adenosine deaminase

Summary

Gene Symbol: adenosine deaminase
Description: adenosine deaminase
Alias: adenosine deaminase, adenosine aminohydrolase
Species: human
Products:     adenosine deaminase

Top Publications

  1. Gonzalez Gronow M, Hershfield M, Arredondo Vega F, Pizzo S. Cell surface adenosine deaminase binds and stimulates plasminogen activation on 1-LN human prostate cancer cells. J Biol Chem. 2004;279:20993-8 pubmed
    b>Adenosine deaminase (ADA) is expressed intracellularly by all cells, but in some tissues, it is also associated with the cell surface multifunctional glycoprotein CD26/dipeptidyl peptidase IV...
  2. Bottini N, Gloria Bottini F, Borgiani P, Antonacci E, Lucarelli P, Bottini E. Type 2 diabetes and the genetics of signal transduction: a study of interaction between adenosine deaminase and acid phosphatase locus 1 polymorphisms. Metabolism. 2004;53:995-1001 pubmed
    ..b>Adenosine deaminase (ADA) is a polymorphic enzyme that catalyses the irreversible deamination of adenosine to inosine and has ..
  3. Taysi S, Polat M, Sari R, Bakan E. Serum adenosine deaminase and cytidine deaminase activities in patients with systemic lupus erythematosus. Clin Chem Lab Med. 2002;40:493-5 pubmed
    We evaluated serum total adenosine deaminase, its isoenzymes adenosine deaminase-1 and adenosine deaminase-2, and cytidine deaminase activities in 24 patients with active systemic lupus erythematosus, and in 26 healthy control subjects, ..
  4. Richard E, Alam S, Arredondo Vega F, Patel D, Hershfield M. Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV. J Biol Chem. 2002;277:19720-6 pubmed
    Human adenosine deaminase (ADA) occurs as a 41-kDa soluble monomer in all cells. On epithelia and lymphoid cells of humans, but not mice, ADA also occurs bound to the membrane glycoprotein CD26/dipeptidyl peptidase IV...
  5. Herrera C, Casado V, Ciruela F, Schofield P, Mallol J, Lluis C, et al. Adenosine A2B receptors behave as an alternative anchoring protein for cell surface adenosine deaminase in lymphocytes and cultured cells. Mol Pharmacol. 2001;59:127-34 pubmed
    b>Adenosine deaminase (ADA) is an enzyme of the purine metabolism that has been largely considered to be cytosolic...
  6. Cassani B, Mirolo M, Cattaneo F, Benninghoff U, Hershfield M, Carlucci F, et al. Altered intracellular and extracellular signaling leads to impaired T-cell functions in ADA-SCID patients. Blood. 2008;111:4209-19 pubmed publisher
    Mutations in the adenosine deaminase (ADA) gene are responsible for a form of severe combined immunodeficiency (SCID) caused by the lymphotoxic accumulation of ADA substrates, adenosine and 2'-deoxy-adenosine...
  7. Zavialov A, Gracia E, Glaichenhaus N, Franco R, Zavialov A, Lauvau G. Human adenosine deaminase 2 induces differentiation of monocytes into macrophages and stimulates proliferation of T helper cells and macrophages. J Leukoc Biol. 2010;88:279-90 pubmed publisher
    ..Our discovery of the growth factor-like activity of ADA2 explains clinical observations and suggests that this enzyme could be used as a drug candidate to modulate the immune responses during inflammation and cancer. ..
  8. Napolioni V, Predazzi I. Age- and gender-specific association between ADA (22G>A) and TNF-? (-308G>A) genetic polymorphisms. Tissue Antigens. 2010;76:311-4 pubmed publisher
    ..In the present study, we evaluated the genetic relationship between the functional adenosine deaminase (ADA) (22G>A, rs73598374) and TNF-? (-308G>A, rs1800629) SNPs in a healthy population from central ..
  9. Rétey J, Adam M, Honegger E, Khatami R, Luhmann U, Jung H, et al. A functional genetic variation of adenosine deaminase affects the duration and intensity of deep sleep in humans. Proc Natl Acad Sci U S A. 2005;102:15676-81 pubmed
    ..Here we show in humans that a genetic variant of adenosine deaminase, which is associated with the reduced metabolism of adenosine to inosine, specifically enhances deep sleep ..

More Information

Publications105 found, 100 shown here

  1. Mazzotti D, Guindalini C, Pellegrino R, Barrueco K, Santos Silva R, Bittencourt L, et al. Effects of the adenosine deaminase polymorphism and caffeine intake on sleep parameters in a large population sample. Sleep. 2011;34:399-402 pubmed
    To evaluate the association between the adenosine deaminase polymorphism, sleep architecture, and caffeine consumption. Genetic association study. NA. 958 participants who underwent polysomnography and genotyping. NA...
  2. Fan H, Tansi F, Weihofen W, Bottcher C, Hu J, Martinez J, et al. Molecular mechanism and structural basis of interactions of dipeptidyl peptidase IV with adenosine deaminase and human immunodeficiency virus type-1 transcription transactivator. Eur J Cell Biol. 2012;91:265-73 pubmed publisher
    ..In this paper, we review our recent studies on the interactions of DPPIV with adenosine deaminase (ADA) and the transcription transactivator of the human immunodeficiency virus type-1 (HIV-1 Tat) as ..
  3. Napolioni V, Carpi F, Giannì P, Sacco R, Di Blasio L, Mignini F, et al. Age- and gender-specific epistasis between ADA and TNF-? influences human life-expectancy. Cytokine. 2011;56:481-8 pubmed publisher
    ..we examined the main effects of single loci and multi-locus interactions to test the hypothesis that the adenosine deaminase (ADA) and tumor necrosis factor alpha (TNF-?) genes may influence human life-expectancy...
  4. Mazzotti D, Guindalini C, de Souza A, Sato J, Santos Silva R, Bittencourt L, et al. Adenosine deaminase polymorphism affects sleep EEG spectral power in a large epidemiological sample. PLoS ONE. 2012;7:e44154 pubmed publisher
    ..Adenosine is strongly implicated in sleep homeostasis, and a single nucleotide polymorphism in the adenosine deaminase gene (ADA G22A) has been associated with deeper and more efficient sleep...
  5. Martin M, Huguet J, Centelles J, Franco R. Expression of ecto-adenosine deaminase and CD26 in human T cells triggered by the TCR-CD3 complex. Possible role of adenosine deaminase as costimulatory molecule. J Immunol. 1995;155:4630-43 pubmed
    The expression of surface adenosine deaminase (ADA) and CD26 in activated human T cells was studied by flow cytometry...
  6. Hirschhorn R, Yang D, Israni A. An Asp8Asn substitution results in the adenosine deaminase (ADA) genetic polymorphism (ADA 2 allozyme): occurrence on different chromosomal backgrounds and apparent intragenic crossover. Ann Hum Genet. 1994;58:1-9 pubmed
    We have now determined the molecular genetic basis for the common biochemical polymorphism at the adenosine deaminase (ADA) locus...
  7. Pacheco R, Martinez Navio J, Lejeune M, Climent N, Oliva H, Gatell J, et al. CD26, adenosine deaminase, and adenosine receptors mediate costimulatory signals in the immunological synapse. Proc Natl Acad Sci U S A. 2005;102:9583-8 pubmed
    b>Adenosine deaminase (ADA), a protein whose deficit leads to severe combined immunodeficiency, binds to the cell surface by means of either CD26, A(1) adenosine receptors, or A(2B) adenosine receptors...
  8. Parish S, Kim S, Sekhon R, Wu J, Kawakatsu Y, Effros R. Adenosine deaminase modulation of telomerase activity and replicative senescence in human CD8 T lymphocytes. J Immunol. 2010;184:2847-54 pubmed publisher
    ..The present study investigates the role of a second T cell costimulatory receptor component, adenosine deaminase (ADA), on the process of replicative senescence...
  9. Kameoka J, Tanaka T, Nojima Y, Schlossman S, Morimoto C. Direct association of adenosine deaminase with a T cell activation antigen, CD26. Science. 1993;261:466-9 pubmed
    ..acid sequence analysis and immunoprecipitation studies demonstrated that this 43-kilodalton protein was adenosine deaminase (ADA)...
  10. Eltzschig H, Faigle M, Knapp S, Karhausen J, Ibla J, Rosenberger P, et al. Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. Blood. 2006;108:1602-10 pubmed
    ..Guided by microarray results revealing induction of endothelial adenosine deaminase (ADA) mRNA in hypoxia, we used in vitro and in vivo models of adenosine signaling, confirming induction of ..
  11. Safranow K, Rzeuski R, Binczak Kuleta A, Czyzycka E, Skowronek J, Jakubowska K, et al. ADA*2 allele of the adenosine deaminase gene may protect against coronary artery disease. Cardiology. 2007;108:275-81 pubmed
    The common G22A polymorphism in the adenosine deaminase (ADA) gene leads to substitution Asp8Asn...
  12. Gass N, Ollila H, Utge S, Partonen T, Kronholm E, Pirkola S, et al. Contribution of adenosine related genes to the risk of depression with disturbed sleep. J Affect Disord. 2010;126:134-9 pubmed publisher
    ..The shortage of overlapping genes between the genders indicates that the genetics of mood regulation may vary between the sexes. ..
  13. Dutra G, Ottoni G, Lara D, Bogo M. Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients. Braz J Psychiatry. 2010;32:275-8 pubmed
    ..b>Adenosine deaminase participates in purine metabolism by converting adenosine into inosine...
  14. Blanco J, Valenzuela A, Herrera C, Lluis C, Hovanessian A, Franco R. The HIV-1 gp120 inhibits the binding of adenosine deaminase to CD26 by a mechanism modulated by CD4 and CXCR4 expression. FEBS Lett. 2000;477:123-8 pubmed
    HIV-1 external envelope glycoprotein gp120 inhibits adenosine deaminase (ADA) binding to its cell surface receptor in lymphocytes, CD26, by a mechanism that does not require the gp120-CD4 interaction...
  15. Climent N, Martinez Navio J, Gil C, Garcia F, Rovira C, Hurtado C, et al. Adenosine deaminase enhances T-cell response elicited by dendritic cells loaded with inactivated HIV. Immunol Cell Biol. 2009;87:634-9 pubmed publisher
    ..Owing to the fact that adenosine deaminase (ADA) is a member of the family of growth factor with deaminase activity, we tested whether it could ..
  16. Napolioni V, Lucarini N. Gender-specific association of ADA genetic polymorphism with human longevity. Biogerontology. 2010;11:457-62 pubmed publisher
    Aim of this study was to investigate whether the polymorphic ADA (Adenosine Deaminase, EC 3.5.4...
  17. Martinez Navio J, Casanova V, Pacheco R, Naval Macabuhay I, Climent N, Garcia F, et al. Adenosine deaminase potentiates the generation of effector, memory, and regulatory CD4+ T cells. J Leukoc Biol. 2011;89:127-36 pubmed publisher
    ..These data suggest that ADA is a relevant modulator of CD4+ T cell differentiation, even in cells from immunologically compromised individuals. ..
  18. Riksen N, Franke B, van den Broek P, Naber M, Smits P, Rongen G. The 22G>A polymorphism in the adenosine deaminase gene impairs catalytic function but does not affect reactive hyperaemia in humans in vivo. Pharmacogenet Genomics. 2008;18:843-6 pubmed publisher
    ..b>Adenosine deaminase (ADA) is an enzyme that catalyzes the irreversible deamination of adenosine...
  19. Bachmann V, Klaus F, Bodenmann S, Schäfer N, Brugger P, Huber S, et al. Functional ADA polymorphism increases sleep depth and reduces vigilant attention in humans. Cereb Cortex. 2012;22:962-70 pubmed publisher
    ..The nonsynonymous c.22G>A polymorphism (rs73598374) of adenosine deaminase (ADA) reduces the conversion of adenosine to inosine and predicts baseline differences in sleep slow-wave ..
  20. Reichert C, Maire M, Gabel V, Viola A, Kolodyazhniy V, Strobel W, et al. Insights into behavioral vulnerability to differential sleep pressure and circadian phase from a functional ADA polymorphism. J Biol Rhythms. 2014;29:119-30 pubmed publisher
    ..40 h multiple naps), we investigated the influence of a human adenosine deaminase (ADA) polymorphism (rs73598374) on several behavioral measures throughout nearly 2 circadian cycles...
  21. Zhang H, Lu J, Feng R. [Correlations of 24 biochemical markers in seminal plasma with routine semen parameters]. Zhonghua Nan Ke Xue. 2015;21:1087-92 pubmed
    ..GGT), lactate dehydrogenase (LDH), creatine kinase (CK), alpha hydroxybutyrate dehydrogenase (αHBDH), adenosine deaminase (ADA), glucose (Glu), triglyeride (TG), total cholesterol (TC), urea nitrogen (UN), creatinine (Cr), high-..
  22. Seo J, Osorio J, Schmitt E, Corrêa M, Bertoni G, Trevisi E, et al. Hepatic purinergic signaling gene network expression and its relationship with inflammation and oxidative stress biomarkers in blood from peripartal dairy cattle. J Dairy Sci. 2014;97:861-73 pubmed publisher
    ..diphosphohydrolase 7 (ENTPD7), ectonucleotide pyrophosphatase/phosphodiesterase 2 (ENPP2), ENPP3, and adenosine deaminase (ADA)], and a type 2 purinergic receptor (P2RX7) was downregulated after calving...
  23. Chinen J, Cowan M. Advances and highlights in primary immunodeficiencies in 2017. J Allergy Clin Immunol. 2018;142:1041-1051 pubmed publisher
    ..screening; (7) demonstration of the efficacy of lentiviral vector-mediated gene therapy for patients with adenosine deaminase-deficient SCID; (8) the promise of gene editing for PIDDs using CRISPR/Cas9 and zinc finger nuclease ..
  24. de Souza R, Bretanha L, Dalmarco E, Pizzolatti M, Fröde T. Modulatory effect of Senecio brasiliensis (Spreng) Less. in a murine model of inflammation induced by carrageenan into the pleural cavity. J Ethnopharmacol. 2015;168:373-9 pubmed publisher
    ..This effect may be attributed to the inhibition of pro-inflammatory cytokines and the reduction of the NF-κB pathway. The compounds Sen, Int, and DCQs may be responsible for the anti-inflammatory actions of S. brasiliensis. ..
  25. Modica M, Lombardo F, Franchini P, Oliverio M. The venomous cocktail of the vampire snail Colubraria reticulata (Mollusca, Gastropoda). BMC Genomics. 2015;16:441 pubmed publisher
    ..proteins and turripeptides (ion-channel blockers), Cysteine-rich secretory proteins (CRISPs), Adenosine Deaminase (ADA); 2) inhibitors of primary haemostasis, such as novel vWFA domain-containing proteins, the ..
  26. Usman T, Areola E, Badmus O, Kim I, Olatunji L. Sodium acetate and androgen receptor blockade improve gestational androgen excess-induced deteriorated glucose homeostasis and antioxidant defenses in rats: roles of adenosine deaminase and xanthine oxidase activities. J Nutr Biochem. 2018;62:65-75 pubmed publisher
    ..gestational androgen excess prevents glucose dysmetabolism and poor fetal outcome through suppression of adenosine deaminase (ADA)/xanthine oxidase (XO) pathway...
  27. Zhang J, Zhang F, Guo L, Li N, Shan B. Chronic alcohol administration affects purine nucleotide catabolism in vivo. Life Sci. 2017;168:58-64 pubmed publisher
    ..Enzymatic activities of adenosine deaminase (ADA), xanthine oxidase (XO), ribose 5-phosphate pyrophosphokinase (RPPPK), glutamine ..
  28. Sartori G, Jardim N, Sari M, Flores E, Prigol M, Nogueira C. Diphenyl Diselenide Reduces Oxidative Stress and Toxicity Caused by HSV-2 Infection in Mice. J Cell Biochem. 2017;118:1028-1037 pubmed publisher
    ..The activities of adenosine deaminase (ADA), Na+ /K+ -ATPase (liver and kidney); alanine aminotransferase (ALT), aspartate ..
  29. Hettinger J, Liu X, Holden J. The G22A polymorphism of the ADA gene and susceptibility to autism spectrum disorders. J Autism Dev Disord. 2008;38:14-9 pubmed
    ..This hypothesis is supported by the finding of decreased adenosine deaminase (ADA) activity in the sera of some children with autism and reports of an association of the A allele of ..
  30. Gloria Bottini F, Pietropolli A, Coppeta L, Magrini A, Bergamaschi A, Bottini E. The genetics of feto-placental development: a study of acid phosphatase locus 1 and adenosine deaminase polymorphisms in a consecutive series of newborn infants. Reprod Biol Endocrinol. 2008;6:38 pubmed publisher
    Acid phosphatase locus 1 and adenosine deaminase locus 1 polymorphisms show cooperative effects on glucose metabolism and immunological functions...
  31. Setarehbadi R, Hosseinipanah S, Vatannejad A, Karimi M, Vaisi raygani A, Tavilani H. Adenosine deaminase activity during menses, follicular and luteal phases of the menstrual cycle. Eur J Obstet Gynecol Reprod Biol. 2011;155:233-4 pubmed publisher
  32. Jornayvaz F. [News in diabetology 2015]. Rev Med Suisse. 2016;12:30-1 pubmed
    ..A new insulin pump than can be coupled with a glucosensor was released. Finally, a new unexpected complication of SGLT2 inhibitors treatment was reported, the euglycemic keto-acidosis. ..
  33. Ramos Morales F, Dominguez A, Rios R, Barroso S, Infante C, Schweighoffer F, et al. Adenosine deaminase is a specific partner for the Grb2 isoform Grb3-3. Biochem Biophys Res Commun. 1997;237:735-40 pubmed
    ..We have identified adenosine deaminase, an enzyme involved in purine metabolism whose deficiency is associated with severe combined ..
  34. Pangilinan F, Molloy A, Mills J, Troendle J, Parle McDermott A, Kay D, et al. Replication and exploratory analysis of 24 candidate risk polymorphisms for neural tube defects. BMC Med Genet. 2014;15:102 pubmed publisher
    ..We therefore believe the true effect of these four nominally significant SNPs on NTD risk will be more definitively determined by further study in other populations, and eventual meta-analysis. ..
  35. Otsuguro K, Tomonari Y, Otsuka S, Yamaguchi S, Kon Y, Ito S. An adenosine kinase inhibitor, ABT-702, inhibits spinal nociceptive transmission by adenosine release via equilibrative nucleoside transporters in rat. Neuropharmacology. 2015;97:160-70 pubmed publisher
    ..an adenosine A1 receptor antagonist, and augmented by EHNA (erythro-9-(2-hydroxy-3-nonyl) adenine), an adenosine deaminase (ADA) inhibitor...
  36. Glessner M. American Diabetes Association - 75th Scientific Sessions (June 5-9, 2015 - Boston, Massachusetts, USA). Drugs Today (Barc). 2015;51:383-6 pubmed publisher
    ..A significant number of presentations considered experimental and investigational therapeutic candidates that will potentially aid in the fight against diabetes, which continues to be on the increase worldwide. ..
  37. Santos Gómez M, Calvo Río V, Blanco R, Beltran E, Mesquida M, Adan A, et al. The effect of biologic therapy different from infliximab or adalimumab in patients with refractory uveitis due to Behçet's disease: results of a multicentre open-label study. Clin Exp Rheumatol. 2016;34:S34-S40 pubmed
    ..Six patients achieved a complete remission of uveitis. The vast majority of patients with BU refractory to standard immunosuppressive drugs are successfully controlled with ADA and/or IFX. Other biologic agents appear to be also useful. ..
  38. Lee J, Yoo S, Lee S, Cha S, Park J, Kim C. Pleural fluid adenosine deaminase/serum C-reactive protein ratio for the differentiation of tuberculous and parapneumonic effusions with neutrophilic predominance and high adenosine deaminase levels. Infection. 2017;45:59-65 pubmed publisher
    ..TPE) and parapneumonic effusion (PPE) are usually distinguished by cellular predominance and pleural fluid adenosine deaminase (ADA) levels...
  39. Solari L, Soto A, Van der Stuyft P. Performance of clinical prediction rules for diagnosis of pleural tuberculosis in a high-incidence setting. Trop Med Int Health. 2017;22:1283-1292 pubmed publisher
    ..6 and a negative LR of 0.2. Many CPRs for PT are available. In addition to ADA alone, none of them contributes significantly to diagnosis of PT. ..
  40. Al Saiqali M, Tangutur A, Banoth C, Bhukya B. Antimicrobial and anticancer potential of low molecular weight polypeptides extracted and characterized from leaves of Azadirachta indica. Int J Biol Macromol. 2018;114:906-921 pubmed publisher
    ..96, 59.61±0.75 for 24h and 48h, respectively. The results of present study indicate that these polypeptides exhibit broad spectrum antimicrobial and anticancer activity and can therefore be explored for their therapeutic potential. ..
  41. Sebastiao A, Macedo M, Ribeiro J. Tonic activation of A(2A) adenosine receptors unmasks, and of A(1) receptors prevents, a facilitatory action of calcitonin gene-related peptide in the rat hippocampus. Br J Pharmacol. 2000;129:374-80 pubmed
    ..3. The A(2A) receptor antagonist, ZM 241385 (10 nM) as well as adenosine deaminase (ADA, 2 U ml(-1)), prevented the enhancement of field EPSP slope caused by CGRP (30 nM) in the presence of ..
  42. Baldissera M, Souza C, Baldisserotto B. Purinergic signaling modulates the splenic inflammatory response in silver catfish naturally infected with Ichthyophthirius multifiliis. Parasitol Res. 2018;117:1169-1173 pubmed publisher
    ..are regulated by the enzymes nucleoside triphosphate diphosphohydrolase (NTPDase), 5'-nucleotidase, and adenosine deaminase (ADA)...
  43. Kagan V, Mao G, Qu F, Angeli J, Doll S, Croix C, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 2017;13:81-90 pubmed publisher
    ..This oxidative PE death pathway may also represent a target for drug discovery. ..
  44. Herskovitz J, Ryman J, Thway T, Lee S, Zhou L, Chirmule N, et al. Immune Suppression During Preclinical Drug Development Mitigates Immunogenicity-Mediated Impact on Therapeutic Exposure. AAPS J. 2017;19:447-455 pubmed publisher
    ..Such preconditioning can support preclinical drug development of human therapeutics that are antigenic to animals. Similar approaches could be investigated for wider application to novel therapeutics. ..
  45. De Cicco P, Panza E, Armogida C, Ercolano G, Taglialatela Scafati O, Shokoohinia Y, et al. The Hydrogen Sulfide Releasing Molecule Acetyl Deacylasadisulfide Inhibits Metastatic Melanoma. Front Pharmacol. 2017;8:65 pubmed publisher
    ..In conclusion, our findings suggest that ADA significantly inhibits melanoma progression in vivo and could represent an important lead compound for the development of new anti-metastatic agents. ..
  46. Kandalkar S, Ramaiah P, Joshi M, Wavhal A, Waman Y, Raje A, et al. Modifications of flexible nonyl chain and nucleobase head group of (+)-erythro-9-(2's-hydroxy-3's-nonyl)adenine [(+)-EHNA] as adenosine deaminase inhibitors. Bioorg Med Chem. 2017;25:5799-5819 pubmed publisher
    ..nucleobase modified analogues of (+)-EHNA (III) were synthesized and evaluated for their ability to inhibit adenosine deaminase (ADA)...
  47. Krabbe S, Østergaard M, Eshed I, Sørensen I, Jensen B, Møller J, et al. Whole-body Magnetic Resonance Imaging in Axial Spondyloarthritis: Reduction of Sacroiliac, Spinal, and Entheseal Inflammation in a Placebo-controlled Trial of Adalimumab. J Rheumatol. 2018;45:621-629 pubmed publisher
    ..WBMRI is promising for objective assessment and monitoring of peripheral and axial disease activity in future clinical trials. ..
  48. Sakuraba M, Masuda K, Hebisawa A, Sagara Y, Komatsu H. Pleural effusion adenosine deaminase (ADA) level and occult tuberculous pleurisy. Ann Thorac Cardiovasc Surg. 2009;15:294-6 pubmed
    We investigated the incidence of tuberculous pleurisy among patients with adenosine deaminase (ADA) levels of 50 IU/L or less in a pleural effusion, and without a previous diagnosis of carcinomatous pleurisy or Mycobacterium tuberculosis...
  49. Gardner J. Standing on the shoulders of stem cell gene therapists: history, hyperbole and hope for the future. Hum Gene Ther Clin Dev. 2016;: pubmed publisher
  50. Saccucci P, Binczak Kuleta A, Banci M, Krzysztalowska M, Dofcaci A, Safranow K, et al. Coronary artery disease. A study of three polymorphic sites of adenosine deaminase gene. Acta Cardiol. 2014;69:39-44 pubmed
    ..Besides the control of adenosine concentration due to deamination of adenosine, also other functions of the ADA gene could have a role in the susceptibility and/ or clinical course of coronary artery disease. ..
  51. Li G, Nakagome I, Hirono S, Itoh T, Fujiwara R. Inhibition of adenosine deaminase (ADA)-mediated metabolism of cordycepin by natural substances. Pharmacol Res Perspect. 2015;3:e00121 pubmed publisher
    ..Our in silico study suggests that not only small molecules such as adenosine derivatives but also bulky molecules like naringin can be a potent ADA1 inhibitor for the clinical usage. ..
  52. Kuo C, Kohn D. Gene Therapy for the Treatment of Primary Immune Deficiencies. Curr Allergy Asthma Rep. 2016;16:39 pubmed publisher
    ..Clinical trials for X-linked severe combined immunodeficiency, adenosine deaminase deficiency (ADA), chronic granulomatous disease, and Wiskott-Aldrich syndrome have demonstrated that gene ..
  53. Dong K, Gao Z, Zhang H. The role of adenosinergic pathway in human autoimmune diseases. Immunol Res. 2016;64:1133-1141 pubmed
    ..In this review, we will provide a comprehensive description of the role of adenosinergic pathway in human autoimmune diseases. ..
  54. Mease P, Van den Bosch F, Sieper J, Xia Y, Pangan A, Song I. Performance of 3 Enthesitis Indices in Patients with Peripheral Spondyloarthritis During Treatment with Adalimumab. J Rheumatol. 2017;44:599-608 pubmed publisher
    ..5%, 7.0%). The LEI and SPARCC enthesitis indices showed better discriminatory capacity and treatment response in patients with pSpA versus MASES, likely because these indices contain more peripheral sites. ClinicalTrials.gov NCT01064856. ..
  55. Skolnik N, Jaffa F, Kalyani R, Johnson E, Shubrook J. Reducing CV risk in diabetes: An ADA update. J Fam Pract. 2017;66:300-308 pubmed
    ..This Q&A highlights changes to the ADA's 2017 Standards of Care to help you fine-tune your approach to patients who have, or are at risk for, atherosclerotic CV disease. ..
  56. Song B, Zuo Z, Tan J, Guo J, Teng W, Lu Y, et al. Association of thyroid nodules with adiposity: a community-based cross-sectional study in China. BMC Endocr Disord. 2018;18:3 pubmed publisher
    ..91, 95%CI 1.14-3.20), TSH >?4.2 mIU/L (OR 3.05, 95%CI 1.01-9.22), and urine iodine ?200 µg/L (OR 1.79, 95%CI 1.14-2.81). Waist circumference is superior to BMI for assessing risk of thyroid nodules in Chinese subjects. ..
  57. Liao K, Derbyshire S, Wang K, Caucci C, Tang S, Holland C, et al. Detection of Memory B Activity Against a Therapeutic Protein in Treatment-Naïve Subjects. AAPS J. 2018;20:51 pubmed publisher
    ..This novel application of a B cell ELISPOT assay informs and characterizes immune memory activity regarding incidence and magnitude associated with a pre-existing ADA response. ..
  58. da Rosa J, de Mello S, Vicente G, Moon Y, Daltoe F, Lima T, et al. Calea uniflora Less. attenuates the inflammatory response to carrageenan-induced pleurisy in mice. Int Immunopharmacol. 2017;42:139-149 pubmed publisher
    ..The following inflammatory parameters: leukocyte influx, degree of exudation, myeloperoxidase (MPO) and adenosine deaminase (ADA) activities, nitric oxide metabolites (NOx), proinflammatory cytokines and phosphorylation of the p65 ..
  59. Eidelman A, Whitmer T. Is the Advanced Dental Admission Test (ADAT) the Metric Needed to Assist with Postgraduate Admissions? Two Viewpoints: Viewpoint 1: The ADAT Provides a Viable Solution to Help Postgraduate Programs Differentiate Applicants and Viewpoint 2: The ADAT H. J Dent Educ. 2017;81:685-690 pubmed publisher
    ..In contrast, Viewpoint 2 questions the need for and appropriateness of this additional academic measure for postgraduate admissions. ..
  60. Kimura K, Kobayashi D, Hatoyama S, Yamamoto M, Takayanagi R, Yamada Y. Effects of FCGRIIIa-158V/F polymorphism on antibody-dependent cellular cytotoxicity activity of adalimumab. APMIS. 2017;: pubmed publisher
    ..05) in therapeutic concentration. The differences in therapeutic effect of ADA among individuals can be explained, in part, by ADCC activity via the FCGRIIIa-158V/F polymorphism. ..
  61. Avril A, Miethe S, Hust M, Pelat T. Construction of Macaque Immune-Libraries. Methods Mol Biol. 2018;1701:83-112 pubmed publisher
    ..This chapter presents the strategy for the construction of macaque antibody immune-libraries. ..
  62. Beyene T, Endalamaw D, Tolossa Y, Feyisa A. Evaluation of rational use of veterinary drugs especially antimicrobials and anthelmintics in Bishoftu, Central Ethiopia. BMC Res Notes. 2015;8:482 pubmed publisher
    ..Therefore, veterinary drugs, specially, antimicrobial agents should be judiciously used; and a wide scale study to safeguard the public from drug residual effects and antimicrobial resistance development is recommended. ..
  63. Lee J, Hempel J, Deng J. Anti-adenosine deaminase antibodies in lupus erythematosus. Lupus. 2002;11:168-74 pubmed
    b>Adenosine deaminase (ADA) is an enzyme involved in purine metabolism and has a major role in the development and function of lymphoid cells. Congenital deficiency of ADA results in severe immunodeficiency...
  64. Gloria Bottini F, Saccucci P, Meloni G, Bottini E. Further observations on associations between the ADA gene and past malaria morbidity in Sardinia. Am J Hum Biol. 2014;26:716-8 pubmed publisher
    b>Adenosine Deaminase (ADA) contributes to the regulation of adenosine concentration and in turn to T cell activation. Genetic variability of ADA activity may have, therefore, an important role in resistance to malaria...
  65. Dubinsky M, Phan B, Singh N, RABIZADEH S, Mould D. Pharmacokinetic Dashboard-Recommended Dosing Is Different than Standard of Care Dosing in Infliximab-Treated Pediatric IBD Patients. AAPS J. 2017;19:215-222 pubmed publisher
    ..Dashboard recommended SOC IFX dosing in a minority of patients. Dashboards will be an important tool to individualize IFX dosing to improve treatment durability. ..
  66. Rencz F, Gulacsi L, Pentek M, Gecse K, Dignass A, Halfvarson J, et al. Cost-utility of biological treatment sequences for luminal Crohn's disease in Europe. Expert Rev Pharmacoecon Outcomes Res. 2017;17:597-606 pubmed publisher
  67. Starc N, Ingo D, Conforti A, Rossella V, Tomao L, Pitisci A, et al. Biological and functional characterization of bone marrow-derived mesenchymal stromal cells from patients affected by primary immunodeficiency. Sci Rep. 2017;7:8153 pubmed publisher
    ..Our results indicate that PID-MSCs may be defective in some functional abilities; whether these defects contribute to disease pathophysiology deserves further investigation. ..
  68. Bonthron D, Markham A, Ginsburg D, Orkin S. Identification of a point mutation in the adenosine deaminase gene responsible for immunodeficiency. J Clin Invest. 1985;76:894-7 pubmed
    Deficiency of adenosine deaminase (ADA) is the cause of an autosomal recessive form of immunodeficiency...
  69. Spina C, Saccucci P, Cozzoli E, Bottini E, Gloria Bottini F. A study of three polymorphic sites of ADA gene in colon cancer. Cancer Invest. 2010;28:989-92 pubmed publisher
    Adenosine inhibits the immune response in tumors. Adenosine deaminase (ADA) controls adenosine level and as ecto-enzyme acts as costimulatory molecule of adenosine receptors and/or CD26...
  70. Bergman E, Gordon R. Position of the American Dietetic Association: local support for nutrition integrity in schools. J Am Diet Assoc. 2010;110:1244-54 pubmed
    ..A healthy school environment can be achieved through adequate funding of school meals programs and through implementation and evaluation of strong local wellness policies...
  71. Fattahi A, Khodadadi I, Amiri I, Latifi Z, Ghorbani M, Tavilani H. The Role of G22 A Adenosine Deaminase 1 Gene Polymorphism and the Activities of ADA Isoenzymes in Fertile and Infertile Men. Urology. 2015;86:730-4 pubmed publisher
    To evaluate frequency distribution of adenosine deaminase 1 (ADA1) G22 A alleles and genotypes in fertile and infertile men...
  72. Behrsin R, Junior C, Cardoso G, Barillo J, de Souza J, de Araújo E. Combined evaluation of adenosine deaminase level and histopathological findings from pleural biopsy with Cope's needle for the diagnosis of tuberculous pleurisy. Int J Clin Exp Pathol. 2015;8:7239-46 pubmed
    ..b>Adenosine deaminase (ADA) is an efficient biomarker for tuberculosis that is measurable in pleural fluids...
  73. Arainga M, Edagwa B, Mosley R, Poluektova L, Gorantla S, Gendelman H. A mature macrophage is a principal HIV-1 cellular reservoir in humanized mice after treatment with long acting antiretroviral therapy. Retrovirology. 2017;14:17 pubmed publisher
    ..Despite vigorous ART regimens, HIV-1 DNA and RNA were easily detected in mature macrophages supporting their potential role as an infectious viral reservoir. ..
  74. Catron T, Smallfield G, Kang L, Sterling R, Siddiqui M. Endoscopic Cyanoacrylate Injection with Post-injection Audible Doppler Assessment of Gastric Varices: A Single-Institution Experience. Dig Dis Sci. 2017;62:3091-3099 pubmed publisher
    ..Further prospective investigation is required to determine the impact of ADA on clinical outcomes after GV obturation. ..
  75. Sasidharan A, Kumar S, John J, Philip M, Subramanian S, Jain S, et al. Elevated serum adenosine deaminase levels in neuroleptic-naïve patients with recent-onset schizophrenia. Asian J Psychiatr. 2017;29:13-15 pubmed publisher
    The present study examined serum levels of adenosine deaminase (ADA), an adenosine metabolizing enzyme, in neuroleptic-naive patients with recent-onset schizophrenia and age-matched healthy comparison subjects...
  76. Braun J, Ruchel J, Manzoni A, Abdalla F, Casalli E, Castilhos L, et al. Pretreatment with quercetin prevents changes in lymphocytes E-NTPDase/E-ADA activities and cytokines secretion in hyperlipidemic rats. Mol Cell Biochem. 2018;444:63-75 pubmed publisher
    ..We can suggest that the quercetin is a promising compound to be used as an adjuvant in the treatment of hyperlipidemia. ..
  77. Takagaki K, Katsuma S, Kaminishi Y, Horio T, Nakagawa S, Tanaka T, et al. Gene-expression profiling reveals down-regulation of equilibrative nucleoside transporter 1 (ENT1) in Ara-C-resistant CCRF-CEM-derived cells. J Biochem. 2004;136:733-40 pubmed
    ..The adenosine deaminase (ADA) gene was highly up-regulated in Ara-C-resistant cells, while equilibrative nucleoside transporter 1 (..
  78. Kang S, Kim J, Baek J, Kim S, Kim B, Lee K, et al. Role of ascites adenosine deaminase in differentiating between tuberculous peritonitis and peritoneal carcinomatosis. World J Gastroenterol. 2012;18:2837-43 pubmed publisher
    To investigate the usefulness of tumor markers and adenosine deaminase in differentiating between tuberculous peritonitis (TBP) and peritoneal carcinomatosis (PC)...
  79. Liao Y, Wu C, Lee S, Lee C, Yang S, Chang C, et al. Adenosine deaminase activity in tuberculous peritonitis among patients with underlying liver cirrhosis. World J Gastroenterol. 2012;18:5260-5 pubmed publisher
    To investigate the value of adenosine deaminase (ADA) for early detection of tuberculous peritonitis (TBP) among cirrhotic patients. We retrospectively analyzed 22 patients with TBP from July 1990 to June 2010...
  80. Liu Y, Saccucci P, Qi H, Wu H, Zhao F, Dai Y, et al. ADA polymorphisms and asthma: a study in the Chinese Han population. J Asthma. 2006;43:203-6 pubmed
    ..Our data suggest the presence of some DNA sequences influencing the susceptibility to asthma are located in the area between ADA(1) and ADA(2) sites. ..
  81. Hill O, Scofield D, Usedom J, Bulathsinhala L, McKinnon C, Kwon P, et al. Risk Factors for Rhabdomyolysis in the U.S. Army. Mil Med. 2017;182:e1836-e1841 pubmed publisher
    ..Extended physical exertion, especially in hot environments, and trauma can precipitate RM. The aim of this study was to identify RM risk factors among U.S. Active Duty Army (ADA) Soldiers...
  82. . 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018;41:S13-S27 pubmed publisher
    ..diabetes.org/SOC...
  83. . 6. Glycemic Targets: Standards of Medical Care in Diabetes-2018. Diabetes Care. 2018;41:S55-S64 pubmed publisher
    ..diabetes.org/SOC...
  84. Yang D, Huie M, Hirschhorn R. Homozygosity for a missense mutation (G20R) associated with neonatal onset adenosine deaminase-deficient severe combined immunodeficiency (ADA-SCID). Clin Immunol Immunopathol. 1994;70:171-5 pubmed
    Mutations at the adenosine deaminase (ADA) locus can result in varying degrees of immunodeficiency, including rapidly fulminant severe combined immunodeficiency (SCID) as well as a slowly progressive immunodeficiency not diagnosed until ..
  85. Hwang Y, Chen E, Gu Z, Chuang W, Yu M, Lai M, et al. Genetic predisposition of responsiveness to therapy for chronic hepatitis C. Pharmacogenomics. 2006;7:697-709 pubmed
    ..Association studies and haplotype reconstruction revealed selection of seven genes: adenosine deaminase, RNA-specific (ADAR), caspase 5, apoptosis-related cysteine peptidase (CASP5), fibroblast growth factor 1 (..
  86. Reichert C, Maire M, Gabel V, Hofstetter M, Viola A, Kolodyazhniy V, et al. The circadian regulation of sleep: impact of a functional ADA-polymorphism and its association to working memory improvements. PLoS ONE. 2014;9:e113734 pubmed publisher
    ..Twenty-four participants were genotyped regarding a functional polymorphism in adenosine deaminase (rs73598374, 12 G/A-, 12 G/G-allele carriers), previously associated with differences in sleep-wake ..
  87. Luchetti M, Benfaremo D, Ciccia F, Bolognini L, Ciferri M, Farinelli A, et al. Adalimumab efficacy in enteropathic spondyloarthritis: A 12-mo observational multidisciplinary study. World J Gastroenterol. 2017;23:7139-7149 pubmed publisher
    ..Ada treatment, upon multidisciplinary (gastro-rheumatologic) evaluation, significantly improves both articular and gastrointestinal inflammation, thereby improving the HRQoL in patients affected by ES. ..
  88. Sokolic R, Maric I, Kesserwan C, Garabedian E, Hanson I, Dodds M, et al. Myeloid dysplasia and bone marrow hypocellularity in adenosine deaminase-deficient severe combined immune deficiency. Blood. 2011;118:2688-94 pubmed publisher
    Genetic deficiency of adenosine deaminase (ADA) can cause profound lymphopenia and result in the clinical presentation of severe combined immune deficiency (SCID)...
  89. Da Silva A, Santurio J, Roza L, Bottari N, Galli G, Morsch V, et al. Aflatoxins produced by Aspergillus parasiticus present in the diet of quails increase the activities of cholinesterase and adenosine deaminase. Microb Pathog. 2017;107:309-312 pubmed publisher
    ..effects of aflatoxins on cholinesterases (acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), and adenosine deaminase (ADA) activities in quails...
  90. Doleski P, Leal D, Machado V, Bottari N, Manzoni A, Casali E, et al. Diphenyl diselenide modulates nucleotidases, reducing inflammatory responses in the liver of Toxoplasma gondii-infected mice. Purinergic Signal. 2017;13:489-496 pubmed publisher
  91. Sánchez Navarrete J, Arriaga Alba M, Ruiz Pérez N, Toscano Garibay J. Antimutagenic activity of vitamin B1 against damages induced by chemical and physical mutagens in Salmonella typhimurium and Escherichia coli. Toxicol In Vitro. 2017;45:202-206 pubmed publisher
    ..While for E. coli, the presence of vitamin B1 increased the survival rate, implying an antimutagenesis independent of uvrABC repairing system and recBCD enzymes. ..
  92. Wang C, Weng C, Lee C, Huang K, Hsu S, Liu M. Rare occurrence of inflammatory bowel disease in a cohort of Han Chinese ankylosing spondylitis patients- a single institute study. Sci Rep. 2017;7:13165 pubmed publisher
    ..0?±?1.1 years after the adalimumab (ADA) therapy. In this retrospective cohort, we demonstrate the rarity of AS-associated IBD manifestation in Han Chinese with a beneficent effect from the ADA therapy. ..