ADCYAP1R1

Summary

Gene Symbol: ADCYAP1R1
Description: ADCYAP receptor type I
Alias: PAC1, PAC1R, PACAPR, PACAPRI, pituitary adenylate cyclase-activating polypeptide type I receptor, PACAP receptor 1, PACAP type I receptor, PACAP-R1, adenylate cyclase activating polypeptide 1 (pituitary) receptor type I, pituitary adenylate cyclase activating polypeptide 1 receptor type I Hiphop, pituitary adenylate cyclase-activating polypeptide type 1 receptor
Species: human
Products:     ADCYAP1R1

Top Publications

  1. Ergang P, Vodička M, Soták M, Klusoňová P, Behuliak M, Řeháková L, et al. Differential impact of stress on hypothalamic-pituitary-adrenal axis: gene expression changes in Lewis and Fisher rats. Psychoneuroendocrinology. 2015;53:49-59 pubmed publisher
    ..The upregulation of PACAP and CRH was paralleled only by increased expression of PACAP receptor PAC1 but not CRH receptor type 1...
  2. Telegdy G, Adamik A. Neurotransmitter-mediated anxiogenic action of PACAP-38 in rats. Behav Brain Res. 2015;281:333-8 pubmed publisher
    ..the animals with various receptor blockers indicated that a nonselective dopaminergic receptor antagonist, 5HT2 serotonergic and opioid receptors, nitric oxide and PAC1 receptors are involved in the anxiogenic action induced by PACAP-38.
  3. Zhao C, Kodama Y, Flatberg A, Beisvag V, Kulseng B, Sandvik A, et al. Gene expression profiling of gastric mucosa in mice lacking CCK and gastrin receptors. Regul Pept. 2014;192-193:35-44 pubmed publisher
    ..was associated with an up-regulated pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1)...
  4. Tan Y, Abad C, Wang Y, Lopez R, Waschek J. VPAC2 (vasoactive intestinal peptide receptor type 2) receptor deficient mice develop exacerbated experimental autoimmune encephalomyelitis with increased Th1/Th17 and reduced Th2/Treg responses. Brain Behav Immun. 2015;44:167-175 pubmed publisher
    ..what are the specific immunoregulatory roles played by each of their receptor subtypes (VPAC1, VPAC2, and PAC1) is critical...
  5. Mahata M, Zhang K, Gayen J, Nandi S, Brar B, Ghosh S, et al. Catecholamine biosynthesis and secretion: physiological and pharmacological effects of secretin. Cell Tissue Res. 2011;345:87-102 pubmed publisher
    ..PC12 cells, but this was inhibited by pre-treatment with VIP-preferring receptor (VPAC1)/PACAP-preferring receptor (PAC1) antagonists...
  6. Moldovan Loomis C, Dutzar B, Ojala E, Hendrix L, Karasek C, Scalley Kim M, et al. Pharmacologic Characterization of ALD1910, a Potent Humanized Monoclonal Antibody against the Pituitary Adenylate Cyclase-Activating Peptide. J Pharmacol Exp Ther. 2019;369:26-36 pubmed publisher
    ..3 mg/kg. These results indicate that ALD1910 represents a potential therapeutic antibody to address PACAP-mediated migraine. ..
  7. Sakamoto K, Koyama R, Kamada Y, Miwa M, Tani A. Discovery of artificial VIPR2-antagonist peptides possessing receptor- and ligand-selectivity. Biochem Biophys Res Commun. 2018;503:1973-1979 pubmed publisher
    ..subtypes VIPR1 (also known as VPAC1) and pituitary adenylate cyclase-activating polypeptide type-1 receptor (PAC1)...
  8. Chaurasiya S, Hew P, Crosley P, Sharon D, Potts K, Agopsowicz K, et al. Breast cancer gene therapy using an adenovirus encoding human IL-2 under control of mammaglobin promoter/enhancer sequences. Cancer Gene Ther. 2016;23:178-87 pubmed publisher
    ..Both IL-2 vectors exerted significant tumor growth delay; however, attempts to further enhance antitumor activity of the IL-2 vectors by combining with the proapoptotic drug procaspase activating compound 1 (PAC1) were unsuccessful.
  9. Lin C, Bai J, He M, Wong A. Grass Carp Prolactin Gene: Structural Characterization and Signal Transduction for PACAP-induced Prolactin Promoter Activity. Sci Rep. 2018;8:4655 pubmed publisher
    ..These results suggest that PACAP can stimulate PRL promoter activation by PAC1 mediated functional coupling of the Ca2+/CaM/CaM kinase II cascades with the AC/cAMP/PKA pathway...

More Information

Publications148 found, 100 shown here

  1. Miles O, May V, Hammack S. Pituitary Adenylate Cyclase-Activating Peptide (PACAP) Signaling and the Dark Side of Addiction. J Mol Neurosci. 2018;: pubmed publisher
    ..Similar to footshock stress, the BNST administration of PACAP or the PAC1 receptor-specific agonist maxadilan can facilitate relapse following extinction of cocaine-seeking behavior...
  2. Tozawa K, Ono Uruga Y, Yazawa M, Mori T, Murata M, Okamoto S, et al. Unique megakaryocytes and platelets from novel human adipose-derived mesenchymal stem cell line. Blood. 2018;: pubmed publisher
    ..Compared with peripheral platelets, ASCL-PLT exhibits higher levels of PAC1 binding, P-selectin surface exposure, ristocetin-induced platelet aggregation, and ADP-induced platelet aggregation;..
  3. Santos López G, Borraz Argüello M, Márquez Domínguez L, Flores Alonso J, Ramírez Mendoza H, Priem B, et al. Neuraminidase activity of blue eye disease porcine rubulavirus: Specificity, affinity and inhibition studies. Res Vet Sci. 2017;114:218-224 pubmed publisher
    ..This work describes the purification and characterization of PorPV HN protein (isolate PAC1). The specificity of neuraminidase is restricted to sialyl(α2,3)lactose (3SL)...
  4. Bondu V, Wu C, Cao W, Simons P, Gillette J, Zhu J, et al. Low-affinity binding in cis to P2Y2R mediates force-dependent integrin activation during hantavirus infection. Mol Biol Cell. 2017;28:2887-2903 pubmed publisher
    ..recapitulates physiologic activation of the integrin as indicated by staining with the activation-specific mAB PAC1. The data also show that blocking of the Gα13 protein from binding to the cytoplasmic domain of the Î..
  5. Ortiz Urquiza A, Keyhani N. Stress response signaling and virulence: insights from entomopathogenic fungi. Curr Genet. 2015;61:239-49 pubmed publisher
    ..g. Msn2, CreA and Pac1. Here, we will discuss current research that strongly suggests extensive underlying contributions of these ..
  6. Juhász T, Szentléleky E, Somogyi C, Takács R, Dobrosi N, Engler M, et al. Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) Pathway Is Induced by Mechanical Load and Reduces the Activity of Hedgehog Signaling in Chondrogenic Micromass Cell Cultures. Int J Mol Sci. 2015;16:17344-67 pubmed publisher
    ..Expressions of the mRNAs of PACAP and its major receptor, PAC1 increased, while that of other receptors, VPAC1, VPAC2 decreased upon mechanical stimulus...
  7. Agüero Chapin G, Pérez Machado G, Mull J, Ancede Gallardo E, Antunes A, Riva G. How the Protein Architecture of RNases III Influences their Substrate Specificity?. Curr Pharm Des. 2016;22:5065-5071 pubmed
    ..enzymatic activity of three RNase III members from class I (Escherichia coli RNase III, Schizosaccharomyces pombe Pac1 and Saccharomyces cerevisiae Rntp1) and the human Drosha placed in class II was revisited against four different ..
  8. Pecoraro V, Sardone L, Chisari M, Licata F, Li Volsi G, Perciavalle V, et al. A subnanomolar concentration of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) pre-synaptically modulates glutamatergic transmission in the rat hippocampus acting through acetylcholine. Neuroscience. 2017;340:551-562 pubmed publisher
    ..The effect of subnanomolar PACAP was abolished by a PAC1 receptor antagonist but not by a VPAC receptor blocker...
  9. Samblas M, Milagro F, Mansego M, Marti A, Martinez J. PTPRS and PER3 methylation levels are associated with childhood obesity: results from a genome-wide methylation analysis. Pediatr Obes. 2018;13:149-158 pubmed publisher
    ..Moreover, the DNA methylation levels of VIPR2, GRIN2D, ADCYAP1R1, PER3 and PTPRS regions correlated with the obesity trait...
  10. Atlasz T, Werling D, Song S, Szabo E, Vaczy A, Kovari P, et al. Retinoprotective Effects of TAT-Bound Vasoactive Intestinal Peptide and Pituitary Adenylate Cyclase Activating Polypeptide. J Mol Neurosci. 2018;: pubmed publisher
    ..effects when given in eye drops, by increasing the traversing efficacy and enhancing the activation of the PAC1 receptor...
  11. Hirasawa H, Shioya K, Mori K, Tashiro K, Aburatani S, Shida Y, et al. Cellulase productivity of Trichoderma reesei mutants developed in Japan varies with varying pH conditions. J Biosci Bioeng. 2019;: pubmed publisher
    ..Furthermore, the deletion of pac1 encoding PACI caused different expression patterns of cellulase genes between QM9414 and PC-3-7...
  12. Marzagalli R, Leggio G, Bucolo C, Pricoco E, Keay K, Cardile V, et al. Genetic blockade of the dopamine D3 receptor enhances hippocampal expression of PACAP and receptors and alters their cortical distribution. Neuroscience. 2016;316:279-95 pubmed publisher
    ..Consistently, PAC1, VPAC1 and VPAC2 IRs were variably redistributed in CX, with a general upregulation in cortical layers II-IV in ..
  13. Bhandare A, Kapoor K, Farnham M, Pilowsky P. Microglia PACAP and glutamate: Friends or foes in seizure-induced autonomic dysfunction and SUDEP?. Respir Physiol Neurobiol. 2016;226:39-50 pubmed publisher
    ..Seizure-induced increase in PACAP is neuroprotective. PACAP produces neuroprotective effects acting on microglial PAC1 and VPAC1 receptors...
  14. Wang L, Qiu P, Jiao J, Hirai H, Xiong W, Zhang J, et al. Yes-Associated Protein Inhibits Transcription of Myocardin and Attenuates Differentiation of Vascular Smooth Muscle Cell from Cardiovascular Progenitor Cell Lineage. Stem Cells. 2017;35:351-361 pubmed publisher
    ..Importantly, expression of YAP decreased transcription of myocardin during this process. Overexpression of YAP in PAC1 SMC cell line inhibited luciferase activity of myocardin proximal promoter in a dose dependent and NKX2...
  15. Abad C, Tan Y. Immunomodulatory Roles of PACAP and VIP: Lessons from Knockout Mice. J Mol Neurosci. 2018;66:102-113 pubmed publisher
    ..neuropeptides (Vip and Adcyap1) or for their G-protein-coupled receptors VPAC1, VPAC2, and PAC1 (Vipr1, Vipr2, Adcyap1r1) has allowed to address this question, underscoring the complexity of the immunoregulatory properties of PACAP ..
  16. Guillén Burgos H, Gutiérrez Ruiz K. Genetic Advances in Post-traumatic Stress Disorder. Rev Colomb Psiquiatr. 2018;47:108-118 pubmed publisher
    ..These studies have included genes such as SLC64A, FKBP5, and ADCYAP1R1, among others...
  17. Bacchelli E, Cainazzo M, Cameli C, Guerzoni S, Martinelli A, Zoli M, et al. A genome-wide analysis in cluster headache points to neprilysin and PACAP receptor gene variants. J Headache Pain. 2016;17:114 pubmed
    ..1?×?10-6) with a common variant of the PACAP receptor gene (ADCYAP1R1). Furthermore, gene-based analysis provided significant evidence of association (P?=?2...
  18. King S, Toufexis D, Hammack S. Pituitary adenylate cyclase activating polypeptide (PACAP), stress, and sex hormones. Stress. 2017;20:465-475 pubmed publisher
    ..In this review, we describe the role of the PACAP/PAC1 system in stress biology, focusing on the role of stress-induced alterations in PACAP expression and signaling in ..
  19. Babenko V, Bragin A, Chadaeva I, Markel A, Orlov Y. [Differential alternative splicing in brain regions of rats selected for aggressive behavior]. Mol Biol (Mosk). 2017;51:870-880 pubmed publisher
    ..For the Adcyap1r1 gene, five alternatively spliced mRNA isoforms have been represented differentially in aggressive animals...
  20. Xiong Y, Guo J, Candelore M, Liang R, Miller C, Dallas Yang Q, et al. Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes. J Med Chem. 2012;55:6137-48 pubmed publisher
    ..for glucagon receptor relative to other family B GPCRs, showing IC(50) values of 1020 nM for GIPR, 9200 nM for PAC1, and >10000 nM for GLP-1R, VPAC1, and VPAC2...
  21. de Boisvilliers M, Perrin F, Hebache S, Balandre A, Bensalma S, Garnier A, et al. VIP and PACAP analogs regulate therapeutic targets in high-risk neuroblastoma cells. Peptides. 2016;78:30-41 pubmed publisher
    ..SK-NDZ and Kelly cells expressed the genes encoding the 3 subtypes of VIP and PACAP receptors, VPAC1, VPAC2 and PAC1. In parallel to its effect on MYCN expression, VIP inhibited invasion in IMR-32 and Kelly cells...
  22. Lu D, Liu L, Ji X, Gao Y, Chen X, Liu Y, et al. The phosphatase DUSP2 controls the activity of the transcription activator STAT3 and regulates TH17 differentiation. Nat Immunol. 2015;16:1263-73 pubmed publisher
    ..Here we found that the phosphatase DUSP2 (PAC1) negatively regulated the development of TH17 cells...
  23. Mai H, Chung Y, Shin E, Sharma N, Jeong J, Jang C, et al. IL-6 knockout mice are protected from cocaine-induced kindling behaviors; possible involvement of JAK2/STAT3 and PACAP signalings. Food Chem Toxicol. 2018;116:249-263 pubmed publisher
    ..Cocaine-treated IL-6 knockout mice exhibited significantly decreased PACAP and PACAP receptor (PAC1R) mRNA levels and significantly increased TNF-? gene expression...
  24. Reglodi D, Tamas A, Jungling A, Vaczy A, Rivnyak A, Fulop B, et al. Protective effects of pituitary adenylate cyclase activating polypeptide against neurotoxic agents. Neurotoxicology. 2018;66:185-194 pubmed publisher
    ..PACAP has been shown to activate several protective pathways, mainly through its specific PAC1 receptor and protein kinase A, C and MAP kinases downstream...
  25. Sabato D, Lionetto L, Martelletti P. The therapeutic potential of novel anti-migraine acute therapies. Expert Opin Investig Drugs. 2015;24:141-4 pubmed publisher
    ..including: 5-HT receptors and their agonists, calcitonin gene-related peptide receptors and their antagonists, PAC1 receptors and their antagonists, glutamate receptors and some of their antagonists as well as transient receptor ..
  26. Hirabayashi T, Nakamachi T, Shioda S. Discovery of PACAP and its receptors in the brain. J Headache Pain. 2018;19:28 pubmed publisher
    ..of the amino acid sequences of PACAP and VIP, these peptides share three class B-G-protein coupled receptors: the PAC1-Receptor (PAC1-R), the VPAC1-Receptor (VPAC1-R) and VPAC2-Receptor (VPAC2-R)...
  27. Gherghina F, Tica A, Deliu E, Abood M, Brailoiu G, Brailoiu E. Effects of VPAC1 activation in nucleus ambiguus neurons. Brain Res. 2017;1657:297-303 pubmed publisher
    The pituitary adenylyl cyclase-activating polypeptide (PACAP) and its G protein-coupled receptors, PAC1, VPAC1 and VPAC2 form a system involved in a variety of biological processes...
  28. Reglodi D, Kiss P, Lubics A, Tamas A. Review on the protective effects of PACAP in models of neurodegenerative diseases in vitro and in vivo. Curr Pharm Des. 2011;17:962-72 pubmed
    ..polypeptide (PACAP) is a pleiotropic and multifunctional peptide exerting its effects via 3 main receptors (PAC1, VPAC1 and VPAC2). PACAP is now considered to be a potent neurotrophic and neuroprotective peptide...
  29. Ogata K, Shintani N, Hayata Takano A, Kamo T, Higashi S, Seiriki K, et al. PACAP enhances axon outgrowth in cultured hippocampal neurons to a comparable extent as BDNF. PLoS ONE. 2015;10:e0120526 pubmed publisher
    ..indicate that in primary cultured hippocampal neurons, PACAP shows morphological actions via its cognate receptor PAC1, stimulating neurite length and number, and soma size to a comparable extent as BDNF, and that the increase in ..
  30. Krajcs N, Hernádi L, Pirger Z, Reglődi D, Tóth G, Kiss T. PACAP Modulates Acetylcholine-Elicited Contractions at Nicotinic Neuromuscular Contacts of the Land Snail. J Mol Neurosci. 2015;57:492-500 pubmed publisher
    ..Using immunohistochemistry, we show that PACAP and PAC1 receptors are present in nerve fibers innervating the flexor muscles but not in the muscle itself...
  31. Kurimoto E, Satoh T, Ito Y, Ishihara E, Okamoto K, Yagi Utsumi M, et al. Crystal structure of human proteasome assembly chaperone PAC4 involved in proteasome formation. Protein Sci. 2017;26:1080-1085 pubmed publisher
    ..e., proteasome-assembling chaperons 1-4 (PAC1-4) and proteasome maturation protein (POMP)...
  32. Koves K, Kántor O, Lakatos A, Szabó E, Kirilly E, Heinzlmann A, et al. Advent and recent advances in research on the role of pituitary adenylate cyclase-activating polypeptide (PACAP) in the regulation of gonadotropic hormone secretion of female rats. J Mol Neurosci. 2014;54:494-511 pubmed publisher
    ..PACAP (ADCYAP1) was isolated from ovine hypothalami. PACAP activates three distinct receptor types: G-protein coupled PAC1, VPAC1, and VPAC2 with seven transmembrane domains. Eight splice variants of PAC1 receptor are described...
  33. Lin C, Chiu L, Lee H, Chiang C, Liu S, Hsu Y, et al. PACAP38/PAC1 signaling induces bone marrow-derived cells homing to ischemic brain. Stem Cells. 2015;33:1153-72 pubmed publisher
    ..pituitary adenylate cyclase-activating peptide 38 (PACAP38), which in turn activates PACAP type 1 receptor (PAC1) under hypoxia in vitro and cerebral ischemia in vivo...
  34. Lieu S, Oh D, Pisegna J, Germano P. Neuroendocrine tumors express PAC1 receptors. Ann N Y Acad Sci. 2006;1070:399-404 pubmed
    ..The current article demonstrates that the high-affinity PAC1 receptor is expressed on the NET cell line BON...
  35. Yon L, Breault L, Contesse V, Bellancourt G, Delarue C, Fournier A, et al. Localization, characterization, and second messenger coupling of pituitary adenylate cyclase-activating polypeptide receptors in the fetal human adrenal gland during the second trimester of gestation. J Clin Endocrinol Metab. 1998;83:1299-305 pubmed
    ..The present results suggest that PACAP could be involved in the regulation of the human adrenochromaffin cells during ontogenesis. ..
  36. Heppner T, Hennig G, Nelson M, May V, Vizzard M. PACAP38-Mediated Bladder Afferent Nerve Activity Hyperexcitability and Ca2+ Activity in Urothelial Cells from Mice. J Mol Neurosci. 2018;: pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP; Adcyap1) and its cognate PAC1 receptor (Adcyap1r1) have tissue-specific distributions in the lower urinary tract (LUT)...
  37. Geng X, Sha J, Liu S, Bao L, Zhang J, Wang R, et al. A genome-wide association study in catfish reveals the presence of functional hubs of related genes within QTLs for columnaris disease resistance. BMC Genomics. 2015;16:196 pubmed publisher
    ..Within this region, five have known functions in immunity, including pik3r3b, cyld-like, adcyap1r1, adcyap1r1-like, and mast2...
  38. Han P, Caselli R, Baxter L, Serrano G, Yin J, Beach T, et al. Association of pituitary adenylate cyclase-activating polypeptide with cognitive decline in mild cognitive impairment due to Alzheimer disease. JAMA Neurol. 2015;72:333-9 pubmed publisher
    ..We measured PACAP and its receptor (PAC1) levels using enzyme-linked immunoassay. A total of 35 cases were included...
  39. Holighaus Y, Mustafa T, Eiden L. PAC1hop, null and hip receptors mediate differential signaling through cyclic AMP and calcium leading to splice variant-specific gene induction in neural cells. Peptides. 2011;32:1647-55 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP)-mediated activation of its G protein-coupled receptor PAC1 results in activation of the two G proteins Gs and Gq to alter second messenger generation and gene transcription in the ..
  40. Manavalan S, Getachew B, Manaye K, Khundmiri S, Csoka A, McKinley R, et al. PACAP Protects Against Ethanol and Nicotine Toxicity in SH-SY5Y Cells: Implications for Drinking-Smoking Co-morbidity. Neurotox Res. 2017;32:8-13 pubmed publisher
    ..or the combination of low alcohol and nicotine concentrations, and if so, whether this effect was mediated via PAC1 receptor...
  41. Juhász T, Matta C, Katona Ã, Somogyi C, Takács R, Hajdú T, et al. Pituitary adenylate cyclase-activating polypeptide (PACAP) signalling enhances osteogenesis in UMR-106 cell line. J Mol Neurosci. 2014;54:555-73 pubmed publisher
    ..kinase A (PKA) signalling via binding to pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1), vasoactive intestinal polypeptide receptor (VPAC) 1 or VPAC2 receptor...
  42. Fukuchi M, Kuwana Y, Tabuchi A, Tsuda M. Balance between cAMP and Ca(2+) signals regulates expression levels of pituitary adenylate cyclase-activating polypeptide gene in neurons. Genes Cells. 2016;21:921-9 pubmed publisher
    Mice lacking the gene encoding pituitary adenylate cyclase-activating polypeptide (PACAP) or its specific receptor, PAC1, show abnormal behaviors related to schizophrenia...
  43. Ivic I, Fulop B, Juhasz T, Reglodi D, Toth G, Hashimoto H, et al. Backup Mechanisms Maintain PACAP/VIP-Induced Arterial Relaxations in Pituitary Adenylate Cyclase-Activating Polypeptide-Deficient Mice. J Vasc Res. 2017;54:180-192 pubmed publisher
    ..The specific PAC1R and VPAC1R antagonist completely blocked the PACAP-induced relaxations...
  44. Aragam N, Wang K, Pan Y. Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples. J Affect Disord. 2011;133:516-21 pubmed publisher
    ..These results provide genetic basis for gender differences in MDD and will serve as a resource for replication in other populations to elucidate the potential role of these genetic variants in MDD. ..
  45. Castorina A, Waschek J, Marzagalli R, Cardile V, Drago F. PACAP interacts with PAC1 receptors to induce tissue plasminogen activator (tPA) expression and activity in schwann cell-like cultures. PLoS ONE. 2015;10:e0117799 pubmed publisher
    ..Such effect was mimicked by maxadilan, a potent PAC1 receptor agonist, but not by the PACAP-related homolog VIP, suggesting a PAC1-mediated function...
  46. Missig G, Mei L, Vizzard M, Braas K, Waschek J, Ressler K, et al. Parabrachial Pituitary Adenylate Cyclase-Activating Polypeptide Activation of Amygdala Endosomal Extracellular Signal-Regulated Kinase Signaling Regulates the Emotional Component of Pain. Biol Psychiatry. 2017;81:671-682 pubmed publisher
    ..Pituitary adenylate cyclase-activating polypeptide (PACAP; Adcyap1) and its cognate PAC1 receptor (Adcyap1r1) are expressed in peripheral nociceptive pathways, participate in anxiety-related responses and have been have ..
  47. Emery A, Liu X, Xu W, Eiden M, Eiden L. Cyclic Adenosine 3',5'-Monophosphate Elevation and Biological Signaling through a Secretin Family Gs-Coupled G Protein-Coupled Receptor Are Restricted to a Single Adenylate Cyclase Isoform. Mol Pharmacol. 2015;87:928-35 pubmed publisher
    ..challenged with the endogenous agonist of the pituitary adenylate cyclase-activating polypeptide type I receptor (PAC1), pituitary adenylate cyclase-activating polypeptide (PACAP)-38, or the diterpene forskolin as an AC-proximal ..
  48. Lutz E, Ronaldson E, Shaw P, Johnson M, Holland P, Mitchell R. Characterization of novel splice variants of the PAC1 receptor in human neuroblastoma cells: consequences for signaling by VIP and PACAP. Mol Cell Neurosci. 2006;31:193-209 pubmed
    Expression of VPAC and PAC1 receptor isoforms was determined in six neuroblastoma cell lines as well as in human embryonic and adult brain using reverse transcriptase PCR and quantitative PCR...
  49. Hamamura K, Nishimura A, Chen A, Takigawa S, Sudo A, Yokota H. Salubrinal acts as a Dusp2 inhibitor and suppresses inflammation in anti-collagen antibody-induced arthritis. Cell Signal. 2015;27:828-35 pubmed publisher
    Dual-specificity phosphatase 2 (Dusp2; also called phosphatase of activated cells 1, PAC1) is highly expressed in activated immune cells...
  50. Ohnou T, Yokai M, Kurihara T, Hasegawa Moriyama M, Shimizu T, Inoue K, et al. Pituitary adenylate cyclase-activating polypeptide type 1 receptor signaling evokes long-lasting nociceptive behaviors through the activation of spinal astrocytes in mice. J Pharmacol Sci. 2016;130:194-203 pubmed publisher
    ..long-lasting nociceptive behaviors for more than 60 min in mice, while the involvement of PACAP type1 receptor (PAC1-R) has not been clarified yet...
  51. Suntsova E, Demina I, Ignatova A, Ershov N, Trubina N, Dobrynina J, et al. Bleeding tendency and platelet function during treatment with romiplostim in children with severe immune thrombocytopenic purpura. Int J Hematol. 2017;105:841-848 pubmed publisher
    ..Levels of CD42b, PAC1, and CD62P, but not CD61 or annexin V, were significantly increased (P < 0...
  52. Van C, Condro M, Lov K, Zhu R, Ricaflanca P, Ko H, et al. PACAP/PAC1 Regulation of Inflammation via Catecholaminergic Neurons in a Model of Multiple Sclerosis. J Mol Neurosci. 2018;: pubmed publisher
    ..used an inducible, targeted approach to conditionally disrupt not only the PACAP-preferring PAC1 receptor gene (adcyap1r1) in dopamine β-hydroxylase-expressing cells, which includes postganglionic sympathetic neurons, but also ..
  53. Tompkins J, Merriam L, Girard B, May V, Parsons R. Nickel suppresses the PACAP-induced increase in guinea pig cardiac neuron excitability. Am J Physiol Cell Physiol. 2015;308:C857-66 pubmed publisher
    ..PACAP/PAC1 receptor signaling increases excitability of neurons within the guinea pig cardiac ganglia, making them a unique ..
  54. Parsons R, May V. PACAP-Induced PAC1 Receptor Internalization and Recruitment of Endosomal Signaling Regulate Cardiac Neuron Excitability. J Mol Neurosci. 2018;: pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP, Adcyap1) activation of PAC1 receptors (Adcyap1r1) significantly increases excitability of guinea pig cardiac neurons...
  55. Sághy Ã, Payrits M, Helyes Z, ReglÅ‘di D, Bánki E, Tóth G, et al. Stimulatory effect of pituitary adenylate cyclase-activating polypeptide 6-38, M65 and vasoactive intestinal polypeptide 6-28 on trigeminal sensory neurons. Neuroscience. 2015;308:144-56 pubmed publisher
    Pituitary adenylate cyclase-activating polypeptide (PACAP) acts on G protein-coupled receptors: the specific PAC1 and VPAC1/VPAC2 receptors...
  56. Tompkins J, Clason T, Hardwick J, Girard B, Merriam L, May V, et al. Activation of MEK/ERK signaling contributes to the PACAP-induced increase in guinea pig cardiac neuron excitability. Am J Physiol Cell Physiol. 2016;311:C643-C651 pubmed publisher
    ..cyclase (PAC)-activating polypeptide (PACAP) peptides (Adcyap1) signaling at the selective PAC1 receptor (Adcyap1r1) participate in multiple homeostatic and stress-related responses, yet the cellular mechanisms underlying PACAP ..
  57. Uddin M, Chang S, Zhang C, Ressler K, Mercer K, Galea S, et al. Adcyap1r1 genotype, posttraumatic stress disorder, and depression among women exposed to childhood maltreatment. Depress Anxiety. 2013;30:251-8 pubmed publisher
    ..Recent work also suggests that molecular variation at the ADCYAP1R1 locus is associated with posttraumatic stress disorder (PTSD) in women...
  58. Yokai M, Kurihara T, Miyata A. Spinal astrocytic activation contributes to both induction and maintenance of pituitary adenylate cyclase-activating polypeptide type 1 receptor-induced long-lasting mechanical allodynia in mice. Mol Pain. 2016;12: pubmed publisher
    ..We have previously reported that a single intrathecal injection of PACAP or a PACAP specific (PAC1) receptor selective agonist, maxadilan, in mice induced dose-dependent aversive behaviors, which lasted more than ..
  59. Nakamachi T, Ohtaki H, Seki T, Yofu S, Kagami N, Hashimoto H, et al. PACAP suppresses dry eye signs by stimulating tear secretion. Nat Commun. 2016;7:12034 pubmed publisher
    ..PACAP immunoreactivity is co-localized with a neuronal marker, and PACAP receptor (PAC1-R) immunoreactivity is observed in mouse infraorbital lacrimal gland acinar cells...
  60. Xu Z, Ohtaki H, Watanabe J, Miyamoto K, Murai N, Sasaki S, et al. Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor. Sci Rep. 2016;6:22373 pubmed publisher
    ..This study assessed the expression of a PACAP-specific receptor (PAC1) gene and protein in mouse bone marrow (BM)...
  61. Kovács Valasek A, Szabadfi K, Denes V, Szalontai B, Tamas A, Kiss P, et al. Accelerated retinal aging in PACAP knock-out mice. Neuroscience. 2017;348:1-10 pubmed publisher
    ..showed no substantial alterations compared to young adult WT retinas, except for the specific PACAP receptor (PAC1-R) staining...
  62. Hannibal J, Georg B, Fahrenkrug J. PAC1- and VPAC2 receptors in light regulated behavior and physiology: Studies in single and double mutant mice. PLoS ONE. 2017;12:e0188166 pubmed publisher
    ..cyclase activating polypeptide (PACAP) and vasoactive intestinal polypeptide (VIP) and their receptors, the PAC1 -and the VPAC2 receptors, are involved in regulation of the circadian timing system...
  63. Jansen Olesen I, Hougaard Pedersen S. PACAP and its receptors in cranial arteries and mast cells. J Headache Pain. 2018;19:16 pubmed publisher
    ..This implicates the pituitary adenylate cyclase activating peptide type I receptor (PAC1) to be involved in the pathophysiology of PACAP1-38 provoked headaches...
  64. Stoffel M, Espinosa R, Trabb J, Le Beau M, Bell G. Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7. Genomics. 1994;23:697-9 pubmed
    The gene encoding the human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R1) was mapped to chromosome 7 by PCR analysis of genomic DNA from a human/rodent somatic cell hybrid mapping panel...
  65. Vu J, Goyal D, Luong L, Oh S, Sandhu R, Norris J, et al. PACAP intraperitoneal treatment suppresses appetite and food intake via PAC1 receptor in mice by inhibiting ghrelin and increasing GLP-1 and leptin. Am J Physiol Gastrointest Liver Physiol. 2015;309:G816-25 pubmed publisher
    ..studied PACAP's effect on appetite and food intake control by analyzing feeding behavior and metabolic hormones in PAC1-deficient (PAC1-/-) and age-matched wild-type (WT) mice intraperitoneally injected with PACAP1-38 or PACAP1-27 ..
  66. Clason T, Girard B, May V, Parsons R. Activation of MEK/ERK Signaling by PACAP in Guinea Pig Cardiac Neurons. J Mol Neurosci. 2016;59:309-16 pubmed publisher
    ..polypeptide (VIP), increased cardiac neuron pERK, implicating primary roles for PACAP-selective PAC1 receptor (Adcyap1r1) signaling rather than VPAC receptors (Vipr1 and Vipr2) in the generation of cardiac neuron pERK...
  67. Girard B, Malley S, Mathews M, May V, Vizzard M. Intravesical PAC1 Receptor Antagonist, PACAP(6-38), Reduces Urinary Bladder Frequency and Pelvic Sensitivity in NGF-OE Mice. J Mol Neurosci. 2016;59:290-9 pubmed publisher
    ..in NGF-OE mice such as neuropeptide/receptor systems including PACAP(Adcyap1) and PAC1 receptor (Adcyap1r1)...
  68. Lin C, Jiang X, He M, Zhao L, Huang T, Bian Z, et al. Mechanisms for PACAP-induced prolactin gene expression in grass carp pituitary cells. J Endocrinol. 2017;233:37-51 pubmed publisher
    ..Using RT-PCR, PACAP-selective PAC1 receptor was detected in carp lactotrophs...
  69. Steinhoff M, McGregor G, Radleff Schlimme A, Steinhoff A, Jarry H, Schmidt W. Identification of pituitary adenylate cyclase activating polypeptide (PACAP) and PACAP type 1 receptor in human skin: expression of PACAP-38 is increased in patients with psoriasis. Regul Pept. 1999;80:49-55 pubmed
    ..Using RT-PCR, the expression of a high-affinity PACAP-1 receptor in human skin was observed. These results indicate a possible role for PACAP-38 in inflammatory processes of psoriasis. ..
  70. Jeanneteau F, Chao M. Promoting neurotrophic effects by GPCR ligands. Novartis Found Symp. 2006;276:181-9; discussion 189-92, 233-7, 275-81 pubmed
    ..If small-molecule GPCR ligands can ameliorate neuronal cell loss through Trk, transactivation may offer a new strategy for promoting trophic effects during neurodegeneration. ..
  71. Dejda A, Bourgault S, Doan N, Letourneau M, Couvineau A, Vaudry H, et al. Identification by photoaffinity labeling of the extracellular N-terminal domain of PAC1 receptor as the major binding site for PACAP. Biochimie. 2011;93:669-77 pubmed publisher
    ..polypeptide (PACAP) exerts many crucial biological functions through the interaction with its specific PAC1 receptor (PAC1-R), a class B G protein-coupled receptor (GPCR)...
  72. Lee W, Kim Y, Park J, Shim S, Lee J, Hong S, et al. iRhom1 regulates proteasome activity via PAC1/2 under ER stress. Sci Rep. 2015;5:11559 pubmed publisher
    ..iRhom1 interacted with the 20S proteasome assembly chaperones PAC1 and PAC2, affecting their protein stability...
  73. Gupte R, Kadunganattil S, Shepherd A, Merrill R, Planer W, Bruchas M, et al. Convergent phosphomodulation of the major neuronal dendritic potassium channel Kv4.2 by pituitary adenylate cyclase-activating polypeptide. Neuropharmacology. 2016;101:291-308 pubmed publisher
    ..cloned and characterized the downstream signaling originating from the activation of three PACAP receptor (PAC1) isoforms that are expressed in rodent hippocampal neurons that also exhibit abundant expression of Kv4.2 protein...
  74. Yu R, Zheng L, Cui Y, Zhang H, Ye H. Doxycycline exerted neuroprotective activity by enhancing the activation of neuropeptide GPCR PAC1. Neuropharmacology. 2016;103:1-15 pubmed publisher
    ..pituitary adenylate cyclase-activating polypeptide (PACAP) preferring G protein-coupled receptor (GPCR), PACAP receptor 1(PAC1) and induced the internalization of PAC1 tagged with yellow fluorescent protein (YFP) indicating ..
  75. Brabet P, Diriong S, Journot L, Bockaert J, Taviaux S. Localization of the human pituitary adenylate cyclase-activating polypeptide receptor (PACAP1-R) gene to 7p15-p14 by fluorescence in situ hybridization. Genomics. 1996;38:100-2 pubmed
  76. Busto R, Prieto J, Bodega G, Zapatero J, Carrero I. Immunohistochemical localization and distribution of VIP/PACAP receptors in human lung. Peptides. 2000;21:265-9 pubmed
    ..The results agree with previous evidence on the importance of both peptides in the immune system and support their anti-inflammatory and protective roles in lung. ..
  77. Kellogg D, Zhao J, Wu Y, Johnson J. VIP/PACAP receptor mediation of cutaneous active vasodilation during heat stress in humans. J Appl Physiol (1985). 2010;109:95-100 pubmed publisher
    ..act through several receptor types: VIP through VPAC1 and VPAC2 receptors and PACAP through VPAC1, VPAC2, and PAC1 receptors...
  78. Jovanovic T, Norrholm S, Davis J, Mercer K, Almli L, Nelson A, et al. PAC1 receptor (ADCYAP1R1) genotype is associated with dark-enhanced startle in children. Mol Psychiatry. 2013;18:742-3 pubmed publisher
  79. Agnese M, Valiante S, Rosati L, Andreuccetti P, Prisco M. Pituitary adenylate cyclase-activating peptide (PACAP) and PAC1 receptor in the testis of cartilaginous fish Torpedo marmorata: A molecular and phylogenetic study. Comp Biochem Physiol B Biochem Mol Biol. 2016;191:26-35 pubmed publisher
    ..In this paper we investigated the sequence, expression and localization of PACAP and its PAC1 receptor in the testis of the benthic elasmobranch Torpedo marmorata, the marbled electric ray...
  80. Bardosi S, Bardosi A, Nagy Z, Reglodi D. Expression of PACAP and PAC1 Receptor in Normal Human Thyroid Gland and in Thyroid Papillary Carcinoma. J Mol Neurosci. 2016;60:171-8 pubmed publisher
    ..of PACAP expression has been shown in several tumors, but changes in expression of PACAP and its specific PAC1 receptor in human thyroid gland pathologies have not yet been investigated...
  81. Ma Y, Zhao S, Wang X, Shen S, Ma M, Xu W, et al. A New Recombinant PACAP-Derived Peptide Efficiently Promotes Corneal Wound Repairing and Lacrimal Secretion. Invest Ophthalmol Vis Sci. 2015;56:4336-49 pubmed publisher
    ..pituitary adenylate cyclase-activating polypeptide (PACAP)-derived peptide, MPAPO, which has higher stability and PAC1-specific potency, was generated...
  82. Jozwiak Bebenista M, Kowalczyk E. Neuroleptic Drugs and PACAP Differentially Affect the mRNA Expression of Genes Encoding PAC1/VPAC Type Receptors. Neurochem Res. 2017;42:943-952 pubmed publisher
    ..PCR) was used to examine the effects of haloperidol, olanzapine and amisulpride on the expression of genes coding PAC1/VPAC type receptors in the T98G glioblastoma cell line, as an example of an in vitro model of glial cells...
  83. Bourgault S, Vaudry D, Botia B, Couvineau A, Laburthe M, Vaudry H, et al. Novel stable PACAP analogs with potent activity towards the PAC1 receptor. Peptides. 2008;29:919-32 pubmed publisher
    ..In this study, derivatives of PACAP27 and PACAP38 have been rationally designed to develop PAC1 receptor agonists resistant to peptidase action...
  84. Miura A, Odahara N, Tominaga A, Inoue K, Kambe Y, Kurihara T, et al. Regulatory mechanism of PAC1 gene expression via Sp1 by nerve growth factor in PC12 cells. FEBS Lett. 2012;586:1731-5 pubmed publisher
    In addition to VPAC1 and VPAC2, PAC1 is involved in the pleiotropic action of pituitary adenylate cyclase activating polypeptide (PACAP) in the CNS...
  85. May V, Buttolph T, Girard B, Clason T, Parsons R. PACAP-induced ERK activation in HEK cells expressing PAC1 receptors involves both receptor internalization and PKC signaling. Am J Physiol Cell Physiol. 2014;306:C1068-79 pubmed publisher
    The pituitary adenylate cyclase-activating polypeptide (PACAP)-selective PAC1 receptor (Adcyap1r1) is a G protein-coupled receptor (GPCR) that activates adenylyl cyclase and PLC...
  86. Yin Y, de Waal P, He Y, Zhao L, Yang D, Cai X, et al. Rearrangement of a polar core provides a conserved mechanism for constitutive activation of class B G protein-coupled receptors. J Biol Chem. 2017;292:9865-9881 pubmed publisher
    ..Importantly, mutations in the corresponding polar core of several other members of class B GPCRs, including PTH1R, PAC1R, VIP1R, and CRFR1, also induce constitutive G protein signaling, suggesting that the rearrangement of the polar ..
  87. Solano R, Carmena M, Carrero I, Cavallaro S, Roman F, Hueso C, et al. Characterization of vasoactive intestinal peptide/pituitary adenylate cyclase-activating peptide receptors in human benign hyperplastic prostate. Endocrinology. 1996;137:2815-22 pubmed
  88. Mammi C, Frajese G, Vespasiani G, Mariani S, Gnessi L, Farini D, et al. PAC1-R null isoform expression in human prostate cancer tissue. Prostate. 2006;66:514-21 pubmed
    ..Our data demonstrates that the PAC(1)-R null variant is the most relevant isoform expressed in human PCa tissue being suggestively related with the events determining the outcome of prostate cancer. ..
  89. Le S, Yamaguchi D, McArdle C, Tachiki K, Pisegna J, Germano P. PAC1 and PACAP expression, signaling, and effect on the growth of HCT8, human colonic tumor cells. Regul Pept. 2002;109:115-25 pubmed
    The pituitary adenylate cyclase-activating polypeptide (PACAP) type 1 receptor (PAC1) is a heptahelical, G protein-coupled receptor that has been shown to be expressed by non-squamous lung cancer and breast cancer cell lines, and to be ..
  90. Germano P, Le S, Oh D, Fan R, Lieu S, Siu A, et al. Differential coupling of the PAC1 SV1 splice variant on human colonic tumors to the activation of intracellular cAMP but not intracellular Ca2+ does not activate tumor proliferation. J Mol Neurosci. 2004;22:83-92 pubmed
    b>PAC1 is a recently cloned and characterized heptahelical, G protein-coupled receptor with high affinity to PACAP-27 and PACAP-38 and is differentially coupled to activate intracellular Ca2+ and cAMP...
  91. Csanaky K, Banki E, Szabadfi K, Reglodi D, Tarcai I, Czegledi L, et al. Changes in PACAP immunoreactivity in human milk and presence of PAC1 receptor in mammary gland during lactation. J Mol Neurosci. 2012;48:631-7 pubmed
    ..However, it is not known how PACAP levels and the expression of PAC1 receptor change during lactation...
  92. Ressler K, Mercer K, Bradley B, Jovanovic T, Mahan A, Kerley K, et al. Post-traumatic stress disorder is associated with PACAP and the PAC1 receptor. Nature. 2011;470:492-7 pubmed publisher
    ..examined 44 single nucleotide polymorphisms (SNPs) spanning the PACAP (encoded by ADCYAP1) and PAC1 (encoded by ADCYAP1R1) genes, demonstrating a sex-specific association with PTSD...