ACTR1B

Summary

Gene Symbol: ACTR1B
Description: ARP1 actin related protein 1 homolog B
Alias: ARP1B, CTRN2, PC3, beta-centractin, ARP1 actin-related protein 1 homolog B, centractin beta, actin-related protein 1B, centractin beta
Species: human
Products:     ACTR1B

Top Publications

  1. Chaves Neto A, Pelizzaro Rocha K, Fernandes M, Ferreira Halder C. Antitumor activity of irradiated riboflavin on human renal carcinoma cell line 786-O. Tumour Biol. 2015;36:595-604 pubmed publisher
    ..riboflavin (IR) has potential antitumoral effects against human leukemia cells (HL60), human prostate cancer cells (PC3), and mouse melanoma cells (B16F10) through a common mechanism that leads to apoptosis...
  2. Chen Z, Yu Y, Tao J, Liu S, Tseng G, Nalesnik M, et al. MAN2A1-FER Fusion Gene Is Expressed by Human Liver and Other Tumor Types and Has Oncogenic Activity in Mice. Gastroenterology. 2017;153:1120-1132.e15 pubmed publisher
    ..MAN2A1-FER was also overexpressed in PC3 or DU145 (prostate cancer), NIH3T3 (fibroblast), H23 (lung cancer), and A-172 (glioblastoma multiforme) cell lines ..
  3. Edderkaoui M, Chheda C, Soufi B, Zayou F, Hu R, Ramanujan V, et al. An Inhibitor of GSK3B and HDACs Kills Pancreatic Cancer Cells and Slows Pancreatic Tumor Growth and Metastasis in Mice. Gastroenterology. 2018;155:1985-1998.e5 pubmed publisher
    ..We tested the ability of Metavert to bind GSK3B and HDACs using surface plasmon resonance. MIA PaCa-2, Bx-PC3, HPAF-II, and HPDE6 cell lines were incubated with different concentrations of Metavert, with or without ..
  4. Tong Q, Zhu Y, Galaske J, Kosmacek E, Chatterjee A, Dickinson B, et al. MnTE-2-PyP modulates thiol oxidation in a hydrogen peroxide-mediated manner in a human prostate cancer cell. Free Radic Biol Med. 2016;101:32-43 pubmed publisher
    ..is likely the mediator through which MnTE-2-PyP inhibits the PAI-1 expression and p300 complex binding in PC3 cells...
  5. Heeba G, Hamza A, Hassanin S. Induction of heme oxygenase-1 with hemin alleviates cisplatin-induced reproductive toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line. Toxicol Lett. 2016;264:38-50 pubmed publisher
    ..anticancer effect of hemin and ZnPP, with and without cisplatin, was evaluated on human prostate cancer cell line, PC3. Results of the animal study showed that hemin reversed cisplatin-induced perturbations in sperm characteristics, ..
  6. Wang Z, Hsu H, Chou J, Yu C, Bau D, Wang G, et al. Cytotoxic effect of s-petasin and iso-s-petasin on the proliferation of human prostate cancer cells. Anticancer Res. 2015;35:191-9 pubmed
    ..the effects of S-petasin and iso-S-petasin on the growth and proliferation of two hormone-independent DU145 and PC3 and one hormone-dependent LNCaP prostate cancer cell line at concentrations of 10(-7)-10(-5) mol/l...
  7. Hirsch G, Parisi M, Martins L, Andrade C, Barbé Tuana F, Guma F. γ-Oryzanol reduces caveolin-1 and PCGEM1 expression, markers of aggressiveness in prostate cancer cell lines. Prostate. 2015;75:783-97 pubmed publisher
    ..decreases cell viability and culture biomass by apoptosis and/or necrosis death in androgen unresponsive (PC3 and DU145) and responsive (LNCaP) cell lines, and signals through pERK1/2 in LNCaP and DU145 cells...
  8. Salama W, Ibrahim N, El Hakim A, Bassuiny R, Mohamed M, Mousa F, et al. l-Amino acid oxidase from Cerastes vipera snake venom: Isolation, characterization and biological effects on bacteria and tumor cell lines. Toxicon. 2018;150:270-279 pubmed publisher
    ..75 ± 0.38 μg/ml compared with different tumor cell lines (liver HepG2, lung A549, colon HCT116 and prostate PC3)...
  9. Gravina G, Mancini A, Muzi P, Ventura L, Biordi L, Ricevuto E, et al. CXCR4 pharmacogical inhibition reduces bone and soft tissue metastatic burden by affecting tumor growth and tumorigenic potential in prostate cancer preclinical models. Prostate. 2015;75:1227-46 pubmed publisher
    ..The reduced intra-osseous growth of PC3 and PCb2 tumor cells after intratibial injection, as a result of Plerixafor and CTE9908 treatment, correlated with ..

More Information

Publications157 found, 100 shown here

  1. Peleg R, Romzova M, Kogan Zviagin I, Apte R, Priel E. Modification of topoisomerases in mammospheres derived from breast cancer cell line: clinical implications for combined treatments with tyrosine kinase inhibitors. BMC Cancer. 2014;14:910 pubmed publisher
    ..MCF7 breast cancer cells, PC3 prostate cancer cells and 4 T1-Luc-Oct3/4pG mouse mammary carcinoma cells were grown on low-attachment dishes in ..
  2. Gu B, Li L, Li M, Wang J, Zhang G, Yao K, et al. U94/rep of human herpesvirus 6 inhibits proliferation, invasion, and angiogenesis of glioma. Cancer Manag Res. 2018;10:5991-6001 pubmed publisher
    ..have shown its inhibition of angiogenesis and tumorigenesis in endothelial cells and prostate cancer cell line PC3, respectively. Here, we aimed to investigate the role of U94/rep in the development and progression of glioma...
  3. García Tobilla P, Solórzano S, Salido Guadarrama I, Gonzalez Covarrubias V, Morales Montor G, Díaz Otañez C, et al. SFRP1 repression in prostate cancer is triggered by two different epigenetic mechanisms. Gene. 2016;593:292-301 pubmed publisher
    ..Interestingly, we observed DNA hypermethylation at the promoter of SFRP1 in the PC3 cell line, but not in LNCaP...
  4. Qian X, Feng S, Xie D, Feng D, Jiang Y, Zhang X. RecQ helicase BLM regulates prostate cancer cell proliferation and apoptosis. Oncol Lett. 2017;14:4206-4212 pubmed publisher
    ..The expression of BLM was significantly increased in PCa tissues and PC3 cells compared with non-PCa tissues and benign prostatic hyperplasia cells...
  5. Mukherjee A, Ghosh S, Sarkar R, Samanta S, Ghosh S, Pal M, et al. Synthesis, characterization and unravelling the molecular interaction of new bioactive 4-hydroxycoumarin derivative with biopolymer: Insights from spectroscopic and theoretical aspect. J Photochem Photobiol B. 2018;189:124-137 pubmed publisher
    ..help of MTT assay by normal kidney epithelial (NKE), breast cancer cells (MCF-7) and human prostate cancer cell (PC3) lines...
  6. Liu Y, Xu X, Xu X, Li S, Liang Z, Hu Z, et al. MicroRNA-193a-3p inhibits cell proliferation in prostate cancer by targeting cyclin D1. Oncol Lett. 2017;14:5121-5128 pubmed publisher
    ..Forced overexpression of miR-193a-3p was established by transfecting mimics into DU-145 and PC3 cell lines...
  7. Cheng G, Wang S, Li X, Li S, Zheng Y, Zhang L, et al. Positive expression of NR6A1/CT150 as a predictor of biochemical recurrence-free survival in prostate cancer patients. Oncotarget. 2017;8:64427-64439 pubmed publisher
    ..G0/G1 phase cell cycle arrest, and decreased metastatic and invasive potential of prostate cancer cells DU145 and PC3. In contrast, overexpression of NR6A1 reduced G0/G1 phase cell cycle arrest, and promoted metastatic and invasive ..
  8. Reyes Corral M, Sørensen N, Thrasivoulou C, Dasgupta P, Ashmore J, Ahmed A. Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines. J Pharmacol Exp Ther. 2019;369:152-162 pubmed publisher
    ..and sotalol), on Ca2+ i release and whole-cell currents in mammalian cancer cells (PC3 prostate cancer and MCF7 breast cancer cell lines)...
  9. Osorio L, Farfán N, Castellón E, Contreras H. SNAIL transcription factor increases the motility and invasive capacity of prostate cancer cells. Mol Med Rep. 2016;13:778-86 pubmed publisher
    ..The present study was performed using LNCaP and PC3 cell lines, in which the expression levels of SNAIL1 were increased or silenced through the use of lentiviral ..
  10. Zater H, Huet J, Fontaine V, Benayache S, Stévigny C, Duez P, et al. Chemical constituents, cytotoxic, antifungal and antimicrobial properties of Centaurea diluta Ait. subsp. algeriensis (Coss. & Dur.) Maire. Asian Pac J Trop Med. 2016;9:554-61 pubmed publisher
    ..literature, were evaluated for cytotoxic activities on six cancer cell lines (A549, MCF7, U373, Hs683 human glioma, PC3 human prostate and B16-F10 murine melanoma)...
  11. Mansour H, Eid M, El Arnaouty M. Effect of silver nanoparticles synthesized by gamma radiation on the cytotoxicity of doxorubicin in human cancer cell lines and experimental animals. Hum Exp Toxicol. 2018;37:38-50 pubmed publisher
    ..the DOX-treated group and enhanced the cytotoxicity of DOX in different human cancer cell lines (HepG2, T47D, and PC3)...
  12. Mohamed T, Batran R, Elseginy S, Ali M, Mahmoud A. Synthesis, anticancer effect and molecular modeling of new thiazolylpyrazolyl coumarin derivatives targeting VEGFR-2 kinase and inducing cell cycle arrest and apoptosis. Bioorg Chem. 2019;85:253-273 pubmed publisher
    ..anticancer potential in vitro against five different human cell lines, including breast MCF-7, lung A549, prostate PC3, liver HepG2 and normal melanocyte HFB4...
  13. Ling Z, Wang X, Tao T, Zhang L, Guan H, You Z, et al. Involvement of aberrantly activated HOTAIR/EZH2/miR-193a feedback loop in progression of prostate cancer. J Exp Clin Cancer Res. 2017;36:159 pubmed publisher
    ..EZH2 coupled with HOTAIR to repress miR-193a expression through trimethylation of H3K27 at miR-193a promoter in PC3 and DU145 cells...
  14. Zhang S, Li Z, Zhang L, Xu Z. MEF2‑activated long non‑coding RNA PCGEM1 promotes cell proliferation in hormone‑refractory prostate cancer through downregulation of miR‑148a. Mol Med Rep. 2018;18:202-208 pubmed publisher
    ..In addition, the underlying mechanism of PCGEM1 regulating expression of microRNA (miR)‑148a in PC3 prostate cancer cells was evaluated...
  15. Zhang S, Li L, Qiao H, Yang X, Chen L, Luo X. Regulation of the Antioxidant Response by MyoD Transcriptional Coactivator in Castration-resistant Prostate Cancer Cells. Urology. 2019;123:296.e9-296.e18 pubmed publisher
    ..The effect of MyoD knockdown on the oxidative stress state in PC3 cells was determined by assessing antioxidant response gene expression and glutathione synthetase-to-glutathione ..
  16. Gong P, Zhang T, He D, Hsieh J. MicroRNA-145 Modulates Tumor Sensitivity to Radiation in Prostate Cancer. Radiat Res. 2015;184:630-8 pubmed publisher
    ..Human prostate cancer cells LNCAP and PC3 were transfected with miR-145 mimic...
  17. Chaudhary P, Vishwanatha J. c-Jun NH2-terminal kinase-induced proteasomal degradation of c-FLIPL/S and Bcl2 sensitize prostate cancer cells to Fas- and mitochondria-mediated apoptosis by tetrandrine. Biochem Pharmacol. 2014;91:457-73 pubmed publisher
    ..Here we demonstrated that tetrandrine selectively inhibits the growth of prostate cancer PC3 and DU145 cells compared to normal prostate epithelial PWR-1E cells...
  18. Morelli M, Amantini C, Nabissi M, Liberati S, Cardinali C, Farfariello V, et al. Cross-talk between alpha1D-adrenoceptors and transient receptor potential vanilloid type 1 triggers prostate cancer cell proliferation. BMC Cancer. 2014;14:921 pubmed publisher
    ..of alpha1D-AR and TRPV1 was examined in human PCa tissues by quantitative RT-PCR and in PCa cell lines (DU145, PC3 and LNCaP) by cytofluorimetry...
  19. Park N, Baek H, Chun Y. Embelin-Induced Apoptosis of Human Prostate Cancer Cells Is Mediated through Modulation of Akt and β-Catenin Signaling. PLoS ONE. 2015;10:e0134760 pubmed publisher
    ..Embelin strongly inhibited cell growth especially in human prostate cancer cell lines, including PC3, DU145, LNCaP-LN3 and normal prostate epithelial cell, RWPE-1 compared to breast cancer (MDA-MB-231, MCF-7, and ..
  20. Moiola C, De Luca P, Cotignola J, Gardner K, Vazquez E, De Siervi A. Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription. Cell Physiol Biochem. 2012;30:596-608 pubmed publisher
    ..Here we investigate ATM transcription regulation in human prostate tumor PC3 cell line...
  21. Eke I, Makinde A, Aryankalayil M, Reedy J, Citrin D, Chopra S, et al. Long-term Tumor Adaptation after Radiotherapy: Therapeutic Implications for Targeting Integrins in Prostate Cancer. Mol Cancer Res. 2018;16:1855-1864 pubmed publisher
    ..To analyze the short- and long-term effects of radiation on the integrin expression, prostate cancer cells (DU145, PC3, and LNCaP) were cultured in a 3D extracellular matrix and irradiated with either a single dose of radiation (2-10 ..
  22. Bonesi M, Brindisi M, Armentano B, Curcio R, Sicari V, Loizzo M, et al. Exploring the anti-proliferative, pro-apoptotic, and antioxidant properties of Santolina corsica Jord. & Fourr. (Asteraceae). Biomed Pharmacother. 2018;107:967-978 pubmed publisher
    ..7 cells. Anti-proliferative activity was evaluated by MTT assay on A549, HeLa, PC3, MCF-7, MDA-MB-231 cancer cells, and non-tumorigenic MCF10 A cells...
  23. Kang S, Kim J, Li Y, Jung S, Song N, Thimmegowda N, et al. Hirsutenone in Alnus extract inhibits akt activity and suppresses prostate cancer cell proliferation. Mol Carcinog. 2015;54:1354-62 pubmed publisher
    ..Hirsutenone suppressed anchorage-dependent and independent cell growth of PC3 and LNCaP human prostate cancer cells...
  24. Pistore C, Giannoni E, Colangelo T, Rizzo F, Magnani E, Muccillo L, et al. DNA methylation variations are required for epithelial-to-mesenchymal transition induced by cancer-associated fibroblasts in prostate cancer cells. Oncogene. 2017;36:5551-5566 pubmed publisher
    ..patients with advanced PCa, stimulates concurrent DNA hypo- and hyper-methylation required for EMT and stemness in PC3 and DU145, but not in LN-CaP and its derivative C4-2B, PCa cells...
  25. Yu S, Wang M, Ding X, Xia L, Chen B, Chen Y, et al. Testicular orphan nuclear receptor 4 is associated with the radio-sensitivity of prostate cancer. Prostate. 2015;75:1632-42 pubmed publisher
    ..101, P = 0.001). Using cell survival test and colony forming assay, we found that the addition of functional TR4 in PC3 cells lead to elevated radio-resistance...
  26. Sharma V, Verma V, Lal N, Yadav S, Sarkar S, Mandalapu D, et al. Disulfiram and its novel derivative sensitize prostate cancer cells to the growth regulatory mechanisms of the cell by re-expressing the epigenetically repressed tumor suppressor-estrogen receptor β. Mol Carcinog. 2016;55:1843-1857 pubmed publisher
    ..It potently and selectively inhibited cell proliferation of prostate cancer (PC3/DU145) cells in comparison to normal (non-cancer) cells by promoting cell-cycle arrest and apoptosis, accompanied ..
  27. Zeng J, Liu W, Fan Y, He D, Li L. PrLZ increases prostate cancer docetaxel resistance by inhibiting LKB1/AMPK-mediated autophagy. Theranostics. 2018;8:109-123 pubmed publisher
    ..b>Methods: Human PCa PC3, LNCaP and C4-2 cell lines were used as the model system in vitro and PCa xenografts and PrLZ-knockout mice ..
  28. Lima A, Araújo A, Pinto J, Jerónimo C, Henrique R, Bastos M, et al. GC-MS-Based Endometabolome Analysis Differentiates Prostate Cancer from Normal Prostate Cells. Metabolites. 2018;8: pubmed publisher
    ..The cell lines include 22RV1 and LNCaP from PCa with androgen receptor (AR) expression, DU145 and PC3 (which lack AR expression), and one normal prostate cell line (PNT2)...
  29. Liu Y, Si M, Lu W, Zhang L, Zhou C, Deng S, et al. Effects and molecular mechanisms of the antidiabetic fraction of Acorus calamus L. on GLP-1 expression and secretion in vivo and in vitro. J Ethnopharmacol. 2015;166:168-75 pubmed publisher
    ..The expression of proglucagon gene (gcg) and post-translational processing gene prohormone convertase 3 (pc3) and the GLP-1 content in the culture medium of L-cells notably increased after the ACE treatment (12.5μg/ml)...
  30. Jadhav V, Ray P, Sachdeva G, Bhatt P. Biocompatible arsenic trioxide nanoparticles induce cell cycle arrest by p21(WAF1/CIP1) expression via epigenetic remodeling in LNCaP and PC3 cell lines. Life Sci. 2016;148:41-52 pubmed publisher
    ..Thus, biocompatible As2O3 nanoparticles with reduced toxicity to normal cells but the antiproliferative effect on prostate cancer cell lines follow similar death pathway as that of bare As2O3 nanoparticles. ..
  31. Varol N, Konac E, Bilen C. Does Wnt/β-catenin pathway contribute to the stability of DNMT1 expression in urological cancer cell lines?. Exp Biol Med (Maywood). 2015;240:624-30 pubmed publisher
    ..pathway might have accounted for the stability of DNMT1 expression, whereas such relation is not valid for T24 and PC3 cells...
  32. Gupta S, Weston A, Bearrs J, Thode T, Neiss A, Soldi R, et al. Reversible lysine-specific demethylase 1 antagonist HCI-2509 inhibits growth and decreases c-MYC in castration- and docetaxel-resistant prostate cancer cells. Prostate Cancer Prostatic Dis. 2016;19:349-357 pubmed publisher
    ..b>PC3 xenografts in mice have a significant reduction in tumor burden upon treatment with HCI-2509 with no associated ..
  33. Hu Q, Tong S, Zhao X, Ding W, Gou Y, Xu K, et al. Periostin Mediates TGF-β-Induced Epithelial Mesenchymal Transition in Prostate Cancer Cells. Cell Physiol Biochem. 2015;36:799-809 pubmed publisher
    ..We constructed a lentivirus vector containing the periostin gene and transduced it into PC3 and DU145 cells...
  34. Chatterjee P, Choudhary G, Alswillah T, Xiong X, Heston W, Magi Galluzzi C, et al. The TMPRSS2-ERG Gene Fusion Blocks XRCC4-Mediated Nonhomologous End-Joining Repair and Radiosensitizes Prostate Cancer Cells to PARP Inhibition. Mol Cancer Ther. 2015;14:1896-906 pubmed publisher
    ..VCaP cells, which harbor TMPRSS2-ERG and PC3 cells that stably express it, displayed γH2AX and 53BP1 foci constitutively, indicating persistent DNA damage ..
  35. Hudson B, Hum N, Thomas C, Kohlgruber A, Sebastian A, Collette N, et al. SOST Inhibits Prostate Cancer Invasion. PLoS ONE. 2015;10:e0142058 pubmed publisher
    ..Furthermore, rhDKK1 was found to activate canonical Wnt signaling in PC3 cells, suggesting that SOST and DKK1 have opposing roles on Wnt signaling in this context...
  36. Bano S, Wahab A, Yousuf S, Jabeen A, Mesaik M, Rahman A, et al. New Anti-Inflammatory Metabolites by Microbial Transformation of Medrysone. PLoS ONE. 2016;11:e0153951 pubmed publisher
    ..All these compounds were found to be non-toxic to 3T3 cells (mouse fibroblast), and also showed no activity when tested against HeLa (human epithelial carcinoma), or against PC3 (prostate cancer) cancer cell lines.
  37. Chen Y, Allen D, Tizzard G, Pitak M, Coles S, Cross N, et al. Biological and structural studies of phosphonium 'masked thiolate' compounds. Eur J Med Chem. 2017;125:528-537 pubmed publisher
    ..from triphenylphosphine and tri(4-fluorophenyl)phosphine, which show that the compounds are only toxic towards PC3 prostate cancer cells at high concentrations and at prolonged incubation periods and display IC50 values ..
  38. Souchek J, Davis A, Hill T, Holmes M, Qi B, Singh P, et al. Combination Treatment with Orlistat-Containing Nanoparticles and Taxanes Is Synergistic and Enhances Microtubule Stability in Taxane-Resistant Prostate Cancer Cells. Mol Cancer Ther. 2017;16:1819-1830 pubmed publisher
    ..and NanoOrl synergistically inhibited cell viability when combined with paclitaxel, docetaxel, and cabazitaxel in PC3-TxR and DU145-TxR cells, yet these combinations were also additive in parental lines...
  39. Kim M, Yoon H, Park S, Kim D, Pyo A, Kim H, et al. Engineering of monobody conjugates for human EphA2-specific optical imaging. PLoS ONE. 2017;12:e0180786 pubmed publisher
    ..coli. E1-Rluc8 and E1-EGFP specifically bound to hEphA2 in human prostate cancer PC3 cells but not in human cervical cancer HeLa cells, which express hEphA2 at high and low levels, respectively...
  40. Reddy T, Privér S, Mirzadeh N, Bhargava S. Synthesis of gold(I) phosphine complexes containing the 2-BrC6F4PPh2 ligand: Evaluation of anticancer activity in 2D and 3D spheroidal models of HeLa cancer cells. Eur J Med Chem. 2018;145:291-301 pubmed publisher
    ..ligand have been fully characterised and their anticancer activity towards five human tumor [prostate (PC3), glioblastoma (U87MG), cervical (HeLa), fibrosarcoma (HT1080), ovarian (SKOV-3)] and normal human embryonic kidney ..
  41. Moreira D, Zhang Q, Hossain D, Nechaev S, Li H, Kowolik C, et al. TLR9 signaling through NF-κB/RELA and STAT3 promotes tumor-propagating potential of prostate cancer cells. Oncotarget. 2015;6:17302-13 pubmed
    ..or silencing of TLR9 limits the clonogenic potential and mesenchymal stem cell-like properties of LNCaP- and PC3-derived prostate cancer cell variants...
  42. Wang L, Liu C, Li C, Xue J, Zhao S, Zhan P, et al. Effects of microRNA-221/222 on cell proliferation and apoptosis in prostate cancer cells. Gene. 2015;572:252-8 pubmed publisher
    ..Our results showed that miR-221/222 could promote the proliferation of prostate cancer cells, including LNCaP and PC3 cells...
  43. Dauchy R, Hoffman A, Wren Dail M, Hanifin J, Warfield B, Brainard G, et al. Daytime Blue Light Enhances the Nighttime Circadian Melatonin Inhibition of Human Prostate Cancer Growth. Comp Med. 2015;65:473-85 pubmed
    ..After implantation with tissue-isolated PC3 human prostate cancer xenografts, tumor latency-to-onset of growth and growth rates were markedly delayed, and ..
  44. Kucuksayan H, Ozes O, Akca H. Downregulation of SATB2 is critical for induction of epithelial-to-mesenchymal transition and invasion of NSCLC cells. Lung Cancer. 2016;98:122-129 pubmed publisher
    ..and TGF-? can induce EMT in these cells, however, TGF-? can not induce EMT in SATB2 expressing cells such as H1650, PC3, II-18, Hcc78 and Hcc193...
  45. Karakaya L, Akgul Y, Nalbantsoy A. Chemical constituents and in vitro biological activities of Eremurus spectabilis leaves. Nat Prod Res. 2017;31:1786-1791 pubmed publisher
    ..MCF-7 (Human breast adenocarcinoma), mPANC96 (Human pancreas adenocarcinoma), U87MG (Glioblastoma), PC3 (Prostate), CaCo-2 (Colon), HEK293 (Human embryonic kidney cells) cell lines. RAW 264...
  46. Mallepally R, Chintakuntla N, Putta V, K N, Vuradi R, P M, et al. Synthesis, Spectral Properties and DFT Calculations of new Ruthenium (II) Polypyridyl Complexes; DNA Binding Affinity and in Vitro Cytotoxicity Activity. J Fluoresc. 2017;27:1513-1530 pubmed publisher
    ..bromide (MTT) reduction assay, lactate dehydrogenase (LDH) release assay and reactive oxygen species (ROS) against selected cancer cell lines (HeLa, PC3, Lancap, MCF-7 and MD-MBA 231).
  47. Ribeiro N, Roy S, Butenko N, Cavaco I, Pinheiro T, Alho I, et al. New Cu(II) complexes with pyrazolyl derived Schiff base ligands: Synthesis and biological evaluation. J Inorg Biochem. 2017;174:63-75 pubmed publisher
    ..Their cytotoxic activity against two cancer cell lines (MCF7 - breast and PC3 - prostate) was also evaluated...
  48. Kim Y, Park S, Jang M. Targeted gene delivery of polyethyleneimine-grafted chitosan with RGD dendrimer peptide in ?v?3 integrin-overexpressing tumor cells. Carbohydr Polym. 2017;174:1059-1068 pubmed publisher
    ..as a targeting moiety suppressed the growth of a solid tumor mass in vivo mouse xenograft model generated with PC3 prostate tumor cells by silencing BCL2 mRNA...
  49. Leblanc A, Mercier N, Allain M, Dul M, Weber G, Geoffroy N, et al. A robust viologen and Mn-based porous coordination polymer with two types of Lewis acid sites providing high affinity for H2O, CO2 and NH3. Dalton Trans. 2017;46:15666-15670 pubmed publisher
    A novel porous coordination polymer [Mn(pc3)(H2O)2]·xH2O (3 < x < 4) is synthesized in water at pH = 7 using the anionic viologen-carboxylate ligand 4,4'-bipyridinium,1,1'-bis-(2,4-..
  50. Feng Q, He P, Wang Y. MicroRNA-223-3p regulates cell chemo-sensitivity by targeting FOXO3 in prostatic cancer. Gene. 2018;658:152-158 pubmed publisher
    ..In our present study, we found that miR-223-3p was up-regulated in PCa cell lines (C4-2, LNCap, PC3, DU-145)...
  51. Bamji Z, Washington K, Akinboye E, Bakare O, Kanaan Y, Copeland R. Apoptotic Effects of Novel Dithiocarbamate Analogs of Emetine in Prostate Cancer Cell Lines. Anticancer Res. 2015;35:4723-32 pubmed
    ..methods of cell flow cytometry were used to analyze apoptotic potential in prostate cancer cell lines (DU145, PC3 and LNCaP) and real time-polymerase chain reaction (PCR) for identifying key genes mediating apoptosis...
  52. Hao H, Chen W, Zhu J, Lu C, Shen Y. Design and synthesis of 2-phenylnaphthalenoids and 2-phenylbenzofuranoids as DNA topoisomerase inhibitors and antitumor agents. Eur J Med Chem. 2015;102:277-87 pubmed publisher
    ..3 to above 20 μM against MDA-MB-231, MDA-MB-435, HepG2 and PC3 cell lines...
  53. Jakimov D, Kojić V, Aleksić L, Bogdanović G, Ajduković J, Djurendić E, et al. Androstane derivatives induce apoptotic death in MDA-MB-231 breast cancer cells. Bioorg Med Chem. 2015;23:7189-98 pubmed publisher
    ..impact was examined on six human tumor cell lines, including two types of breast (MCF-7 and MDA-MB-231), prostate (PC3), cervical (HeLa), colon (HT 29) and lung cancer (A549), as well as one normal fetal lung fibroblasts cell line (..
  54. Law B, Mok S, Chan W, Xu S, Wu A, Yao X, et al. Hernandezine, a novel AMPK activator induces autophagic cell death in drug-resistant cancers. Oncotarget. 2016;7:8090-104 pubmed publisher
    ..and hernandezine, putatively induce cytotoxicity against a repertoire of cancer cell lines (HeLa, A549, MCF-7, PC3, HepG2, Hep3B and H1299)...
  55. Ronquist K, Sanchez C, Dubois L, Chioureas D, Fonseca P, Larsson A, et al. Energy-requiring uptake of prostasomes and PC3 cell-derived exosomes into non-malignant and malignant cells. J Extracell Vesicles. 2016;5:29877 pubmed publisher
    ..of extracellular vesicles (EVs) to generate ATP between normal seminal prostasomes and exosomes secreted by PC3 cells (PC3 exosomes), a prostate cancer cell line...
  56. Das L, Anderson T, Gard J, Sroka I, Strautman S, Nagle R, et al. Characterization of Laminin Binding Integrin Internalization in Prostate Cancer Cells. J Cell Biochem. 2017;118:1038-1049 pubmed publisher
    ..Silencing of α3 integrin protein expression in DU145, PC3, and PC3B1 cells resulted in up to a 1.71-fold increase in kactual for α6 integrin...
  57. Dangroo N, Singh J, Rath S, Gupta N, Qayum A, Singh S, et al. A convergent synthesis of novel alkyne-azide cycloaddition congeners of betulinic acid as potent cytotoxic agent. Steroids. 2017;123:1-12 pubmed publisher
    ..activity by MTT assay against five different human cancer cell lines: lung (A549), colon (HCT116), prostate (PC3), pancreatic (MIA PaCa-2) and breast (T47D)...
  58. Dueregger A, Schöpf B, Eder T, Höfer J, Gnaiger E, Aufinger A, et al. Differential Utilization of Dietary Fatty Acids in Benign and Malignant Cells of the Prostate. PLoS ONE. 2015;10:e0135704 pubmed publisher
    ..cells (RWPE-1) have a higher competence to utilize fatty acids as energy source than PCa cells (LNCaP, ABL, PC3) as shown not only by increased cell viability upon fatty acid supplementation but also by an increased ß-..
  59. Bacon T, Seiler C, Wolny M, Hughes R, Watson P, Schwabe J, et al. Histone deacetylase 3 indirectly modulates tubulin acetylation. Biochem J. 2015;472:367-77 pubmed publisher
    ..using MI192, a compound specific for HDAC3, modulated tubulin acetylation in the human prostate cancer cell line PC3. A brief 1 h treatment of PC3 cells with MI192 significantly increased levels of tubulin acetylation and ablated ..
  60. Colciago A, Mornati O, Ferri N, Castelnovo L, Fumagalli L, Bolchi C, et al. A selective alpha1D-adrenoreceptor antagonist inhibits human prostate cancer cell proliferation and motility "in vitro". Pharmacol Res. 2016;103:215-26 pubmed publisher
    ..by modifying the potent, but not subtype-selective alpha1-AR antagonist (S)-WB4101, in the hormone-refractory PC3 and DU145 PC cell lines...
  61. Tian H, Zhou Y, Yang G, Geng Y, Wu S, Hu Y, et al. Sulforaphane-cysteine suppresses invasion via downregulation of galectin-1 in human prostate cancer DU145 and PC3 cells. Oncol Rep. 2016;36:1361-8 pubmed publisher
    ..SFN-Cys), as a metabolite of SFN, inhibits invasion and possesses a novel mechanism in prostate cancer DU145 and PC3 cells...
  62. Valentino A, Calarco A, Di Salle A, Finicelli M, Crispi S, Calogero R, et al. Deregulation of MicroRNAs mediated control of carnitine cycle in prostate cancer: molecular basis and pathophysiological consequences. Oncogene. 2017;36:6030-6040 pubmed publisher
    ..of the miRNAs mentioned above affected tumorigenic properties, such as proliferation, migration and invasion, in PC3 and LNCaP cells regardless of their hormone sensitivity...
  63. Lin C, Chen C, Lin C, Cheng C, Lee C, Hsieh Y. Norcantharidin induces mitochondrial-dependent apoptosis through Mcl-1 inhibition in human prostate cancer cells. Biochim Biophys Acta Mol Cell Res. 2017;1864:1867-1876 pubmed publisher
    ..In vivo xenograft analysis revealed that NCTD significantly reduced tumor growth in mice with PC3 tumor xenografts...
  64. Xiong J, Lin R, Bu R, Liu Z, Yang Z, Yu L. A Micro-Damage Detection Method of Litchi Fruit Using Hyperspectral Imaging Technology. Sensors (Basel). 2018;18: pubmed publisher
    ..characteristics, with the results of wavelengths corresponding to the local extremum for the weight coefficient of PC3, i.e., 694, 725 and 798 nm. Then the single-band images corresponding to each sensitive wavelength were analyzed...
  65. Park S, Park S, Kim D, Pyo A, Kimura R, Sathirachinda A, et al. Isolation and Characterization of a Monobody with a Fibronectin Domain III Scaffold That Specifically Binds EphA2. PLoS ONE. 2015;10:e0132976 pubmed publisher
    ..In vivo optical imaging showed strong targeting of Cy5.5-labeled E1 to mouse tumor tissue induced by PC3 cells, a human prostate cancer cell line that expresses a high level of hEphA2...
  66. Mukherjee A, Kumar B, Hatano K, Russell L, Trock B, Searson P, et al. Development and Application of a Novel Model System to Study "Active" and "Passive" Tumor Targeting. Mol Cancer Ther. 2016;15:2541-2550 pubmed
    ..Two isogenic tumor pairs were applied, PC3 ± PSMA (PC3-PIP/PC3-Flu) or LMD-MDA-MB-231 ± PSMA (LMD-PSMA/LMD)...
  67. Mohamad M, Wahab N, Yunus R, Murad N, Zainuddin Z, Sundaram M, et al. Roles of MicroRNA21 and MicroRNA29a in Regulating Cell Adhesion Related Genes in Bone Metastasis Secondary to Prostate Cancer. Asian Pac J Cancer Prev. 2016;17:3437-45 pubmed
    ..Targeted genes would be upregulated upon transfection of the bone metastatic prostate cancer cell line, PC3, with specific microRNA inhibitors. MicroRNA software predicted that miR21 targets VCL while miR29a targets CX3CL1...
  68. Qi Y, Wu L, Li Z, Wu M, Wang H, Chan K, et al. Nodal signaling modulates the expression of Oct-4 via nuclear translocation of β-catenin in lung and prostate cancer cells. Arch Biochem Biophys. 2016;608:34-41 pubmed publisher
    ..or blocked Nodal/ALKs signaling pathway in non-small cell lung cancer cells A549 and prostate cancer cells PC3. Functionally, Nodal also increased the proliferation via the β-catenin nuclear translocation...
  69. Erdogan S, Türkekul K, Serttas R, Erdogan Z. The natural flavonoid apigenin sensitizes human CD44+ prostate cancer stem cells to cisplatin therapy. Biomed Pharmacother. 2017;88:210-217 pubmed publisher
    ..A CD44+ subpopulation was isolated from human androgen-independent PC3 PCa cells by using human CD44-PE antibody. IC50 values were determined by MTT test...
  70. Panic A, Ketteler J, Reis H, Sak A, Herskind C, Maier P, et al. Progression-related loss of stromal Caveolin 1 levels fosters the growth of human PC3 xenografts and mediates radiation resistance. Sci Rep. 2017;7:41138 pubmed publisher
    ..Silencing of Cav1 expression in PC3 cells resulted in increased tumor growth and a reduced growth delay after IR when compared to tumors generated by ..
  71. Yadav S, Li J, Stockert J, Herzog B, O CONNOR J, Garzon Manco L, et al. Induction of Neuroendocrine Differentiation in Prostate Cancer Cells by Dovitinib (TKI-258) and its Therapeutic Implications. Transl Oncol. 2017;10:357-366 pubmed publisher
    ..The NE differentiation was also observed when mice harboring PC3-xenografted tumors were systemically treated with Dovitinib...
  72. Seim I, Jeffery P, Thomas P, Nelson C, Chopin L. Whole-Genome Sequence of the Metastatic PC3 and LNCaP Human Prostate Cancer Cell Lines. G3 (Bethesda). 2017;7:1731-1741 pubmed publisher
    The bone metastasis-derived PC3 and the lymph node metastasis-derived LNCaP prostate cancer cell lines are widely studied, having been described in thousands of publications over the last four decades...
  73. Xia L, Zeh R, Mizelle J, Newton A, Predina J, Nie S, et al. Near-infrared Intraoperative Molecular Imaging Can Identify Metastatic Lymph Nodes in Prostate Cancer. Urology. 2017;106:133-138 pubmed publisher
    ..A prostate cancer cell line PC3 was used to establish xenograft model in NOD/SCID mice...
  74. Lin J, Wang Z, De W, Zheng M, Xu W, Wu H, et al. Targeting AXL overcomes resistance to docetaxel therapy in advanced prostate cancer. Oncotarget. 2017;8:41064-41077 pubmed publisher
    ..that AXL is overexpressed and activated independent of Gas6 in docetaxel-resistant prostate cancer cells (PC3-DR and DU145-DR)...
  75. Zhu Q, Li Z, Mu L, Zeng X, Redshaw C, Wei G. A quinoline-based fluorometric and colorimetric dual-modal pH probe and its application in bioimaging. Spectrochim Acta A Mol Biomol Spectrosc. 2018;188:230-236 pubmed publisher
    ..Furthermore, the application of probe 1 for the imaging of live PC3 cells was successfully achieved...
  76. Bellezza I, Scarpelli P, Pizzo S, Grottelli S, Costanzi E, Minelli A. ROS-independent Nrf2 activation in prostate cancer. Oncotarget. 2017;8:67506-67518 pubmed publisher
    ..We showed GRP78/BiP translocation to PC3 cell surface in the presence of tunicamycin, an ER stress inductor, and demonstrated the existence of a GRP78/BiP-..
  77. Wen S, Shang Z, Zhu S, Chang C, Niu Y. Androgen receptor enhances entosis, a non-apoptotic cell death, through modulation of Rho/ROCK pathway in prostate cancer cells. Prostate. 2013;73:1306-15 pubmed publisher
    ..b>PC3-AR9 cell line was also established after stably transfecting full-length AR-cDNA into PC3 cells...
  78. Richardsen E, Ness N, Melbø Jørgensen C, Johannesen C, Grindstad T, Nordbakken C, et al. The prognostic significance of CXCL16 and its receptor C-X-C chemokine receptor 6 in prostate cancer. Am J Pathol. 2015;185:2722-30 pubmed publisher
    ..Survival analyses were used to evaluate their prognostic impact. Expression of CXCL16 in PC cell lines (DU145 and PC3) and the effect on proliferation and migration were examined...
  79. Yang S, Long M, Tachado S, Seng S. Cigarette smoke modulates PC3 prostate cancer cell migration by altering adhesion molecules and the extracellular matrix. Mol Med Rep. 2015;12:6990-6 pubmed publisher
    ..cigarette smoke medium (SM) on cell migration and on the expression of ECM‑ and CAM‑related genes in PC3 prostate adenocarcinoma cells was investigated...
  80. Liu N, Mei L, Fan X, Tang C, Ji X, Hu X, et al. Phosphodiesterase 5/protein kinase G signal governs stemness of prostate cancer stem cells through Hippo pathway. Cancer Lett. 2016;378:38-50 pubmed publisher
    ..transcription regulator protein-1 (TAZ), a core effector of Hippo pathway, are highly expressed in the PC3-derived cancer stem cells (PCSC)...
  81. Shi Z, Wu D, Tang R, Li X, Chen R, Xue S, et al. Silencing of HMGA2 promotes apoptosis and inhibits migration and invasion of prostate cancer cells. J Biosci. 2016;41:229-36 pubmed
    ..interfering RNA (siRNA) targeted on human HMGA2 was transfected to suppress the HMGA2 expression in prostate cancer PC3 and DU145 cells, and then the cellular biology changes after decreased the expression of HMGA2 was examined...
  82. Liu C, Lu J, Tian H, Du W, Zhao L, Feng J, et al. Increased expression of PD?L1 by the human papillomavirus 16 E7 oncoprotein inhibits anticancer immunity. Mol Med Rep. 2017;15:1063-1070 pubmed publisher
    ..Overexpressing HPV16E7 oncoprotein in the epithelial carcinoma of PC3 cells increased the expression level of the PD?L1 protein and inhibited peripheral blood mononuclear cell (PBMC) ..
  83. Li P, Miao C, Liang C, Shao P, Wang Z, Li J. Silencing CAPN2 Expression Inhibited Castration-Resistant Prostate Cancer Cells Proliferation and Invasion via AKT/mTOR Signal Pathway. Biomed Res Int. 2017;2017:2593674 pubmed publisher
    The mRNA expression of CAPN2 was upregulated in CRPC cells (DU145 and PC3) than that in non-CRPC cells. Silencing CAPN2 expression could inhibit DU145 and PC3 cells proliferation by cell cycle arrest at G1 phase...
  84. Campbell S, Murray J, Delgoda R, Gallimore W. Two New Oxodolastane Diterpenes from the Jamaican Macroalga Canistrocarpus cervicornis. Mar Drugs. 2017;15: pubmed publisher
    ..Compounds 1-3 were evaluated for their cytotoxicity against human tumor cell lines PC3 and HT29...
  85. Liu F, Wang J, Fu Q, Zhang X, Wang Y, Liu J, et al. VEGF-activated miR-144 regulates autophagic survival of prostate cancer cells against Cisplatin. Tumour Biol. 2015;: pubmed
    ..In this study, we found that cisplatin dose-dependently activated Beclin-1 in two PC cell lines, PC3 and LNCap...
  86. Li M, Wang Y, Luo Y, Zhao J, Li Q, Zhang J, et al. Hypoxia inducible factor-1?-dependent epithelial to mesenchymal transition under hypoxic conditions in prostate cancer cells. Oncol Rep. 2016;36:521-7 pubmed publisher
    ..out to test typical epithelial to mesenchymal transition under hypoxia and the key regulators of this process in PC3, a human prostate cancer cell line...
  87. Miryala B, Godeshala S, Grandhi T, Christensen M, Tian Y, Rege K. Aminoglycoside-derived amphiphilic nanoparticles for molecular delivery. Colloids Surf B Biointerfaces. 2016;146:924-37 pubmed publisher
    ..that mPEG-PAE nanoparticles, loaded with doxorubicin, were able to induce significant loss in viabilities of PC3 human prostate cancer, MDA-MB-231 human breast cancer, and MB49 murine bladder cancer cells; empty nanoparticles ..
  88. Bello B, Khan S, Khan J, Syed F, Mirza M, Shah L, et al. Anticancer, antibacterial and pollutant degradation potential of silver nanoparticles from Hyphaene thebaica. Biochem Biophys Res Commun. 2017;490:889-894 pubmed publisher
    ..The anti-proliferation activity of the synthesized AgNps was carried out using MTT assay on human prostate (PC3), breast (MCF7) and liver (HepG2) cancer cell lines...
  89. Green M, Seidel J, Williams M, Wong K, Ton A, Basuli F, et al. Comparison of planar, PET and well-counter measurements of total tumor radioactivity in a mouse xenograft model. Nucl Med Biol. 2017;53:29-36 pubmed publisher
    ..Forty-one athymic mice were implanted with PC3 human prostate cancer cells transfected with prostate-specific membrane antigen (PSMA (+)) and one additional ..
  90. Pillat M, Lameu C, Trujillo C, Glaser T, Cappellari A, Negraes P, et al. Bradykinin promotes neuron-generating division of neural progenitor cells through ERK activation. J Cell Sci. 2016;129:3437-48 pubmed publisher
    ..bradykinin lengthened the G1-phase of the neural progenitor cells (NPC) cycle and increased TIS21 (also known as PC3 and BTG2) expression in hippocampus from newborn mice...
  91. Agnoli K, Freitag R, Gomes M, Jenul C, Suppiger A, Mannweiler O, et al. Use of Synthetic Hybrid Strains To Determine the Role of Replicon 3 in Virulence of the Burkholderia cepacia Complex. Appl Environ Microbiol. 2017;83: pubmed publisher
    ..The third replicon of the Bcc, megaplasmid pC3 (0.5 to 1...
  92. Lackova Z, Buchtelova H, Buchtova Z, Klejdus B, Heger Z, Brtnický M, et al. Anticarcinogenic Effect of Spices Due to Phenolic and Flavonoid Compounds-In Vitro Evaluation on Prostate Cells. Molecules. 2017;22: pubmed publisher
    ..shows the effects of spices, and their phenolic and flavonoid compounds, on prostate cell lines (PNT1A, 22RV1 and PC3)...