ADCY5

Summary

Gene Symbol: ADCY5
Description: adenylate cyclase 5
Alias: AC5, FDFM, adenylate cyclase type 5, ATP pyrophosphate-lyase 5, adenylate cyclase type V, adenylyl cyclase 5
Species: human
Products:     ADCY5

Top Publications

  1. Ludwig M, Seuwen K. Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms. J Recept Signal Transduct Res. 2002;22:79-110 pubmed
    ..We found that human AC genes comprise 11 to 26 exons, which are distributed over 16 to 430kb. We further report expression profiles for the nine ACs in a panel of 16 human tissues and in human embryonic kidney (HEK) cells. ..
  2. Saxena R, Hivert M, Langenberg C, Tanaka T, Pankow J, Vollenweider P, et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nat Genet. 2010;42:142-8 pubmed publisher
    ..3 x 10(-16)) and diminished incretin effect (n = 804; P = 4.3 x 10(-4)). We also identified variants at ADCY5 (rs2877716, P = 4.2 x 10(-16)), VPS13C (rs17271305, P = 4.1 x 10(-8)), GCKR (rs1260326, P = 7...
  3. Freathy R, Mook Kanamori D, Sovio U, Prokopenko I, Timpson N, Berry D, et al. Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight. Nat Genet. 2010;42:430-5 pubmed publisher
    ..rs900400 near LEKR1 and CCNL1 (P = 2 x 10(-35)) and rs9883204 in ADCY5 (P = 7 x 10(-15)) were robustly associated with birth weight...
  4. Vasan S, Neville M, Antonisamy B, Samuel P, Fall C, Geethanjali F, et al. Absence of birth-weight lowering effect of ADCY5 and near CCNL, but association of impaired glucose-insulin homeostasis with ADCY5 in Asian Indians. PLoS ONE. 2011;6:e21331 pubmed publisher
    ..Recently, two birth weight-lowering loci on chromosome 3 (near CCNL1 and ADCY5) were identified in a genome-wide association study, the latter of which is also a type 2 diabetes locus...
  5. Windholz J, Kovacs P, Tonjes A, Dittrich K, Bluher S, Kiess W, et al. Effects of genetic variants in ADCY5, GIPR, GCKR and VPS13C on early impairment of glucose and insulin metabolism in children. PLoS ONE. 2011;6:e22101 pubmed publisher
    ..We investigated the role of four of these loci (ADCY5, GIPR, GCKR and VPS13C) in early impairment of glucose and insulin metabolism in children...
  6. Hodson D, Mitchell R, Marselli L, Pullen T, Gimeno Brias S, Semplici F, et al. ADCY5 couples glucose to insulin secretion in human islets. Diabetes. 2014;63:3009-21 pubmed publisher
    Single nucleotide polymorphisms (SNPs) within the ADCY5 gene, encoding adenylate cyclase 5, are associated with elevated fasting glucose and increased type 2 diabetes (T2D) risk...
  7. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson A, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010;42:105-16 pubmed publisher
    ..These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near ..
  8. Wagner R, Dudziak K, Herzberg Schäfer S, Machicao F, Stefan N, Staiger H, et al. Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin. PLoS ONE. 2011;6:e23639 pubmed publisher
    ..12 single nucleotide polymorphisms (SNP) in or near the genes GCK (rs4607517), DGKB (rs2191349), GCKR (rs780094), ADCY5 (rs11708067), MADD (rs7944584), ADRA2A (rs10885122), FADS1 (rs174550), CRY2 (rs11605924), SLC2A2 (rs11920090), ..
  9. Huopio H, Cederberg H, Vangipurapu J, Hakkarainen H, Pääkkönen M, Kuulasmaa T, et al. Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes. Eur J Endocrinol. 2013;169:291-7 pubmed publisher
    ..rs9939609 of FTO, rs2796441 of TLE1, rs560887 of G6PC2, rs780094 of GCKR, rs7903146 of TCF7L2 and rs11708067 of ADCY5 showed nominally significant associations with GDM (OR range from 1.25 to 1.30)...

More Information

Publications133 found, 100 shown here

  1. Sommese L, Benincasa G, Lanza M, Sorriento A, Schiano C, Lucchese R, et al. Novel epigenetic-sensitive clinical challenges both in type 1 and type 2 diabetes. J Diabetes Complications. 2018;: pubmed publisher
    ..Differentially methylated regions in pancreatic islets from type 2 diabetes covered PDX1, TCF7L2, and ADCY5 promoters during islet dysfunction...
  2. Zouvelou V, Yubero D, Apostolakopoulou L, Kokkinou E, Bilanakis M, Dalivigka Z, et al. The genetic etiology in cerebral palsy mimics: The results from a Greek tertiary care center. Eur J Paediatr Neurol. 2019;: pubmed publisher
    ..5 hereditary spastic paraplegia genes (SPG) in spastic CP mimics; HPRT1, TH, QDPR, DDC in dystonic CP mimics; ADCY5 and NIKX2-1 in choreic CP mimics; CANA1A in ataxic CP mimics; and SPG, PDHA1, NIKX2-1, AT, SLC2A1 and SPR in mixed ..
  3. Zhao Z, Babu G, Wen H, Fefelova N, Gordan R, Sui X, et al. Overexpression of adenylyl cyclase type 5 (AC5) confers a proarrhythmic substrate to the heart. Am J Physiol Heart Circ Physiol. 2015;308:H240-9 pubmed publisher
    ..Therefore, it is surprising that prior studies on overexpression of AC5 and AC6 in transgenic (Tg) mice have not examined mediation of arrhythmogenesis...
  4. Cai Z, Guldbrandtsen B, Lund M, Sahana G. Prioritizing candidate genes for fertility in dairy cows using gene-based analysis, functional annotation and differential gene expression. BMC Genomics. 2019;20:255 pubmed publisher
    ..In the candidate genes list, differentially expressed genes from different studies support FRAS1, ITGB5, ADCY5, and SEMA5B as candidate genes for cow fertility...
  5. Bohlega S, Abou Al Shaar H, Aldakheel A, Alajlan H, Bohlega B, Meyer B, et al. Autosomal recessive ADCY5-Related dystonia and myoclonus: Expanding the genetic spectrum of ADCY5-Related movement disorders. Parkinsonism Relat Disord. 2019;: pubmed publisher
    b>ADCY5-related hyperkinesia encompasses a heterogeneous group of phenotypes, including paroxysmal chorea, myoclonus, and dystonia. The disease is attributed to mutations of ADCY5, which encodes an adenylate cyclase enzyme...
  6. Cosson M, Hiis H, Moltzau L, Levy F, Krobert K. Knockout of adenylyl cyclase isoform 5 or 6 differentially modifies the β1-adrenoceptor-mediated inotropic response. J Mol Cell Cardiol. 2019;: pubmed publisher
    ..Subcellular localization of the AC5/6 subtypes varies contributing to the compartmentation of βAR signaling...
  7. Rosalind Lai P, Du R. Differentially expressed genes associated with the estrogen receptor pathway in cerebral aneurysms. World Neurosurg. 2019;: pubmed publisher
    ..46, FDR=6.3x10-5) and women (FC=0.46, FDR=2.3x10-4), while JUN, ADCY5 and MMP9 were significant in women only...
  8. Lai L, Yan L, Gao S, Hu C, Ge H, Davidow A, et al. Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway. Circulation. 2013;127:1692-701 pubmed publisher
    For reasons that remain unclear, whether type 5 adenylyl cyclase (AC5), 1 of 2 major AC isoforms in heart, is protective or deleterious in response to cardiac stress is controversial...
  9. Dy M, Chang F, Jesus S, Anselm I, Mahant N, Zeilman P, et al. Treatment of ADCY5-Associated Dystonia, Chorea, and Hyperkinetic Disorders With Deep Brain Stimulation: A Multicenter Case Series. J Child Neurol. 2016;31:1027-35 pubmed publisher
    b>ADCY5 mutations have been reported as a cause of early onset hyperkinetic movements associated with delayed motor milestones, hypotonia, and exacerbation during sleep...
  10. De Lorenzo M, Chen W, Baljinnyam E, Carlini M, La Perle K, Bishop S, et al. 'Reduced malignancy as a mechanism for longevity in mice with adenylyl cyclase type 5 disruption'. Aging Cell. 2014;13:102-10 pubmed publisher
    Disruption of adenylyl cyclase type 5 (AC5) knockout (KO) is a novel model for longevity...
  11. Baldwin T, Li Y, Brand C, Watts V, Dessauer C. Insights into the Regulatory Properties of Human Adenylyl Cyclase Type 9. Mol Pharmacol. 2019;95:349-360 pubmed publisher
    ..Importantly, although AC9 is not directly inhibited by Gαi/o, it can heterodimerize with Gαi/o-regulated isoforms, AC5 and AC6.
  12. Romero Calvo I, Ocón B, Gámez Belmonte R, Hernández Chirlaque C, de Jonge H, Bijvelds M, et al. Adenylyl cyclase 6 is involved in the hyposecretory status of experimental colitis. Pflugers Arch. 2018;470:1705-1717 pubmed publisher
    ..AC6 and AC5 were found to be expressed in colonocytes, and downregulated by inflammation, with the former exhibiting ..
  13. Vatner S, Park M, Yan L, Lee G, Lai L, Iwatsubo K, et al. Adenylyl cyclase type 5 in cardiac disease, metabolism, and aging. Am J Physiol Heart Circ Physiol. 2013;305:H1-8 pubmed publisher
    ..state are well known, this review will address our current understanding of the distinct regulatory role of the AC5 isoform in response to chronic stress...
  14. Machiela M, Lindstrom S, Allen N, Haiman C, Albanes D, Barricarte A, et al. Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium. Am J Epidemiol. 2012;176:1121-9 pubmed publisher
    ..Ten T2D markers near 9 loci (NOTCH2, ADCY5, JAZF1, CDKN2A/B, TCF7L2, KCNQ1, MTNR1B, FTO, and HNF1B) were nominally associated with PCa (P < 0...
  15. Zhang M, Ren Y, Wang Y, Wang R, Zhou Q, Peng Y, et al. Regulation of smooth muscle contractility by competing endogenous mRNAs in intracranial aneurysms. J Neuropathol Exp Neurol. 2015;74:411-24 pubmed publisher
    ..and experimental approach, we determined that depletion of competitive endogenous RNAs (ARHGEF12, FGF12, and ADCY5) enhanced factors that downregulate MYOCD, which induces the conversion of SMCs from differentiated contractile ..
  16. Yan L, Vatner S, Vatner D. Disruption of type 5 adenylyl cyclase prevents β-adrenergic receptor cardiomyopathy: a novel approach to β-adrenergic receptor blockade. Am J Physiol Heart Circ Physiol. 2014;307:H1521-8 pubmed publisher
    ..We hypothesized that disruption of type 5 adenylyl cyclase (AC5), which is in the β-AR signaling pathway in the heart, but exerts only a minor β-AR blocking effect, could ..
  17. Huttala O, Mysore R, Sarkanen J, Heinonen T, Olkkonen V, Ylikomi T. Differentiation of human adipose stromal cells in vitro into insulin-sensitive adipocytes. Cell Tissue Res. 2016;366:63-74 pubmed publisher
    ..adipocyte-specific gene expression (PPAR?, adiponectin, AP2, leptin, Glut4, Prdm16, CIDEA, PGC1-?, RIP140, UCP and ADCY5)...
  18. Vijiaratnam N, Newby R, Kempster P. Depression and psychosis in ADCY5-related dyskinesia-part of the phenotypic spectrum?. J Clin Neurosci. 2018;57:167-168 pubmed publisher
    This report details prominent neuropsychiatric features in one family with an ADCY5 gene mutation. ADCY5 mutations cause a variable motor phenotype, though most cases have some core involuntary movement features...
  19. Olsson A, Volkov P, Bacos K, Dayeh T, Hall E, Nilsson E, et al. Genome-wide associations between genetic and epigenetic variation influence mRNA expression and insulin secretion in human pancreatic islets. PLoS Genet. 2014;10:e1004735 pubmed publisher
    ..These include reported diabetes loci, e.g. ADCY5, KCNJ11, HLA-DQA1, INS, PDX1 and GRB10...
  20. Reddy G, Subramanian H, Birk A, Milde M, Nikolaev V, Bünemann M. Adenylyl cyclases 5 and 6 underlie PIP3-dependent regulation. FASEB J. 2015;29:3458-71 pubmed publisher
    ..a well-known rebound stimulation phenomenon after withdrawal of Gi protein in atrial myocytes, we discovered that AC5 and -6 are tightly regulated by the second messenger PIP3...
  21. Park H, Kang Y, Kang Y, Park T, Ryu Y, Hwang J, et al. Inhibition of adenylyl cyclase type 5 prevents L-DOPA-induced dyskinesia in an animal model of Parkinson's disease. J Neurosci. 2014;34:11744-53 pubmed publisher
    ..we prepared an animal model with unilateral 6-hydroxydopamine lesions in the substantia nigra in wild-type and AC5-knock-out (KO) mice, and examined behavioral responses to short-term or long-term treatment with L-DOPA...
  22. Mahavadi S, Nalli A, Kumar D, Hu W, Kuemmerle J, Grider J, et al. Cytokine-induced iNOS and ERK1/2 inhibit adenylyl cyclase type 5/6 activity and stimulate phosphodiesterase 4D5 activity in intestinal longitudinal smooth muscle. Am J Physiol Cell Physiol. 2014;307:C402-11 pubmed publisher
    ..b>AC5/6 and PDE4D5, expressed in circular muscle cells, were also expressed in longitudinal smooth muscle...
  23. Csukás D, Urbanics R, Moritz A, Ellis Behnke R. AC5 Surgical Hemostatâ„¢ as an effective hemostatic agent in an anticoagulated rat liver punch biopsy model. Nanomedicine. 2015;11:2025-31 pubmed publisher
    ..Using a rat liver puncture model, animals were treated with known synthetic peptide AC5 Surgical Hemostatic Deviceâ„¢, or saline controls...
  24. Tsunematsu T, Okumura S, Mototani Y, Ohnuki Y, Jin H, Cai W, et al. Coupling of β1-adrenergic receptor to type 5 adenylyl cyclase and its physiological relevance in cardiac myocytes. Biochem Biophys Res Commun. 2015;458:531-535 pubmed publisher
    ..but play opposite roles in cardiac apoptosis and heart failure, as do cardiac adenylyl cyclase (AC) subtypes 5 (AC5) and 6 (AC6): β1-AR and AC5 promote cardiac remodeling, while β2-AR and AC6 activate cell survival pathways...
  25. Bavencoffe A, Li Y, Wu Z, Yang Q, Herrera J, Kennedy E, et al. Persistent Electrical Activity in Primary Nociceptors after Spinal Cord Injury Is Maintained by Scaffolded Adenylyl Cyclase and Protein Kinase A and Is Associated with Altered Adenylyl Cyclase Regulation. J Neurosci. 2016;36:1660-8 pubmed publisher
    ..of adenylyl cyclase (AC) and cAMP-dependent protein kinase (PKA), as well as a scaffolded complex containing AC5/6, A-kinase anchoring protein 150 (AKAP150), and PKA...
  26. Dessauer C, Watts V, Ostrom R, Conti M, Dove S, Seifert R. International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. Pharmacol Rev. 2017;69:93-139 pubmed publisher
    ..For example, mutations in the AC5 gene (ADCY5) cause hyperkinetic extrapyramidal motor disorders...
  27. Wang R, Zhang N, Wang R, Wang S, Wang N. Two skin cell lines from wild-type and albino Japanese flounder (Paralichthys olivaceus): establishment, characterization, virus susceptibility, efficient transfection, and application to albinism study. Fish Physiol Biochem. 2017;43:1477-1486 pubmed publisher
    ..Finally, three genes involved in the melanogenesis pathway, including adenylate cyclase type 5 (adcy5), microphthalmia-associated transcription factor (mitf), and endothelin B receptor (ednrb), were ..
  28. van de Bunt M, Manning Fox J, Dai X, Barrett A, Grey C, Li L, et al. Transcript Expression Data from Human Islets Links Regulatory Signals from Genome-Wide Association Studies for Type 2 Diabetes and Glycemic Traits to Their Downstream Effectors. PLoS Genet. 2015;11:e1005694 pubmed publisher
    ..some, these data provide an experimental link between GWAS signals and biological candidates, such as DGKB and ADCY5. At others, the cis-signals implicate genes with no prior connection to islet biology, including WARS and ZMIZ1...
  29. Briceno G, Schalchli H, Rubilar O, Tortella G, Mutis A, Benimeli C, et al. Increased diazinon hydrolysis to 2-isopropyl-6-methyl-4-pyrimidinol in liquid medium by a specific Streptomyces mixed culture. Chemosphere. 2016;156:195-203 pubmed publisher
    ..strains AC5, AC9, GA11 and ISP13 were mixed; this was defined as the selected mixed culture (SMC)...
  30. Liang B, Li C, Zhao J. Identification of key pathways and genes in colorectal cancer using bioinformatics analysis. Med Oncol. 2016;33:111 pubmed publisher
    ..The top 10 hub genes, GNG2, AGT, SAA1, ADCY5, LPAR1, NMU, IL8, CXCL12, GNAI1, and CCR2 were identified from the PPI network, and sub-networks revealed these ..
  31. Barker A, Sharp S, Timpson N, Bouatia Naji N, Warrington N, Kanoni S, et al. Association of genetic Loci with glucose levels in childhood and adolescence: a meta-analysis of over 6,000 children. Diabetes. 2011;60:1805-12 pubmed publisher
    ..these associations reported in previous studies and five reported here for the first time (GLIS3, PROX1, SLC2A2, ADCY5, and CRY2)...
  32. Kim H, Kim T, Kim J, Park J, Lee Y, Kang M, et al. Adenylyl cyclase-5 in the dorsal striatum function as a molecular switch for the generation of behavioral preferences for cue-directed food choices. Mol Brain. 2014;7:77 pubmed publisher
    ..Mice lacking adenylyl cyclase-5 (AC5 KO mice), which is preferentially expressed in the dorsal striatum, consumed food pellets nearly one after another ..
  33. Willoughby D, Ong H, de Souza L, Wachten S, Ambudkar I, Cooper D. TRPC1 contributes to the Ca2+-dependent regulation of adenylate cyclases. Biochem J. 2014;464:73-84 pubmed publisher
    ..between Ca2+ and cAMP signalling in regulating the activity of Ca2+-sensitive adenylate cyclase isoforms (AC1, AC5, AC6 and AC8)...
  34. Amirul Alam M, Juraimi A, Rafii M, Hamid A, Aslani F, Alam M. Effects of salinity and salinity-induced augmented bioactive compounds in purslane (Portulaca oleracea L.) for possible economical use. Food Chem. 2015;169:439-47 pubmed publisher
    ..Purslane accessions Ac4, Ac5, Ac6 and Ac8 possessed potentials for salinity-induced augmented production of bioactive compounds which in turn ..
  35. Ho D, Zhao X, Yan L, Yuan C, Zong H, Vatner D, et al. Adenylyl Cyclase Type 5 Deficiency Protects Against Diet-Induced Obesity and Insulin Resistance. Diabetes. 2015;64:2636-45 pubmed publisher
    ..To determine the in vivo metabolic properties of AC5 deficiency, we compared the effects of standard diet (SD) and high-fat diet (HFD) on obesity, energy balance, ..
  36. Zhang J, Levy D, Oydanich M, Bravo C, Yoon S, Vatner D, et al. A novel adenylyl cyclase type 5 inhibitor that reduces myocardial infarct size even when administered after coronary artery reperfusion. J Mol Cell Cardiol. 2018;121:13-15 pubmed publisher
    We developed a novel adenylyl cyclase type 5 (AC5) inhibitor, C90, that reduces myocardial infarct size even when administered after coronary reperfusion...
  37. Sun X, Xiao X, Zhang Z, Liu Y, Xu T, Zhu X, et al. Positive Association Between Type 2 Diabetes Risk Alleles Near CDKAL1 and Reduced Birthweight in Chinese Han Individuals. Chin Med J (Engl). 2015;128:1873-8 pubmed publisher
    ..The aim of this study was to investigate whether common variants in genes CDKAL1, HHEX, ADCY5, SRR, PTPRD that predisposed to type 2 diabetes were also associated with reduced birthweight in Chinese Han ..
  38. Demizu Y, Doi M, Yamashita H, Misawa T, Oba M, Kurihara M, et al. The side-chain hydroxy groups of a cyclic ?,?-disubstituted ?-amino acid promote oligopeptide 310 -helix packing in the crystalline state. Biopolymers. 2016;106:757-68 pubmed publisher
    ..methoxymethyl (MOM) protecting groups, (3S,4S)-1-amino-(3,4-dimethoxymethoxy)cyclopentanecarboxylic acid [(S, S)-Ac5 c(dOMOM) ], or side-chain hydroxy groups, (3S,4S)-1-amino-(3,4-dihydroxy)cyclopentanecarboxylic acid [(S, S)-Ac5 c(..
  39. Balint B, Antelmi E, Mencacci N, Batla A, Eriksson S, Walker M, et al. Oculomotor apraxia and disrupted sleep with nocturnal ballistic bouts in ADCY5-related disease. Parkinsonism Relat Disord. 2018;54:103-106 pubmed publisher
    To characterise the distinctive eye movement disorder and the sleep-related dyskinesia in Adenylate cyclase 5 (ADCY5) related disease. Formal eye movement examination and video-polysomnography in a cohort of patients with ADCY5 mutations...
  40. Speth C, Schabetsberger T, Mohsenipour I, Stöckl G, Wurzner R, Stoiber H, et al. Mechanism of human immunodeficiency virus-induced complement expression in astrocytes and neurons. J Virol. 2002;76:3179-88 pubmed
    ..This strengthens the hypothesis that HIV-induced complement synthesis represents an important mechanism for the pathogenesis of AIDS in the brain. ..
  41. Dessauer C, Tesmer J, Sprang S, Gilman A. Identification of a Gialpha binding site on type V adenylyl cyclase. J Biol Chem. 1998;273:25831-9 pubmed
    ..The pseudosymmetrical structure of adenylyl cyclase permits bidirectional regulation of activity by homologous G protein alpha subunits. ..
  42. Arora G, Almgren P, Brøns C, Thaman R, Vaag A, Groop L, et al. Association between genetic risk variants and glucose intolerance during pregnancy in north Indian women. BMC Med Genomics. 2018;11:64 pubmed publisher
    ..02). Notably, T2D risk alleles of the variant rs1552224 near CENTD2, rs11708067 in ADCY5 and rs11605924 in CRY2 genes associated with protection from GDM regardless of criteria applied (p < 0.025)...
  43. Vuolo L, Herrera A, Torroba B, Menendez A, Pons S. Ciliary adenylyl cyclases control the Hedgehog pathway. J Cell Sci. 2015;128:2928-37 pubmed publisher
    ..Here, we show that adenylyl cyclase 5 and adenylyl cyclase 6 (AC5 and AC6, also known as ADCY5 and ADCY6, respectively) are the two isoforms most ..
  44. Patrizio M, Colucci M, Levi G. Human immunodeficiency virus type 1 Tat protein decreases cyclic AMP synthesis in rat microglia cultures. J Neurochem. 2001;77:399-407 pubmed
  45. Hingurao K, Nerurkar A. A Novel Methylotrophic Bacterial Consortium for Treatment of Industrial Effluents. Appl Biochem Biotechnol. 2018;185:691-704 pubmed publisher
    ..CETP) consortium comprising of Bordetella petrii AC1, Bacillus licheniformis AC4, Salmonella subterranea AC5, and Pseudomonas stutzeri AC8 was used...
  46. Sunahara R, Dessauer C, Whisnant R, Kleuss C, Gilman A. Interaction of Gsalpha with the cytosolic domains of mammalian adenylyl cyclase. J Biol Chem. 1997;272:22265-71 pubmed
    ..W., Scully, T. T., and Gilman, A. G. (1997) J. Biol. Chem. 272, 22272-22277) suggest that activators of adenylyl cyclase facilitate formation of a single, high-activity catalytic site at the interface between C1 and C2. ..
  47. Bravo C, Vatner D, Pachon R, Zhang J, Vatner S. A Food and Drug Administration-Approved Antiviral Agent that Inhibits Adenylyl Cyclase Type 5 Protects the Ischemic Heart Even When Administered after Reperfusion. J Pharmacol Exp Ther. 2016;357:331-6 pubmed publisher
    ..as vidarabine or adenine 9-β-D-arabinofuranoside (AraA), has features of inhibiting adenylyl cyclase type 5 (AC5) and protects against chronic coronary artery occlusion (CAO)...
  48. Cai W, Fujita T, Hidaka Y, Jin H, Suita K, Prajapati R, et al. Disruption of Epac1 protects the heart from adenylyl cyclase type 5-mediated cardiac dysfunction. Biochem Biophys Res Commun. 2016;475:1-7 pubmed publisher
    Type 5 adenylyl cyclase (AC5) plays an important role in the development of chronic catecholamine stress-induced heart failure and arrhythmia in mice...
  49. Seifert R. Does Vidarabine Mediate Cardioprotection via Inhibition of AC5?. J Pharmacol Exp Ther. 2016;358:242-3 pubmed publisher
    There is an ongoing discussion about the value of adenylyl cyclase 5 (AC5) as drug target for treatment of heart failure...
  50. Méneret A, Roze E. Paroxysmal movement disorders: An update. Rev Neurol (Paris). 2016;172:433-445 pubmed publisher
    ..The main genes involved in primary paroxysmal movement disorders include PRRT2, PNKD, SLC2A1, ATP1A3, GCH1, PARK2, ADCY5, CACNA1A and KCNA1...
  51. Guinzberg R, Díaz Cruz A, Acosta Trujillo C, Vilchis Landeros M, Vázquez Meza H, Lozano Flores C, et al. Newly synthesized cAMP is integrated at a membrane protein complex signalosome to ensure receptor response specificity. FEBS J. 2017;284:258-276 pubmed publisher
    ..In contrast, A2B -Ado-GPCR stimulation activates D-AKAP2-attached AC5 to generate cAMP, which is channeled to two other D-AKAP2-tethered proteins: guanine-nucleotide exchange factor 2 (..
  52. Procopio D, Saba L, Walter H, Lesch O, Skala K, Schlaff G, et al. Genetic markers of comorbid depression and alcoholism in women. Alcohol Clin Exp Res. 2013;37:896-904 pubmed publisher
    ..was in a genomic area in proximity to ADCY2, but actually within a lincRNA gene, 2 haplotypes were within ADCY5, and 1 haplotype was within the coding region of ADCY8...
  53. Knigge A, Klöting N, Schön M, Dietrich A, Fasshauer M, Gärtner D, et al. ADCY5 gene expression in adipose tissue is related to obesity in men and mice. PLoS ONE. 2015;10:e0120742 pubmed publisher
    Genome wide association studies revealed an association of the single nucleotide polymorphism rs11708067 within the ADCY5 gene--encoding adenylate cyclase 5--with increased type 2 diabetes (T2D) risk and higher fasting glucose...
  54. Česnek M, Jansa P, Šmídková M, Mertlíková Kaiserová H, Dračínský M, Brust T, et al. Bisamidate Prodrugs of 2-Substituted 9-[2-(Phosphonomethoxy)ethyl]adenine (PMEA, adefovir) as Selective Inhibitors of Adenylate Cyclase Toxin from Bordetella pertussis. ChemMedChem. 2015;10:1351-64 pubmed publisher
    ..ACT without cytotoxic effects as well as good selectivity over human adenylate cyclase isoforms AC1, AC2, and AC5. The most potent ACT inhibitor was found to be the bisamidate prodrug of the 2-fluoro PMEA derivative (IC50 =0...
  55. Brand C, Sadana R, Malik S, Smrcka A, Dessauer C. Adenylyl Cyclase 5 Regulation by Gβγ Involves Isoform-Specific Use of Multiple Interaction Sites. Mol Pharmacol. 2015;88:758-67 pubmed publisher
    ..We previously showed that the Gαs-βγ heterotrimer binds to the N terminus (NT) of type 5 AC (AC5). We now show that Gβγ binds to the NT of a wide variety of AC isoforms...
  56. Nakano S, Sucharov J, van Dusen R, Cecil M, Nunley K, Wickers S, et al. Cardiac Adenylyl Cyclase and Phosphodiesterase Expression Profiles Vary by Age, Disease, and Chronic Phosphodiesterase Inhibitor Treatment. J Card Fail. 2017;23:72-80 pubmed publisher
    ..There was unique up-regulation of AC5 in adult DCM with PDE3i (fold change 2.415; P?=?.043), AC2 in pediatric DCM (fold change 2.396; P?=?...
  57. del Puerto A, Díaz Hernández J, Tapia M, Gomez Villafuertes R, Benitez M, Zhang J, et al. Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation. J Cell Sci. 2012;125:176-88 pubmed publisher
  58. Efendiev R, Samelson B, Nguyen B, Phatarpekar P, Baameur F, Scott J, et al. AKAP79 interacts with multiple adenylyl cyclase (AC) isoforms and scaffolds AC5 and -6 to alpha-amino-3-hydroxyl-5-methyl-4-isoxazole-propionate (AMPA) receptors. J Biol Chem. 2010;285:14450-8 pubmed publisher
    ..We previously showed that AKAP79/150 clusters PKA with type 5 adenylyl cyclase (AC5) to assemble a negative feedback loop in which the anchored kinase phosphorylates AC5 to dynamically suppress cAMP ..
  59. Kottler V, Künstner A, Koch I, Flötenmeyer M, Langenecker T, Hoffmann M, et al. Adenylate cyclase 5 is required for melanophore and male pattern development in the guppy (Poecilia reticulata). Pigment Cell Melanoma Res. 2015;28:545-58 pubmed publisher
    ..the blond phenotype of the guppy is caused by a spontaneous mutation in the guppy ortholog of adenylate cyclase 5 (adcy5)...
  60. Bogard A, Xu C, Ostrom R. Human bronchial smooth muscle cells express adenylyl cyclase isoforms 2, 4, and 6 in distinct membrane microdomains. J Pharmacol Exp Ther. 2011;337:209-17 pubmed publisher
    ..2)AR, but not prostanoid EP(2) or EP(4) receptors, colocalized with AC5/6 in lipid raft fractions...
  61. Li F, Xu X, Huang C, Gu Z, Cao L, Hu T, et al. The AC5 protein encoded by Mungbean yellow mosaic India virus is a pathogenicity determinant that suppresses RNA silencing-based antiviral defenses. New Phytol. 2015;208:555-69 pubmed publisher
    ..Although AC5/C5 coding sequences are increasingly annotated in databases for many begomoviruses, the evolutionary relationships ..
  62. Volkov P, Bacos K, Ofori J, Esguerra J, Eliasson L, Rönn T, et al. Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis. Diabetes. 2017;66:1074-1085 pubmed publisher
    ..These DMRs cover loci with known islet function, e.g., PDX1, TCF7L2, and ADCY5 Importantly, binding sites previously identified by ChIP-seq for islet-specific transcription factors, ..
  63. Chen H, Cai W, Chu E, Tang J, Wong C, Wong S, et al. Hepatic cyclooxygenase-2 overexpression induced spontaneous hepatocellular carcinoma formation in mice. Oncogene. 2017;36:4415-4426 pubmed publisher
    ..DNA methylation and gene expression profiles further identified significantly downregulated genes including LTBP1, ADCY5 and PRKCZ by promoter methylation in COX-2-induced HCC...
  64. Zalduegui A, López de Jesús M, Callado L, Meana J, Salles J. Levels of Gs?(short and long), G?(olf) and G?(common) subunits, and calcium-sensitive adenylyl cyclase isoforms (1, 5/6, 8) in post-mortem human brain caudate and cortical membranes: comparison with rat brain membranes and potential stoichiometric re. Neurochem Int. 2011;58:180-9 pubmed publisher
    ..The highest levels of AC5/6 expression were detected in caudate membranes...
  65. Kim H, Lee Y, Park J, Kim J, Kim T, Choi J, et al. Loss of Adenylyl Cyclase Type-5 in the Dorsal Striatum Produces Autistic-Like Behaviors. Mol Neurobiol. 2017;54:7994-8008 pubmed publisher
    ..that genetic or molecular disruption of an array of molecular networks centered on adenylyl cyclase type-5 (AC5 or ADCY5) in the dorsal striatum produces autistic-like behaviors...
  66. Jaggupilli A, Dhanaraj P, Pritchard A, Sorensen J, Dakshinamurti S, Chelikani P. Study of adenylyl cyclase-GαS interactions and identification of novel AC ligands. Mol Cell Biochem. 2018;446:63-72 pubmed publisher
    ..There are 9 AC isoforms present in humans, with AC5 and AC6 proposed to play a vital role in cardiac functions...
  67. Xie K, Masuho I, Shih C, Cao Y, Sasaki K, Lai C, et al. Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling. elife. 2015;4: pubmed publisher
    ..Critical to this process is the effector enzyme adenylyl cyclase type 5 (AC5) that produces second messenger cAMP upon receptor-mediated activation by G protein Golf...
  68. Pongsapipatana N, Damrongteerapap P, Chantorn S, Sintuprapa W, Keawsompong S, Nitisinprasert S. Molecular cloning of kman coding for mannanase from Klebsiella oxytoca KUB-CW2-3 and its hybrid mannanase characters. Enzyme Microb Technol. 2016;89:39-51 pubmed publisher
    ..36-0.83h(-1). H-LBG was more specific to 3 species of Weissella confusa JCM 1093, Lactobacillus reuteri KUB-AC5, Lb salivarius KL-D4 and E. coli E010 while both H-KGM and H-DCM were to Lb. reuteri KUB-AC5 and Lb...
  69. Carecchio M, Mencacci N. Emerging Monogenic Complex Hyperkinetic Disorders. Curr Neurol Neurosci Rep. 2017;17:97 pubmed publisher
    ..This review will explore the main features of these newly identified conditions. Mutations in ADCY5 and PDE10A have been identified as important causes of childhood-onset dyskinesias and KMT2B mutations as one of ..
  70. Johnstone T, Smith K, Koziol White C, Li F, Kazarian A, Corpuz M, et al. PDE8 is Expressed in Human Airway Smooth Muscle and Selectively Regulates cAMP Signaling by β2AR-AC6. Am J Respir Cell Mol Biol. 2017;: pubmed publisher
    ..raft fractionation of HASM cells revealed PDE8A immunoreactivity in buoyant fractions containing caveolin-1 and AC5/6 immunoreactivity...
  71. Boesgaard T, Grarup N, Jørgensen T, Borch Johnsen K, Hansen T, Pedersen O. Variants at DGKB/TMEM195, ADRA2A, GLIS3 and C2CD4B loci are associated with reduced glucose-stimulated beta cell function in middle-aged Danish people. Diabetologia. 2010;53:1647-55 pubmed publisher
    ..Eleven variants in or near DGKB/TMEM195, ADCY5, MADD, ADRA2A, FADS1, CRY2, SLC2A2, GLIS3, PROX1, C2CD4B and IGF1 were genotyped in 6,784 middle-aged participants ..
  72. Mook Kanamori D, Marsh J, Warrington N, Taal H, Newnham J, Beilin L, et al. Variants near CCNL1/LEKR1 and in ADCY5 and fetal growth characteristics in different trimesters. J Clin Endocrinol Metab. 2011;96:E810-5 pubmed publisher
    A recent genome-wide association study identified variants near CCNL1/LEKR1 (rs900400) and in ADCY5 (rs9883204) to be associated with birth weight...
  73. Friedman J, Méneret A, Chen D, Trouillard O, Vidailhet M, Raskind W, et al. ADCY5 mutation carriers display pleiotropic paroxysmal day and nighttime dyskinesias. Mov Disord. 2016;31:147-8 pubmed publisher
  74. Roman T, Cannon M, Vadlamudi S, Buchkovich M, Wolford B, Welch R, et al. A Type 2 Diabetes-Associated Functional Regulatory Variant in a Pancreatic Islet Enhancer at the ADCY5 Locus. Diabetes. 2017;66:2521-2530 pubmed publisher
    ..Variants associated with type 2 diabetes and fasting glucose levels reside in introns of ADCY5, a gene that encodes adenylate cyclase 5...
  75. Cote M, Guillon G, Payet M, Gallo Payet N. Expression and regulation of adenylyl cyclase isoforms in the human adrenal gland. J Clin Endocrinol Metab. 2001;86:4495-503 pubmed
    ..at the membrane level, adenylyl cyclases 3 and 2 in both the cytoplasm and the plasma membrane, whereas adenylyl cyclase 5/6 and adenylyl cyclase 4 were found mainly in cytoplasm...
  76. Zhang G, Feenstra B, Bacelis J, Liu X, Muglia L, Juodakis J, et al. Genetic Associations with Gestational Duration and Spontaneous Preterm Birth. N Engl J Med. 2017;377:1156-1167 pubmed publisher
    ..The association between variants in ADCY5 and RAP2C and gestational duration had suggestive significance in the discovery set and significant evidence of ..
  77. Douglas A, Andreoletti G, Talbot K, Hammans S, Singh J, Whitney A, et al. ADCY5-related dyskinesia presenting as familial myoclonus-dystonia. Neurogenetics. 2017;18:111-117 pubmed publisher
    ..autosomal dominant familial dyskinesia resembling myoclonus-dystonia associated with a novel missense mutation in ADCY5, found through whole-exome sequencing...
  78. Zech M, Jech R, Wagner M, Mantel T, Boesch S, Nocker M, et al. Molecular diversity of combined and complex dystonia: insights from diagnostic exome sequencing. Neurogenetics. 2017;18:195-205 pubmed publisher
    ..Whereas mutations in ACTB, ATP1A3, ADCY5, and SGCE were associated with particular phenotypic clues, trait manifestations arising from mutations in PINK1, ..
  79. Speth C, Joebstl B, Barcova M, Dierich M. HIV-1 envelope protein gp41 modulates expression of interleukin-10 and chemokine receptors on monocytes, astrocytes and neurones. AIDS. 2000;14:629-36 pubmed
    ..Expression of the chemokine receptor CXCR4 was only slightly altered. These findings suggest a role for gp41 in the modulation of brain-specific host defence, cell migration and cell infectivity by HIV. ..
  80. Gao X, Sadana R, Dessauer C, Patel T. Conditional stimulation of type V and VI adenylyl cyclases by G protein betagamma subunits. J Biol Chem. 2007;282:294-302 pubmed
    ..Moreover, Gbetagamma subunits derived from a source(s) other than G(i) are necessary for the full activation of hACVI by isoproterenol in intact cells. ..
  81. Carecchio M, Mencacci N, Iodice A, Pons R, Panteghini C, Zorzi G, et al. ADCY5-related movement disorders: Frequency, disease course and phenotypic variability in a cohort of paediatric patients. Parkinsonism Relat Disord. 2017;41:37-43 pubmed publisher
    b>ADCY5 mutations have been recently identified as an important cause of early-onset hyperkinetic movement disorders. The phenotypic spectrum associated with mutations in this gene is expanding...
  82. Iwami G, Kawabe J, Ebina T, Cannon P, Homcy C, Ishikawa Y. Regulation of adenylyl cyclase by protein kinase A. J Biol Chem. 1995;270:12481-4 pubmed
    ..Our results indicate that AC catalytic activity can be regulated through PKA-mediated phosphorylation, suggesting another mechanism of desensitization for receptor pathways which signal via increases in intracellular cAMP. ..
  83. Scholich K, Wittpoth C, Barbier A, Mullenix J, Patel T. Identification of an intramolecular interaction between small regions in type V adenylyl cyclase that influences stimulation of enzyme activity by Gsalpha. Proc Natl Acad Sci U S A. 1997;94:9602-7 pubmed
    ..We conclude that the C1b region of ACV interacts with the 10-aa region (L1042-T1051) in the C2 domain of the enzyme to modulate Gsalpha-elicited stimulation of activity. ..
  84. Yu P, Sun M, Villar V, Zhang Y, Weinman E, Felder R, et al. Differential dopamine receptor subtype regulation of adenylyl cyclases in lipid rafts in human embryonic kidney and renal proximal tubule cells. Cell Signal. 2014;26:2521-9 pubmed publisher
    ..Of the AC isoforms expressed in HEK and hRPT cells (AC3, AC5, AC6, AC7, and AC9), AC5/6 was distributed to a greater extent in LRs than non-LRs in HEK-hD1R (84.5±2...
  85. Mencacci N, Erro R, Wiethoff S, Hersheson J, Ryten M, Balint B, et al. ADCY5 mutations are another cause of benign hereditary chorea. Neurology. 2015;85:80-8 pubmed publisher
    To determine the contribution of ADCY5 mutations in cases with genetically undefined benign hereditary chorea (BHC). We studied 18 unrelated cases with BHC (7 familial, 11 sporadic) who were negative for NKX2-1 mutations...
  86. Parks R, Bogachev O, Mackasey M, Ray G, Rose R, Howlett S. The impact of ovariectomy on cardiac excitation-contraction coupling is mediated through cAMP/PKA-dependent mechanisms. J Mol Cell Cardiol. 2017;111:51-60 pubmed publisher
    ..Consistent with this, mRNA levels for both AC5 and PDE4A were higher in OVX in comparison to sham...
  87. Guo Y, Liu C, Zhang L, Wang M, Chen H. Sterol content in the artificial diet of Mythimna separata affects the metabolomics of Arma chinensis (Fallou) as determined by proton nuclear magnetic resonance spectroscopy. Arch Insect Biochem Physiol. 2017;96: pubmed publisher
    ..glycine, methylamine, and sarcosine) differed significantly between the control (AC0) and treated (AC1, AC2, and AC5) groups...
  88. Haber N, Stengel D, Defer N, Roeckel N, Mattei M, Hanoune J. Chromosomal mapping of human adenylyl cyclase genes type III, type V and type VI. Hum Genet. 1994;94:69-73 pubmed
    ..2-3q21, and the type VI gene on chromosome 12 at position 12q12-12q13. It therefore appears that all adenylyl cyclase genes, known at present are located on different chromosomes and thus are likely to be independently regulated. ..
  89. Tong W, Wierda W, Lin E, Kuang S, Bekele B, Estrov Z, et al. Genome-wide DNA methylation profiling of chronic lymphocytic leukemia allows identification of epigenetically repressed molecular pathways with clinical impact. Epigenetics. 2010;5:499-508 pubmed
    ..Methylation status was confirmed for 22 of these genes (SOX11, DLX1, FAM62C, SOX14, RSPO1, ADCY5, HAND2,SPOCK, MLL, ING1, PRIMA1, BCL11B, LTBP2, BNC1, NR2F2, SALL1, GALGT2, LHX1, DLX4, KLK10, TFAP2 and APP) in ..
  90. Westenberger A, Max C, Brüggemann N, Domingo A, Grütz K, Pawlack H, et al. Alternating Hemiplegia of Childhood as a New Presentation of Adenylate Cyclase 5-Mutation-Associated Disease: A Report of Two Cases. J Pediatr. 2017;181:306-308.e1 pubmed publisher
    Mutations in the adenylate cyclase 5 (ADCY5) gene recently have been identified as the cause of a childhood-onset disorder characterized by persistent or paroxysmal choreic, myoclonic, and/or dystonic movements...
  91. Wang Q, Cobo Stark P, Patel V, Somlo S, Han P, Igarashi P. Adenylyl cyclase 5 deficiency reduces renal cyclic AMP and cyst growth in an orthologous mouse model of polycystic kidney disease. Kidney Int. 2018;93:403-415 pubmed publisher
    ..primary cilium of renal epithelial cells contains a cAMP regulatory complex comprising adenylyl cyclases 5 and 6 (AC5/6), polycystin-2, A-kinase anchoring protein 150, protein kinase A, and phosphodiesterase 4C...
  92. Sunahara R, Taussig R. Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Mol Interv. 2002;2:168-84 pubmed