ADH1C

Summary

Gene Symbol: ADH1C
Description: alcohol dehydrogenase 1C (class I), gamma polypeptide
Alias: ADH3, ADH, gamma subunit, alcohol dehydrogenase 1C, alcohol dehydrogenase 3 (class I), gamma polypeptide, alcohol dehydrogenase subunit gamma, aldehyde reductase
Species: human

Top Publications

  1. ncbi A mapping study of 13 genes on human chromosome bands 4q11-->q25
    C S Chen
    Department of Laboratory Medicine Pathology, University of Minnesota, Minneapolis 55455, USA
    Cytogenet Cell Genet 69:260-5. 1995
  2. ncbi Aldose reductase in human retinal pigment epithelial cells
    S Sato
    Laboratory of Ocular Therapeutics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
    Exp Eye Res 57:235-41. 1993
  3. ncbi Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin
    R McLeod
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom
    Cancer Res 57:4257-66. 1997
  4. ncbi Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes
    Janne Schurmann Tolstrup
    Center for Alcohol Research, National Institute of Public Health, Copenhagen, Denmark
    Pharmacogenomics J 8:220-7. 2008
  5. pmc Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample
    Po Hsiu Kuo
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
    Alcohol Clin Exp Res 32:785-95. 2008
  6. pmc Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
  7. ncbi Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe
    P Soucek
    National Institute of Public Health, Prague, Czech Republic
    Neoplasma 57:415-21. 2010
  8. pmc Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
    Carcinogenesis 28:1672-9. 2007
  9. pmc Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster
    Josef Frank
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Germany
    Addict Biol 17:171-80. 2012
  10. doi Polymorphisms in alcohol metabolizing genes and the risk of head and neck cancer in a Brazilian population
    Silvia Marçal Nunes Garcia
    Department of Legal Medicine, Bioethics and Occupational Health, School of Medicine, Sao Paulo, SP, Brazil
    Alcohol Alcohol 45:6-12. 2010

Research Grants

Detail Information

Publications192 found, 100 shown here

  1. ncbi A mapping study of 13 genes on human chromosome bands 4q11-->q25
    C S Chen
    Department of Laboratory Medicine Pathology, University of Minnesota, Minneapolis 55455, USA
    Cytogenet Cell Genet 69:260-5. 1995
    ..The alcohol dehydrogenase, class I (ADH2, ADH3) gene cluster can be linked to the alcohol dehydrogenase, class III gene (ADH5) by SacII, NruI, and EagI digests...
  2. ncbi Aldose reductase in human retinal pigment epithelial cells
    S Sato
    Laboratory of Ocular Therapeutics, National Eye Institute, National Institutes of Health, Bethesda, MD 20892
    Exp Eye Res 57:235-41. 1993
    ..In addition to aldose reductase, chromatofocusing demonstrated the presence of aldehyde reductase, another NADPH-dependent reductase...
  3. ncbi Protection conferred by selenium deficiency against aflatoxin B1 in the rat is associated with the hepatic expression of an aldo-keto reductase and a glutathione S-transferase subunit that metabolize the mycotoxin
    R McLeod
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom
    Cancer Res 57:4257-66. 1997
    ..The elevation in hepatic AFB1-aldehyde reductase (AFAR) activity in selenium-deficient animals is accompanied by an increase of 11- and 15-fold in the levels ..
  4. ncbi Alcoholism and alcohol drinking habits predicted from alcohol dehydrogenase genes
    Janne Schurmann Tolstrup
    Center for Alcohol Research, National Institute of Public Health, Copenhagen, Denmark
    Pharmacogenomics J 8:220-7. 2008
    ..dehydrogenase (ADH) wherein genetic variation that affects the rate of alcohol degradation is found in ADH1B and ADH1C. It is biologically plausible that these variations may be associated with alcohol drinking habits and alcoholism...
  5. pmc Association of ADH and ALDH genes with alcohol dependence in the Irish Affected Sib Pair Study of alcohol dependence (IASPSAD) sample
    Po Hsiu Kuo
    Institute of Clinical Medicine, College of Medicine, National Cheng Kung University Hospital 138, National Cheng Kung University, Sheng Li Road, Tainan 704, Taiwan
    Alcohol Clin Exp Res 32:785-95. 2008
    ..The present study examined evidence for the association of alcohol metabolism genes with AD in the Irish Affected Sib Pair Study of alcohol dependence...
  6. pmc Associations of ADH and ALDH2 gene variation with self report alcohol reactions, consumption and dependence: an integrated analysis
    Stuart Macgregor
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Hum Mol Genet 18:580-93. 2009
    ..7 x 10(-5)) and suggestive associations (P<0.001) between alcohol consumption phenotypes and rs1693482 (ADH1C), rs1230165 (ADH5) and rs3762894 (ADH4)...
  7. ncbi Polymorphisms in metabolizing enzymes and the risk of head and neck squamous cell carcinoma in the Slavic population of the central Europe
    P Soucek
    National Institute of Public Health, Prague, Czech Republic
    Neoplasma 57:415-21. 2010
    ..metabolizing smoke constituents and/or alcohol (CYP2A13, CYP1B1, EPHX1, NQO1, GSTM1, GSTP1, GSTT1, ADH1B and ADH1C)...
  8. pmc Genetic polymorphisms in one-carbon metabolism: associations with CpG island methylator phenotype (CIMP) in colon cancer and the modifying effects of diet
    Karen Curtin
    Department of Internal Medicine, University of Utah Health Sciences Center, 375 Chipeta Way, Suite A, Salt Lake City, UT 84108, USA
    Carcinogenesis 28:1672-9. 2007
    ..methylenetetrahydrofolate dehydrogenase 1 (MTHFD1), dihydrofolate reductase (DHFR) and alcohol dehydrogenase 3 (ADH3) were evaluated. CIMP- or CIMP+ phenotype was based on five CpG island markers: MINT1, MINT2, MINT31, p16 and MLH1...
  9. pmc Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster
    Josef Frank
    Department of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, University of Heidelberg, Germany
    Addict Biol 17:171-80. 2012
    ..The single nucleotide polymorphism (SNP) rs1789891, which is located between the ADH1B and ADH1C genes, achieved genome-wide significance [P = 1.27E-8, odds ratio (OR) = 1.46]...
  10. doi Polymorphisms in alcohol metabolizing genes and the risk of head and neck cancer in a Brazilian population
    Silvia Marçal Nunes Garcia
    Department of Legal Medicine, Bioethics and Occupational Health, School of Medicine, Sao Paulo, SP, Brazil
    Alcohol Alcohol 45:6-12. 2010
    ..The aim of this study was to evaluate the association of polymorphisms in genes of alcohol metabolism enzymes and the risk of HNC...
  11. ncbi Alcohol dehydrogenase 3 genotype as a risk factor for upper aerodigestive tract cancers
    Ines Nobuko Nishimoto
    Department of Head and Neck Surgery and Otorhinolaryngology, Centro de Tratamento e Pesquisa Hospital do Cancer A C Camargo, Sao Paulo, Brazil
    Arch Otolaryngol Head Neck Surg 130:78-82. 2004
    To assess alcohol dehydrogenase 3 (ADH3) polymorphism at position Ile349Val as indicator of risk factor for upper aerodigestive tract (UADT) cancer to verify its association with UADT cancer in nonalcoholic or nonsmoking individuals.
  12. ncbi Genetic polymorphisms in alcohol metabolism, alcohol intake and the risk of stomach cancer in Warsaw, Poland
    Fang Fang Zhang
    Department of Epidemiology, School of Public Health, University of North Texas Health Science Center, Fort Worth, TX 76107, USA
    Int J Cancer 121:2060-4. 2007
    ..in alcohol metabolizing genes, including ADH1B (Ex9+5C>T, Ex3+23A>G, Ex3+58A>T and Ex9+77A>G), ADH1C (Ex8-56A>G and Ex6-14G>A) and ALDH2 (Ex1+82A>G), on levels of alcohol drinking and susceptibility of ..
  13. ncbi Genetic polymorphisms of alcohol and aldehyde dehydrogenases, and drinking, smoking and diet in Japanese men with oral and pharyngeal squamous cell carcinoma
    Takahiro Asakage
    Department of Otorlaryngology, University of Tokyo, Bunkyo ku, Tokyo 113 8655, Japan
    Carcinogenesis 28:865-74. 2007
    ..polymorphisms of aldehyde dehydrogenase-2 (ALDH2), alcohol dehydrogenase-1B (ADH1B, previously called ADH2), and ADH1C (previously called ADH3) affect the metabolism of alcohol...
  14. ncbi Role of epoxide hydrolase, NAD(P)H:quinone oxidoreductase, cytochrome P450 2E1 or alcohol dehydrogenase genotypes in susceptibility to colorectal cancer
    Elise M J van der Logt
    Department of Gastroenterology, University Medical Centre, St Radboud, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Mutat Res 593:39-49. 2006
    ..hydrolase (EPHX1), NAD(P)H:quinone oxidoreductase (NQO1), cytochrome P450 2E1 (CYP2E1) and alcohol dehydrogenase (ADH3) predispose to the development of CRC...
  15. ncbi Risk of head and neck cancer and the alcohol dehydrogenase 3 genotype
    A F Olshan
    Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC 27599 7400, USA
    Carcinogenesis 22:57-61. 2001
    ..The joint effects of lifetime alcohol use and the presence of the ADH3 'rapid' allele (ADH3(*)1) was evaluated in relation to the risk of SCCHN...
  16. ncbi Alcohol dehydrogenase 3 genotype is not associated with risk of squamous cell carcinoma of the oral cavity and pharynx
    E M Sturgis
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston 77030, USA
    Cancer Epidemiol Biomarkers Prev 10:273-5. 2001
    ..To test this hypothesis, we investigated the association between the ADH3 genotype and oral and pharyngeal cancer risk in a large racially homogeneous case-control study of 229 patients and ..
  17. ncbi Interaction between a single nucleotide polymorphism in the alcohol dehydrogenase 3 gene, alcohol consumption and oral cancer risk
    Athanasios I Zavras
    Department of Oral Health Policy and Epidemiology, Harvard School of Dental Medicine, Boston, MA, USA
    Int J Cancer 97:526-30. 2002
    ..cancer (OC) risk of an interaction between a single nucleotide polymorphism (SNP) in the alcohol dehydrogenase 3 (ADH3) gene and alcohol consumption levels using a hospital-based study of 93 cases and 99 controls conducted in Athens, ..
  18. pmc Alcohol dehydrogenase genetic polymorphisms, low-to-moderate alcohol consumption, and risk of breast cancer
    Kala Visvanathan
    Department of Epidemiology, The Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Alcohol Clin Exp Res 31:467-76. 2007
    In vitro, human isoenzymes encoded by genes homozygous for the ADH1C*1 or ADH1B*2 alleles metabolize ethanol to acetaldehyde at a faster rate than those homozygous for the ADH1C*2 or ADH1B*1 allele...
  19. ncbi Oral squamous cell cancer risk in relation to alcohol consumption and alcohol dehydrogenase-3 genotypes
    S M Schwartz
    Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, 98109 1024, USA
    Cancer Epidemiol Biomarkers Prev 10:1137-44. 2001
    ..Alcohol dehydrogenase 3 (ADH3) converts ethanol to acetaldehyde, which is a suspected oral carcinogen...
  20. doi Variability in ethanol biodisposition in whites is modulated by polymorphisms in the ADH1B and ADH1C genes
    Carmen Martinez
    Department of Pharmacology, Medical School, University of Extremadura, Badajoz, Spain
    Hepatology 51:491-500. 2010
    ..and acoustic signals, and we analyzed 13 single nucleotide polymorphism (SNPs) in the genes coding for ADH1B, ADH1C, ALDH2, and CYP2E1 in 250 healthy white individuals...
  21. ncbi ADH3 genotype, alcohol intake and breast cancer risk
    Mary Beth Terry
    Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA, and Prosserman Centre for Health Research, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Carcinogenesis 27:840-7. 2006
    ..Individuals differ in their ADH genotype, and one locus in particular (ADH3) is polymorphic in Caucasian populations...
  22. doi Frequencies of ADH1C alleles and genotypes in a Turkish head and neck cancer population
    S Kortunay
    Department of Pharmacology, Faculty of Medicine, Pamukkale University, Denizli, Turkey
    Methods Find Exp Clin Pharmacol 32:187-91. 2010
    ..The genomic DNA was isolated from peripheral blood leukocytes. The ADH1C*1 wild-type and ADH1C*2 variant alleles were analyzed with an RFLP method by using SspI as restriction enzyme...
  23. ncbi Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas
    Mary Beth Terry
    Mailman School of Public Health, Department of Epidemiology, Columbia University, 722 West 168th Street, Room 724A, New York, NY 10032, USA
    Cancer Causes Control 18:1039-46. 2007
    ..The alcohol dehydrogenase gene has several polymorphisms which may lead to faster conversion of ethanol to acetaldehyde, which may increase cancer risk...
  24. ncbi Risk factors in alcohol associated breast cancer: alcohol dehydrogenase polymorphism and estrogens
    C Coutelle
    Department of Medicine and Laboratory of Alcohol Research, Liver Disease and Nutrition, Salem Medical Centre, Heidelberg, Germany
    Int J Oncol 25:1127-32. 2004
    ..acetaldehyde is a carcinogenic factor associated with chronic alcohol consumption, individuals with the alcohol dehydrogenase 1C*1 allele (ADH1C*1 allele) seem to be at particular risk, since this allele encodes for a rapidly ethanol ..
  25. ncbi Alcohol dehydrogenase and aldehyde dehydrogenase polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study
    Guang Yin
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 98:1248-53. 2007
    ..The present case-control study was conducted to determine the influence of ADH2, ADH3 and ALDH2 polymorphisms in Fukuoka, Japan, with 685 incident cases of histologically confirmed colorectal ..
  26. ncbi Lung cancer in humans is not associated with lifetime total alcohol consumption or with genetic variation in alcohol dehydrogenase 3 (ADH3)
    Jo L Freudenheim
    Department of Social and Preventive Medicine, School of Public Health and Health Professions, University at Buffalo, State University of New York, Buffalo, NY 14260, USA
    J Nutr 133:3619-24. 2003
    ..In addition we examined the alcohol dehydrogenase 3 (ADH3) genotype in relation to lung cancer risk; ADH3 is rate limiting in alcohol metabolism and has a functional ..
  27. doi Polymorphism in ADH and MTHFR genes in oral squamous cell carcinoma of Indians
    P R Solomon
    Department of Biochemistry, Centre for Advanced Studies in Functional Genomics, School of Biological Sciences, Madurai Kamaraj University, Madurai, India
    Oral Dis 14:633-9. 2008
    ..Therefore, this study is designed to asses the polymorphic status in ADH1B (formerly ADH2), ADH1C (formerly ADH3) and MTHFR genes in order to correlate the susceptibility to oral squamous cell carcinoma (OSCC).
  28. ncbi Alcohol dehydrogenase type 3 (ADH3) and the risk of bladder cancer
    B Van Dijk
    Department of Urology, University Medical Centre, Nijmegen, The Netherlands
    Eur Urol 40:509-14. 2001
    ..Objectives of this pilot study are to determine whether this polymorphism may be related to bladder cancer and whether it modifies the relation between alcohol intake and bladder cancer...
  29. doi Genetic polymorphisms of ADH1C and CYP2E1 and risk of oral squamous cell carcinoma
    Miroslav Broćić
    Clinic for Maxillofacial Surgery, Military Medical Academy, Belgrade, Serbia
    Otolaryngol Head Neck Surg 145:586-93. 2011
    ..of alcohol is modulated by the polymorphisms in genes encoding ethanol-metabolizing enzymes, including alcohol dehydrogenase 1C, ADH1C, and cytochrome P450-dependent monooxygenase, CYP2E1...
  30. ncbi Alcohol consumption, alcohol dehydrogenase and risk of coronary heart disease in the MONICA/KORA-Augsburg cohort 1994/1995-2002
    Jan Heidrich
    Institute of Epidemiology and Social Medicine, University of Munster, Munster, Germany
    Eur J Cardiovasc Prev Rehabil 14:769-74. 2007
    ..Recently, genotype of alcohol dehydrogenase 1C (ADH1C) has been reported to modify the impact of alcohol consumption on the risk of coronary heart ..
  31. doi Alcohol drinking habits, alcohol dehydrogenase genotypes and risk of acute coronary syndrome
    Janne S Tolstrup
    Center for Alcohol Research, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
    Scand J Public Health 38:489-94. 2010
    ..We aimed to test this hypothesis, including alcohol as both the amount of alcohol and the frequency of drinking...
  32. ncbi Prospective evaluation of the alcohol dehydrogenase gamma1/gamma2 gene polymorphism and risk of stroke
    Robert Y L Zee
    Center for Cardiovascular Disease Prevention and the Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    Stroke 35:e39-42. 2004
    Genetic polymorphism of the alcohol dehydrogenase type 3 gene (ADH1C) has recently been associated with reduced risk of myocardial infarction. However, data on risk of stroke are not available.
  33. ncbi The ADH1C polymorphism modifies the risk of squamous cell carcinoma of the head and neck associated with alcohol and tobacco use
    Edward S Peters
    Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Cancer Epidemiol Biomarkers Prev 14:476-82. 2005
    ..Alcohol is eliminated through oxidation by alcohol dehydrogenase (ADH). The ADH1C gene is polymorphic and the ADH1C*1 allele metabolizes ethanol to acetaldehyde at a higher rate than the variant ..
  34. ncbi Alcohol consumption and type 2 diabetes: influence of genetic variation in alcohol dehydrogenase
    Joline W J Beulens
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetes 56:2388-94. 2007
    We sought to investigate whether a polymorphism in the alcohol dehydrogenase 1c (ADH1C) gene modifies the association between alcohol consumption and type 2 diabetes.
  35. doi Polymorphisms of alcohol dehydrogenase-1B and aldehyde dehydrogenase-2 and the blood and salivary ethanol and acetaldehyde concentrations of Japanese alcoholic men
    Akira Yokoyama
    National Hospital Organization Kurihama Alcoholism Center, Yokosuka, Kanagawa, Japan
    Alcohol Clin Exp Res 34:1246-56. 2010
    ....
  36. pmc Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence
    Xingguang Luo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Hum Genet 78:973-87. 2006
    ..In the present study, we genotyped 16 markers within the ADH gene cluster (including the ADH1A, ADH1B, ADH1C, ADH5, ADH6, and ADH7 genes), 4 markers within the ALDH2 gene, and 38 unlinked ancestry-informative markers in a ..
  37. ncbi Alcohol dehydrogenase 3 and risk of squamous cell carcinomas of the head and neck
    Donghong Wang
    Department of Epidemilogy, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA
    Cancer Epidemiol Biomarkers Prev 14:626-32. 2005
    In order to examine the association between alcohol dehydrogenase 3 (ADH3) genotypes and risk of head and neck squamous cell carcinomas (HNSCC), we conducted a hospital based case-control study including 348 cases and 330 controls...
  38. ncbi Alcohol consumption, alcohol dehydrogenase 3 polymorphism, and colorectal adenomas
    Edine W Tiemersma
    Division of Human Nutrition and Epidemiology, Wageningen University, 6700 EV Wageningen, The Netherlands
    Cancer Epidemiol Biomarkers Prev 12:419-25. 2003
    ..neoplasm and is metabolized to the carcinogen acetaldehyde by the genetically polymorphic alcohol dehydrogenase 3 (ADH3) enzyme...
  39. doi Genetic polymorphisms of alcohol metabolising enzymes: their role in susceptibility to oesophageal cancer
    Dong ping Li
    Department of Molecular and Cell Biology, University of Witwatersrand, Johannesburg, South Africa
    Clin Chem Lab Med 46:323-8. 2008
    ..Alcohol metabolising enzymes exhibit polymorphisms that result in variant alleles with either increased or decreased activity...
  40. doi Alcohol intake, myocardial infarction, biochemical risk factors, and alcohol dehydrogenase genotypes
    Janne S Tolstrup
    Center for Alcohol Research, National Institute of Public Health, University of Southern Denmark, Copenhagen, Denmark
    Circ Cardiovasc Genet 2:507-14. 2009
    ..We tested associations between alcohol intake and risk of myocardial infarction and risk factors and whether these associations are modified by variations in alcohol dehydrogenases...
  41. doi CYP2A13, ADH1B, and ADH1C gene polymorphisms and pancreatic cancer risk
    Beatrice Mohelnikova-Duchonova
    Toxicogenomics Unit, National Institute of Public Health, Prague, Czech Republic
    Pancreas 39:144-8. 2010
    ..exposure-related cancers, we studied the association of polymorphisms in the tobacco carcinogen-metabolizing gene CYP2A13 (Arg101Stop) and the alcohol-metabolizing genes ADH1B (Arg48His) and ADH1C (Ile350Val) with pancreatic cancer risk.
  42. ncbi Alcohol dehydrogenase 1C*1 allele is a genetic marker for alcohol-associated cancer in heavy drinkers
    Nils Homann
    Department of Medicine I, University of Lubeck, Germany
    Int J Cancer 118:1998-2002. 2006
    ..The allele ADH1C*1 of ADH1C encodes for an enzyme with a high capacity to generate acetaldehyde...
  43. ncbi Alcohol consumption and high-density lipoprotein levels: the effect of ADH1C genotype, gender and menopausal status
    Lisa M Hines
    Department of Pharmacology, University of Colorado Health Sciences Center, 12800 East 19th Avenue, Aurora, CO 80010, USA
    Atherosclerosis 182:293-300. 2005
    We previously demonstrated that a functional polymorphism in alcohol dehydrogenase type 1C (ADH1C, also known as ADH3) modifies the association between moderate alcohol consumption and high-density lipoprotein (HDL) levels and risk of ..
  44. ncbi ADH genotype does not modify the effects of alcohol on high-density lipoprotein
    John B Whitfield
    Department of Clinical Biochemistry, Royal Prince Alfred Hospital, Camperdown NSW 2050, Australia
    Alcohol Clin Exp Res 27:509-14. 2003
    ..It has been proposed that ADH3 genotype modifies the relationships between alcohol intake and cardiovascular disease by altering the HDL response ..
  45. ncbi Genetic variation in alcohol dehydrogenase and the beneficial effect of moderate alcohol consumption on myocardial infarction
    L M Hines
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    N Engl J Med 344:549-55. 2001
    A polymorphism in the gene for alcohol dehydrogenase type 3 (ADH3) alters the rate of alcohol metabolism...
  46. ncbi Laryngeal cancer risk in Caucasians is associated with alcohol and tobacco consumption but not modified by genetic polymorphisms in class I alcohol dehydrogenases ADH1B and ADH1C, and glutathione-S-transferases GSTM1 and GSTT1
    Angela Risch
    Division of Toxicology and Cancer Risk Factors German Cancer Research Center DKFZ, Heidelberg, Germany
    Pharmacogenetics 13:225-30. 2003
    ..As part of the Rhein-Neckar Larynx-case-control study, this study investigated the potential risk-modifying effect of genetic polymorphisms in enzymes involved in ethanol and tobacco carcinogen metabolism for laryngeal cancer in Germany...
  47. doi Genetic determinants of both ethanol and acetaldehyde metabolism influence alcohol hypersensitivity and drinking behaviour among Scandinavians
    A Linneberg
    Research Centre for Prevention and Health, The Capital Region of Denmark, Glostrup University Hospital, Glostrup, Denmark
    Clin Exp Allergy 40:123-30. 2010
    ..However, the ALDH2 487lys is absent in Caucasians...
  48. ncbi Pooled analysis of alcohol dehydrogenase genotypes and head and neck cancer: a HuGE review
    Paul Brennan
    International Agency for Research on Cancer, Lyon, France
    Am J Epidemiol 159:1-16. 2004
    Possession of the fast metabolizing alleles for alcohol dehydrogenase (ADH), ADH1B*2 and ADH1C*1, and the null allele for aldehyde dehydrogenase (ALDH), ALDH2*2, results in increased acetylaldehyde levels and is hypothesized to increase ..
  49. ncbi Alcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men: British Women's Heart and Health Study and Caerphilly cohorts
    Shah Ebrahim
    Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, UK
    Atherosclerosis 196:871-8. 2008
    The alcohol dehydrogenase 1C gene (ADH1C) gamma2gamma2 variant reportedly interacts with moderate alcohol consumption to increase HDL-cholesterol levels and reduce coronary heart disease (CHD)...
  50. doi Impact of multiple alcohol dehydrogenase gene polymorphisms on risk of upper aerodigestive tract cancers in a Japanese population
    Isao Oze
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Epidemiol Biomarkers Prev 18:3097-102. 2009
    ..In Caucasians, significant associations between polymorphisms in ADH1B (rs1229984) and ADH1C (rs698 and rs1693482), and UAT cancer have been observed, despite strong linkage disequilibrium among them...
  51. ncbi Influence of alcohol dehydrogenase 1C polymorphism on the alcohol-cardiovascular disease association (from the Framingham Offspring Study)
    Luc Djousse
    Section of Preventive Medicine and Epidemiology, Evans Department of Medicine, Boston University, Boston, MA, USA
    Am J Cardiol 96:227-32. 2005
    ..is associated with a lower risk of cardiovascular disease (CVD), little is known of the effects of alcohol dehydrogenase 1C (ADH1C) polymorphism on the association between alcohol and CVD...
  52. ncbi Genetic variation in alcohol dehydrogenase 1C and the beneficial effect of alcohol intake on coronary heart disease risk in the Second Northwick Park Heart Study
    Jenan Younis
    Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Rayne Building, Royal Free and University College Medical School, 5 University Street, London WC1E 6JF, UK
    Atherosclerosis 180:225-32. 2005
    b>Alcohol dehydrogenase 1C (ADH1C or ADH3) genotype reportedly modifies the association between alcohol consumption and coronary heart disease (CHD) risk, as well as influencing plasma high-density lipoprotein (HDL) levels [Hines LM, ..
  53. ncbi The role of acetaldehyde in upper digestive tract cancer in alcoholics
    Helmut K Seitz
    Department of Medicine and Laboratory of Alcohol Research, Liver Disease and Nutrition, Salem Medical Centre, Heidelberg, Germany
    Transl Res 149:293-7. 2007
    ..In Caucasians, alcohol dehydrogenase 1*1 (ADH1C*1) allele encodes for an alcohol dehydrogenase (ADH) isoenzyme, which produces 2...
  54. ncbi Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis
    Y C Chao
    Department of Internal Medicine, Tri Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China
    Am J Gastroenterol 95:2958-64. 2000
    ..The aim of this study was to investigate the differences among Chinese alcoholic patients with esophageal cancer, acute pancreatitis, and liver cirrhosis by studying the genetic polymorphisms of ADH2, ADH3, ALDH2, and P4502E1.
  55. ncbi Cutaneous metabolism of glycol ethers
    David J Lockley
    Skin Toxicology Group, Department of Environmental and Occupational Medicine, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    Arch Toxicol 79:160-8. 2005
    ..Although ADH1, ADH2 and ADH3 are expressed at the protein level in rat liver, only ADH1 and ADH2 are selectively inhibited by pyrazole and they ..
  56. ncbi Methanol metabolism and embryotoxicity in rat and mouse conceptuses: comparisons of alcohol dehydrogenase (ADH1), formaldehyde dehydrogenase (ADH3), and catalase
    Craig Harris
    Toxicology Program, Department of Environmental Health Sciences, School of Public Health, University of Michigan, 1420 Washington Heights, Ann Arbor, MI 48109 2029, USA
    Reprod Toxicol 17:349-57. 2003
    ..HCHO) and formic acid (HCOOH) by the enzymes alcohol dehydrogenase (ADH1), formaldehyde dehydrogenase (ADH3), and catalase may contribute to the observed species sensitivity...
  57. pmc Temporal expression of the human alcohol dehydrogenase gene family during liver development correlates with differential promoter activation by hepatocyte nuclear factor 1, CCAAT/enhancer-binding protein alpha, liver activator protein, and D-element-bindi
    C van Ooij
    Department of Biochemistry, Colorado State University, Fort Collins 80523
    Mol Cell Biol 12:3023-31. 1992
    The human class I alcohol dehydrogenase (ADH) gene family consists of ADH1, ADH2, and ADH3, which are sequentially activated in early fetal, late fetal, and postnatal liver, respectively...
  58. ncbi Characterization of alcohol dehydrogenase 1 and 3 from Neurospora crassa FGSC2489
    Yong Cheol Park
    Department of Biochemistry and Cell Biology, Rice University, 6100 Main St, Houston, TX 77005, USA
    Appl Microbiol Biotechnol 76:349-56. 2007
    ..Some also catalyze the formation of carboxylate esters from alcohols and aldehydes. The ADH1 and ADH3 genes of Neurospora crassa FGSC2489 were cloned and expressed in recombinant Escherichia coli to investigate their ..
  59. ncbi Methylenetetrahydrofolate reductase, alcohol dehydrogenase, diet, and risk of colorectal adenomas
    Edward Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 12:970-9. 2003
    ..and MTHFR 1298A-->C (gln-->ala)] (associated with reduced MTHFR activity) and in alcohol dehydrogenase 3 [ADH3 (2-2) associated with decreased alcohol catabolism] in relation to risk of colorectal adenoma in the Health ..
  60. doi Reduction of S-nitrosoglutathione by alcohol dehydrogenase 3 is facilitated by substrate alcohols via direct cofactor recycling and leads to GSH-controlled formation of glutathione transferase inhibitors
    Claudia A Staab
    Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Biochem J 413:493-504. 2008
    ..The present study explored ADH3 (alcohol dehydrogenase 3) in its dual function as GSNOR (GSNO reductase) and glutathione-dependent formaldehyde ..
  61. doi Oikopleura dioica alcohol dehydrogenase class 3 provides new insights into the evolution of retinoic acid synthesis in chordates
    Cristian Canestro
    Institute of Neuroscience, University of Oregon, Eugene, OR 97403, USA
    Zoolog Sci 27:128-33. 2010
    ..Among MDR-Adh enzymes, Adh3 is the only member present in non-vertebrates, and whether Adh3 is actually involved in RA biosynthesis remains ..
  62. pmc Heterogeneous geographic patterns of nucleotide sequence diversity between two alcohol dehydrogenase genes in wild barley (Hordeum vulgare subspecies spontaneum)
    J Z Lin
    Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA
    Proc Natl Acad Sci U S A 98:531-6. 2001
    ..subspecies spontaneum (wild barley) are compared between the putative alcohol dehydrogenase 3 locus (denoted "adh3") and alcohol dehydrogenase 1 (adh1), two related but unlinked loci...
  63. ncbi Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1
    E Borras
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Hepatology 31:984-9. 2000
    Polymorphism at the ADH2 and ADH3 loci of alcohol dehydrogenase (ADH) has been shown to have an effect on the predisposition to alcoholism in Asian individuals. However, the results are not conclusive for white individuals...
  64. ncbi Differential activity of the promoter for the human alcohol dehydrogenase (retinol dehydrogenase) gene ADH3 in neural tube of transgenic mouse embryos
    M Zgombic-Knight
    Cancer Research Center, La Jolla Cancer Research Foundation, California 92037
    J Biol Chem 269:6790-5. 1994
    ..pattern for one member of the human ADH family, we have constructed transgenic mouse lines carrying the human ADH3 promoter fused to the lacZ gene. ADH3-lacZ transgene expression was first noted at embryonic day 9...
  65. ncbi Excessive vitamin A toxicity in mice genetically deficient in either alcohol dehydrogenase Adh1 or Adh3
    Andrei Molotkov
    Gene Regulation Program, Burnham Institute, La Jolla, CA 92037, USA
    Eur J Biochem 269:2607-12. 2002
    ..Here, Adh1, Adh3, and Adh4 null mutant mice have been examined following acute and chronic vitamin A excess...
  66. ncbi Alcohol dehydrogenase genes: restriction fragment length polymorphisms for ADH4 (pi-ADH) and ADH5 (chi-ADH) and construction of haplotypes among different ADH classes
    K Edman
    Center for Biochemical and Biophysical Sciences and Medicine, Harvard Medical School, Boston, MA 02115
    Hum Genet 90:395-401. 1992
    ..Pairwise linkage disequilibrium calculations for these new RFLPs and already known RFLPs at the ADH2 and ADH3 loci establish strong linkage disequilibria between polymorphic MspI and BstXI sites in the ADH5 gene as well as ..
  67. ncbi Specificity of human alcohol dehydrogenase 1C*2 (gamma2gamma2) for steroids and simulation of the uncompetitive inhibition of ethanol metabolism
    Bryce V Plapp
    Department of Biochemistry, The University of Iowa, Iowa City, IA 52242 1109, USA
    Chem Biol Interact 143:183-93. 2003
    ..None of the reactive steroids has a known function in vivo. The activities with the human ADH1C*2 are <10% of those found with the recombinant horse ADH1S, but higher than the activities with recombinant ..
  68. ncbi Genetic associations of alcohol and aldehyde dehydrogenase with alcohol dependence and their mechanisms of action
    Tamara L Wall
    Department of Psychiatry, University of California and the Psychology Service, Veterans Affairs San Diego Healthcare System 92161, USA
    Ther Drug Monit 27:700-3. 2005
    Two alcohol dehydrogenase genes (ADHIB and ADH1C on chromosome 4) and one aldehyde dehydrogenase gene (ALDH2 on chromosome 12) exhibit functional polymorphisms that are associated with lower rates of alcohol dependence...
  69. pmc Major differences exist in the function and tissue-specific expression of human aflatoxin B1 aldehyde reductase and the principal human aldo-keto reductase AKR1 family members
    T O'CONNOR
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, U K
    Biochem J 343:487-504. 1999
    Complementary DNA clones encoding human aflatoxin B(1) aldehyde reductase (AKR7A2), aldehyde reductase (AKR1A1), aldose reductase (AKR1B1), dihydrodiol dehydrogenase 1 (AKR1C1) and chlordecone reductase (AKR1C4) have been expressed in ..
  70. ncbi Alcohol, tobacco and genetic susceptibility in relation to cancers of the upper aerodigestive tract in northern Italy
    Cristina Canova
    Department of Environmental Medicine and Public Health, University of Padua, Italy
    Tumori 96:1-10. 2010
    ..The study of single nucleotide polymorphisms in upper aerodigestive tract cancer etiology may help to identify high-risk subgroups and to better understand the pathways leading to the development of these cancers...
  71. ncbi Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma
    Akira Yokoyama
    National Institute on Alcoholism, Kurihama National Hospital, Yokosuka, Kanagawa 239 0841, Japan
    Carcinogenesis 23:1851-9. 2002
    The genetic polymorphisms of aldehyde dehydrogenase-2 (ALDH2), alcohol dehydrogenase-2 (ADH2), ADH3, and glutathione S-transferase M1 (GSTM1) influence the metabolism of alcohol and other carcinogens...
  72. pmc The intra- and extracellular proteome of Aspergillus niger growing on defined medium with xylose or maltose as carbon substrate
    Xin Lu
    Helmholtz Center for Infection Research, Inhoffenstr, Braunschweig, Germany
    Microb Cell Fact 9:23. 2010
    ..13 growing on defined medium with xylose or maltose as carbon substrate was carried out using 2-D gel electrophoresis/Maldi-ToF and nano-HPLC MS/MS...
  73. ncbi Genetic polymorphism of alcohol-metabolizing enzyme and alcohol dependence in Polish men
    H Cichoz-Lach
    Department of Gastroenterology, Medical University of Lublin, Poland
    Braz J Med Biol Res 43:257-61. 2010
    ..investigate the differences, if present, in the allele and genotype frequency of alcohol dehydrogenase 1B (ADH1B), ADH1C and the microsomal ethanol-oxidizing system (MEOS/CYP2E1) between alcohol-dependent individuals and controls and ..
  74. pmc Regulation of aflatoxin B1-metabolizing aldehyde reductase and glutathione S-transferase by chemoprotectors
    L I McLellan
    Department of Clinical Biochemistry, University of Edinburgh, Royal Infirmary, U K
    Biochem J 300:117-24. 1994
    ..In addition, the effect of these drugs on the hepatic levels of an aldehyde reductase (AFB1-AR) that metabolizes the cytotoxic dialdehydic form of AFB1 has been studied as this enzyme also ..
  75. ncbi Association of the ADH2*3 allele with a negative family history of alcoholism in African American young adults
    C L Ehlers
    Department of Neuropharmacology, The Scripps Research Institute, LaJolla, California, USA
    Alcohol Clin Exp Res 25:1773-7. 2001
    Two of the class I alcohol dehydrogenase (ADH) genes (ADH2 and ADH3) encode for multiple isozymes that differ in their kinetic properties...
  76. ncbi Molecular and metabolic retinoid pathways in the human ocular surface
    Hachemi Nezzar
    Universite d Auvergne, JE 2447, ARDEMO, France
    Mol Vis 13:1641-50. 2007
    ..The second objective was to demonstrate the presence of different enzymes transforming vitamin A to retinoic acid and the functionality of this metabolic pathway in the corneal epithelium...
  77. ncbi Tetrahydrobiopterin is synthesized from 6-pyruvoyl-tetrahydropterin by the human aldo-keto reductase AKR1 family members
    Teruhiko Iino
    Department of General Studies, Nihon University, Sakurajosui 3 25 40, Setagaya Ku, Tokyo 156 8550, Japan
    Arch Biochem Biophys 416:180-7. 2003
    ..by 3 alpha-hydroxysteroid dehydrogenase type 2, whereas 1(')-OXPH(4) was produced by aldose reductase, aldehyde reductase, and 20 alpha-hydroxysteroid dehydrogenase, and both 1(')-OXPH(4) and 2(')-OXPH(4) were detected as the ..
  78. ncbi Vitamin C. Biosynthesis, recycling and degradation in mammals
    Carole L Linster
    Universite Catholique de Louvain, Christian de Duve Institute of Cellular Pathology, Brussels, Belgium
    FEBS J 274:1-22. 2007
    ..Glucuronate is converted to l-gulonate by aldehyde reductase, an enzyme of the aldo-keto reductase superfamily...
  79. ncbi Regulation of rat glutathione S-transferase A5 by cancer chemopreventive agents: mechanisms of inducible resistance to aflatoxin B1
    J D Hayes
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Chem Biol Interact 111:51-67. 1998
    ..In addition to GSTA5, we have identified a novel aflatoxin-aldehyde reductase (AFAR) that is similarly induced by ethoxyquin...
  80. ncbi Resistance to aflatoxin B1 is associated with the expression of a novel aldo-keto reductase which has catalytic activity towards a cytotoxic aldehyde-containing metabolite of the toxin
    J D Hayes
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, United Kingdom
    Cancer Res 53:3887-94. 1993
    ..Therefore, this inducible enzyme has been designated aflatoxin B1-aldehyde reductase (AFB1-AR)...
  81. ncbi Molecular epidemiological studies in 1,3-butadiene exposed Czech workers: female-male comparisons
    Richard J Albertini
    BioMosaics, Inc, 665 Spear Street, Burlington, VT 05401, USA
    Chem Biol Interact 166:63-77. 2007
    ..GSTT1, CYP2E1 (5' promoter), CYP2E1 (intron 6), EH [epoxide hydrolase] 113, EH139, ADH [alcohol dehydrogenase]2 and ADH3). The no observed adverse effect level (NOAEL) for chromosome aberrations and HPRT mutations was 1.794 mg/m(3) (0...
  82. doi The role of aryl hydrocarbon receptor in regulation of enzymes involved in metabolic activation of polycyclic aromatic hydrocarbons in a model of rat liver progenitor cells
    Jan Vondracek
    Department of Cytokinetics, Institute of Biophysics ASCR, Brno, Czech Republic
    Chem Biol Interact 180:226-37. 2009
    ..In contrast, the aldehyde reductase AKR1A1 was not induced by either treatment...
  83. ncbi Aldose reductase: an aldehyde scavenging enzyme in the intraneuronal metabolism of norepinephrine in human sympathetic ganglia
    Minoru Kawamura
    Clinical Neurocardiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Auton Neurosci 96:131-9. 2002
    ..Although similar formation of DHPG was observed with human liver aldehyde reductase, the production of DHPG was more effective with aldose reductase than aldehyde reductase...
  84. doi Quantification of urinary aflatoxin B1 dialdehyde metabolites formed by aflatoxin aldehyde reductase using isotope dilution tandem mass spectrometry
    Denise N Johnson
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Chem Res Toxicol 21:752-60. 2008
    ..This urinary detection of the alcohol products directly contributes to the goal of mass balancing the fate of the bioreactive 8,9-epoxides of AFB 1 in vivo...
  85. ncbi Characterization of the rat aflatoxin B1 aldehyde reductase gene, AKR7A1. Structure and chromosomal localization of AKR7A1 as well as identification of antioxidant response elements in the gene promoter
    Elizabeth M Ellis
    Department of Bioscience and Pharmaceutical Sciences, University of Strathclyde, Glasgow G1 1XW, UK
    Carcinogenesis 24:727-37. 2003
    Rat aflatoxin B(1) aldehyde reductase (called AFAR1 or AKR7A1) is a member of the aldo-keto reductase 7 family, which metabolizes the environmental carcinogen aflatoxin B(1)...
  86. pmc Novel homodimeric and heterodimeric rat gamma-hydroxybutyrate synthases that associate with the Golgi apparatus define a distinct subclass of aldo-keto reductase 7 family proteins
    Vincent P Kelly
    Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Scotland, UK
    Biochem J 366:847-61. 2002
    The aldo-keto reductase (AKR) 7 family is composed of the dimeric aflatoxin B(1) aldehyde reductase (AFAR) isoenzymes. In the rat, two AFAR subunits exist, designated rAFAR1 and rAFAR2...
  87. ncbi Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase
    C J Winters
    Department of Medicine, Medical College of Virginia, Richmond 23298
    Biochemistry 29:1080-7. 1990
    ..The deduced protein sequence of CDR showed 65% similarity to the primary structure of human liver aldehyde reductase and 66% similarity to the inferred protein sequence of rat lens aldose reductase...
  88. ncbi Cloning of the human aflatoxin B1-aldehyde reductase gene at 1p35-1p36.1 in a region frequently altered in human tumor cells
    C Praml
    Division of Cytogenetics, Deutsches Krebsforschungszentrum, Heidelberg, Germany
    Cancer Res 58:5014-8. 1998
    ..a gene encoding a protein of 330 amino acids that is 78% identical with the Rattus norvegicus aflatoxin B1 aldehyde reductase (Afar) and, therefore, likely represents its human homologue...
  89. ncbi Enzymes in pancreatic islets that use NADP(H) as a cofactor including evidence for a plasma membrane aldehyde reductase
    M Laclau
    University of Wisconsin Childrens Diabetes Center, Madison, USA
    Mol Cell Biochem 225:151-60. 2001
    ..Significant activities of glutathione reductase, aldose reductase (EC.1.1.1.21) and aldehyde reductase (EC.1.1.1.2) were present in islets...
  90. pmc Enzymes of glycerol and glyceraldehyde metabolism in mouse liver: effects of caloric restriction and age on activities
    Kevork Hagopian
    Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Biosci Rep 28:107-15. 2008
    ..Aldehyde dehydrogenase and aldehyde reductase activities in both young and old CR mice were unchanged by caloric restriction...
  91. ncbi Molecular cloning and expression of an abundant rabbit ovarian protein with 20 alpha-hydroxysteroid dehydrogenase activity
    W R Lacy
    Department of Cell Biology, Baylor College of Medicine Houston, Texas 77030
    Mol Endocrinol 7:58-66. 1993
    ..to human chlordecone reductase, bovine lung prostaglandin F synthase, human aldose reductase, human aldehyde reductase, and frog lens rho-crystallin, placing rabbit ovarian 20 alpha HSD in the aldo-keto reductase family of ..
  92. ncbi Purification and characterization of human testis aldose and aldehyde reductase
    T Tanimoto
    Division of Biological Chemistry, National Institute of Hygienic Sciences, Tokyo, Japan
    Int J Biochem 23:421-8. 1991
    1. Aldose reductase and aldehyde reductase were purified to homogeneity from human testis. 2...
  93. pmc Protection against aflatoxin B1-induced cytotoxicity by expression of the cloned aflatoxin B1-aldehyde reductases rat AKR7A1 and human AKR7A3
    Sridevi Bodreddigari
    Department of Biology and W Harry Feinstone Center for Genomic Research, University of Memphis, Memphis, Tennessee 38152, USA
    Chem Res Toxicol 21:1134-42. 2008
    ..B 1 (AFB 1) dialdehyde metabolite to its corresponding mono and dialcohols, catalyzed by aflatoxin B 1-aldehyde reductase (AFAR, rat AKR7A1, and human AKR7A3), is greatly increased in livers of rats treated with numerous ..
  94. pmc A new view of alcohol metabolism and alcoholism--role of the high-Km Class III alcohol dehydrogenase (ADH3)
    Takeshi Haseba
    Department of Legal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo, Japan
    Int J Environ Res Public Health 7:1076-92. 2010
    ..Recently, using ADH3-null mutant mice, we demonstrated that ADH3 (Class III), which has a high K(m) and is a ubiquitous enzyme of ..
  95. pmc Transgenic expression of aflatoxin aldehyde reductase (AKR7A1) modulates aflatoxin B1 metabolism but not hepatic carcinogenesis in the rat
    Bill D Roebuck
    Department of Pharmacology and Toxicology, Dartmouth Medical School, Hanover, New Hampshire 03755, USA
    Toxicol Sci 109:41-9. 2009
    ..These results imply that the prevention of protein adducts mediated by AKR are not critical to protection against AFB(1) tumorigenicity...
  96. ncbi [A new sight on alcohol metabolism and alcoholism--role of high Km alcohol dehydrogenase ADH3 (Class III)]
    Takeshi Haseba
    Department of Legal Medicine, Nippon Medical School, 1 1 5 Sendagi, Bunkyo ku, Tokyo 113 8602, Japan
    Nihon Arukoru Yakubutsu Igakkai Zasshi 44:78-93. 2009
    ..Recently, we used ADH3-null mutant mice to demonstrate that high Km ADH3 (Class III), a ubiquitous enzyme of ancient origin, contributes ..
  97. ncbi Characterization of a monoclonal antibody for human aldo-keto reductase AKR1C3 (type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase); immunohistochemical detection in breast and prostate
    Hsueh Kung Lin
    Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19018, USA
    Steroids 69:795-801. 2004
    ..It does not cross react with human AKR1C1, AKR1C2 or AKR1C4, human aldehyde reductase AKR1A1 or rat 3alpha-hydroxysteroid dehydrogenase (AKR1C9) on immunoblot analysis...
  98. ncbi Purification and characterization of a novel cytosolic NADP(H)-dependent retinol oxidoreductase from rabbit liver
    D Y Huang
    Department of Biochemistry, School of Medicine, Kagawa Medical University, Japan
    Biochim Biophys Acta 1338:47-59. 1997
    ..This enzyme exhibits relatively broad aldehyde reductase activity and some ketone reductase activity, the activity for aromatic substitutive aldehydes being ..
  99. pmc A novel aldehyde reductase with activity towards a metabolite of aflatoxin B1 is expressed in rat liver during carcinogenesis and following the administration of an anti-oxidant
    D J Judah
    MRC Toxicology Unit, Carshalton, Surrey, U K
    Biochem J 292:13-8. 1993
    In contrast with fractions from control animals, an aldehyde reductase, which catalyses the reduction of aflatoxin B1-dihydrodiol, in the dialdehyde form at physiological pH values, to aflatoxin B1-dialcohol, is expressed in cytosolic ..
  100. ncbi Cloning and expression of two novel aldo-keto reductases from Digitalis purpurea leaves
    Isabel Gavidia
    Center of Plant Molecular Biology ZMBP, University of Tubingen, Germany
    Eur J Biochem 269:2842-50. 2002
    ..proteins present high identities (68-80%) with four Arabidopsis clones and a 67% identity with the aldose/aldehyde reductase from Medicago sativa...
  101. pmc Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog
    K Watanabe
    Hayaishi Bioinformation Transfer Project, Kyoto Laboratory, Research Development Corporation of Japan
    Proc Natl Acad Sci U S A 85:11-5. 1988
    ..that bovine lung PGF synthase shows 62% identical plus conservative substitutions compared with human liver aldehyde reductase [Wermuth, B., Omar, A., Forster, A., Francesco, C., Wolf, M., Wartburg, J.P., Bullock, B. & Gabbay, K.H...

Research Grants66

  1. Molecular Mechanisms of Multistage Carcinogenesis
    TREVOR PENNING; Fiscal Year: 2006
    ..Project # 1 (Dr. Penning) will compare the roles of human aldehyde reductase (AKR1A1), CYP1A1/CYP1B1, and CYP-peroxidase in the metabolic activation of PAH using a stable expression ..
  2. Alcohol-Metabolizing Gene Variation, Lipids, Hemostatic Factors and CVD
    Kelly Volcik; Fiscal Year: 2007
    ..sixteen functional and/or non-synonymous variants in the class I and II alcohol dehydrogenase genes (ADH1B, ADH1C, ADH4), the aldehyde dehydrogenase genes (ALDH1, ALDH2) and the cytochrome P4502E1 gene (CYP2E1), all of which are ..
  3. ALCOHOL PHARMACOGENETICS IN MEXICAN AMERICANS
    YU JUI WAN; Fiscal Year: 2007
    ..for both ALDH2*2 (aldehyde dehydrogenase) and ADH2*2 (alcohol dehydrogenase); (2) a relatively high rate of ADH3*2 and CYP2E1 c2 (cytochrome P4502E1) alleles; (3) association of ADH3*2, ADH2*1, DRD2 (dopamine receptor -141C Del/..
  4. ALCOHOL PHARMACOGENETICS IN MEXICAN AMERICANS
    YU JUI WAN; Fiscal Year: 2009
    ..for both ALDH2*2 (aldehyde dehydrogenase) and ADH2*2 (alcohol dehydrogenase); (2) a relatively high rate of ADH3*2 and CYP2E1 c2 (cytochrome P4502E1) alleles; (3) association of ADH3*2, ADH2*1, DRD2 (dopamine receptor -141C Del/..
  5. ALCOHOL METABOLISM GENES IN TRANSGENIC MICE
    Michael Felder; Fiscal Year: 2007
    ..in the liver of mammals A single gene, Adh1, encodes class I ADH in mice while three genes, ADH1A, ADH1B and ADH1C, encode class I polypeptides in humans The overall goals are to identify distal genomic dements that control the ..
  6. Genetic Factors and Cardiovascular Disease
    Luc Djousse; Fiscal Year: 2005
    ..We will use data collected on Framingham Offspring participants to test 1) whether variants of ADH3 genotypes modify the association between alcohol intake and CHD, HDL-cholesterol, frequency, amount, and type of ..
  7. Protein Modification by 3,4-Dihydroxyphenylacetaldehyde
    JONATHAN DOORN; Fiscal Year: 2006
    ..metabolized primarily to an acid via mitochondrial aldehyde dehydrogenase (ALDH2) but also to an alcohol by aldehyde reductase (ALR). Recent work implicates oxidative stress and lipid peroxidation products, e.g...
  8. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen Hecht; Fiscal Year: 2007
    ..2a. Determine the influence of polymorphisms in alcohol dehydrogenase (ADH1C) and aldehyde dehydrogenase (ALDH2) genes on levels of adduct 1 in leukocyte DNA of non-smokers who consume ..
  9. DNA Adducts of the Carcinogen Acetaldehyde
    Stephen S Hecht; Fiscal Year: 2010
    ..2a. Determine the influence of polymorphisms in alcohol dehydrogenase (ADH1C) and aldehyde dehydrogenase (ALDH2) genes on levels of adduct 1 in leukocyte DNA of non-smokers who consume ..
  10. ALDO-KETO REDUCTASES AS PART OF CHEMICAL STRESS RESPONSE
    Oleg Barski; Fiscal Year: 2002
    ..Recently it was shown that ethoxyquin and antiobiotic tunicamycin also induce aldehyde reductase, another member of the aldo-keto reductase family...
  11. CARDIAC METABOLISM OF ENALS
    Aruni Bhatnagar; Fiscal Year: 2009
    ..Our studies show that in the heart enals are metabolized by aldose reductase (AR), aldehyde reductase, and glutathione-S-transferases...
  12. CARDIAC METABOLISM OF ENALS
    ARUNI BHATNAGAR BHATNAGAR; Fiscal Year: 2010
    ..Our studies show that in the heart enals are metabolized by aldose reductase (AR), aldehyde reductase, and glutathione-S-transferases...
  13. INTRACELLULAR GLYCATION AND DIABETIC COMPLICATIONS
    Michael Brownlee; Fiscal Year: 2000
    ..The activities of aldehyde reductase, aldose reductase, dihydrodiol dehydrogenase and glyoxalase I will be assessed in primary Muller cells...
  14. Electrostatics and Dynamics in Proteins
    STEVEN BOXER; Fiscal Year: 2009
    ..probe time-averaged and time-dependent electric fields in several enzymes: human aldose reductase and human aldehyde reductase (Sub-Aim 1A), both important to the control of diabetes, and ketosteroid isomerase (Sub-Aim 1B)...
  15. Electrostatics and Dynamics in Proteins
    Steven G Boxer; Fiscal Year: 2010
    ..probe time-averaged and time-dependent electric fields in several enzymes: human aldose reductase and human aldehyde reductase (Sub-Aim 1A), both important to the control of diabetes, and ketosteroid isomerase (Sub-Aim 1B)...
  16. ALDOSE REDUCTASE AND DIABETIC COMPLICATIONS
    SATISH SRIVASTAVA; Fiscal Year: 1993
    ..In addition, all the ARIs presently known inhibit both AR and aldehyde reductase, and both enzymes have overlapping substrate specificities...
  17. Vibrational Stark Effect in Human Aldose Reductase
    LAUREN WEBB; Fiscal Year: 2007
    ..One key to finding strong inhibitors of hALR2 that do not also bind to a structurally similar protein, human aldehyde reductase (hALR1), is to measure the electrostatic field of the inhibitor binding site...
  18. Folate, Vitamin D and Calcium in Colorectal Cancer
    Robert Haile; Fiscal Year: 2009
    ..factor (GIF), transcobalamin II (TCII), intrinsic factor cobalamin receptor (IFCR), and alcohol dehydrogenase 3 (ADH3). Vitamin D and Calcium...
  19. Folate, Vitamin D and Calcium in Colorectal Cancer
    Robert Haile; Fiscal Year: 2007
    ..factor (GIF), transcobalamin II (TCII), intrinsic factor cobalamin receptor (IFCR), and alcohol dehydrogenase 3 (ADH3). Vitamin D and Calcium...