Gene Symbol: ADCY9
Description: adenylate cyclase 9
Alias: AC9, ACIX, adenylate cyclase type 9, ATP pyrophosphate-lyase 9, adenylate cyclase type IX, adenylyl cyclase 9, type IX ATP pyrophosphate-lyase
Species: human
Products:     ADCY9

Top Publications

  1. Getz R, Kwak G, Cornell S, Mbugua S, Eberhard J, Huang S, et al. A fission yeast platform for heterologous expression of mammalian adenylyl cyclases and high throughput screening. Cell Signal. 2019;: pubmed publisher
    ..from all ten AC genes as well as GNAS-stimulated activity from eight of the nine transmembrane ACs (tmACs; AC2-AC9)...
  2. Qi C, Sorrentino S, Medalia O, Korkhov V. The structure of a membrane adenylyl cyclase bound to an activated stimulatory G protein. Science. 2019;364:389-394 pubmed publisher
    ..Here, we describe the cryo-electron microscopy structure of the bovine membrane AC9 bound to an activated G protein αs subunit at 3.4-angstrom resolution...
  3. Liu J, Jian T, Yue C, Chen D, Chen W, Bao T, et al. Chemo-resistant Gastric Cancer Associated Gene Expression Signature: Bioinformatics Analysis Based on Gene Expression Omnibus. Anticancer Res. 2019;39:1689-1698 pubmed publisher
    ..In the PPI network, the top ten hub genes ranked by degree were GNG7, PLCB1, CALML5, FGFR4, GRB2, JAK3, ADCY7, ADCY9, GNAS and KDR...
  4. Rosalind Lai P, Du R. Differentially expressed genes associated with the estrogen receptor pathway in cerebral aneurysms. World Neurosurg. 2019;: pubmed publisher
    ..41, false discovery rate [FDR]=6.1x10-5; ADCY9, FC=0.55, FDR=2.3x10-4), and two were up-regulated (HBEGF FC=1.46, FDR=4.9x10-4; ADCY7 FC=2...
  5. Wang T, Li B, Wang Z, Wang X, Xia Z, Ning G, et al. Sorafenib promotes sensory conduction function recovery via miR-142-3p/AC9/cAMP axis post dorsal column injury. Neuropharmacology. 2019;148:347-357 pubmed publisher
    ..Subsequently, the expression of adenylate cyclase 9 (AC9), the target gene of miR-142-3p, declined sharply in the SDCL group and declined limitedly in the SNCI group...
  6. Simpson J, Pálvölgyi A, Antoni F. Direct stimulation of adenylyl cyclase 9 by the fungicide imidazole miconazole. Naunyn Schmiedebergs Arch Pharmacol. 2019;392:497-504 pubmed publisher
    ..In crude membranes, the activity of AC9 in the presence of GDP-β-S was enhanced by miconazole with an EC50 of ~ 8 μM, while AC1 and AC2 ..
  7. Baldwin T, Li Y, Brand C, Watts V, Dessauer C. Insights into the Regulatory Properties of Human Adenylyl Cyclase Type 9. Mol Pharmacol. 2019;95:349-360 pubmed publisher
    ..Although insight into the physiologic relevance of AC9 has progressed, the understanding of AC9 regulation is muddled with conflicting studies...
  8. Orchel J, Witek L, Kimsa M, Strzalka Mrozik B, Kimsa M, Olejek A, et al. Expression patterns of kinin-dependent genes in endometrial cancer. Int J Gynecol Cancer. 2012;22:937-44 pubmed publisher
    ..Significant differential gene expression was recorded for GNB1, PRKAR1A, KRAS, MAP2K2, GNG5, MAPK1, ADCY9, GNG11, JUN, PRKCA, PRKACB, FOS, PLCB4, ADCY8, and GNG12...
  9. Zhu H, Lu S, Wei M, Cai X, Wang G. Identification of novel genes involved in gingival epithelial cells responding to Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis infections. Arch Oral Biol. 2018;96:113-121 pubmed publisher
    ..The up-regulated genes, including IL6, CCL19, EDN1, ADCY9, and BCL2 and the down-regulated genes, including CCNB1, PLK1, and CCNA2 were the key genes in the protein-protein ..

More Information


  1. Alles J, Hasler D, Kazmi S, Tesson M, Hamilton A, Schlegel L, et al. Epstein-Barr Virus EBER Transcripts Affect miRNA-Mediated Regulation of Specific Targets and Are Processed to Small RNA Species. Noncoding RNA. 2015;1:170-191 pubmed publisher
    ..However, the EBERs have no effect upon another target of miR-142-3p, ADCY9, nor on TOMM22, a target of ebv-miR-BART16, indicative of selective modulation of gene expression by the EBERs.
  2. Choudhary B, Mandelkow E, Mandelkow E, Pir G. Glutamatergic nervous system degeneration in a C. elegans TauA152T tauopathy model involves pathways of excitotoxicity and Ca2+ dysregulation. Neurobiol Dis. 2018;117:189-202 pubmed publisher
    ..The neuronal loss is caused by several determinants, such as altered adenylyl cyclase (type AC9) pathway, prevalence of excitotoxicity-like conditions, aging-related factors and finally dyshomeostasis of ..
  3. Alam M, Juraimi A, Rafii M, Hamid A, Arolu I, Abdul Latif M. Genetic diversity analysis among collected purslane (Portulaca oleracea L.) accessions using ISSR markers. C R Biol. 2015;338:1-11 pubmed publisher
    ..that are far from each other by virtue of genetic origin and diversity index (like Ac1 and Ac42; Ac19 and Ac45; Ac9 and Ac23; Ac18 and A25; Ac24 and Ac18) are strongly recommended to select as parent for future breeding program to ..
  4. Weng J, Wu L, Lee C, Hsu P, Cheng A. Integrative epigenetic profiling analysis identifies DNA methylation changes associated with chronic alcohol consumption. Comput Biol Med. 2015;64:299-306 pubmed publisher
    ..include genes involved in neurogenesis (NPDC1) and inflammation (HERC5), as well as alcoholism-associated genes ADCY9, CKM, and PHOX2A...
  5. Castilho A, Nogueira M, Fontes P, Machado M, Satrapa R, Razza E, et al. Ovarian superstimulation using FSH combined with equine chorionic gonadotropin (eCG) upregulates mRNA-encoding proteins involved with LH receptor intracellular signaling in granulosa cells from Nelore cows. Theriogenology. 2014;82:1199-205 pubmed publisher
    ..abundance of GNAS, GNAQ, GNA11, PLCB1, PLCB, PLCB4, and adenylyl cyclase isoforms (ADCY3, ADCY4, ADCY6, ADCY8, and ADCY9) was measured by real-time reserve transcription followed by polymerase chain reaction...
  6. Pálvölgyi A, Simpson J, Bodnar I, Biro J, Palkovits M, Radovits T, et al. Auto-inhibition of adenylyl cyclase 9 (AC9) by an isoform-specific motif in the carboxyl-terminal region. Cell Signal. 2018;51:266-275 pubmed publisher
    ..b>AC9 is highly expressed in vital organs such as the heart and the brain...
  7. Liu L, Das S, Losert W, Parent C. mTORC2 regulates neutrophil chemotaxis in a cAMP- and RhoA-dependent fashion. Dev Cell. 2010;19:845-57 pubmed publisher
    ..the ability of chemoattractants to induce cAMP production, a process mediated through the activation of the adenylyl cyclase 9 (AC9)...
  8. Apinjoh T, Anchang Kimbi J, Njua Yafi C, Ngwai A, Mugri R, Clark T, et al. Association of candidate gene polymorphisms and TGF-beta/IL-10 levels with malaria in three regions of Cameroon: a case-control study. Malar J. 2014;13:236 pubmed publisher
    ..Furthermore, ADCY9 rs10775349 (additive G) and ABO rs8176746 AC individuals were associated with protection from hyperpyrexia and ..
  9. Rautureau Y, Deschambault V, Higgins M, Rivas D, Mecteau M, Geoffroy P, et al. Adenylate Cyclase Type 9 (ADCY9) Inactivation Protects from Atherosclerosis Only in the Absence of Cholesteryl Ester Transfer Protein (CETP). Circulation. 2018;: pubmed publisher
    b>Background -Pharmacogenomic studies have shown that ADCY9 genotype determines the effects of the cholesteryl ester transfer protein (CETP) inhibitor dalcetrapib on cardiovascular events and atherosclerosis imaging...
  10. Calebiro D, Grassi E, Eszlinger M, Ronchi C, Godbole A, Bathon K, et al. Recurrent EZH1 mutations are a second hit in autonomous thyroid adenomas. J Clin Invest. 2016;126:3383-8 pubmed publisher
    ..EZH1 mutations were strongly associated with known (TSHR, GNAS) or presumed (adenylate cyclase 9 [ADCY9]) alterations in cAMP pathway genes. Furthermore, functional studies revealed that the p...
  11. Crujeiras A, Díaz Lagares A, Moreno Navarrete J, Sandoval J, Hervas D, Gomez A, et al. Genome-wide DNA methylation pattern in visceral adipose tissue differentiates insulin-resistant from insulin-sensitive obese subjects. Transl Res. 2016;178:13-24.e5 pubmed publisher
    ..genes epigenetically regulated in VAT, such as COL9A1, COL11A2, CD44, MUC4, ADAM2, IGF2BP1, GATA4, TET1, ZNF714, ADCY9, TBX5, and HDACM...
  12. Verardo L, Sevón Aimonen M, Serenius T, Hietakangas V, Uimari P. Whole-genome association analysis of pork meat pH revealed three significant regions and several potential genes in Finnish Yorkshire pigs. BMC Genet. 2017;18:13 pubmed publisher
    ..The significant regions harbored several genes, including two genes involved in cyclic AMP (cAMP) signaling: ADCY9 and CREBBP...
  13. Alam M, Juraimi A, Rafii M, Hamid A, Aslani F, Hakim M. Salinity-induced changes in the morphology and major mineral nutrient composition of purslane (Portulaca oleracea L.) accessions. Biol Res. 2016;49:24 pubmed publisher
    ..respectively, at 32 dS m(-1) salinity, whereas the highest increase in both fresh and dry weight was recorded in Ac9 at 24 dS m(-1) salinity compared to the control...
  14. Manjurano A, Clark T, Nadjm B, Mtove G, Wangai H, Sepúlveda N, et al. Candidate human genetic polymorphisms and severe malaria in a Tanzanian population. PLoS ONE. 2012;7:e47463 pubmed publisher
    ..A SNP in the adenyl cyclase 9 (ADCY9) gene was associated with protection from acidosis whilst a polymorphism in the IL-1α gene (IL1A) was ..
  15. Tardif J, Rhainds D, Rhéaume E, Dube M. CETP: Pharmacogenomics-Based Response to the CETP Inhibitor Dalcetrapib. Arterioscler Thromb Vasc Biol. 2017;37:396-400 pubmed publisher
    ..demonstrated in the dal-OUTCOMES trial to be influenced by correlated polymorphisms in the ADCY9 (adenylate cyclase type 9) gene (P=2.4×10-8 for rs1967309)...
  16. Niesor E, Benghozi R, Amouyel P, Ferdinand K, Schwartz G. Adenylyl Cyclase 9 Polymorphisms Reveal Potential Link to HDL Function and Cardiovascular Events in Multiple Pathologies: Potential Implications in Sickle Cell Disease. Cardiovasc Drugs Ther. 2015;29:563-572 pubmed publisher
    b>Adenylyl cyclase 9 (ADCY9) mediates β2-adrenoceptor (β2-AR) signalling. Both proteins are associated with caveolae, specialized cholesterol-rich membrane substructures...
  17. Stone M, Sharma A, Mas V, Gehrau R, Mulloy D, Zhao Y, et al. Ex Vivo Perfusion With Adenosine A2A Receptor Agonist Enhances Rehabilitation of Murine Donor Lungs After Circulatory Death. Transplantation. 2015;99:2494-503 pubmed publisher
    ..uniquely regulated by EVLP + ATL1223 including the downregulation of genes involved in IL-1 signaling, such as ADCY9, ECSIT, IRAK1, MAPK12, and TOLLIP...
  18. Schwickert A, Weghake E, Brüggemann K, Engbers A, Brinkmann B, Kemper B, et al. microRNA miR-142-3p Inhibits Breast Cancer Cell Invasiveness by Synchronous Targeting of WASL, Integrin Alpha V, and Additional Cytoskeletal Elements. PLoS ONE. 2015;10:e0143993 pubmed publisher
    ..ROCK2, IL6ST, KLF4, PGRMC2 and ADCY9 were identified as additional targets in a subset of cell lines...
  19. Li Y, Baldwin T, Wang Y, Subramaniam J, Carbajal A, Brand C, et al. Loss of type 9 adenylyl cyclase triggers reduced phosphorylation of Hsp20 and diastolic dysfunction. Sci Rep. 2017;7:5522 pubmed publisher
    Adenylyl cyclase type 9 (AC9) is found tightly associated with the scaffolding protein Yotiao and the IKs ion channel in heart. But apart from potential IKs regulation, physiological roles for AC9 are unknown...
  20. Maiga B, Dolo A, Toure O, Dara V, Tapily A, Campino S, et al. Human candidate polymorphisms in sympatric ethnic groups differing in malaria susceptibility in Mali. PLoS ONE. 2013;8:e75675 pubmed publisher
    ..We identified SNP allele frequency differences between the 2 ethnic groups in CD36, IL4, RTN3 and ADCY9. Moreover, polymorphisms in FCER1A, RAD50, TNF, SLC22A4, and IL13 genes were correlated with antibody production (..
  21. Briceno G, Schalchli H, Rubilar O, Tortella G, Mutis A, Benimeli C, et al. Increased diazinon hydrolysis to 2-isopropyl-6-methyl-4-pyrimidinol in liquid medium by a specific Streptomyces mixed culture. Chemosphere. 2016;156:195-203 pubmed publisher
    ..strains AC5, AC9, GA11 and ISP13 were mixed; this was defined as the selected mixed culture (SMC)...
  22. Tan X, Banerjee P, Liu X, Yu J, Gibbons D, Wu P, et al. The epithelial-to-mesenchymal transition activator ZEB1 initiates a prometastatic competing endogenous RNA network. J Clin Invest. 2018;128:1267-1282 pubmed publisher
    ..ZEB1 relieved a strong basal repression of ?1 integrin (ITGA1) mRNA, which in turn upregulated adenylyl cyclase 9 mRNA (ADCY9) by sponging miR181b...
  23. Su Y, Li J, Dai W, Liao X, Dong L, Lu T, et al. Genetic variation in the tryptophan hydroxylase 2 gene moderates depressive symptom trajectories and remission over 8 weeks of escitalopram treatment. Int Clin Psychopharmacol. 2016;31:127-33 pubmed publisher
    ..of this study was to investigate the relationship between genotypic variation in six candidate serotonergic genes (ADCY9, HTR1B, GNB3, HTR2A, TPH2, SLC6A4) and depressive and anxiety symptom severity trajectories as well as remission ..
  24. Baburski A, Sokanovic S, Andric S, Kostic T. Aging has the opposite effect on cAMP and cGMP circadian variations in rat Leydig cells. J Comp Physiol B. 2017;187:613-623 pubmed publisher
    ..associated with changed expression of genes involved in cAMP production (increased circadian pattern of Adcy7, Adcy9, Adcy10 and decreased Adcy3); cAMP degradation (increased Pde4a, decreased Pde8b, canceled rhythm of Pde4d, ..
  25. Auburn S, Fry A, Clark T, Campino S, Diakite M, Green A, et al. Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis. PLoS ONE. 2010;5:e10017 pubmed publisher
    ..genes: adenosine receptor 2A (ADORA2A) and 2B (ADORA2B), beta-adrenergic receptor kinase 1 (ADRBK1), adenylyl cyclase 9 (ADCY9), G protein beta subunit 3 (GNB3), and regulator of G protein signalling 2 (RGS2)...
  26. Berndt S, Gustafsson S, Magi R, Ganna A, Wheeler E, Feitosa M, et al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. Nat Genet. 2013;45:501-12 pubmed publisher
    ..and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity...
  27. Tardif J, Rhéaume E, Lemieux Perreault L, Grégoire J, Feroz Zada Y, Asselin G, et al. Pharmacogenomic determinants of the cardiovascular effects of dalcetrapib. Circ Cardiovasc Genet. 2015;8:372-82 pubmed publisher
    ..polymorphism was found to be associated with cardiovascular events in the dalcetrapib arm, identifying the ADCY9 gene on chromosome 16 (rs1967309; P=2.41×10(-8)), with 8 polymorphisms providing P<10(-6) in this gene...
  28. Barcova M, Speth C, Kacani L, Uberall F, Stoiber H, Dierich M. Involvement of adenylate cyclase and p70(S6)-kinase activation in IL-10 up-regulation in human monocytes by gp41 envelope protein of human immunodeficiency virus type 1. Pflugers Arch. 1999;437:538-46 pubmed
  29. Patke C, Shearer W. gp120- and TNF-alpha-induced modulation of human B cell function: proliferation, cyclic AMP generation, Ig production, and B-cell receptor expression. J Allergy Clin Immunol. 2000;105:975-82 pubmed
    ..gp120 modulation of TNF-alpha-induced B-cell receptor- and cAMP-mediated signal transduction events may be involved in the B-cell abnormalities observed in HIV-1 infection. ..
  30. Taylor S, Buechler J, Yonemoto W. cAMP-dependent protein kinase: framework for a diverse family of regulatory enzymes. Annu Rev Biochem. 1990;59:971-1005 pubmed
  31. Risøe P, Rutkovskiy A, Ågren J, Kolseth I, Kjeldsen S, Valen G, et al. Higher TNFα responses in young males compared to females are associated with attenuation of monocyte adenylyl cyclase expression. Hum Immunol. 2015;76:427-30 pubmed publisher
    ..Rapid down-regulation of the monocyte AC isoforms AC4, AC7 and AC9 were observed in young males...
  32. Li Y, Chen L, Kass R, Dessauer C. The A-kinase anchoring protein Yotiao facilitates complex formation between adenylyl cyclase type 9 and the IKs potassium channel in heart. J Biol Chem. 2012;287:29815-24 pubmed publisher
    ..previously identified a subset of adenylyl cyclase (AC) isoforms that interact with Yotiao, including AC1-3 and AC9, but surprisingly, this group did not include the major cardiac isoforms AC5 and AC6...
  33. Eid N, Hussein A, Elzein A, Mohamed H, Rockett K, Kwiatkowski D, et al. Candidate malaria susceptibility/protective SNPs in hospital and population-based studies: the effect of sub-structuring. Malar J. 2010;9:119 pubmed publisher
  34. Ye Y, Lee H, Kim S, Jee Y, Lee S, Lee S, et al. Pharmacogenetic study of the effects of NK2R G231E G>A and TBX21 H33Q C>G polymorphisms on asthma control with inhaled corticosteroid treatment. J Clin Pharm Ther. 2009;34:693-701 pubmed publisher
    ..genotyped for four genetic polymorphisms of four genes: beta2-adrenergic receptor (ADRB2), adenylate cyclase 9 (ADCY9), neurokinin receptor 2 (NK2R) and T-box 21 (TBX21)...
  35. Ludwig M, Seuwen K. Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. J Recept Signal Transduct Res. 2002;22:79-110 pubmed
    ..We found that human AC genes comprise 11 to 26 exons, which are distributed over 16 to 430kb. We further report expression profiles for the nine ACs in a panel of 16 human tissues and in human embryonic kidney (HEK) cells. ..
  36. Yang L, Wang Y, Liu S, Zhang P, Chen Z, Liu M, et al. miR-181b promotes cell proliferation and reduces apoptosis by repressing the expression of adenylyl cyclase 9 (AC9) in cervical cancer cells. FEBS Lett. 2014;588:124-30 pubmed publisher
    ..And we validated a new miR-181b target gene, adenylyl cyclase 9 (AC9). miR-181b restricted cAMP production by post-transcriptionally downregulating AC9 expression...
  37. Kittikulsuth W, Friedman P, Van Hoek A, Gao Y, Kohan D. Identification of adenylyl cyclase isoforms mediating parathyroid hormone- and calcitonin-stimulated cyclic AMP accumulation in distal tubule cells. BMC Nephrol. 2017;18:292 pubmed publisher
    ..Both cell types expressed AC3, AC4, AC6, AC7, and AC9 mRNA; in both cell types, AC6 mRNA was most abundant, followed by AC9, then AC3 and AC7, with relatively very small ..
  38. Choi L, Jenikova G, Hanson E, Spehlmann M, Boehling N, Kirstein S, et al. Coordinate down-regulation of adenylyl cyclase isoforms and the stimulatory G protein (G(s)) in intestinal epithelial cell differentiation. J Biol Chem. 2010;285:12504-11 pubmed publisher
    ..By contrast, AC1, AC2, AC8, and AC9, and the receptors for prostaglandin E(2) and vasoactive intestinal polypeptide, are not expressed or not affected ..
  39. Paterson J, Smith S, Simpson J, Grace O, Sosunov A, Bell J, et al. Characterisation of human adenylyl cyclase IX reveals inhibition by Ca(2+)/Calcineurin and differential mRNA plyadenylation. J Neurochem. 2000;75:1358-67 pubmed
    ..This study reports the cloning and functional characterisation of a cDNA encoding human adenylyl cyclase IX (ACIX)...
  40. Liu D, Wang H, Schwender H, Marazita M, Wang Z, Yuan Y, et al. Gene-gene interaction of single nucleotide polymorphisms in 16p13.3 may contribute to the risk of non-syndromic cleft lip with or without cleft palate in Chinese case-parent trios. Am J Med Genet A. 2017;173:1489-1494 pubmed publisher
    ..after Bonferroni correction, among which the most significant interaction was found between rs2072346 (ADCY9) and rs11646137 (intergenic region, P?=?7.2?×?10-5 )...
  41. Kleuss C, Raw A, Lee E, Sprang S, Gilman A. Mechanism of GTP hydrolysis by G-protein alpha subunits. Proc Natl Acad Sci U S A. 1994;91:9828-31 pubmed
  42. Zhuang L, Xu G, Pan X, Lou Y, Zou Q, Xia D, et al. MicroRNA-181a-mediated downregulation of AC9 protein decreases intracellular cAMP level and inhibits ATRA-induced APL cell differentiation. Cell Death Dis. 2014;5:e1161 pubmed publisher
    b>AC9 is one of the adenylate cyclase (AC) isoforms, which catalyze the conversion of ATP to cAMP, an important second messenger...
  43. Kasperaviciute D, Catarino C, Heinzen E, Depondt C, Cavalleri G, Caboclo L, et al. Common genetic variation and susceptibility to partial epilepsies: a genome-wide association study. Brain. 2010;133:2136-47 pubmed publisher
    ..Data emerging from genome-wide association-studies will be valuable during the next serious challenge of interpreting all the genetic variation emerging from whole-genome sequencing studies. ..
  44. Tesmer J, Sunahara R, Gilman A, Sprang S. Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science. 1997;278:1907-16 pubmed
    ..On the basis of these and other structures, a molecular mechanism is proposed for the activation of adenylyl cyclase by Gsalpha. ..
  45. Qualls Creekmore E, Gupta R, Yoshimura M. The effect of alcohol on recombinant proteins derived from mammalian adenylyl cyclase. Biochem Biophys Rep. 2017;10:157-164 pubmed publisher
    ..AC recombinant proteins containing only the C1a or C2 domains of AC7 and AC9 individually were expressed in bacteria, and purified...
  46. Small K, Brown K, Theiss C, Seman C, Weiss S, Liggett S. An Ile to Met polymorphism in the catalytic domain of adenylyl cyclase type 9 confers reduced beta2-adrenergic receptor stimulation. Pharmacogenetics. 2003;13:535-41 pubmed
    ..we characterize the population genomics and signalling effects of a polymorphism within the coding region of the AC9 gene that results in an Ile to Met substitution at amino acid 772 within the C1b region of the enzyme...
  47. Sunahara R, Taussig R. Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Mol Interv. 2002;2:168-84 pubmed
  48. Niesor E, Benghozi R. Potential Signal Transduction Regulation by HDL of the β2-Adrenergic Receptor Pathway. Implications in Selected Pathological Situations. Arch Med Res. 2015;46:361-71 pubmed publisher
    ..This potential was recently highlighted following the identification of a polymorphism in the adenylyl cyclase 9 gene (ADCY9) that was shown to be a determining factor in the risk of cardiovascular (CV) events in patients ..
  49. Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Wurzner R, Stoiber H, et al. Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons. J Virol. 2002;76:3179-88 pubmed
    ..This strengthens the hypothesis that HIV-induced complement synthesis represents an important mechanism for the pathogenesis of AIDS in the brain. ..
  50. Hacker B, Tomlinson J, Wayman G, Sultana R, Chan G, Villacres E, et al. Cloning, chromosomal mapping, and regulatory properties of the human type 9 adenylyl cyclase (ADCY9). Genomics. 1998;50:97-104 pubmed
    ..Here we report the cloning, chromosomal mapping, and regulatory properties of human AC9 (HGMW-approved symbol ADCY9)...
  51. Toyota T, Yamada K, Saito K, Detera Wadleigh S, Yoshikawa T. Association analysis of adenylate cyclase type 9 gene using pedigree disequilibrium test in bipolar disorder. Mol Psychiatry. 2002;7:450-2 pubmed
  52. Patrizio M, Colucci M, Levi G. Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. J Neurochem. 2001;77:399-407 pubmed
  53. Tantisira K, Small K, Litonjua A, Weiss S, Liggett S. Molecular properties and pharmacogenetics of a polymorphism of adenylyl cyclase type 9 in asthma: interaction between beta-agonist and corticosteroid pathways. Hum Mol Genet. 2005;14:1671-7 pubmed
    ..One effector for airway beta2AR, adenylyl cyclase type 9 (AC9), was considered a candidate locus for predicting beta-agonist efficacy in the absence and presence of ..
  54. Wojcik C, Volz K, Ranola M, Kitch K, Karim T, O Neil J, et al. Rubinstein-Taybi syndrome associated with Chiari type I malformation caused by a large 16p13.3 microdeletion: a contiguous gene syndrome?. Am J Med Genet A. 2010;152A:479-83 pubmed publisher
    ..CGH microarray showed a approximately 520.7 kb microdeletion on 16p13.3 involving CREBBP, ADCY9, and SRL genes...
  55. Juszczak G, Stankiewicz A. Glucocorticoids, genes and brain function. Prog Neuropsychopharmacol Biol Psychiatry. 2018;82:136-168 pubmed publisher
    ..and Il6r), signaling mediated by thyroid hormones (Thra and Sult1a1), calcium (Calm2), adrenaline/noradrenaline (Adcy9 and Adra1d), neuropeptide Y (Npy1r) and histamine (Hdc)...
  56. Toyota T, Hattori E, Meerabux J, Yamada K, Saito K, Shibuya H, et al. Molecular analysis, mutation screening, and association study of adenylate cyclase type 9 gene (ADCY9) in mood disorders. Am J Med Genet. 2002;114:84-92 pubmed
    ..An interesting candidate gene in this region is the adenylate cyclase (AC) type 9 gene (ADCY9)...
  57. Cumbay M, Watts V. Novel regulatory properties of human type 9 adenylate cyclase. J Pharmacol Exp Ther. 2004;310:108-15 pubmed
    ..The least characterized and most divergent in sequence of the nine adenylate cyclase isoforms is AC9. Stimulation by Galpha(s) and inhibition by Ca2+/calcineurin are two modes of regulation that have been reported ..
  58. Speth C, Joebstl B, Barcova M, Dierich M. HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. AIDS. 2000;14:629-36 pubmed
    ..Expression of the chemokine receptor CXCR4 was only slightly altered. These findings suggest a role for gp41 in the modulation of brain-specific host defence, cell migration and cell infectivity by HIV. ..
  59. Dessauer C, Gilman A. Purification and characterization of a soluble form of mammalian adenylyl cyclase. J Biol Chem. 1996;271:16967-74 pubmed
    ..After adenovirus-mediated expression in adenylyl cyclase-deficient HC-1 cells, the enzyme can be stimulated synergistically by Gs-coupled receptors and forskolin. ..
  60. Premont R, Matsuoka I, Mattei M, Pouille Y, Defer N, Hanoune J. Identification and characterization of a widely expressed form of adenylyl cyclase. J Biol Chem. 1996;271:13900-7 pubmed
    ..The AC9 gene has been localized to human chromosome band 16p13.3-13.2. The 8...
  61. Teixeira H, Alcantara Neves N, Barreto M, Figueiredo C, Costa R. Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children. Mol Immunol. 2017;82:137-145 pubmed publisher
    ..The gene adenylyl cyclase type 9 (ADCY9) encodes a protein called adenylyl cyclase (AC), responsible for producing the second messenger cyclic AMP (cAMP)...