ACSL4

Summary

Gene Symbol: ACSL4
Description: acyl-CoA synthetase long chain family member 4
Alias: ACS4, FACL4, LACS4, MRX63, MRX68, long-chain-fatty-acid--CoA ligase 4, LACS 4, acyl-CoA synthetase 4, fatty-acid-Coenzyme A ligase, long-chain 4, lignoceroyl-CoA synthase, long-chain acyl-CoA synthetase 4, long-chain fatty-acid-Coenzyme A ligase 4
Species: human
Products:     ACSL4

Top Publications

  1. Maloberti P, Duarte A, Orlando U, Pasqualini M, Solano A, Lopez Otin C, et al. Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells. PLoS ONE. 2010;5:e15540 pubmed publisher
    The acyl-CoA synthetase 4 (ACSL4) is increased in breast cancer, colon and hepatocellular carcinoma...
  2. Golej D, Askari B, Kramer F, Barnhart S, Vivekanandan Giri A, Pennathur S, et al. Long-chain acyl-CoA synthetase 4 modulates prostaglandin E? release from human arterial smooth muscle cells. J Lipid Res. 2011;52:782-93 pubmed publisher
    ..Purified ACSL4 is an arachidonic acid (20:4)-preferring ACSL isoform, and ACSL4 is therefore a probable regulator of lipid ..
  3. Kantojärvi K, Kotala I, Rehnstrom K, Ylisaukko Oja T, Vanhala R, von Wendt T, et al. Fine mapping of Xq11.1-q21.33 and mutation screening of RPS6KA6, ZNF711, ACSL4, DLG3, and IL1RAPL2 for autism spectrum disorders (ASD). Autism Res. 2011;4:228-33 pubmed publisher
    ..We also analyzed ACSL4 and DLG3, which have previously been known to cause XLMR and IL1RAPL2, a homologous gene for IL1RAPL1 that is ..
  4. Orlando U, Garona J, Ripoll G, Maloberti P, Solano A, Avagnina A, et al. The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target. PLoS ONE. 2012;7:e40794 pubmed publisher
    The acyl-CoA synthetase 4 (ACSL4), which esterify mainly arachidonic acid (AA) into acyl-CoA, is increased in breast, colon and hepatocellular carcinoma...
  5. Cao Y, Dave K, Doan T, Prescott S. Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma. Cancer Res. 2001;61:8429-34 pubmed
    ..previous studies, we cloned a gene that encodes another arachidonic acid-using enzyme, fatty acid CoA ligase 4 (FACL4), and showed that overexpression of this enzyme prevents apoptosis...
  6. Meloni I, Muscettola M, Raynaud M, Longo I, Bruttini M, Moizard M, et al. FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation. Nat Genet. 2002;30:436-40 pubmed
    ..Here we report the identification of two point mutations, one missense and one splice-site change, in the gene FACL4 in two families with nonspecific mental retardation...
  7. Sung Y, Park M, Hong S, Hwang S, Kwack M, Kim J, et al. Regulation of cell growth by fatty acid-CoA ligase 4 in human hepatocellular carcinoma cells. Exp Mol Med. 2007;39:477-82 pubmed
    Fatty acid-CoA ligase 4 (FACL4) is a central enzyme controlling the unesterified free arachidonic acid (AA) level in cells and the free AA is known to induce apoptosis...
  8. Sung Y, Hwang S, Park M, Bae H, Kim W, Kim J, et al. Fatty acid-CoA ligase 4 is overexpressed in human hepatocellular carcinoma. Cancer Sci. 2003;94:421-4 pubmed
    Fatty acid-CoA ligase 4 (FACL4) is a central enzyme controlling the unesterified arachidonic acid (AA) level in cells...
  9. Liang Y, Wu C, Chu J, Wang C, Hung L, Wang Y, et al. Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase. World J Gastroenterol. 2005;11:2557-63 pubmed
    Fatty acid-CoA ligase 4 (FACL4) is an arachidonate-preferring enzyme which has been shown to be up-regulated in human colon cancer tissues and implicated in the colon tumorigenesis...

More Information

Publications90

  1. Klett E, Chen S, Edin M, Li L, Ilkayeva O, Zeldin D, et al. Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion. J Biol Chem. 2013;288:21618-29 pubmed publisher
    ..Because the predominantly expressed Acsl isoforms in INS 832/13 cells are Acsl4 and -5, we characterized the role of these Acsls in beta-cell function by using siRNA to knock down Acsl4 or Acsl5...
  2. Xu W, Yang X, Li D, Zheng K, Qiu P, Zhang W, et al. Up-regulation of fatty acid oxidation in the ligament as a contributing factor of ankylosing spondylitis: A comparative proteomic study. J Proteomics. 2015;113:57-72 pubmed publisher
    ..GO and pathway analyses showed that six fatty acid β-oxidation-related proteins (HADHB, ECHS1, ACSL4, ACADM, ACSL1 and HADH) were up-regulated in FLL cells, which was consistent with the results obtained from real-..
  3. Jia M, Meng D, Chen M, Li T, Zhang Y, Yao A. Drosophila homolog of the intellectual disability-related long-chain acyl-CoA synthetase 4 is required for neuroblast proliferation. J Genet Genomics. 2018;: pubmed publisher
    Mutations in long-chain acyl-CoA synthetase 4 (ACSL4) are associated with non-syndromic X-linked intellectual disability (ID). However, the neural functions of ACSL4 and how loss of ACSL4 leads to ID remain largely unexplored...
  4. Ferronato S, Scuro A, Fochi S, Orlandi E, Gomez Lira M, Olivato S, et al. Expression of TLR4-PTGE2 signaling genes in atherosclerotic carotid plaques and peripheral blood. Mol Biol Rep. 2018;: pubmed publisher
    ..of this study was to check the gene expression of 6 genes participating to TLR4/PTGS2 signaling (TLR4, PTGS2, ACSL4, PTGER3, PTGER4, and EPRAP) in carotid plaques and blood samples from the same individual and to evaluate these ..
  5. Jessen D, Roth C, Wiermer M, Fulda M. Two activities of long-chain acyl-coenzyme A synthetase are involved in lipid trafficking between the endoplasmic reticulum and the plastid in Arabidopsis. Plant Physiol. 2015;167:351-66 pubmed publisher
    ..The analyses of mutant lines revealed strongly overlapping functions of LACS4 and LACS9 in lipid trafficking from the endoplasmic reticulum to the plastid...
  6. Ferronato S, Scuro A, Gomez Lira M, Mazzucco S, Olivato S, Turco A, et al. Correlations between gene expression highlight a different activation of ACE/TLR4/PTGS2 signaling in symptomatic and asymptomatic plaques in atherosclerotic patients. Mol Biol Rep. 2018;: pubmed publisher
    ..Total RNA was extracted from the excised plaques and expression of PTGS2, ACE, TLR4, PTGER4, PTGER3, EPRAP and ACSL4 genes was analyzed by real-time PCR. The correlation between the pair of genes was studied by Spearman coefficient...
  7. Orlando U, Castillo A, Medrano M, Solano A, Maloberti P, Podestà E. Acyl-CoA synthetase-4 is implicated in drug resistance in breast cancer cell lines involving the regulation of energy-dependent transporter expression. Biochem Pharmacol. 2019;159:52-63 pubmed publisher
    Acyl-CoA synthetase-4 (ACSL4) is an enzyme implicated in estrogen receptor α (ERα) negative regulation and hormone therapy resistance in breast cancer...
  8. Shimshoni J, Basselin M, Li L, Coleman R, Rapoport S, Modi H. Valproate uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: relevance to valproate's efficacy against bipolar disorder. Biochim Biophys Acta. 2011;1811:163-9 pubmed publisher
    ..Rat Acsl3-, Acsl6v1- and Acsl6v2-, and Acsl4-flag proteins were expressed in E...
  9. Modi H, Basselin M, Taha A, Li L, Coleman R, Bialer M, et al. Propylisopropylacetic acid (PIA), a constitutional isomer of valproic acid, uncompetitively inhibits arachidonic acid acylation by rat acyl-CoA synthetase 4: a potential drug for bipolar disorder. Biochim Biophys Acta. 2013;1831:880-6 pubmed publisher
    ..We tested whether non-teratogenic VPA analogues might also inhibit Acsl4 catalyzed acylation, and thus have a potential anti-BD action...
  10. Dong Y, Li M, Zhang P, Wang X, Fan C, Zhou Y. Patatin-related phospholipase pPLAIIIδ influences auxin-responsive cell morphology and organ size in Arabidopsis and Brassica napus. BMC Plant Biol. 2014;14:332 pubmed publisher
    ..to ethylene, we examined the expression of the ACS and ACO genes involved in ethylene biosynthesis and found that ACS4 and ACS5 were up-regulated by 2.5-fold on average in two OE lines compared with WT plants...
  11. Dong Z, Yu Y, Li S, Wang J, Tang S, Huang R. Abscisic Acid Antagonizes Ethylene Production through the ABI4-Mediated Transcriptional Repression of ACS4 and ACS8 in Arabidopsis. Mol Plant. 2016;9:126-135 pubmed publisher
    ..Further analyses showed that expression of the ethylene biosynthesis genes ACS4, ACS8, and ACO2 was significantly decreased in abi4-152 but increased in the knockout mutants, with partial ..
  12. Brown S, Meuth A, Davis J, Rector R, Bender S. Mineralocorticoid receptor antagonism reverses diabetes-related coronary vasodilator dysfunction: A unique vascular transcriptomic signature. Pharmacol Res. 2018;134:100-108 pubmed publisher
    ..adrenergic receptors (Adra1d), cyclooxygenase-2 (Ptgs2), and modulatory factors of these pathways (Ackr3, Acsl4)...
  13. Jin Z, Yu L, Geng J, Wang J, Jin X, Huang H. A novel 47.2 Mb duplication on chromosomal bands Xq21.1-25 associated with mental retardation. Gene. 2015;567:98-102 pubmed publisher
    ..Ten genes (i.e., ZNF711, SRPX2, RAB40AL, MID2, ACSL4, PAK3, UBE2A, UPF3B, CUL4B, and GRIA3) in the duplication interval have been associated with mental retardation...
  14. Sun Q, Zhang N, Wang J, Zhang H, Li D, Shi J, et al. Melatonin promotes ripening and improves quality of tomato fruit during postharvest life. J Exp Bot. 2015;66:657-68 pubmed publisher
    ..Alteration of ethylene production correlated with altered 1-aminocyclopropane-1-carboxylic acid (ACC) synthase (ACS4) expression...
  15. Xing Y, Zhang J, Lu L, Li D, Wang Y, Huang S, et al. Identification of specific gene modules in mouse lung tissue exposed to cigarette smoke. Asian Pac J Cancer Prev. 2015;16:4251-6 pubmed
    ..Seven hub genes were identified as well, including Fip1l1, Anp32a, Acsl4, Evl, Sdc1, Arap3 and Cd52...
  16. Radif Y, Ndiaye H, Kalantzi V, Jacobs R, Hall A, Minogue S, et al. The endogenous subcellular localisations of the long chain fatty acid-activating enzymes ACSL3 and ACSL4 in sarcoma and breast cancer cells. Mol Cell Biochem. 2018;448:275-286 pubmed publisher
    ..Furthermore, enhanced expression of particular ACSL isoforms, such as ACSL4, is a feature of some more aggressive cancers and may contribute to the oncogenic phenotype...
  17. Killion E, Reeves A, El Azzouny M, Yan Q, Surujon D, Griffin J, et al. A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction. Mol Metab. 2018;9:43-56 pubmed publisher
    ..Long-chain acyl-CoA synthetase-4 (ACSL4) has been hypothesized to modulate the metabolic fates of polyunsaturated FA (PUFA), including arachidonic acid (..
  18. Bai Y, Chang R, Wang H, Xiao F, Ge R, Wang L. ENPP2 protects cardiomyocytes from erastin-induced ferroptosis. Biochem Biophys Res Commun. 2018;499:44-51 pubmed publisher
    ..Furthermore, we observed that ENPP2 overexpression regulates ferroptosis-associated gene GPX4, ACSL4 and NRF2 expression and modulates MAPK and AKT signal in H9c2 cells...
  19. Wu X, Zhi F, Lun W, Deng Q, Zhang W. Baicalin inhibits PDGF-BB-induced hepatic stellate cell proliferation, apoptosis, invasion, migration and activation via the miR-3595/ACSL4 axis. Int J Mol Med. 2018;41:1992-2002 pubmed publisher
    ..The present data also suggested that miR?3595 negatively regulates the long?chain?fatty?acid?CoA ligase 4 (ACSL4). Furthermore, ACSL4 acted in a baicalin?dependent manner to exhibit anti?fibrotic effects...
  20. Zhou L, Hussain M. Human MicroRNA-548p Decreases Hepatic Apolipoprotein B Secretion and Lipid Synthesis. Arterioscler Thromb Vasc Biol. 2017;37:786-793 pubmed publisher
    ..lipid synthesis in human hepatoma cells by reducing HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase) and ACSL4 (Acyl-CoA synthetase long-chain family member 4) enzymes involved in cholesterol and fatty acid synthesis...
  21. Ooi J, Bernardo B, Singla S, Patterson N, Lin R, McMullen J. Identification of miR-34 regulatory networks in settings of disease and antimiR-therapy: Implications for treating cardiac pathology and other diseases. RNA Biol. 2017;14:500-513 pubmed publisher
    ..Finally, we showed that Acsl4 (a common target of miR-34, let-7e and miR-31) was increased in hearts from TAC antimiR-34 treated mice...
  22. Kimura H, Arasaki K, Ohsaki Y, Fujimoto T, Ohtomo T, Yamada J, et al. Syntaxin 17 promotes lipid droplet formation by regulating the distribution of acyl-CoA synthetase 3. J Lipid Res. 2018;59:805-819 pubmed publisher
    ..Stx17 interacts with ACSL3, but not with LD formation-unrelated ACSL1 or ACSL4, through its SNARE domain...
  23. Voleman L, Najdrová V, Ástvaldsson Ã, Tůmová P, Einarsson E, Å vindrych Z, et al. Giardia intestinalis mitosomes undergo synchronized fission but not fusion and are constitutively associated with the endoplasmic reticulum. BMC Biol. 2017;15:27 pubmed publisher
    ..However, as there are currently no reports on mitochondrial fusion in the whole Excavata supergroup, it is possible that the absence of mitochondrial fusion is an ancestral trait common to all excavates. ..
  24. Ye X, Zhang Y, He B, Meng Y, Li Y, Gao Y. Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration. Int J Clin Exp Pathol. 2015;8:15836-44 pubmed
    ..05) between FOXM1 knockdown cells and control cells. Among them, three proteins ACSL4, CGGBP1 and PGRMC2 were significantly downregulated with FOXM1 reduction by western blot analysis...
  25. Banerjee S, Ghoshal S, Porter T. Activation of AMP-kinase by policosanol requires peroxisomal metabolism. Lipids. 2011;46:311-21 pubmed publisher
    ..Subsequent peroxisomal β-oxidation probably augments this effect. ..
  26. Yang X, Zheng K, Lin K, Zheng G, Zou H, Wang J, et al. Energy Metabolism Disorder as a Contributing Factor of Rheumatoid Arthritis: A Comparative Proteomic and Metabolomic Study. PLoS ONE. 2015;10:e0132695 pubmed publisher
    ..PFKP and LDHA), and the enzymes of aerobic oxidation and fatty acid oxidation were down-regulated (CS, DLST, PGD, ACSL4, ACADVL and HADHA) in RA patients...
  27. Ting N, Yaakub Z, Kamaruddin K, Mayes S, Massawe F, Sambanthamurthi R, et al. Fine-mapping and cross-validation of QTLs linked to fatty acid composition in multiple independent interspecific crosses of oil palm. BMC Genomics. 2016;17:289 pubmed publisher
    ..contains several key structural genes in the FA and oil biosynthesis pathways such as PATE/FATB, HIBCH, BASS2, LACS4 and DGAT1 and also a relevant transcription factor (TF), WRI1...
  28. Zhang J, Hu Z, Yao Q, Guo X, Nguyen V, Li F, et al. A tomato MADS-box protein, SlCMB1, regulates ethylene biosynthesis and carotenoid accumulation during fruit ripening. Sci Rep. 2018;8:3413 pubmed publisher
    ..The transcripts of ethylene biosynthesis genes (ACS2, ACS4, ACO1 and ACO3), ethylene-responsive genes (E4, E8 and ERF1) and fruit ripening-related genes (RIN, TAGL1, FUL1, ..
  29. Kagan V, Mao G, Qu F, Angeli J, Doll S, Croix C, et al. Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis. Nat Chem Biol. 2017;13:81-90 pubmed publisher
    ..Suppression of AA or AdA esterification into PE by genetic or pharmacological inhibition of acyl-CoA synthase 4 (ACSL4) acts as a specific antiferroptotic rescue pathway...
  30. Modi H, Ma K, Chang L, Chen M, Rapoport S. Valnoctamide, which reduces rat brain arachidonic acid turnover, is a potential non-teratogenic valproate substitute to treat bipolar disorder. Psychiatry Res. 2017;254:279-283 pubmed publisher
    ..VCD's ability like VPA to reduce rat brain AA turnover and inhibit recombinant Acsl-4, and its efficacy in BD, suggest that VCD be further considered as a non-teratogenic VPA substitute for treating BD. ..
  31. Doll S, Proneth B, Tyurina Y, Panzilius E, Kobayashi S, Ingold I, et al. ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition. Nat Chem Biol. 2017;13:91-98 pubmed publisher
    ..microarray analysis of ferroptosis-resistant cell lines-to uncover acyl-CoA synthetase long-chain family member 4 (ACSL4) as an essential component for ferroptosis execution...
  32. Lee A, Han S. Pinolenic Acid Downregulates Lipid Anabolic Pathway in HepG2 Cells. Lipids. 2016;51:847-55 pubmed publisher
    ..lipoprotein uptake (LDLr) and of genes that may be involved in the downregulation of the lipogenic pathway (ACSL3, ACSL4, and ACSL5) were determined by qPCR. LDLR protein levels were measured by Western blot analysis...
  33. Mourão T, Mine K, Campos E, Medina Pestana J, Tedesco Silva H, Gerbase Delima M. Predicting delayed kidney graft function with gene expression in preimplantation biopsies and first-day posttransplant blood. Hum Immunol. 2016;77:353-7 pubmed publisher
    ..biopsies (PIB) and in first-day post-Tx peripheral blood mononuclear cells (PBMC), the expression of five genes (ACSL4, CUBN, DEFB1, FABP3, GK) through real-time TaqMan PCR assays...
  34. Chen W, Wang C, Hung Y, Weng T, Yen M, Lai M. Systematic Analysis of Gene Expression Alterations and Clinical Outcomes for Long-Chain Acyl-Coenzyme A Synthetase Family in Cancer. PLoS ONE. 2016;11:e0155660 pubmed publisher
    ..ACSL3 was coexpressed with SNUPN, TRIP13, and SEMA5A in melanoma. High expression of ACSL4 predicted a worse prognosis in colorectal cancer, but predicted better prognosis in breast, brain and lung cancer...
  35. Puri P, Walker W. The regulation of male fertility by the PTPN11 tyrosine phosphatase. Semin Cell Dev Biol. 2016;59:27-34 pubmed publisher
    ..Finally, in Leydig cells, PTPN11 supports mitochondrial fusion and the expression of acyl-CoA synthetase (ACSL4) needed for the production of steroids including testosterone, which is required for fertility.
  36. Guo J, Hu Z, Zhu M, Li F, Zhu Z, Lu Y, et al. The tomato histone deacetylase SlHDA1 contributes to the repression of fruit ripening and carotenoid accumulation. Sci Rep. 2017;7:7930 pubmed publisher
    ..Ethylene content, ethylene biosynthesis genes (ACS2, ACS4 and ACO1, ACO3) and ripening-associated genes (RIN, E4, E8, Cnr, TAGL1, PG, Pti4 and LOXB) were significantly up-..
  37. Orlando U, Castillo A, Dattilo M, Solano A, Maloberti P, Podesta E. Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer. Oncotarget. 2015;6:42632-50 pubmed publisher
    Although the role of acyl-CoA synthetase 4 (ACSL4) in mediating an aggressive phenotype is well accepted, there is little evidence as to the early steps through which ACSL4 increases tumor growth and progression...
  38. Huang Y, Huang S, Lam S, Liu Z, Shui G, Zhang Y. Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids. J Cell Sci. 2016;129:4034-4045 pubmed
    ..Mutations in long-chain acyl-CoA synthetase 4 (ACSL4) are associated with non-syndromic intellectual disabilities...
  39. Seeger D, Murphy C, Murphy E. Astrocyte arachidonate and palmitate uptake and metabolism is differentially modulated by dibutyryl-cAMP treatment. Prostaglandins Leukot Essent Fatty Acids. 2016;110:16-26 pubmed publisher
    ..dBcAMP treatment increased expression of Acsl3 (4.8-fold) and Acsl4 (1...
  40. Knights K, Jones M. Inhibition kinetics of hepatic microsomal long chain fatty acid-CoA ligase by 2-arylpropionic acid non-steroidal anti-inflammatory drugs. Biochem Pharmacol. 1992;43:1465-71 pubmed
  41. Li L, Feng J, Yao H, Xie L, Chen Y, Yang L, et al. Gene expression signatures for phlegm-dampness constitution of Chinese medicine. Sci China Life Sci. 2017;60:105-107 pubmed publisher
  42. Belkaid A, Ouellette R, Surette M. 17β-estradiol-induced ACSL4 protein expression promotes an invasive phenotype in estrogen receptor positive mammary carcinoma cells. Carcinogenesis. 2017;38:402-410 pubmed publisher
    Long chain acyl-CoA synthase-4 (ACSL4) expression has been associated with an aggressive phenotype in breast carcinoma cells, whereas its role in ERα-positive breast cancer has not been studied...
  43. Wu X, Deng F, Li Y, Daniels G, Du X, Ren Q, et al. ACSL4 promotes prostate cancer growth, invasion and hormonal resistance. Oncotarget. 2015;6:44849-63 pubmed publisher
    ..examine the expression and function of the fatty acid activating enzyme, long-chain fatty acyl-CoA synthetase 4 (ACSL4), in PCa...
  44. Verot L, Alloisio N, Morlé L, Bozon M, Touraine R, Plauchu H, et al. Localization of a non-syndromic X-linked mental retardation gene (MRX80) to Xq22-q24. Am J Med Genet A. 2003;122A:37-41 pubmed
    ..This MRX localization overlaps with 7 XLMR loci (MRX23, MRX27, MRX30, MRX35, MRX47, MRX53, and MRX63)...
  45. Hecker N, Seemann S, Silahtaroglu A, Ruzzo W, Gorodkin J. Associating transcription factors and conserved RNA structures with gene regulation in the human brain. Sci Rep. 2017;7:5776 pubmed publisher
    ..We found a group of purine-uracil repeat RNA secondary structure motifs plus other motifs in neuron related genes such as ACSL4 and ERLIN2.
  46. Fujimoto Y, Itabe H, Sakai J, Makita M, Noda J, Mori M, et al. Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7. Biochim Biophys Acta. 2004;1644:47-59 pubmed
    ..These results suggest that a specific set of proteins is enriched in the lipid droplet-enriched fraction and that 17betaHSD11 localizes specifically in the fraction. ..
  47. Thomas M, Paris C, Magnien M, Colin J, Pelleïeux S, Coste F, et al. Dietary arachidonic acid increases deleterious effects of amyloid-β oligomers on learning abilities and expression of AMPA receptors: putative role of the ACSL4-cPLA2 balance. Alzheimers Res Ther. 2017;9:69 pubmed publisher
    ..Its deleterious effect on cognitive capacity could be linked to the balance between arachidonic acid-mobilizing enzymes. ..
  48. Brown C, Amante J, Goel H, Mercurio A. The ?6?4 integrin promotes resistance to ferroptosis. J Cell Biol. 2017;216:4287-4297 pubmed publisher
    ..Specifically, ?6?4-mediated activation of Src and STAT3 suppresses expression of ACSL4, an enzyme that enriches membranes with long polyunsaturated fatty acids and is required for ferroptosis...
  49. Bhat S, Schmidt K, Ladd S, Kim K, Schwartz C, Simensen R, et al. Disruption of DMD and deletion of ACSL4 causing developmental delay, hypotonia, and multiple congenital anomalies. Cytogenet Genome Res. 2006;112:170-5 pubmed
    ..associated with X-linked nonsyndromic mental retardation, acyl-CoA synthetase long chain family member 4 (ACSL4)...
  50. Guo J, Hu Z, Li F, Zhang L, Yu X, Tang B, et al. Silencing of histone deacetylase SlHDT3 delays fruit ripening and suppresses carotenoid accumulation in tomato. Plant Sci. 2017;265:29-38 pubmed publisher
    ..Ethylene content was also reduced and expression of ethylene biosynthetic genes (ACS2, ACS4 and ACO1, ACO3) and ripening-associated genes (RIN, E4, E8, PG, Pti4 and LOXB) was significantly down-regulated in ..
  51. Hu C, Chen L, Jiang Y, Li Y, Wang S. The effect of fatty acid-CoA ligase 4 on the growth of hepatic cancer cells. Cancer Biol Ther. 2008;7:131-4 pubmed
    In this study, we detected the expression of FACL4 mRNA in 40 patients with hepatic carcinoma and its adjacent normal tissues by semi-quantitative RT-PCR...
  52. Zeman M, Vecka M, Jachymova M, Jirak R, Tvrzicka E, Stankova B, et al. Fatty acid CoA ligase-4 gene polymorphism influences fatty acid metabolism in metabolic syndrome, but not in depression. Tohoku J Exp Med. 2009;217:287-93 pubmed
    ..Within the cell, fatty acid coenzyme A (CoA) ligases (FACLs) activate PUFAs by esterifying with CoA. The FACL4 isoform prefers PUFAs (arachidonic and eicosapentaenoic acid) as substrates, and the FACL4 gene is mapped to Xq23...
  53. Knights K, Gasser R, Klemisch W. In vitro metabolism of acitretin by human liver microsomes: evidence of an acitretinoyl-coenzyme A thioester conjugate in the transesterification to etretinate. Biochem Pharmacol. 2000;60:507-16 pubmed
    ..Predicting clearance of acitretin in vivo via this unique metabolic pathway will be a challenge, as the intracellular concentration of ethanol could never be predicted with any degree of accuracy in humans. ..
  54. Müller T, Dewitz C, Schmitz J, Schröder A, Bräsen J, Stockwell B, et al. Necroptosis and ferroptosis are alternative cell death pathways that operate in acute kidney failure. Cell Mol Life Sci. 2017;74:3631-3645 pubmed publisher
    ..examined the contribution of the key fatty acid metabolism enzyme, acyl-CoA synthetase long-chain family member 4 (ACSL4), in regulating ferroptosis...
  55. Milewska M, McRedmond J, Byrne P. Identification of novel spartin-interactors shows spartin is a multifunctional protein. J Neurochem. 2009;111:1022-30 pubmed publisher
    ..We also show for the first time interaction between spartin and a nucleolar protein, nucleolin. ..
  56. Yen M, Kan J, Hsieh C, Kuo P, Hou M, Hsu Y. Association of long-chain acyl-coenzyme A synthetase 5 expression in human breast cancer by estrogen receptor status and its clinical significance. Oncol Rep. 2017;37:3253-3260 pubmed publisher
    ..Five ACSL isoforms including ACSL1, ACSL3, ACSL4, ACSL5 and ACSL6 are identified in human...
  57. Li Z, Jiang H, Xie W, Zhang Z, Smrcka A, Wu D. Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction. Science. 2000;287:1046-9 pubmed
    ..The PLC pathways also appear to inhibit the chemotactic activity induced by certain chemoattractants and to suppress TI-IglambdaL production. ..
  58. Jonsson J, Renieri A, Gallagher P, Kashtan C, Cherniske E, Bruttini M, et al. Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis: a new X linked contiguous gene deletion syndrome?. J Med Genet. 1998;35:273-8 pubmed
  59. Zhang Y, Chen D, Wang Z. Analyses of mental dysfunction-related ACSl4 in Drosophila reveal its requirement for Dpp/BMP production and visual wiring in the brain. Hum Mol Genet. 2009;18:3894-905 pubmed publisher
    ..Mutations in ACSL4 are associated with non-syndromic X-linked mental retardation (MRX)...
  60. Cooke M, Orlando U, Maloberti P, Podesta E, Cornejo Maciel F. Tyrosine phosphatase SHP2 regulates the expression of acyl-CoA synthetase ACSL4. J Lipid Res. 2011;52:1936-48 pubmed publisher
    Acyl-CoA synthetase 4 (ACSL4) is implicated in fatty acid metabolism with marked preference for arachidonic acid (AA)...
  61. An C, Zhang K, Gao X, Zheng Z, Shi Z, Gong P, et al. No association between polymorphisms in the FACL4 (fatty acid-CoA ligase 4) gene and nonspecific mental retardation in Qin-Ba mountain region of China. Neurosci Lett. 2008;441:197-200 pubmed publisher
    ..b>FACL4 gene mutations in three Italian MR pedigrees have been reported as causing non-specific mental retardation...
  62. Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, et al. Autophagosomes form at ER-mitochondria contact sites. Nature. 2013;495:389-93 pubmed publisher
    ..These results provide new insight into organelle biogenesis by demonstrating that the ER-mitochondria contact site is important in autophagosome formation...
  63. Wu X, Li Y, Wang J, Wen X, Marcus M, Daniels G, et al. Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer. PLoS ONE. 2013;8:e77060 pubmed publisher
    The purpose of this study was to determine the role of long-chain fatty acyl-CoA synthetase 4 (ACSL4) in breast cancer...
  64. Küch E, Vellaramkalayil R, Zhang I, Lehnen D, Brugger B, Sreemmel W, et al. Differentially localized acyl-CoA synthetase 4 isoenzymes mediate the metabolic channeling of fatty acids towards phosphatidylinositol. Biochim Biophys Acta. 2014;1841:227-39 pubmed
    The acyl-CoA synthetase 4 (ACSL4) has been implicated in carcinogenesis and neuronal development. Acyl-CoA synthetases are essential enzymes of lipid metabolism, and ACSL4 is distinguished by its preference for arachidonic acid...
  65. Cui M, Xiao Z, Sun B, Wang Y, Zheng M, Ye L, et al. Involvement of cholesterol in hepatitis B virus X protein-induced abnormal lipid metabolism of hepatoma cells via up-regulating miR-205-targeted ACSL4. Biochem Biophys Res Commun. 2014;445:651-5 pubmed publisher
    ..Interestingly, we showed that the expression levels of acyl-CoA synthetase long-chain family member 4 (ACSL4) were negatively associated with those of miR-205 in clinical HCC tissues...
  66. Ansari I, Longacre M, Stoker S, Kendrick M, O Neill L, Zitur L, et al. Characterization of Acyl-CoA synthetase isoforms in pancreatic beta cells: Gene silencing shows participation of ACSL3 and ACSL4 in insulin secretion. Arch Biochem Biophys. 2017;618:32-43 pubmed publisher
    ..b>ACSL4 and ACSL3 proteins were present in the beta cells and human and rat pancreatic islets and concentrated in insulin ..
  67. Mashek D, Bornfeldt K, Coleman R, Berger J, Bernlohr D, Black P, et al. Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family. J Lipid Res. 2004;45:1958-61 pubmed
    ..Splice variants of ACSL3, -4, -5, and -6 are cataloged. Suggestions for naming other family members and for the nonmammalian acyl-CoA synthetases are made. ..
  68. Zhang C, Li A, Zhang X, Xiao H. A novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation. J Biol Chem. 2011;286:9373-81 pubmed publisher
    ..describe a protein complex consisting of TIP30, endophilin B1, and acyl-CoA synthetase long chain family member 4 (ACSL4) that interacts with Rab5a and regulates EGFR endocytosis and signaling...
  69. Covault J, Pettinati H, Moak D, Mueller T, Kranzler H. Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema. Am J Med Genet B Neuropsychiatr Genet. 2004;127B:42-7 pubmed
    ..Long-chain fatty acid-CoA ligase type 4 (FACL4; MIM 300157) is a key enzyme involved in the metabolism of AA, EPA, and DHA...
  70. Kan C, Singh A, Dong B, Shende V, Liu J. PPARδ activation induces hepatic long-chain acyl-CoA synthetase 4 expression in vivo and in vitro. Biochim Biophys Acta. 2015;1851:577-87 pubmed publisher
    The arachidonic acid preferred long-chain acyl-CoA synthetase 4 (ACSL4) is a key enzyme for fatty acid metabolism in various metabolic tissues...
  71. Kuwata H, Hara S. Inhibition of long-chain acyl-CoA synthetase 4 facilitates production of 5, 11-dihydroxyeicosatetraenoic acid via the cyclooxygenase-2 pathway. Biochem Biophys Res Commun. 2015;465:528-33 pubmed publisher
    ..Among ACSL enzymes, ACSL4 prefers arachidonic acid (AA) as a substrate and plays an important role in re-esterification of free AA...
  72. Ye X, Zhang Y, Wang X, Li Y, Gao Y. Tumor-suppressive functions of long-chain acyl-CoA synthetase 4 in gastric cancer. IUBMB Life. 2016;68:320-7 pubmed publisher
    b>Long chain acyl CoA synthetase 4 (ACSL4) is a key enzyme in fatty acid metabolism with marked preference for arachidonic acid (AA). Recent reports have implicated its crucial roles in tumorigenesis...
  73. Kan C, Singh A, Stafforini D, Azhar S, Liu J. Arachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation. J Lipid Res. 2014;55:1657-67 pubmed publisher
    b>ACSL4 is a member of the long-chain acyl-CoA synthetase (ACSL) family with a marked preference for arachidonic acid (AA) as its substrate...
  74. Zhang K, Zheng Z, An C, Gao X, Zhang F. Genetic variations of FACL4 have no obvious influence on cognitive ability in young Chinese children. Psychiatry Res. 2010;178:202-4 pubmed publisher
    The influence of genetic variants of FACL4 on individual cognitive ability was examined in a random sample of 213 boys and 224 girls. Both conventional genetic methods and analysis of variance were applied in this study...
  75. Cao Y, Traer E, Zimmerman G, McIntyre T, Prescott S. Cloning, expression, and chromosomal localization of human long-chain fatty acid-CoA ligase 4 (FACL4). Genomics. 1998;49:327-30 pubmed
    ..Finally, this gene was localized to chromosome Xq23 in human by FISH analysis. ..
  76. Piccini M, Vitelli F, Bruttini M, Pober B, Jonsson J, Villanova M, et al. FACL4, a new gene encoding long-chain acyl-CoA synthetase 4, is deleted in a family with Alport syndrome, elliptocytosis, and mental retardation. Genomics. 1998;47:350-8 pubmed
    ..contributing to this complex phenotype, we have isolated a gene encoding a new long-chain acyl-CoA synthetase (FACL4 or LACS4) from the region deleted in these patients...
  77. Guo J, Hu Z, Yu X, Li A, Li F, Wang Y, et al. A histone deacetylase gene, SlHDA3, acts as a negative regulator of fruit ripening and carotenoid accumulation. Plant Cell Rep. 2018;37:125-135 pubmed publisher
    ..production also stimulated along with significantly up-regulated expression of ethylene biosynthetic genes (ACS2, ACS4, ACO1 and ACO3) and fruit ripening-associated genes (RIN, E4, E8, PG, Pti4, LOXB, Cnr and TAGL1) in SlHDA3 RNAi ..
  78. Sánchez Martínez R, Cruz Gil S, García Álvarez M, Reglero G, Ramirez de Molina A. Complementary ACSL isoforms contribute to a non-Warburg advantageous energetic status characterizing invasive colon cancer cells. Sci Rep. 2017;7:11143 pubmed publisher
    ..of acyl coA synthetases (ACSL) isoforms to the previously described ACSL/stearoyl-CoA desaturase (ACSL1/ACSL4/SCD) metabolic network causing invasion and poor prognosis in colorectal cancer (CRC)...
  79. Tuohetahuntila M, Spee B, Kruitwagen H, Wubbolts R, Brouwers J, van de Lest C, et al. Role of long-chain acyl-CoA synthetase 4 in formation of polyunsaturated lipid species in hepatic stellate cells. Biochim Biophys Acta. 2015;1851:220-30 pubmed publisher
    ..Inhibition of the activity of ACSL4 by siRNA-mediated knockdown or addition of rosiglitazone specifically inhibited the incorporation of deuterated ..
  80. Longo I, Frints S, Fryns J, Meloni I, Pescucci C, Ariani F, et al. A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients. J Med Genet. 2003;40:11-7 pubmed
    The gene encoding fatty acid CoA ligase 4 (FACL4) is mutated in families with non-specific X linked mental retardation (MRX) and is responsible for cognitive impairment in the contiguous gene syndrome ATS-MR (Alport syndrome and mental ..
  81. Yuan H, Li X, Zhang X, Kang R, Tang D. Identification of ACSL4 as a biomarker and contributor of ferroptosis. Biochem Biophys Res Commun. 2016;478:1338-43 pubmed publisher
    ..Here, we show that acyl-CoA synthetase long-chain family member 4 (ACSL4) is required for ferroptotic cancer cell death. Compared with ferroptosis-sensitive cells (e.g...