Gene Symbol: ADGRB1
Description: adhesion G protein-coupled receptor B1
Alias: BAI1, GDAIF, adhesion G protein-coupled receptor B1, brain-specific angiogenesis inhibitor 1
Species: human
Products:     ADGRB1

Top Publications

  1. Nishimori H, Shiratsuchi T, Urano T, Kimura Y, Kiyono K, Tatsumi K, et al. A novel brain-specific p53-target gene, BAI1, containing thrombospondin type 1 repeats inhibits experimental angiogenesis. Oncogene. 1997;15:2145-50 pubmed
    ..The expression of this gene, designated BAI1 (brain-specific angiogenesis inhibitor 1) was absent or significantly reduced in eight of nine glioblastoma cell ..
  2. Park D, Tosello Trampont A, Elliott M, Lu M, Haney L, Ma Z, et al. BAI1 is an engulfment receptor for apoptotic cells upstream of the ELMO/Dock180/Rac module. Nature. 2007;450:430-4 pubmed
    ..Here we identify brain-specific angiogenesis inhibitor 1 (BAI1) as a receptor upstream of ELMO and as a receptor that can bind phosphatidylserine on apoptotic cells...
  3. Fukushima Y, Oshika Y, Tsuchida T, Tokunaga T, Hatanaka H, Kijima H, et al. Brain-specific angiogenesis inhibitor 1 expression is inversely correlated with vascularity and distant metastasis of colorectal cancer. Int J Oncol. 1998;13:967-70 pubmed
    Brain-specific angiogenesis inhibitor (BAI) 1 was recently isolated as a novel p53 inducible gene. BAI1 has been suggested to play a significant role in angiostasis...
  4. Zhu D, Hunter S, Vertino P, Van Meir E. Overexpression of MBD2 in glioblastoma maintains epigenetic silencing and inhibits the antiangiogenic function of the tumor suppressor gene BAI1. Cancer Res. 2011;71:5859-70 pubmed publisher
    Brain angiogenesis inhibitor 1 (BAI1) is a putative G protein-coupled receptor with potent antiangiogenic and antitumorigenic properties that is mutated in certain cancers...
  5. Oda K, Shiratsuchi T, Nishimori H, Inazawa J, Yoshikawa H, Taketani Y, et al. Identification of BAIAP2 (BAI-associated protein 2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1. Cytogenet Cell Genet. 1999;84:75-82 pubmed
    b>BAI1 (brain-specific angiogenesis inhibitor 1) was originally isolated as a p53-target gene specifically expressed in brain...
  6. Kaur B, Brat D, Calkins C, Van Meir E. Brain angiogenesis inhibitor 1 is differentially expressed in normal brain and glioblastoma independently of p53 expression. Am J Pathol. 2003;162:19-27 pubmed
    ..b>BAI1 mRNA is expressed mainly in the brain, while BAI2 and BAI3 mRNAs are more widely expressed...
  7. Kaur B, Cork S, Sandberg E, Devi N, Zhang Z, Klenotic P, et al. Vasculostatin inhibits intracranial glioma growth and negatively regulates in vivo angiogenesis through a CD36-dependent mechanism. Cancer Res. 2009;69:1212-20 pubmed publisher
    ..Little is known about how this process is specifically regulated in the brain. Brain angiogenesis inhibitor-1 (BAI1) is a brain-predominant seven-transmembrane protein that contains five antiangiogenic thrombospondin type-1 repeats ..
  8. Kaur B, Brat D, Devi N, Van Meir E. Vasculostatin, a proteolytic fragment of brain angiogenesis inhibitor 1, is an antiangiogenic and antitumorigenic factor. Oncogene. 2005;24:3632-42 pubmed
    Brain angiogenesis inhibitor 1 (BAI1) is a transmembrane protein with unknown function expressed primarily in normal but not tumoral brain...
  9. Duda D, Sunamura M, Lozonschi L, Yokoyama T, Yatsuoka T, Motoi F, et al. Overexpression of the p53-inducible brain-specific angiogenesis inhibitor 1 suppresses efficiently tumour angiogenesis. Br J Cancer. 2002;86:490-6 pubmed
    ..Brain-specific angiogenesis inhibitor 1 should be considered for gene therapy and development of efficient drugs based on endogenous antiangiogenic molecules. ..

More Information


  1. Van Meir E, Polverini P, Chazin V, Su Huang H, de Tribolet N, Cavenee W. Release of an inhibitor of angiogenesis upon induction of wild type p53 expression in glioblastoma cells. Nat Genet. 1994;8:171-6 pubmed
  2. Shiratsuchi T, Oda K, Nishimori H, Suzuki M, Takahashi E, Tokino T, et al. Cloning and characterization of BAP3 (BAI-associated protein 3), a C2 domain-containing protein that interacts with BAI1. Biochem Biophys Res Commun. 1998;251:158-65 pubmed
    b>BAI1 (brain-specific angiogenesis inhibitor 1), a p53-target gene specifically expressed in brain, encodes a seven-span transmembrane protein considered to be a member of the secretin receptor family...
  3. Shiratsuchi T, Futamura M, Oda K, Nishimori H, Nakamura Y, Tokino T. Cloning and characterization of BAI-associated protein 1: a PDZ domain-containing protein that interacts with BAI1. Biochem Biophys Res Commun. 1998;247:597-604 pubmed
    Brain-specific angiogenesis inhibitor 1 (BAI1), which is a p53-target gene specifically expressed in brain, encodes a seven-span transmembrane protein...
  4. Shiratsuchi T, Nishimori H, Ichise H, Nakamura Y, Tokino T. Cloning and characterization of BAI2 and BAI3, novel genes homologous to brain-specific angiogenesis inhibitor 1 (BAI1). Cytogenet Cell Genet. 1997;79:103-8 pubmed
    We have identified two novel human genes homologous to BAI1 (brain-specific angiogenesis inhibitor 1), an angiogenesis inhibitor that is a candidate for involvement in development of glioblastoma...
  5. Mazaheri F, Breus O, Durdu S, Haas P, Wittbrodt J, Gilmour D, et al. Distinct roles for BAI1 and TIM-4 in the engulfment of dying neurons by microglia. Nat Commun. 2014;5:4046 pubmed publisher
    ..At the molecular level we found that microglia lacking the phosphatidylserine receptors BAI1 and TIM-4, are able to recognize the apoptotic targets but display distinct clearance defects...
  6. Moon S, Shin S, Oh Y, Park H, Lee C. Understanding the Role of the BAI Subfamily of Adhesion G Protein-Coupled Receptors (GPCRs) in Pathological and Physiological Conditions. Genes (Basel). 2018;9: pubmed publisher
    ..b>BAI1 is an engulfment receptor and performs major functions in apoptotic-cell clearance and interacts (as a pattern ..
  7. Sokolowski J, Nobles S, Heffron D, Park D, Ravichandran K, Mandell J. Brain-specific angiogenesis inhibitor-1 expression in astrocytes and neurons: implications for its dual function as an apoptotic engulfment receptor. Brain Behav Immun. 2011;25:915-21 pubmed publisher
    Brain-specific angiogenesis inhibitor-1 (BAI1) is a transmembrane protein highly expressed in normal brain that has been ascribed two apparently distinct functions: inhibition of angiogenesis and recognition and engulfment of apoptotic ..
  8. Lee C, Penberthy K, Wheeler K, Juncadella I, Vandenabeele P, Lysiak J, et al. Boosting Apoptotic Cell Clearance by Colonic Epithelial Cells Attenuates Inflammation In Vivo. Immunity. 2016;44:807-20 pubmed publisher
    ..In a colonic inflammation model, we noted that the expression of the phagocytic receptor Bai1 was progressively downmodulated...
  9. Weng Z, Situ C, Lin L, Wu Z, Zhu J, Zhang R. Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds. Nat Commun. 2019;10:51 pubmed publisher
    ..The crystal structures of ELMO2-RAE and its complex with BAI1 uncover the molecular basis of BAI/ELMO interactions...
  10. Hochreiter Hufford A, Lee C, Kinchen J, Sokolowski J, Arandjelovic S, Call J, et al. Phosphatidylserine receptor BAI1 and apoptotic cells as new promoters of myoblast fusion. Nature. 2013;497:263-7 pubmed publisher
    ..Here we report an unexpected discovery that the membrane protein BAI1, previously linked to recognition of apoptotic cells by phagocytes, promotes myoblast fusion...
  11. Zhu D, Li C, Swanson A, Villalba R, Guo J, Zhang Z, et al. BAI1 regulates spatial learning and synaptic plasticity in the hippocampus. J Clin Invest. 2015;125:1497-508 pubmed publisher
    ..Here, we demonstrated that mice lacking brain-specific angiogenesis inhibitor 1 (BAI1) have severe deficits in hippocampus-dependent spatial learning and memory that are accompanied by enhanced long-..
  12. Tu Y, Duman J, Tolias K. The Adhesion-GPCR BAI1 Promotes Excitatory Synaptogenesis by Coordinating Bidirectional Trans-synaptic Signaling. J Neurosci. 2018;38:8388-8406 pubmed publisher
    ..The postsynaptic adhesion-G protein-coupled receptor (A-GPCR) BAI1 is a critical regulator of excitatory synaptogenesis, which functions in part by recruiting the Par3-Tiam1 polarity ..
  13. Gęgotek A, Domingues P, Wroński A, Wojcik P, Skrzydlewska E. Proteomic plasma profile of psoriatic patients. J Pharm Biomed Anal. 2018;155:185-193 pubmed publisher
    ..associated with increased expression of proteins directly involved in signaling molecule secretion [biotinidase and BAI1-associated protein 3]...
  14. Nakanishi Y, Akiyama N, Tsukaguchi T, Fujii T, Satoh Y, Ishii N, et al. Mechanism of Oncogenic Signal Activation by the Novel Fusion Kinase FGFR3-BAIAP2L1. Mol Cancer Ther. 2015;14:704-12 pubmed publisher
    ..We investigated a recently discovered gene fusion between FGFR3 and BAI1-associated protein 2-like 1 (BAIAP2L1)...
  15. Zhu D, Osuka S, Zhang Z, Reichert Z, Yang L, Kanemura Y, et al. BAI1 Suppresses Medulloblastoma Formation by Protecting p53 from Mdm2-Mediated Degradation. Cancer Cell. 2018;33:1004-1016.e5 pubmed publisher
    ..We show the ADGRB1 gene, which encodes Brain-specific angiogenesis inhibitor 1 (BAI1), is epigenetically silenced in medulloblastomas ..
  16. Bagci H, Laurin M, Huber J, Muller W, Côté J. Impaired cell death and mammary gland involution in the absence of Dock1 and Rac1 signaling. Cell Death Dis. 2014;5:e1375 pubmed publisher
    ..In mammals, Elmo1 was shown to interact with the phosphatidylserine receptor Bai1 and relay signals to promote phagocytosis of apoptotic cells...
  17. Hamann J, Hsiao C, Lee C, Ravichandran K, Lin H. Adhesion GPCRs as Modulators of Immune Cell Function. Handb Exp Pharmacol. 2016;234:329-350 pubmed
    ..ADGRE1), EMR2 (ADGRE2), EMR3 (ADGRE3), EMR4 (FIRE, ADGRE4), and CD97 (ADGRE5), the ADGRB subfamily member BAI1 (ADGRB1), and the ADGRG subfamily members GPR56 (ADGRG1), GPR97 (Pb99, ADGRG3), and GPR114 (ADGRG5)...
  18. Choi Y, Lee S, Kim M, Jung S, Hur S, Chung Y, et al. Whole-exome sequencing identified the genetic origin of a mucinous neoplasm in a mature cystic teratoma. Pathology. 2016;48:372-6 pubmed publisher
    ..that included eight putative driver gene mutations catalogued in COSMIC database (KRAS, GNAS, ZBTB38, ENAM, HTR5A, BAI1, ADAMTS8 and RASA3)...
  19. Das S, Owen K, Ly K, Park D, Black S, Wilson J, et al. Brain angiogenesis inhibitor 1 (BAI1) is a pattern recognition receptor that mediates macrophage binding and engulfment of Gram-negative bacteria. Proc Natl Acad Sci U S A. 2011;108:2136-41 pubmed publisher
    ..Brain angiogenesis inhibitor 1 (BAI1) is a receptor that recognizes apoptotic cells through its conserved type I thrombospondin repeats and triggers ..
  20. Mathema V, Na Bangchang K. Regulatory roles of brain-specific angiogenesis inhibitor 1(BAI1) protein in inflammation, tumorigenesis and phagocytosis: A brief review. Crit Rev Oncol Hematol. 2017;111:81-86 pubmed publisher
    ..Here we mainly focus on the regulatory activities of a prominent member of BAI family, BAI1, with respect to its role in inflammation, tumorigenesis and phagocytosis...
  21. Fan W, Chang S, Shan X, Gao D, Zhang S, Zhang J, et al. Transcriptional profile of SH-SY5Y human neuroblastoma cells transfected by Toxoplasma rhoptry protein 16. Mol Med Rep. 2016;14:4099-4108 pubmed publisher
    ..Several genes, including CXCL12, BAI1, ZIC2, RBMX, RASSF6, MAGE?A6 and HOX, were identified as significant DEGs...
  22. Fond A, Lee C, Schulman I, Kiss R, Ravichandran K. Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1. J Clin Invest. 2015;125:2748-58 pubmed publisher
    ..This pathway involves the phagocytic receptor brain-specific angiogenesis inhibitor 1 (BAI1), which recognizes phosphatidylserine on apoptotic cells, and the intracellular signaling intermediates engulfment ..
  23. Chao A, Tsai C, Jung S, Chuang W, Kao C, Hsu A, et al. BAI1-Associated Protein 2-Like 1 (BAIAP2L1) Is a Potential Biomarker in Ovarian Cancer. PLoS ONE. 2015;10:e0133081 pubmed publisher
    Brain-specific angiogenesis inhibitor 1 (BAI1)-associated protein 2-like 1 (BAIAP2L1), also known as insulin receptor tyrosine kinase substrate (IRTKS), is involved in plasma membrane protrusion and actin formation during cell ..
  24. Billings E, Lee C, Owen K, D Souza R, Ravichandran K, Casanova J. The adhesion GPCR BAI1 mediates macrophage ROS production and microbicidal activity against Gram-negative bacteria. Sci Signal. 2016;9:ra14 pubmed publisher
    ..We previously characterized brain-specific angiogenesis inhibitor 1 (BAI1), a member of the adhesion family of G protein (heterotrimeric guanine nucleotide-binding protein)-coupled ..
  25. Penberthy K, Rival C, Shankman L, Raymond M, Zhang J, Perry J, et al. Context-dependent compensation among phosphatidylserine-recognition receptors. Sci Rep. 2017;7:14623 pubmed publisher
    ..Here, we overexpressed the PtdSer receptor BAI1 in mice lacking MerTK (Mertk -/- Bai1 Tg ) to evaluate PtdSer receptor compensation in vivo...
  26. Tian D, Hu H, Sun Y, Tang Y, Lei M, Liu L, et al. Expression of brain?specific angiogenesis inhibitor?1 and association with p53, microvessel density and vascular endothelial growth factor in the tissue of human bladder transitional cell carcinoma. Mol Med Rep. 2015;12:4522-4529 pubmed publisher
    ..001), mutant p53 (r=?0.406, P=0.002) and with the MVD (r=?0.675, P<0.001). BAI?1 may be involved in the negative regulation of BTCC microvascular proliferation, and its expression may be associated with a reduction in p53 mutations. ..
  27. Das S, Sarkar A, Ryan K, Fox S, Berger A, Juncadella I, et al. Brain angiogenesis inhibitor 1 is expressed by gastric phagocytes during infection with Helicobacter pylori and mediates the recognition and engulfment of human apoptotic gastric epithelial cells. FASEB J. 2014;28:2214-24 pubmed publisher
    ..In this study, we assessed the expression and function of brain angiogenesis inhibitor 1 (BAI1) in the engulfment of apoptotic GECs using human tissue and cells. After induction of apoptosis by H...
  28. Cork S, Kaur B, Devi N, Cooper L, Saltz J, Sandberg E, et al. A proprotein convertase/MMP-14 proteolytic cascade releases a novel 40?kDa vasculostatin from tumor suppressor BAI1. Oncogene. 2012;31:5144-52 pubmed publisher
    Brain-specific angiogenesis inhibitor 1 (BAI1), an orphan G protein-coupled receptor-type seven transmembrane protein, was recently found mutated or silenced in multiple human cancers and can interfere with tumor growth when overexpressed...
  29. Adkins J, Varnum S, Auberry K, Moore R, Angell N, Smith R, et al. Toward a human blood serum proteome: analysis by multidimensional separation coupled with mass spectrometry. Mol Cell Proteomics. 2002;1:947-55 pubmed
    ..With this study, we have performed the most extensive analysis of serum proteins to date and laid the foundation for future refinements in the identification of novel protein biomarkers of disease. ..
  30. Koh J, Kook H, Kee H, Seo Y, Jeong B, Lee J, et al. Extracellular fragment of brain-specific angiogenesis inhibitor 1 suppresses endothelial cell proliferation by blocking alphavbeta5 integrin. Exp Cell Res. 2004;294:172-84 pubmed
    Brain-specific angiogenesis inhibitor 1 (BAI1) is a transmembrane protein with anti-angiogenic activity. The mechanisms underlying BAI1 activity are unknown...
  31. Kishore A, Purcell R, Nassiri Toosi Z, Hall R. Stalk-dependent and Stalk-independent Signaling by the Adhesion G Protein-coupled Receptors GPR56 (ADGRG1) and BAI1 (ADGRB1). J Biol Chem. 2016;291:3385-94 pubmed publisher
    ..Several aGPCRs, including ADGRB1 (BAI1 or B1) and ADGRG1 (GPR56 or G1), have been found to exhibit significantly increased constitutive activity ..
  32. Meisen W, Dubin S, Sizemore S, Mathsyaraja H, Thies K, Lehman N, et al. Changes in BAI1 and nestin expression are prognostic indicators for survival and metastases in breast cancer and provide opportunities for dual targeted therapies. Mol Cancer Ther. 2015;14:307-14 pubmed publisher
    ..Brain angiogenesis inhibitor 1 (BAI1) is a GPCR involved in tumor angiogenesis, invasion, phagocytosis, and synaptogenesis...
  33. Lim I, Hall D, Hell J. Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102. J Biol Chem. 2002;277:21697-711 pubmed
    ..Two of these proteins, brain-specific angiogenesis inhibitor 1 and protein kinase Calpha, co-immunoprecipitated with PSD-95 and SAP102 from rat brain extracts. ..
  34. Mori K, Kanemura Y, Fujikawa H, Nakano A, Ikemoto H, Ozaki I, et al. Brain-specific angiogenesis inhibitor 1 (BAI1) is expressed in human cerebral neuronal cells. Neurosci Res. 2002;43:69-74 pubmed
    Brain-specific angiogenesis inhibitor 1 (BAI1) is a p53-target gene specifically expressed in the brain...
  35. Stephenson J, Paavola K, Schaefer S, Kaur B, Van Meir E, Hall R. Brain-specific angiogenesis inhibitor-1 signaling, regulation, and enrichment in the postsynaptic density. J Biol Chem. 2013;288:22248-56 pubmed publisher
    Brain-specific angiogenesis inhibitor-1 (BAI1) is an adhesion G protein-coupled receptor that has been studied primarily for its anti-angiogenic and anti-tumorigenic properties...
  36. Bolyard C, Meisen W, Banasavadi Siddegowda Y, Hardcastle J, Yoo J, Wohleb E, et al. BAI1 Orchestrates Macrophage Inflammatory Response to HSV Infection-Implications for Oncolytic Viral Therapy. Clin Cancer Res. 2017;23:1809-1819 pubmed publisher
    b>Purpose: Brain angiogenesis inhibitor (BAI1) facilitates phagocytosis and bacterial pathogen clearance by macrophages; however, its role in viral infections is unknown...
  37. Duman J, Tzeng C, Tu Y, Munjal T, Schwechter B, Ho T, et al. The adhesion-GPCR BAI1 regulates synaptogenesis by controlling the recruitment of the Par3/Tiam1 polarity complex to synaptic sites. J Neurosci. 2013;33:6964-78 pubmed publisher
    ..Here, we identify brain-specific angiogenesis inhibitor 1 (BAI1) as a synaptic adhesion GPCR that is required for spinogenesis and synaptogenesis in mice and rats...
  38. Marker D, Puccini J, Mockus T, Barbieri J, Lu S, Gelbard H. LRRK2 kinase inhibition prevents pathological microglial phagocytosis in response to HIV-1 Tat protein. J Neuroinflammation. 2012;9:261 pubmed publisher
    ..In addition, LRRK2i decreased brain-specific angiogenesis inhibitor 1 (BAI1) receptor expression on BV-2 cells after Tat-treatment, a key receptor in phosphatidylserine-mediated phagocytosis. ..
  39. Patel M, Chiang T, Tran V, Lee F, Cote J. The Arf family GTPase Arl4A complexes with ELMO proteins to promote actin cytoskeleton remodeling and reveals a versatile Ras-binding domain in the ELMO proteins family. J Biol Chem. 2011;286:38969-79 pubmed publisher
    ..Furthermore, via binding of an Arf family GTPase, the ELMO-DOCK180 is uniquely positioned at the membrane to activate Rac signaling and remodel the actin cytoskeleton. ..
  40. Koh J, Lee Z, Ahn K, Kim J, Bae C, Kim H, et al. Characterization of mouse brain-specific angiogenesis inhibitor 1 (BAI1) and phytanoyl-CoA alpha-hydroxylase-associated protein 1, a novel BAI1-binding protein. Brain Res Mol Brain Res. 2001;87:223-37 pubmed
    ..The ability of BAP4 to interact with BAI1 was confirmed by pulling-down BAI1 with GST-BAP4 protein and immunoprecipitation study using brain lysate...
  41. Wu Y, Dowbenko D, Spencer S, Laura R, Lee J, Gu Q, et al. Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase. J Biol Chem. 2000;275:21477-85 pubmed
    ..Importantly, MAGI3 and PTEN/MMAC cooperate to modulate the kinase activity of AKT/PKB. These data suggest that MAGI3 allows for the juxtaposition of PTEN/MMAC to phospholipid signaling pathways involved with cell survival. ..