Gene Symbol: ACTG1
Description: actin gamma 1
Alias: ACT, ACTG, DFNA20, DFNA26, HEL-176, actin, cytoplasmic 2, cytoskeletal gamma-actin, epididymis luminal protein 176
Species: human
Products:     ACTG1

Top Publications

  1. Warrilow D, Harrich D. HIV-1 replication from after cell entry to the nuclear periphery. Curr HIV Res. 2007;5:293-9 pubmed
    ..An actin-transport process may then facilitate the remaining short journey to the nuclear membrane. ..
  2. Gordón Alonso M, Rocha Perugini V, Alvarez S, Moreno Gonzalo O, Ursa A, López Martín S, et al. The PDZ-adaptor protein syntenin-1 regulates HIV-1 entry. Mol Biol Cell. 2012;23:2253-63 pubmed publisher
  3. Ibarrondo F, Choi R, Geng Y, Canon J, Rey O, Baldwin G, et al. HIV type 1 Gag and nucleocapsid proteins: cytoskeletal localization and effects on cell motility. AIDS Res Hum Retroviruses. 2001;17:1489-500 pubmed
    ..These data suggest that interactions between HIV-1 Gag and actin in infected cells enhance cell motility. Ultimately this enhanced motility of infected cells could promote the dissemination of virus into the brain and other tissues. ..
  4. Morín M, Bryan K, Mayo Merino F, Goodyear R, Mencia A, Modamio Høybjør S, et al. In vivo and in vitro effects of two novel gamma-actin (ACTG1) mutations that cause DFNA20/26 hearing impairment. Hum Mol Genet. 2009;18:3075-89 pubmed publisher
    ..of deafness-associated gamma-actin mutants and support the hypothesis that the post-lingual and progressive nature of the DFNA20/26 hearing loss is the result of a progressive deterioration of the hair cell cytoskeleton over time.
  5. Jolly C, Mitar I, Sattentau Q. Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and spread of human immunodeficiency virus type 1. J Virol. 2007;81:5547-60 pubmed
    ..Based on these data, we propose that HIV-1 requires both actin and tubulin components of the T-cell cytoskeleton to direct its assembly and budding and to elaborate a functional VS. ..
  6. Rivière J, van Bon B, Hoischen A, Kholmanskikh S, O Roak B, Gilissen C, et al. De novo mutations in the actin genes ACTB and ACTG1 cause Baraitser-Winter syndrome. Nat Genet. 2012;44:440-4, S1-2 pubmed publisher
    ..proband-parent trios, we identified de novo missense changes in the cytoplasmic actin-encoding genes ACTB and ACTG1 in one and two probands, respectively...
  7. Wilk T, Gowen B, Fuller S. Actin associates with the nucleocapsid domain of the human immunodeficiency virus Gag polyprotein. J Virol. 1999;73:1931-40 pubmed
    ..The same result was obtained when mature HIV-1 particles were disrupted with detergent. Taken together, these results indicate that actin molecules are associated with the NC domain of the viral polyprotein. ..
  8. Tzima E, Trotter P, Orchard M, Walker J. Annexin V relocates to the platelet cytoskeleton upon activation and binds to a specific isoform of actin. Eur J Biochem. 2000;267:4720-30 pubmed
    ..The results of this study suggest a model in which annexin V that relocates to the plasma membrane and binds to gamma-actin in an activation-dependent manner forms a strong association with the platelet cytoskeleton. ..
  9. Stolp B, Abraham L, Rudolph J, Fackler O. Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling. J Virol. 2010;84:3935-48 pubmed publisher

More Information


  1. Liu P, Li H, Ren X, Mao H, Zhu Q, Zhu Z, et al. Novel ACTG1 mutation causing autosomal dominant non-syndromic hearing impairment in a Chinese family. J Genet Genomics. 2008;35:553-8 pubmed publisher
    The gamma-actin (ACTG1) gene is a cytoplasmic nonmuscle actin gene, which encodes a major cytoskeletal protein in the sensory hair cells of the cochlea...
  2. Zhu M, Yang T, Wei S, DeWan A, Morell R, Elfenbein J, et al. Mutations in the gamma-actin gene (ACTG1) are associated with dominant progressive deafness (DFNA20/26). Am J Hum Genet. 2003;73:1082-91 pubmed
    ..Cochlear-expressed genes were sequenced in affected family members. Sequence analysis of the gamma-actin gene (ACTG1) revealed missense mutations in highly conserved actin domains in all four families...
  3. Vasiliver Shamis G, Cho M, Hioe C, Dustin M. Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapse. J Virol. 2009;83:11341-55 pubmed publisher
    ..However, these partial TCR signals act locally to create an F-actin-depleted zone...
  4. Dugina V, Zwaenepoel I, Gabbiani G, Clement S, Chaponnier C. Beta and gamma-cytoplasmic actins display distinct distribution and functional diversity. J Cell Sci. 2009;122:2980-8 pubmed publisher
    ..Our results reveal new aspects of beta- and gamma-actin organization that support their functional diversity. ..
  5. Uruno T, Liu J, Zhang P, Fan Yx -, Egile C, Li R, et al. Activation of Arp2/3 complex-mediated actin polymerization by cortactin. Nat Cell Biol. 2001;3:259-66 pubmed
    ..Our data indicate a new mechanism for activation of actin polymerization involving an enhanced interaction between the Arp2/3 complex and actin filaments. ..
  6. Bukrinskaya A, Brichacek B, Mann A, Stevenson M. Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton. J Exp Med. 1998;188:2113-25 pubmed
  7. Rendtorff N, Zhu M, Fagerheim T, Antal T, Jones M, Teslovich T, et al. A novel missense mutation in ACTG1 causes dominant deafness in a Norwegian DFNA20/26 family, but ACTG1 mutations are not frequent among families with hereditary hearing impairment. Eur J Hum Genet. 2006;14:1097-105 pubmed ACTG1 were found to cause autosomal dominant, progressive, sensorineural hearing impairment linked to the DFNA20/26 locus on chromosome 17q25.3 in four American families and in one Dutch family...
  8. Fackler O, Kienzle N, Kremmer E, Boese A, Schramm B, Klimkait T, et al. Association of human immunodeficiency virus Nef protein with actin is myristoylation dependent and influences its subcellular localization. Eur J Biochem. 1997;247:843-51 pubmed
    ..This novel interaction of HIV-1 Nef with actin provides insight into the association of Nef with cellular structures and reveals general differences in the interactions of the Nef proteins from HIV-1 and HIV-2. ..
  9. Park G, Gim J, Kim A, Han K, Kim H, Oh S, et al. Multiphasic analysis of whole exome sequencing data identifies a novel mutation of ACTG1 in a nonsyndromic hearing loss family. BMC Genomics. 2013;14:191 pubmed publisher
    ..Finally, the novel variant p.M305T in ACTG1 (DFNA20/26) was selected as a disease-causing variant...
  10. Rey O, Canon J, Krogstad P. HIV-1 Gag protein associates with F-actin present in microfilaments. Virology. 1996;220:530-4 pubmed
    ..In vivo and in vitro analyses of this interaction indicated that the unprocessed Gag polyprotein is capable of association with polymerized actin (F-actin). Binding of Gag to F-actin may be involved in the assembly or budding of HIV-1. ..
  11. Hertzog M, van Heijenoort C, Didry D, Gaudier M, Coutant J, Gigant B, et al. The beta-thymosin/WH2 domain; structural basis for the switch from inhibition to promotion of actin assembly. Cell. 2004;117:611-23 pubmed
  12. van Wijk E, Krieger E, Kemperman M, De Leenheer E, Huygen P, Cremers C, et al. A mutation in the gamma actin 1 (ACTG1) gene causes autosomal dominant hearing loss (DFNA20/26). J Med Genet. 2003;40:879-84 pubmed
    ..with autosomal dominant hearing loss yielded a chromosomal localisation of the underlying genetic defect in the DFNA20/26 locus at 17q25-qter...
  13. Otterbein L, Graceffa P, Dominguez R. The crystal structure of uncomplexed actin in the ADP state. Science. 2001;293:708-11 pubmed
    ..The successful crystallization of monomeric actin opens the way to future structure determinations of actin complexes with actin-binding proteins such as myosin. ..
  14. Readinger J, Schiralli G, Jiang J, Thomas C, August A, Henderson A, et al. Selective targeting of ITK blocks multiple steps of HIV replication. Proc Natl Acad Sci U S A. 2008;105:6684-9 pubmed publisher
    ..Our data suggest that inhibition of ITK blocks HIV infection by affecting multiple steps of HIV replication. ..
  15. Ott D, Coren L, Kane B, Busch L, Johnson D, Sowder R, et al. Cytoskeletal proteins inside human immunodeficiency virus type 1 virions. J Virol. 1996;70:7734-43 pubmed
    ..The presence of these fragments, as well as the incorporation of a few specific cytoskeletal proteins into virions, suggests an active interaction between cytoskeletal and viral proteins. ..
  16. Spear M, Guo J, Wu Y. The trinity of the cortical actin in the initiation of HIV-1 infection. Retrovirology. 2012;9:45 pubmed publisher
    ..It is the purpose of this review to examine, in detail, the manifestation of viral dependence on the actin cytoskeleton, and present a model of how HIV utilizes actin dynamics to initiate infection. ..
  17. Liu B, Dai R, Tian C, Dawson L, Gorelick R, Yu X. Interaction of the human immunodeficiency virus type 1 nucleocapsid with actin. J Virol. 1999;73:2901-8 pubmed
  18. Morell R, Friderici K, Wei S, Elfenbein J, Friedman T, Fisher R. A new locus for late-onset, progressive, hereditary hearing loss DFNA20 maps to 17q25. Genomics. 2000;63:1-6 pubmed
    We report the localization of DFNA20, a gene causing dominant, nonsyndromic, progressive hearing loss in a three-generation Midwestern family, to chromosome 17q25...
  19. de Heer A, Huygen P, Collin R, Oostrik J, Kremer H, Cremers C. Audiometric and vestibular features in a second Dutch DFNA20/26 family with a novel mutation in ACTG1. Ann Otol Rhinol Laryngol. 2009;118:382-90 pubmed
    We analyzed the phenotype in a 5-generation DFNA20/26 family with a novel missense mutation in the ACTG1 gene (c.151G>A) and compared the findings to previous reports on DFNA20/26 families...
  20. Gladnikoff M, Shimoni E, Gov N, Rousso I. Retroviral assembly and budding occur through an actin-driven mechanism. Biophys J. 2009;97:2419-28 pubmed publisher
    ..The results of this study show that retroviruses utilize the cell cytoskeleton to expedite their assembly and budding. ..
  21. Yoder A, Yu D, Dong L, Iyer S, Xu X, Kelly J, et al. HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell. 2008;134:782-92 pubmed publisher
    ..Conversely, induction of active cofilin greatly facilitates it. These findings shed light on viral exploitation of cellular machinery in resting T cells, where chemokine receptor signaling becomes obligatory. ..
  22. Shen L, Tian S, Song H, Chen X, Guo H, Wan D, et al. Cytotoxic Tricycloalternarene Compounds from Endophyte Alternaria sp. W-1 Associated with Laminaria japonica. Mar Drugs. 2018;16: pubmed publisher
    ..3a (3), tricycloalternarene F (4), 15-hydroxyl tricycloalternarene 5b (5), and ACTG-Toxin D (6)...
  23. Kusner D, Barton J, Wen K, Wang X, Rubenstein P, Iyer S. Regulation of phospholipase D activity by actin. Actin exerts bidirectional modulation of Mammalian phospholipase D activity in a polymerization-dependent, isoform-specific manner. J Biol Chem. 2002;277:50683-92 pubmed
    ..These data are consistent with a model in which the physical state of the actin cytoskeleton is a critical determinant of its regulation of PLD activity. ..
  24. Izquierdo Useros N, Esteban O, Rodriguez Plata M, Erkizia I, Prado J, Blanco J, et al. Dynamic imaging of cell-free and cell-associated viral capture in mature dendritic cells. Traffic. 2011;12:1702-13 pubmed publisher
  25. Kumarasamy N, Aga E, Ribaudo H, Wallis C, Katzenstein D, Stevens W, et al. Lopinavir/Ritonavir Monotherapy as Second-line Antiretroviral Treatment in Resource-Limited Settings: Week 104 Analysis of AIDS Clinical Trials Group (ACTG) A5230. Clin Infect Dis. 2015;60:1552-8 pubmed publisher
    The AIDS Clinical Trials Group (ACTG) A5230 study evaluated lopinavir/ritonavir (LPV/r) monotherapy following virologic failure (VF) on first-line human immunodeficiency virus (HIV) regimens in Africa and Asia...
  26. Martins de Souza D, Gattaz W, Schmitt A, Maccarrone G, Hunyadi Gulyas E, Eberlin M, et al. Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia. J Psychiatr Res. 2009;43:978-86 pubmed publisher
    ..Our data not only reinforces the involvement of proteins previously implicated in schizophrenia, but also suggests new markers, providing further information to foster the comprehension of this important disease. ..
  27. Chen C, Kirshner J, Sherman M, Hu W, Nguyen T, Shively J. Mutation analysis of the short cytoplasmic domain of the cell-cell adhesion molecule CEACAM1 identifies residues that orchestrate actin binding and lumen formation. J Biol Chem. 2007;282:5749-60 pubmed
    ..These studies demonstrate that a short cytoplasmic domain membrane receptor can directly mediate substantial intracellular signaling. ..
  28. Jepsen L, Kruth K, Rubenstein P, Sept D. Two Deafness-Causing Actin Mutations (DFNA20/26) Have Allosteric Effects on the Actin Structure. Biophys J. 2016;111:323-332 pubmed publisher
    ..Taken together, these results indicate that mutations at this site give rise to a series of small changes that can be tolerated in vivo but result in misregulation of actin assembly and dynamics. ..
  29. Lee P, Midelfort C, Murakami K, Hatcher V. Multiple forms of ubiquitin-protein ligase. Binding of activated ubiquitin to protein substrates. Biochemistry. 1986;25:3134-8 pubmed
    ..In particular, a pair of substrates were identified from erythrocyte extracts which were far more efficient substrates than the denatured proteins exogenously added. ..
  30. Bar K, Sneller M, Harrison L, Justement J, Overton E, Petrone M, et al. Effect of HIV Antibody VRC01 on Viral Rebound after Treatment Interruption. N Engl J Med. 2016;375:2037-2050 pubmed
    ..We conducted two open-label trials (AIDS Clinical Trials Group [ACTG] A5340 and National Institutes of Health [NIH] 15-I-0140) of the safety, side-effect profile, pharmacokinetic ..
  31. Offenhauser N, Borgonovo A, Disanza A, Romano P, Ponzanelli I, Iannolo G, et al. The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway. Mol Biol Cell. 2004;15:91-8 pubmed
    ..Finally, the patterns of expression of eps8 and eps8L2 in mice are remarkably overlapping, thus providing a likely explanation for the lack of overt phenotype in eps8 null mice. ..
  32. Robertson K, Jiang H, Evans S, Marra C, Berzins B, Hakim J, et al. International neurocognitive normative study: neurocognitive comparison data in diverse resource-limited settings: AIDS Clinical Trials Group A5271. J Neurovirol. 2016;22:472-8 pubmed publisher
    ..Here, we report on ACTG 5271, which provided neurological training of clinical site personnel and collected neurocognitive normative ..
  33. Roghanian A, Jones D, Pattisapu J, Wolfe J, Young N, Behnam B. Filament-associated TSGA10 protein is expressed in professional antigen presenting cells and interacts with vimentin. Cell Immunol. 2010;265:120-6 pubmed publisher
    ..We propose that TSGA10 could influence the function of antigen presenting cells (APC) via its interaction with cytoskeletal proteins such as vimentin. ..
  34. Lyonnais S, Gorelick R, Heniche Boukhalfa F, Bouaziz S, Parissi V, Mouscadet J, et al. A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA. Virus Res. 2013;171:287-303 pubmed publisher
  35. Matarrese P, Conti L, Varano B, Gauzzi M, Belardelli F, Gessani S, et al. The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly. Cell Death Differ. 2000;7:25-36 pubmed
    ..e. by inducing anoikis-resistance. These particular effects of vpr might enhance the homing, spreading and survival of the infected lymphocytes, thus contributing to virus persistence in the course of acute HIV-1 infection. ..
  36. Yosimichi G, Kubota S, Hattori T, Nishida T, Nawachi K, Nakanishi T, et al. CTGF/Hcs24 interacts with the cytoskeletal protein actin in chondrocytes. Biochem Biophys Res Commun. 2002;299:755-61 pubmed
    ..These findings suggest that a significant portion of intracellular CTGF/Hcs24 may regulate certain cell biological events in chondrocytes through the interaction with this particular cytoskeletal protein. ..
  37. Chandrasekaran P, Buckley M, Moore V, Wang L, Kehrl J, Venkatesan S. HIV-1 Nef impairs heterotrimeric G-protein signaling by targeting G?(i2) for degradation through ubiquitination. J Biol Chem. 2012;287:41481-98 pubmed publisher
    ..By specifically degrading G?(i2), Nef directly subverts leukocyte migration and homing. Impaired trafficking and homing of HIV Nef-expressing lymphocytes probably contributes to early immune dysfunction following HIV infection. ..
  38. Fuchs E, Kim K, Hanukoglu I, Tanese N. The evolution and complexity of the genes encoding the cytoskeletal proteins of human epidermal cells. Curr Probl Dermatol. 1983;11:27-44 pubmed
    ..The availability of cloned cDNAs specific for each of three types of epithelial cytoskeletal proteins allows us to investigate the coordinate expression of their mRNAs during terminal differentiation in human epidermis. ..
  39. Mustapha M, Chouery E, Torchard Pagnez D, Nouaille S, Khrais A, Sayegh F, et al. A novel locus for Usher syndrome type I, USH1G, maps to chromosome 17q24-25. Hum Genet. 2002;110:348-50 pubmed
    ..The USH1G interval overlaps the intervals for two dominant forms of isolated hearing loss, namely DFNA20 and DFNA26. Since several examples have been reported of syndromic and isolated forms of deafness being allelic, USH1G, ..
  40. Martinez Quiles N, Rohatgi R, Anton I, Medina M, Saville S, Miki H, et al. WIP regulates N-WASP-mediated actin polymerization and filopodium formation. Nat Cell Biol. 2001;3:484-91 pubmed
    ..Our results indicate that WIP and N-WASP may act as a functional unit in filopodium formation, which is consistent with their role in actin-tail formation in cells ..
  41. Rainger J, Williamson K, Soares D, Truch J, Kurian D, Gillessen Kaesbach G, et al. A recurrent de novo mutation in ACTG1 causes isolated ocular coloboma. Hum Mutat. 2017;38:942-946 pubmed publisher
    ..Three of these genes encoded proteins associated with actin cytoskeleton dynamics: ACTG1, TWF1, and LCP1...
  42. Chang K, Yang P, Lai H, Yeh T, Chen T, Yeh C. Identification of a novel actin isoform in hepatocellular carcinoma. Hepatol Res. 2006;36:33-9 pubmed
    ..A novel class of actin isoforms was expressed in some hepatocellular carcinoma tissues, replacing beta-actins to become the major constituents of actin cytoskeleton. ..
  43. Krogstad P, Geng Y, Rey O, Canon J, Ibarrondo F, Ackerson B, et al. Human immunodeficiency virus nucleocapsid protein polymorphisms modulate the infectivity of RNA packaging mutants. Virology. 2002;294:282-8 pubmed
    ..Conservative amino acid differences between HXB2 and NL4-3 NCs were sufficient to explain the difference in infectivity of viruses carrying the R10A and K11A mutations. ..
  44. Zhang Q, Li Y, Howard T. Human lymphocyte-specific protein 1, the protein overexpressed in neutrophil actin dysfunction with 47-kDa and 89-kDa protein abnormalities (NAD 47/89), has multiple F-actin binding domains. J Immunol. 2000;165:2052-8 pubmed
    ..High KCl concentrations decrease full-length LSP1 binding to F-actin, suggesting the affinity between LSP1 and F-actin is mainly through electrostatic interaction. ..
  45. Gammoh E, Mahmood N, Madan S, Ebrahim B, Mustafa F, Almawi W. Transcription Factor-7-Like 2 Gene Variants Affect the Metabolic Phenotypes of Polycystic Ovary Syndrome. Ann Nutr Metab. 2015;67:228-35 pubmed publisher
    ..Four-locus (rs4506565-rs7903146, rs12243326, and rs12255372) haplotype analysis identified PCOS-susceptible (ACTG) and -protective (TTTG) haplotypes, which remained significant after controlling for multiple comparisons and for ..
  46. Kiuchi T, Nagai T, Ohashi K, Mizuno K. Measurements of spatiotemporal changes in G-actin concentration reveal its effect on stimulus-induced actin assembly and lamellipodium extension. J Cell Biol. 2011;193:365-80 pubmed publisher
  47. La Rosa A, Harrison L, Taiwo B, Wallis C, Zheng L, Kim P, et al. Raltegravir in second-line antiretroviral therapy in resource-limited settings (SELECT): a randomised, phase 3, non-inferiority study. Lancet HIV. 2016;3:e247-58 pubmed publisher
    ..A5273 was a randomised, open-label, phase 3, non-inferiority study at 15 AIDS Clinical Trials Group (ACTG) research sites in nine resource-limited countries (three sites each in India and South Africa, two each in Malawi ..
  48. Bretscher A, Weber K. Villin is a major protein of the microvillus cytoskeleton which binds both G and F actin in a calcium-dependent manner. Cell. 1980;20:839-47 pubmed
  49. Meng X, Yin K, Wang J, Dong P, Liu L, Shen Y, et al. Effect of CYP2B6 Gene Polymorphisms on Efavirenz Plasma Concentrations in Chinese Patients with HIV Infection. PLoS ONE. 2015;10:e0130583 pubmed publisher
    ..The frequencies of the five haplotypes (high to low) were as follows: CCTG (0.328), ACTG (0.280), ACCT (0.189), ATTG (0.186) and ACCG (0.017). The frequency of CCTG (0...
  50. Tomasselli A, Hui J, Adams L, Chosay J, Lowery D, Greenberg B, et al. Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus. J Biol Chem. 1991;266:14548-53 pubmed
  51. Roof D, Hayes A, Adamian M, Chishti A, Li T. Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein. J Cell Biol. 1997;138:575-88 pubmed
    ..The developmental time course of abLIM expression in the retina suggests that the retina-specific isoform may have a specialized role in the development or elaboration of photoreceptor inner and outer segments. ..
  52. Kemerley A, Sloan C, Pfeifer W, Smith R, Drack A. A novel mutation in ACTG1 causing Baraitser-Winter syndrome with extremely variable expressivity in three generations. Ophthalmic Genet. 2017;38:152-156 pubmed publisher
    ..This syndrome is caused by missense mutations in the genes ACTB or ACTG1, both of which encode for cytoplasmic actin proteins crucial for proper development of many organs in the human ..
  53. Luo H, Yao L, Zhang Y, Li R. Liquid chromatography-mass spectrometry-based quantitative proteomics analysis reveals chondroprotective effects of astragaloside IV in interleukin-1β-induced SW1353 chondrocyte-like cells. Biomed Pharmacother. 2017;91:796-802 pubmed publisher
    ..Bioinformatics analysis revealed that gamma actin 1 (ACTG1) and Yes Associated Protein 1 (YAP1), participating in the Hippo signaling pathway and Vitronectin (VTN) and ..
  54. Xiang Y, Zheng K, Ju H, Wang S, Pei Y, Ding W, et al. Cofilin 1-mediated biphasic F-actin dynamics of neuronal cells affect herpes simplex virus 1 infection and replication. J Virol. 2012;86:8440-51 pubmed publisher
    ..These results may provide insight into the mechanism by which HSV-1 productively infects neuronal cells and causes pathogenesis. ..
  55. Celum C, Hong T, Cent A, Donnell D, Morrow R, Baeten J, et al. Herpes Simplex Virus Type 2 Acquisition Among HIV-1-Infected Adults Treated With Tenofovir Disoproxyl Fumarate as Part of Combination Antiretroviral Therapy: Results From the ACTG A5175 PEARLS Study. J Infect Dis. 2017;215:907-910 pubmed publisher
    ..42 and 6.63 cases/100 person-years, respectively; hazard ratio, 0.89; 95% confidence interval, .55-1.44). HSV-2 acquisition was not reduced in HIV-infected, HSV-2-uninfected persons during TDF-containing ART. ..
  56. Provost P, Doucet J, Hammarberg T, Gerisch G, Samuelsson B, Radmark O. 5-Lipoxygenase interacts with coactosin-like protein. J Biol Chem. 2001;276:16520-7 pubmed
    ..Moreover, 5LO was found to interfere with actin polymerization. Our results indicate that the 5LO-CLP and CLP-F-actin interactions are mutually exclusive and suggest a modulatory role for 5LO in actin dynamics. ..
  57. Miyoshi K, Honda A, Baba K, Taniguchi M, Oono K, Fujita T, et al. Disrupted-In-Schizophrenia 1, a candidate gene for schizophrenia, participates in neurite outgrowth. Mol Psychiatry. 2003;8:685-94 pubmed
    ..As there is a high level of DISC1 expression in developing rat brain, dysfunction of DISC1 may confer susceptibility to psychiatric illnesses through abnormal development of the nervous system. ..
  58. Hearps A, Jans D. Regulating the functions of the HIV-1 matrix protein. AIDS Res Hum Retroviruses. 2007;23:341-6 pubmed
    ..J Virol 2005;79:13028-13036) confirms the importance of this protein for HIV infection and highlights a potentially new avenue in multivalent drug therapy. ..
  59. Pedrotti B, Colombo R, Islam K. Microtubule associated protein MAP1A is an actin-binding and crosslinking protein. Cell Motil Cytoskeleton. 1994;29:110-6 pubmed
    ..The widespread distribution of MAP1A and its interaction with microtubules, actin, and intermediate filaments suggests that it may constitute an important determinant of neuronal and non-neuronal cellular morphology. ..
  60. Anand A, Zhao H, Nagaraja T, Robinson L, Ganju R. N-terminal Slit2 inhibits HIV-1 replication by regulating the actin cytoskeleton. Retrovirology. 2013;10:2 pubmed publisher
    ..Our study, thus, provides insights into the role of Slit2N in HIV-1 infection and underscores its potential in limiting viral replication in T-cells...
  61. Chou C, Davis R, Fuller M, Slovin J, Wong A, Wright J, et al. Gamma-actin: unusual mRNA 3'-untranslated sequence conservation and amino acid substitutions that may be cancer related. Proc Natl Acad Sci U S A. 1987;84:2575-9 pubmed
    ..g., myc and simian virus 40 large tumor antigen) and growth factor/receptor/protein kinase-related (e.g., sis, erbB, and ras) types of oncogenes. ..
  62. Andra K, Nikolic B, Stöcher M, Drenckhahn D, Wiche G. Not just scaffolding: plectin regulates actin dynamics in cultured cells. Genes Dev. 1998;12:3442-51 pubmed
    ..These results reveal a novel role of plectin as regulator of cellular processes involving actin filament dynamics that goes beyond its proposed role in scaffolding and mechanical stabilization of cells. ..
  63. Shoeman R, Kesselmier C, Mothes E, Höner B, Traub P. Non-viral cellular substrates for human immunodeficiency virus type 1 protease. FEBS Lett. 1991;278:199-203 pubmed
  64. Touyz R, Yao G, Schiffrin E. Role of the actin cytoskeleton in angiotensin II signaling in human vascular smooth muscle cells. Can J Physiol Pharmacol. 2005;83:91-7 pubmed
    ..Together, these studies suggest that the cytoskeleton may be a central point of crosstalk in growth- and redox-signaling pathways by Ang II, which may be important in the regulation of VSMC function. ..
  65. Danilewicz M, Wagrowska Danilewicz M. Immunohistochemical analysis of transforming growth factor beta-1 in AA and AL renal amyloidosis. Pol J Pathol. 2006;57:193-8 pubmed
    ..In conclusion, our study suggests a role of transforming growth factor beta-1 in interstitial fibrotic changes in renal AA and AL amyloidosis and we hypothesize that myofibroblast pathway may be important in this process. ..
  66. Gaucher J, Maugé C, Didry D, Guichard B, Renault L, Carlier M. Interactions of isolated C-terminal fragments of neural Wiskott-Aldrich syndrome protein (N-WASP) with actin and Arp2/3 complex. J Biol Chem. 2012;287:34646-59 pubmed publisher
    ..VCA·Arp2/3 binds one actin in a latrunculin A-sensitive fashion, in a 1:1:1 complex, indicating that binding of the second actin to VCA is weakened in the ternary complex. ..
  67. Hesterberg L, Weber K. Isolation of a domain of villin retaining calcium-dependent interaction with G-actin, but devoid of F-actin fragmenting activity. Eur J Biochem. 1986;154:135-40 pubmed
  68. Fröbel J, Cadeddu R, Hartwig S, Bruns I, Wilk C, Kundgen A, et al. Platelet proteome analysis reveals integrin-dependent aggregation defects in patients with myelodysplastic syndromes. Mol Cell Proteomics. 2013;12:1272-80 pubmed publisher
  69. Van Troys M, Dewitte D, Goethals M, Carlier M, Vandekerckhove J, Ampe C. The actin binding site of thymosin beta 4 mapped by mutational analysis. EMBO J. 1996;15:201-10 pubmed
    ..The residues critical for contacting actin are conserved throughout the beta-thymosin family and in addition to this we identify a similar pattern in the C-terminal headpiece of villin and dematin. ..
  70. Hawkins M, Pope B, Maciver S, Weeds A. Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments. Biochemistry. 1993;32:9985-93 pubmed
    ..By contrast, at pH values below 7, ADF binds to actin filaments in a highly cooperative manner and at a 1:1 ratio to filament subunits. When the pH is raised to 8.0, the decorated filaments are rapidly severed and depolymerized. ..
  71. Wu R, Gu Y, Xu Y, Mitola S, Bussolino F, Terada L. Human immunodeficiency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant production. J Virol. 2004;78:779-89 pubmed
    ..We conclude that Tat induces actin cytoskeletal rearrangements through PAK1 and downstream activation of the endothelial NADPH oxidase. ..
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