ADCY10

Summary

Gene Symbol: ADCY10
Description: adenylate cyclase 10
Alias: HCA2, HEL-S-7a, SAC, SACI, Sacy, hsAC, adenylate cyclase type 10, 3',5'-cyclic AMP synthetase, AH-related protein, ATP pyrophosphate-lyase, adenylate cyclase 10, soluble, epididymis secretory sperm binding protein Li 7a, germ cell soluble adenylyl cyclase, testicular soluble adenylyl cyclase (SAC)
Species: human
Products:     ADCY10

Top Publications

  1. Zippin J, Chen Y, Nahirney P, Kamenetsky M, Wuttke M, Fischman D, et al. Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains. FASEB J. 2003;17:82-4 pubmed
    ..source of cAMP in mammalian cells lacking transmembrane spanning domains, the "soluble" adenylyl cyclase (sAC)...
  2. Hess K, Jones B, Marquez B, Chen Y, Ord T, Kamenetsky M, et al. The "soluble" adenylyl cyclase in sperm mediates multiple signaling events required for fertilization. Dev Cell. 2005;9:249-59 pubmed
    ..Male mice lacking the bicarbonate- and calcium-responsive soluble adenylyl cyclase (sAC), the predominant source of cAMP in male germ cells, are infertile, as the sperm are immotile...
  3. Chen Y, Cann M, Litvin T, Iourgenko V, Sinclair M, Levin L, et al. Soluble adenylyl cyclase as an evolutionarily conserved bicarbonate sensor. Science. 2000;289:625-8 pubmed
    ..potential; however, we demonstrate here that bicarbonate directly stimulates mammalian soluble adenylyl cyclase (sAC) activity in vivo and in vitro in a pH-independent manner...
  4. Geng W, Wang Z, Zhang J, Reed B, Pak C, Moe O. Cloning and characterization of the human soluble adenylyl cyclase. Am J Physiol Cell Physiol. 2005;288:C1305-16 pubmed
    We identified the human ortholog of soluble adenylyl cyclase (hsAC) in a locus linked to familial absorptive hypercalciuria and cloned it from a human cDNA library...
  5. Sunahara R, Taussig R. Isoforms of mammalian adenylyl cyclase: multiplicities of signaling. Mol Interv. 2002;2:168-84 pubmed
  6. Schmid A, Sutto Z, Nlend M, Horvath G, Schmid N, Buck J, et al. Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP. J Gen Physiol. 2007;130:99-109 pubmed
    ..during exacerbations of airway diseases, but the role of CO(2)/HCO(3)(-)-sensitive soluble adenylyl cyclase (sAC) in ciliary beat regulation is unknown...
  7. Litvin T, Kamenetsky M, Zarifyan A, Buck J, Levin L. Kinetic properties of "soluble" adenylyl cyclase. Synergism between calcium and bicarbonate. J Biol Chem. 2003;278:15922-6 pubmed
    quot;Soluble" adenylyl cyclase (sAC) is a widely expressed source of cAMP in mammalian cells that is evolutionarily, structurally, and biochemically distinct from the G protein-responsive transmembrane adenylyl cyclases...
  8. Buck J, Sinclair M, Schapal L, Cann M, Levin L. Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals. Proc Natl Acad Sci U S A. 1999;96:79-84 pubmed
    ..Northern analysis indicates the gene encoding soluble adenylyl cyclase (sAC) is preferentially expressed in testis...
  9. Reed B, Heller H, Gitomer W, Pak C. Mapping a gene defect in absorptive hypercalciuria to chromosome 1q23.3-q24. J Clin Endocrinol Metab. 1999;84:3907-13 pubmed
    ..3-megabase region between markers D1S2681 (centromere) and D1S2815. A trait associated with intestinal hyperabsorption of calcium in a severe form of absorptive hypercalciuria has been mapped to chromosome 1q23.3-q24. ..

More Information

Publications138 found, 100 shown here

  1. Reed B, Gitomer W, Heller H, Hsu M, Lemke M, Padalino P, et al. Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density. J Clin Endocrinol Metab. 2002;87:1476-85 pubmed
    ..This is the first description of a specific gene defect associated with AH. ..
  2. Jaiswal B, Conti M. Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase. J Biol Chem. 2001;276:31698-708 pubmed
    ..on two forms of adenylyl cyclase, the conventional membrane-bound ACIII and a soluble form of adenylyl cyclase (sAC)...
  3. Babizhayev M, Yegorov Y. Telomere Attrition in Human Lens Epithelial Cells Associated with Oxidative Stress Provide a New Therapeutic Target for the Treatment, Dissolving and Prevention of Cataract with N-Acetylcarnosine Lubricant Eye Drops. Kinetic, Pharmacological and Acti. Recent Pat Drug Deliv Formul. 2016;10:82-129 pubmed
    ..sources as well as a timing dosage and duration systemic absorption of said preparation from the conjunctional sac reaching the hypothalamus with activities transfer into the hypothalamic-neuroendocrine pathways affecting across ..
  4. Lin T, Yu J, Hu Y, Liu H, Lu Y, Zhao M, et al. [Preliminary experience of dual-port laparoscopic distal gastrectomy for gastric cancer]. Zhonghua Wei Chang Wai Ke Za Zhi. 2019;22:35-42 pubmed
    ..Surgical procedure was as follows: conventional laparoscopic instruments were used. After entering the omental sac, dissection was performed along the transverse colon to the spleen flexure...
  5. Yi P, Niu H, Gao Q, Wang F, Jia W, Chen Z, et al. [Pathologic features on gonadal changes of sexual developmental disorders in children]. Zhonghua Bing Li Xue Za Zhi. 2018;47:531-535 pubmed publisher
    ..tissue embedded in malignant mixed germ cell tumors (mixed gonadoblastoma, dysgerminoma, mature teratoma and yolk sac tumor). One case had testicular microlithiasis. Uterus and fallopian tube structures were found in 11 cases...
  6. Reith W, Mühl Benninghaus R, Simgen A, Yilmaz U. [Germ cell and embryonal tumors]. Radiologe. 2014;54:772-82 pubmed publisher
    ..3-5% of tumors of the central nervous system (CNS), can be subdivided into germinomas, embryonal carcinomas, yolk sac tumors, choriocarcinomas, teratomas and mixed germ cell tumors...
  7. Muthulakshmi S, Maharajan K, Habibi H, Kadirvelu K, Venkataramana M. Zearalenone induced embryo and neurotoxicity in zebrafish model (Danio rerio): Role of oxidative stress revealed by a multi biomarker study. Chemosphere. 2018;198:111-121 pubmed publisher
    ..The results shows that ZEA induces developmental defects like pericardial edema, hyperemia, yolk sac edema, spine curvature and reduction in heart rate from above 550??g/L exposure and the severity was increased with ..
  8. Smith R, Moccia R, Seymour C, Mothersill C. Irradiation of rainbow trout at early life stages results in a proteomic legacy in adult gills. Part A; proteomic responses in the irradiated fish and in non-irradiated bystander fish. Environ Res. 2018;163:297-306 pubmed publisher
    Exposure to a single 0.5 Gy X-ray dose of eggs at 48 h after fertilisation (48 h egg), eyed eggs, yolk sac larvae (YSL) and first feeders induces a legacy effect in adult rainbow trout...
  9. Gao L, Wang L, Yang X, Wang Y, Liu Z, Xu B, et al. Role of a serine protease gene (AccSp1) from Apis cerana cerana in abiotic stress responses and innate immunity. Cell Stress Chaperones. 2019;24:29-43 pubmed publisher
    ..AccSp1 was expressed at its highest level in the venom gland and epidermis than tentacle, abdomen, muscle, honey sac, head, leg, chest, hemolymph, rectum, and midgut...
  10. Cosentino F, Rossitto C, Turco L, Gueli Alletti S, Vascone C, Di Meglio L, et al. Laparoscopic Management of Abdominal Pregnancy. J Minim Invasive Gynecol. 2017;24:724-725 pubmed publisher
    ..Abdominal pregnancy can be localized in the pelvic cul-de-sac, broad ligament, bowel, or pelvic sidewall...
  11. van Sonsbeek S, Pullens B, van Benthem P. Positive pressure therapy for Ménière's disease or syndrome. Cochrane Database Syst Rev. 2015;:CD008419 pubmed publisher
    ..g. a low-salt diet) and medication (e.g. betahistine (Serc®), diuretics) to extensive surgery (e.g. endolymphatic sac surgery)...
  12. Pirtea L, Balint O, Secoşan C, Grigoraş D, Ilina R. Laparoscopic Resection of Cesarean Scar Ectopic Pregnancy after Unsuccessful Systemic Methotrexate Treatment. J Minim Invasive Gynecol. 2019;26:399-400 pubmed publisher
    ..A uterine manipulator was used to facilitate the dissection. The exact location of the gestational sac was demonstrated using intraoperative transvaginal ultrasound...
  13. Menges A, Busch A, Reutersberg B, Trenner M, Kath P, Chernogubova E, et al. The structural atrophy of the aneurysm wall in secondary expanding aortic aneurysms with endoleak type II. J Vasc Surg. 2019;: pubmed publisher
    ..Type II EL occurs in up to 30% of procedures; however, aneurysm sac expansion and rupture are rare, and currently nothing is known about the morphologic changes in this condition...
  14. Gilligan T. Decision Making in a Data-Poor Environment: Management of Brain Metastases From Testicular and Extragonadal Germ Cell Tumors. J Clin Oncol. 2016;34:303-6 pubmed publisher
    ..His previous treatment included orchiectomy, which revealed a 5-cm tumor that was 95% yolk sac tumor and 5% embryonal carcinoma, and retroperitoneal lymph node dissection for clinical stage I disease in January ..
  15. Sharon J, Trevino C, Schubert M, Carey J. Treatment of Menière's Disease. Curr Treat Options Neurol. 2015;17:341 pubmed publisher
    ..Next tier treatments include the Meniett device and endolymphatic sac surgery, but the efficacy of both is controversial...
  16. Ouyang Y, Tan Y, Yi Y, Gong F, Lin G, Li X, et al. Correlation between chromosomal distribution and embryonic findings on ultrasound in early pregnancy loss after IVF-embryo transfer. Hum Reprod. 2016;31:2212-8 pubmed publisher
    ..50%, P ? 0.001). In the anembryonic group, the abnormal karyotype rate was significantly higher in the yolk sac only than that in the empty sac group (46.11% versus 29.77%, P = 0...
  17. Barel O, Suday R, Stanleigh J, Pansky M. Laparoscopic Removal of an Abdominal Pregnancy in the Pelvic Sidewall. J Minim Invasive Gynecol. 2019;: pubmed publisher
    ..A transvaginal ultrasound (TVUS) exam on presentation did not demonstrate an intrauterine gestational sac, but revealed a gestational sac and a fetus next to the right adnexa, with a crown-rump length of 1...
  18. Sathibabu Uddandrao V, BrahmaNaidu P, RavindarNaik R, Suresh P, Vadivukkarasi S, Saravanan G. Restorative potentiality of S-allylcysteine against diabetic nephropathy through attenuation of oxidative stress and inflammation in streptozotocin-nicotinamide-induced diabetic rats. Eur J Nutr. 2018;: pubmed publisher
    In the present study, we evaluated the therapeutic potentiality of S-allylcysteine (SAC) in streptozotocin (STZ)-nicotinamide (NAD)-induced diabetic nephropathy (DN) in experimental rats...
  19. Quintaneiro C, Teixeira B, Benedé J, Chisvert A, Soares A, Monteiro M. Toxicity effects of the organic UV-filter 4-Methylbenzylidene camphor in zebrafish embryos. Chemosphere. 2019;218:273-281 pubmed publisher
    ..morphological abnormalities during embryonic development, including notochord curvature, delayed absorption of yolk sac and pericardial oedema. Concentration of 0.77 mg/l 4-MBC decreased embryo heart rate at 48h...
  20. Srinivasan P, Balasubramaniam G, Murthy T, Balachandran P. Pathomorphological studies of polyserositis in commercial caged layer chicken. Asian Pac J Trop Med. 2014;7S1:S313-20 pubmed publisher
    ..Vascular derangements and infiltration of inflammatory cells showed in the lungs and air sac. Fibrinous polyserositis, focal necrosis and infiltration of inflammatory cells showed in parenchyma of heart and ..
  21. Iturri L, Saenz Coronilla J, Lallemand Y, Gomez Perdiguero E. Identification Of Erythromyeloid Progenitors And Their Progeny In The Mouse Embryo By Flow Cytometry. J Vis Exp. 2017;: pubmed publisher
    ..Recent investigations have identified that resident macrophages originate from the extra-embryonic yolk sac hematopoiesis from progenitor(s) distinct from fetal hematopoietic stem cells (HSC)...
  22. Zanatta A, de Carvalho B, Amaral K, Polcheira P, de Sousa J, Zaconeta A. Laparoscopic interval isthmocervical cerclage with cardiac tape in a patient with previous cervical amputation. J Minim Invasive Gynecol. 2015;22:536-7 pubmed publisher
    ..We incised the visceral peritoneum in the anterior cul-de-sac and developed the vesicouterine space for complete exposure of the uterine isthmus...
  23. Harris C, Jilek J, Sant K, Pohl J, Reed M, Hansen J. Amino acid starvation induced by protease inhibition produces differential alterations in redox status and the thiol proteome in organogenesis-stage rat embryos and visceral yolk sacs. J Nutr Biochem. 2015;26:1589-98 pubmed publisher
    ..The near complete loss of acid soluble fluorescence and increased total visceral yolk sac (VYS) protein content confirmed the selective inhibition of proteolysis...
  24. Lo H, Tsai C, Chen C, Wang L, Lee Y, Chen C, et al. Association of dysfunctional synapse defective 1 (SYDE1) with restricted fetal growth - SYDE1 regulates placental cell migration and invasion. J Pathol. 2017;241:324-336 pubmed publisher
    ..ablation of murine Syde1 results in small fetuses and placentas with aberrant phenotypes in the placental-yolk sac barrier, maternal-trophoblast interface, and placental vascularization...
  25. Santagostino S, Arbona R, Nashat M, White J, Monette S. Pathology of Aging in NOD scid gamma Female Mice. Vet Pathol. 2017;54:855-869 pubmed publisher
    ..and degenerative lesions of the genital tract were identified, along with neoplasms such as endometrial yolk sac carcinomas and granulosa cell tumors...
  26. Aycan A, Çelik S, Kuyumcu F, Akyol M, Arslan M, Doğan E, et al. Spinal Metastasis of Unknown Primary Accompanied by Neurologic Deficit or Vertebral Instability. World Neurosurg. 2018;109:e33-e42 pubmed publisher
    ..n = 1), plasmacytoma (n = 1), bladder cancer (n = 1), paraganglioma (n = 1), Ewing sarcoma (n = 1), and yolk sac carcinoma (n = 1). Posterior instrumentation was performed in patients with instability...
  27. Nuñez L, Santander Parra S, Carranza C, Astolfi Ferreira C, Buim M, Piantino Ferreira A. Detection and molecular characterization of chicken astrovirus associated with chicks that have an unusual condition known as "white chicks" in Brazil. Poult Sci. 2016;95:1262-70 pubmed publisher
    ..intestines, pancreas, proventriculus, gizzard, liver, spleen, bursa, kidneys, thymus, lung, heart, brain, and yolk sac in each chick...
  28. Anandasadagopan S, Sundaramoorthy C, Pandurangan A, Nagarajan V, Srinivasan K, Ganapasam S. S-Allyl cysteine alleviates inflammation by modulating the expression of NF-?B during chromium (VI)-induced hepatotoxicity in rats. Hum Exp Toxicol. 2017;36:1186-1200 pubmed publisher
    ..S-allyl cysteine (SAC) is a constituent of garlic ( Allium sativum) and has many beneficial effects to humans and rodents...
  29. Khunphonoi R, Khamdahsag P, Chiarakorn S, Grisdanurak N, Paerungruang A, Predapitakkun S. Enhancement of elemental mercury adsorption by silver supported material. J Environ Sci (China). 2015;32:207-16 pubmed publisher
    ..before testing against a commercial adsorbent (sulfur-impregnated activated carbon, SAC). The adsorption isotherm, kinetics, and its thermodynamics of mercury adsorption were reported...
  30. Colgan F, Bungay P, Burfitt N, Hatrick A, Clarke M, Davies A, et al. Operative and 1-Year Outcomes of the Custom-Made Fenestrated Anaconda Aortic Stent Graft-A UK Multicenter Study. Ann Vasc Surg. 2018;46:257-264 pubmed publisher
    ..8% showing reduction in abdominal aortic aneurysm diameter and only 1 patient with sac expansion. Freedom from loss of TVP was 97.6%...
  31. Ueda K, Kanaya H, Higashi K, Yamamoto K, Moribe K. Molecular-level elucidation of saccharin-assisted rapid dissolution and high supersaturation level of drug from Eudragit® E solid dispersion. Int J Pharm. 2018;538:57-64 pubmed publisher
    In this work, the effect of saccharin (SAC) addition on the dissolution and supersaturation level of phenytoin (PHT)/Eudragit® E (EUD-E) solid dispersion (SD) at neutral pH was examined...
  32. Chen J, Ma H, Zheng Y, Cao J, Zeng H, Zhang Q. [Trisomy 21 syndrome associated interstitial lung disease: a case report]. Zhonghua Er Ke Za Zhi. 2015;53:771-4 pubmed
    ..Pathological examination indicated that alveolar, alveolar ducts and alveolar sac were enlarged, alveolar septa was expanded...
  33. Ducasse A, Arndt C, Brugniart C, Larre I. [Lacrimal traumatology]. J Fr Ophtalmol. 2016;39:213-8 pubmed publisher
    ..Other lacrimal tract injuries involving the lacrimal sac or the nasolacrimal duct are rare, commonly associated with blunt craniofacial trauma or iatrogenic after some ..
  34. Crispo M, Palmieri C, Shivaprasad H. Myopathy of the Pipping Muscles, Hepatosis Dietetica, and Cataracts in Emu Chicks (Dromaius Novaehollandiae). Vet Pathol. 2016;53:1248-1251 pubmed
    ..of the pipping muscles in the proximal neck (71%), pale liver with hemorrhages (71%), noninternalized residual yolk sac (86%) and anasarca (14%)...
  35. Hansen B, Jager T, Altin D, Øverjordet I, Olsen A, Salaberria I, et al. Acute toxicity of dispersed crude oil on the cold-water copepod Calanus finmarchicus: Elusive implications of lipid content. J Toxicol Environ Health A. 2016;79:549-57 pubmed publisher
    ..The only marked difference between the studies is that copepods in the first experiment displayed a lower lipid sac volume (on average) than in the second one...
  36. Presnell J, Vandepas L, Warren K, Swalla B, Amemiya C, Browne W. The Presence of a Functionally Tripartite Through-Gut in Ctenophora Has Implications for Metazoan Character Trait Evolution. Curr Biol. 2016;26:2814-2820 pubmed publisher
    ..of gut evolution assumes that non-bilaterian metazoan lineages either lack a gut (Porifera and Placozoa) or have a sac-like gut (Ctenophora and Cnidaria) and that a through-gut originated within Bilateria [1-8]...
  37. Gelardi M, Taliente S, Piccininni K, Silvestre G, Quaranta N, Ciprandi G. Nasal irrigation with Nasir® in children: a preliminary experience on nasal cytology. J Biol Regul Homeost Agents. 2016;30:1125-1130 pubmed
    ..The patients were treated with nasal irrigation with warm (36°C) Nasir® (250 mL sacs of premixed solution): one sac twice daily for 12 days...
  38. Mazzaccaro D, Carmo M, Dallatana R, Settembrini A, Barbetta I, Tassinari L, et al. Comparison of posterior and medial approaches for popliteal artery aneurysms. J Vasc Surg. 2015;62:1512-20 pubmed publisher
    ..Mean age was 68 years (range, 48-96 years). Thirty-six aneurysms were asymptomatic (47%). Mean sac diameter was 2.8 ± 1 cm. A PA was used in 43 PAAs (55%) and an MA in 34...
  39. Bonte D, Verduyn L, Braeckman B. Life history trade-offs imposed by dragline use in two money spiders. J Exp Biol. 2016;219:26-30 pubmed publisher
    ..of money spider at similar quantities to that under natural conditions and tested trade-offs with lifespan and egg sac production under unlimited prey availability and a dietary restriction treatment...
  40. Orion K, Najafian A, Ehlert B, Malas M, Black J, Abularrage C. Gender Predicts Rupture of Pancreaticoduodenal Artery Aneurysms. Ann Vasc Surg. 2016;36:1-6 pubmed publisher
    ..The primary outcome was technical success, defined as complete cessation of flow within the aneurysm sac on follow-up imaging. Secondary outcomes included complications greater than Clavien-Dindo Grade I...
  41. Exner M, Kuenzl T, To T, Ouyang Z, Schwagerus S, Hoesl M, et al. Design of S-Allylcysteine in Situ Production and Incorporation Based on a Novel Pyrrolysyl-tRNA Synthetase Variant. Chembiochem. 2017;18:85-90 pubmed publisher
    The noncanonical amino acid S-allyl cysteine (Sac) is one of the major compounds of garlic extract and exhibits a range of biological activities...
  42. Yamaguchi T, Imai M, Uematsu D. Hybrid approach using laparoscopy and transanal minimally invasive surgery to treat rectal cancer with invasion to the seminal vesicles. Asian J Endosc Surg. 2017;10:219-222 pubmed publisher
    ..The membranous peritoneum was dissected on both sides of the rectum to the cul de sac. The peritoneum was dissected anterolaterally to reveal the seminal ducts, which were ligated and dissected on both ..
  43. Ibrahim M, Ladan M, Abdussalam U, Getso K, Mohammad M, Chukwuemeka A, et al. Open inguinal herniotomy: Analysis of variations. Afr J Paediatr Surg. 2015;12:131-5 pubmed publisher
    ..This study was aimed at evaluating the efficacy of open herniotomy by comparing external ring incision, hernial sac twisting and whether or not double ligation has benefit over a single suture application...
  44. Antoniou G, Torella F, Harrison G, Neequaye S, McWilliams R, Fisher R. Aortic Dehiscence During Endovascular Sealing for Ruptured Abdominal Aortic Aneurysms. J Endovasc Ther. 2015;22:806-9 pubmed publisher
    ..revealed an increased retroperitoneal hematoma and pronounced disruption of the calcified rim of the aortic sac compared to the preoperative imaging. She was managed with supportive treatment, demonstrating remarkable progress...
  45. Li H, Zhu S, Zhang M, Wang T, Liang L, Xue Y, et al. Arabidopsis CBP1 Is a Novel Regulator of Transcription Initiation in Central Cell-Mediated Pollen Tube Guidance. Plant Cell. 2015;27:2880-93 pubmed publisher
    In flowering plants, sperm cells are delivered to the embryo sac by a pollen tube guided by female signals. Both the gametic and synergid cells contribute to pollen tube attraction...
  46. Cao M, Wu Y, Ashrafi G, McCartney A, Wheeler H, Bushong E, et al. Parkinson Sac Domain Mutation in Synaptojanin 1 Impairs Clathrin Uncoating at Synapses and Triggers Dystrophic Changes in Dopaminergic Axons. Neuron. 2017;93:882-896.e5 pubmed publisher
    ..While the role of SJ1's 5-phosphatase module in this process is well recognized, the contribution of its Sac phosphatase domain, whose preferred substrate is PI4P, remains unclear...
  47. Petersen S, Perkins A, Gibbons K, Bertolone J, Mahomed K. Utility of βhCG monitoring in the follow-up of medical management of miscarriage. Aust N Z J Obstet Gynaecol. 2017;57:358-365 pubmed publisher
    ..and after a planned seven day interval (follow-up), when a transvaginal ultrasound (TVUS) reported a gestational sac as present or not. If no sac at TVUS, surgery was indicated on clinical criteria...
  48. Chen K, Fustino N, Shukla A, Stroup E, Budhipramono A, Ateek C, et al. EGF Receptor and mTORC1 Are Novel Therapeutic Targets in Nonseminomatous Germ Cell Tumors. Mol Cancer Ther. 2018;17:1079-1089 pubmed publisher
    ..Here we show that nonseminomatous germ cell tumors (NSGCT, including embryonal carcinoma, yolk sac tumor, and choriocarcinoma) from both children and adults display activation of the mTORC1 pathway, while seminomas ..
  49. Lancrin C, Mazan M, Stefanska M, Patel R, Lichtinger M, Costa G, et al. GFI1 and GFI1B control the loss of endothelial identity of hemogenic endothelium during hematopoietic commitment. Blood. 2012;120:314-22 pubmed publisher
    ..Moreover, those cells are not released from the yolk sac and disseminated into embryonic tissues...
  50. Cığşar E, Karadag C, Dokucu A. Amyand's hernia: 11years of experience. J Pediatr Surg. 2016;51:1327-9 pubmed publisher
    Presence of the vermiform appendix in an inguinal hernia sac is known as Amyand's hernia. This may present as a tender inguinal swelling and is often misdiagnosed as irreducible or strangulated hernia...
  51. Nasr A. Vertebral level and measurements of conus medullaris and dural sac termination with special reference to the apex of the sacral hiatus: anatomical and magnetic resonance imaging radiologic study. Folia Morphol (Warsz). 2016;75:287-299 pubmed publisher
    Anatomical orientation of the caudal space and termination level of conus medullaris (CMT) and dural sac (DST) has great significance for anaesthetists and neurosurgeons...
  52. Zhang L, Liu X, Qin Z, Liu J, Zhang Z. Expression characteristics of sulfur dioxygenase and its function adaption to sulfide in echiuran worm Urechis unicinctus. Gene. 2016;593:334-41 pubmed publisher
    ..The SDO expressions at both mRNA and protein levels were highest in the anal sac, followed by the midgut, and were extraordinarily low in the body wall and hindgut; SDO was located mainly in the ..
  53. Rennert C, Eplinius F, Hofmann U, Johänning J, Rolfs F, Schmidt Heck W, et al. Conditional loss of hepatocellular Hedgehog signaling in female mice leads to the persistence of hepatic steroidogenesis, androgenization and infertility. Arch Toxicol. 2017;91:3677-3687 pubmed publisher
    ..In female SAC-KO mice, we detected androgenization characterized by a 3...
  54. Boos J, Brook O, Fang J, Temin N, Brook A, Raptopoulos V. What Is the Optimal Abdominal Aortic Aneurysm Sac Measurement on CT Images during Follow-up after Endovascular Repair?. Radiology. 2017;285:1032-1041 pubmed publisher
    ..and maximal diameter perpendicular to the reconstructed centerline; volume of the abdominal aortic aneurysm sac; and volume from the lowest renal artery to the aortic bifurcation and to the common iliac artery bifurcation were ..
  55. Kim Y, Kong Y, Lee J, Cheong Y, Kim S, Kim H, et al. Clinical symptoms of lumbar spinal stenosis associated with morphological parameters on magnetic resonance images. Eur Spine J. 2015;24:2236-43 pubmed publisher
    ..All patients underwent MRI of the L-spine and we measured the dural sac cross-sectional area (DSA), spinal canal cross-sectional area (SCA), ligamentum flavum cross-sectional area (LFA) ..
  56. Ow L, Walsh C, Rajamaheswari N, Dwyer P. Technique of extraperitoneal uterosacral ligament suspension for apical suspension. Int Urogynecol J. 2016;27:637-9 pubmed publisher
    ..With the extraperitoneal approach, the peritoneal sac, which can be difficult to access at times, especially when there are dense pelvic adhesions, does not need to be ..
  57. Hannan A, Malik M, Fasih S, Badar F, Siddiqui N. MALIGNANT OVARIAN GERM CELL TUMORS AT A TERTIARY CARE SETTING IN PAKISTAN. J Ayub Med Coll Abbottabad. 2015;27:624-7 pubmed
    ..Histologically, dysgerminoma was the most common diagnosis (22 patients) followed by teratoma in 16, yolk sac tumor in 15, mixed germ cell tumor in 12 while embryonal carcinoma was identified in only one patient...
  58. Liu X, Jin C, Wu L, Dong S, Zeng S, Li J. Isolation and characterization of a novel acidic matrix protein hic22 from the nacreous layer of the freshwater mussel, Hyriopsis cumingii. Genet Mol Res. 2016;15: pubmed publisher
    ..of the mantle pallial; moreover, significant expression levels of hic22 were observed after the early formation of the pearl sac (days 19-77), implying that hic22 may play an important role in biomineralization of the nacreous layer.
  59. Wathoni N, Motoyama K, Higashi T, Okajima M, Kaneko T, Arima H. Enhancing effect of ?-cyclodextrin on wound dressing properties of sacran hydrogel film. Int J Biol Macromol. 2017;94:181-186 pubmed publisher
    ..In this study, to enhance the wound-healing properties of sacran hydrogel film (Sac-HGF) further, we fabricated and characterized novel Sac-HGFs containing cyclodextrins (CyDs)...
  60. Quinn A, Mehta M, Teymouri M, Keenan M, Paty P, Zhou Y, et al. The incidence and fate of endoleaks vary between ruptured and elective endovascular abdominal aortic aneurysm repair. J Vasc Surg. 2017;65:1617-1624 pubmed publisher
    ..Persistent type II endoleaks at >6 months after EVAR without a decrease in AAA sac underwent translumbar or transfemoral embolization procedures...
  61. Chang C, Yeh T. Detection of 10 sweeteners in various foods by liquid chromatography/tandem mass spectrometry. J Food Drug Anal. 2014;22:318-328 pubmed publisher
    ..CYC), dulcin (DUL), glycyrrhizic acid (GA), neotame (NEO), neohesperidin dihydrochalcone (NHDC), saccharin (SAC), sucralose (SCL), and stevioside (STV)] in various foods by liquid chromatography/tandem mass chromatography (LC-..
  62. Marangos P, Stevense M, Niaka K, Lagoudaki M, Nabti I, Jessberger R, et al. DNA damage-induced metaphase I arrest is mediated by the spindle assembly checkpoint and maternal age. Nat Commun. 2015;6:8706 pubmed publisher
    ..The MI arrest is induced by the spindle assembly checkpoint (SAC) because inhibiting the SAC overrides the DNA damage-induced MI arrest...
  63. Park Y, Jung E, Byun J, An M, Kim Y, Lee K, et al. Laparoscopic total extraperitoneal hernia repair of fallopian tube indirect inguinal hernia in reproductive aged woman: a case report. Obstet Gynecol Sci. 2017;60:608-611 pubmed publisher
    ..We present a case of an indirect inguinal hernia containing only the fallopian tube in the hernia sac, which was successfully reduced by using a laparoscopic total extraperitoneal approach and repaired with a ..
  64. Peebles E, Barbosa T, Cummings T, Dickson J, Womack S. Comparative effects of in ovo versus subcutaneous administration of the Marek's disease vaccine and pre-placement holding time on the early post-hatch quality of Ross × Ross 708 broiler chicks. Poult Sci. 2016;95:2038-44 pubmed publisher
    ..At hatch and placement total and yolk-free BW; body length; body mass index; yolk sac weight; yolk-free body and yolk sac weights as percentages of total BW; and yolk-free body and yolk moisture ..
  65. Di Fiore B, Wurzenberger C, Davey N, Pines J. The Mitotic Checkpoint Complex Requires an Evolutionary Conserved Cassette to Bind and Inhibit Active APC/C. Mol Cell. 2016;64:1144-1153 pubmed publisher
    The Spindle Assembly Checkpoint (SAC) ensures genomic stability by preventing sister chromatid separation until all chromosomes are attached to the spindle...
  66. Abboud T, Rustom J, Bester M, Czorlich P, Vittorazzi E, Pinnschmidt H, et al. Morphology of Ruptured and Unruptured Intracranial Aneurysms. World Neurosurg. 2017;99:610-617 pubmed publisher
    ..Risk factors for rupture were identified. Morphology was classified into single-sac aneurysms with smooth margin, single-sac aneurysms with irregular margin, aneurysms with a daughter sac, and ..
  67. Mohebiany A, Waisman A. Upgrading from iMac to iMicro. Immunity. 2017;47:10-12 pubmed publisher
    ..These cells, which they call iMacs, are similar to yolk-sac-derived macrophages and are capable of undergoing terminal differentiation into tissue-resident-like macrophages in..
  68. Shea E, Ziegler A, Faber C, Shank T. Dumbo octopod hatchling provides insight into early cirrate life cycle. Curr Biol. 2018;28:R144-R145 pubmed publisher
    ..In addition, the presence of a large internal yolk sac reduces the risk of failure at first feeding...
  69. Vanni D, Galzio R, Kazakova A, Pantalone A, Sparvieri A, Salini V, et al. Intraforaminal ozone therapy and particular side effects: preliminary results and early warning. Acta Neurochir (Wien). 2016;158:491-6 pubmed publisher
    ..In particular, it was noted that the root contracted and had firm adhesions to the dural sac and/or fragmented disc, which were difficult to resolve...
  70. Oda M, Miyamoto I, Nishida I, Tanaka T, Kito S, Seta Y, et al. A spatial association between odontomas and the gubernaculum tracts. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;121:91-5 pubmed publisher
    ..to identify the spatial relationship and/or association between odontomas and the gubernaculum tract or the dental sac and the characteristic findings for radiographic diagnosis of odontomas...
  71. Patel C, Feldman J, Ogedegbe C. Complicated abdominal pregnancy with placenta feeding off sacral plexus and subsequent multiple ectopic pregnancies during a 4-year follow-up: a case report. J Med Case Rep. 2016;10:37 pubmed publisher
    ..She was found to have an intra-abdominal ectopic pregnancy with the placenta attached to her omentum, cul-de-sac and rectosigmoid, with unusual and extensive vascularity from the sacral plexus...
  72. Abuelo A, Hernández J, Alves Nores V, Benedito J, Castillo C. Association of Serum Concentration of Different Trace Elements with Biomarkers of Systemic Oxidant Status in Dairy Cattle. Biol Trace Elem Res. 2016;174:319-324 pubmed
    ..Sr, V and Zn) and markers of oxidant status (reactive oxygen species (ROS) and total serum antioxidant capacity (SAC)). The Oxidative Stress index (OSi) was also calculated as ROS/SAC...
  73. Qian Z, Feng X, Kang H, Wen X, Xu W, Zhao F, et al. Ruptured Wide-Necked Aneurysms: Is Stent-Assisted Coiling During Posthemorrhage Days 4-10 Safe and Efficient?. World Neurosurg. 2017;101:137-143 pubmed publisher
    Recent studies have reported the use of stent-assisted coiling (SAC) for wide-necked aneurysms in patients with acute subarachnoid hemorrhage (SAH)...
  74. Yost S, de Wolf B, Hanks S, Zachariou A, Marcozzi C, Clarke M, et al. Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation. Nat Genet. 2017;49:1148-1151 pubmed publisher
    ..patient cells have no detectable TRIP13 and have substantial impairment of the spindle assembly checkpoint (SAC), leading to a high rate of chromosome missegregation...
  75. Little D, Bullimore B, Galperin Y, Langston W. Sediment contaminant surveillance in Milford Haven Waterway. Environ Monit Assess. 2016;188:34 pubmed publisher
    ..their MHW data for 2007 and 2012, collected to assess the condition of the Special Area of Conservation (SAC) designated under the European Union Habitats Directive. Datasets during 2007-2012 have thus been more comparable...
  76. Ou C, Huang W, Yuen M. A computational model based on fibrin accumulation for the prediction of stasis thrombosis following flow-diverting treatment in cerebral aneurysms. Med Biol Eng Comput. 2017;55:89-99 pubmed publisher
    ..Thrombus was predicted to form inside the sac, and the aneurysm was occluded with only a small remnant neck remained...
  77. Neviere R, Delguste F, Durand A, Inamo J, Boulanger E, Preau S. Abnormal Mitochondrial cAMP/PKA Signaling Is Involved in Sepsis-Induced Mitochondrial and Myocardial Dysfunction. Int J Mol Sci. 2016;17: pubmed
    ..Mitochondrial cAMP-PKA signaling is impaired in the septic myocardium. PDE2 phosphodiesterase inhibition by BAY60-7550 improves mitochondrial respiration and cardiac MVO? efficiency in septic mice. ..
  78. To J, Hanna P, Mohammed R, Trinh S, Vazquez F, Zuberi J, et al. Amyand's hernia presenting as an unusual inguinal mass: a case report. Ann Transl Med. 2017;5:346 pubmed publisher
    ..inguinal hernias, Amyand's hernia is a rare condition in which a vermiform appendix is found in an inguinal hernia sac. It is most commonly found in males and in the pediatric population...
  79. Lanaud C, Fouet O, Legavre T, Lopes U, Sounigo O, Eyango M, et al. Deciphering the Theobroma cacao self-incompatibility system: from genomics to diagnostic markers for self-compatibility. J Exp Bot. 2017;68:4775-4790 pubmed publisher
    ..been described as being controlled by a late gameto-sporophytic system expressed only at the level of the embryo sac. It results in gametic non-fusion and involves several loci...
  80. Zanoletti E, Girasoli L, Borsetto D, Opocher G, Mazzoni A, Martini A. Endolymphatic sac tumour in von Hippel-Lindau disease: management strategies. Acta Otorhinolaryngol Ital. 2017;37:423-429 pubmed publisher
    Endolymphatic sac tumour (ELST) is infrequent, as emerges from small series reported in the literature. It is a slow-growing malignancy with local aggressiveness and a low risk of distant metastases...
  81. Dağdeviren Çakır A, Turan H, Aykut A, Durmaz A, Ercan O, Evliyaoglu O. Two childhood pheochromocytoma cases due to von Hippel -Lindau disease, one associated with pancreatic neuroendocrine tumor; a rare manifestation. J Clin Res Pediatr Endocrinol. 2017;: pubmed publisher
    ..hemangioblastomas of retina and central nervous system (CNS); renal cysts, clear cell carcinoma; PCC; endolymphatic sac tumors; cystadenomas of the epididymis in males, broad ligament of uterus in females; pancreatic cysts, ..
  82. Komaki S, Schnittger A. The Spindle Assembly Checkpoint in Arabidopsis Is Rapidly Shut Off during Severe Stress. Dev Cell. 2017;43:172-185.e5 pubmed publisher
    The spindle assembly checkpoint (SAC) in animals and yeast assures equal segregation of chromosomes during cell division...
  83. Middelhaufe S, Leipelt M, Levin L, Buck J, Steegborn C. Identification of a haem domain in human soluble adenylate cyclase. Biosci Rep. 2012;32:491-9 pubmed publisher
    ..activator NO (nitric oxide), very little is known about the regulatory domains of the ubiquitous signalling enzyme sAC (soluble AC). In the present study, we identify a unique type of HD as a regulatory domain in sAC...
  84. Colli Franzone P, Pavarino L, Scacchi S. Effects of mechanical feedback on the stability of cardiac scroll waves: A bidomain electro-mechanical simulation study. Chaos. 2017;27:093905 pubmed publisher
    ..PLoS One 8(4), e60287 (2013)] that were based on the Monodomain model and a simple non-selective linear SAC, while here we consider the full Bidomain model and both selective and non-selective components of SACs...
  85. Barber S, Boghani Z, Steele W, Blacklock J, Trask T, Holman P. Variation in Psoas Muscle Location Relative to the Safe Working Zone for L4/5 Lateral Transpsoas Interbody Fusion: A Morphometric Analysis. World Neurosurg. 2017;107:396-399 pubmed publisher
    ..The AP distance between the ventral aspect of the thecal sac and the dorsal aspect of the psoas muscle at L4/5 was measured, as was the AP diameter of the L4/5 disc space...
  86. Zhang S, He J, Niu T, Liu S, Chan C, Ren C, et al. Effectiveness of meibomian gland massage combined with topical levofloxacin against ocular surface flora in patients before penetrating ocular surgery. Ocul Surf. 2018;16:70-76 pubmed publisher
    ..Samples from the conjunctival sac and meibomian glands were collected for aerobic and anaerobic cultures. Culture-positivity and bacterial strains...
  87. Gloekler S, Hajredini B, Rycerz S, Jäckle S, Jung W. [Left atrial appendage clusure in nonvalvular atrial fibrillation : Clinical evidence 2017]. Herzschrittmacherther Elektrophysiol. 2017;28:366-380 pubmed publisher
    ..Thrombi form almost exclusively in the left atrial appendage (LAA), a blind sac-like heterogeneous structure trabeculated by pectinate muscles...
  88. Marie P, Plissonnier D, Bravetti S, Coscas R, Rouer M, Haulon S, et al. Low baseline and subsequent higher aortic abdominal aneurysm FDG uptake are associated with poor sac shrinkage post endovascular repair. Eur J Nucl Med Mol Imaging. 2018;45:549-557 pubmed publisher
    ..serial AAA FDG uptake measurements, obtained before EVAR and 1 and 6 months post-intervention and subsequent sac shrinkage at 6 months, a well-recognized indicator of successful repair...
  89. Amos P, Fung S, Case A, Kifelew J, Osnis L, Smith C, et al. Modulation of Hematopoietic Lineage Specification Impacts TREM2 Expression in Microglia-Like Cells Derived From Human Stem Cells. ASN Neuro. 2017;9:1759091417716610 pubmed publisher
    ..Our approach is based on recent studies demonstrating that microglia originate from primitive yolk sac mesoderm distinct from peripheral macrophages that arise during definitive hematopoiesis...
  90. Kim J, Bae S, Lee H, Park J, Kim K. Claudin5a is required for proper inflation of Kupffer's vesicle lumen and organ laterality. PLoS ONE. 2017;12:e0182047 pubmed publisher
    ..In zebrafish, the Kupffer's vesicle (KV) is a fluid-filled sac which controls asymmetric organ development, and a properly inflated KV lumen by means of fluid influx is a ..
  91. Lee M, Khwarg S, Kim I, Choi J, Choi Y, Kim N, et al. Intraoperatively Observed Lacrimal Obstructive Features and Surgical Outcomes in External Dacryocystorhinostomy. Korean J Ophthalmol. 2017;31:383-387 pubmed publisher
    ..Lacrimal sac mucosa and lumen were grossly inspected, and the frequency of lacrimal sac changes, such as significant ..
  92. Levitt M, Barbour M, Rolland du Roscoat S, Geindreau C, Chivukula V, McGah P, et al. Computational fluid dynamics of cerebral aneurysm coiling using high-resolution and high-energy synchrotron X-ray microtomography: comparison with the homogeneous porous medium approach. J Neurointerv Surg. 2017;9: pubmed publisher
    ..simplifies the complex geometry of the coil mass into a homogeneous porous medium that fills the aneurysmal sac. We compare hemodynamics of coiled aneurysms modeled from high-resolution imaging with those from the same ..