated the association between the ADH3 genotype and oral and pharyngeal cancer risk in a large racially homogeneous case-control study of 229 patients and ..
- Interaction between a single nucleotide polymorphism in the alcohol dehydrogenase 3 gene, alcohol consumption and oral cancer riskAthanasios I Zavras
Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, MA, USA
Int J Cancer 97:526-30. 2002..cancer (OC) risk of an interaction between a single nucleotide polymorphism (SNP) in the alcohol dehydrogenase 3 (ADH3) gene and alcohol consumption levels using a hospital-based study of 93 cases and 99 controls conducted in Athens, ..
- Alcohol dehydrogenase genetic polymorphisms, low-to-moderate alcohol consumption, and risk of breast cancerKala Visvanathan
Department of Epidemiology, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
Alcohol Clin Exp Res 31:467-76. 2007In vitro, human isoenzymes encoded by genes homozygous for the ADH1C*1 or ADH1B*2 alleles metabolize ethanol to acetaldehyde at a faster rate than those homozygous for the ADH1C*2 or ADH1B*1 allele...
- Oral squamous cell cancer risk in relation to alcohol consumption and alcohol dehydrogenase-3 genotypesS M Schwartz
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109 1024, USA
Cancer Epidemiol Biomarkers Prev 10:1137-44. 2001..Alcohol dehydrogenase 3 (ADH3) converts ethanol to acetaldehyde, which is a suspected oral carcinogen...
- Variability in ethanol biodisposition in whites is modulated by polymorphisms in the ADH1B and ADH1C genesCarmen Martinez
Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain
Hepatology 51:491-500. 2010..and acoustic signals, and we analyzed 13 single nucleotide polymorphism (SNPs) in the genes coding for ADH1B, ADH1C, ALDH2, and CYP2E1 in 250 healthy white individuals...
- ADH3 genotype, alcohol intake and breast cancer riskMary Beth Terry
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA, and Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
Carcinogenesis 27:840-7. 2006..Individuals differ in their ADH genotype, and one locus in particular (ADH3) is polymorphic in Caucasian populations...
- Frequencies of ADH1C alleles and genotypes in a Turkish head and neck cancer populationS Kortunay
Department of Pharmacology, Faculty of Medicine, Pamukkale University, Denizli, Turkey
Methods Find Exp Clin Pharmacol 32:187-91. 2010..The genomic DNA was isolated from peripheral blood leukocytes. The ADH1C*1 wild-type and ADH1C*2 variant alleles were analyzed with an RFLP method by using SspI as restriction enzyme...
- Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomasMary Beth Terry
Mailman School of Public Health, Department of Epidemiology, Columbia University, 722 West 168th Street, Room 724A, New York, NY 10032, USA
Cancer Causes Control 18:1039-46. 2007..The alcohol dehydrogenase gene has several polymorphisms which may lead to faster conversion of ethanol to acetaldehyde, which may increase cancer risk...
- Risk factors in alcohol associated breast cancer: alcohol dehydrogenase polymorphism and estrogensC Coutelle
Department of Medicine and Laboratory of Alcohol Research, Liver Disease and Nutrition, Salem Medical Centre, Heidelberg, Germany
Int J Oncol 25:1127-32. 2004..acetaldehyde is a carcinogenic factor associated with chronic alcohol consumption, individuals with the alcohol dehydrogenase 1C*1 allele (ADH1C*1 allele) seem to be at particular risk, since this allele encodes for a rapidly ethanol ..
- Alcohol dehydrogenase and aldehyde dehydrogenase polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer StudyGuang Yin
Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Cancer Sci 98:1248-53. 2007..The present case-control study was conducted to determine the influence of ADH2, ADH3 and ALDH2 polymorphisms in Fukuoka, Japan, with 685 incident cases of histologically confirmed colorectal ..
- Lung cancer in humans is not associated with lifetime total alcohol consumption or with genetic variation in alcohol dehydrogenase 3 (ADH3)Jo L Freudenheim
Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, State University of New York, Buffalo, NY 14260, USA
J Nutr 133:3619-24. 2003..In addition we examined the alcohol dehydrogenase 3 (ADH3) genotype in relation to lung cancer risk; ADH3 is rate limiting in alcohol metabolism and has a functional ..
- Polymorphism in ADH and MTHFR genes in oral squamous cell carcinoma of IndiansP R Solomon
Department of Biochemistry, Centre for Advanced Studies in Functional Genomics, School of Biological Sciences, Madurai Kamaraj University, Madurai, India
Oral Dis 14:633-9. 2008..Therefore, this study is designed to asses the polymorphic status in ADH1B (formerly ADH2), ADH1C (formerly ADH3) and MTHFR genes in order to correlate the susceptibility to oral squamous cell carcinoma (OSCC).
- Alcohol dehydrogenase type 3 (ADH3) and the risk of bladder cancerB Van Dijk
Department of Urology, University Medical Centre, Nijmegen, The Netherlands
Eur Urol 40:509-14. 2001..Objectives of this pilot study are to determine whether this polymorphism may be related to bladder cancer and whether it modifies the relation between alcohol intake and bladder cancer...
- Genetic polymorphisms of ADH1C and CYP2E1 and risk of oral squamous cell carcinomaMiroslav Broćić
Clinic for Maxillofacial Surgery, Military Medical Academy, Belgrade, Serbia
Otolaryngol Head Neck Surg 145:586-93. 2011..of alcohol is modulated by the polymorphisms in genes encoding ethanol-metabolizing enzymes, including alcohol dehydrogenase 1C, ADH1C, and cytochrome P450-dependent monooxygenase, CYP2E1...
- Alcohol consumption, alcohol dehydrogenase and risk of coronary heart disease in the MONICA/KORA-Augsburg cohort 1994/1995-2002Jan Heidrich
Institute of Epidemiology and Social Medicine, University of Munster, Munster, Germany
Eur J Cardiovasc Prev Rehabil 14:769-74. 2007..Recently, genotype of alcohol dehydrogenase 1C (ADH1C) has been reported to modify the impact of alcohol consumption on the risk of coronary heart ..
- Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndromeJanne S Tolstrup
Center for Alcohol Research, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
Scand J Public Health 38:489-94. 2010..We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking...
- Prospective evaluation of the alcohol dehydrogenase gamma1/gamma2 gene polymorphism and risk of strokeRobert Y L Zee
Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
Stroke 35:e39-42. 2004Genetic polymorphism of the alcohol dehydrogenase type 3 gene (ADH1C) has recently been associated with reduced risk of myocardial infarction. However, data on risk of stroke are not available.
- The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco useEdward S Peters
Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
Cancer Epidemiol Biomarkers Prev 14:476-82. 2005..Alcohol is eliminated through oxidation by alcohol dehydrogenase (ADH). The ADH1C gene is polymorphic and the ADH1C*1 allele metabolizes ethanol to acetaldehyde at a higher rate than the variant ..
- Alcohol consumption and type 2 diabetes: influence of genetic variation in alcohol dehydrogenaseJoline W J Beulens
Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Diabetes 56:2388-94. 2007We sought to investigate whether a polymorphism in the alcohol dehydrogenase 1c (ADH1C) gene modifies the association between alcohol consumption and type 2 diabetes.
- Polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic menAkira Yokoyama
National Hospital Organization Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan
Alcohol Clin Exp Res 34:1246-56. 2010....
- Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependenceXingguang Luo
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
Am J Hum Genet 78:973-87. 2006..In the present study, we genotyped 16 markers within the ADH gene cluster (including the ADH1A, ADH1B, ADH1C, ADH5, ADH6, and ADH7 genes), 4 markers within the ALDH2 gene, and 38 unlinked ancestry-informative markers in a ..
- Alcohol dehydrogenase 3 and risk of squamous cell carcinomas of the head and neckDonghong Wang
Department of Epidemilogy, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
Cancer Epidemiol Biomarkers Prev 14:626-32. 2005In order to examine the association between alcohol dehydrogenase 3 (ADH3) genotypes and risk of head and neck squamous cell carcinomas (HNSCC), we conducted a hospital based case-control study including 348 cases and 330 controls...
- Alcohol consumption, alcohol dehydrogenase 3 polymorphism, and colorectal adenomasEdine W Tiemersma
Division of Human Nutrition and Epidemiology, Wageningen University, 6700 EV Wageningen, The Netherlands
Cancer Epidemiol Biomarkers Prev 12:419-25. 2003..neoplasm and is metabolized to the carcinogen acetaldehyde by the genetically polymorphic alcohol dehydrogenase 3 (ADH3) enzyme...
- Genetic polymorphisms of alcohol metabolising enzymes: their role in susceptibility to oesophageal cancerDong ping Li
Department of Molecular and Cell Biology, University of Witwatersrand, Johannesburg, South Africa
Clin Chem Lab Med 46:323-8. 2008..Alcohol metabolising enzymes exhibit polymorphisms that result in variant alleles with either increased or decreased activity...
- Alcohol intake, myocardial infarction, biochemical risk factors, and alcohol dehydrogenase genotypesJanne S Tolstrup
Center for Alcohol Research, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
Circ Cardiovasc Genet 2:507-14. 2009..We tested associations between alcohol intake and risk of myocardial infarction and risk factors and whether these associations are modified by variations in alcohol dehydrogenases...
- CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer riskBeatrice Mohelnikova-Duchonova
Toxicogenomics Unit, National Institute of Public Health, Prague, Czech Republic
Pancreas 39:144-8. 2010..exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
- Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkersNils Homann
Department of Medicine I, University of Lubeck, Germany
Int J Cancer 118:1998-2002. 2006..The allele ADH1C*1 of ADH1C encodes for an enzyme with a high capacity to generate acetaldehyde...
- Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal statusLisa M Hines
Department of Pharmacology, University of Colorado Health Sciences Center, 12800 East 19th Avenue, Aurora, CO 80010, USA
Atherosclerosis 182:293-300. 2005We previously demonstrated that a functional polymorphism in alcohol dehydrogenase type 1C (ADH1C, also known as ADH3) modifies the association between moderate alcohol consumption and high-density lipoprotein (HDL) levels and risk of ..
- ADH genotype does not modify the effects of alcohol on high-density lipoproteinJohn B Whitfield
Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
Alcohol Clin Exp Res 27:509-14. 2003..It has been proposed that ADH3 genotype modifies the relationships between alcohol intake and cardiovascular disease by altering the HDL response ..
- Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarctionL M Hines
Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
N Engl J Med 344:549-55. 2001A polymorphism in the gene for alcohol dehydrogenase type 3 (ADH3) alters the rate of alcohol metabolism...
- Laryngeal cancer risk in Caucasians is associated with alcohol and tobacco consumption but not modified by genetic polymorphisms in class I alcohol dehydrogenases ADH1B and ADH1C, and glutathione-S-transferases GSTM1 and GSTT1Angela Risch
Division of Toxicology and Cancer Risk Factors German Cancer Research Center DKFZ, Heidelberg, Germany
Pharmacogenetics 13:225-30. 2003..As part of the Rhein-Neckar Larynx-case-control study, this study investigated the potential risk-modifying effect of genetic polymorphisms in enzymes involved in ethanol and tobacco carcinogen metabolism for laryngeal cancer in Germany...
- Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among ScandinaviansA Linneberg
Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup University Hospital, Glostrup, Denmark
Clin Exp Allergy 40:123-30. 2010..However, the ALDH2 487lys is absent in Caucasians...
- Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE reviewPaul Brennan
International Agency for Research on Cancer, Lyon, France
Am J Epidemiol 159:1-16. 2004Possession of the fast metabolizing alleles for alcohol dehydrogenase (ADH), ADH1B*2 and ADH1C*1, and the null allele for aldehyde dehydrogenase (ALDH), ALDH2*2, results in increased acetylaldehyde levels and is hypothesized to increase ..
- Alcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men: British Women's Heart and Health Study and Caerphilly cohortsShah Ebrahim
Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
Atherosclerosis 196:871-8. 2008The alcohol dehydrogenase 1C gene (ADH1C) gamma2gamma2 variant reportedly interacts with moderate alcohol consumption to increase HDL-cholesterol levels and reduce coronary heart disease (CHD)...
- Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese populationIsao Oze
Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
Cancer Epidemiol Biomarkers Prev 18:3097-102. 2009..In Caucasians, significant associations between polymorphisms in ADH1B (rs1229984) and ADH1C (rs698 and rs1693482), and UAT cancer have been observed, despite strong linkage disequilibrium among them...
- Influence of alcohol dehydrogenase 1C polymorphism on the alcohol-cardiovascular disease association (from the Framingham Offspring Study)Luc Djousse
Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University, Boston, MA, USA
Am J Cardiol 96:227-32. 2005..is associated with a lower risk of cardiovascular disease (CVD), little is known of the effects of alcohol dehydrogenase 1C (ADH1C) polymorphism on the association between alcohol and CVD...
- Genetic variation in alcohol dehydrogenase 1C and the beneficial effect of alcohol intake on coronary heart disease risk in the Second Northwick Park Heart StudyJenan Younis
Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College Medical School, 5 University Street, London WC1E 6JF, UK
Atherosclerosis 180:225-32. 2005b>Alcohol dehydrogenase 1C (ADH1C or ADH3) genotype reportedly modifies the association between alcohol consumption and coronary heart disease (CHD) risk, as well as influencing plasma high-density lipoprotein (HDL) levels [Hines LM, ..
- The role of acetaldehyde in upper digestive tract cancer in alcoholicsHelmut K Seitz
Department of Medicine and Laboratory of Alcohol Research, Liver Disease and Nutrition, Salem Medical Centre, Heidelberg, Germany
Transl Res 149:293-7. 2007..In Caucasians, alcohol dehydrogenase 1*1 (ADH1C*1) allele encodes for an alcohol dehydrogenase (ADH) isoenzyme, which produces 2...
- Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosisY C Chao
Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
Am J Gastroenterol 95:2958-64. 2000..The aim of this study was to investigate the differences among Chinese alcoholic patients with esophageal cancer, acute pancreatitis, and liver cirrhosis by studying the genetic polymorphisms of ADH2, ADH3, ALDH2, and P4502E1.
- Cutaneous metabolism of glycol ethersDavid J Lockley
Skin Toxicology Group, Department of Environmental and Occupational Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
Arch Toxicol 79:160-8. 2005..Although ADH1, ADH2 and ADH3 are expressed at the protein level in rat liver, only ADH1 and ADH2 are selectively inhibited by pyrazole and they ..
- Methanol metabolism and embryotoxicity in rat and mouse conceptuses: comparisons of alcohol dehydrogenase (ADH1), formaldehyde dehydrogenase (ADH3), and catalaseCraig Harris
Toxicology Program, Department of Environmental Health Sciences, School of Public Health, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109 2029, USA
Reprod Toxicol 17:349-57. 2003..HCHO) and formic acid (HCOOH) by the enzymes alcohol dehydrogenase (ADH1), formaldehyde dehydrogenase (ADH3), and catalase may contribute to the observed species sensitivity...
- Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver activator protein, and D-element-bindiC van Ooij
Department of Biochemistry, Colorado State University, Fort Collins 80523
Mol Cell Biol 12:3023-31. 1992The human class I alcohol dehydrogenase (ADH) gene family consists of ADH1, ADH2, and ADH3, which are sequentially activated in early fetal, late fetal, and postnatal liver, respectively...
- Characterization of alcohol dehydrogenase 1 and 3 from Neurospora crassa FGSC2489Yong Cheol Park
Department of Biochemistry and Cell Biology, Rice University, 6100 Main St, Houston, TX 77005, USA
Appl Microbiol Biotechnol 76:349-56. 2007..Some also catalyze the formation of carboxylate esters from alcohols and aldehydes. The ADH1 and ADH3 genes of Neurospora crassa FGSC2489 were cloned and expressed in recombinant Escherichia coli to investigate their ..
- Methylenetetrahydrofolate reductase, alcohol dehydrogenase, diet, and risk of colorectal adenomasEdward Giovannucci
Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston Massachusetts 02115, USA
Cancer Epidemiol Biomarkers Prev 12:970-9. 2003..and MTHFR 1298A-->C (gln-->ala)] (associated with reduced MTHFR activity) and in alcohol dehydrogenase 3 [ADH3 (2-2) associated with decreased alcohol catabolism] in relation to risk of colorectal adenoma in the Health ..
- Reduction of S-nitrosoglutathione by alcohol dehydrogenase 3 is facilitated by substrate alcohols via direct cofactor recycling and leads to GSH-controlled formation of glutathione transferase inhibitorsClaudia A Staab
Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
Biochem J 413:493-504. 2008..The present study explored ADH3 (alcohol dehydrogenase 3) in its dual function as GSNOR (GSNO reductase) and glutathione-dependent formaldehyde ..
- Oikopleura dioica alcohol dehydrogenase class 3 provides new insights into the evolution of retinoic acid synthesis in chordatesCristian Canestro
Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
Zoolog Sci 27:128-33. 2010..Among MDR-Adh enzymes, Adh3 is the only member present in non-vertebrates, and whether Adh3 is actually involved in RA biosynthesis remains ..
- Heterogeneous geographic patterns of nucleotide sequence diversity between two alcohol dehydrogenase genes in wild barley (Hordeum vulgare subspecies spontaneum)J Z Lin
Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA
Proc Natl Acad Sci U S A 98:531-6. 2001..subspecies spontaneum (wild barley) are compared between the putative alcohol dehydrogenase 3 locus (denoted "adh3") and alcohol dehydrogenase 1 (adh1), two related but unlinked loci...
- Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1E Borras
Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Spain
Hepatology 31:984-9. 2000Polymorphism at the ADH2 and ADH3 loci of alcohol dehydrogenase (ADH) has been shown to have an effect on the predisposition to alcoholism in Asian individuals. However, the results are not conclusive for white individuals...
- Differential activity of the promoter for the human alcohol dehydrogenase (retinol dehydrogenase) gene ADH3 in neural tube of transgenic mouse embryosM Zgombic-Knight
Cancer Research Center, La Jolla Cancer Research Foundation, California 92037
J Biol Chem 269:6790-5. 1994..pattern for one member of the human ADH family, we have constructed transgenic mouse lines carrying the human ADH3 promoter fused to the lacZ gene. ADH3-lacZ transgene expression was first noted at embryonic day 9...
- Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3Andrei Molotkov
Gene Regulation Program, Burnham Institute, La Jolla, CA 92037, USA
Eur J Biochem 269:2607-12. 2002..Here, Adh1, Adh3, and Adh4 null mutant mice have been examined following acute and chronic vitamin A excess...
- Alcohol dehydrogenase genes: restriction fragment length polymorphisms for ADH4 (pi-ADH) and ADH5 (chi-ADH) and construction of haplotypes among different ADH classesK Edman
Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Boston, MA 02115
Hum Genet 90:395-401. 1992..Pairwise linkage disequilibrium calculations for these new RFLPs and already known RFLPs at the ADH2 and ADH3 loci establish strong linkage disequilibria between polymorphic MspI and BstXI sites in the ADH5 gene as well as ..
- Specificity of human alcohol dehydrogenase 1C*2 (gamma2gamma2) for steroids and simulation of the uncompetitive inhibition of ethanol metabolismBryce V Plapp
Department of Biochemistry, The University of Iowa, Iowa City, IA 52242 1109, USA
Chem Biol Interact 143:183-93. 2003..None of the reactive steroids has a known function in vivo. The activities with the human ADH1C*2 are <10% of those found with the recombinant horse ADH1S, but higher than the activities with recombinant ..
- Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of actionTamara L Wall
Department of Psychiatry, University of California and the Psychology Service, Veterans Affairs San Diego Healthcare System 92161, USA
Ther Drug Monit 27:700-3. 2005Two alcohol dehydrogenase genes (ADHIB and ADH1C on chromosome 4) and one aldehyde dehydrogenase gene (ALDH2 on chromosome 12) exhibit functional polymorphisms that are associated with lower rates of alcohol dependence...
- Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family membersT O'CONNOR
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, U K
Biochem J 343:487-504. 1999Complementary DNA clones encoding human aflatoxin B(1) aldehyde reductase (AKR7A2), aldehyde reductase (AKR1A1), aldose reductase (AKR1B1), dihydrodiol dehydrogenase 1 (AKR1C1) and chlordecone reductase (AKR1C4) have been expressed in ..
- Alcohol, tobacco and genetic susceptibility in relation to cancers of the upper aerodigestive tract in northern ItalyCristina Canova
Department of Environmental Medicine and Public Health, University of Padua, Italy
Tumori 96:1-10. 2010..The study of single nucleotide polymorphisms in upper aerodigestive tract cancer etiology may help to identify high-risk subgroups and to better understand the pathways leading to the development of these cancers...
- Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinomaAkira Yokoyama
National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa 239 0841, Japan
Carcinogenesis 23:1851-9. 2002The genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2), alcohol dehydrogenase-2 (ADH2), ADH3, and glutathione S-transferase M1 (GSTM1) influence the metabolism of alcohol and other carcinogens...
- The intra- and extracellular proteome of Aspergillus niger growing on defined medium with xylose or maltose as carbon substrateXin Lu
Helmholtz Center for Infection Research, Inhoffenstr, Braunschweig, Germany
Microb Cell Fact 9:23. 2010..13 growing on defined medium with xylose or maltose as carbon substrate was carried out using 2-D gel electrophoresis/Maldi-ToF and nano-HPLC MS/MS...
- Genetic polymorphism of alcohol-metabolizing enzyme and alcohol dependence in Polish menH Cichoz-Lach
Department of Gastroenterology, Medical University of Lublin, Poland
Braz J Med Biol Res 43:257-61. 2010..investigate the differences, if present, in the allele and genotype frequency of alcohol dehydrogenase 1B (ADH1B), ADH1C and the microsomal ethanol-oxidizing system (MEOS/CYP2E1) between alcohol-dependent individuals and controls and ..
- Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectorsL I McLellan
Department of Clinical Biochemistry, University of Edinburgh, Royal Infirmary, U K
Biochem J 300:117-24. 1994..In addition, the effect of these drugs on the hepatic levels of an aldehyde reductase (AFB1-AR) that metabolizes the cytotoxic dialdehydic form of AFB1 has been studied as this enzyme also ..
- Association of the ADH2*3 allele with a negative family history of alcoholism in African American young adultsC L Ehlers
Department of Neuropharmacology, The Scripps Research Institute, LaJolla, California, USA
Alcohol Clin Exp Res 25:1773-7. 2001Two of the class I alcohol dehydrogenase (ADH) genes (ADH2 and ADH3) encode for multiple isozymes that differ in their kinetic properties...
- Molecular and metabolic retinoid pathways in the human ocular surfaceHachemi Nezzar
Universite d Auvergne, JE 2447, ARDEMO, France
Mol Vis 13:1641-50. 2007..The second objective was to demonstrate the presence of different enzymes transforming vitamin A to retinoic acid and the functionality of this metabolic pathway in the corneal epithelium...
- Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family membersTeruhiko Iino
Department of General Studies, Nihon University, Sakurajosui 3 25 40, Setagaya Ku, Tokyo 156 8550, Japan
Arch Biochem Biophys 416:180-7. 2003..by 3 alpha-hydroxysteroid dehydrogenase type 2, whereas 1(')-OXPH(4) was produced by aldose reductase, aldehyde reductase, and 20 alpha-hydroxysteroid dehydrogenase, and both 1(')-OXPH(4) and 2(')-OXPH(4) were detected as the ..
- Vitamin C. Biosynthesis, recycling and degradation in mammalsCarole L Linster
Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Brussels, Belgium
FEBS J 274:1-22. 2007..Glucuronate is converted to l-gulonate by aldehyde reductase, an enzyme of the aldo-keto reductase superfamily...
- Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1J D Hayes
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
Chem Biol Interact 111:51-67. 1998..In addition to GSTA5, we have identified a novel aflatoxin-aldehyde reductase (AFAR) that is similarly induced by ethoxyquin...
- Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxinJ D Hayes
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom
Cancer Res 53:3887-94. 1993..Therefore, this inducible enzyme has been designated aflatoxin B1-aldehyde reductase (AFB1-AR)...
- Molecular epidemiological studies in 1,3-butadiene exposed Czech workers: female-male comparisonsRichard J Albertini
BioMosaics, Inc, 665 Spear Street, Burlington, VT 05401, USA
Chem Biol Interact 166:63-77. 2007..GSTT1, CYP2E1 (5' promoter), CYP2E1 (intron 6), EH [epoxide hydrolase] 113, EH139, ADH [alcohol dehydrogenase]2 and ADH3). The no observed adverse effect level (NOAEL) for chromosome aberrations and HPRT mutations was 1.794 mg/m(3) (0...
- The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cellsJan Vondracek
Department of Cytokinetics, Institute of Biophysics ASCR, Brno, Czech Republic
Chem Biol Interact 180:226-37. 2009..In contrast, the aldehyde reductase AKR1A1 was not induced by either treatment...
- Aldose reductase: an aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic gangliaMinoru Kawamura
Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
Auton Neurosci 96:131-9. 2002..Although similar formation of DHPG was observed with human liver aldehyde reductase, the production of DHPG was more effective with aldose reductase than aldehyde reductase...
- Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometryDenise N Johnson
Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
Chem Res Toxicol 21:752-60. 2008..This urinary detection of the alcohol products directly contributes to the goal of mass balancing the fate of the bioreactive 8,9-epoxides of AFB 1 in vivo...
- Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoterElizabeth M Ellis
Department of Bioscience and Pharmaceutical Sciences, University of Strathclyde, Glasgow G1 1XW, UK
Carcinogenesis 24:727-37. 2003Rat aflatoxin B(1) aldehyde reductase (called AFAR1 or AKR7A1) is a member of the aldo-keto reductase 7 family, which metabolizes the environmental carcinogen aflatoxin B(1)...
- Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteinsVincent P Kelly
Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
Biochem J 366:847-61. 2002The aldo-keto reductase (AKR) 7 family is composed of the dimeric aflatoxin B(1) aldehyde reductase (AFAR) isoenzymes. In the rat, two AFAR subunits exist, designated rAFAR1 and rAFAR2...
- Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductaseC J Winters
Department of Medicine, Medical College of Virginia, Richmond 23298
Biochemistry 29:1080-7. 1990..The deduced protein sequence of CDR showed 65% similarity to the primary structure of human liver aldehyde reductase and 66% similarity to the inferred protein sequence of rat lens aldose reductase...
- Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cellsC Praml
Division of Cytogenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Cancer Res 58:5014-8. 1998..a gene encoding a protein of 330 amino acids that is 78% identical with the Rattus norvegicus aflatoxin B1 aldehyde reductase (Afar) and, therefore, likely represents its human homologue...
- Enzymes in pancreatic islets that use NADP(H) as a cofactor including evidence for a plasma membrane aldehyde reductaseM Laclau
University of Wisconsin Childrens Diabetes Center, Madison, USA
Mol Cell Biochem 225:151-60. 2001..Significant activities of glutathione reductase, aldose reductase (EC.22.214.171.124) and aldehyde reductase (EC.126.96.36.199) were present in islets...
- Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activitiesKevork Hagopian
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Biosci Rep 28:107-15. 2008..Aldehyde dehydrogenase and aldehyde reductase activities in both young and old CR mice were unchanged by caloric restriction...
- Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activityW R Lacy
Department of Cell Biology, Baylor College of Medicine Houston, Texas 77030
Mol Endocrinol 7:58-66. 1993..to human chlordecone reductase, bovine lung prostaglandin F synthase, human aldose reductase, human aldehyde reductase, and frog lens rho-crystallin, placing rabbit ovarian 20 alpha HSD in the aldo-keto reductase family of ..
- Purification and characterization of human testis aldose and aldehyde reductaseT Tanimoto
Division of Biological Chemistry, National Institute of Hygienic Sciences, Tokyo, Japan
Int J Biochem 23:421-8. 19911. Aldose reductase and aldehyde reductase were purified to homogeneity from human testis. 2...
- Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3Sridevi Bodreddigari
Department of Biology and W Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, Tennessee 38152, USA
Chem Res Toxicol 21:1134-42. 2008..B 1 (AFB 1) dialdehyde metabolite to its corresponding mono and dialcohols, catalyzed by aflatoxin B 1-aldehyde reductase (AFAR, rat AKR7A1, and human AKR7A3), is greatly increased in livers of rats treated with numerous ..
- A new view of alcohol metabolism and alcoholism--role of the high-Km Class III alcohol dehydrogenase (ADH3)Takeshi Haseba
Department of Legal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
Int J Environ Res Public Health 7:1076-92. 2010..Recently, using ADH3-null mutant mice, we demonstrated that ADH3 (Class III), which has a high K(m) and is a ubiquitous enzyme of ..
- Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the ratBill D Roebuck
Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
Toxicol Sci 109:41-9. 2009..These results imply that the prevention of protein adducts mediated by AKR are not critical to protection against AFB(1) tumorigenicity...
- [A new sight on alcohol metabolism and alcoholism--role of high Km alcohol dehydrogenase ADH3 (Class III)]Takeshi Haseba
Department of Legal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
Nihon Arukoru Yakubutsu Igakkai Zasshi 44:78-93. 2009..Recently, we used ADH3-null mutant mice to demonstrate that high Km ADH3 (Class III), a ubiquitous enzyme of ancient origin, contributes ..
- Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase); immunohistochemical detection in breast and prostateHsueh Kung Lin
Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19018, USA
Steroids 69:795-801. 2004..It does not cross react with human AKR1C1, AKR1C2 or AKR1C4, human aldehyde reductase AKR1A1 or rat 3alpha-hydroxysteroid dehydrogenase (AKR1C9) on immunoblot analysis...
- Purification and characterization of a novel cytosolic NADP(H)-dependent retinol oxidoreductase from rabbit liverD Y Huang
Department of Biochemistry, School of Medicine, Kagawa Medical University, Japan
Biochim Biophys Acta 1338:47-59. 1997..This enzyme exhibits relatively broad aldehyde reductase activity and some ketone reductase activity, the activity for aromatic substitutive aldehydes being ..
- A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidantD J Judah
MRC Toxicology Unit, Carshalton, Surrey, U K
Biochem J 292:13-8. 1993In contrast with fractions from control animals, an aldehyde reductase, which catalyses the reduction of aflatoxin B1-dihydrodiol, in the dialdehyde form at physiological pH values, to aflatoxin B1-dialcohol, is expressed in cytosolic ..
- Cloning and expression of two novel aldo-keto reductases from Digitalis purpurea leavesIsabel Gavidia
Center of Plant Molecular Biology ZMBP, University of Tubingen, Germany
Eur J Biochem 269:2842-50. 2002..proteins present high identities (68-80%) with four Arabidopsis clones and a 67% identity with the aldose/aldehyde reductase from Medicago sativa...
- Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frogK Watanabe
Hayaishi Bioinformation Transfer Project, Kyoto Laboratory, Research Development Corporation of Japan
Proc Natl Acad Sci U S A 85:11-5. 1988..that bovine lung PGF synthase shows 62% identical plus conservative substitutions compared with human liver aldehyde reductase [Wermuth, B., Omar, A., Forster, A., Francesco, C., Wolf, M., Wartburg, J.P., Bullock, B. & Gabbay, K.H...
- Molecular Mechanisms of Multistage CarcinogenesisTREVOR PENNING; Fiscal Year: 2006..Project # 1 (Dr. Penning) will compare the roles of human aldehyde reductase (AKR1A1), CYP1A1/CYP1B1, and CYP-peroxidase in the metabolic activation of PAH using a stable expression ..
- RESPONSE TO ALCOHOL IN ASIAN MEN AND WOMENTAMARA WALL; Fiscal Year: 2000..test response to both placebo and alcohol administration among men and women of Asian heritage with different ADH2, ADH3, and ALDH2 genotypes. This study will focus on various measures of reaction to alcohol and alcohol metabolism...
- ALCOHOL PHARMACOGENETICS IN MEXICAN AMERICANSYU JUI WAN; Fiscal Year: 2009..for both ALDH2*2 (aldehyde dehydrogenase) and ADH2*2 (alcohol dehydrogenase);(2) a relatively high rate of ADH3*2 and CYP2E1 c2 (cytochrome P4502E1) alleles;(3) association of ADH3*2, ADH2*1, DRD2 (dopamine receptor -141C Del/..
- GENETICS OF ALCOHOL SENSITIVITYShozo Yokoyama; Fiscal Year: 1992..of alcohol sensitivity, we propose to characterize all ADH genes, including not only those at the ADH1, ADH2, and ADH3 loci of class I but also those of the class II and III loci...
- ALCOHOL METABOLISM GENES IN TRANSGENIC MICEMichael Felder; Fiscal Year: 2007..in the liver of mammals A single gene, Adh1, encodes class I ADH in mice while three genes, ADH1A, ADH1B and ADH1C, encode class I polypeptides in humans The overall goals are to identify distal genomic dements that control the ..
- STRUCTURE & EXPRESSION OF MAMMAL ALC DEHYDROGENASE GENESHoward Edenberg; Fiscal Year: 2000..are important in the regulation of tissue-specific expression of the human and mouse class I ADH genes ADH1, ADH2, ADH3 and Adh1...
- Genetic Factors and Cardiovascular DiseaseLuc Djousse; Fiscal Year: 2006..We will use data collected on Framingham Offspring participants to test 1) whether variants of ADH3 genotypes modify the association between alcohol intake and CHD, HDL-cholesterol, frequency, amount, and type of ..
- Protein Modification by 3,4-DihydroxyphenylacetaldehydeJONATHAN DOORN; Fiscal Year: 2006..metabolized primarily to an acid via mitochondrial aldehyde dehydrogenase (ALDH2) but also to an alcohol by aldehyde reductase (ALR). Recent work implicates oxidative stress and lipid peroxidation products, e.g...
- ALDO-KETO REDUCTASES AS PART OF CHEMICAL STRESS RESPONSEOleg Barski; Fiscal Year: 2002..Recently it was shown that ethoxyquin and antiobiotic tunicamycin also induce aldehyde reductase, another member of the aldo-keto reductase family...
- STRUCTURAL IDENTIFICATION OF PROSTAGLANDIN CONJUGATESL Roberts; Fiscal Year: 2000..The ability of PGF-synthase and liver aldehyde reductase to reduce IsoP endoperoxides to F-ring IsoP's will also be examined...
- Folate, Vitamin D and Calcium in Colorectal CancerRobert Haile; Fiscal Year: 2009..factor (GIF), transcobalamin II (TCII), intrinsic factor cobalamin receptor (IFCR), and alcohol dehydrogenase 3 (ADH3). Vitamin D and Calcium...