ACVR2B

Summary

Gene Symbol: ACVR2B
Description: activin A receptor type 2B
Alias: ACTRIIB, ActR-IIB, HTX4, activin receptor type-2B, activin A receptor, type IIB
Species: human
Products:     ACVR2B

Top Publications

  1. Lee S, McPherron A. Regulation of myostatin activity and muscle growth. Proc Natl Acad Sci U S A. 2001;98:9306-11 pubmed
    ..Our findings suggest that the propeptide, follistatin, or other molecules that block signaling through this pathway may be useful agents for enhancing muscle growth for both human therapeutic and agricultural applications. ..
  2. Nomura M, Morinaga H, Zhu H, Wang L, Hasuzawa N, Takayanagi R, et al. Activation of activin type IB receptor signals in pancreatic β cells leads to defective insulin secretion through the attenuation of ATP-sensitive K+ channel activity. Biochem Biophys Res Commun. 2014;450:440-6 pubmed publisher
    In studies of gene-ablated mice, activin signaling through activin type IIB receptors (ActRIIB) and Smad2 has been shown to regulate not only pancreatic β cell mass but also insulin secretion...
  3. McCoy J, Walker R, Murray N, Thompson T. Crystal structure of the WFIKKN2 follistatin domain reveals insight into how it inhibits growth differentiation factor 8 (GDF8) and GDF11. J Biol Chem. 2019;294:6333-6343 pubmed publisher
    ..with both GDF8 and GDF11 and block their interactions with the type II receptor activin A receptor type 2B (ActRIIB). Further, we solved the crystal structure of the WFIKKN2 FSD to 1...
  4. Miura S, Takeshita T, Asao H, Kimura Y, Murata K, Sasaki Y, et al. Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. Mol Cell Biol. 2000;20:9346-55 pubmed
    ..5. Mutant cells showed significantly decreased responses to stimulation with activin and TGF-beta. These findings suggest that the two FYVE domain proteins, Hgs and SARA, are prerequisites for receptor-mediated activation of Smad2. ..
  5. Tang L, Li N, Jian W, Kang Y, Yin B, Sun S, et al. Low-intensity pulsed ultrasound prevents muscle atrophy induced by type 1 diabetes in rats. Skelet Muscle. 2017;7:29 pubmed publisher
    ..Akt and upregulated the expression of mTOR, and LIPUS downregulated the expression of MSTN, its receptor ActRIIB, and FoxO1...
  6. O Connell K, Guo W, Serra C, Beck M, Wachtman L, Hoggatt A, et al. The effects of an ActRIIb receptor Fc fusion protein ligand trap in juvenile simian immunodeficiency virus-infected rhesus macaques. FASEB J. 2015;29:1165-75 pubmed publisher
    ..To determine whether a soluble ActRIIb receptor Fc fusion protein (ActRIIB...
  7. Rochette L, Zeller M, Cottin Y, Vergely C. Growth and differentiation factor 11 (GDF11): Functions in the regulation of erythropoiesis and cardiac regeneration. Pharmacol Ther. 2015;156:26-33 pubmed publisher
    ..The binding of activins to activin type IIA (ActRIIA) or type IIB (ActRIIB) receptors induces the recruitment and phosphorylation of an activin type I receptor which then phosphorylates ..
  8. Cui W, Bennett A, Zhang P, Barrow K, Kearney S, Hankey K, et al. A non-human primate model of radiation-induced cachexia. Sci Rep. 2016;6:23612 pubmed publisher
    ..Levels of FBXO32 (Atrogin-1), ActRIIB and myostatin were significantly changed in the irradiated cachectic NHP compared to the non-irradiated NHP...
  9. Yang J, Sun L, Fan X, Yin B, Kang Y, An S, et al. Pulsed electromagnetic fields alleviate streptozotocin‑induced diabetic muscle atrophy. Mol Med Rep. 2018;18:1127-1133 pubmed publisher
    ..However, pulsed electromagnetic fields (PEMFs) can retard the atrophy of type II fibers (ActRIIB) in denervated muscles...

More Information

Publications142 found, 100 shown here

  1. Magga J, Vainio L, Kilpiö T, Hulmi J, Taponen S, Lin R, et al. Systemic Blockade of ACVR2B Ligands Protects Myocardium from Acute Ischemia-Reperfusion Injury. Mol Ther. 2019;27:600-610 pubmed publisher
    ..The aim of this study was to investigate if activin 2B (ACVR2B) receptor ligands contribute to myocardial IR injury...
  2. Castonguay R, Lachey J, Wallner S, Strand J, Liharska K, Watanabe A, et al. Follistatin-288-Fc Fusion Protein Promotes Localized Growth of Skeletal Muscle. J Pharmacol Exp Ther. 2019;368:435-445 pubmed publisher
    ..to the systemic effects of a locally administered fusion protein incorporating activin receptor type IIB (ActRIIB-Fc)...
  3. Wang Q, Guo T, Portas J, McPherron A. A soluble activin receptor type IIB does not improve blood glucose in streptozotocin-treated mice. Int J Biol Sci. 2015;11:199-208 pubmed publisher
    ..After diabetes developed, mice were treated with a soluble MSTN/activin receptor fused to Fc (ACVR2B:Fc). ACVR2B:Fc increased body weight and muscle mass compared to vehicle treated mice...
  4. Li R, Ferreira M, Cooke M, La Bounty P, Campbell B, Greenwood M, et al. Co-ingestion of carbohydrate with branched-chain amino acids or L-leucine does not preferentially increase serum IGF-1 and expression of myogenic-related genes in response to a single bout of resistance exercise. Amino Acids. 2015;47:1203-13 pubmed publisher
    ..Serum IGF-1 was determined with ELISA, and skeletal muscle mRNA expression of myostatin, ACTRIIB, p21kip, p27kip, CDK2, cyclin B1, cyclin D1, Myo-D, myogenin, MRF-4, and myf5 was determined using real-time PCR...
  5. Béchir N, Pecchi Ã, Relizani K, Vilmen C, Le Fur Y, Bernard M, et al. Mitochondrial impairment induced by postnatal ActRIIB blockade does not alter function and energy status in exercising mouse glycolytic muscle in vivo. Am J Physiol Endocrinol Metab. 2016;310:E539-49 pubmed publisher
    Because it leads to a rapid and massive muscle hypertrophy, postnatal blockade of the activin type IIB receptor (ActRIIB) is a promising therapeutic strategy for counteracting muscle wasting...
  6. Carrarelli P, Funghi L, Ciarmela P, Centini G, Reis F, Dela Cruz C, et al. Deep Infiltrating Endometriosis and Endometrial Adenocarcinoma Express High Levels of Myostatin and Its Receptors Messenger RNAs. Reprod Sci. 2017;24:1577-1582 pubmed publisher
    ..kinase 4 [ALK4], transforming growth factor (TGF)-? type I receptor kinase [ALK5] and activin receptor type IIB [ActRIIB]) in endometrium of healthy women during menstrual cycle as well as in benign (endometriosis, polyps) and ..
  7. Li A, Hanchard N, Azamian M, D Alessandro L, Coban Akdemir Z, Lopez K, et al. Genetic architecture of laterality defects revealed by whole exome sequencing. Eur J Hum Genet. 2019;27:563-573 pubmed publisher
    ..deletions) were identified, including variants in genes known to cause heterotaxy and primary ciliary dyskinesia (ACVR2B, NODAL, ZIC3, DNAI1, DNAH5, HYDIN, MMP21), and genes without a human phenotype association, but with prior ..
  8. Chen J, Walton K, Al Musawi S, Kelly E, Qian H, La M, et al. Development of novel activin-targeted therapeutics. Mol Ther. 2015;23:434-44 pubmed publisher
    Soluble activin type II receptors (ActRIIA/ActRIIB), via binding to diverse TGF-β proteins, can increase muscle and bone mass, correct anemia or protect against diet-induced obesity...
  9. Morrison P, Bing C, Harris P, Maltin C, Grove White D, Argo C. Preliminary investigation into a potential role for myostatin and its receptor (ActRIIB) in lean and obese horses and ponies. PLoS ONE. 2014;9:e112621 pubmed publisher
    ..This study evaluated gene and protein expression of myostatin and its receptor, ActRIIB in adipose tissues and skeletal muscles and serum myostatin concentrations in six lean and six obese animals to ..
  10. Thulluru H, Michel O, Oudejans C, van Dijk M. ACVR2A promoter polymorphism rs1424954 in the Activin-A signaling pathway in trophoblasts. Placenta. 2015;36:345-9 pubmed publisher
    ..this effect is no longer seen, and we show this is potentially caused by a lack of downregulation of ACVR2B. The combined data suggest a double hit phenomenon in which the first hit, the promoter variant, together with the ..
  11. Toledo M, Busquets S, Penna F, Zhou X, Marmonti E, Betancourt A, et al. Complete reversal of muscle wasting in experimental cancer cachexia: Additive effects of activin type II receptor inhibition and β-2 agonist. Int J Cancer. 2016;138:2021-9 pubmed publisher
    ..The aim of this investigation was to evaluate the effects of a combination of the soluble myostatin receptor ActRIIB (sActRIIB) and the β2-agonist formoterol in the cachectic Lewis lung carcinoma model...
  12. Gerber M, Underwood P, Judge S, Delitto D, Delitto A, Nosacka R, et al. Local and Systemic Cytokine Profiling for Pancreatic Ductal Adenocarcinoma to Study Cancer Cachexia in an Era of Precision Medicine. Int J Mol Sci. 2018;19: pubmed publisher
    ..Both PDX groups had increased atrophy related gene expression in muscle compared to control (FoxO1, Socs3, STAT3, Acvr2b, Atrogin-1, MuRF1; P < 0.05)...
  13. Walsh S, Metter E, Ferrucci L, Roth S. Activin-type II receptor B (ACVR2B) and follistatin haplotype associations with muscle mass and strength in humans. J Appl Physiol (1985). 2007;102:2142-8 pubmed
    ..Follistatin and activin-type II receptor B (ACVR2B) are two myostatin-related genes involved in the regulation and signaling of myostatin...
  14. Chang H, Fang L, Cheng J, Klausen C, Sun Y, Leung P. Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells. Mol Cell Endocrinol. 2015;404:82-90 pubmed publisher
    ..Knockdown of ALK5, ACVR2A/ACVR2B or SMAD4 reversed the effects of GDF8-induced PTX3 suppression...
  15. Zhang S, Zuo C, Li W, Fu X, Xing S, Zhang X. Identification of key genes associated with the effect of estrogen on ovarian cancer using microarray analysis. Arch Gynecol Obstet. 2016;293:421-7 pubmed publisher
    ..In total, 465 DEGs were identified. Functional enrichment analysis of DEGs indicated that ACVR2B, LTBP1, BMP7 and MYC involved in TGF-beta signaling pathway. The 2285 DCG pairs and 357 DRGs were identified...
  16. Nadjar Boger E, Krol E, Funkenstein B. Two Activin Type 2B Receptors from Sea Bream Function Similarly in vitro. Biol Bull. 2016;230:56-67 pubmed
    ..Both signal through the activin type II receptors (ActRII and ActRIIB)...
  17. Nicolas N, Michel V, Bhushan S, Wahle E, Hayward S, Ludlow H, et al. Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice. Sci Rep. 2017;7:42391 pubmed publisher
    ..whereas mRNA expression of the inhibin B subunits (Inha and Inhbb) and activin receptor subunits (Acvr1b and Acvr2b) were downregulated...
  18. El Magd M, Ghoniem A, Helmy N, Abdelfattah Hassan A, Saleh A, Abd Allah E, et al. Effect of myostatin inhibitor (myostatin pro-peptide) microinjection on in vitro maturation and subsequent early developmental stages of buffalo embryo. Theriogenology. 2019;126:230-238 pubmed publisher
    ..of MSTNP was verified by upregulated expression of MSTNP and downregulated expression of the TGFβ receptor ActRIIb, the TGFβ signal transducer SMAD2 in COCs using qPCR...
  19. Baán J, Varga Z, Leszek P, Kuśmierczyk M, Baranyai T, Dux L, et al. Myostatin and IGF-I signaling in end-stage human heart failure: a qRT-PCR study. J Transl Med. 2015;13:1 pubmed publisher
    ..of Mstn and IGF-I signaling was carried out by measuring expression of Mstn, its receptor Activin receptor IIB (ActRIIB), IGF-I, IGF-I receptor (IGF-IR), and the negative regulator of Mstn miR-208, respectively...
  20. Wu R, Sedlmeier G, Kyjacova L, Schmaus A, Philipp J, Thiele W, et al. Hyaluronic acid-CD44 interactions promote BMP4/7-dependent Id1/3 expression in melanoma cells. Sci Rep. 2018;8:14913 pubmed publisher
    ..Co-IP experiments demonstrated that CD44 can physically associate with the BMP type II receptor (BMPR) ACVR2B. Importantly, we found that coordinate expression of Id1 or Id3 with HA synthases HAS2, HAS3, and CD44 is ..
  21. Amthor H, Hoogaars W. Interference with myostatin/ActRIIB signaling as a therapeutic strategy for Duchenne muscular dystrophy. Curr Gene Ther. 2012;12:245-59 pubmed
    Since the discovery of the myostatin/ActRIIB signaling pathway 15 years ago, numerous strategies were developed to block its inhibitory function during skeletal muscle growth...
  22. Song R, Catchpoole D, Kennedy P, Li J. Identification of lung cancer miRNA-miRNA co-regulation networks through a progressive data refining approach. J Theor Biol. 2015;380:271-9 pubmed publisher
    ..An example of these functional modules consists of genes SMAD2, ACVR1B, ACVR2A and ACVR2B. This module is synergistically regulated by let-7a/b/c/f, is enriched in the same GO category, and has a close ..
  23. Yoon J, Hwang S, Kim E, Jin M, Kim S, Hyun S. GDF8 activates p38 MAPK signaling during porcine oocyte maturation in vitro. Theriogenology. 2017;101:123-134 pubmed publisher
    ..Supplementation with GDF8 during IVM induced transcription of specific TGF-β receptor genes, such as ActRIIb and Alk4/5, and the recognition of the GDF8 by these receptors induced phosphorylation of p38 MAPK...
  24. Koszinowski S, Buss K, Kaehlcke K, Krieglstein K. Signaling via the transcriptionally regulated activin receptor 2B is a novel mediator of neuronal cell death during chicken ciliary ganglion development. Int J Dev Neurosci. 2015;41:98-104 pubmed publisher
    ..We show that the expression of ACVR2B, coding for the ActRIIB, is tightly regulated during CG development and the knockdown of ACVR2B expression leads to a deregulation in the ..
  25. Lowery J, Intini G, Gamer L, Lotinun S, Salazar V, Ote S, et al. Loss of BMPR2 leads to high bone mass due to increased osteoblast activity. J Cell Sci. 2015;128:1308-15 pubmed publisher
    ..The type 2 receptors ACVR2A and ACVR2B bind BMPs and activins but the type 2 receptor BMPR2 only binds BMPs, suggesting that type 2 receptor utilization ..
  26. Lim R, Muljadi R, Koulaeva E, Vosdoganes P, Chan S, Acharya R, et al. Activin A contributes to the development of hyperoxia-induced lung injury in neonatal mice. Pediatr Res. 2015;77:749-56 pubmed publisher
    ..The pups were administered activin A receptor type IIB-Fc antagonist (ActRIIB-Fc) at 5 mg/kg or follistatin at 0.1 mg/kg on postnatal days 4, 7, 10, and 13...
  27. Wu H, Wang H, Liu M, Bai Y, Li Y, Ji L, et al. MiR-195 participates in the placental disorder of preeclampsia via targeting activin receptor type-2B in trophoblastic cells. J Hypertens. 2016;34:1371-9 pubmed publisher
    ..Bioinformatic analysis predicted a type II activin receptor, activin receptor type-2B (ActRIIB), as one of the potential targets of miR-195...
  28. Olsen O, Sankar M, Elsaadi S, Hella H, Buene G, Darvekar S, et al. BMPR2 inhibits activin and BMP signaling via wild-type ALK2. J Cell Sci. 2018;131: pubmed publisher
    ..BMPR2 inhibits ALK2-mediated signaling by preventing ALK2 from oligomerizing with the type 2 receptors ACVR2A and ACVR2B, which are necessary for activation of ALK2 by activins and several BMPs...
  29. Magrey M, HAQQI T, Haseeb A. Identification of plasma microRNA expression profile in radiographic axial spondyloarthritis-a pilot study. Clin Rheumatol. 2016;35:1323-7 pubmed publisher
    ..The most repressed miRNA was miR-16 and is predicted to regulate the expression of activin A receptor (ACVR2B), a receptor for growth, and differentiation factor-5 (GDF-5)...
  30. Parker L, Caldow M, Watts R, Levinger P, Cameron Smith D, Levinger I. Age and sex differences in human skeletal muscle fibrosis markers and transforming growth factor-β signaling. Eur J Appl Physiol. 2017;117:1463-1472 pubmed publisher
    ..05). Gene expression of ActRIIB, myostatin, and TGF-β1 were higher in older adults compared to younger adults (all p < 0.05)...
  31. Attisano L, Wrana J, Montalvo E, Massague J. Activation of signalling by the activin receptor complex. Mol Cell Biol. 1996;16:1066-73 pubmed
    ..The evidence suggests that ActR-IIB acts as a primary activin receptor and ActR-IB acts as a downstream transducer of activin signals. ..
  32. Shabanpoor F, McClorey G, Saleh A, Järver P, Wood M, Gait M. Bi-specific splice-switching PMO oligonucleotides conjugated via a single peptide active in a mouse model of Duchenne muscular dystrophy. Nucleic Acids Res. 2015;43:29-39 pubmed publisher
    ..for simultaneous delivery and pre-mRNA targeting of two separate genes, exon 23 of the Dmd gene and exon 5 of the Acvr2b gene, in a mouse model of Duchenne muscular dystrophy...
  33. Lee Y, Lehar A, Sebald S, Liu M, Swaggart K, Talbot C, et al. Muscle hypertrophy induced by myostatin inhibition accelerates degeneration in dysferlinopathy. Hum Mol Genet. 2015;24:5711-9 pubmed publisher
    ..follistatin in skeletal muscle or by systemic administration of the soluble form of the activin type IIB receptor (ACVR2B/Fc)...
  34. Canali S, Core A, Zumbrennen Bullough K, Merkulova M, Wang C, Schneyer A, et al. Activin B Induces Noncanonical SMAD1/5/8 Signaling via BMP Type I Receptors in Hepatocytes: Evidence for a Role in Hepcidin Induction by Inflammation in Male Mice. Endocrinology. 2016;157:1146-62 pubmed publisher
    ..Activin B stimulates hepcidin via classical activin type II receptors ACVR2A and ACVR2B, noncanonical BMP type I receptors activin receptor-like kinase 2 and activin receptor-like kinase 3, and SMAD5...
  35. Goh B, Singhal V, Herrera A, Tomlinson R, Kim S, Faugere M, et al. Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass. J Biol Chem. 2017;292:13809-13822 pubmed publisher
    ..Here, we generated mice with conditional deletion of activin receptor (ACVR) type 2A, ACVR2B, or both, in osteoblasts, to determine the contribution of activin receptor signaling in regulating bone mass...
  36. Voglmeir J, Laurent N, Flitsch S, Oelgeschläger M, Wilson I. Biological and biochemical properties of two Xenopus laevis N-acetylgalactosaminyltransferases with contrasting roles in embryogenesis. Comp Biochem Physiol B Biochem Mol Biol. 2015;180:40-7 pubmed publisher
  37. Liang G, Zhang X, Wang J, Sun Y, Sun X, Cheng S, et al. Activin A accelerates the progression of fetal oocytes throughout meiosis and early oogenesis in the mouse. Stem Cells Dev. 2015;24:2455-65 pubmed publisher
    ..In this study, we reported that activin receptors (including ActRIA, ActRIB, ActRIIA, and ActRIIB) are expressed throughout the development of the mouse ovaries from 12...
  38. Cheewasopit W, Laird M, Glister C, Knight P. Myostatin is expressed in bovine ovarian follicles and modulates granulosal and thecal steroidogenesis. Reproduction. 2018;: pubmed publisher
    ..Here, we first examined relative expression of myostatin (MSTN), myostatin receptors (ACVR1B, ACVR2B and TGFBR1) and binding protein, follistatin (FST), in granulosa (GC) and theca (TC) cells of developing bovine ..
  39. Bernstein L, Mackenzie A, Lee S, Chaffin C, Merchenthaler I. Activin Decoy Receptor ActRIIB:Fc Lowers FSH and Therapeutically Restores Oocyte Yield, Prevents Oocyte Chromosome Misalignments and Spindle Aberrations, and Increases Fertility in Midlife Female SAMP8 Mice. Endocrinology. 2016;157:1234-47 pubmed publisher
    ..Activin is a molecule that raises FSH, and ActRIIB:Fc is an activin decoy receptor that binds and sequesters activin...
  40. Dalbo V, Roberts M, Mobley C, Ballmann C, Kephart W, Fox C, et al. Testosterone and trenbolone enanthate increase mature myostatin protein expression despite increasing skeletal muscle hypertrophy and satellite cell number in rodent muscle. Andrologia. 2017;49: pubmed publisher
    ..043), although there were no between-treatment effects regarding phosphorylated SMAD2/3. Mstn, ActrIIb and Mighty mRNAs were lower in ORX, ORX + TEST and ORX + TREN compared to SHAM (p < .05)...
  41. Winbanks C, Murphy K, Bernardo B, Qian H, Liu Y, Sepulveda P, et al. Smad7 gene delivery prevents muscle wasting associated with cancer cachexia in mice. Sci Transl Med. 2016;8:348ra98 pubmed publisher
    ..Excessive activation of the type IIB activin receptor (ActRIIB) is considered an important mechanism underlying this wasting, where circulating procachectic factors bind ..
  42. Guru Vishnu P, Bhattacharya T, Kumar P, Chaterjee R, Ravi Kumar G, Paswan C, et al. Expression Profiling of Activin type IIB Receptor During Ontogeny in Broiler and Indigenous Chicken. Anim Biotechnol. 2017;28:26-36 pubmed publisher
    ..Activin type IIB receptor (ACTRIIB) has been reported to play vital role in the negative regulation of muscle growth by binding to multiple members ..
  43. Tang L, Zhang J, Zhao X, Li N, Jian W, Sun S, et al. Low-Intensity Pulsed Ultrasound Promotes Exercise-Induced Muscle Hypertrophy. Ultrasound Med Biol. 2017;43:1411-1420 pubmed publisher
    ..upregulated the expression of Akt, mTOR, p-Akt and p-mTOR and significantly downregulated the expression of MSTN, ActRIIB, FoxO1 and its phosphorylation...
  44. Aykul S, Martinez Hackert E. Transforming Growth Factor-β Family Ligands Can Function as Antagonists by Competing for Type II Receptor Binding. J Biol Chem. 2016;291:10792-804 pubmed publisher
    ..Based on the observation that the type II TGF-β family receptors ActRIIA, ActRIIB, and BMPRII interact with a large group of overlapping ligands at overlapping epitopes, we hypothesized high ..
  45. Ding H, Zhang G, Sin K, Liu Z, Lin R, Li M, et al. Activin A induces skeletal muscle catabolism via p38? mitogen-activated protein kinase. J Cachexia Sarcopenia Muscle. 2017;8:202-212 pubmed publisher
    Activation of type IIB activin receptor (ActRIIB) in skeletal muscle leads to muscle atrophy because of increased muscle protein degradation...
  46. Samant S, Kanwal A, Pillai V, Bao R, Gupta M. The histone deacetylase SIRT6 blocks myostatin expression and development of muscle atrophy. Sci Rep. 2017;7:11877 pubmed publisher
    ..We also observed upregulation of other factors implicated in muscle atrophy, such as angiotensin-II, activin and Acvr2b, in SIRT6 depleted cells...
  47. Parks W, Frank D, Huff C, Renfrew Haft C, Martin J, Meng X, et al. Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. J Biol Chem. 2001;276:19332-9 pubmed
    ..Of the type II receptors, SNX6 was found to interact strongly with ActRIIB and more moderately with wild type and kinase-defective mutants of TbetaRII...
  48. Focà A, Sanguigno L, Focà G, Strizzi L, Iannitti R, Palumbo R, et al. New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding. Int J Mol Sci. 2015;16:21342-62 pubmed publisher
    Nodal is a potent embryonic morphogen belonging to the TGF-β superfamily. Typically, it also binds to the ALK4/ActRIIB receptor complex in the presence of the co-receptor Cripto-1...
  49. Wang Y, Wang X, Wohland T, Sampath K. Extracellular interactions and ligand degradation shape the nodal morphogen gradient. elife. 2016;5: pubmed publisher
    ..measured in vivo for the first time, the binding affinity of Nodal ligands to their major cell surface receptor, Acvr2b, and to the Nodal inhibitor, Lefty, by fluorescence cross-correlation spectroscopy...
  50. Seher A, Lagler C, Stühmer T, Müller Richter U, Kübler A, Sebald W, et al. Utilizing BMP-2 muteins for treatment of multiple myeloma. PLoS ONE. 2017;12:e0174884 pubmed publisher
    ..are counteracted by Activin A, we analysed whether BMP2, which also binds to the Activin A receptors ActRII and ActRIIB but activates the alternative SMAD-1/5/8 pathway, can be used to antagonize Activin A activities, such as in the ..
  51. Wei F, Liu D, Feng C, Zhang F, Yang S, Hu Y, et al. microRNA-21 mediates stretch-induced osteogenic differentiation in human periodontal ligament stem cells. Stem Cells Dev. 2015;24:312-9 pubmed publisher
    ..Furthermore, we identified activin receptor type IIB (ACVR2B) as a target gene of miR-21...
  52. Song G, Wang R, Guo J, Liu X, Wang F, Qi Y, et al. miR-346 and miR-138 competitively regulate hTERT in GRSF1- and AGO2-dependent manners, respectively. Sci Rep. 2015;5:15793 pubmed publisher
    ..Moreover, miR-346 depends on GRSF1 to upregulate another target gene, activin A receptor, type IIB (ACVR2B), in which miR-346 "CCGCAU" motif is essential...
  53. Klimentidis Y, Bea J, Thompson P, Klimecki W, Hu C, Wu G, et al. Genetic Variant in ACVR2B Is Associated with Lean Mass. Med Sci Sports Exerc. 2016;48:1270-5 pubmed publisher
    ..In the replication stage, we find that SNP rs2276541 in the activin A receptor, type IIB (ACVR2B), was significantly associated with LM (β = 0.15, P = 2.17 × 10)...
  54. Pan C, Singh S, Sahasrabudhe D, Chakkalakal J, Krolewski J, Nastiuk K. TGF? Superfamily Members Mediate Androgen Deprivation Therapy-Induced Obese Frailty in Male Mice. Endocrinology. 2016;157:4461-4472 pubmed
    ..Sarcopenia onset occurred about 6 weeks after castration and was blocked by a soluble receptor (ActRIIB-Fc) that binds multiple TGF? superfamily members, including myostatin, growth differentiation factor 11, activin ..
  55. Maricelli J, Bishaw Y, Wang B, Du M, Rodgers B. Systemic SMAD7 Gene Therapy Increases Striated Muscle Mass and Enhances Exercise Capacity in a Dose-Dependent Manner. Hum Gene Ther. 2017;: pubmed publisher
    ..This is accomplished by attenuating ActRIIb intracellular signaling and, as a result, the physiological actions of myostatin and other ActRIIb ligands...
  56. Yamakawa N, Tsuchida K, Sugino H. The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors. EMBO J. 2002;21:1684-94 pubmed
    ..These findings indicate that Dok-1 acts as an adaptor protein that links the activin receptors with the Smads, suggesting a novel function for Dok-1 in activin signaling leading to B-cell apoptosis. ..
  57. Galvão A, Skarzynski D, Ferreira Dias G. Nodal Promotes Functional Luteolysis via Down-Regulation of Progesterone and Prostaglandins E2 and Promotion of PGF2α Synthetic Pathways in Mare Corpus Luteum. Endocrinology. 2016;157:858-71 pubmed publisher
    ..Expression pattern of Nodal and its receptors activin receptor A type IIB (ACVR2B), activin receptor-like kinase (Alk)-7, and Alk4, as well as the Nodal physiological role, demonstrate the ..
  58. Looney A, Ahearne C, Hallberg B, Boylan G, Murray D. Downstream mRNA Target Analysis in Neonatal Hypoxic-Ischaemic Encephalopathy Identifies Novel Marker of Severe Injury: a Proof of Concept Paper. Mol Neurobiol. 2017;54:8420-8428 pubmed publisher
    ..targets of this microRNA (miRNA) are unclear, but one putative target is the activin-A receptor type IIb (ACVR2B)...
  59. Hu M, Cui F, Liu F, Wang J, Wei X, Li Y. BMP signaling pathways affect differently migration and invasion of esophageal squamous cancer cells. Int J Oncol. 2017;50:193-202 pubmed publisher
    ..BMP6 and type I receptor ALK2 and type II receptor BMPRII, ActRIIA and ActRIIB were expressed in all ESCC cell lines...
  60. de Winter J, de Vries C, van Achterberg T, Ameerun R, Feijen A, Sugino H, et al. Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors. Exp Cell Res. 1996;224:323-34 pubmed
    ..Furthermore, our data indicate that truncated type IIA receptors can interact with other type I receptors and as such might inhibit signal transduction by type I receptors other than activin type IA and type IB receptors. ..
  61. Tinklenberg J, Meng H, Yang L, Liu F, Hoffmann R, Dasgupta M, et al. Treatment with ActRIIB-mFc Produces Myofiber Growth and Improves Lifespan in the Acta1 H40Y Murine Model of Nemaline Myopathy. Am J Pathol. 2016;186:1568-81 pubmed publisher
    ..We have used i.p. injection of activin type IIB receptor (ActRIIB)-mFc (an inhibitor of myostatin signaling) to promote hypertrophy and increase strength in our prior murine work; ..
  62. Barreto R, Waning D, Gao H, Liu Y, Zimmers T, Bonetto A. Chemotherapy-related cachexia is associated with mitochondrial depletion and the activation of ERK1/2 and p38 MAPKs. Oncotarget. 2016;7:43442-43460 pubmed publisher
    ..Finally, ACVR2B/Fc or PD98059 prevented Folfiri-associated ERK1/2 activation and myofiber atrophy in C2C12 cultures...
  63. Dillenburg A, Ireland G, Holloway R, Davies C, Evans F, Swire M, et al. Activin receptors regulate the oligodendrocyte lineage in health and disease. Acta Neuropathol. 2018;135:887-906 pubmed publisher
    ..During efficient myelin regeneration, Acvr2a upregulation was seen to coincide with downregulation of Acvr2b, a receptor subtype with relatively higher ligand affinity; Acvr2b was shown to be dispensable for activin ..
  64. Bondestam J, Horelli Kuitunen N, Hilden K, Ritvos O, Aaltonen J. Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-->q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH. Cytogenet Cell Genet. 1999;87:219-20 pubmed
  65. Lux A, Beil C, Majety M, Barron S, Gallione C, Kuhn H, et al. Human retroviral gag- and gag-pol-like proteins interact with the transforming growth factor-beta receptor activin receptor-like kinase 1. J Biol Chem. 2005;280:8482-93 pubmed
    ..This is the first report of a human retroviral-like protein interacting with members of the TGF-beta receptor family. ..
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    ..Both ligands bind and activate ActRIIB receptors with similar affinities and should therefore have similar actions, yet these studies suggest that GDF11 ..
  67. Kornegay J, Bogan D, Bogan J, Dow J, Wang J, Fan Z, et al. Dystrophin-deficient dogs with reduced myostatin have unequal muscle growth and greater joint contractures. Skelet Muscle. 2016;6:14 pubmed publisher
    ..Activin receptor type IIB (ActRIIB) expression was higher in dystrophic versus control dogs, consistent with physiologic feedback between myostatin ..
  68. Miller M, Lambert Messerlian G, Eklund E, Heath N, Donahue J, Stopa E. Expression of inhibin/activin proteins and receptors in the human hypothalamus and basal forebrain. J Neuroendocrinol. 2012;24:962-72 pubmed publisher
    ..These studies show for the first time that the inhibin/activin protein subunits and receptors can be co-localised in the human brain, implicating potential, diverse neural functions. ..
  69. Babcock L, Knoblauch M, Clarke M. The role of myostatin and activin receptor IIB in the regulation of unloading-induced myofiber type-specific skeletal muscle atrophy. J Appl Physiol (1985). 2015;119:633-42 pubmed publisher
    ..Myostatin must first be secreted into the circulation and then bind to the membrane-bound activin receptor IIB (actRIIB) to exert its atrophic action...
  70. Puolakkainen T, Ma H, Kainulainen H, Pasternack A, Rantalainen T, Ritvos O, et al. Treatment with soluble activin type IIB-receptor improves bone mass and strength in a mouse model of Duchenne muscular dystrophy. BMC Musculoskelet Disord. 2017;18:20 pubmed publisher
    ..divided to running and non-running groups and to receive either PBS control or soluble activin type IIB-receptor (ActRIIB-Fc) once weekly for 7 weeks...
  71. Wu F, Lin T, Sung L, Chang W, Wu P, Luo C. BMP8A sustains spermatogenesis by activating both SMAD1/5/8 and SMAD2/3 in spermatogonia. Sci Signal. 2017;10: pubmed publisher
    ..by ALK3 and either ACVR2A or BMPR2 and activated SMAD2/3 through receptor complexes formed by ALK5 and ACVR2A, ACVR2B, or TGFBR2...
  72. Yoo D, Kim K, Kim H, Cho S, Kim J, Lim D, et al. The Genetic Origin of Short Tail in Endangered Korean Dog, DongGyeongi. Sci Rep. 2017;7:10048 pubmed publisher
    ..Moreover, this study suggested that selective sweep genes, ANKRD11 and ACVR2B may contribute to the reduction in tail length, and non-synonymous variant in the coding sequence of T gene and ..
  73. Harrison C, Gray P, Fischer W, Donaldson C, Choe S, Vale W. An activin mutant with disrupted ALK4 binding blocks signaling via type II receptors. J Biol Chem. 2004;279:28036-44 pubmed
    ..Indeed, the M108A mutant antagonized activin-A and myostatin, but not TGF-beta, signaling in 293T cells, indicating it may be generally capable of blocking ligands that signal via ActRII/IIB. ..
  74. Xia Y, Babitt J, Sidis Y, Chung R, Lin H. Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin. Blood. 2008;111:5195-204 pubmed publisher
    ..We demonstrate in vitro that HJV selectively uses the BMP type II receptors ActRIIA and BMPRII, but not ActRIIB, and HJV enhances utilization of ActRIIA by BMP-2 and BMP-4...
  75. Lavery K, Swain P, Falb D, Alaoui Ismaili M. BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. J Biol Chem. 2008;283:20948-58 pubmed publisher
    ..BMPR1B and ACVR2B were expressed at low levels and were not found to play a significant role in signaling by any of the BMPs ..
  76. Hulmi J, Nissinen T, Räsänen M, Degerman J, Lautaoja J, Hemanthakumar K, et al. Prevention of chemotherapy-induced cachexia by ACVR2B ligand blocking has different effects on heart and skeletal muscle. J Cachexia Sarcopenia Muscle. 2017;: pubmed publisher
    ..Blocking of activin receptor type IIB (ACVR2B) ligands is an often used strategy to prevent skeletal muscle loss, but its effects on the heart are relatively ..
  77. Nishitoh H, Ichijo H, Kimura M, Matsumoto T, Makishima F, Yamaguchi A, et al. Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. J Biol Chem. 1996;271:21345-52 pubmed
    ..These results suggest that BMPR-IB mediates certain signals for GDF-5 after forming the heteromeric complex with BMPR-II or ActR-II. ..
  78. Willis S, Zimmerman C, Li L, Mathews L. Formation and activation by phosphorylation of activin receptor complexes. Mol Endocrinol. 1996;10:367-79 pubmed
    ..Taken together, these results support a role for phosphorylation of type I ActRs in the generation of a biological signal. ..
  79. Ishikawa S, Kai M, Murata Y, Tamari M, Daigo Y, Murano T, et al. Genomic organization and mapping of the human activin receptor type IIB (hActR-IIB) gene. J Hum Genet. 1998;43:132-4 pubmed
    ..3, we found the gene encoding activin receptor type IIB (hActR-IIB). Comparison of its reported cDNA sequence with this genomic sequence showed that the hActR-IIB gene consists of 11 exons and spans about 30 kb of genomic DNA. ..
  80. Han S. Crystal structure of activin receptor type IIB kinase domain. Vitam Horm. 2011;85:29-38 pubmed publisher
    Activin receptor type IIB (ActRIIB) belongs to a type II transforming growth factor-? (TGF-?) serine/threonine kinase receptor family which is integral to the activin and myostatin signaling pathway...
  81. Dieli Conwright C, Spektor T, Rice J, Sattler F, Schroeder E. Hormone therapy and maximal eccentric exercise alters myostatin-related gene expression in postmenopausal women. J Strength Cond Res. 2012;26:1374-82 pubmed publisher
    ..was determined using reverse transcriptase polymerase chain reaction for myostatin, activin receptor IIb (ActRIIb), follistatin, follistatin-related gene (FLRG), follistatin-like-3 (FSTL3), and GDF serum-associated protein-1 (..
  82. Olsen O, Wader K, Hella H, Mylin A, Turesson I, Nesthus I, et al. Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B. Cell Commun Signal. 2015;13:27 pubmed publisher
    ..Activin A was able to counteract BMPs that signal through the type 2 receptors ACVR2A and ACVR2B in combination with ALK2, but not BMPs that signal through BMPR2 in combination with ALK3 and ALK6...
  83. Choi K, Kang S, Nathwani P, Cheng K, Auersperg N, Leung P. Differential expression of activin/inhibin subunit and activin receptor mRNAs in normal and neoplastic ovarian surface epithelium (OSE). Mol Cell Endocrinol. 2001;174:99-110 pubmed
  84. Kamiya Y, Miyazono K, Miyazawa K. Smad7 inhibits transforming growth factor-beta family type i receptors through two distinct modes of interaction. J Biol Chem. 2010;285:30804-13 pubmed publisher
    ..Smad7 thus has an additional mode of interaction with TGF-? family type I receptors not possessed by Smad6, which may play roles in mediating the inhibitory effects unique to Smad7. ..
  85. Martens J, de Winter J, Timmerman M, McLuskey A, van Schaik R, Themmen A, et al. Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells. Endocrinology. 1997;138:2928-36 pubmed
    ..In conclusion, these data show that in Chinese hamster ovary cells inhibin acts directly at the activin receptor complex, most likely through displacement of activin from the activin type II receptor. ..
  86. Chapman S, Woodruff T. Modulation of activin signal transduction by inhibin B and inhibin-binding protein (INhBP). Mol Endocrinol. 2001;15:668-79 pubmed
    ..These findings suggest that InhBP is an inhibin B-specific receptor that mediates antagonism of activin signal transduction through the modulation of activin heteromeric receptor complex assembly. ..
  87. Bayarsaikhan O, Kawai N, Mori H, Kinouchi N, Nikawa T, Tanaka E. Co-Administration of Myostatin-Targeting siRNA and ActRIIB-Fc Fusion Protein Increases Masseter Muscle Mass and Fiber Size. J Nutr Sci Vitaminol (Tokyo). 2017;63:244-248 pubmed publisher
    ..skeletal muscle cell growth and differentiation, and binds with high affinity to the activin type IIB receptor (ActRIIB)...
  88. Ebisawa T, Tada K, Kitajima I, Tojo K, Sampath T, Kawabata M, et al. Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation. J Cell Sci. 1999;112 ( Pt 20):3519-27 pubmed
    ..These findings indicate that in the process of differentiation to osteoblasts, BMP-6 binds to ALK-2 as well as other type I receptors, and transduces signals mainly through Smad5 and possibly through Smad1. ..
  89. Rebbapragada A, Benchabane H, Wrana J, Celeste A, Attisano L. Myostatin signals through a transforming growth factor beta-like signaling pathway to block adipogenesis. Mol Cell Biol. 2003;23:7230-42 pubmed
    ..We showed that myostatin binds the type II Ser/Thr kinase receptor. ActRIIB, and then partners with a type I receptor, either activin receptor-like kinase 4 (ALK4 or ActRIB) or ALK5 (..
  90. Keller S, Nickel J, Zhang J, Sebald W, Mueller T. Molecular recognition of BMP-2 and BMP receptor IA. Nat Struct Mol Biol. 2004;11:481-8 pubmed
    ..Thus, the L51P substitution converts BMP-2 into a receptor-inactive inhibitor of noggin. These results are relevant for other proteins of the TGF-beta superfamily and provide useful clues for structure-based drug design. ..
  91. Senanayake U, Das S, Vesely P, Alzoughbi W, Fröhlich L, Chowdhury P, et al. miR-192, miR-194, miR-215, miR-200c and miR-141 are downregulated and their common target ACVR2B is strongly expressed in renal childhood neoplasms. Carcinogenesis. 2012;33:1014-21 pubmed publisher
    ..In this study, the activin receptor type 2B (ACVR2B), a member of the transforming growth factor (TGF)-? pathway, was identified as single common ..
  92. Béchir N, Pecchi E, Vilmen C, Le Fur Y, Amthor H, Bernard M, et al. ActRIIB blockade increases force-generating capacity and preserves energy supply in exercising mdx mouse muscle in vivo. FASEB J. 2016;30:3551-3562 pubmed
    Postnatal blockade of the activin type IIB receptor (ActRIIB) represents a promising therapeutic strategy for counteracting dystrophic muscle wasting...