Gene Symbol: ADAM12
Description: ADAM metallopeptidase domain 12
Alias: ADAM12-OT1, CAR10, MCMP, MCMPMltna, MLTN, MLTNA, disintegrin and metalloproteinase domain-containing protein 12, meltrin-alpha, metalloprotease-disintegrin 12 transmembrane
Species: human
Products:     ADAM12

Top Publications

  1. Tanaka M, Nanba D, Mori S, Shiba F, Ishiguro H, Yoshino K, et al. ADAM binding protein Eve-1 is required for ectodomain shedding of epidermal growth factor receptor ligands. J Biol Chem. 2004;279:41950-9 pubmed
    ..regulatory mechanisms of ADAM activation, we performed yeast two-hybrid screening using the cytoplasmic domain of ADAM12 as bait, and identified a protein that we designated Eve-1. Two cDNAs were cloned and characterized...
  2. Le Pabic H, L Helgoualc h A, Coutant A, Wewer U, Baffet G, Clement B, et al. Involvement of the serine/threonine p70S6 kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells. J Hepatol. 2005;43:1038-44 pubmed
    ..We have recently reported that these cells synthesize ADAM12, a disintegrin and metalloprotease whose expression is up-regulated by TGF-beta1 in liver cancers...
  3. Stautz D, Leyme A, Grandal M, Albrechtsen R, van Deurs B, Wewer U, et al. Cell-surface metalloprotease ADAM12 is internalized by a clathrin- and Grb2-dependent mechanism. Traffic. 2012;13:1532-46 pubmed publisher
    b>ADAM12 (A Disintegrin And Metalloprotease 12), a member of the ADAMs family of transmembrane proteins, is involved in ectodomain shedding, cell-adhesion and signaling, with important implications in cancer...
  4. Estrella C, Rocks N, Paulissen G, Quesada Calvo F, Noel A, Vilain E, et al. Role of A disintegrin and metalloprotease-12 in neutrophil recruitment induced by airway epithelium. Am J Respir Cell Mol Biol. 2009;41:449-58 pubmed publisher
    ..These effects were mainly dependent on epidermal growth factor receptor activation. In summary, ADAM-12 is produced during allergic reaction by AEC and might increase neutrophil recruitment within airway mucosa. ..
  5. Harsha A, Stojadinovic O, Brem H, Sehara Fujisawa A, Wewer U, Loomis C, et al. ADAM12: a potential target for the treatment of chronic wounds. J Mol Med (Berl). 2008;86:961-9 pubmed publisher
    ..A disintegrin and metalloprotease 12 (ADAM12) is a membrane-anchored metalloprotease, which has been implicated in activation-inactivation of growth factors ..
  6. Fröhlich C, Albrechtsen R, Dyrskjøt L, Rudkjaer L, Ørntoft T, Wewer U. Molecular profiling of ADAM12 in human bladder cancer. Clin Cancer Res. 2006;12:7359-68 pubmed
    We have previously found ADAM12, a disintegrin and metalloprotease, to be an interesting biomarker for breast cancer...
  7. Laigaard J, Sørensen T, Fröhlich C, Pedersen B, Christiansen M, Schiøtt K, et al. ADAM12: a novel first-trimester maternal serum marker for Down syndrome. Prenat Diagn. 2003;23:1086-91 pubmed
    ..b>ADAM12 (A disintegrin and metalloprotease) is an IGFBP-3 and IGFBP-5 protease and is present in human pregnancy serum...
  8. Iba K, Albrechtsen R, Gilpin B, Frohlich C, Loechel F, Zolkiewska A, et al. The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading. J Cell Biol. 2000;149:1143-56 pubmed
  9. Uehara E, Shiiba M, Shinozuka K, Saito K, Kouzu Y, Koike H, et al. Upregulated expression of ADAM12 is associated with progression of oral squamous cell carcinoma. Int J Oncol. 2012;40:1414-22 pubmed publisher
    ..Real-time qRT-PCR analysis identified significantly upregulated expression of ADAM12 in OSCC-derived cell lines...

More Information


  1. Sundberg C, Thodeti C, Kveiborg M, Larsson C, Parker P, Albrechtsen R, et al. Regulation of ADAM12 cell-surface expression by protein kinase C epsilon. J Biol Chem. 2004;279:51601-11 pubmed
    ..The 90-kDa mature form of human ADAM12 is generated in the trans-Golgi through cleavage of the prodomain by a furin-peptidase and is stored ..
  2. Albrechtsen R, Stautz D, Sanjay A, Kveiborg M, Wewer U. Extracellular engagement of ADAM12 induces clusters of invadopodia with localized ectodomain shedding activity. Exp Cell Res. 2011;317:195-209 pubmed publisher
    ..Here, we demonstrate that antibody ligation of ADAM12, a transmembrane disintegrin and metalloprotease, resulted in the rapid accumulation of invadopodia with ..
  3. Atfi A, Dumont E, Colland F, Bonnier D, L Helgoualc h A, Prunier C, et al. The disintegrin and metalloproteinase ADAM12 contributes to TGF-beta signaling through interaction with the type II receptor. J Cell Biol. 2007;178:201-8 pubmed
    ..In this study, we identify ADAM12 (a disintegrin and metalloproteinase 12) as a component of the TGF-beta signaling pathway that acts through ..
  4. Thodeti C, Fröhlich C, Nielsen C, Takada Y, Fassler R, Albrechtsen R, et al. ADAM12-mediated focal adhesion formation is differently regulated by beta1 and beta3 integrins. FEBS Lett. 2005;579:5589-95 pubmed
    b>ADAM12, adisintegrin and metalloprotease, has been demonstrated to be upregulated in human malignant tumors and to accelerate the malignant phenotype in a mouse model for breast cancer...
  5. Lou S, Zhao Z, Qian J, Zhao K, Wang R. Association of single nucleotide polymorphisms in ADAM12 gene with susceptibility to knee osteoarthritis: a case-control study in a Chinese Han population. Int J Clin Exp Pathol. 2014;7:5154-9 pubmed
    Genetic factors play an important role in osteoarthritis (OA) etiology and ADAM12 gene polymorphisms may be involved...
  6. Spencer K, Cowans N, Uldbjerg N, Tørring N. First-trimester ADAM12s as early markers of trisomy 21: a promise still unfulfilled?. Prenat Diagn. 2008;28:338-42 pubmed publisher
    ..596 at a median gestation of 8.6 weeks. The data from this study does not support data from a previous study showing ultra-low levels of ADAM12s in pregnancies affected by trisomy 21 prior to 10 weeks of gestation. ..
  7. Kodama T, Ikeda E, Okada A, Ohtsuka T, Shimoda M, Shiomi T, et al. ADAM12 is selectively overexpressed in human glioblastomas and is associated with glioblastoma cell proliferation and shedding of heparin-binding epidermal growth factor. Am J Pathol. 2004;165:1743-53 pubmed
    ..intracranial tumors by reverse transcriptase-polymerase chain reaction, and found that prototype membrane-anchored ADAM12 (ADAM12m) is predominantly expressed in glioblastomas...
  8. Bourd Boittin K, Le Pabic H, Bonnier D, L Helgoualc h A, Theret N. RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis. J Biol Chem. 2008;283:26000-9 pubmed publisher
    b>ADAM12 belongs to a disintegrin-like and metalloproteinase-containing protein family that possesses multidomain structures composed of a pro-domain, a metalloprotease, disintegrin-like, cysteine-rich, epidermal growth factor-like, and ..
  9. Laigaard J, Sørensen T, Placing S, Holck P, Fröhlich C, Wøjdemann K, et al. Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia. Obstet Gynecol. 2005;106:144-9 pubmed
    The secreted form of ADAM12 is a metalloprotease that may be involved in placental and fetal growth. We examined whether the concentration of ADAM12 in first-trimester maternal serum could be used as a marker for preeclampsia...
  10. Li H, Solomon E, Duhachek Muggy S, Sun D, Zolkiewska A. Metalloprotease-disintegrin ADAM12 expression is regulated by Notch signaling via microRNA-29. J Biol Chem. 2011;286:21500-10 pubmed publisher
    Metalloprotease-disintegrin ADAM12 is overexpressed and frequently mutated in breast cancer. We report here that ADAM12 expression in cultured mammalian cells is up-regulated by Notch signals...
  11. Valinen Y, Peuhkurinen S, Järvelä I, Laitinen P, Ryynanen M. Maternal serum ADAM12 levels correlate with PAPP-A levels during the first trimester. Gynecol Obstet Invest. 2010;70:60-3 pubmed publisher
    We wished to investigate the correlation between a new Down screening marker ADAM12 (a disintegrin and metalloproteinase-12) and pregnancy-associated plasma protein-A (PAPP-A) and free beta-human chorionic gonadotropin (fbeta-hCG) during ..
  12. Christiansen M, Pihl K, Hedley P, Gjerris A, Lind P, Larsen S, et al. ADAM 12 may be used to reduce the false positive rate of first trimester combined screening for Down syndrome. Prenat Diagn. 2010;30:110-4 pubmed publisher
    b>ADAM12 has been shown to be an efficient maternal serum marker for Down syndrome (DS) in the first trimester; but recent studies, using a second generation assay, have not confirmed these findings...
  13. Narita D, Anghel A, Seclaman E, Ilina R, Cireap N, Ursoniu S. Molecular profiling of ADAM12 gene in breast cancers. Rom J Morphol Embryol. 2010;51:669-76 pubmed
    ..b>ADAM12 is highly expressed in rapidly growing tissues such as placenta and malignant tumors and it was found as one of ..
  14. Poon L, Chelemen T, Granvillano O, Pandeva I, Nicolaides K. First-trimester maternal serum a disintegrin and metalloprotease 12 (ADAM12) and adverse pregnancy outcome. Obstet Gynecol. 2008;112:1082-90 pubmed publisher
    To examine the possible association of maternal serum a disintegrin and metalloprotease (ADAM12) in the first trimester of pregnancy and subsequent development of preeclampsia, delivery of small for gestational age (SGA) neonates, and ..
  15. Laigaard J, Cuckle H, Wewer U, Christiansen M. Maternal serum ADAM12 levels in Down and Edwards' syndrome pregnancies at 9-12 weeks' gestation. Prenat Diagn. 2006;26:689-91 pubmed
    Maternal serum ADAM12 is reduced, on average, in early first-trimester Down and Edwards' syndrome pregnancies but the extent of reduction declines with gestation...
  16. Carl McGrath S, Lendeckel U, Ebert M, Roessner A, Rocken C. The disintegrin-metalloproteinases ADAM9, ADAM12, and ADAM15 are upregulated in gastric cancer. Int J Oncol. 2005;26:17-24 pubmed
    ..three ADAMs were found to be significantly upregulated in GC compared to non-neoplastic foveolar epithelium, with ADAM12 expression being higher in intestinal- than in diffuse-type tumors...
  17. Stautz D, Sanjay A, Hansen M, Albrechtsen R, Wewer U, Kveiborg M. ADAM12 localizes with c-Src to actin-rich structures at the cell periphery and regulates Src kinase activity. Exp Cell Res. 2010;316:55-67 pubmed publisher
    b>ADAM12 is an active metalloprotease playing an important role in tumour progression. Human ADAM12 exists in two splice variants: a long transmembrane form, ADAM12-L, and a secreted form, ADAM12-S...
  18. Rao V, Kandel A, Lynch D, Pena Z, Marwaha N, Deng C, et al. A positive feedback loop between HER2 and ADAM12 in human head and neck cancer cells increases migration and invasion. Oncogene. 2012;31:2888-98 pubmed publisher
    ..HER2 expression was significantly correlated with ADAM12 (A Disintegrin And Metalloprotease 12) expression in these cell lines and was co-expressed in human head and neck ..
  19. Rocks N, Paulissen G, Quesada Calvo F, Polette M, Gueders M, Munaut C, et al. Expression of a disintegrin and metalloprotease (ADAM and ADAMTS) enzymes in human non-small-cell lung carcinomas (NSCLC). Br J Cancer. 2006;94:724-30 pubmed
    ..Taken together, these results providing evidence for an overexpression of ADAM-12 and a lower expression of ADAMTS-1 in non-small-cell lung cancer suggest that these proteases play different functions in cancer progression. ..
  20. Rocks N, Estrella C, Paulissen G, Quesada Calvo F, Gilles C, Gueders M, et al. The metalloproteinase ADAM-12 regulates bronchial epithelial cell proliferation and apoptosis. Cell Prolif. 2008;41:988-1001 pubmed publisher
    ..ADAM-12 contributes to enhancing HB-EGF shedding from plasma membranes leading to increased cell proliferation and reduced apoptosis in this bronchial epithelial cell line. ..
  21. Fröhlich C, Nehammer C, Albrechtsen R, Kronqvist P, Kveiborg M, Sehara Fujisawa A, et al. ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression. Mol Cancer Res. 2011;9:1449-61 pubmed publisher
    Expression of ADAM12 is low in most normal tissues but is markedly increased in numerous human cancers, including breast carcinomas...
  22. Okada A, Mochizuki S, Yatabe T, Kimura T, Shiomi T, Fujita Y, et al. ADAM-12 (meltrin alpha) is involved in chondrocyte proliferation via cleavage of insulin-like growth factor binding protein 5 in osteoarthritic cartilage. Arthritis Rheum. 2008;58:778-89 pubmed publisher
    ..These data suggest a novel function of ADAM-12m in chondrocyte proliferation and cloning in OA cartilage through enhanced bioavailability of IGF-1 from the IGF-1-IGFBP-5 complex by selective IGFBP-5 digestion. ..
  23. Roy R, Rodig S, Bielenberg D, Zurakowski D, Moses M. ADAM12 transmembrane and secreted isoforms promote breast tumor growth: a distinct role for ADAM12-S protein in tumor metastasis. J Biol Chem. 2011;286:20758-68 pubmed publisher
    Increased levels of ADAM12 have been reported in a variety of human cancers...
  24. Diaz B, Yuen A, Iizuka S, Higashiyama S, Courtneidge S. Notch increases the shedding of HB-EGF by ADAM12 to potentiate invadopodia formation in hypoxia. J Cell Biol. 2013;201:279-92 pubmed publisher
    ..In this paper, we show that, in cancer cells, hypoxia increased the levels and activity of the ADAM12 metalloprotease in a Notch signaling-dependent manner, leading to increased ectodomain shedding of the epidermal ..
  25. Narita D, Seclaman E, Ursoniu S, Anghel A. Increased expression of ADAM12 and ADAM17 genes in laser-capture microdissected breast cancers and correlations with clinical and pathological characteristics. Acta Histochem. 2012;114:131-9 pubmed publisher
    ..Our aim was to evaluate ADAM12 spliced variants (ADAM12L - long membrane-bound and ADAM12S - secreted-short variant) and ADAM17 genes expression ..
  26. Li H, Duhachek Muggy S, Qi Y, Hong Y, Behbod F, Zolkiewska A. An essential role of metalloprotease-disintegrin ADAM12 in triple-negative breast cancer. Breast Cancer Res Treat. 2012;135:759-69 pubmed publisher
    ..These studies suggest that ADAM12L is the primary protease responsible for the activation of EGFR in early stage, lymph node-negative TNBCs. Thus, our results may provide novel insight into the biology of TNBC. ..
  27. Iba K, Albrechtsen R, Gilpin B, Loechel F, Wewer U. Cysteine-rich domain of human ADAM 12 (meltrin alpha) supports tumor cell adhesion. Am J Pathol. 1999;154:1489-501 pubmed
    ..By immunostaining, ADAM 12 (meltrin alpha) was up-regulated in several human carcinomas and could be detected along the tumor cell membranes...
  28. Kawaguchi N, Sundberg C, Kveiborg M, Moghadaszadeh B, Asmar M, Dietrich N, et al. ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function. J Cell Sci. 2003;116:3893-904 pubmed
    ..In this study we report that the expression of ADAM12, a disintegrin and metalloprotease, dramatically affects cell morphology in preadipocytes, changing them from a ..
  29. Spencer K, Cowans N, Stamatopoulou A. Maternal serum ADAM12s in the late first trimester of pregnancies with Trisomy 21. Prenat Diagn. 2008;28:422-4 pubmed publisher
    ..More studies are required looking at the potential of ADAM12s prior to 10 weeks. ..
  30. Suzuki A, Kadota N, Hara T, Nakagami Y, Izumi T, Takenawa T, et al. Meltrin alpha cytoplasmic domain interacts with SH3 domains of Src and Grb2 and is phosphorylated by v-Src. Oncogene. 2000;19:5842-50 pubmed
    b>Meltrin alpha/ADAM12 is a member of the ADAM/MDC family proteins characterized by the presence of metalloprotease and disintegrin domains...
  31. Poon L, Chelemen T, Minekawa R, Frisova V, Nicolaides K. Maternal serum ADAM12 (A disintegrin and metalloprotease) in chromosomally abnormal pregnancy at 11-13 weeks. Am J Obstet Gynecol. 2009;200:508.e1-6 pubmed publisher
    The objective of this study was to investigate the potential value of ADAM12 (A disintegrin and metalloprotease) in first-trimester screening for trisomy 21 and other major chromosomal abnormalities...
  32. Sørensen H, Vivès R, Manetopoulos C, Albrechtsen R, Lydolph M, Jacobsen J, et al. Heparan sulfate regulates ADAM12 through a molecular switch mechanism. J Biol Chem. 2008;283:31920-32 pubmed publisher
    ..Unlike other metzincins, ADAM prodomains remain bound to the mature enzyme to regulate activity. Here ADAM12, a protease that promotes tumor progression and chondrocyte proliferation in osteoarthritic cartilage, is shown to ..
  33. Thodeti C, Albrechtsen R, Grauslund M, Asmar M, Larsson C, Takada Y, et al. ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA. J Biol Chem. 2003;278:9576-84 pubmed
    ..The ADAM12 cysteine-rich domain (rADAM12-cys) supports cell attachment using syndecan-4 as a primary cell surface receptor ..
  34. Lafuste P, Sonnet C, Chazaud B, Dreyfus P, Gherardi R, Wewer U, et al. ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation. Mol Biol Cell. 2005;16:861-70 pubmed
    ..b>ADAM12 is likely involved in fusion of murine mpc and human rhabdomyosarcoma cells, but it requires yet unknown molecular ..
  35. Valinen Y, Laitinen P, Ranta J, Ignatius J, Jarvela I, Ryynanen M. Effect of a new marker, ADAM12, on Down risk figures in first trimester screening. J Matern Fetal Neonatal Med. 2009;22:602-7 pubmed publisher
    To investigate whether incorporating the measurement of ADAM12 in the risk calculation program LifeCycle, can improve Down screening in the first trimester...
  36. Li H, Duhachek Muggy S, Dubnicka S, Zolkiewska A. Metalloproteinase-disintegrin ADAM12 is associated with a breast tumor-initiating cell phenotype. Breast Cancer Res Treat. 2013;139:691-703 pubmed publisher
    ..We postulate that ADAM12L may serve as a novel marker and/or a novel therapeutic target in BTICs. ..
  37. Gilpin B, Loechel F, Mattei M, Engvall E, Albrechtsen R, Wewer U. A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo. J Biol Chem. 1998;273:157-66 pubmed
    ..In this report we describe a novel, secreted form of human ADAM 12 (meltrin alpha), designated ADAM 12-S (S for short), and a larger, membrane-bound form designated ADAM 12-L (L for long form)...
  38. Loechel F, Gilpin B, Engvall E, Albrechtsen R, Wewer U. Human ADAM 12 (meltrin alpha) is an active metalloprotease. J Biol Chem. 1998;273:16993-7 pubmed
    ..We recently described the cloning and sequencing of human ADAM 12 (meltrin alpha). In this report we provide evidence that the metalloprotease domain of ADAM 12 is catalytically active...
  39. Tian B, Wen J, Zhang M, Xie D, Xu R, Luo C. The expression of ADAM12 (meltrin alpha) in human giant cell tumours of bone. Mol Pathol. 2002;55:394-7 pubmed
    To examine the expression of ADAM12 (meltrin alpha), a member of the disintegrin and metalloprotease (ADAM) family, in human giant cell tumours of the bone, skeletal muscle tissue from human embryos, and human adult skeletal muscle ..
  40. Valdes A, Van Oene M, Hart D, Surdulescu G, Loughlin J, Doherty M, et al. Reproducible genetic associations between candidate genes and clinical knee osteoarthritis in men and women. Arthritis Rheum. 2006;54:533-9 pubmed
    ..The 12 genes tested were AACT, ADAM12, BMP2, CD36, CILP, COX2, ESR1, NCOR2, OPG, TNA, TNFAIP6, and VDR...
  41. Spencer K, Cowans N. ADAM12 as a marker of trisomy 18 in the first and second trimester of pregnancy. J Matern Fetal Neonatal Med. 2007;20:645-50 pubmed
    b>ADAM12 (a disintegrin and metalloprotease 12) is a placentally derived glycoprotein that appears to be involved in growth and differentiation...
  42. Duhachek Muggy S, Li H, Qi Y, Zolkiewska A. Alternative mRNA splicing generates two distinct ADAM12 prodomain variants. PLoS ONE. 2013;8:e75730 pubmed publisher
    Human ADAM12, transcript variant 1 (later on referred to as Var-1b), present in publicly available databases contains the sequence 5'-GTAATTCTG-3' at the nucleotide positions 340-348 of the coding region, at the 3' end of exon 4...
  43. Loechel F, Fox J, Murphy G, Albrechtsen R, Wewer U. ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3. Biochem Biophys Res Commun. 2000;278:511-5 pubmed
    ..Cleavage of both IGFBP-3 and -5 by ADAM 12-S was inhibited by TIMP-3, raising the possibility that TIMP-3 is a physiological inhibitor of ADAM 12-S. ..
  44. Zhao Z, Gruszczynska Biegala J, Cheuvront T, Yi H, von der Mark H, von der Mark K, et al. Interaction of the disintegrin and cysteine-rich domains of ADAM12 with integrin alpha7beta1. Exp Cell Res. 2004;298:28-37 pubmed
    We describe a novel interaction between the disintegrin and cysteine-rich (DC) domains of ADAM12 and the integrin alpha7beta1...
  45. Solomon E, Li H, Duhachek Muggy S, Syta E, Zolkiewska A. The role of SnoN in transforming growth factor beta1-induced expression of metalloprotease-disintegrin ADAM12. J Biol Chem. 2010;285:21969-77 pubmed publisher
    Increased expression of metalloprotease-disintegrin ADAM12 is a hallmark of several pathological conditions, including cancer, cardiovascular disease, and certain inflammatory diseases of the central nervous system or the muscoskeletal ..
  46. Cowans N, Spencer K. First-trimester ADAM12 and PAPP-A as markers for intrauterine fetal growth restriction through their roles in the insulin-like growth factor system. Prenat Diagn. 2007;27:264-71 pubmed
    ..b>ADAM12 is a recently discovered pregnancy associated member of the ADAM (a multidomain glycoprotein metalloprotease) ..
  47. Wortelboer E, Linskens I, Koster M, Stoutenbeek P, Cuckle H, Blankenstein M, et al. ADAM12s as a first-trimester screening marker of trisomy. Prenat Diagn. 2009;29:866-9 pubmed publisher
    ..However, the screening performance for DS did not greatly improve adding ADAM12s. ADAM12s could be an additional biochemical marker for first-trimester screening for trisomies other than DS. ..
  48. Pihl K, Larsen T, Krebs L, Christiansen M. First trimester maternal serum PAPP-A, beta-hCG and ADAM12 in prediction of small-for-gestational-age fetuses. Prenat Diagn. 2008;28:1131-5 pubmed publisher
    ..plasma protein A (PAPP-A), beta-human chorionic gonadotrophin (beta-hCG) and A disintegrin and metalloprotease 12 (ADAM12) in first trimester...
  49. Rausch M, Beer L, Sammel M, Takacs P, Chung K, Shaunik A, et al. A disintegrin and metalloprotease protein-12 as a novel marker for the diagnosis of ectopic pregnancy. Fertil Steril. 2011;95:1373-8 pubmed publisher
    ..Further studies in additional patient populations and in combination with other biomarkers are needed. ..
  50. Yagami Hiromasa T, Sato T, Kurisaki T, Kamijo K, Nabeshima Y, Fujisawa Sehara A. A metalloprotease-disintegrin participating in myoblast fusion. Nature. 1995;377:652-6 pubmed
    ..Involvement of a fertilin-related protein in myogenesis suggests that there are common mechanisms in gamete and myoblast fusion. ..
  51. Dyczynska E, Syta E, Sun D, Zolkiewska A. Breast cancer-associated mutations in metalloprotease disintegrin ADAM12 interfere with the intracellular trafficking and processing of the protein. Int J Cancer. 2008;122:2634-40 pubmed publisher
    b>ADAM12 has recently emerged as a Candidate Cancer Gene in a comprehensive genetic analysis of human breast cancers. Three somatic mutations in ADAM12 were observed at significant frequencies in breast cancers: D301H, G479E and L792F...
  52. Eto K, Puzon McLaughlin W, Sheppard D, Sehara Fujisawa A, Zhang X, Takada Y. RGD-independent binding of integrin alpha9beta1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction. J Biol Chem. 2000;275:34922-30 pubmed
  53. Kanakis D, Lendeckel U, Theodosiou P, Dobrowolny H, Mawrin C, Keilhoff G, et al. ADAM 12: a putative marker of oligodendrogliomas?. Dis Markers. 2013;34:81-91 pubmed publisher
    ADAM 12 (meltrin alpha) belongs to a large family of molecules, consisting of members with both disintegrin and metalloproteinase properties...
  54. Mino N, Miyahara R, Nakayama E, Takahashi T, Takahashi A, Iwakiri S, et al. A disintegrin and metalloprotease 12 (ADAM12) is a prognostic factor in resected pathological stage I lung adenocarcinoma. J Surg Oncol. 2009;100:267-72 pubmed publisher
    A disintegrin and metalloprotease 12 (ADAM12) has multiple domains and functions, and it plays important roles in the development of cancer...
  55. Stautz D, Wewer U, Kveiborg M. Functional analysis of a breast cancer-associated mutation in the intracellular domain of the metalloprotease ADAM12. PLoS ONE. 2012;7:e37628 pubmed publisher
    A recently identified breast cancer-associated mutation in the metalloprotease ADAM12 alters a potential dileucine trafficking signal, which could affect protein processing and cellular localization...
  56. Spencer K, Vereecken A, Cowans N. Maternal serum ADAM12s as a potential marker of trisomy 21 prior to 10 weeks of gestation. Prenat Diagn. 2008;28:209-11 pubmed publisher
    ..Combining the data from this study and from the only other published study with data prior to 10 weeks suggests that ADAM12s may have the potential as an early screening marker for trisomy 21, but may not be as reduced as first thought. ..
  57. Cao Y, Kang Q, Zhao Z, Zolkiewska A. Intracellular processing of metalloprotease disintegrin ADAM12. J Biol Chem. 2002;277:26403-11 pubmed
    b>ADAM12 has been implicated in cell-cell interactions in myogenesis and cancer, but the structure of the mature form of ADAM12 is not known, and its localization on the cell surface has been questioned...
  58. Kveiborg M, Fröhlich C, Albrechtsen R, Tischler V, Dietrich N, Holck P, et al. A role for ADAM12 in breast tumor progression and stromal cell apoptosis. Cancer Res. 2005;65:4754-61 pubmed
    ..Furthermore, we show that ADAM12, a disintegrin and metalloprotease up-regulated in human breast cancer, accelerates tumor progression in a mouse ..
  59. Qi Y, Duhachek Muggy S, Li H, Zolkiewska A. Phenotypic diversity of breast cancer-related mutations in metalloproteinase-disintegrin ADAM12. PLoS ONE. 2014;9:e92536 pubmed publisher
    Six different somatic missense mutations in the human ADAM12 gene have been identified so far in breast cancer. Five of these mutations involve highly conserved residues in the extracellular domain of the transmembrane ADAM12-L protein...
  60. Sahraravand M, Järvelä I, Laitinen P, Tekay A, Ryynanen M. The secretion of PAPP-A, ADAM12, and PP13 correlates with the size of the placenta for the first month of pregnancy. Placenta. 2011;32:999-1003 pubmed publisher
    Pregnancy Associated Protein A (PAPP-A), A Disintegrin and Metalloproteinase 12 (ADAM12) and Placental Protein 13 (PP13) are secreted from the placental trophoblastic tissue and are involved in normal implantation and placental ..
  61. Kerna I, Kisand K, Tamm A, Lintrop M, Veske K, Tamm A. Missense single nucleotide polymorphism of the ADAM12 gene is associated with radiographic knee osteoarthritis in middle-aged Estonian cohort. Osteoarthritis Cartilage. 2009;17:1093-8 pubmed publisher
    One of the recognized candidate genes of osteoarthritis (OA) is the ADAM metallopeptidase domain 12 (meltrin alpha) gene...
  62. Thodeti C, Fröhlich C, Nielsen C, Holck P, Sundberg C, Kveiborg M, et al. Hierarchy of ADAM12 binding to integrins in tumor cells. Exp Cell Res. 2005;309:438-50 pubmed
    ..Using different forms and fragments of ADAM12 as substrates in cell adhesion and spreading assays, we demonstrated that alpha9beta1 integrin is the main ..
  63. Mori S, Tanaka M, Nanba D, Nishiwaki E, Ishiguro H, Higashiyama S, et al. PACSIN3 binds ADAM12/meltrin alpha and up-regulates ectodomain shedding of heparin-binding epidermal growth factor-like growth factor. J Biol Chem. 2003;278:46029-34 pubmed
    A disintegrin and metalloprotease 12 (ADAM12/meltrin alpha) is a key enzyme implicated in the ectodomain shedding of membrane-anchored heparin-binding epidermal growth factor (EGF)-like growth factor (proHB-EGF)-dependent epidermal ..
  64. Shi Z, Xu W, Loechel F, Wewer U, Murphy L. ADAM 12, a disintegrin metalloprotease, interacts with insulin-like growth factor-binding protein-3. J Biol Chem. 2000;275:18574-80 pubmed
    ..The data suggest that ADAM 12-S has IGFBP-3 protease activity, and it may contribute to the IGFBP-3 protease activity present in pregnancy serum. ..
  65. Horne A, Brown J, Tong S, Kaitu u Lino T. Evaluation of ADAM-12 as a diagnostic biomarker of ectopic pregnancy in women with a pregnancy of unknown location. PLoS ONE. 2012;7:e41442 pubmed publisher
    ..6633; P?=?0.03901). When measured in isolation, ADAM-12 levels had limited value as a diagnostic biomarker for EP in our patient cohort. The development of a reliable serum biomarker-based test for EP remains an ongoing challenge. ..
  66. Kveiborg M, Albrechtsen R, Couchman J, Wewer U. Cellular roles of ADAM12 in health and disease. Int J Biochem Cell Biol. 2008;40:1685-702 pubmed publisher
    b>ADAM12 belongs to the large family of ADAMs (a disintegrin and metalloproteases) and possesses extracellular metalloprotease and cell-binding functions, as well as intracellular signaling capacities...
  67. Abram C, Seals D, Pass I, Salinsky D, Maurer L, Roth T, et al. The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells. J Biol Chem. 2003;278:16844-51 pubmed
    ..In Src-transformed cells, ADAM12 co-localized with Fish in podosomes...
  68. Galliano M, Huet C, Frygelius J, Polgren A, Wewer U, Engvall E. Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha -actinin-2, is required for myoblast fusion. J Biol Chem. 2000;275:13933-9 pubmed
    b>ADAM12 belongs to the transmembrane metalloprotease ADAM ("a disintegrin and metalloprotease") family. ADAM12 has been implicated in muscle cell differentiation and fusion, but its precise function remains unknown...
  69. Kerna I, Kisand K, Laitinen P, Tamm A, Kumm J, Lintrop M, et al. Association of ADAM12-S protein with radiographic features of knee osteoarthritis and bone and cartilage markers. Rheumatol Int. 2012;32:519-23 pubmed publisher
    b>ADAM12 (A disintegrin and metalloprotease) is one of the candidate genes demonstrating susceptibility to osteoarthritis...
  70. Fröhlich C, Klitgaard M, Noer J, Kotzsch A, Nehammer C, Kronqvist P, et al. ADAM12 is expressed in the tumour vasculature and mediates ectodomain shedding of several membrane-anchored endothelial proteins. Biochem J. 2013;452:97-109 pubmed publisher
    ADAM (a disintegrin and metalloproteinase) 12 is a metalloprotease implicated in cancer progression. ADAM12 can activate membrane-anchored proteins, such as sonic hedgehog, Delta-like 1 and certain epidermal growth factor receptor ligands,..
  71. Roy R, Wewer U, Zurakowski D, Pories S, Moses M. ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage. J Biol Chem. 2004;279:51323-30 pubmed
    ..They further support the possibility that detection of urinary ADAM 12 may prove useful in the development of noninvasive diagnostic and prognostic tests for breast and perhaps other cancers. ..
  72. Shin M, Lee S, Kee S, Song S, Kweon S, Park D, et al. Genetic association analysis of GDF5 and ADAM12 for knee osteoarthritis. Joint Bone Spine. 2012;79:488-91 pubmed publisher
    ..aged 50 years and older were assessed for OA at the knee, were genotyped with two SNPs (GDF5; rs143383 and ADAM12; rs3740199)...
  73. Asakura M, Kitakaze M, Takashima S, Liao Y, Ishikura F, Yoshinaka T, et al. Cardiac hypertrophy is inhibited by antagonism of ADAM12 processing of HB-EGF: metalloproteinase inhibitors as a new therapy. Nat Med. 2002;8:35-40 pubmed
    ..We cloned a disintegrin and metalloprotease 12 (ADAM12) as a specific enzyme to shed HB-EGF in the heart and found that dominant-negative expression of ADAM12 abrogated ..
  74. Le Pabic H, Bonnier D, Wewer U, Coutand A, Musso O, Baffet G, et al. ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling. Hepatology. 2003;37:1056-66 pubmed
    ..Using degenerative RT-PCR, cDNA encoding sequences for ADAM9 and ADAM12 were identified in human activated hepatic stellate cells (HSCs)...