ADGRE5

Summary

Gene Symbol: ADGRE5
Description: adhesion G protein-coupled receptor E5
Alias: CD97, TM7LN1, CD97 antigen, CD97 molecule, leukocyte antigen CD97, seven transmembrane helix receptor, seven-span transmembrane protein, seven-transmembrane, heterodimeric receptor associated with inflammation
Species: human
Products:     ADGRE5

Top Publications

  1. Wandel E, Saalbach A, Sittig D, Gebhardt C, Aust G. Thy-1 (CD90) is an interacting partner for CD97 on activated endothelial cells. J Immunol. 2012;188:1442-50 pubmed publisher
    ..In this study, we characterized the adhesion G-protein coupled receptor CD97, present on peripheral myeloid cells, as a novel interacting partner for Thy-1...
  2. Lin H, Stacey M, Saxby C, Knott V, Chaudhry Y, Evans D, et al. Molecular analysis of the epidermal growth factor-like short consensus repeat domain-mediated protein-protein interactions: dissection of the CD97-CD55 complex. J Biol Chem. 2001;276:24160-9 pubmed
    ..We have dissected the binding of CD97 (a member of the EGF-TM7 family) to the complement regulator CD55, two cell surface modular proteins that contain ..
  3. Liu Y, Chen L, Peng S, Chen Z, Gimm O, Finke R, et al. The expression of CD97EGF and its ligand CD55 on marginal epithelium is related to higher stage and depth of tumor invasion of gastric carcinomas. Oncol Rep. 2005;14:1413-20 pubmed
    ..Expression of CD97(EGF) in the margins showed a marked difference between the depth of tumor invasion T1 and T2, 3 and 4, and stages I ..
  4. Stacey M, Chang G, Davies J, Kwakkenbos M, Sanderson R, Hamann J, et al. The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans. Blood. 2003;102:2916-24 pubmed
    ..The largest isoform of CD97, a related EGF-TM7 molecule containing an identical EGF-like module, also binds to the putative EMR2 ligand...
  5. Kwakkenbos M, Kop E, Stacey M, Matmati M, Gordon S, Lin H, et al. The EGF-TM7 family: a postgenomic view. Immunogenetics. 2004;55:655-66 pubmed
    ..Recent in vivo studies demonstrate a role of the EGF-TM7 receptor CD97 in leukocyte migration...
  6. Wobus M, Huber O, Hamann J, Aust G. CD97 overexpression in tumor cells at the invasion front in colorectal cancer (CC) is independently regulated of the canonical Wnt pathway. Mol Carcinog. 2006;45:881-6 pubmed
    ..Overexpression of CD97, a molecule that correlates with dedifferentiation and tumor stage in CC, parallels to nuclear translocation of ..
  7. Gray J, Haino M, Roth M, Maguire J, Jensen P, Yarme A, et al. CD97 is a processed, seven-transmembrane, heterodimeric receptor associated with inflammation. J Immunol. 1996;157:5438-47 pubmed
    b>CD97 is a receptor that spans the membrane seven times, a defining feature of G protein-coupled receptors...
  8. Aust G, Eichler W, Laue S, Lehmann I, Heldin N, Lotz O, et al. CD97: a dedifferentiation marker in human thyroid carcinomas. Cancer Res. 1997;57:1798-806 pubmed
    ..Phorbol 12-myristate 13-acetate treatment progressively caused a decrease of CD97 antigen expression in all cell lines to about 30% of their initial levels after 48 h...
  9. Poelkens F, Lammers G, Pardoel E, Tack C, Hopman M. Upregulation of skeletal muscle inflammatory genes links inflammation with insulin resistance in women with the metabolic syndrome. Exp Physiol. 2013;98:1485-94 pubmed publisher
    ..most significantly upregulated of this group, interleukin 6 receptor (IL6R), histone deacetylase 9 (HDAC9) and CD97 molecule (CD97), were significantly correlated with insulin resistance...

More Information

Publications67

  1. Qian Y, Haino M, Kelly K, Song W. Structural characterization of mouse CD97 and study of its specific interaction with the murine decay-accelerating factor (DAF, CD55). Immunology. 1999;98:303-11 pubmed
    b>CD97 is a newly identified, activation-associated human leucocyte antigen with seven putative transmembrane domains...
  2. Liu D, Trojanowicz B, Ye L, Li C, Zhang L, Li X, et al. The invasion and metastasis promotion role of CD97 small isoform in gastric carcinoma. PLoS ONE. 2012;7:e39989 pubmed publisher
    b>CD97 is over-expressed in the majority of gastric adenocarcinomas and is associated with its dedifferentiation and aggressiveness...
  3. Han S, Xu C, Wu X, Li J, Liu Z, Zeng Q. The impact of expressions of CD97 and its ligand CD55 at the invasion front on prognosis of rectal adenocarcinoma. Int J Colorectal Dis. 2010;25:695-702 pubmed publisher
    Various evidence show that CD97 plays an important role in tumor differentiation, migration, invasiveness, and metastasis by binding its cellular ligand CD55...
  4. Visser L, de Vos A, Hamann J, Melief M, van Meurs M, van Lier R, et al. Expression of the EGF-TM7 receptor CD97 and its ligand CD55 (DAF) in multiple sclerosis. J Neuroimmunol. 2002;132:156-63 pubmed
    b>CD97 is a recently identified seven-span transmembrane (7-TM) protein that is expressed by leukocytes early after activation...
  5. Safaee M, Clark A, Oh M, Ivan M, Bloch O, Kaur G, et al. Overexpression of CD97 confers an invasive phenotype in glioblastoma cells and is associated with decreased survival of glioblastoma patients. PLoS ONE. 2013;8:e62765 pubmed publisher
    ..b>CD97 is a member of the epidermal growth factor seven-span transmembrane family of adhesion G-protein coupled receptors...
  6. Hsiao C, Cheng K, Chen H, Chou Y, Stacey M, Chang G, et al. Site-specific N-glycosylation regulates the GPS auto-proteolysis of CD97. FEBS Lett. 2009;583:3285-90 pubmed publisher
    ..Here, we investigated the GPS proteolysis of CD97, a human leukocyte-restricted and tumor-associated adhesion-GPCR...
  7. Liu D, Trojanowicz B, Radestock Y, Fu T, Hammje K, Chen L, et al. Role of CD97 isoforms in gastric carcinoma. Int J Oncol. 2010;36:1401-8 pubmed
    The aim of this study was to elucidate the role of CD97 isoforms in gastric carcinoma. Out of four gastric cancer cell lines investigated, BGC-823 cells demonstrating low CD97 protein expression were stably transfected with pcDNA3...
  8. Wu J, Lei L, Wang S, Gu D, Zhang J. Immunohistochemical expression and prognostic value of CD97 and its ligand CD55 in primary gallbladder carcinoma. J Biomed Biotechnol. 2012;2012:587672 pubmed publisher
    b>CD97 as a member of the EGF-TM7 family with adhesive properties plays an important role in tumor aggressiveness by binding its cellular ligand CD55, which is a complement regulatory protein expressed by cells to protect them from ..
  9. Ward Y, Lake R, Yin J, Heger C, Raffeld M, Goldsmith P, et al. LPA receptor heterodimerizes with CD97 to amplify LPA-initiated RHO-dependent signaling and invasion in prostate cancer cells. Cancer Res. 2011;71:7301-11 pubmed publisher
    b>CD97, an adhesion-linked G-protein-coupled receptor (GPCR), is induced in multiple epithelial cancer lineages. We address here the signaling properties and the functional significance of CD97 expression in prostate cancer...
  10. Chidambaram A, Fillmore H, Van Meter T, Dumur C, Broaddus W. Novel report of expression and function of CD97 in malignant gliomas: correlation with Wilms tumor 1 expression and glioma cell invasiveness. J Neurosurg. 2012;116:843-53 pubmed publisher
    ..One candidate target, CD97, was then selected for further investigation into its role by suppressing its expression using siRNA silencing, ..
  11. Wang T, Ward Y, Tian L, Lake R, Guedez L, Stetler Stevenson W, et al. CD97, an adhesion receptor on inflammatory cells, stimulates angiogenesis through binding integrin counterreceptors on endothelial cells. Blood. 2005;105:2836-44 pubmed
    b>CD97, a membrane protein expressed at high levels on inflammatory cells and some carcinomas, is a member of the adhesion G protein-coupled receptor family, whose members have bipartite structures consisting of an extracellular peptide ..
  12. Kwakkenbos M, Pouwels W, Matmati M, Stacey M, Lin H, Gordon S, et al. Expression of the largest CD97 and EMR2 isoforms on leukocytes facilitates a specific interaction with chondroitin sulfate on B cells. J Leukoc Biol. 2005;77:112-9 pubmed
    The EGF-TM7 receptors CD97 and EMR2 are heptahelical molecules predominantly expressed on leukocytes...
  13. Steinert M, Wobus M, Boltze C, Schutz A, Wahlbuhl M, Hamann J, et al. Expression and regulation of CD97 in colorectal carcinoma cell lines and tumor tissues. Am J Pathol. 2002;161:1657-67 pubmed
    The expression of CD97, a member of the EGF-TM7 family with adhesive properties, is proportional to the aggressiveness and lymph node involvement in thyroid tumors. CD97 has never been systematically investigated in other tumors...
  14. Jaspars L, Vos W, Aust G, van Lier R, Hamann J. Tissue distribution of the human CD97 EGF-TM7 receptor. Tissue Antigens. 2001;57:325-31 pubmed
    b>CD97 is a founding member of the EGF-TM7 family of class II seven-span transmembrane (7-TM) receptors...
  15. Hamann J, Eichler W, Hamann D, Kerstens H, Poddighe P, Hoovers J, et al. Expression cloning and chromosomal mapping of the leukocyte activation antigen CD97, a new seven-span transmembrane molecule of the secretion receptor superfamily with an unusual extracellular domain. J Immunol. 1995;155:1942-50 pubmed
    b>CD97 is a monomeric glycoprotein of 75 to 85 kDa that is induced rapidly on the surface of most leukocytes upon activation. We herein report the isolation of a cDNA encoding human CD97 by expression cloning in COS cells...
  16. Hamann J, Vogel B, van Schijndel G, van Lier R. The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF). J Exp Med. 1996;184:1185-9 pubmed
    b>CD97 is an activation-induced antigen on leukocytes with a seven-span transmembrane (7-TM) region homologous to the secretin receptor superfamily...
  17. Hamann J, Hartmann E, van Lier R. Structure of the human CD97 gene: exon shuffling has generated a new type of seven-span transmembrane molecule related to the secretin receptor superfamily. Genomics. 1996;32:144-7 pubmed
    Recent cDNA cloning of EMR1 and CD97 suggests the existence of a new group of seven-span transmembrane (7-TM) molecules, likely encoded by a gene cluster on the short arm of chromosome 19...
  18. Ward Y, Lake R, Faraji F, Sperger J, Martin P, Gilliard C, et al. Platelets Promote Metastasis via Binding Tumor CD97 Leading to Bidirectional Signaling that Coordinates Transendothelial Migration. Cell Rep. 2018;23:808-822 pubmed publisher
    ..We identify a direct interaction between platelets and tumor CD97 that stimulates rapid bidirectional signaling...
  19. Ma C, Lv Q, Teng S, Yu Y, Niu K, Yi C. Identifying key genes in rheumatoid arthritis by weighted gene co-expression network analysis. Int J Rheum Dis. 2017;20:971-979 pubmed publisher
    ..These genes were enriched in totally enriched in 17 Gene Ontology terms, mainly related to immune response (CD97, FYB, CXCL1, IKBKE, CCR1, etc.), inflammatory response (CD97, CXCL1, C3AR1, CCR1, LYZ, etc...
  20. Saksa N, Neme A, Ryynänen J, Uusitupa M, de Mello V, Voutilainen S, et al. Dissecting high from low responders in a vitamin D3 intervention study. J Steroid Biochem Mol Biol. 2015;148:275-82 pubmed publisher
    ..In hematopoietic cells, the genes ASAP2, CAMP, CD14, CD97, DUSP10, G0S2, IL8, LRRC8A, NINJ1, NRIP1, SLC37A2 and THBD are known as primary vitamin D targets...
  21. Reig Ferrer A, Ferrer Cascales R, Santos Ruiz A, Campos Ferrer A, Prieto Seva A, Velasco Ruiz I, et al. A relaxation technique enhances psychological well-being and immune parameters in elderly people from a nursing home: a randomized controlled study. BMC Complement Altern Med. 2014;14:311 pubmed publisher
    ..Our findings reveal significant differences between the experimental and control groups in CD19, CD71, CD97, CD134, and CD137 lymphocyte subpopulations at the end of treatment...
  22. Taranu I, Braicu C, Marin D, Pistol G, Motiu M, Balacescu L, et al. Exposure to zearalenone mycotoxin alters in vitro porcine intestinal epithelial cells by differential gene expression. Toxicol Lett. 2015;232:310-25 pubmed publisher
    ..The up-regulation of CD97 gene and the down-regulation of tumour suppressor genes (DKK-1, PCDH11X and TC531386) demonstrates the carcinogenic ..
  23. Hilbig D, Sittig D, Hoffmann F, Rothemund S, Warmt E, Quaas M, et al. Mechano-Dependent Phosphorylation of the PDZ-Binding Motif of CD97/ADGRE5 Modulates Cellular Detachment. Cell Rep. 2018;24:1986-1995 pubmed publisher
    ..Here, we show that mechanical forces rapidly induce phosphorylation of CD97/ADGRE5 (pCD97) at its intracellular C-terminal PDZ-binding motif (PBM)...
  24. Tian H, Chen Y, Zhao J, Liu D, Liang G, Gong W, et al. [Effects of siRNAs targeting CD97 immune epitopes on biological behavior in breast cancer cell line MDA-MB231]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2017;46:341-348 pubmed
    To investigate the effects of siRNAs targeting CD97 immune epitopes on proliferation, infiltration, apoptosis and cell cycle of breast cancer cells...
  25. Singh V, Singh L, Vasudevan M, Chattopadhyay I, Borthakar B, Rai A, et al. Esophageal Cancer Epigenomics and Integrome Analysis of Genome-Wide Methylation and Expression in High Risk Northeast Indian Population. OMICS. 2015;19:688-99 pubmed publisher
    ..four genes (PTK2, RND1, RND3, and UBL3) with promoter hypermethylation and downregulation, and 19 genes (SEMG2, CD97, CTNND2, CADM3, OMD, NEFM, FBN2, CTNNB1, DLX6, UGT2B4, CCDC80, PZP, SERPINA4, TNFSF13B, NPC1, COL1A1, TAC3, BMP8A, ..
  26. Lewis S, Treacher D, Edgeworth J, Mahalingam G, Brown C, Mare T, et al. Expression of CD11c and EMR2 on neutrophils: potential diagnostic biomarkers for sepsis and systemic inflammation. Clin Exp Immunol. 2015;182:184-94 pubmed publisher
    ..study we determined whether the expression of known (CD11a/b/c, CD62L) and putative adhesion molecules [CD64, CD97 and epidermal growth factor (EGF)-like molecule containing mucin-like hormone receptor (EMR2)] on blood neutrophils ..
  27. Hamann J, Hsiao C, Lee C, Ravichandran K, Lin H. Adhesion GPCRs as Modulators of Immune Cell Function. Handb Exp Pharmacol. 2016;234:329-350 pubmed
    ..the ADGRE subfamily members EMR1 (F4/80, ADGRE1), EMR2 (ADGRE2), EMR3 (ADGRE3), EMR4 (FIRE, ADGRE4), and CD97 (ADGRE5), the ADGRB subfamily member BAI1 (ADGRB1), and the ADGRG subfamily members GPR56 (ADGRG1), GPR97 (Pb99, ADGRG3), ..
  28. Huang Y, Ollikainen M, Sipilä P, Mustelin L, Wang X, Su S, et al. Genetic and Environmental Effects on Gene Expression Signatures of Blood Pressure: A Transcriptome-Wide Twin Study. Hypertension. 2018;71:457-464 pubmed publisher
    ..systolic BP and MOK expression, and 100% of the phenotypic association of systolic and diastolic BP with CD97 (cluster of differentiation 97), TIPARP (TCDD-inducible poly[ADP-ribose] polymerase), and TPPP3 ..
  29. Aust G, Zhu D, Van Meir E, Xu L. Adhesion GPCRs in Tumorigenesis. Handb Exp Pharmacol. 2016;234:369-396 pubmed
    ..For example, ADGRE5 (CD97) and ADGRG1 (GPR56) show increased expression in many cancers, and initial functional studies suggest that ..
  30. Hsiao C, Keysselt K, Chen H, Sittig D, Hamann J, Lin H, et al. The Adhesion GPCR CD97/ADGRE5 inhibits apoptosis. Int J Biochem Cell Biol. 2015;65:197-208 pubmed publisher
    The Adhesion G protein-coupled receptor (GPCR) CD97/ADGRE5 is induced, upregulated, and/or biochemically modified in various malignancies, compared to the corresponding normal tissues...
  31. Lee Y, Wu C, Li J, Ou C, Hsu S, Tseng H, et al. A rational approach for cancer stem-like cell isolation and characterization using CD44 and prominin-1(CD133) as selection markers. Oncotarget. 2016;7:78499-78515 pubmed publisher
    ..PX1_133+44+ and OVCAR3.PX1_133+44+ cells uniquely expressed 5 CD markers (CD97, CD104, CD107a, CD121a, and CD125)...
  32. Baraka A, Sherief L, Kamal N, Shorbagy S. Detection of minimal residual disease in childhood B-acute lymphoblastic leukemia by 4-color flowcytometry. Int J Hematol. 2017;105:784-791 pubmed publisher
    ..established in 15 control participants using 4-four panels of monoclonal Antibodies (Mo Abs),{CD22, CD45, CD58 and CD97 in combination with CD10, CD19, CD34}...
  33. Akil A, Zhang Q, Mumaw C, Raiker N, Yu J, Velez de Mendizabal N, et al. Biomarkers for Diagnosis and Prognosis of Sinusoidal Obstruction Syndrome after Hematopoietic Cell Transplantation. Biol Blood Marrow Transplant. 2015;21:1739-45 pubmed publisher
    ..VCAM1], tissue inhibitor of metalloproteinase-1, von Willebrand factor, intercellular adhesion molecule-1, and CD97) based on a differential heavy/light isotope ratio of at least 2 fold, information from the literature, and ..
  34. Yeon Won H, Hwan Mun S, Shin B, Lee S. Contradictory Role of CD97 in Basal and Tumor Necrosis Factor-Induced Osteoclastogenesis In Vivo. Arthritis Rheumatol. 2016;68:1301-13 pubmed publisher
    b>CD97, a member of the 7-transmembrane epidermal growth factor family of adhesion G protein-coupled receptors, is expressed on various cell types...
  35. Meng Z, Liu M, Hong H, Du Q, Chen Y. Expression and prognostic value of soluble CD97 and its ligand CD55 in intrahepatic cholangiocarcinoma. Tumour Biol. 2017;39:1010428317694319 pubmed publisher
    ..Immunohistochemistry and enzyme-linked immunosorbent assay were applied to analyze the expressions of CD97, CD55, and soluble CD97 in 71 patients with intrahepatic cholangiocarcinoma and 10 patients with hepatolithiasis...
  36. Yang L, Liu X, Yang Y, Yang L, Liu K, Tang Y, et al. Biochemical features of the adhesion G protein-coupled receptor CD97 related to its auto-proteolysis and HeLa cell attachment activities. Acta Pharmacol Sin. 2017;38:56-68 pubmed publisher
    b>CD97 belongs to the adhesion GPCR family characterized by a long ECD linked to the 7TM via a GPCR proteolytic site (GPS) and plays important roles in modulating cell migration and invasion...
  37. Wobus M, Bornhäuser M, Jacobi A, Kräter M, Otto O, Ortlepp C, et al. Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia. Oncotarget. 2015;6:38804-15 pubmed publisher
    ..The expression of CD97, an EGF-TM7 receptor, has been linked to invasive behavior in thyroid and colorectal cancer...
  38. Hsiao C, Chen H, Chang G, Lin H. GPS autoproteolysis is required for CD97 to up-regulate the expression of N-cadherin that promotes homotypic cell-cell aggregation. FEBS Lett. 2011;585:313-8 pubmed publisher
    ..Here we show that GPS cleavage is essential for the homotypic cell aggregation promoted by CD97 receptor, a leukocyte-restricted adhesion-GPCR often aberrantly expressed in carcinomas...
  39. He Y, Wang W, Xu L, Li L, Liu J, Feng M, et al. Immunohistochemical Expression and Prognostic Significance of CD97 and its Ligand DAF in Human Cervical Squamous Cell Carcinoma. Int J Gynecol Pathol. 2015;34:473-9 pubmed publisher
    Accumulating evidences had demonstrated that the CD97, a member of the epidermal growth factor 7-transmembrane family, and its cellular ligand decay accelerating factor (DAF) both play important roles in tumor dedifferentiation, migration,..
  40. Li C, Liu D, Li G, Wang H, Li X, Zhang W, et al. CD97 promotes gastric cancer cell proliferation and invasion through exosome-mediated MAPK signaling pathway. World J Gastroenterol. 2015;21:6215-28 pubmed publisher
    To investigate the mechanism underlying the promoting role of CD97 in gastric cancer cell proliferation and invasion...
  41. Safaee M, Fakurnejad S, Bloch O, Clark A, Ivan M, Sun M, et al. Proportional upregulation of CD97 isoforms in glioblastoma and glioblastoma-derived brain tumor initiating cells. PLoS ONE. 2015;10:e0111532 pubmed publisher
    b>CD97 is a novel glioma antigen that confers an invasive phenotype and poor survival in patients with glioblastoma (GBM), the most aggressive primary malignant brain tumor...
  42. Chiu P, Ng B, Chang G, Gordon S, Lin H. Putative alternative trans-splicing of leukocyte adhesion-GPCR pre-mRNAs generates functional chimeric receptors. FEBS Lett. 2008;582:792-8 pubmed publisher
    ..of EMR2 transcripts identified unique fragments containing the EGF-like motif 3 of a closely related EGF-TM7 gene, CD97, in addition to the alternative cis-spliced products...
  43. Tian H, Chen Y, Zhao J, Liu D, Gong W, Chen L, et al. Effects of targeted CD97 immune epitopes small interference RNA on cellular biological behaviors in MDA-MB231 malignant breast cancer cell line. Am J Transl Res. 2017;9:4640-4651 pubmed
    Two CD97 immune epitopes, CD97EGF (epidermal growth factor domain) and CD97Stalk (stalk domain), have different distribution patterns in malignant epidermal tumors...
  44. Wobus M, Wandel E, Prohaska S, Findeiss S, Tschop K, Aust G. Transcriptional regulation of the human CD97 promoter by Sp1/Sp3 in smooth muscle cells. Gene. 2008;413:67-75 pubmed publisher
    The EGF-TM7 receptor CD97 shows different features of expression and function in muscle cells compared to hematopoetic and tumor cells...
  45. Shen Y, Best O, Mulligan S, Christopherson R. Ibrutinib and idelalisib block immunophenotypic changes associated with the adhesion and activation of CLL cells in the tumor microenvironment. Leuk Lymphoma. 2017;:1-11 pubmed publisher
    ..or idelalisib countered the change in expression of 11 of these antigens (CD23, CD27, CD53, CD58, CD71, CD80, CD84, CD97, CD126, CD150, and FMC7), which have known roles in cell activation and adhesion...
  46. van Eijk M, Aust G, Brouwer M, van Meurs M, Voerman J, Dijke I, et al. Differential expression of the EGF-TM7 family members CD97 and EMR2 in lipid-laden macrophages in atherosclerosis, multiple sclerosis and Gaucher disease. Immunol Lett. 2010;129:64-71 pubmed publisher
    ..Therefore, we determined the expression of CD97, EGF module-containing mucin-like receptor (EMR)2 and EMR3 by monocyte-derived macrophages experimentally polarized ..
  47. Ghannadan M, Baghestanian M, Wimazal F, Eisenmenger M, Latal D, Kargul G, et al. Phenotypic characterization of human skin mast cells by combined staining with toluidine blue and CD antibodies. J Invest Dermatol. 1998;111:689-95 pubmed
    ..Foreskin MC were also recognized by MoAb to CD47, CD48, CD49d, CD53, CD60, CD63, CD81, CD82, CD84, CD87, CD92, CD97, CD98, and CD99...
  48. Capasso M, Durrant L, Stacey M, Gordon S, Ramage J, Spendlove I. Costimulation via CD55 on human CD4+ T cells mediated by CD97. J Immunol. 2006;177:1070-7 pubmed
    ..CD55 also binds CD97, an EGF-TM7 receptor constitutively expressed on granulocytes and monocytes and rapidly up-regulated on T and B ..
  49. Eichler W. CD97 isoform expression in leukocytes. J Leukoc Biol. 2000;68:561-7 pubmed
    Different adhesive capacity in interactions with CD55 has been ascribed to the isoforms of the leukocyte CD97 antigen, CD97 (EGF 1,2,5), CD97 (EGF 1,2,3,5), and CD97 (EGF 1,2,3,4,5)...
  50. Liu D, Li C, Trojanowicz B, Li X, Shi D, Zhan C, et al. CD97 promotion of gastric carcinoma lymphatic metastasis is exosome dependent. Gastric Cancer. 2016;19:754-66 pubmed publisher
    b>CD97 knockdown impairs the metastatic capacity of SGC-7901 gastric cancer cells. However, the role of CD97 in the distant lymphatic premetastatic niche formation of gastric cancer remains unknown...
  51. Vogl U, Ohler L, Rasic M, Frischer J, Modak M, Stockl J. Evaluation of Prognostic Immune Signatures in Patients with Breast, Colorectal and Pancreatic Cancer Receiving Chemotherapy. Anticancer Res. 2017;37:1947-1955 pubmed
    b>CD97 is a member of the epidermal growth factor-seven transmembrane (EGF-TM7) receptor family and is dominantly expressed on immune cells and in a variety of malignant diseases...
  52. Abbott R, Spendlove I, Roversi P, Fitzgibbon H, Knott V, Teriete P, et al. Structural and functional characterization of a novel T cell receptor co-regulatory protein complex, CD97-CD55. J Biol Chem. 2007;282:22023-32 pubmed
    b>CD97, the archetypal member of the EGF-TM7 protein family, is constitutively expressed on granulocytes and monocytes and rapidly up-regulated on T and B cells following activation...
  53. Hsiao C, Wang W, Kuo W, Chen H, Chen T, Hamann J, et al. CD97 inhibits cell migration in human fibrosarcoma cells by modulating TIMP-2/MT1- MMP/MMP-2 activity--role of GPS autoproteolysis and functional cooperation between the N- and C-terminal fragments. FEBS J. 2014;281:4878-91 pubmed publisher
    b>CD97 is a tumor-associated adhesion-class G-protein-coupled receptor involved in modulating cell migration...
  54. Zyryanova T, Schneider R, Adams V, Sittig D, Kerner C, Gebhardt C, et al. Skeletal muscle expression of the adhesion-GPCR CD97: CD97 deletion induces an abnormal structure of the sarcoplasmatic reticulum but does not impair skeletal muscle function. PLoS ONE. 2014;9:e100513 pubmed publisher
    b>CD97 is a widely expressed adhesion class G-protein-coupled receptor (aGPCR)...
  55. Lu Y, Sweredoski M, Huss D, Lansford R, Hess S, Tirrell D. Prometastatic GPCR CD97 is a direct target of tumor suppressor microRNA-126. ACS Chem Biol. 2014;9:334-8 pubmed publisher
    ..We discovered a new direct target of miR-126: CD97, a pro-metastatic G-protein-coupled receptor (GPCR) that has been reported to promote tumor cell invasion, ..
  56. Park S, Lee K, Kang S, Chung H, Bae Y, Okajima F, et al. Lysophosphatidylethanolamine utilizes LPA(1) and CD97 in MDA-MB-231 breast cancer cells. Cell Signal. 2013;25:2147-54 pubmed publisher
    ..Furthermore, the involvement of CD97 (an adhesion GPCR) in the action of LPA1 in MDA-MB-231 cells was demonstrated by siRNA transfection...
  57. Kop E, Matmati M, Pouwels W, Leclercq G, Tak P, Hamann J. Differential expression of CD97 on human lymphocyte subsets and limited effect of CD97 antibodies on allogeneic T-cell stimulation. Immunol Lett. 2009;123:160-8 pubmed publisher
    b>CD97 is a large heptahelical EGF-TM7 receptor broadly expressed on hematopoietic cells as three isoforms with respectively three, four, or five epidermal growth factor (EGF)-like domains...
  58. Ward Y, Lake R, Martin P, Killian K, Salerno P, Wang T, et al. CD97 amplifies LPA receptor signaling and promotes thyroid cancer progression in a mouse model. Oncogene. 2013;32:2726-38 pubmed publisher
    b>CD97, a member of the adhesion family of G-protein-coupled receptors (GPCRs), complexes with and potentiates lysophosphatidic acid (LPA) receptor signaling to the downstream effector RHOA...