ADD3

Summary

Gene Symbol: ADD3
Description: adducin 3
Alias: ADDL, CPSQ3, gamma-adducin, adducin 3 (gamma), adducin-like protein 70
Species: human
Products:     ADD3

Top Publications

  1. Kaiser H, O KEEFE E, Bennett V. Adducin: Ca++-dependent association with sites of cell-cell contact. J Cell Biol. 1989;109:557-69 pubmed
  2. Garcia Barcelo M, Yeung M, Miao X, Tang C, Cheng G, Chen G, et al. Genome-wide association study identifies a susceptibility locus for biliary atresia on 10q24.2. Hum Mol Genet. 2010;19:2917-25 pubmed publisher
    ..94 x 10(-9). The identification of putative BA susceptibility loci not only opens new fields of investigation into the mechanisms underlying BA but may also provide new clues for the development of preventive and curative strategies. ..
  3. Tsai E, Grochowski C, Loomes K, Bessho K, Hakonarson H, Bezerra J, et al. Replication of a GWAS signal in a Caucasian population implicates ADD3 in susceptibility to biliary atresia. Hum Genet. 2014;133:235-43 pubmed publisher
    ..2 (hg18) genomic region. This signal was upstream of two genes, XPNPEP1 and ADD3, both expressed in intrahepatic bile ducts...
  4. Cheng G, Tang C, Wong E, Cheng W, So M, Miao X, et al. Common genetic variants regulating ADD3 gene expression alter biliary atresia risk. J Hepatol. 2013;59:1285-91 pubmed publisher
    ..2 region encompassing ADD3 and XPNPEP1 genes, which was replicated in Chinese and Thai populations...
  5. Naydenov N, Ivanov A. Adducins regulate remodeling of apical junctions in human epithelial cells. Mol Biol Cell. 2010;21:3506-17 pubmed publisher
    ..These findings suggest novel roles for adducins in stabilization of epithelial junctions and regulation of junctional remodeling...
  6. Dong J, Fujita R, Zako T, Ueda H. Construction of Quenchbodies to detect and image amyloid ? oligomers. Anal Biochem. 2018;550:61-67 pubmed publisher
    ..Recent studies showed that A? oligomers, such as A?-derived diffusible ligand (ADDL), are more toxic than fibrils...
  7. Laochareonsuk W, Chiengkriwate P, Sangkhathat S. Single nucleotide polymorphisms within Adducin 3 and Adducin 3 antisense RNA1 genes are associated with biliary atresia in Thai infants. Pediatr Surg Int. 2018;34:515-520 pubmed publisher
    ..Asians suggested a genetic association between biliary atresia (BA) and a cluster of variants within the Adducin 3 (ADD3) and ADD3 antisense RNA1 (ADD3-AS1) genes...
  8. Wen J, Fang F, Guo S, Zhang Y, Peng X, Sun W, et al. Amyloid ?-Derived Diffusible Ligands (ADDLs) Induce Abnormal Autophagy Associated with A? Aggregation Degree. J Mol Neurosci. 2018;64:162-174 pubmed publisher
    ..study, we primarily defined the specific subsets of ADDLs, A-0, A-12, A-24, and A-48, which were generated from ADDL aggregation mixtures at different time courses of assembly...
  9. Herzer S, Meldner S, Rehder K, Gröne H, Nordström V. Lipid microdomain modification sustains neuronal viability in models of Alzheimer's disease. Acta Neuropathol Commun. 2016;4:103 pubmed publisher
    ..We furthermore demonstrate a molecular mechanism explaining how gangliosides mediate ADDL-related toxic effects on IR of murine neurons...

More Information

Publications36

  1. Soualmia H, Ben Romdhane A, Midani F, Kallel A, Jemaa R, Feki M, et al. Alpha Adducin G460T Variant is a Risk Factor for Hypertension in Tunisian Population. Clin Lab. 2016;62:765-70 pubmed
    ..protein, consisting of three subunits: ?, ?, and ? subunits encoded by three different genes (ADD1, ADD2, ADD3). A specific mutation G460T of the ?-adducin gene (ADD1) is associated with high renal tubular sodium reabsorption...
  2. Shi X, Sun K, Hu R, Liu X, Hu Q, Sun X, et al. Blocking the Interaction between EphB2 and ADDLs by a Small Peptide Rescues Impaired Synaptic Plasticity and Memory Deficits in a Mouse Model of Alzheimer's Disease. J Neurosci. 2016;36:11959-11973 pubmed
    ..and synthesize four candidate peptides (Pep21, Pep25, Pep32, and Pep63) that might be able to block the EphB2-ADDL interaction. Among them, Pep63 was found to be the most effective at inhibiting the binding between EphB2 and ADDLs...
  3. Tang V, COFER Z, Cui S, Sapp V, Loomes K, Matthews R. Loss of a Candidate Biliary Atresia Susceptibility Gene, add3a, Causes Biliary Developmental Defects in Zebrafish. J Pediatr Gastroenterol Nutr. 2016;63:524-530 pubmed
    ..Adducin 3 (ADD3) and X-prolyl aminopeptidase 1 (XPNPEP1) are 2 genes previously identified in genome-wide association studies as ..
  4. Manvati S, Mangalhara K, Khan J, Pathania G, Kaul S, Kaushik M, et al. Deciphering the role of microRNA - A step by step guide. Gene Expr Patterns. 2017;25-26:59-65 pubmed publisher
    ..This perspective as a guide would help in identifying novel targets for a microRNA, as shown for miR-145a-5p, which down-regulated the mRNA expression of ADD3 and BRCA2, using bioinformatic tools and experimental assays.
  5. Bosia M, Pigoni A, Zagato L, Merlino L, Casamassima N, Lorenzi C, et al. ADDing a piece to the puzzle of cognition in schizophrenia. Eur J Med Genet. 2016;59:26-31 pubmed publisher
    ..we tested 342 patients with schizophrenia for three common adducins genetic variants, ADD1 rs4961, ADD2 rs4984 and ADD3 rs3731566, reported to have significant effects on circulatory system in humans...
  6. Liu C, Hsu W, Lin W, Chen H. Adducin family proteins possess different nuclear export potentials. J Biomed Sci. 2017;24:30 pubmed publisher
    The adducin (ADD) family proteins, namely ADD1, ADD2, and ADD3, are actin-binding proteins that play important roles in the stabilization of membrane cytoskeleton and cell-cell junctions...
  7. Poon M, Zhuang J, Wong S, Sun S, Zhang X, Leung G. Co-expression of Cytoskeletal Protein Adducin 3 and CD133 in Neurospheres and a Temozolomide-resistant Subclone of Glioblastoma. Anticancer Res. 2015;35:6487-95 pubmed
    Glioma stem cells are associated for temozolomide-resistance in glioblastoma. Adducin 3 (ADD3) is a cytoskeletal protein associated with chemoresistance but its role in glioblastoma has not been investigated...
  8. Gilligan D, Lozovatsky L, Gwynn B, Brugnara C, Mohandas N, Peters L. Targeted disruption of the beta adducin gene (Add2) causes red blood cell spherocytosis in mice. Proc Natl Acad Sci U S A. 1999;96:10717-22 pubmed
    ..This study demonstrates adducin's importance to RBC membrane stability in vivo. ..
  9. Zeng S, Sun P, Chen Z, Mao J, Wang J, Wang B, et al. Association between single nucleotide polymorphisms in the ADD3 gene and susceptibility to biliary atresia. PLoS ONE. 2014;9:e107977 pubmed publisher
    Based on the results of previous studies, the ADD3 gene, located in the 10q24.2 region, may be a susceptibility gene of biliary atresia (BA)...
  10. Katagiri T, Ozaki K, Fujiwara T, Shimizu F, Kawai A, Okuno S, et al. Cloning, expression and chromosome mapping of adducin-like 70 (ADDL), a human cDNA highly homologous to human erythrocyte adducin. Cytogenet Cell Genet. 1996;74:90-5 pubmed
    From a human fetal-brain cDNA library we isolated a novel human cDNA, termed human adducin-like 70 (gene symbol ADDL), whose predicted amino acid sequence showed a high degree of homology to adducins...
  11. Charney A, Ruderfer D, Stahl E, Moran J, Chambert K, Belliveau R, et al. Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder. Transl Psychiatry. 2017;7:e993 pubmed publisher
    ..28 × 10-8) that includes the brain-enriched cytoskeleton protein adducin 3 (ADD3), a non-coding RNA, and a neuropeptide-specific aminopeptidase P (XPNPEP1)...
  12. Fan F, Pabbidi M, Ge Y, Li L, Wang S, Mims P, et al. Knockdown of Add3 impairs the myogenic response of renal afferent arterioles and middle cerebral arteries. Am J Physiol Renal Physiol. 2017;312:F971-F981 pubmed publisher
    ..Transfer of a region of chromosome 1 containing ?-adducin (Add3) from the Brown Norway rat rescued the vascular dysfunction and the development of renal disease...
  13. Russell L, Jones L, Enshaei A, Tonin S, Ryan S, Eswaran J, et al. Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia. Genes Chromosomes Cancer. 2017;56:363-372 pubmed publisher
    ..36/108, 33%, P < .001), BTG1 (11/35, 31% vs. 10/108, 9%, P =.004), and ADD3 deletions (9/19, 47% vs. 5/38, 13%, P =.008)...
  14. Ye Y, Li Z, Feng Q, Chen Z, Wu Z, Wang J, et al. Downregulation of microRNA-145 may contribute to liver fibrosis in biliary atresia by targeting ADD3. PLoS ONE. 2017;12:e0180896 pubmed publisher
    ..However, its pathology and etiology still remained unknown. In this study, we tested the expression of adducin 3 (ADD3), the gene identified as a susceptibility gene in BA by GWAS, and uncovered its upstream regulatory microRNA in the ..
  15. Lanzani C, Citterio L, Jankaricova M, Sciarrone M, Barlassina C, Fattori S, et al. Role of the adducin family genes in human essential hypertension. J Hypertens. 2005;23:543-9 pubmed
    ..Polymorphisms in the ADD2 and ADD3 genes taken alone were not associated with these variables...
  16. Kruer M, Jepperson T, Dutta S, Steiner R, Cottenie E, Sanford L, et al. Mutations in γ adducin are associated with inherited cerebral palsy. Ann Neurol. 2013;74:805-14 pubmed publisher
    ..We identified a homozygous c.1100G>A (p.G367D) mutation in ADD3, encoding gamma adducin in all affected members of the index family. Follow-up experiments in patient fibroblasts found that the p...
  17. Seidlerova J, Staessen J, Bochud M, Nawrot T, Casamassima N, Citterio L, et al. Arterial properties in relation to genetic variations in the adducin subunits in a white population. Am J Hypertens. 2009;22:21-6 pubmed publisher
    ..arterial characteristics might be related to the genes encoding ADD1 (Gly460Trp-rs4961), ADD2 (C1797T-rs4984), and ADD3 (IVS11+386A>G-rs3731566). We randomly recruited 1,126 Flemish subjects (mean age, 43.8 years; 50.3% women)...
  18. Kuznetsova T, Citterio L, Herbots L, Carpini S, Thijs L, Casamassima N, et al. Effects of genetic variation in adducin on left ventricular diastolic function as assessed by tissue Doppler imaging in a Flemish population. J Hypertens. 2008;26:1229-36 pubmed publisher
    We investigated the possible association between left ventricular diastolic function and the ADD1 Gly460Trp and ADD3 IVS11 +386A>G polymorphisms alone and in combination. In a family-based population study (473 subjects; 50...
  19. Yenerel M, Sundell I, Weese J, Bulger M, Gilligan D. Expression of adducin genes during erythropoiesis: a novel erythroid promoter for ADD2. Exp Hematol. 2005;33:758-66 pubmed
    The first objective of this study was to examine the differences in levels of adducin (ADD1, ADD2, ADD3) mRNA expression during human erythropoiesis...
  20. Rani S, Rathod S, Karthik S, Kaur N, Muzumdar D, Shiras A. MiR-145 functions as a tumor-suppressive RNA by targeting Sox9 and adducin 3 in human glioma cells. Neuro Oncol. 2013;15:1302-16 pubmed publisher
    ..of miR-145 are mediated through its target proteins Sox9 and the cell adhesion-associated molecule adducin 3 (ADD3). Inhibiting Sox9 and ADD3 rescued effects of miR-145 loss...
  21. Gilligan D, Sarid R, Weese J. Adducin in platelets: activation-induced phosphorylation by PKC and proteolysis by calpain. Blood. 2002;99:2418-26 pubmed
    ..Our results suggest that regulation of adducin function by PKC and calpain may play a role in platelet aggregation. ..
  22. Teggi R, Lanzani C, Zagato L, Delli Carpini S, Manunta P, Bianchi G, et al. Gly460Trp alpha-adducin mutation as a possible mechanism leading to endolymphatic hydrops in Ménière's syndrome. Otol Neurotol. 2008;29:824-8 pubmed publisher
    ..cytoskeleton protein consisting of 3 subunits (alpha, beta, and gamma) coded by 3 different genes (ADD1, ADD2, and ADD3)...
  23. Ishizuka Y, Hanamura K. Drebrin in Alzheimer's Disease. Adv Exp Med Biol. 2017;1006:203-223 pubmed publisher
    ..Consistent with the AD mouse models, the surface expression of glutamate receptors decreases after ADDL exposure...
  24. Dimke H, San Cristobal P, de Graaf M, Lenders J, Deinum J, Hoenderop J, et al. ?-Adducin stimulates the thiazide-sensitive NaCl cotransporter. J Am Soc Nephrol. 2011;22:508-17 pubmed publisher
    ..These data suggest that ?-adducin may influence BP homeostasis by modulating renal NaCl transport. ..
  25. Cwynar M, Staessen J, Tichá M, Nawrot T, Citterio L, Kuznetsova T, et al. Epistatic interaction between alpha- and gamma-adducin influences peripheral and central pulse pressures in white Europeans. J Hypertens. 2005;23:961-9 pubmed
    ..This epistatic interaction is physiologically consistent with the heterodimeric structure of the protein and its influence on transmembranous sodium transport. ..
  26. Citterio L, Azzani T, Duga S, Bianchi G. Genomic organization of the human gamma adducin gene. Biochem Biophys Res Commun. 1999;266:110-4 pubmed
    We report the genomic structure of the human gamma adducin gene (ADD3). Adducin is a protein involved in cytoskeletal assembly and composed of alpha-beta or alpha-gamma subunits which share a high degree of homology between human and rat...
  27. Gocke C, Yu H, Kang J. Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. J Biol Chem. 2005;280:5004-12 pubmed
    ..Therefore, sumoylation appears to regulate the functions of its substrates through multiple, context-dependent mechanisms. ..