ACVR1B

Summary

Gene Symbol: ACVR1B
Description: activin A receptor type 1B
Alias: ACTRIB, ACVRLK4, ALK4, SKR2, activin receptor type-1B, activin A receptor, type IB, activin A receptor, type II-like kinase 4, activin receptor-like kinase 4, serine/threonine-protein kinase receptor R2
Species: human
Products:     ACVR1B

Top Publications

  1. Wang Q, Huang Z, Xue H, Jin C, Ju X, Han J, et al. MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4. Blood. 2008;111:588-95 pubmed
    ..that miR-24 regulates erythroid differentiation by influencing the expression of human activin type I receptor ALK4 (hALK4)...
  2. Attisano L, Wrana J, Montalvo E, Massague J. Activation of signalling by the activin receptor complex. Mol Cell Biol. 1996;16:1066-73 pubmed
    ..The evidence suggests that ActR-IIB acts as a primary activin receptor and ActR-IB acts as a downstream transducer of activin signals. ..
  3. Su G, Bansal R, Murphy K, Montgomery E, Yeo C, Hruban R, et al. ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma. Proc Natl Acad Sci U S A. 2001;98:3254-7 pubmed
    ..Here we describe the gene structure and novel somatic mutations of the activin type I receptor, ACVR1B, in pancreatic cancer. ACVR1B has not been described previously as a mutated tumor-suppressor gene.
  4. Yeo C, Whitman M. Nodal signals to Smads through Cripto-dependent and Cripto-independent mechanisms. Mol Cell. 2001;7:949-57 pubmed
    ..We find that Cripto interacts with the type I receptor ALK4 via the conserved CFC motif in Cripto...
  5. Bianco C, Adkins H, Wechselberger C, Seno M, Normanno N, De Luca A, et al. Cripto-1 activates nodal- and ALK4-dependent and -independent signaling pathways in mammary epithelial Cells. Mol Cell Biol. 2002;22:2586-97 pubmed
    ..Phage inserts with identity to ALK4, a type I serine/threonine kinase receptor for Activin, were identified...
  6. Yan Y, Liu J, Luo Y, E C, Haltiwanger R, Abate Shen C, et al. Dual roles of Cripto as a ligand and coreceptor in the nodal signaling pathway. Mol Cell Biol. 2002;22:4439-49 pubmed
    ..Our findings highlight the significance of extracellular modulation of ligand activity as an important means of regulating TGF beta signaling pathways during vertebrate development. ..
  7. Nadeem L, Munir S, Fu G, Dunk C, Baczyk D, Caniggia I, et al. Nodal signals through activin receptor-like kinase 7 to inhibit trophoblast migration and invasion: implication in the pathogenesis of preeclampsia. Am J Pathol. 2011;178:1177-89 pubmed publisher
    ..These findings suggest that the Nodal/ALK7 pathway plays important roles in human placentation and that its abnormal signaling may contribute to the development of preeclampsia. ..
  8. Chen J, Colgan T, Walton K, Gregorevic P, Harrison C. The TGF-? Signalling Network in Muscle Development, Adaptation and Disease. Adv Exp Med Biol. 2016;900:97-131 pubmed publisher
    ..In muscle, myostatin binds to its type I (ALK4/5) and type II (ActRIIA/B) receptors to initiate Smad2/3 signalling and the regulation of target genes that co-..
  9. Castro N, Rangel M, Merchant A, MacKinnon G, Cuttitta F, Salomon D, et al. Sulforaphane Suppresses the Growth of Triple-negative Breast Cancer Stem-like Cells In vitro and In vivo. Cancer Prev Res (Phila). 2019;12:147-158 pubmed publisher
    ..of CSCs in TNBC via Cripto-mediated pathway by either suppressing its expression and/or by inhibiting Cripto/Alk4 protein complex formation...

More Information

Publications146 found, 100 shown here

  1. Qiu W, Tang S, Lee S, Turk A, Sireci A, Qiu A, et al. Loss of Activin Receptor Type 1B Accelerates Development of Intraductal Papillary Mucinous Neoplasms in Mice With Activated KRAS. Gastroenterology. 2016;150:218-228.e12 pubmed publisher
    ..Human pancreatic ductal adenocarcinomas contain somatic mutations in the activin A receptor type IB (ACVR1B) gene, indicating that ACVR1B could be a suppressor of pancreatic tumorigenesis...
  2. Liu F, Ventura F, Doody J, Massague J. Human type II receptor for bone morphogenic proteins (BMPs): extension of the two-kinase receptor model to the BMPs. Mol Cell Biol. 1995;15:3479-86 pubmed
    ..The combinatorial nature of these receptors and their capacity to crosstalk with the activin receptor system may underlie the multifunctional nature of their ligands. ..
  3. Liang G, Zhang X, Wang J, Sun Y, Sun X, Cheng S, et al. Activin A accelerates the progression of fetal oocytes throughout meiosis and early oogenesis in the mouse. Stem Cells Dev. 2015;24:2455-65 pubmed publisher
    ..In this study, we reported that activin receptors (including ActRIA, ActRIB, ActRIIA, and ActRIIB) are expressed throughout the development of the mouse ovaries from 12...
  4. Yoon J, Hwang S, Kim E, Jin M, Kim S, Hyun S. GDF8 activates p38 MAPK signaling during porcine oocyte maturation in vitro. Theriogenology. 2017;101:123-134 pubmed publisher
    ..Supplementation with GDF8 during IVM induced transcription of specific TGF-β receptor genes, such as ActRIIb and Alk4/5, and the recognition of the GDF8 by these receptors induced phosphorylation of p38 MAPK...
  5. Focà G, Iaccarino E, Focà A, Sanguigno L, Untiveros G, Cuevas Nunez M, et al. Development of conformational antibodies targeting Cripto-1 with neutralizing effects in vitro. Biochimie. 2019;158:246-256 pubmed publisher
    ..hot spot" residues on the CFC domain, which are crucial for the interaction with Activin Type I receptor (ALK4) and GRP78...
  6. Li Y, Zhong W, Zhu M, Hu S, Su X. Nodal regulates bladder cancer cell migration and invasion via the ALK/Smad signaling pathway. Onco Targets Ther. 2018;11:6589-6597 pubmed publisher
    ..Knockdown of Nodal also blocked the expression of ALK4, ALK7, Smad2, and Smad4, which are involved in ALK/Smad signaling...
  7. Spender L, Ferguson G, Hughes G, Davies B, Goldberg F, Herrera B, et al. Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors. Mol Pharmacol. 2019;95:222-234 pubmed publisher
    ..AZ12601011 inhibited phosphorylation of SMAD2 via the type 1 receptors activin A receptor type 1B (ALK4), TGFBR1, and activin A receptor type 1C (ALK7)...
  8. Ribeiro A, Freitas C, Matos L, Gouveia A, Gomes F, Silva Carvalho J, et al. Age-related expression of TGF beta family receptors in human cumulus oophorus cells. J Assist Reprod Genet. 2017;34:1121-1129 pubmed publisher
    ..The findings indicate that reproductive aging affects the local regulation of signaling pathways mediated by BMPR2, ALK6, and ALK4 receptor activation, suggesting their joint involvement.
  9. Alam M, Takahashi R, Afify S, Oo A, Kumon K, Nawara H, et al. Exogenous Cripto-1 Suppresses Self-Renewal of Cancer Stem Cell Model. Int J Mol Sci. 2018;19: pubmed publisher
    ..miPS-LLCcm cells in a dose-dependent manner in the range of 0 to 5 µg/mL, due to the suppression of Nodal-Cripto-1/ALK4/Smad2 signaling pathway. Frequency of sphere-forming cells was dropped from 1/40 to 1/69 by rhsfCR-1 at 1 µg/mL...
  10. Chang H, Fang L, Cheng J, Klausen C, Sun Y, Leung P. Growth differentiation factor 8 down-regulates pentraxin 3 in human granulosa cells. Mol Cell Endocrinol. 2015;404:82-90 pubmed publisher
    ..suppressive effects, along with the induction of SMAD2/3 phosphorylation, were abolished by co-treatment with the ALK4/5/7 inhibitor SB431542...
  11. Tian R, Yang S, Zhu Z, Wang J, Liu Y, Yao C, et al. NODAL secreted by male germ cells regulates the proliferation and function of human Sertoli cells from obstructive azoospermia and nonobstructive azoospermia patients. Asian J Androl. 2015;17:996-1005 pubmed publisher
    ..NODAL was found to be expressed in male germ cells but not in Sertoli cells, whereas its receptors ALK4, ALK7, and ACTR-IIB were detected in Sertoli cells and germ cells, suggesting that NODAL plays a regulatory role in ..
  12. Lee B, Oh Y, Jo S, Kim T, Ji J. A dual role of TGF-β in human osteoclast differentiation mediated by Smad1 versus Smad3 signaling. Immunol Lett. 2019;206:33-40 pubmed publisher
    ..Inhibition of osteoclast differentiation by TGF-β1 was reversed by 1 μM SB431542 (an inhibitor of ALK4/5/7), which inhibited TGF-β1-induced phosphorylation of SMAD1, but not that of SMAD3...
  13. Nomura M, Morinaga H, Zhu H, Wang L, Hasuzawa N, Takayanagi R, et al. Activation of activin type IB receptor signals in pancreatic β cells leads to defective insulin secretion through the attenuation of ATP-sensitive K+ channel activity. Biochem Biophys Res Commun. 2014;450:440-6 pubmed publisher
    ..in pancreatic β cells, the Cre-loxP system was used to activate signaling through activin type IB receptor (ActRIB) in pancreatic β cells...
  14. Song R, Catchpoole D, Kennedy P, Li J. Identification of lung cancer miRNA-miRNA co-regulation networks through a progressive data refining approach. J Theor Biol. 2015;380:271-9 pubmed publisher
    ..An example of these functional modules consists of genes SMAD2, ACVR1B, ACVR2A and ACVR2B...
  15. Zhang H, Klausen C, Zhu H, Chang H, Leung P. BMP4 and BMP7 Suppress StAR and Progesterone Production via ALK3 and SMAD1/5/8-SMAD4 in Human Granulosa-Lutein Cells. Endocrinology. 2015;156:4269-80 pubmed publisher
    ..by pretreatment with inhibitors of activin receptor-like kinase (ALK)2/3/6 (dorsomorphin) or ALK2/3 (DMH1) but not ALK4/5/7 (SB-431542)...
  16. Li C, Chen Y, Wang Q, Hou J, Wang H, Wang Y, et al. Partial inhibition of activin receptor-like kinase 4 attenuates pressure overload-induced cardiac fibrosis and improves cardiac function. J Hypertens. 2016;34:1766-77 pubmed publisher
    Activin receptor-like kinase 4 (ALK4), a downstream receptor of transforming growth factor-β superfamily, is highly expressed in the mammal heart...
  17. Klauzinska M, Castro N, Rangel M, Spike B, Gray P, Bertolette D, et al. The multifaceted role of the embryonic gene Cripto-1 in cancer, stem cells and epithelial-mesenchymal transition. Semin Cancer Biol. 2014;29:51-8 pubmed publisher
    ..factor-β (TGF-β) family members, Nodal and growth and differentiation factors 1 and 3 (GDF1/3) by activating Alk4/Alk7 signaling pathways that involve Smads 2, 3 and 4...
  18. Suzuki H, Yaguchi S. Transforming growth factor-β signal regulates gut bending in the sea urchin embryo. Dev Growth Differ. 2018;60:216-225 pubmed publisher
    ..reevesii is likely regulated by these TGF-β members, as in other sea urchins. When the Alk4/5/7 signal was inhibited by its specific inhibitor, SB431542, before the late gastrula stage of T...
  19. Boueiz A, Pham B, Chase R, Lamb A, Lee S, Naing Z, et al. Integrative Genomics Analysis Identifies ACVR1B as a Candidate Causal Gene of Emphysema Distribution. Am J Respir Cell Mol Biol. 2018;: pubmed publisher
    ..Based on these analyses, we selected a variant near ACVR1B for functional validation...
  20. Casari A, Schiavone M, Facchinello N, Vettori A, Meyer D, Tiso N, et al. A Smad3 transgenic reporter reveals TGF-beta control of zebrafish spinal cord development. Dev Biol. 2014;396:81-93 pubmed publisher
    ..Moreover, Alk4 and Alk5 inhibitors strongly repress the reporter activity...
  21. Zhao J, Klausen C, Xiong S, Cheng J, Chang H, Leung P. Growth differentiation factor 8 induces SKOV3 ovarian cancer cell migration and E-cadherin down-regulation. Cell Signal. 2016;28:1615-22 pubmed publisher
    ..receptor-like kinase (ALK)4/5/7 inhibitor SB431542 or siRNA-mediated knockdown of ALK5, whereas knockdown of ALK4 is only partially inhibitory...
  22. Horvath L, Bodmer D, Radojevic V, Monge Naldi A. Activin signaling disruption in the cochlea does not influence hearing in adult mice. Audiol Neurootol. 2015;20:51-61 pubmed
    ..In this study, we present for the first time the presence of activin A and ActRIB in the adult cochlea...
  23. Peng J, Fullerton P, Monsivais D, Clementi C, Su G, Matzuk M. Uterine Activin-Like Kinase 4 Regulates Trophoblast Development During Mouse Placentation. Mol Endocrinol. 2015;29:1684-93 pubmed publisher
    ..of Nodal signaling in the uterus, we established a mouse model to conditionally ablate activin-like kinase 4 (ALK4; the Nodal type 1 receptor) using Cre recombinase driven by the progesterone receptor promoter sequences (Pgr-Cre)...
  24. Lee H, Seo G, Kim J, Lee M, Kim P. Activin A stimulates mouse macrophages to express APRIL via the Smad3 and ERK/CREB pathways. Immunol Lett. 2011;140:92-6 pubmed publisher
    ..These results indicate that activin A enhances APRIL expression through both activin receptor-like kinase 4 (ALK4) and Smad3...
  25. Herhaus L, Pérez Oliva A, Cozza G, Gourlay R, Weidlich S, Campbell D, et al. Casein kinase 2 (CK2) phosphorylates the deubiquitylase OTUB1 at Ser16 to trigger its nuclear localization. Sci Signal. 2015;8:ra35 pubmed publisher
    ..Our findings indicate that the activity of CK2 is necessary for the nuclear translocation and subsequent function of OTUB1 in DNA damage repair. ..
  26. Lagadec R, Lanoizelet M, Sánchez Farías N, Hérard F, Menuet A, Mayeur H, et al. Neurogenetic asymmetries in the catshark developing habenulae: mechanistic and evolutionary implications. Sci Rep. 2018;8:4616 pubmed publisher
    ..At later stages, marked, Alk4/5/7 dependent, size asymmetries having no clear counterparts in zebrafish also develop in neural progenitor ..
  27. Ohno Y, Shingyoku S, Miyake S, Tanaka A, Fudesaka S, Shimizu Y, et al. Differential regulation of the sphere formation and maintenance of cancer-initiating cells of malignant mesothelioma via CD44 and ALK4 signaling pathways. Oncogene. 2018;37:6357-6367 pubmed publisher
    ..The expression of activin-A was also increased in the spheroids, and type I activin-A receptor subunit (ALK4) was upregulated in the ALDHbright CICs...
  28. Guner Ataman B, González Rosa J, Shah H, Butty V, Jeffrey S, Abrial M, et al. Failed Progenitor Specification Underlies the Cardiopharyngeal Phenotypes in a Zebrafish Model of 22q11.2 Deletion Syndrome. Cell Rep. 2018;24:1342-1354.e5 pubmed publisher
    ..5 and tbx1 are co-expressed in this progenitor population. Furthermore, we present evidence suggesting that gdf3-ALK4 signaling is a downstream mediator of nkx2.5+ pharyngeal lineage specification...
  29. Wójciak M, Gozdowska J, Deborska Materkowska D, Perkowska Ptasinska A, Kosieradzki M, Nazarewski S, et al. Posttransplant Lymphoproliferative Disorder in Kidney and Liver Transplant Recipients: A Single-Center Experience. Transplant Proc. 2018;50:2154-2158 pubmed publisher
    ..b>ALK4- anaplastic lymphoma was diagnosed in 1 (8%) recipient...
  30. Goh B, Singhal V, Herrera A, Tomlinson R, Kim S, Faugere M, et al. Activin receptor type 2A (ACVR2A) functions directly in osteoblasts as a negative regulator of bone mass. J Biol Chem. 2017;292:13809-13822 pubmed publisher
    ..Primary osteoblasts expressed activin signaling components, including ACVR2A, ACVR2B, and ACVR1B (ALK4) and demonstrated increased levels of phosphorylated Smad2/3 upon exposure to activin ligands...
  31. Feger M, Hase P, Zhang B, Hirche F, Glosse P, Lang F, et al. The production of fibroblast growth factor 23 is controlled by TGF-β2. Sci Rep. 2017;7:4982 pubmed publisher
    ..an inhibitor of the transforming growth factor-β (TGF-β) type I receptor activin receptor-like kinases ALK5, ALK4, and ALK7. Furthermore, the TGF-β2 effect on FGF23 production was blunted by SOCE inhibitor 2-APB...
  32. Xu Z, Ichikawa N, Kosaki K, Yamada Y, Sasaki T, Sakai L, et al. Perlecan deficiency causes muscle hypertrophy, a decrease in myostatin expression, and changes in muscle fiber composition. Matrix Biol. 2010;29:461-70 pubmed publisher
    ..Myostatin and its type I receptor (ALK4) expression was substantially decreased in the Hspg2(-/-)-Tg TA muscle...
  33. Vanbekbergen N, Hendrickx M, Leyns L. Growth differentiation factor 11 is an encephalic regionalizing factor in neural differentiated mouse embryonic stem cells. BMC Res Notes. 2014;7:766 pubmed publisher
    ..In addition, inhibition of the TGF-β type I receptors Alk4, Alk5 and Alk7 by the pharmacological inhibitor SB431542 caused a strong anteriorization of the cells...
  34. Loying P, Manhas J, Sen S, Bose B. Autoregulation and heterogeneity in expression of human Cripto-1. PLoS ONE. 2015;10:e0116748 pubmed publisher
    ..Using U-87 MG cells treated with exogenous CR-1, we show that such induction involves ALK4/SMAD2/3 pathway...
  35. Carrarelli P, Funghi L, Ciarmela P, Centini G, Reis F, Dela Cruz C, et al. Deep Infiltrating Endometriosis and Endometrial Adenocarcinoma Express High Levels of Myostatin and Its Receptors Messenger RNAs. Reprod Sci. 2017;24:1577-1582 pubmed publisher
    ..the messenger RNA (mRNA) expression of myostatin and myostatin receptors (activin receptor-like kinase 4 [ALK4], transforming growth factor (TGF)-? type I receptor kinase [ALK5] and activin receptor type IIB [ActRIIB]) in ..
  36. Morrow J, Cho M, Platig J, Zhou X, DeMeo D, Qiu W, et al. Ensemble genomic analysis in human lung tissue identifies novel genes for chronic obstructive pulmonary disease. Hum Genomics. 2018;12:1 pubmed publisher
    ..The genes HNRNPAB and PCBP2 with RNA binding activity and the gene ACVR1B were identified in network communities with validated disease relevance...
  37. Liu C, Yuan B, Chen H, Xu M, Sun X, Xu J, et al. Effects of MiR-375-BMPR2 as a Key Factor Downstream of BMP15/GDF9 on the Smad1/5/8 and Smad2/3 Signaling Pathways. Cell Physiol Biochem. 2018;46:213-225 pubmed publisher
    ..used to detect changes before and after transfection in the expression levels of the BMP15/GDF9 type I receptors ALK4, ALK5 and ALK6; the phosphorylation levels of Smad2/3 and Smad1/5/8, which are key signaling pathway proteins ..
  38. Huang T, Engelmann B, Morgan R, Absher K, Kolesar J, Villano J. EML4-ALK rearrangement in squamous cell carcinoma shows significant response to anti-ALK inhibitor drugs crizotinib and alectinib. Cancer Chemother Pharmacol. 2018;81:965-968 pubmed publisher
    ..We report an EML4-ALK4 translocation in a 50-year-old patient with squamous cell carcinoma and an 18 pack-year smoking history...
  39. Cheewasopit W, Laird M, Glister C, Knight P. Myostatin is expressed in bovine ovarian follicles and modulates granulosal and thecal steroidogenesis. Reproduction. 2018;: pubmed publisher
    ..Here, we first examined relative expression of myostatin (MSTN), myostatin receptors (ACVR1B, ACVR2B and TGFBR1) and binding protein, follistatin (FST), in granulosa (GC) and theca (TC) cells of developing ..
  40. Merfeld Clauss S, Lupov I, Lu H, Feng D, Compton Craig P, March K, et al. Adipose stromal cells differentiate along a smooth muscle lineage pathway upon endothelial cell contact via induction of activin A. Circ Res. 2014;115:800-9 pubmed publisher
    ..In EC-ASC cocultures, activin A IgG or ALK4/5/7 receptor inhibitors blocked expression of α-smooth muscle actin in ASC in the absence of direct EC-cord ..
  41. Nicolas N, Michel V, Bhushan S, Wahle E, Hayward S, Ludlow H, et al. Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice. Sci Rep. 2017;7:42391 pubmed publisher
    ..of the disease, whereas mRNA expression of the inhibin B subunits (Inha and Inhbb) and activin receptor subunits (Acvr1b and Acvr2b) were downregulated...
  42. Finkenzeller G, Stark G, Strassburg S. Growth differentiation factor 11 supports migration and sprouting of endothelial progenitor cells. J Surg Res. 2015;198:50-6 pubmed publisher
    ..pbEPCs express the TGF-β type-I receptors ALK4 and ALK5, but not ALK7...
  43. Chang H, Cheng J, Huang H, Shi F, Leung P. Activin A, B and AB decrease progesterone production by down-regulating StAR in human granulosa cells. Mol Cell Endocrinol. 2015;412:290-301 pubmed publisher
    ..Interestingly, the small interfering RNA-mediated knockdown of ALK4 but not ALK5 reversed the activin-induced suppression of StAR...
  44. Sinnberg T, Niessner H, Levesque M, Dettweiler C, Garbe C, Busch C. Embryonic bone morphogenetic protein and nodal induce invasion in melanocytes and melanoma cells. Biol Open. 2018;7: pubmed publisher
    ..Blocking either BMP or nodal signaling by antagonists (noggin, lefty), or the Alk4/5/7-receptor inhibitor SB431542, decreases EMT and invasion of melanoma cells in human epidermal skin reconstructs...
  45. Xu J, McKeehan K, Matsuzaki K, McKeehan W. Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism. J Biol Chem. 1995;270:6308-13 pubmed
    ..Activin type I receptors, SKR1 and SKR2, were first cloned from well differentiated human hepatoma cells (HepG2)...
  46. Zhao H, Klausen C, Li Y, Zhu H, Wang Y, Leung P. Bone morphogenetic protein 2 promotes human trophoblast cell invasion by upregulating N-cadherin via non-canonical SMAD2/3 signaling. Cell Death Dis. 2018;9:174 pubmed publisher
    ..Interestingly, activation of SMAD2/3 and upregulation of N-cadherin were partially attenuated by ALK4/5/7 inhibitor SB431542 or knockdown of ALK4, but not ALK5...
  47. Tsuchida K, Nakatani M, Yamakawa N, Hashimoto O, Hasegawa Y, Sugino H. Activin isoforms signal through type I receptor serine/threonine kinase ALK7. Mol Cell Endocrinol. 2004;220:59-65 pubmed
    ..is mediated through a combination of activin type II receptors (ActRIIs) and the activin type IB receptor, ALK4. Signaling receptors of other activin isoforms remain to be elucidated...
  48. Song Z, Wu P, Ni J, Liu T, Fan C, Bao Y, et al. Testes-specific protease 50 promotes cell proliferation via inhibiting activin signaling. Oncogene. 2017;36:5948-5957 pubmed publisher
    ..Mechanistic studies revealed that TSP50 could interact with ActRIIA, inhibit activin typeIreceptor (ActRIB) phosphorylation, repress Smad2/3 nuclear accumulation and finally promote cell proliferation by reducing the ..
  49. Sun Z, Ettensohn C. TGF-? sensu stricto signaling regulates skeletal morphogenesis in the sea urchin embryo. Dev Biol. 2017;421:149-160 pubmed publisher
    ..We provide pharmacological evidence that Alk4/5/7 is the cognate TGF-? type I receptor that pairs with TgfbrtII and show by inhibitor treatments of isolated ..
  50. Estienne A, Lahoz B, Jarrier P, Bodin L, Folch J, Alabart J, et al. BMP15 regulates the inhibin/activin system independently of ovulation rate control in sheep. Reproduction. 2017;153:395-404 pubmed publisher
    ..There were only small differences between mutant and wild-type ewes for mRNA expression of INHA, INHBA, ACVR1B, ACVR2A, FST or TGFBR3 in granulosa cells and inhibin A or activin A concentrations in follicular fluid...
  51. Bauer J, Ozden O, Akagi N, Carroll T, Principe D, Staudacher J, et al. Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer. Mol Cancer. 2015;14:182 pubmed publisher
    ..Activin, but not TGFβ, led to PI3K activation via interaction of ACVR1B and p85 independent of SMAD4, resulting in p21 downregulation...
  52. Galvão A, Wolodko K, Rebordão M, Skarzynski D, Ferreira Dias G. TGFB1 modulates in vitro secretory activity and viability of equine luteal cells. Cytokine. 2018;110:316-327 pubmed publisher
    ..05). Additionally, treatment with the pharmacological inhibitor of ALK5, ALK4 and ALK7 - SB431542 (SB) attenuated PGF2a functional and structural luteolytic actions...
  53. Li C, Zhang H, Liang Y, Xia W, Zhu Q, Zhang D, et al. Effects of Levonorgestrel and progesterone on Oviductal physiology in mammals. Reprod Biol Endocrinol. 2018;16:59 pubmed publisher
    ..the levels of fallopian tubal epithelial cell receptive markers, including LIF, STAT3, IGFBP1, ITGB3, MUC1, and ACVR1B, or affect JAr-spheroid implantation...
  54. Calvanese L, Sandomenico A, Caporale A, Focà A, Focà G, D Auria G, et al. Conformational features and binding affinities to Cripto, ALK7 and ALK4 of Nodal synthetic fragments. J Pept Sci. 2015;21:283-93 pubmed publisher
    ..Recently, we reported the molecular models of Nodal in complex with its type I receptors (ALK4 and ALK7) as well as with Cripto, as obtained by homology modeling and docking simulations...
  55. Olsen O, Sankar M, Elsaadi S, Hella H, Buene G, Darvekar S, et al. BMPR2 inhibits activin and BMP signaling via wild-type ALK2. J Cell Sci. 2018;131: pubmed publisher
    ..Activin A activates the transcription factors SMAD2/3 through the ALK4 type 1 receptor, but may also activate SMAD1/5/8 through mutated variants of the type 1 receptor ALK2 (also known ..
  56. Lebrun J, Vale W. Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation. Mol Cell Biol. 1997;17:1682-91 pubmed
    ..Finally, using cell lines that can be induced to overexpress ActRII and ActRIB or ActRIB only, we show that the inhibin antagonistic effects on activin-induced biological responses are mediated ..
  57. Ungefroren H, Hyder A, Hinz H, Groth S, Lange H, El Sayed K, et al. Pluripotency gene expression and growth control in cultures of peripheral blood monocytes during their conversion into programmable cells of monocytic origin (PCMO): evidence for a regulatory role of autocrine activin and TGF-β. PLoS ONE. 2015;10:e0118097 pubmed publisher
    ..Realtime-PCR analysis showed that PCMO express ActRIIA, ALK4, TβRII, ALK5 as well as TGF-β1 and the βA subunit of activin...
  58. Hu J, Wang X, Wei S, Tang Y, Zhou Q, Huang C. Activin A stimulates the proliferation and differentiation of cardiac fibroblasts via the ERK1/2 and p38-MAPK pathways. Eur J Pharmacol. 2016;789:319-327 pubmed publisher
    ..differentiation of adult rat cardiac fibroblasts (CFs) via the activin A receptor, activin receptor-like kinase 4 (ALK4)...
  59. Foley S, Van Vlijmen H, Boynton R, Adkins H, Cheung A, Singh J, et al. The CRIPTO/FRL-1/CRYPTIC (CFC) domain of human Cripto. Functional and structural insights through disulfide structure analysis. Eur J Biochem. 2003;270:3610-8 pubmed
    ..Biochemical studies of the interactions of ALK4 with the CFC domain of Cripto by fluorescence-activated cell sorter analysis indicate that the CFC domain binds to ..
  60. Ellis P, Burbridge S, Soubes S, Ohyama K, Ben Haim N, Chen C, et al. ProNodal acts via FGFR3 to govern duration of Shh expression in the prechordal mesoderm. Development. 2015;142:3821-32 pubmed publisher
    ..Exposure of prechordal mesoderm microcultures to Nodal-conditioned medium, the Nodal inhibitor CerS, or to an ALK4/5/7 inhibitor reveals that Nodal is required to maintain both Shh and Gsc expression, but whereas Gsc is largely ..
  61. Chen Y, Chang H, Cheng J, Tsai H, Wu C, Leung P. Transforming growth factor-β1 up-regulates connexin43 expression in human granulosa cells. Hum Reprod. 2015;30:2190-201 pubmed publisher
    ..An activin/TGF-β type I receptor inhibitor, SB431542, and small interfering RNAs targeting ALK4, ALK5, SMAD2, SMAD3 and SMAD4 were used to verify the specificity of the effects and to investigate the molecular ..
  62. Mukasa C, Nomura M, Tanaka T, Tanaka K, Nishi Y, Okabe T, et al. Activin signaling through type IB activin receptor stimulates aromatase activity in the ovarian granulosa cell-like human granulosa (KGN) cells. Endocrinology. 2003;144:1603-11 pubmed
    ..A series of transient transfection experiments revealed that activin type IB receptor (ActRIB) is an essential component of the activin signaling pathway in KGN cells...
  63. Qi Y, Wu L, Li Z, Wu M, Wang H, Chan K, et al. Nodal signaling modulates the expression of Oct-4 via nuclear translocation of β-catenin in lung and prostate cancer cells. Arch Biochem Biophys. 2016;608:34-41 pubmed publisher
    ..This increase was attributed to GSK-3β dephosphorylating, and activin receptor-like kinase 4/7 (ALK4/7) played a major role in human cancer cells...
  64. Zheng J, Qu J, Lu P, Hou Z, Cui Y, Mao Y, et al. Activin A Stimulates Aromatase via the ALK4-Smad Pathway in Endometriosis. Biomed Res Int. 2016;2016:5791510 pubmed
    ..of Activin A on ESCs was partially abrogated by pretreatment with an inhibitor of ALK4 (the type I receptor, ActRIB) and Smad4-siRNA...
  65. Voisin S, Guilherme J, Yan X, Pushkarev V, Cieszczyk P, Massidda M, et al. ACVR1B rs2854464 Is Associated with Sprint/Power Athletic Status in a Large Cohort of Europeans but Not Brazilians. PLoS ONE. 2016;11:e0156316 pubmed publisher
    ..However, to date, only a handful of genetic variants have been associated with sprint/power performance. The ACVR1B A allele (rs rs2854464) has previously been associated with increased muscle-strength in non-athletic cohort...
  66. Kanamori Y, Sugiyama M, Hashimoto O, Murakami M, Matsui T, Funaba M. Regulation of hepcidin expression by inflammation-induced activin B. Sci Rep. 2016;6:38702 pubmed publisher
    ..and increased expression of connective tissue growth factor, a gene related to liver fibrogenesis, through ALK4 and ActRIIA/B. Activin B-induced activation of the BR-Smad pathway was also detected in non-liver-derived cells...
  67. DEAN M, Davis D, Burdette J. Activin A stimulates migration of the fallopian tube epithelium, an origin of high-grade serous ovarian cancer, through non-canonical signaling. Cancer Lett. 2017;391:114-124 pubmed publisher
    ..In Oncomine, transcripts for the activin A receptors (ACVR1B and ACVR2A) were higher in serous tumors relative to the normal ovary, while inhibitors of activin A signaling (..
  68. Song C, Fan B, Xiao Z. Overexpression of ALK4 inhibits cell proliferation and migration through the inactivation of JAK/STAT3 signaling pathway in glioma. Biomed Pharmacother. 2018;98:440-445 pubmed publisher
    Aristaless-like homeobox 4 (ALK4) is a member of ALK proteins family and plays an important role in tumorigenesis. However, the expression and function of ALK4 in glioma remain largely unknown...
  69. Nomura M, Tanaka K, Wang L, Goto Y, Mukasa C, Ashida K, et al. Activin type IB receptor signaling in prostate cancer cells promotes lymph node metastasis in a xenograft model. Biochem Biophys Res Commun. 2013;430:340-6 pubmed publisher
  70. Olsen O, Wader K, Hella H, Mylin A, Turesson I, Nesthus I, et al. Activin A inhibits BMP-signaling by binding ACVR2A and ACVR2B. Cell Commun Signal. 2015;13:27 pubmed publisher
    ..Signaling by activin A through canonical ALK4-ACVR2 receptor complexes activates the transcription factors SMAD2 and SMAD3...
  71. Hosseini S, Hajian M, Ostadhosseini S, Forouzanfar M, Abedi P, Jafarpour F, et al. Contrasting effects of G1.2/G2.2 and SOF1/SOF2 embryo culture media on pre- and post-implantation development of non-transgenic and transgenic cloned goat embryos. Reprod Biomed Online. 2015;31:372-83 pubmed publisher
    ..developmentally important genes revealed that: (i) SOX2, FOXD3, IFNT, FZD, FGFR4, ERK1, GCN5, PCAF, BMPR1, SMAD5, ALK4, CDC25 and LIFR were significantly induced in blastocysts developed in SOF1/SOF2 but not G1.2/G2...
  72. Focà A, Sanguigno L, Focà G, Strizzi L, Iannitti R, Palumbo R, et al. New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding. Int J Mol Sci. 2015;16:21342-62 pubmed publisher
    Nodal is a potent embryonic morphogen belonging to the TGF-β superfamily. Typically, it also binds to the ALK4/ActRIIB receptor complex in the presence of the co-receptor Cripto-1...
  73. Chen H, Liu C, Jiang H, Gao Y, Xu M, Wang J, et al. Regulatory Role of miRNA-375 in Expression of BMP15/GDF9 Receptors and its Effect on Proliferation and Apoptosis of Bovine Cumulus Cells. Cell Physiol Biochem. 2017;41:439-450 pubmed publisher
    ..The BMP15/GDF9 heterodimer needs to bind to the BMPR2-ALK4/5/7-ALK6 receptor complex to activate the SMAD2/3 signaling pathway...
  74. Takagi K, Kawaguchi Y, Kawamoto M, Ota Y, Tochimoto A, Gono T, et al. Activation of the activin A-ALK-Smad pathway in systemic sclerosis. J Autoimmun. 2011;36:181-8 pubmed publisher
    ..A levels in patients with SSc were measured by ELISA, and the expression of the activin receptor type IB (ACVRIB/ALK4) and the activity of the signaling pathway via ACVRIB/ALK4 were investigated using western blotting...
  75. Kottgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, et al. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nat Genet. 2013;45:145-54 pubmed publisher
    ..TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4)...
  76. Bollum L, Huse K, Oksvold M, Bai B, Hilden V, Forfang L, et al. BMP-7 induces apoptosis in human germinal center B cells and is influenced by TGF-β receptor type I ALK5. PLoS ONE. 2017;12:e0177188 pubmed publisher
    ..BMP-7-induced apoptosis was counteracted by a selective TGF-β type I receptor (ALK4/5/7) inhibitor, but not by a selective BMP receptor type I inhibitor...
  77. Schneider Kolsky M, Manuelpillai U, Waldron K, Dole A, Wallace E. The distribution of activin and activin receptors in gestational tissues across human pregnancy and during labour. Placenta. 2002;23:294-302 pubmed
    ..There were no differences with labour onset. ..
  78. Sun Z, Schriewer J, Tang M, Marlin J, Taylor F, Shohet R, et al. The TGF-β pathway mediates doxorubicin effects on cardiac endothelial cells. J Mol Cell Cardiol. 2016;90:129-38 pubmed publisher
    Elevated ALK4/5 ligands including TGF-β and activins have been linked to cardiovascular remodeling and heart failure...
  79. Walker R, Czepnik M, Goebel E, McCoy J, Vujic A, Cho M, et al. Structural basis for potency differences between GDF8 and GDF11. BMC Biol. 2017;15:19 pubmed publisher
    ..potent activator of SMAD2/3 and signals more effectively through the type I activin-like receptor kinase receptors ALK4/5/7 than GDF8...
  80. van Caam A, Madej W, García de Vinuesa A, Goumans M, Ten Dijke P, Blaney Davidson E, et al. TGF?1-induced SMAD2/3 and SMAD1/5 phosphorylation are both ALK5-kinase-dependent in primary chondrocytes and mediated by TAK1 kinase activity. Arthritis Res Ther. 2017;19:112 pubmed publisher
    ..To modulate TGF? signaling the activin receptor-like kinase (ALK)1/2/3/6 inhibitor LDN-193189, the ALK4/5/7 inhibitor SB-505124 and the TAK1 inhibitor (5Z)-7-Oxozeaenol were used...
  81. Galvão A, Skarzynski D, Ferreira Dias G. Nodal Promotes Functional Luteolysis via Down-Regulation of Progesterone and Prostaglandins E2 and Promotion of PGF2α Synthetic Pathways in Mare Corpus Luteum. Endocrinology. 2016;157:858-71 pubmed publisher
    ..pattern of Nodal and its receptors activin receptor A type IIB (ACVR2B), activin receptor-like kinase (Alk)-7, and Alk4, as well as the Nodal physiological role, demonstrate the involvement of this pathway in functional luteolysis...
  82. Kunnen S, Leonhard W, Semeins C, Hawinkels L, Poelma C, Ten Dijke P, et al. Fluid shear stress-induced TGF-?/ALK5 signaling in renal epithelial cells is modulated by MEK1/2. Cell Mol Life Sci. 2017;74:2283-2298 pubmed publisher
    ..This response was still present after cilia ablation. An inhibitor of upstream type-I-receptors, ALK4/ALK5/ALK7, as well as TGF-?-neutralizing antibodies effectively blocked SMAD2/3 activity...
  83. Wurthner J, Frank D, Felici A, Green H, Cao Z, Schneider M, et al. Transforming growth factor-beta receptor-associated protein 1 is a Smad4 chaperone. J Biol Chem. 2001;276:19495-502 pubmed
  84. Yamaguchi T, Kurisaki A, Yamakawa N, Minakuchi K, Sugino H. FKBP12 functions as an adaptor of the Smad7-Smurf1 complex on activin type I receptor. J Mol Endocrinol. 2006;36:569-79 pubmed
    ..a member of TGF-beta superfamily, also induced the dissociation of FKBP12 from the activin type I receptor (ALK4). However, we observed that the released FKBP12 associates again with the receptor a few hours later...
  85. Windelinckx A, De Mars G, Huygens W, Peeters M, Vincent B, Wijmenga C, et al. Comprehensive fine mapping of chr12q12-14 and follow-up replication identify activin receptor 1B (ACVR1B) as a muscle strength gene. Eur J Hum Genet. 2011;19:208-15 pubmed publisher
    ..Combined linkage and family-based association analyses identified activin receptor 1B (ACVR1B) and inhibin ? C (INHBC), part of the transforming growth factor ? pathway regulating myostatin - a negative ..
  86. Chen M, Lin H, Shen C, Ma Y, Wang F, Zhao H, et al. PU.1-Regulated Long Noncoding RNA lnc-MC Controls Human Monocyte/Macrophage Differentiation through Interaction with MicroRNA 199a-5p. Mol Cell Biol. 2015;35:3212-24 pubmed publisher
    ..sequester microRNA 199a-5p (miR-199a-5p) and alleviate repression on the expression of activin A receptor type 1B (ACVR1B), an important regulator of monocyte/macrophage differentiation...
  87. Souchelnytskyi S, Nakayama T, Nakao A, Moren A, Heldin C, Christian J, et al. Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-beta receptors. J Biol Chem. 1998;273:25364-70 pubmed
    ..Our results are consistent with the possibility that the C-domain of antagonistic Smads is an effector domain whereas the N-domain may confer specificity for distinct signaling pathways. ..
  88. Harrison C, Gray P, Koerber S, Fischer W, Vale W. Identification of a functional binding site for activin on the type I receptor ALK4. J Biol Chem. 2003;278:21129-35 pubmed
    ..two types of transmembrane serine/threonine receptor kinases classified as type II (ActRII or ActRIIB) and type I (ALK4)...
  89. Zhang L, Zhou H, Su Y, Sun Z, Zhang H, Zhang L, et al. Zebrafish Dpr2 inhibits mesoderm induction by promoting degradation of nodal receptors. Science. 2004;306:114-7 pubmed
    ..Dpr2 is localized in late endosomes, binds to the TGFbeta receptors ALK5 and ALK4, and accelerates lysosomal degradation of these receptors.
  90. Esguerra C, Nelles L, Vermeire L, Ibrahimi A, Crawford A, Derua R, et al. Ttrap is an essential modulator of Smad3-dependent Nodal signaling during zebrafish gastrulation and left-right axis determination. Development. 2007;134:4381-93 pubmed
    ..Stimulation of Alk4/EGF-CFC receptor complexes by Nodal activates Smad2/3, leading to left-sided expression of target genes that ..
  91. Siragam V, Rutnam Z, Yang W, Fang L, Luo L, Yang X, et al. MicroRNA miR-98 inhibits tumor angiogenesis and invasion by targeting activin receptor-like kinase-4 and matrix metalloproteinase-11. Oncotarget. 2012;3:1370-85 pubmed
    ..Interestingly, miR-98 reduced the expression of ALK4 and MMP11, both of which were potential targets of miR-98...
  92. Xu J, Matsuzaki K, McKeehan K, Wang F, Kan M, McKeehan W. Genomic structure and cloned cDNAs predict that four variants in the kinase domain of serine/threonine kinase receptors arise by alternative splicing and poly(A) addition. Proc Natl Acad Sci U S A. 1994;91:7957-61 pubmed