ACTC1

Summary

Gene Symbol: ACTC1
Description: actin, alpha, cardiac muscle 1
Alias: ACTC, ASD5, CMD1R, CMH11, LVNC4, actin, alpha cardiac muscle 1
Species: human
Products:     ACTC1

Top Publications

  1. Ott D, Coren L, Kane B, Busch L, Johnson D, Sowder R, et al. Cytoskeletal proteins inside human immunodeficiency virus type 1 virions. J Virol. 1996;70:7734-43 pubmed
    ..The presence of these fragments, as well as the incorporation of a few specific cytoskeletal proteins into virions, suggests an active interaction between cytoskeletal and viral proteins. ..
  2. Readinger J, Schiralli G, Jiang J, Thomas C, August A, Henderson A, et al. Selective targeting of ITK blocks multiple steps of HIV replication. Proc Natl Acad Sci U S A. 2008;105:6684-9 pubmed publisher
    ..Our data suggest that inhibition of ITK blocks HIV infection by affecting multiple steps of HIV replication. ..
  3. Jiang H, Qiu G, Li Ling J, Xin N, Sun K. Reduced ACTC1 expression might play a role in the onset of congenital heart disease by inducing cardiomyocyte apoptosis. Circ J. 2010;74:2410-8 pubmed
    The Cardiac ? actin 1 gene (ACTC1) has been related to familial atrial septal defects. This study was set to explore a potential role of this gene in the formation of sporadic congenital heart disease (CHD)...
  4. Rey O, Canon J, Krogstad P. HIV-1 Gag protein associates with F-actin present in microfilaments. Virology. 1996;220:530-4 pubmed
    ..In vivo and in vitro analyses of this interaction indicated that the unprocessed Gag polyprotein is capable of association with polymerized actin (F-actin). Binding of Gag to F-actin may be involved in the assembly or budding of HIV-1. ..
  5. Yoder A, Yu D, Dong L, Iyer S, Xu X, Kelly J, et al. HIV envelope-CXCR4 signaling activates cofilin to overcome cortical actin restriction in resting CD4 T cells. Cell. 2008;134:782-92 pubmed publisher
    ..Conversely, induction of active cofilin greatly facilitates it. These findings shed light on viral exploitation of cellular machinery in resting T cells, where chemokine receptor signaling becomes obligatory. ..
  6. Gladnikoff M, Shimoni E, Gov N, Rousso I. Retroviral assembly and budding occur through an actin-driven mechanism. Biophys J. 2009;97:2419-28 pubmed publisher
    ..The results of this study show that retroviruses utilize the cell cytoskeleton to expedite their assembly and budding. ..
  7. Spear M, Guo J, Wu Y. The trinity of the cortical actin in the initiation of HIV-1 infection. Retrovirology. 2012;9:45 pubmed publisher
    ..It is the purpose of this review to examine, in detail, the manifestation of viral dependence on the actin cytoskeleton, and present a model of how HIV utilizes actin dynamics to initiate infection. ..
  8. Olson T, Michels V, Thibodeau S, Tai Y, Keating M. Actin mutations in dilated cardiomyopathy, a heritable form of heart failure. Science. 1998;280:750-2 pubmed
    ..with hereditary idiopathic dilated cardiomyopathy (IDC) were examined for mutations in the cardiac actin gene (ACTC). Missense mutations in ACTC that cosegregate with IDC were identified in two unrelated families...
  9. Wilk T, Gowen B, Fuller S. Actin associates with the nucleocapsid domain of the human immunodeficiency virus Gag polyprotein. J Virol. 1999;73:1931-40 pubmed
    ..The same result was obtained when mature HIV-1 particles were disrupted with detergent. Taken together, these results indicate that actin molecules are associated with the NC domain of the viral polyprotein. ..

More Information

Publications149 found, 100 shown here

  1. Liu B, Dai R, Tian C, Dawson L, Gorelick R, Yu X. Interaction of the human immunodeficiency virus type 1 nucleocapsid with actin. J Virol. 1999;73:2901-8 pubmed
  2. Jolly C, Mitar I, Sattentau Q. Requirement for an intact T-cell actin and tubulin cytoskeleton for efficient assembly and spread of human immunodeficiency virus type 1. J Virol. 2007;81:5547-60 pubmed
    ..Based on these data, we propose that HIV-1 requires both actin and tubulin components of the T-cell cytoskeleton to direct its assembly and budding and to elaborate a functional VS. ..
  3. Bukrinskaya A, Brichacek B, Mann A, Stevenson M. Establishment of a functional human immunodeficiency virus type 1 (HIV-1) reverse transcription complex involves the cytoskeleton. J Exp Med. 1998;188:2113-25 pubmed
  4. Ibarrondo F, Choi R, Geng Y, Canon J, Rey O, Baldwin G, et al. HIV type 1 Gag and nucleocapsid proteins: cytoskeletal localization and effects on cell motility. AIDS Res Hum Retroviruses. 2001;17:1489-500 pubmed
    ..These data suggest that interactions between HIV-1 Gag and actin in infected cells enhance cell motility. Ultimately this enhanced motility of infected cells could promote the dissemination of virus into the brain and other tissues. ..
  5. Warrilow D, Harrich D. HIV-1 replication from after cell entry to the nuclear periphery. Curr HIV Res. 2007;5:293-9 pubmed
    ..An actin-transport process may then facilitate the remaining short journey to the nuclear membrane. ..
  6. Stolp B, Abraham L, Rudolph J, Fackler O. Lentiviral Nef proteins utilize PAK2-mediated deregulation of cofilin as a general strategy to interfere with actin remodeling. J Virol. 2010;84:3935-48 pubmed publisher
  7. Gordón Alonso M, Rocha Perugini V, Alvarez S, Moreno Gonzalo O, Ursa A, López Martín S, et al. The PDZ-adaptor protein syntenin-1 regulates HIV-1 entry. Mol Biol Cell. 2012;23:2253-63 pubmed publisher
  8. Snasel J, Pichova I. The cleavage of host cell proteins by HIV-1 protease. Folia Biol (Praha). 1996;42:227-30 pubmed
  9. Kerviel A, Thomas A, Chaloin L, Favard C, Muriaux D. Virus assembly and plasma membrane domains: which came first?. Virus Res. 2013;171:332-40 pubmed publisher
    ..This mechanism involves the trapping of acidic lipids by the viral Gag protein by means of ionic protein-lipid interactions, inducing thereby formation of acidic lipid-enriched microdomains (ALEM). ..
  10. Gil J, Krishna S. pfmdr1 (Plasmodium falciparum multidrug drug resistance gene 1): a pivotal factor in malaria resistance to artemisinin combination therapies. Expert Rev Anti Infect Ther. 2017;15:527-543 pubmed publisher
    ..Treatment failures of artemisinin therapy regimens (ACTc), the present mainstay, is emerging...
  11. Tachado S, Mayhew M, Wescott G, Foreman T, Goodwin C, McJilton M, et al. Regulation of tumor invasion and metastasis in protein kinase C epsilon-transformed NIH3T3 fibroblasts. J Cell Biochem. 2002;85:785-97 pubmed
    ..We propose that PKCepsilon directly interacts with actin to stimulate polymerization and the extension of membrane protrusions that transformed NIH3T3 cells use in vivo to penetrate and degrade surrounding tissue boundaries. ..
  12. Verboven C, Bogaerts I, Waelkens E, Rabijns A, Van Baelen H, Bouillon R, et al. Actin-DBP: the perfect structural fit?. Acta Crystallogr D Biol Crystallogr. 2003;59:263-73 pubmed
    ..It establishes DBP as the hitherto best actin-sequestering protein and highlights its key role in suppressing and preventing extracellular actin polymerization. ..
  13. Izquierdo Useros N, Esteban O, Rodriguez Plata M, Erkizia I, Prado J, Blanco J, et al. Dynamic imaging of cell-free and cell-associated viral capture in mature dendritic cells. Traffic. 2011;12:1702-13 pubmed publisher
  14. Belian E, Noseda M, Abreu Paiva M, Leja T, Sampson R, Schneider M. Forward Programming of Cardiac Stem Cells by Homogeneous Transduction with MYOCD plus TBX5. PLoS ONE. 2015;10:e0125384 pubmed publisher
    ..However, no protein was detected for the induced sarcomeric genes Actc1, Myh6, and Myl2...
  15. Liu G, Wang Y, Jiang S, Sui M, Wang C, Kang L, et al. Suppression of lymphocyte apoptosis in spleen by CXCL13 after porcine circovirus type 2 infection and regulatory mechanism of CXCL13 expression in pigs. Vet Res. 2019;50:17 pubmed publisher
    ..defense response to virus and cell-cell signaling, and another nine DEGs, KLF11, HGF, PTGES3, MAP3K11, XDH, CYCS, ACTC1, HSPH1, and RYR2, which were enriched in GO terms related to regulation of cell proliferation or apoptosis...
  16. Kondrashov A, Duc Hoang M, Smith J, Bhagwan J, Duncan G, Mosqueira D, et al. Simplified Footprint-Free Cas9/CRISPR Editing of Cardiac-Associated Genes in Human Pluripotent Stem Cells. Stem Cells Dev. 2018;27:391-404 pubmed publisher
    ..Success was shown across four cardiac-associated loci (ADRB2, GRK5, RYR2, and ACTC1) by genomic cleavage and editing efficiencies of 8%-93% and 8%-67%, respectively, including mono- and/or biallelic ..
  17. Keel B, Zarek C, Keele J, Kuehn L, Snelling W, Oliver W, et al. RNA-Seq Meta-analysis identifies genes in skeletal muscle associated with gain and intake across a multi-season study of crossbred beef steers. BMC Genomics. 2018;19:430 pubmed publisher
    ..production and oxidative stress pathways for the main effect of gain due to DEG including GPD1, NDUFA6, UQCRQ, ACTC1, and MGST3...
  18. Adams L, Tomasselli A, Robbins P, Moss B, Heinrikson R. HIV-1 protease cleaves actin during acute infection of human T-lymphocytes. AIDS Res Hum Retroviruses. 1992;8:291-5 pubmed
    ..Hydrolysis by the HIV-1 protease of physiologically important host cellular proteins during infection may have important consequences relative to viral pathogenesis. ..
  19. Solouki A, Verhoeven V, van Duijn C, Verkerk A, Ikram M, Hysi P, et al. A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14. Nat Genet. 2010;42:897-901 pubmed publisher
    ..The associated locus is near two genes that are expressed in the retina, GJD2 and ACTC1, and appears to harbor regulatory elements which may influence transcription of these genes...
  20. Takasaki A, Hirono K, Hata Y, Wang C, Takeda M, Yamashita J, et al. Sarcomere gene variants act as a genetic trigger underlying the development of left ventricular noncompaction. Pediatr Res. 2018;: pubmed publisher
    ..012), particularly variants in TPM1, TNNC1, and ACTC1 (p = 0.012)...
  21. Schiralli Lester G, Akiyama H, Evans E, Singh J, Gummuluru S, Henderson A. Interleukin 2-inducible T cell kinase (ITK) facilitates efficient egress of HIV-1 by coordinating Gag distribution and actin organization. Virology. 2013;436:235-43 pubmed publisher
    ..These data provide insight as to how ITK influences HIV-1 replication and suggest that targeting host factors that regulate HIV-1 egress provides an innovative strategy for controlling HIV infection. ..
  22. Jeong E, Vaidya B, Cho S, Park M, Kaewintajuk K, Kim S, et al. Identification of regulators of the early stage of viral hemorrhagic septicemia virus infection during curcumin treatment. Fish Shellfish Immunol. 2015;45:184-93 pubmed publisher
    ..The analysis showed that three proteins, including heat shock cognate 71 (HSC71), actin, alpha cardiac muscle (ACTC1) and elongation factor 1 (EEF1) were differentially expressed between V and CV samples...
  23. Takeuchi T, Heng H, Ye C, Liang S, Iwata J, Sonobe H, et al. Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma. Am J Pathol. 2003;163:1395-404 pubmed
    ..The present findings suggest that skeletrophin may be a novel actin-binding cytoskeleton-related molecule, expression of which is silenced in a considerable number of melanoma specimens. ..
  24. Lyonnais S, Gorelick R, Heniche Boukhalfa F, Bouaziz S, Parissi V, Mouscadet J, et al. A protein ballet around the viral genome orchestrated by HIV-1 reverse transcriptase leads to an architectural switch: from nucleocapsid-condensed RNA to Vpr-bridged DNA. Virus Res. 2013;171:287-303 pubmed publisher
  25. Frisso G, Detta N, Coppola P, Mazzaccara C, Pricolo M, D Onofrio A, et al. Functional Studies and In Silico Analyses to Evaluate Non-Coding Variants in Inherited Cardiomyopathies. Int J Mol Sci. 2016;17: pubmed
    ..506-2A>C, MYBPC3-c.906-7G>T, MYBPC3-c.2308+3G>C, SCN5A-c.393-5C>A, and ACTC1-c...
  26. Willis Owen S, Thompson A, Kemp P, Polkey M, Cookson W, Moffatt M, et al. COPD is accompanied by co-ordinated transcriptional perturbation in the quadriceps affecting the mitochondria and extracellular matrix. Sci Rep. 2018;8:12165 pubmed publisher
    ..2fold changes (SLC22A3, FAM184B, CDKN1A, FST, LINC01405, MUSK, PANX1, ANKRD1, C12orf75, MYH1, POSTN, FRZB, TNC, ACTC1, LINC00310, MYH3, MYBPH and AREG)...
  27. Bouldin A, Parisi M, Laing N, Patterson K, Gospe S. Variable presentation of nemaline myopathy: novel mutation of alpha actin gene. Muscle Nerve. 2007;35:254-8 pubmed
    ..This pair illustrates the clinical variability of nemaline myopathy, highlighting the possible influence of environmental and epigenetic factors. Implications for the current classification system and prognosis are discussed...
  28. Strozynski J, Heim J, Bunbanjerdsuk S, Wiesmann N, Zografidou L, Becker S, et al. Proteomic identification of the heterogeneous nuclear ribonucleoprotein K as irradiation responsive protein related to migration. J Proteomics. 2015;113:154-61 pubmed publisher
    ..e., GRP78, PRDX, ACTC, and the heterogeneous nuclear ribonucleoprotein K (hnRNPK), suggesting a relevant role during irradiation response...
  29. Shih Y, Zhang Y, Ding Y, Ross C, Li H, Olson T, et al. Cardiac transcriptome and dilated cardiomyopathy genes in zebrafish. Circ Cardiovasc Genet. 2015;8:261-9 pubmed publisher
    ..a single zebrafish gene for 14 of 19 multiple-homologue genes and 2 zebrafish homologues of high priority for ACTC1. Of note, our data suggested vmhc and vmhcl as functional zebrafish orthologues for human genes MYH6 and MYH7, ..
  30. Zhao Y, Cao H, Song Y, Feng Y, Ding X, Pang M, et al. Identification of novel mutations including a double mutation in patients with inherited cardiomyopathy by a targeted sequencing approach using the Ion Torrent PGM system. Int J Mol Med. 2016;37:1511-20 pubmed publisher
    ..troponin I type 3 (cardiac) (TNNI3); troponin T type 2 (cardiac) (TNNT2); actin, ?, cardiac muscle 1 (ACTC1); tropomyosin 1 (?) (TPM1); sodium channel, voltage gated, type V alpha subunit (SCN5A); myosin, light chain ..
  31. Frustaci A, De Luca A, Guida V, Biagini T, Mazza T, Gaudio C, et al. Novel α-Actin Gene Mutation p.(Ala21Val) Causing Familial Hypertrophic Cardiomyopathy, Myocardial Noncompaction, and Transmural Crypts. Clinical-Pathologic Correlation. J Am Heart Assoc. 2018;7: pubmed publisher
    Mutations of α-actin gene (ACTC1) have been phenotypically related to various cardiac anomalies, including hypertrophic cardiomyopathy and dilated cardiomyopathy and left ventricular (LV) myocardial noncompaction...
  32. Lee K, Yu P, Lingampalli N, Kim H, Tang R, Murthy N. Peptide-enhanced mRNA transfection in cultured mouse cardiac fibroblasts and direct reprogramming towards cardiomyocyte-like cells. Int J Nanomedicine. 2015;10:1841-54 pubmed publisher
    ..mouse cardiac fibroblasts via C-Lipo significantly increased expression of the cardiomyocyte marker genes, Actc1, Actn2, Gja1, Hand2, and Tnnt2, after 2 weeks of transfection...
  33. Soltysik Espanola M, Rogers R, Jiang S, Kim T, Gaedigk R, White R, et al. Characterization of Mayven, a novel actin-binding protein predominantly expressed in brain. Mol Biol Cell. 1999;10:2361-75 pubmed
    ..These results suggest that Mayven functions as an actin-binding protein that may be translocated along axonal processes and might be involved in the dynamic organization of the actin cytoskeleton in brain cells. ..
  34. Paavilainen V, Merckel M, Falck S, Ojala P, Pohl E, Wilmanns M, et al. Structural conservation between the actin monomer-binding sites of twinfilin and actin-depolymerizing factor (ADF)/cofilin. J Biol Chem. 2002;277:43089-95 pubmed
  35. Coppini R, Ho C, Ashley E, Day S, Ferrantini C, Girolami F, et al. Clinical phenotype and outcome of hypertrophic cardiomyopathy associated with thin-filament gene mutations. J Am Coll Cardiol. 2014;64:2589-2600 pubmed publisher
    ..Triphasic LV filling is particularly common in thin-filament HCM, reflecting profound diastolic dysfunction. ..
  36. Chen C, Chen C, Chern S, Wu P, Chen Y, Chen S, et al. Prenatal diagnosis and molecular cytogenetic characterization of a de novo 4.858-Mb microdeletion in 15q14 associated with ACTC1 and MEIS2 haploinsufficiency and tetralogy of Fallot. Taiwan J Obstet Gynecol. 2016;55:270-4 pubmed publisher
    ..858-Mb microdeletion in 15q14 encompassing ACTC1 and MEIS2, and metaphase FISH analysis on cultured amniocytes confirmed a 15q14 microdeletion...
  37. Yang J, Zhu M, Wang Y, Hou X, Wu H, Wang D, et al. Whole-exome sequencing identify a new mutation of MYH7 in a Chinese family with left ventricular noncompaction. Gene. 2015;558:138-42 pubmed publisher
    ..Previous reports show that defects in TAZ, SCN5A, TPM1, YWHAE, MYH7, ACTC1 and TNNT2 are associated with LVNC...
  38. Lejen T, Pene T, Rose S, Trifaro J. The role of different Scinderin domains in the control of F-actin cytoskeleton during exocytosis. Ann N Y Acad Sci. 2002;971:248-50 pubmed
    ..The results of the present study suggest the possibility that Sc might act as a molecular switch in the control of cortical F-actin dynamics during secretion. ..
  39. Wu R, Gu Y, Xu Y, Mitola S, Bussolino F, Terada L. Human immunodeficiency virus type 1 Tat regulates endothelial cell actin cytoskeletal dynamics through PAK1 activation and oxidant production. J Virol. 2004;78:779-89 pubmed
    ..We conclude that Tat induces actin cytoskeletal rearrangements through PAK1 and downstream activation of the endothelial NADPH oxidase. ..
  40. Anand A, Zhao H, Nagaraja T, Robinson L, Ganju R. N-terminal Slit2 inhibits HIV-1 replication by regulating the actin cytoskeleton. Retrovirology. 2013;10:2 pubmed publisher
    ..Our study, thus, provides insights into the role of Slit2N in HIV-1 infection and underscores its potential in limiting viral replication in T-cells...
  41. Zhao F, McParland S, Kearney F, Du L, Berry D. Detection of selection signatures in dairy and beef cattle using high-density genomic information. Genet Sel Evol. 2015;47:49 pubmed publisher
    ..e. DGAT1, ABCG2, MSTN, CAPN3, FABP3, CHCHD7, PLAG1, JAZF1, PRKG2, ACTC1, TBC1D1, GHR, BMP2, TSG1, LYN, KIT and MC1R that play a role in milk production, reproduction, body size, muscle ..
  42. Wang J, Lei B. Proteomic analysis of retinal proteins in rabbits following intravitreal PBS injection: analysis with tandem mass tag labeling coupled with LC-MS/MS. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36:595-603 pubmed
    ..Functional network analysis showed that ACTC1 and ISG15 played central roles in the protein interaction networks...
  43. Schmidt M, Chen B, Randazzo L, Bogler O. SETA/CIN85/Ruk and its binding partner AIP1 associate with diverse cytoskeletal elements, including FAKs, and modulate cell adhesion. J Cell Sci. 2003;116:2845-55 pubmed
  44. Fang F, Cui F, He Y, Yang X, Zhao X, Xu H, et al. Dextrocardia and symmetric hypertrophic cardiomyopathy with multiple mutations of genes encoding the sarcomere proteins. Int J Cardiol. 2015;187:581-4 pubmed publisher
  45. Wang L, Bai F, Zhang Q, Song W, Messer A, Kawai M. Development of apical hypertrophic cardiomyopathy with age in a transgenic mouse model carrying the cardiac actin E99K mutation. J Muscle Res Cell Motil. 2017;38:421-435 pubmed publisher
    In both humans and mice, the Glu-99-Lys (E99K) mutation in the cardiac actin gene (ACTC) results in little understood apical hypertrophic cardiomyopathy (AHCM)...
  46. Tomasselli A, Hui J, Adams L, Chosay J, Lowery D, Greenberg B, et al. Actin, troponin C, Alzheimer amyloid precursor protein and pro-interleukin 1 beta as substrates of the protease from human immunodeficiency virus. J Biol Chem. 1991;266:14548-53 pubmed
  47. Mayosi B, Khogali S, Zhang B, Watkins H. Cardiac and skeletal actin gene mutations are not a common cause of dilated cardiomyopathy. J Med Genet. 1999;36:796-7 pubmed
  48. Stamer W, Hoffman E, Luther J, Hachey D, Schey K. Protein profile of exosomes from trabecular meshwork cells. J Proteomics. 2011;74:796-804 pubmed publisher
    ..Taken together, TM exosomes have a characteristic exosome protein profile plus contain unique proteins, including the glaucoma-causing protein, myocilin; suggesting a role for exosomes in the control of intraocular pressure. ..
  49. Vikhorev P, Song W, Wilkinson R, Copeland O, Messer A, Ferenczi M, et al. The dilated cardiomyopathy-causing mutation ACTC E361G in cardiac muscle myofibrils specifically abolishes modulation of Ca(2+) regulation by phosphorylation of troponin I. Biophys J. 2014;107:2369-80 pubmed publisher
    ..Using a Ca(2+)-jump protocol, we measured the effect of the DCM-causing mutation ACTC E361G on the equilibrium and kinetic parameters of Ca(2+) regulation of contractility in single transgenic mouse ..
  50. McLeod C, Bos J, Theis J, Edwards W, Gersh B, Ommen S, et al. Histologic characterization of hypertrophic cardiomyopathy with and without myofilament mutations. Am Heart J. 2009;158:799-805 pubmed publisher
    ..6). Myofilament-positive HC does not appear to represent a distinct clinical phenotypic entity as evidenced by specific histologic characteristics and septal shape. ..
  51. Wilkinson R, Song W, Smoktunowicz N, Marston S. A dilated cardiomyopathy mutation blunts adrenergic response and induces contractile dysfunction under chronic angiotensin II stress. Am J Physiol Heart Circ Physiol. 2015;309:H1936-46 pubmed publisher
    We investigated cardiac contractility in the ACTC E361G transgenic mouse model of dilated cardiomyopathy (DCM)...
  52. Wang Y, Du X, Zhou Z, Jiang J, Zhang Z, Ye L, et al. A gain-of-function ACTC1 3'UTR mutation that introduces a miR-139-5p target site may be associated with a dominant familial atrial septal defect. Sci Rep. 2016;6:25404 pubmed publisher
    ..1784T?>?C) in the 3'-untranslated region (3'UTR) of ACTC1, which encodes the predominant actin in the embryonic heart. Further analysis demonstrated that the c...
  53. Neshati V, Mollazadeh S, Fazly Bazzaz B, de Vries A, Mojarrad M, Naderi Meshkin H, et al. Cardiomyogenic differentiation of human adipose-derived mesenchymal stem cells transduced with Tbx20-encoding lentiviral vectors. J Cell Biochem. 2018;119:6146-6153 pubmed publisher
    ..with this lentiviral vector increased the expression of the cardiomyogenic differentiation markers ACTN1, TNNI3, ACTC1, NKX2.5, TBX20 (human), and GATA4 as revealed by RT-qPCR...
  54. Pereira M, Singer R, de Meirelles M. Trypanosoma cruzi infection affects actin mRNA regulation in heart muscle cells. J Eukaryot Microbiol. 2000;47:271-9 pubmed
    ..These observations support the hypothesis that Trypanosoma cruzi affects actin mRNA regulation and localization through its effect on the cytoskeleton of heart muscle cells. ..
  55. Müller M, Mazur A, Behrmann E, Diensthuber R, Radke M, Qu Z, et al. Functional characterization of the human ?-cardiac actin mutations Y166C and M305L involved in hypertrophic cardiomyopathy. Cell Mol Life Sci. 2012;69:3457-79 pubmed publisher
    ..cardiomyopathies are caused by point mutations in sarcomeric gene products, including ?-cardiac muscle actin (ACTC1)...
  56. Gomez J, Lorca R, Reguero J, Moris C, Martin M, Tranche S, et al. Screening of the Filamin C Gene in a Large Cohort of Hypertrophic Cardiomyopathy Patients. Circ Cardiovasc Genet. 2017;10: pubmed publisher
    ..generation-sequenced (semiconductor chip technology) for the MYH7, MYBPC3, TNNT2, TNNI3, ACTC1, TNNC1, MYL2, MYL3, TPM1, and FLNC genes...
  57. Schreiber V, Moog Lutz C, Regnier C, Chenard M, Boeuf H, Vonesch J, et al. Lasp-1, a novel type of actin-binding protein accumulating in cell membrane extensions. Mol Med. 1998;4:675-87 pubmed
    ..Altogether, our results show that Lasp-1 defines a new type of actin-binding protein and suggest that the protein may play a role in a signaling pathway involved in the organization of the cytoskeleton. ..
  58. Glotov A, Kazakov S, Zhukova E, Alexandrov A, Glotov O, Pakin V, et al. Targeted next-generation sequencing (NGS) of nine candidate genes with custom AmpliSeq in patients and a cardiomyopathy risk group. Clin Chim Acta. 2015;446:132-40 pubmed publisher
    ..We developed a custom AmpliSeq panel for NGS sequencing of the coding sequences of ACTC1, MYBPC3, MYH7, MYL2, MYL3, TNNI3, TNNT2, TPM1, and CASQ2...
  59. Sung I, Son H, Ullah I, Bharti D, Park J, Cho Y, et al. Cardiomyogenic Differentiation of Human Dental Follicle-derived Stem Cells by Suberoylanilide Hydroxamic Acid and Their In Vivo Homing Property. Int J Med Sci. 2016;13:841-852 pubmed
    ..alpha-smooth muscle actin (?-SMA), cardiac muscle troponin T (TNNT2), Desmin, and cardiac muscle alpha actin (ACTC1), at both the mRNA and protein level...
  60. Wanibuchi M, Ohtaki S, Ookawa S, Kataoka Sasaki Y, Sasaki M, Oka S, et al. Actin, alpha, cardiac muscle 1 (ACTC1) knockdown inhibits the migration of glioblastoma cells in vitro. J Neurol Sci. 2018;392:117-121 pubmed publisher
    ..We recently reported that actin, alpha, cardiac muscle 1 (ACTC1) could serve as a marker to detect GBM migration in clinical cases...
  61. Khanna R, Chang S, Andrabi S, Azam M, Kim A, Rivera A, et al. Headpiece domain of dematin is required for the stability of the erythrocyte membrane. Proc Natl Acad Sci U S A. 2002;99:6637-42 pubmed
    ..Together, these results provide evidence for the physiological significance of dematin and demonstrate a role for the headpiece domain in the maintenance of structural integrity and mechanical properties of erythrocytes in vivo. ..
  62. Augière C, Mégy S, El Malti R, Boland A, el Zein L, Verrier B, et al. A Novel Alpha Cardiac Actin (ACTC1) Mutation Mapping to a Domain in Close Contact with Myosin Heavy Chain Leads to a Variety of Congenital Heart Defects, Arrhythmia and Possibly Midline Defects. PLoS ONE. 2015;10:e0127903 pubmed publisher
    ..7 meganucleotides genomic interval which included the alpha-cardiac actin gene (ACTC1) among 36 other protein coding genes. A heterozygous missense mutation was found (c.251T>C, p...
  63. Perrin Tricaud C, Davoust J, Jones I. Tagging the human immunodeficiency virus gag protein with green fluorescent protein. Minimal evidence for colocalisation with actin. Virology. 1999;255:20-5 pubmed
    ..These data suggest that Gag may associate with other cytoskeletal components or, perhaps more likely, that a partial assembly to a large-molecular-weight intermediate occurs before localisation at the plasma membrane. ..
  64. Iwasa M, Maeda K, Narita A, Maeda Y, Oda T. Dual roles of Gln137 of actin revealed by recombinant human cardiac muscle alpha-actin mutants. J Biol Chem. 2008;283:21045-53 pubmed publisher
    ..These results suggest that Gln(137) plays dual roles in actin polymerization, in both the conformational transition of the actin molecule and the mechanism of ATP hydrolysis. ..
  65. Rodríguez Serrano M, Domingo D, Igual B, Cano A, Medina P, Zorio E. Familial left ventricular noncompaction associated with a novel mutation in the alpha-cardiac actin gene. Rev Esp Cardiol (Engl Ed). 2014;67:857-9 pubmed publisher
  66. Boutilier J, Taylor R, Ram R, McNamara E, Nguyen Q, Goullee H, et al. Variable cardiac ?-actin (Actc1) expression in early adult skeletal muscle correlates with promoter methylation. Biochim Biophys Acta Gene Regul Mech. 2017;1860:1025-1036 pubmed publisher
    ..the disease phenotype of ACTA1 mouse models could be rescued by transgenic over-expression of cardiac ?-actin (ACTC1)...
  67. Hamada H, Petrino M, Kakunaga T. Molecular structure and evolutionary origin of human cardiac muscle actin gene. Proc Natl Acad Sci U S A. 1982;79:5901-5 pubmed
  68. Jung J, Bache Wiig M, Provenzano P, Ogle B. Heterogeneous Differentiation of Human Mesenchymal Stem Cells in 3D Extracellular Matrix Composites. Biores Open Access. 2016;5:37-48 pubmed publisher
    ..in ECM composites with MSCs and directly compared markers of mesodermal differentiation including cardiomyogenic (ACTC1), osteogenic (SPP1), adipogenic (PPARG), and chondrogenic (SOX9) in 2D versus 3D...
  69. Shimada H, Kato Y, Fujii H, Mori H. [Alzheimer's Therapeutic Research Institute]. Brain Nerve. 2017;69:856-861 pubmed publisher
    ..Institute on Aging (NIA) decided to commit $14 million to the ATRI via an Alzheimer's Clinical Trials Consortium (ACTC)...
  70. Cheung A, de Rooy C, Levinger I, Rana K, Clarke M, How J, et al. Actin alpha cardiac muscle 1 gene expression is upregulated in the skeletal muscle of men undergoing androgen deprivation therapy for prostate cancer. J Steroid Biochem Mol Biol. 2017;174:56-64 pubmed publisher
    ..mining identified 8 genes to be of particular interest due to known roles in androgen-mediated signalling; ABCG1, ACTC1, ANKRD1, DMPK, THY1, DCLK1, CST3 were upregulated and SLC38A3 was downregulated post-ADT...
  71. Kramer P, Luty J, Litt M. Regional localization of the gene for cardiac muscle actin (ACTC) on chromosome 15q. Genomics. 1992;13:904-5 pubmed
  72. Denard J, Rundwasser S, Laroudie N, Gonnet F, Naldini L, Radrizzani M, et al. Quantitative proteomic analysis of lentiviral vectors using 2-DE. Proteomics. 2009;9:3666-76 pubmed publisher
    ..This study defines for the first time, the protein stoichiometry of infectious HIV-1-derived LV particles. ..
  73. Girolami F, Ho C, Semsarian C, Baldi M, Will M, Baldini K, et al. Clinical features and outcome of hypertrophic cardiomyopathy associated with triple sarcomere protein gene mutations. J Am Coll Cardiol. 2010;55:1444-53 pubmed publisher
    ..essential light chains (MYL2, MYL3), troponin-T (TNNT2), troponin-I (TNNI3), alpha-tropomyosin (TPM1), and actin (ACTC). Of the 488 index patients, 4 (0...
  74. Bertrand S, Aksenova M, Mactutus C, Booze R. HIV-1 Tat protein variants: critical role for the cysteine region in synaptodendritic injury. Exp Neurol. 2013;248:228-35 pubmed publisher
    ..Preventing such early synaptic loss may attenuate HIV-1 associated neurocognitive disorders. ..
  75. Møller D, Pham T, Gustafsson F, Hedley P, Ersbøll M, Bundgaard H, et al. The role of Lamin A/C mutations in Danish patients with idiopathic dilated cardiomyopathy. Eur J Heart Fail. 2009;11:1031-5 pubmed publisher
  76. Song W, Dyer E, Stuckey D, Copeland O, Leung M, Bayliss C, et al. Molecular mechanism of the E99K mutation in cardiac actin (ACTC Gene) that causes apical hypertrophy in man and mouse. J Biol Chem. 2011;286:27582-93 pubmed publisher
    We generated a transgenic mouse model expressing the apical hypertrophic cardiomyopathy-causing mutation ACTC E99K at 50% of total heart actin and compared it with actin from patients carrying the same mutation...
  77. Pugh T, Kelly M, Gowrisankar S, Hynes E, Seidman M, Baxter S, et al. The landscape of genetic variation in dilated cardiomyopathy as surveyed by clinical DNA sequencing. Genet Med. 2014;16:601-8 pubmed publisher
    ..6 to 51%. Our data illustrate the utility of broad gene panels for genetically and clinically heterogeneous diseases but also highlight challenges as molecular diagnostics moves toward genome-wide testing. ..
  78. Zhen Y, Libotte T, Munck M, Noegel A, Korenbaum E. NUANCE, a giant protein connecting the nucleus and actin cytoskeleton. J Cell Sci. 2002;115:3207-22 pubmed
    ..The C-terminal transmembrane domain is responsible for the targeting the nuclear envelope. Thus, NUANCE is the first alpha-actinin-related protein that has the potential to link the microfilament system with the nucleus. ..
  79. Moura Lima P, Salles T, Costa F, Saad S. alpha-cardiac actin (ACTC) binds to the band 3 (AE1) cardiac isoform. J Cell Biochem. 2003;89:1215-21 pubmed
  80. Moroianu J, Riordan J. Nuclear translocation of angiogenin in proliferating endothelial cells is essential to its angiogenic activity. Proc Natl Acad Sci U S A. 1994;91:1677-81 pubmed
    ..Overall, the results suggest that nuclear translocation of angiogenin and other angiogenic molecules is a critical step in the process of angiogenesis. ..
  81. Bookwalter C, Trybus K. Functional consequences of a mutation in an expressed human alpha-cardiac actin at a site implicated in familial hypertrophic cardiomyopathy. J Biol Chem. 2006;281:16777-84 pubmed
  82. Bos J, Theis J, Tajik A, Gersh B, Ommen S, Ackerman M. Relationship between sex, shape, and substrate in hypertrophic cardiomyopathy. Am Heart J. 2008;155:1128-34 pubmed publisher
    ..Whereas mutations within the sarcomere appear to dominate the disease process, in their absence, sex has a significant modifying effect, specifically noted in cases of sigmoidal HCM. ..
  83. Wu G, Cao Y, Fan B, Zheng F, Gao X, Liu N, et al. High-mobility group protein N2 (HMGN2) inhibited the internalization of Klebsiella pneumoniae into cultured bladder epithelial cells. Acta Biochim Biophys Sin (Shanghai). 2011;43:680-7 pubmed publisher
    ..This disruption of bacterial internalization implied that HMGN2 could provide protection against K. pneumoniae infections. ..
  84. Bai F, Caster H, Dawson J, Kawai M. The immediate effect of HCM causing actin mutants E99K and A230V on actin-Tm-myosin interaction in thin-filament reconstituted myocardium. J Mol Cell Cardiol. 2015;79:123-32 pubmed publisher
    ..The effect on nH is more severe with A230V. In addition, A230V has a problem of decreased cross-bridge kinetics, which affects the normal functions of the cross-bridge cycle and may contribute to the first step of the HCM pathogenesis. ..
  85. Sadeghi A, Doyle A, Johnson B. Regulation of the cardiac L-type Ca2+ channel by the actin-binding proteins alpha-actinin and dystrophin. Am J Physiol Cell Physiol. 2002;282:C1502-11 pubmed
    ..These results suggest a combined role for dystrophin and alpha-actinin in regulating the activity of the cardiac L-type Ca2+ channel and a potential mechanism for cardiac dysfunction in Duchenne and Becker muscular dystrophies. ..
  86. Morita H, Larson M, Barr S, Vasan R, O Donnell C, Hirschhorn J, et al. Single-gene mutations and increased left ventricular wall thickness in the community: the Framingham Heart Study. Circulation. 2006;113:2697-705 pubmed
    ..Increased LVWT in the community is a very heterogeneous condition, which sometimes may arise from single-gene variants in one of a number of genes. ..
  87. Yates S, Otley M, Dawson J. Overexpression of cardiac actin with baculovirus is promoter dependent. Arch Biochem Biophys. 2007;466:58-65 pubmed
    The influence of the promoter and an N-terminal hexahistidine tag on human cardiac actin (ACTC) expression and function was investigated using four baculovirus constructs...
  88. Morita H, Rehm H, Menesses A, McDonough B, Roberts A, Kucherlapati R, et al. Shared genetic causes of cardiac hypertrophy in children and adults. N Engl J Med. 2008;358:1899-908 pubmed publisher
    ..99+/-6.12 years). We sequenced eight genes: MYH7, MYBPC3, TNNT2, TNNI3, TPM1, MYL3, MYL2, and ACTC. These genes encode sarcomere proteins that, when mutated, cause adult-onset cardiomyopathies...
  89. Rot I, Baguma Nibasheka M, Costain W, Hong P, Tafra R, Mardesic Brakus S, et al. Role of skeletal muscle in ear development. Histol Histopathol. 2017;32:987-1000 pubmed publisher
    ..allowed us to identify 6 candidate genes with a possible role in the development of the inner ear sensory organs: Actc1, Pgam2, Ldb3, Eno3, Hspb7 and Smpx...
  90. Gunning P, Ponte P, Blau H, Kedes L. alpha-skeletal and alpha-cardiac actin genes are coexpressed in adult human skeletal muscle and heart. Mol Cell Biol. 1983;3:1985-95 pubmed
  91. Patrie K, Drescher A, Welihinda A, Mundel P, Margolis B. Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, with the tight junction protein MAGI-1. J Biol Chem. 2002;277:30183-90 pubmed
    ..The interaction and colocalization of MAGI-1 with two actin-bundling proteins suggest that MAGI-1 may play a role in actin cytoskeleton dynamics within polarized epithelial cells. ..
  92. Gaidos G, Soni S, Oswald D, Toselli P, Kirsch K. Structure and function analysis of the CMS/CIN85 protein family identifies actin-bundling properties and heterotypic-complex formation. J Cell Sci. 2007;120:2366-77 pubmed