Gene Symbol: ADAMTS9
Description: ADAM metallopeptidase with thrombospondin type 1 motif 9
Alias: A disintegrin and metalloproteinase with thrombospondin motifs 9, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 9
Species: human
Products:     ADAMTS9

Top Publications

  1. Clark M, Kelner G, Turbeville L, Boyer A, Arden K, Maki R. ADAMTS9, a novel member of the ADAM-TS/ metallospondin gene family. Genomics. 2000;67:343-50 pubmed
    ..We have cloned a new member of the ADAM-TS/metallospondin family designated here as ADAMTS9. This protein has a metalloprotease domain, a disintegrin-like domain, one internal TSP1 motif, and three carboxy-..
  2. Koo B, Longpre J, Somerville R, Alexander J, Leduc R, Apte S. Cell-surface processing of pro-ADAMTS9 by furin. J Biol Chem. 2006;281:12485-94 pubmed
    ..Here, we show in a variety of cell types that the propeptide of ADAMTS9 is not excised intracellularly...
  3. Stancakova A, Kuulasmaa T, Paananen J, Jackson A, Bonnycastle L, Collins F, et al. Association of 18 confirmed susceptibility loci for type 2 diabetes with indices of insulin release, proinsulin conversion, and insulin sensitivity in 5,327 nondiabetic Finnish men. Diabetes. 2009;58:2129-36 pubmed publisher
    ..KCNJ11, TCF7L2, SLC30A8, HHEX, LOC387761, CDKN2B, IGF2BP2, CDKAL1, HNF1B, WFS1, JAZF1, CDC123, TSPAN8, THADA, ADAMTS9, NOTCH2, KCNQ1, and MTNR1B were performed...
  4. Sanghera D, Been L, Ortega L, Wander G, Mehra N, Aston C, et al. Testing the association of novel meta-analysis-derived diabetes risk genes with type II diabetes and related metabolic traits in Asian Indian Sikhs. J Hum Genet. 2009;54:162-8 pubmed publisher
    A recent meta-analysis on three genome-wide association (GWA) scans identified six loci (NOTCH2, THADA, ADAMTS9, JAZF1, CDC123/CAMKID and TSPAN8/LGRS) highly associated with type II diabetes (T2D) in Caucasians...
  5. Lango H, Palmer C, Morris A, Zeggini E, Hattersley A, McCarthy M, et al. Assessing the combined impact of 18 common genetic variants of modest effect sizes on type 2 diabetes risk. Diabetes. 2008;57:3129-35 pubmed publisher
    ..Further studies are needed to assess whether individuals with extreme numbers of risk alleles may benefit from genetic testing. ..
  6. Staiger H, Machicao F, Kantartzis K, Schäfer S, Kirchhoff K, Guthoff M, et al. Novel meta-analysis-derived type 2 diabetes risk loci do not determine prediabetic phenotypes. PLoS ONE. 2008;3:e3019 pubmed publisher
    ..nucleotide polymorphisms (SNPs) JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8/LGR5 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs10923931, DCD rs1153188, VEGFA rs9472138, and BCL11A rs10490072...
  7. Meigs J, Shrader P, Sullivan L, McAteer J, Fox C, Dupuis J, et al. Genotype score in addition to common risk factors for prediction of type 2 diabetes. N Engl J Med. 2008;359:2208-19 pubmed publisher
    ..A genotype score based on 18 risk alleles predicted new cases of diabetes in the community but provided only a slightly better prediction of risk than knowledge of common risk factors alone. ..
  8. Lyssenko V, Jonsson A, Almgren P, Pulizzi N, Isomaa B, Tuomi T, et al. Clinical risk factors, DNA variants, and the development of type 2 diabetes. N Engl J Med. 2008;359:2220-32 pubmed publisher
    ..The value of genetic factors increased with an increasing duration of follow-up. ..
  9. Heid I, Jackson A, Randall J, Winkler T, Qi L, Steinthorsdottir V, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010;42:949-60 pubmed publisher
    ..identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10⁻⁹ to P = 1...

More Information


  1. Zeggini E, Scott L, Saxena R, Voight B, Marchini J, Hu T, et al. Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes. Nat Genet. 2008;40:638-45 pubmed publisher
    ..0 x 10(-14)), CDC123-CAMK1D (P = 1.2 x 10(-10)), TSPAN8-LGR5 (P = 1.1 x 10(-9)), THADA (P = 1.1 x 10(-9)), ADAMTS9 (P = 1.2 x 10(-8)) and NOTCH2 (P = 4.1 x 10(-8)) gene regions...
  2. Lin X, Song K, Lim N, Yuan X, Johnson T, Abderrahmani A, et al. Risk prediction of prevalent diabetes in a Swiss population using a weighted genetic score--the CoLaus Study. Diabetologia. 2009;52:600-8 pubmed publisher
    ..In this population, a simple weighted 15 SNP-based genetic score provides additional information over clinical predictors of prevalent diabetes. At this stage, however, the clinical benefit of this genetic information is limited. ..
  3. Grarup N, Andersen G, Krarup N, Albrechtsen A, Schmitz O, Jørgensen T, et al. Association testing of novel type 2 diabetes risk alleles in the JAZF1, CDC123/CAMK1D, TSPAN8, THADA, ADAMTS9, and NOTCH2 loci with insulin release, insulin sensitivity, and obesity in a population-based sample of 4,516 glucose-tolerant middle-aged D. Diabetes. 2008;57:2534-40 pubmed publisher
    ..variants in the JAZF1 (rs864745), CDC123/CAMK1D (rs12779790), TSPAN8 (rs7961581), THADA (rs7578597), ADAMTS9 (rs4607103), and NOTCH2 (rs10923931) loci, which were recently identified by meta-analysis of genome-wide ..
  4. van Hoek M, Dehghan A, Witteman J, van Duijn C, Uitterlinden A, Oostra B, et al. Predicting type 2 diabetes based on polymorphisms from genome-wide association studies: a population-based study. Diabetes. 2008;57:3122-8 pubmed publisher
    ..Of the 18 polymorphisms, the ADAMTS9, CDKAL1, CDKN2A/B-rs1412829, FTO, IGF2BP2, JAZF1, SLC30A8, TCF7L2, and WFS1 variants were associated with type 2 ..
  5. Somerville R, Longpre J, Jungers K, Engle J, Ross M, Evanko S, et al. Characterization of ADAMTS-9 and ADAMTS-20 as a distinct ADAMTS subfamily related to Caenorhabditis elegans GON-1. J Biol Chem. 2003;278:9503-13 pubmed
    ..However, ADAMTS9 is highly expressed in embryonic and adult tissues, and therefore we characterized the ADAMTS-9 protein further...
  6. Li S, Li T, Li X, Yao Y, Jiang X, Zhao L, et al. MicroRNA-32 Regulates Development and Progression of Hepatocellular Carcinoma by Targeting ADAMTS9 and Affects Its Prognosis. Med Sci Monit Basic Res. 2018;24:177-187 pubmed publisher
    ..and its clinical pathological significance, as well as to determine the functional connection between miR-32 and ADAMTS9 in HCC...
  7. Dubail J, Apte S. Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics. Matrix Biol. 2015;44-46:24-37 pubmed publisher
    ..Genome-wide analyses have determined an association of some ADAMTS loci such as ADAMTS9 and ADAMTS7, with specific traits and acquired disorders...
  8. Thio C, Reznichenko A, van der Most P, Kamali Z, Vaez A, Smit J, et al. Genome-Wide Association Scan of Serum Urea in European Populations Identifies Two Novel Loci. Am J Nephrol. 2019;49:193-202 pubmed publisher
    ..significant single nucleotide polymorphisms (SNPs) in or near 6 loci, of which 2 were novel (POU2AF1 and ADAMTS9-AS2). Replication of East-Asian and Scottish data provided evidence for an additional 8 loci...
  9. Sun M, Wu D, Zhou K, Li H, Gong X, Wei Q, et al. An eight-lncRNA signature predicts survival of breast cancer patients: a comprehensive study based on weighted gene co-expression network analysis and competing endogenous RNA network. Breast Cancer Res Treat. 2019;: pubmed publisher
    ..105 × EXPC10orf126) + (0.065 × EXPWT1-AS) + (- 0.126 × EXPADAMTS9-AS1) + (- 0.130 × EXPSRGAP3-AS2) + (0.116 × EXPTLR8-AS1) + (0...
  10. Ayanoğlu T, Atalar H, Esen E, Ataoglu M, Turanli S, Demircan K. The role of ADAMTS genes in the end stage of hip osteoarthritis. Acta Orthop Traumatol Turc. 2019;: pubmed publisher
    ..The level of ADAMTS5 and ADAMTS9 genes were found significantly lower as a result of ELISA analysis degenerative arthritis group than the control ..
  11. Chen L, Wang H, Zhang Y, Chen Q, Lin T, Liu Z, et al. Robust analysis of novel mRNA-lncRNA cross talk based on ceRNA hypothesis uncovers carcinogenic mechanism and promotes diagnostic accuracy in esophageal cancer. Cancer Manag Res. 2019;11:347-358 pubmed publisher
    ..We successfully constructed an oncogenic ceRNet of EC, crosstalk of hsa-miR372-centered CADM2-ADAMTS9-AS2 and hsa-miR145-centered SERPINE1-PVT1. In addition, the risk-score model -0...
  12. Choi Y, Halbritter J, Braun D, Schueler M, Schapiro D, Rim J, et al. Mutations of ADAMTS9 Cause Nephronophthisis-Related Ciliopathy. Am J Hum Genet. 2019;104:45-54 pubmed publisher
    ..We identified two ADAMTS9 mutations (c.4575_4576del [p.Gln1525Hisfs60] and c.194C>G [p...
  13. Graae A, Grarup N, Ribel Madsen R, Lystbæk S, Boesgaard T, Staiger H, et al. ADAMTS9 Regulates Skeletal Muscle Insulin Sensitivity Through Extracellular Matrix Alterations. Diabetes. 2019;68:502-514 pubmed publisher
    The ADAMTS9 rs4607103 C allele is one of the few gene variants proposed to increase the risk of type 2 diabetes through an impairment of insulin sensitivity...
  14. García Faroldi G, Rönnberg E, Grujic M, Pejler G. Inhibition of the BET family of epigenetic reader proteins: A novel principle for modulating gene expression in IgE-activated mast cells. Immun Inflamm Dis. 2017;5:141-150 pubmed publisher
    ..additional genes of those that were upregulated by IgE receptor cross-linking, including IL-3, IL-7R, CCR1, and ADAMTS9. However, BET inhibition was selective, i.e...
  15. Franceschini N, Giambartolomei C, de Vries P, Finan C, Bis J, Huntley R, et al. GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes. Nat Commun. 2018;9:5141 pubmed publisher
    ..metabolic tissues obtained from patients with CHD identifies candidate genes at two potentially additional loci, ADAMTS9 and LOXL4...
  16. Fan C, Ma L, Liu N. Systematic analysis of lncRNA-miRNA-mRNA competing endogenous RNA network identifies four-lncRNA signature as a prognostic biomarker for breast cancer. J Transl Med. 2018;16:264 pubmed publisher
    ..A univariate regression analysis of the DElncRNAs revealed 7 lncRNAs (ADAMTS9-AS1, AC061992.1, LINC00536, HOTAIR, AL391421...
  17. Hoffmann C, Harms U, Rex A, Szulzewsky F, Wolf S, Grittner U, et al. Vascular signal transducer and activator of transcription-3 promotes angiogenesis and neuroplasticity long-term after stroke. Circulation. 2015;131:1772-82 pubmed publisher
    ..toward an antiangiogenic and axon growth-inhibiting micromilieu after stroke, with an increased expression of Adamts9. Remodeling and glycosylation of the extracellular matrix and microglia proliferation were increased, whereas ..
  18. Wang A, Jin C, Li H, Qin Q, Li L. LncRNA ADAMTS9-AS2 regulates ovarian cancer progression by targeting miR-182-5p/FOXF2 signaling pathway. Int J Biol Macromol. 2018;120:1705-1713 pubmed publisher
    ..However, the roles and underlying mechanisms of ADAMTS9-AS2 in OC remain unclear...
  19. Ozler S, Isci Bostanci E, Oztas E, Kuru Pekcan M, Gümüş Güler B, Yilmaz N. The role of ADAMTS4 and ADAMTS9 in cardiovascular disease in premature ovarian insufficiency and idiopathic hypogonadotropic hypogonadism. J Endocrinol Invest. 2018;41:1477-1483 pubmed publisher
    ..with thrombospondin motifs-4 (ADAMTS4), and a disintegrin and metalloproteinase with thrombospondin motifs-9 (ADAMTS9) with cardiovascular disease (CVD) risk, in ovarian dysfunction patients with premature ovarian insufficiency (..
  20. Benz B, Nandadasa S, Takeuchi M, Grady R, Takeuchi H, LoPilato R, et al. Genetic and biochemical evidence that gastrulation defects in Pofut2 mutants result from defects in ADAMTS9 secretion. Dev Biol. 2016;416:111-122 pubmed publisher
    ..Both the mouse Pofut2 RST434 gene trap allele and the Adamts9 knockout were reported to result in early embryonic lethality, suggesting that defects in Pofut2 mutant embryos ..
  21. Regassa A, Kim W. Transcriptome analysis of hen preadipocytes treated with an adipogenic cocktail (DMIOA) with or without 20(S)-hydroxylcholesterol. BMC Genomics. 2015;16:91 pubmed publisher
    ..Genes over-expressed in DMIOA compared to control cells include those involved in cellular development (ADAM22, ADAMTS9, FIGF), lipid metabolism (FABP3, 4 and 5), and molecular transport (MAP3K8, PDK4, AGTR1)...
  22. Xie S, Yu X, Li Y, Ma H, Fan S, Chen W, et al. Upregulation of lncRNA ADAMTS9-AS2 Promotes Salivary Adenoid Cystic Carcinoma Metastasis via PI3K/Akt and MEK/Erk Signaling. Mol Ther. 2018;26:2766-2778 pubmed publisher
    ..In our study, we found that ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9) antisense RNA 2 (ADAMTS9-AS2) was significantly upregulated in SACC patients with metastasis and SACC-lung ..
  23. Gök K, Cemeroglu O, Cakirbay H, Gunduz E, Acar M, Cetin E, et al. Relationship between cytosine-adenine repeat polymorphism of ADAMTS9 gene and clinical and radiologic severity of knee osteoarthritis. Int J Rheum Dis. 2018;21:821-827 pubmed publisher
    The aim of this study is to determine the role of cytosine-adenine (CA) micro-satellite repeat sequence of ADAMTS9 gene on the development and progression of osteoarthritis (OA)...
  24. Cao B, Liu C, Yang G. Down-regulation of lncRNA ADAMTS9-AS2 contributes to gastric cancer development via activation of PI3K/Akt pathway. Biomed Pharmacother. 2018;107:185-193 pubmed publisher
    We aimed to investigate the role and regulatory mechanism of lncRNA ADAMTS9-AS2 in the development of gastric cancer. The expression of lncRNA ADAMTS9-AS2 in gastric cancer tissues and cells was detected...
  25. Padang R, Bagnall R, Tsoutsman T, Bannon P, Semsarian C. Comparative transcriptome profiling in human bicuspid aortic valve disease using RNA sequencing. Physiol Genomics. 2015;47:75-87 pubmed publisher
    ..Downregulation of matrix protease ADAMTS9 and protein aggrecan were observed in BAVr compared with TAV...
  26. Rosewell K, Al Alem L, Zakerkish F, McCord L, Akin J, Chaffin C, et al. Induction of proteinases in the human preovulatory follicle of the menstrual cycle by human chorionic gonadotropin. Fertil Steril. 2015;103:826-33 pubmed publisher
    ..ADAMTS1 and ADAMTS9 mRNA increased in granulosa cells after hCG treatment, however, thecal cell expression for ADAMTS1 was unchanged, ..
  27. Mead T, Du Y, Nelson C, Gueye N, Drazba J, Dancevic C, et al. ADAMTS9-Regulated Pericellular Matrix Dynamics Governs Focal Adhesion-Dependent Smooth Muscle Differentiation. Cell Rep. 2018;23:485-498 pubmed publisher
    ..Using conditional deletion in mice, we show that ADAMTS9, a secreted metalloprotease, is required for myometrial activation during late gestation and for parturition...
  28. de Jong E, Breukink M, Schellevis R, Bakker B, Mohr J, Fauser S, et al. Chronic central serous chorioretinopathy is associated with genetic variants implicated in age-related macular degeneration. Ophthalmology. 2015;122:562-70 pubmed publisher
    ..002; odds ratio [OR]=0.64). The SNPs at 3 other AMD loci (CFH, TNFRSF10A, ADAMTS9) showed a trend toward association with typical cCSC...
  29. Liu C, Buchkovich M, Winkler T, Heid I, Borecki I, Fox C, et al. Multi-ethnic fine-mapping of 14 central adiposity loci. Hum Mol Genet. 2014;23:4738-44 pubmed publisher
    ..1). Trans-ethnic analyses at five loci (TBX15-WARS2, LYPLAL1, ADAMTS9, LY86 and ITPR2-SSPN) substantially narrowed the signals to smaller sets of variants, some of which are in ..
  30. Desanlis I, Felstead H, Edwards D, Wheeler G. ADAMTS9, a member of the ADAMTS family, in Xenopus development. Gene Expr Patterns. 2018;29:72-81 pubmed publisher
    ..of the entire ADAMTS family was studied from early stages to tadpole stages of Xenopus, and detailed analysis of ADAMTS9 revealed expression in many structures during organogenesis such as neural crest (NC) derivative tissues, the ..
  31. Pan W, Kile M, Seow W, Lin X, Quamruzzaman Q, Rahman M, et al. Genetic susceptible locus in NOTCH2 interacts with arsenic in drinking water on risk of type 2 diabetes. PLoS ONE. 2013;8:e70792 pubmed publisher
    ..6 µg/L vs. 12.5 µg/L, p-value <0.001). Three SNPs in ADAMTS9 were nominally associated with increased risk of T2DM (rs17070905, Odds Ratio (OR) ?=?2...
  32. Karakose M, Demircan K, Tutal E, Demirci T, Arslan M, Sahin M, et al. Clinical significance of ADAMTS1, ADAMTS5, ADAMTS9 aggrecanases and IL-17A, IL-23, IL-33 cytokines in polycystic ovary syndrome. J Endocrinol Invest. 2016;39:1269-1275 pubmed
    ..The aim of this investigation was to evaluate the serum levels of ADAMTS1, ADAMTS5, ADAMTS9, IL-17, IL-23, IL-33 and to find out the relationship between these inflammatory cytokines and ADAMTSs in PCOS ..
  33. Steele M, Luna L, Coldren C, Murphy E, Hennessy C, Heinz D, et al. Relationship between gene expression and lung function in Idiopathic Interstitial Pneumonias. BMC Genomics. 2015;16:869 pubmed publisher
    ..with mild vs severe disease (categorical analysis), including those with established role in fibrosis (ADAMTS4, ADAMTS9, AGER, HIF-1α, SERPINA3, SERPINE2, and SELE) as well as novel IIP candidate genes such as rhotekin 2 (RTKN2) ..
  34. Nandadasa S, Nelson C, Apte S. ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation. Cell Rep. 2015;11:1519-28 pubmed publisher
    ..Here, the secreted metalloprotease ADAMTS9 is shown to be necessary for murine umbilical cord vascular development...
  35. Gäbel G, Northoff B, Weinzierl I, Ludwig S, Hinterseher I, Wilfert W, et al. Molecular Fingerprint for Terminal Abdominal Aortic Aneurysm Disease. J Am Heart Assoc. 2017;6: pubmed publisher
    ..i>LOX, SRPX2, FCGBP), and a second set containing 5 genes exclusively upregulated in rAAA (ADAMTS9, STC1, GFPT2, GAL3ST4, CCL4L1)...
  36. Gaucherand L, Falk B, Evanko S, Workman G, Chan C, Wight T. Crosstalk Between T Lymphocytes and Lung Fibroblasts: Generation of a Hyaluronan-Enriched Extracellular Matrix Adhesive for Monocytes. J Cell Biochem. 2017;118:2118-2130 pubmed publisher
    ..of mRNA for versican, and increased the expression of enzymes that degrade versican, such as ADAMTS4 and ADAMTS9 (a disintegrin and metalloproteinase with a thrombospondin type-1 motif) leading to a decrease in versican in the ..
  37. Lussier J, Diouf M, Lévesque V, Sirois J, Ndiaye K. Gene expression profiling of upregulated mRNAs in granulosa cells of bovine ovulatory follicles following stimulation with hCG. Reprod Biol Endocrinol. 2017;15:88 pubmed publisher
    ..of the respective mRNAs in GC of OF 24 h after hCG-injection compared with those of DF for the following genes: ADAMTS9, ARAF, CAPN2, CRISPLD2, FKBP5, GFPT2, KIT, KITLG, L3MBLT3, MRO, NUDT10, NUDT11, P4HA3, POSTN, PSAP, RBP1, SAT1, ..
  38. Dubail J, Vasudevan D, Wang L, Earp S, Jenkins M, Haltiwanger R, et al. Impaired ADAMTS9 secretion: A potential mechanism for eye defects in Peters Plus Syndrome. Sci Rep. 2016;6:33974 pubmed publisher
    ..We report here that haploinsufficiency of murine Adamts9, encoding a secreted metalloproteinase with 15 TSRs, leads to congenital corneal opacity and Peters anomaly (..
  39. Rivollier F, Chaumette B, Bendjemaa N, Chayet M, Millet B, Jaafari N, et al. Methylomic changes in individuals with psychosis, prenatally exposed to endocrine disrupting compounds: Lessons from diethylstilbestrol. PLoS ONE. 2017;12:e0174783 pubmed publisher
    ..The largest difference was in a region near the promoter of an ADAMTS proteoglycanase gene (ADAMTS9)...
  40. Walsh S, Pośpiech E, Branicki W. Hot on the Trail of Genes that Shape Our Fingerprints. J Invest Dermatol. 2016;136:740-742 pubmed publisher
    ..Furthermore, they propose that one highly associated gene, ADAMTS9-AS2, has a role in epigenetic regulation, a role that may be important in early-stage digit development.
  41. Trombetta M, Bonetti S, Boselli M, Miccoli R, Trabetti E, Malerba G, et al. PPARG2 Pro12Ala and ADAMTS9 rs4607103 as "insulin resistance loci" and "insulin secretion loci" in Italian individuals. The GENFIEV study and the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 4. Acta Diabetol. 2013;50:401-8 pubmed publisher
    ..cross-sectionally whether the type 2 diabetes (T2DM) risk alleles of rs1801282 (PPARG2) and rs4607103 (ADAMTS9) were associated with T2DM and/or insulin sensitivity (IS) and beta cell function (βF) in Italians without and ..
  42. Yoshina S, Mitani S. Loss of C. elegans GON-1, an ADAMTS9 Homolog, Decreases Secretion Resulting in Altered Lifespan and Dauer Formation. PLoS ONE. 2015;10:e0133966 pubmed publisher
    b>ADAMTS9 is a metalloprotease that cleaves components of the extracellular matrix and is also implicated in transport from the endoplasmic reticulum (ER) to the Golgi...
  43. Wang H, Fu Z, Dai C, Cao J, Liu X, Xu J, et al. LncRNAs expression profiling in normal ovary, benign ovarian cyst and malignant epithelial ovarian cancer. Sci Rep. 2016;6:38983 pubmed publisher
    ..We also determined that two antisense lncRNAs (RP11-597D13.9 and ADAMTS9-AS1) were associated with their nearby coding genes (FAM198B, ADAMTS9), which participated in cancer progression...
  44. Lango Allen H, Johansson S, Ellard S, Shields B, Hertel J, Raeder H, et al. Polygenic risk variants for type 2 diabetes susceptibility modify age at diagnosis in monogenic HNF1A diabetes. Diabetes. 2010;59:266-71 pubmed publisher
    ..This is one of the first studies to demonstrate that clinical characteristics of a monogenic disease can be modified by common polygenic variants. ..
  45. Kang E, Kim M, Kim C, Nam C, Han S, Hur K, et al. Association of common type 2 diabetes risk gene variants and posttransplantation diabetes mellitus in renal allograft recipients in Korea. Transplantation. 2009;88:693-8 pubmed publisher
    ..FTO rs8050136, WFS1 rs734312, JAZF1 rs864745, CDC123/CAMK1D rs12779790, TSPAN8 rs7961581, THADA rs7578597, ADAMTS9 rs4607103, NOTCH2 rs1092391, and KCNQ1 rs2237892...
  46. Schleinitz D, Tonjes A, Bottcher Y, Dietrich K, Enigk B, Koriath M, et al. Lack of significant effects of the type 2 diabetes susceptibility loci JAZF1, CDC123/CAMK1D, NOTCH2, ADAMTS9, THADA, and TSPAN8/LGR5 on diabetes and quantitative metabolic traits. Horm Metab Res. 2010;42:14-22 pubmed publisher
    ..We performed an association study of 9 SNPs in or around JAZF1, CDC123/ CAMK1D, NOTCH2, BCL11A, ADAMTS9, VEGFA, DCD, THADA, and TSPAN8/ LGR5 with T2D and related quantitative traits (fasting insulin and glucose, ..
  47. Fan Q, Cheung C, Chen L, Yamashiro K, Ahn J, Laude A, et al. Shared genetic variants for polypoidal choroidal vasculopathy and typical neovascular age-related macular degeneration in East Asians. J Hum Genet. 2017;62:1049-1055 pubmed publisher
    ..susceptibility 2 (ARMS2)-HtrA serine peptidase 1 (HTRA1), complement factor H (CFH), C2-CFB-SKIV2L, CETP, VEGFA, ADAMTS9-AS2 and TGFBR1 (P<5 × 10-4) from the single-nucleotide polymorphism-based test and COL4A3 from the ..
  48. Mahajan G, Vallender E, Garrett M, Challagundla L, Overholser J, Jurjus G, et al. Altered neuro-inflammatory gene expression in hippocampus in major depressive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2018;82:177-186 pubmed publisher
    ..while up-regulated genes included several with cytokine function (CCL2/MCP-1), inhibitors of angiogenesis (ADM, ADAMTS9), and the KANSL1 gene, a histone acetyltransferase...
  49. Bolte C, Flood H, Ren X, Jagannathan S, Barski A, Kalin T, et al. FOXF1 transcription factor promotes lung regeneration after partial pneumonectomy. Sci Rep. 2017;7:10690 pubmed publisher
    ..altered expression of numerous genes including those regulating extracellular matrix remodeling (Timp3, Adamts9) and cell cycle progression (Cdkn1a, Cdkn2b, Cenpj, Tubb4a), which are critical for lung regeneration...
  50. Karaköse M, Caliskan M, Arslan M, Demirci T, Karakose S, Tutal E, et al. Association of ADAMTS4 and ADAMTS9 levels with cardiovascular risk in patients with primary hyperparathyroidism. Endocr Res. 2018;43:15-20 pubmed publisher
    ..This study aimed to investigate the levels of ADAMTS4 and ADAMTS9 and relationship between these proteoglycanases and cardiometabolic abnormalities in PHPT...
  51. Lung H, Lo P, Xie D, Apte S, Cheung A, Cheng Y, et al. Characterization of a novel epigenetically-silenced, growth-suppressive gene, ADAMTS9, and its association with lymph node metastases in nasopharyngeal carcinoma. Int J Cancer. 2008;123:401-408 pubmed publisher
    ..In our study, a disintegrin-like and metalloprotease with thrombospondin type 1 motif 9 (ADAMTS9), a gene mapping to 3p14.2, was identified to be critically associated with tumor suppression in NPC...
  52. Yao J, Zhou B, Zhang J, Geng P, Liu K, Zhu Y, et al. A new tumor suppressor LncRNA ADAMTS9-AS2 is regulated by DNMT1 and inhibits migration of glioma cells. Tumour Biol. 2014;35:7935-44 pubmed publisher
    ..A lncRNA, ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9) antisense RNA 2 (ADAMTS9-AS2), with unknown function, is the antisense transcript of tumor suppressor ADAMTS9...
  53. Barreto Luis A, Pino Yanes M, Corrales A, Campo P, Callero A, Acosta Herrera M, et al. Genome-wide association study in Spanish identifies ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9), as a novel asthma susceptibility gene. J Allergy Clin Immunol. 2016;137:964-6 pubmed publisher
  54. Du W, Wang S, Zhou Q, Li X, Chu J, Chang Z, et al. ADAMTS9 is a functional tumor suppressor through inhibiting AKT/mTOR pathway and associated with poor survival in gastric cancer. Oncogene. 2013;32:3319-28 pubmed publisher
    ..methylation analysis, we identified a disintegrin-like and metalloprotease with thrombospondin type 1 motif 9 (ADAMTS9) is methylated in cancer...
  55. Mychaleckyj J, Havt A, Nayak U, Pinkerton R, Farber E, Concannon P, et al. Genome-Wide Analysis in Brazilians Reveals Highly Differentiated Native American Genome Regions. Mol Biol Evol. 2017;34:559-574 pubmed publisher
    ..and KLHL29 (rs2288697) were most differentiated in the Amerindian-specific branch, while SNPs in the genes ADAMTS9 (rs7631391), DOCK2 (rs77594147), SLC28A1 (rs28649017), ARHGAP5 (rs7151991), and CIITA (rs45601437) were most ..
  56. Yaykasli K, Oohashi T, Hirohata S, Hatipoglu O, Inagawa K, Demircan K, et al. ADAMTS9 activation by interleukin 1 beta via NFATc1 in OUMS-27 chondrosarcoma cells and in human chondrocytes. Mol Cell Biochem. 2009;323:69-79 pubmed publisher
    b>ADAMTS9 is a member of the disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) genes, with aggrecan-degrading activity...
  57. Koo B, Coe D, Dixon L, Somerville R, Nelson C, Wang L, et al. ADAMTS9 is a cell-autonomously acting, anti-angiogenic metalloprotease expressed by microvascular endothelial cells. Am J Pathol. 2010;176:1494-504 pubmed publisher
    The metalloprotease ADAMTS9 participates in melanoblast development and is a tumor suppressor in esophageal and nasopharyngeal cancer. ADAMTS9 null mice die before gastrulation, but, ADAMTS9+/- mice were initially thought to be normal...
  58. Shao B, Feng Y, Zhang H, Yu F, Li Q, Tan C, et al. The 3p14.2 tumour suppressor ADAMTS9 is inactivated by promoter CpG methylation and inhibits tumour cell growth in breast cancer. J Cell Mol Med. 2017;: pubmed publisher
    Chromosome region 3p12-14 is an important tumour suppressor gene (TSG) locus for multiple cancers. ADAMTS9, a member of the metalloprotease large family, has been identified as a candidate 3p14...
  59. Randall J, Winkler T, Kutalik Z, Berndt S, Jackson A, Monda K, et al. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. PLoS Genet. 2013;9:e1003500 pubmed publisher (FDR<5%), including four previously established (near GRB14/COBLL1, LYPLAL1/SLC30A10, VEGFA, ADAMTS9) and three novel anthropometric trait loci (near MAP3K1, HSD17B4, PPARG), all of which were genome-wide ..
  60. Tang B. ADAMTS: a novel family of extracellular matrix proteases. Int J Biochem Cell Biol. 2001;33:33-44 pubmed
    ..Current and future studies on this emerging group of ECM proteases may provide important insights into developmental or pathological processes involving ECM remodeling. ..
  61. Simonis Bik A, Nijpels G, van Haeften T, Houwing Duistermaat J, Boomsma D, Reiling E, et al. Gene variants in the novel type 2 diabetes loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B affect different aspects of pancreatic beta-cell function. Diabetes. 2010;59:293-301 pubmed publisher
    ..All subjects were genotyped for gene variants in JAZF1, CDC123/CAMK1D, TSPAN8/LGR5, THADA, ADAMTS9, NOTCH2/ADAMS30, DCD, VEGFA, BCL11A, HNF1B, WFS1, and MTNR1B...
  62. Zeng W, Corcoran C, Collins Racie L, LaVallie E, Morris E, Flannery C. Glycosaminoglycan-binding properties and aggrecanase activities of truncated ADAMTSs: comparative analyses with ADAMTS-5, -9, -16 and -18. Biochim Biophys Acta. 2006;1760:517-24 pubmed
    ..Similarly, GAG-binding ability, irrespective of the presence of a TSR-1 domain, does not necessarily empower truncated ADAMTSs with proficient aggrecanase activity. ..
  63. Peng D, Wang J, Zhang R, Jiang F, Tam C, Jiang G, et al. CDKAL1 rs7756992 is associated with diabetic retinopathy in a Chinese population with type 2 diabetes. Sci Rep. 2017;7:8812 pubmed publisher
    ..In stage 1, 88 SNPs were genotyped in 1,251 patients with type 2 diabetes, and we found that ADAMTS9-AS2 rs4607103, WFS1 rs10010131, CDKAL1 rs7756992, VPS26A rs1802295 and IDE-KIF11-HHEX rs1111875 were ..
  64. Zhou D, Liu Y, Zhang D, Liu S, Yu L, Yang Y, et al. Variations in/nearby genes coding for JAZF1, TSPAN8/LGR5 and HHEX-IDE and risk of type 2 diabetes in Han Chinese. J Hum Genet. 2010;55:810-5 pubmed publisher
    Several genetic loci (JAZF1, CDC123/CAMK1D, TSPAN8/LGR5, ADAMTS9, VEGFA and HHEX-IDE) were identified to be significantly related to the risk of type 2 diabetes and quantitative metabolic traits in European populations...
  65. Boeuf S, Graf F, Fischer J, Moradi B, Little C, Richter W. Regulation of aggrecanases from the ADAMTS family and aggrecan neoepitope formation during in vitro chondrogenesis of human mesenchymal stem cells. Eur Cell Mater. 2012;23:320-32 pubmed
    ..Therapeutic aggrecanase inhibition for treatment of arthritic disease may thus not impede regenerative self-healing pathways based on chondrogenesis of local progenitor cells in the joint. ..
  66. Julià A, Pinto J, Gratacós J, Queiró R, Ferrándiz C, Fonseca E, et al. A deletion at ADAMTS9-MAGI1 locus is associated with psoriatic arthritis risk. Ann Rheum Dis. 2015;74:1875-81 pubmed publisher
    ..We found a highly significant association of an intergenic deletion between ADAMTS9 and MAGI1 genes on chromosome 3p14.1 (p=0.00014)...
  67. Chen L, Tang J, Feng Y, Li S, Xiang Q, He X, et al. ADAMTS9 is Silenced by Epigenetic Disruption in Colorectal Cancer and Inhibits Cell Growth and Metastasis by Regulating Akt/p53 Signaling. Cell Physiol Biochem. 2017;44:1370-1380 pubmed publisher
    ..Multiple studies suggest that ADAMTS proteins (e.g. ADAMTS9) can act as tumor suppressors...
  68. Uysal S, Ünal Z, Erdogan S, Akyol S, Ramazan Yiğitoğlu M, Hirohata S, et al. Augmentation of ADAMTS9 gene expression by IL-1? is reversed by NF?B and MAPK inhibitors, but not PI3 kinase inhibitors. Cell Biochem Funct. 2013;31:539-44 pubmed publisher
    The pathways involved in the regulation of a disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9) expression have not yet been elucidated...
  69. García Faroldi G, Rönnberg E, Orro A, Calounova G, Guss B, Lundequist A, et al. ADAMTS: novel proteases expressed by activated mast cells. Biol Chem. 2013;394:291-305 pubmed publisher
    ..Taken together, the present study reveals ADAMTS expression by MCs and that MC activation regulates the expression of these proteases, thus implicating the ADAMTS family of proteases in MC function. ..
  70. Wen J, Rönn T, Olsson A, Yang Z, Lu B, Du Y, et al. Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. PLoS ONE. 2010;5:e9153 pubmed publisher
  71. Lo P, Leung A, Kwok C, Cheung W, Ko J, Yang L, et al. Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9. Oncogene. 2007;26:148-57 pubmed
    ..2. This CR is bounded by D3S1600 and D3S1285 microsatellite markers. One candidate tumor suppressor gene, ADAMTS9, maps to this CR...
  72. Sprooten E, Fleming K, Thomson P, Bastin M, Whalley H, Hall J, et al. White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder. Psychiatry Res. 2013;206:223-31 pubmed publisher
  73. Wu Y, Lin J, Han B, Wang L, Chen Y, Liu M, et al. Proteomic profiling of follicle fluids after superstimulation in one-month-old lambs. Reprod Domest Anim. 2017;: pubmed publisher
    ..Many of the proteins known to affect follicle development were observed in lower abundance in FF of lamb (e.g. ADAMTS9, CD14, CTNNB1, FST, GCLC, HSPG2, IGFBP2, IGFBP6, INHBA, PRL, PAPPA, POSTN, PRDX1, SERPINA1, SOD3, STC1, VEGFC, ..
  74. Zhao J, Bradfield J, Zhang H, Annaiah K, Wang K, Kim C, et al. Examination of all type 2 diabetes GWAS loci reveals HHEX-IDE as a locus influencing pediatric BMI. Diabetes. 2010;59:751-5 pubmed publisher
    ..BMI with 20 single nucleotide polymorphisms at 18 type 2 diabetes loci uncovered through GWAS, consisting of ADAMTS9, CDC123-CAMK1D, CDKAL1, CDKN2A/B, EXT2, FTO, HHEX-IDE, IGF2BP2, the intragenic region on 11p12, JAZF1, KCNQ1, ..
  75. Koo B, Apte S. Cell-surface processing of the metalloprotease pro-ADAMTS9 is influenced by the chaperone GRP94/gp96. J Biol Chem. 2010;285:197-205 pubmed publisher
    A disintegrin-like and metalloprotease domain with thrombospondin type 1 motifs 9 (ADAMTS9) is a highly conserved metalloprotease that has been identified as a tumor suppressor gene and is required for normal mouse development...
  76. Lo P, Lung H, Cheung A, Apte S, Chan K, Kwong F, et al. Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis. Cancer Res. 2010;70:5567-76 pubmed publisher
    ADAMTS metalloprotease family member ADAMTS9 maps to 3p14.2 and shows significant associations with the aerodigestive tract cancers esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC)...
  77. Brito E, Lyssenko V, Renstrom F, Berglund G, Nilsson P, Groop L, et al. Previously associated type 2 diabetes variants may interact with physical activity to modify the risk of impaired glucose regulation and type 2 diabetes: a study of 16,003 Swedish adults. Diabetes. 2009;58:1411-8 pubmed publisher
    ..015 and 0.0068, respectively). Our observations suggest that the genetic predisposition to hyperglycemia is partially dependent on a person's lifestyle. ..
  78. Zhang C, Shao Y, Zhang W, Wu Q, Yang H, Zhong Q, et al. High-resolution melting analysis of ADAMTS9 methylation levels in gastric, colorectal, and pancreatic cancers. Cancer Genet Cytogenet. 2010;196:38-44 pubmed publisher
    ..The ADAMTS9 gene (ADAM metallopeptidase with thrombospondin type 1 motif, 9); has been characterized as a novel tumor ..
  79. Yoshina S, Sakaki K, Yonezumi Hayashi A, Gengyo Ando K, Inoue H, Iino Y, et al. Identification of a novel ADAMTS9/GON-1 function for protein transport from the ER to the Golgi. Mol Biol Cell. 2012;23:1728-41 pubmed publisher
    A disintegrin-like and metalloprotease with thrombospondin type I motif (ADAMTS9) is a member of the secreted metalloprotease family that is believed to digest extracellular matrix (ECM) proteins outside of cells...
  80. Coughlan T, Crawford A, Goldring M, Hatton P, Barker M. Lentiviral shRNA knock-down of ADAMTS-5 and -9 restores matrix deposition in 3D chondrocyte culture. J Tissue Eng Regen Med. 2010;4:611-8 pubmed publisher
    ..Moreover, this work also provides further evidence that ADAMTS-5 may be a therapeutic target in the treatment of arthritic disease. ..
  81. Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, et al. Underlying genetic models of inheritance in established type 2 diabetes associations. Am J Epidemiol. 2009;170:537-45 pubmed publisher
    ..Information on the genetic model of robustly replicated association signals derived from genome-wide association studies may be useful for predictive modeling and for designing biologic and functional experiments. ..
  82. Cross N, Chandrasekharan S, Jokonya N, Fowles A, Hamdy F, Buttle D, et al. The expression and regulation of ADAMTS-1, -4, -5, -9, and -15, and TIMP-3 by TGFbeta1 in prostate cells: relevance to the accumulation of versican. Prostate. 2005;63:269-75 pubmed
    ..The negative effect of TGFbeta1 on ADAMTS-1, -5, -9, and -15 coupled with increases in their inhibitor, TIMP-3 may aid the accumulation of versican in the stromal compartment of the prostate in BPH and prostate cancer. ..
  83. Kamboh M, Barmada M, Demirci F, Minster R, Carrasquillo M, Pankratz V, et al. Genome-wide association analysis of age-at-onset in Alzheimer's disease. Mol Psychiatry. 2012;17:1340-6 pubmed publisher
    ..These findings need to be confirmed in additional well-powered samples. ..
  84. Talmud P, Hingorani A, Cooper J, Marmot M, Brunner E, Kumari M, et al. Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. BMJ. 2010;340:b4838 pubmed publisher
  85. Hu C, Zhang R, Wang C, Wang J, Ma X, Lu J, et al. PPARG, KCNJ11, CDKAL1, CDKN2A-CDKN2B, IDE-KIF11-HHEX, IGF2BP2 and SLC30A8 are associated with type 2 diabetes in a Chinese population. PLoS ONE. 2009;4:e7643 pubmed publisher
    ..37E-12). But no significant association was detected between SNPs from WFS1, FTO, JAZF1, TSPAN8-LGR5, THADA, ADAMTS9, NOTCH2-ADAM30 and type 2 diabetes...
  86. Schulze M, Weikert C, Pischon T, Bergmann M, Al Hasani H, Schleicher E, et al. Use of multiple metabolic and genetic markers to improve the prediction of type 2 diabetes: the EPIC-Potsdam Study. Diabetes Care. 2009;32:2116-9 pubmed publisher
    ..002). Twenty SNPs did not improve discrimination beyond these characteristics (P = 0.69). Metabolic markers, but not genotyping for 20 diabetogenic SNPs, improve discrimination of incident type 2 diabetes beyond lifestyle risk factors. ..
  87. Park T, Hwang J, Go M, Lee H, Jang H, Choi Y, et al. Genome-wide association study of liver enzymes in korean children. Genomics Inform. 2013;11:149-54 pubmed publisher
    ..are some limitations, including genetic power, additional replication and functional characterization will support the clarity on the genetic contribution that the ST6GALNAC3, ADAMTS9, and CELF2 genes have in childhood liver function.
  88. Lin E, Tsai S, Kuo P, Liu Y, Yang A, Kao C, et al. The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population. PLoS ONE. 2017;12:e0172440 pubmed publisher
    ..within insulin resistance-associated genes, such as the ADAM metallopeptidase with thrombospondin type 1 motif 9 (ADAMTS9), glucokinase regulator (GCKR), and peroxisome proliferator activated receptor gamma (PPARG) genes, may be linked ..
  89. Lambert M, Portfors C. Adaptive sequence convergence of the tumor suppressor ADAMTS9 between small-bodied mammals displaying exceptional longevity. Aging (Albany NY). 2017;9:573-582 pubmed publisher
    ..sequence convergence in the gene A disintegrin-like and metalloprotease with thrombospondin type 1 motifs 9 (ADAMTS9). We also provide evidence that the shared substitutions were driven by selection...
  90. Lin C, Lin E, Lane H. Genetic Biomarkers on Age-Related Cognitive Decline. Front Psychiatry. 2017;8:247 pubmed publisher
    ..There is growing evidence that single-nucleotide polymorphisms (SNPs) within the ADAMTS9, BDNF, CASS4, COMT, CR1, DNMT3A, DTNBP1, REST, SRR, TOMM40, circadian clock, and Alzheimer's diseases-..
  91. Altuntas A, Halacli S, Cakmak O, Erden G, Akyol S, Ugurcu V, et al. Interleukin-1β induced nuclear factor-κB binds to a disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 promoter in human chondrosarcoma cells. Mol Med Rep. 2015;12:595-600 pubmed publisher
    ..A disintegrin-like and metalloproteinase with thrombospondin type 1 motif 9 (ADAMTS9) is a type of proteoglycanase, which proteolytically cleaves versican and aggrecan...