ACSL4

Summary

Gene Symbol: ACSL4
Description: acyl-CoA synthetase long-chain family member 4
Alias: ACS4, FACL4, LACS4, MRX63, MRX68, long-chain-fatty-acid--CoA ligase 4, LACS 4, acyl-CoA synthetase 4, fatty-acid-Coenzyme A ligase, long-chain 4, lignoceroyl-CoA synthase, long-chain acyl-CoA synthetase 4, long-chain fatty-acid-Coenzyme A ligase 4
Species: human

Top Publications

  1. ncbi Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma
    Y Cao
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Cancer Res 61:8429-34. 2001
  2. ncbi FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation
    Ilaria Meloni
    Medical Genetics, Department of Molecular Biology, University of Siena, Italy
    Nat Genet 30:436-40. 2002
  3. ncbi Fatty acid-CoA ligase 4 is overexpressed in human hepatocellular carcinoma
    Young Kwan Sung
    Department of Immunology, Kyungpook National University Medical School and Hospital, Daegu, 700 422, Korea
    Cancer Sci 94:421-4. 2003
  4. pmc Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase
    Yu Chih Liang
    School of Medical Technology, Taipei Medical University, Taipei, Taiwan, China
    World J Gastroenterol 11:2557-63. 2005
  5. ncbi Regulation of cell growth by fatty acid-CoA ligase 4 in human hepatocellular carcinoma cells
    Young Kwan Sung
    Department of Immunology, School of Medicine, Kyungpook National University, Daegu 700 422, Korea
    Exp Mol Med 39:477-82. 2007
  6. pmc Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells
    Paula M Maloberti
    Instituto de Investigaciones Moleculares de Enfermedades Hormonales Neurodegenerativas y Oncológicas, Department of Human Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    PLoS ONE 5:e15540. 2010
  7. pmc Long-chain acyl-CoA synthetase 4 modulates prostaglandin E₂ release from human arterial smooth muscle cells
    Deidre L Golej
    Department of Pathology, Diabetes and Obesity Center of Excellence, University of Washington School of Medicine, Seattle, WA 98109, USA
    J Lipid Res 52:782-93. 2011
  8. doi Fine mapping of Xq11.1-q21.33 and mutation screening of RPS6KA6, ZNF711, ACSL4, DLG3, and IL1RAPL2 for autism spectrum disorders (ASD)
    Katri Kantojärvi
    Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland
    Autism Res 4:228-33. 2011
  9. pmc The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target
    Ulises D Orlando
    Instituto de Investigaciones Biomedicas, Department of Human Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    PLoS ONE 7:e40794. 2012
  10. doi Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells
    G M Johnsen
    Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway
    Placenta 30:1037-44. 2009

Research Grants

  1. ROSALIND ANNE COLEMAN; Fiscal Year: 2015
  2. Eric Klett; Fiscal Year: 2014
  3. Jingwen Liu; Fiscal Year: 2015
  4. Reprogramming of X-linked genes by nuclear transfer
    X Tian; Fiscal Year: 2003
  5. Brain Uptake and Utilization of Fatty Acids and Lipids
    Paul Watkins; Fiscal Year: 2004
  6. XALD: Role of Very Long Chain Fatty Acyl-CoA Synthetases
    Paul Watkins; Fiscal Year: 2006

Scientific Experts

Detail Information

Publications138 found, 100 shown here

  1. ncbi Fatty acid CoA ligase 4 is up-regulated in colon adenocarcinoma
    Y Cao
    Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA
    Cancer Res 61:8429-34. 2001
    ..previous studies, we cloned a gene that encodes another arachidonic acid-using enzyme, fatty acid CoA ligase 4 (FACL4), and showed that overexpression of this enzyme prevents apoptosis...
  2. ncbi FACL4, encoding fatty acid-CoA ligase 4, is mutated in nonspecific X-linked mental retardation
    Ilaria Meloni
    Medical Genetics, Department of Molecular Biology, University of Siena, Italy
    Nat Genet 30:436-40. 2002
    ..Here we report the identification of two point mutations, one missense and one splice-site change, in the gene FACL4 in two families with nonspecific mental retardation...
  3. ncbi Fatty acid-CoA ligase 4 is overexpressed in human hepatocellular carcinoma
    Young Kwan Sung
    Department of Immunology, Kyungpook National University Medical School and Hospital, Daegu, 700 422, Korea
    Cancer Sci 94:421-4. 2003
    Fatty acid-CoA ligase 4 (FACL4) is a central enzyme controlling the unesterified arachidonic acid (AA) level in cells...
  4. pmc Involvement of fatty acid-CoA ligase 4 in hepatocellular carcinoma growth: roles of cyclic AMP and p38 mitogen-activated protein kinase
    Yu Chih Liang
    School of Medical Technology, Taipei Medical University, Taipei, Taiwan, China
    World J Gastroenterol 11:2557-63. 2005
    Fatty acid-CoA ligase 4 (FACL4) is an arachidonate-preferring enzyme which has been shown to be up-regulated in human colon cancer tissues and implicated in the colon tumorigenesis...
  5. ncbi Regulation of cell growth by fatty acid-CoA ligase 4 in human hepatocellular carcinoma cells
    Young Kwan Sung
    Department of Immunology, School of Medicine, Kyungpook National University, Daegu 700 422, Korea
    Exp Mol Med 39:477-82. 2007
    Fatty acid-CoA ligase 4 (FACL4) is a central enzyme controlling the unesterified free arachidonic acid (AA) level in cells and the free AA is known to induce apoptosis...
  6. pmc Functional interaction between acyl-CoA synthetase 4, lipooxygenases and cyclooxygenase-2 in the aggressive phenotype of breast cancer cells
    Paula M Maloberti
    Instituto de Investigaciones Moleculares de Enfermedades Hormonales Neurodegenerativas y Oncológicas, Department of Human Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    PLoS ONE 5:e15540. 2010
    The acyl-CoA synthetase 4 (ACSL4) is increased in breast cancer, colon and hepatocellular carcinoma...
  7. pmc Long-chain acyl-CoA synthetase 4 modulates prostaglandin E₂ release from human arterial smooth muscle cells
    Deidre L Golej
    Department of Pathology, Diabetes and Obesity Center of Excellence, University of Washington School of Medicine, Seattle, WA 98109, USA
    J Lipid Res 52:782-93. 2011
    ..Purified ACSL4 is an arachidonic acid (20:4)-preferring ACSL isoform, and ACSL4 is therefore a probable regulator of lipid ..
  8. doi Fine mapping of Xq11.1-q21.33 and mutation screening of RPS6KA6, ZNF711, ACSL4, DLG3, and IL1RAPL2 for autism spectrum disorders (ASD)
    Katri Kantojärvi
    Department of Medical Genetics, Haartman Institute, University of Helsinki, Helsinki, Finland
    Autism Res 4:228-33. 2011
    ..We also analyzed ACSL4 and DLG3, which have previously been known to cause XLMR and IL1RAPL2, a homologous gene for IL1RAPL1 that is ..
  9. pmc The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target
    Ulises D Orlando
    Instituto de Investigaciones Biomedicas, Department of Human Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina
    PLoS ONE 7:e40794. 2012
    The acyl-CoA synthetase 4 (ACSL4), which esterify mainly arachidonic acid (AA) into acyl-CoA, is increased in breast, colon and hepatocellular carcinoma...
  10. doi Long-chain polyunsaturated fatty acids stimulate cellular fatty acid uptake in human placental choriocarcinoma (BeWo) cells
    G M Johnsen
    Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway
    Placenta 30:1037-44. 2009
    ..LCPUFAs and OA increased the gene expression of ADRP whilst decreased the expression of ASCL3, ACSL4, ACSL6, LPIN1, and FABP3 in these cells. However, LCPUFAs but not OA increased expression of ACSL1 and ACSL5...
  11. pmc Mutagenesis of rat acyl-CoA synthetase 4 indicates amino acids that contribute to fatty acid binding
    Lori Stinnett
    Department of Nutrition, 2301 Michael Hooker Research Center, Pittsboro St, University of North Carolina, Chapel Hill, NC 27599, USA
    Biochim Biophys Acta 1771:119-25. 2007
    ..acyl-CoA synthetases (ACSL) can bind saturated and unsaturated fatty acids ranging from 12 to 22 carbons, ACSL4 prefers longer chain polyunsaturated fatty acids...
  12. pmc Expression of Long-chain Fatty Acyl-CoA Synthetase 4 in Breast and Prostate Cancers Is Associated with Sex Steroid Hormone Receptor Negativity
    Marie E Monaco
    Department of Physiology and Neuroscience, NYU School of Medicine, New York, NY, USA
    Transl Oncol 3:91-8. 2010
    ..Our results indicate that the fatty acid-activating enzyme, long-chain fatty acyl-CoA synthetase 4 (ACSL4), is differentially expressed in human breast cancer as a function of estrogen receptor alpha (ER) status...
  13. ncbi RFLP analysis of 1-aminocyclopropane-1-carboxylate synthase ACC2 and ACC4 genes from Polish cultivars of tomato
    Małgorzata Jakubowicz
    Institute of Molecular Biology and Biotechnology, Adam Mickiewicz University, Miedzychodzka 5, 60 371 Poznan, Poland
    Acta Biochim Pol 49:1037-42. 2002
    ..ethylene synthesis in tomato is controlled mainly by 1-aminocyclopropane-1-carboxylate synthase LE-ACS2 and LE-ACS4 isoenzymes (Rottmann et al., 1991, J. Mol. Biol. 222: 937; Lincoln et al., 1993, J. Biol. Chem...
  14. doi Down-regulation in muscle and liver lipogenic genes: EPA ethyl ester treatment in lean and overweight (high-fat-fed) rats
    Nerea Pérez-Echarri
    Department of Nutrition and Food Sciences, Physiology and Toxicology, University of Navarra, Pamplona, Spain
    J Nutr Biochem 20:705-14. 2009
    ..On the other hand, no alterations in genes involved in beta-oxidation, such acetyl CoA synthase 4 (ACS4), acetyl CoA synthase 5 (ACS5) or acetyl CoA oxidase (ACO), were found in EPA-treated groups...
  15. ncbi Localization of human X chromosomal mental retardation (MRX) genes in chicken and comparison with the chicken genome sequence data
    M Kohn
    Department of Human Genetics, University Ulm, Ulm, Germany
    Cytogenet Genome Res 108:342-7. 2005
    ..TM4SF2, RSK2/RPS6KA3, NLGN4, ARX) map to GGA1q13-->q31, and seven genes from HSAXq (OPHN1, AGTR2, ARHGEF6, PAK3, FACL4/ACS4, FMR2, ATRX) to GGA4p. The gene-rich region of HSAXq28 proved to be much less conserved...
  16. ncbi Silencing the expression of mitochondrial acyl-CoA thioesterase I and acyl-CoA synthetase 4 inhibits hormone-induced steroidogenesis
    Paula Maloberti
    Department of Biochemistry, School of Medicine, University of Buenos Aires, Argentina
    FEBS J 272:1804-14. 2005
    ..MTE-I) by antisense or small interfering RNA (siRNA) and of the arachidonic acid-preferring acyl-CoA synthetase (ACS4) by siRNA produced a marked reduction in steroid output of cAMP-stimulated Leydig cells...
  17. ncbi [Non-specific X-linked mental retardation]
    F Martínez-Castellano
    Hospital Universitario La Fe, 46009 Valencia, Espana
    Rev Neurol 42:S77-83. 2006
    ..Genetic linkage studies showed it to have a high rate of genetic heterogeneity...
  18. ncbi Protein tyrosine phosphatases regulate arachidonic acid release, StAR induction and steroidogenesis acting on a hormone-dependent arachidonic acid-preferring acyl-CoA synthetase
    Florencia Cano
    Department of Biochemistry, School of Medicine, University of Buenos Aires, Paraguay 2155, 5th, Buenos Aires C1121ABG, Argentina
    J Steroid Biochem Mol Biol 99:197-202. 2006
    ..mediated by protein tyrosine phosphatases (PTPs) and the release of arachidonic acid (AA) mediated by two enzymes, ACS4 (acyl-CoA synthetase 4) and Acot2 (mitochondrial thioesterase)...
  19. pmc Rosiglitazone inhibits acyl-CoA synthetase activity and fatty acid partitioning to diacylglycerol and triacylglycerol via a peroxisome proliferator-activated receptor-gamma-independent mechanism in human arterial smooth muscle cells and macrophages
    Bardia Askari
    Department of Pathology, 1959 NE Pacific St, University of Washington School of Medicine, Seattle, WA 98195 7470, USA
    Diabetes 56:1143-52. 2007
    ..Because it is unknown if ACSL4 is expressed in vascular cells involved in atherosclerosis, we investigated the ability of rosiglitazone to ..
  20. pmc Expression of ethylene biosynthetic and receptor genes in rose floral tissues during ethylene-enhanced flower opening
    Jingqi Xue
    Department of Ornamental Horticulture, China Agricultural University, Beijing 100094, China
    J Exp Bot 59:2161-9. 2008
    ..The expression of Rh-ACS2 and Rh-ACS3 was quickly induced by ethylene in gynoecia, but neither Rh-ACS1 nor Rh-ACS4 was induced by ethylene in any of the five tissues...
  21. pmc Association between fatty acid compositions and genotypes of FABP4 and LXR-alpha in Japanese black cattle
    Shogo Hoashi
    Laboratory of Animal Breeding and Genetics, Graduate School of Agricultural Science, Kobe University, Nada, Kobe, Japan
    BMC Genet 9:84. 2008
    ..genes, adipocytes-type fatty acid binding protein (FABP4), liver X receptor alpha (LXRalpha), cytochrome b5 (Cyt b5), long-chain acyl-CoA synthetase (ACSL) 1, ACSL4 and diacylglycerol acyltransferase 2 (DGAT2) and fatty acid composition.
  22. doi Intellectual disability, midface hypoplasia, facial hypotonia, and Alport syndrome are associated with a deletion in Xq22.3
    Jayson D Rodriguez
    JC Self Research Institute of Human Genetics, Greenwood Genetic Center, Greenwood, South Carolina, USA
    Am J Med Genet A 152:713-7. 2010
    ..3 including COL4A5 and ACSL4. We report on a family with two males with this disorder and a Xq22.3 deletion...
  23. doi Genetic variations of FACL4 have no obvious influence on cognitive ability in young Chinese children
    Kejin Zhang
    Key Laboratory of Resource Biology and Biotechnology in Western China Northwest University, Ministry of Education, College of Life Science, Institute of Population and Health, Northwest, University, Xi an, China
    Psychiatry Res 178:202-4. 2010
    The influence of genetic variants of FACL4 on individual cognitive ability was examined in a random sample of 213 boys and 224 girls. Both conventional genetic methods and analysis of variance were applied in this study...
  24. doi Combined activity of LACS1 and LACS4 is required for proper pollen coat formation in Arabidopsis
    Dirk Jessen
    Albrecht von Haller Institute for Plant Sciences, Department of Plant Biochemistry, Georg August University, Goettingen, Germany
    Plant J 68:715-26. 2011
    ..Here, we report on the identification of lacs1 lacs4 double knock-out mutant lines that were conditionally sterile and showed significant reductions in pollen coat ..
  25. doi Long-chain acyl-CoA synthetase 4 is regulated by phosphorylation
    María Emilia Smith
    Department of Biochemistry, School of Medicine, University of Buenos Aires, CONICET, Buenos Aires, Argentina
    Biochem Biophys Res Commun 430:272-7. 2013
    b>Long chain acyl CoA synthetase 4 (Acsl4) is a key enzyme in steroidogenesis. It participates in steroid synthesis through of arachidonic acid release and Steroidogenic Acute Regulatory protein (StAR) induction...
  26. doi Autophagosomes form at ER-mitochondria contact sites
    Maho Hamasaki
    Department of Genetics, Graduate School of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Nature 495:389-93. 2013
    ..These results provide new insight into organelle biogenesis by demonstrating that the ER-mitochondria contact site is important in autophagosome formation...
  27. pmc Melatonin promotes ripening and improves quality of tomato fruit during postharvest life
    Qianqian Sun
    College of Agriculture and Biotechnology, China Agricultural University, Beijing, China
    J Exp Bot 66:657-68. 2015
    ..Alteration of ethylene production correlated with altered 1-aminocyclopropane-1-carboxylic acid (ACC) synthase (ACS4) expression...
  28. pmc Global Transcriptomic Profiling of Cardiac Hypertrophy and Fatty Heart Induced by Long-Term High-Energy Diet in Bama Miniature Pigs
    Jihan Xia
    State Key Laboratory of Animal Nutrition, Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, P R China
    PLoS ONE 10:e0132420. 2015
    ..RT-PCR assays identified several important differentially expressed heart-related genes, including STAT3, ACSL4, ATF4, FADD, PPP3CA, CD74, SLA-8, VCL, ACTN2 and FGFR1, which may be targets of further research...
  29. doi Inhibition of long-chain acyl-CoA synthetase 4 facilitates production of 5, 11-dihydroxyeicosatetraenoic acid via the cyclooxygenase-2 pathway
    Hiroshi Kuwata
    Division of Health Chemistry, Department of Healthcare and Regulatory Sciences, School of Pharmacy, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan Electronic address
    Biochem Biophys Res Commun 465:528-33. 2015
    ..Among ACSL enzymes, ACSL4 prefers arachidonic acid (AA) as a substrate and plays an important role in re-esterification of free AA...
  30. doi Abscisic Acid Antagonizes Ethylene Production through the ABI4-Mediated Transcriptional Repression of ACS4 and ACS8 in Arabidopsis
    Zhijun Dong
    College of Biological Sciences, China Agricultural University, Beijing 100193, China Plant Molecular Biology Department, Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing 100081, China National Key Facility of Crop Gene Resources and Genetic Improvement, Beijing 100081, China
    Mol Plant 9:126-35. 2016
    ..Further analyses showed that expression of the ethylene biosynthesis genes ACS4, ACS8, and ACO2 was significantly decreased in abi4-152 but increased in the knockout mutants, with partial ..
  31. doi The regulation of male fertility by the PTPN11 tyrosine phosphatase
    Pawan Puri
    Center for Research in Reproductive Physiology, Department of Obstetrics, Gynecology and Reproductive Sciences, Magee Womens Research Institute, University of Pittsburgh, Pittsburgh, PA 15261, United States Electronic address
    Semin Cell Dev Biol 59:27-34. 2016
    ..Finally, in Leydig cells, PTPN11 supports mitochondrial fusion and the expression of acyl-CoA synthetase (ACSL4) needed for the production of steroids including testosterone, which is required for fertility.
  32. doi Tumor-suppressive functions of long-chain acyl-CoA synthetase 4 in gastric cancer
    Xiaojuan Ye
    Department of Oncology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China
    IUBMB Life 68:320-7. 2016
    b>Long chain acyl CoA synthetase 4 (ACSL4) is a key enzyme in fatty acid metabolism with marked preference for arachidonic acid (AA). Recent reports have implicated its crucial roles in tumorigenesis...
  33. ncbi Acsl, the Drosophila ortholog of intellectual-disability-related ACSL4, inhibits synaptic growth by altered lipids
    Yan Huang
    State Key Laboratory for Molecular and Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Cell Sci 129:4034-4045. 2016
    ..Mutations in long-chain acyl-CoA synthetase 4 (ACSL4) are associated with non-syndromic intellectual disabilities...
  34. pmc Breast cancer molecular subtypes: from TNBC to QNBC
    Jane Date C Hon
    Department of Pathology, Rutgers Robert Wood Johnson Medical School Piscataway, NJ, USA
    Am J Cancer Res 6:1864-1872. 2016
    ..pathway proteins are preferentially expressed in QNBC that may serve as effective targets for treatment, such as ACSL4, SKP2 and EGFR...
  35. ncbi Identification and characterization of a highly conserved protein absent in the Alport syndrome (A), mental retardation (M), midface hypoplasia (M), and elliptocytosis (E) contiguous gene deletion syndrome (AMME)
    F Vitelli
    Genetica Medica, Policlinico Le Scotte, Siena, Italy
    Genomics 55:335-40. 1999
    ..of the COL4A5 gene, no other genes are known in the region with the exception of our recent finding of the FACL4 gene...
  36. ncbi Up-regulation of fatty acid metabolizing-enzymes mRNA in rat spinal cord during persistent peripheral local inflammation
    A Benani
    Laboratoire de Pharmacologie, Unité Mixte de Recherche 7561 CNRS Université Henri Poincaré Nancy I, Faculte de Medecine, 54505 Vandoeuvre les Nancy, France
    Eur J Neurosci 18:1904-14. 2003
    ..Similar spinal up-regulation of the isoforms ACS2, ACS3, ACS4, and of ACO was detected early after 30 min, reaching a maximal after 6 h post-injection...
  37. ncbi Genes involved in fatty acid partitioning and binding, lipolysis, monocyte/macrophage recruitment, and inflammation are overexpressed in the human fatty liver of insulin-resistant subjects
    Jukka Westerbacka
    Department of Medicine, Division of Diabetes, University of Helsinki, P O Box 700, Room C418B, FIN 00029 HUCH, Helsinki, Finland
    Diabetes 56:2759-65. 2007
    ..The objective of this study is to quantitate expression of genes possibly contributing to insulin resistance and fat deposition in the human liver...
  38. pmc The BTB ubiquitin ligases ETO1, EOL1 and EOL2 act collectively to regulate ethylene biosynthesis in Arabidopsis by controlling type-2 ACC synthase levels
    Matthew J Christians
    Department of Genetics, 425 G Henry Mall, University of Wisconsin, Madison, WI 53706 1574, USA
    Plant J 57:332-45. 2009
    ..Like ETO1, EOL1 interacts with type-2 ACSs (ACS4, ACS5 and ACS9), but not with type-1 or type-3 ACSs, or with type-2 ACS mutants that stabilize the corresponding ..
  39. doi Analyses of mental dysfunction-related ACSl4 in Drosophila reveal its requirement for Dpp/BMP production and visual wiring in the brain
    Yi Zhang
    Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, People s Republic of China
    Hum Mol Genet 18:3894-905. 2009
    ..Mutations in ACSL4 are associated with non-syndromic X-linked mental retardation (MRX)...
  40. pmc A combinatorial interplay among the 1-aminocyclopropane-1-carboxylate isoforms regulates ethylene biosynthesis in Arabidopsis thaliana
    Atsunari Tsuchisaka
    Plant Gene Expression Center, Albany, California 94710, USA
    Genetics 183:979-1003. 2009
    ..understand the function of this important enzyme, we analyzed the entire family of nine ACS isoforms (ACS1, ACS2, ACS4-9, and ACS11) encoded in the Arabidopsis genome...
  41. pmc Arabidopsis RING E3 ligase XBAT32 regulates lateral root production through its role in ethylene biosynthesis
    Madhulika E Prasad
    Department of Biology, Dalhousie University, Halifax, Nova Scotia, Canada B3H 4R2
    Plant Physiol 153:1587-96. 2010
    ..XBAT32 interacts with the ethylene biosynthesis enzymes AMINOCYCLOPROPANE-1-CARBOXYLIC ACID SYNTHASE4 (ACS4) and ACS7 in yeast-two-hybrid assays...
  42. pmc Peroxisomal acyl-CoA synthetases
    Paul A Watkins
    Hugo W Moser Research Institute, Baltimore, MD, USA
    Biochim Biophys Acta 1822:1411-20. 2012
    ..synthetases encoded by the human and mouse genomes, only a few have been reported to be peroxisomal, including ACSL4, SLC27A2, and SLC27A4...
  43. doi Evaluation of the porcine ACSL4 gene as a candidate gene for meat quality traits in pigs
    J Corominas
    Departament de Ciencia Animal i dels Aliments, Facultat de Veterinaria, UAB, Bellaterra, 08193, Spain
    Anim Genet 43:714-20. 2012
    ..Previous studies in our group evaluated ACSL4 as a positional candidate gene for quantitative trait loci located on chromosome X in an Iberian × Landrace cross...
  44. pmc Long chain fatty Acyl-CoA synthetase 4 is a biomarker for and mediator of hormone resistance in human breast cancer
    Xinyu Wu
    Department of Neuroscience and Physiology, New York University School of Medicine, New York, New York, United States of America
    PLoS ONE 8:e77060. 2013
    The purpose of this study was to determine the role of long-chain fatty acyl-CoA synthetase 4 (ACSL4) in breast cancer...
  45. pmc Arachidonic acid downregulates acyl-CoA synthetase 4 expression by promoting its ubiquitination and proteasomal degradation
    Chin Fung Kelvin Kan
    Department of Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304
    J Lipid Res 55:1657-67. 2014
    b>ACSL4 is a member of the long-chain acyl-CoA synthetase (ACSL) family with a marked preference for arachidonic acid (AA) as its substrate...
  46. doi Distribution of H-FABP and ACSL4 gene polymorphisms and their associations with intramuscular fat content and backfat thickness in different pig populations
    J N Chen
    College of Life Science, Sichuan Agricultural University, Ya an, China
    Genet Mol Res 13:6759-72. 2014
    Here, we analyzed the distribution of H-FABP/(HinfI, MspI, and HaeIII) and ACSL4/RsaI polymorphisms, and the associations of these 4 polymorphic loci with intramuscular fat (IMF) content and backfat thickness (BFT) in Yanan, Jinhua, ..
  47. pmc PPARδ activation induces hepatic long-chain acyl-CoA synthetase 4 expression in vivo and in vitro
    Chin Fung Kelvin Kan
    Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304, United States
    Biochim Biophys Acta 1851:577-87. 2015
    The arachidonic acid preferred long-chain acyl-CoA synthetase 4 (ACSL4) is a key enzyme for fatty acid metabolism in various metabolic tissues...
  48. doi A novel 47.2 Mb duplication on chromosomal bands Xq21.1-25 associated with mental retardation
    Zhijuan Jin
    MOE Shanghai Key Laboratory of Children s Environmental Health, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, PR China Department of Developmental and Behavioral Pediatrics, Shanghai Children s Medical Center, Shanghai Jiaotong University School of Medicine, Shanghai 200127, PR China
    Gene 567:98-102. 2015
    ..Ten genes (i.e., ZNF711, SRPX2, RAB40AL, MID2, ACSL4, PAK3, UBE2A, UPF3B, CUL4B, and GRIA3) in the duplication interval have been associated with mental retardation...
  49. pmc Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death
    Scott J Dixon
    Department of Biology, Stanford University, 337 Campus Drive, Stanford, California 94305, United States
    ACS Chem Biol 10:1604-9. 2015
    ..genes involved in small-molecule-induced nonapoptotic cell death, including mediators of fatty acid metabolism (ACSL4) and lipid remodeling (LPCAT3) in ferroptosis...
  50. pmc Acyl-CoA synthetase-4, a new regulator of mTOR and a potential therapeutic target for enhanced estrogen receptor function in receptor-positive and -negative breast cancer
    Ulises D Orlando
    Biomedical Research Institute, INBIOMED, Department of Biochemistry, School of Medicine, University of Buenos Aires, CABA, Buenos Aires, Argentina
    Oncotarget 6:42632-50. 2015
    Although the role of acyl-CoA synthetase 4 (ACSL4) in mediating an aggressive phenotype is well accepted, there is little evidence as to the early steps through which ACSL4 increases tumor growth and progression...
  51. doi Pinolenic Acid Downregulates Lipid Anabolic Pathway in HepG2 Cells
    Ah Ron Lee
    Department of Food and Nutrition, College of Human Ecology, Seoul National University, 1 Gwanak ro, Gwanak Gu, Seoul, 08826, Korea
    Lipids 51:847-55. 2016
    ..lipoprotein uptake (LDLr) and of genes that may be involved in the downregulation of the lipogenic pathway (ACSL3, ACSL4, and ACSL5) were determined by qPCR. LDLR protein levels were measured by Western blot analysis...
  52. doi Astrocyte arachidonate and palmitate uptake and metabolism is differentially modulated by dibutyryl-cAMP treatment
    D R Seeger
    Department of Biomedical Sciences, University of North Dakota, Grand Forks, ND 58203, USA
    Prostaglandins Leukot Essent Fatty Acids 110:16-26. 2016
    ..dBcAMP treatment increased expression of Acsl3 (4.8-fold) and Acsl4 (1...
  53. pmc Transcription of TIR1-Controlled Genes Can be Regulated within 10 Min by an Auxin-Induced Process. Can TIR1 be the Receptor?
    Corinna Labusch
    Abteilung Molekulare Ertragsphysiologie, Institut für Gartenbauliche Produktionssysteme, Leibniz Universität Hannover Hannover, Germany
    Front Plant Sci 7:995. 2016
    ..d6pkl1-1, d6pkl3-2, d6pkl1-1/d6pkl2-2, and d6pkl1-1/d6pkl3-2), of fatty acid metabolism (fad2-1, fad6-1, ssi2, lacs4, lacs9, and lacs4/lacs9) and receptors (tir1, tir1/afb2, and tir1/afb3) and compared them to the wild type...
  54. doi Identification of ACSL4 as a biomarker and contributor of ferroptosis
    Hua Yuan
    School of Nursing, Jilin University, Changchun, Jilin, 130021, China
    Biochem Biophys Res Commun 478:1338-43. 2016
    ..Here, we show that acyl-CoA synthetase long-chain family member 4 (ACSL4) is required for ferroptotic cancer cell death. Compared with ferroptosis-sensitive cells (e.g...
  55. ncbi Complementation analysis of mutants of 1-aminocyclopropane- 1-carboxylate synthase reveals the enzyme is a dimer with shared active sites
    A S Tarun
    Plant Gene Expression Center, Albany, California 94710, USA
    J Biol Chem 273:12509-14. 1998
    ..Furthermore, hybrid complementation shows that another tomato isoenzyme, Le-ACS4, can dimerize and that Le-ACS2 and Le-ACS4 have limited capacity for heterodimerization...
  56. ncbi Regulation by adrenocorticotropic hormone and arachidonate of the expression of acyl-CoA synthetase 4, an arachidonate-preferring enzyme expressed in steroidogenic tissues
    Y Y Cho
    Tohoku University Gene Research Center, Tohoku University, Tsutsumidori Amamiya, Aoba, Sendai, 981 8555, Japan
    Biochem Biophys Res Commun 274:741-5. 2000
    Acyl-CoA synthetase 4 (ACS4) is an arachidonate-preferring enzyme abundant in steroidogenic tissues...
  57. ncbi [Radiological progression of internal femoro-tibial osteoarthritis in gonarthrosis. Chondro-protective effect of chondroitin sulfates ACS4-ACS6]
    Pierre Mathieu
    Service de rhumatologie du Pr Vignon, CH Lyon Sud, 165, Chemin du Grand Revoyet, 69495 Pierre Benite
    Presse Med 31:1386-90. 2002
    To confirm the structure-modulating properties of ACS4-ACS6 in gonathrosis by measuring the modifications in minimum joint space width, the mean thickness and the mean surface of the cartilage in internal femorotibial function.
  58. ncbi Eicosapentaenoic acid-induced apoptosis depends on acyl CoA-synthetase
    Hilde Heimli
    Institute for Nutrition Research, University of Oslo, Blindern, Oslo, Norway
    Lipids 38:263-8. 2003
    ..Several different approaches were tried to overexpress ACS4 in EPA-insensitive lymphoma cell lines, but we did not obtain viable cells with high expression of acyl-CoA ..
  59. ncbi Identification of major proteins in the lipid droplet-enriched fraction isolated from the human hepatocyte cell line HuH7
    Yasuyuki Fujimoto
    Department of Molecular Pathology, Faculty of Pharmaceutical Sciences, Teikyo University, 1091 1 Suarashi, Sagamiko, Tsukui, Kanagawa 199 0195, Japan
    Biochim Biophys Acta 1644:47-59. 2004
    ..These results suggest that a specific set of proteins is enriched in the lipid droplet-enriched fraction and that 17betaHSD11 localizes specifically in the fraction...
  60. pmc Unique and overlapping expression patterns among the Arabidopsis 1-amino-cyclopropane-1-carboxylate synthase gene family members
    Atsunari Tsuchisaka
    Plant Gene Expression Center, Albany, California 94710, USA
    Plant Physiol 136:2982-3000. 2004
    ..The Arabidopsis genome encodes nine ACS polypeptides that form eight functional (ACS2, ACS4-9, and ACS11) homodimers and one nonfunctional (ACS1) homodimer...
  61. ncbi Assignment of the acyl-CoA synthetase long-chain family member 4 (ACSL4) gene to porcine chromosome X
    A Mercade
    Departament de Ciencia Animal i dels Aliments, Facultat de Veterinaria, Universitat Autonoma de Barcelona, Bellaterra 08193, Spain
    Anim Genet 36:76. 2005
  62. ncbi Impaired expression of acyl-CoA synthetase 5 in sporadic colorectal adenocarcinomas
    Nikolaus Gassler
    Institute of Pathology, University of Heidelberg, Heidelberg, Germany
    J Pathol 207:295-300. 2005
    ..Whilst an increase in ACS4 expression has been associated with colorectal carcinogenesis, little is known about possible pathogenetic ..
  63. pmc X linked mental retardation: a clinical guide
    F L Raymond
    Cambridge Institute of Medical Research, Department of Medical Genetics, University of Cambridge, Addenbrooke s Hospital, Cambridge, CB2 2XY, UK
    J Med Genet 43:193-200. 2006
    ..relative prevalence of genes causing only non-syndromic mental retardation (IL1RAPL1, TM4SF2, ZNF41, FTSJ1, DLG3, FACL4, PAK3, ARHGEF6, FMR2, and GDI) is summarised...
  64. doi JNK deficiency enhances fatty acid utilization and diverts glucose from oxidation to glycogen storage in cultured myotubes
    Ravi Vijayvargia
    Department of Physiology and Biophysics, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, Piscataway, New Jersey, USA
    Obesity (Silver Spring) 18:1701-9. 2010
    ..increased NEFA utilization was coupled to increased expressions of selective NEFA handling genes including Cd36, Acsl4, and Chka, and enhanced palmitic acid (PA)-dependent suppression of acetyl-CoA carboxylase (Acc)...
  65. doi Hepatic gene expression of Caucasian and African-American patients with obesity-related non-alcoholic fatty liver disease
    Maria Stepanova
    Center for Liver Diseases at Inova Fairfax Hospital, Falls Church, VA 22042, USA
    Obes Surg 20:640-50. 2010
    ..The aim of this study is to assess differences in the hepatic gene expression of African-American and Caucasian patients with NAFLD who had undergone bariatric surgery...
  66. pmc A novel TIP30 protein complex regulates EGF receptor signaling and endocytic degradation
    Chengliang Zhang
    Department of Biomedical and Integrative Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    J Biol Chem 286:9373-81. 2011
    ..describe a protein complex consisting of TIP30, endophilin B1, and acyl-CoA synthetase long chain family member 4 (ACSL4) that interacts with Rab5a and regulates EGFR endocytosis and signaling...
  67. pmc High ACSL5 transcript levels associate with systemic lupus erythematosus and apoptosis in Jurkat T lymphocytes and peripheral blood cells
    Antonio Catalá-Rabasa
    Department of Cell Biology and Immunology, Instituto de Parasitologia y Biomedicina Lopez Neyra Consejo Superior de Investigaciones Cientificas, Granada, Spain
    PLoS ONE 6:e28591. 2011
    ..The aim of this work was to assess among the ACSL isoforms the involvement of ACSL2, ACSL4 and ACSL5 in SLE pathogenesis.
  68. doi Role of intramitochondrial arachidonic acid and acyl-CoA synthetase 4 in angiotensin II-regulated aldosterone synthesis in NCI-H295R adrenocortical cell line
    Pablo G Mele
    Department of Biochemistry, School of Medicine, University of Buenos Aires, Institute of Biomedical Investigations, UBA Consejo Nacional de Investigaciones Científicas y Técnicas, Paraguay 2155, 5 Floor, C1121ABG Buenos Aires, Argentina
    Endocrinology 153:3284-94. 2012
    ..We also demonstrate the role of protein tyrosine phosphatases regulating acyl-CoA synthetase 4 and steroidogenic acute regulatory protein induction, and hence ANG II-stimulated aldosterone synthesis...
  69. doi Characterization of the mouse promoter region of the acyl-CoA synthetase 4 gene: role of Sp1 and CREB
    Ulises Orlando
    Institute of Biomedical Investigations INBIOMED, Department of Biochemistry, School of Medicine, University of Buenos Aires, National Research Council, Buenos Aires, Argentina
    Mol Cell Endocrinol 369:15-26. 2013
    Acyl-CoA synthetase 4 (Acsl4) is involved in several cellular functions including steroidogenesis, synaptic development and cancer metastasis...
  70. doi Xq22.3-q23 deletion including ACSL4 in a patient with intellectual disability
    Anastasia Gazou
    Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tuebingen, Germany
    Am J Med Genet A 161:860-4. 2013
    Mutations or deletions of ACSL4 (FACL4, OMIM 300157) are a rare cause of non-syndromic X-linked intellectual disability...
  71. pmc Fine mapping of fatness QTL on porcine chromosome X and analyses of three positional candidate genes
    Junwu Ma
    INRA, UMR444 Laboratoire de Génétique Cellulaire, Castanet Tolosan F 31326, France
    BMC Genet 14:46. 2013
    ..White Duroc × Erhualian constructed by INRA and JXAU respectively) and furthermore, to determine whether these QTL are caused by mutations in three positional candidate genes (ACSL4, SERPINA7 and IRS4) involved in lipid biosynthesis.
  72. pmc Diminished acyl-CoA synthetase isoform 4 activity in INS 832/13 cells reduces cellular epoxyeicosatrienoic acid levels and results in impaired glucose-stimulated insulin secretion
    Eric L Klett
    Department of Medicine, Division of Endocrinology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27599 7172, USA
    J Biol Chem 288:21618-29. 2013
    ..Because the predominantly expressed Acsl isoforms in INS 832/13 cells are Acsl4 and -5, we characterized the role of these Acsls in beta-cell function by using siRNA to knock down Acsl4 or Acsl5...
  73. doi miRNA expression is modulated over time after focal ischaemia: up-regulation of miR-347 promotes neuronal apoptosis
    Carme Gubern
    Grup de Recerca Cerebrovascular, Servei de Neurologia, Institut d Investigació Biomèdica de Girona Dr Josep Trueta, Hospital Universitari de Girona, Spain
    FEBS J 280:6233-46. 2013
    ..Analysis of four of these targets (Acsl4, Arf3, Btg2 and Dpysl5) showed them to be differentially regulated by ischaemia at the transcriptional or post-..
  74. doi The Arabidopsis RING-type E3 ligase XBAT32 mediates the proteasomal degradation of the ethylene biosynthetic enzyme, 1-aminocyclopropane-1-carboxylate synthase 7
    Wendy J Lyzenga
    Department of Biology, Dalhousie University, Halifax NS B3H 4R2, Canada
    Plant J 71:23-34. 2012
    ..work has suggested that XBAT32 modulates ethylene production by ubiquitinating two ethylene biosynthesis enzymes, ACS4 (type-II isoform) and ACS7 (type-III isoform)...
  75. doi A novel role of brain-type ACS4 isotype in neuronal differentiation
    Yong Yeon Cho
    College of Pharmacy, The Catholic University of Korea, Jibong ro, Wonmi gu, Bucheon si, Gyeonggi Do, Republic of Korea
    Biochem Biophys Res Commun 419:505-10. 2012
    Acyl-CoA synthetase (ACS4) is an arachidonate preferring acyl-CoA synthetase and has been shown to play an important role in lipid metabolism...
  76. ncbi ACS4, a primary indoleacetic acid-responsive gene encoding 1-aminocyclopropane-1-carboxylate synthase in Arabidopsis thaliana. Structural characterization, expression in Escherichia coli, and expression characteristics in response to auxin [corrected]
    S Abel
    Plant Gene Expression Center, Albany, California 94710, USA
    J Biol Chem 270:19093-9. 1995
    ..A., Shen,N. N.F., and Theologis, A. (1992) Poc. Natl. Acad. Sci. U.S.A. 89, 11046-11050). In etiolated seedlings, ACS4 is specifically induced by indoleacetic acid (IAA)...
  77. ncbi Characterization of three members of the ACC synthase gene family in Solanum tuberosum L
    L J Destéfano-Beltrán
    Laboratorium voor Genetica, Universiteit Gent, Belgium
    Mol Gen Genet 246:496-508. 1995
    ..gene in potato, ST-ACS2, was found in a 4 kb region and shows a gene structure similar to that of the tomato LE-ACS4 gene and to the mung bean VR-ACS4 and VR-ACS5 genes...
  78. ncbi LE-ACS4, a fruit ripening and wound-induced 1-aminocyclopropane-1-carboxylate synthase gene of tomato (Lycopersicon esculentum). Expression in Escherichia coli, structural characterization, expression characteristics, and phylogenetic analysis
    J E Lincoln
    Plant Gene Expression Center, Albany, California 94710
    J Biol Chem 268:19422-30. 1993
    ..Campbell, A. D., and Theologis, A. (1991) J. Mol. Biol. 222, 937-961). Two members of the family, LE-ACS2 and LE-ACS4, are induced during fruit ripening and upon treatment of mature green fruits with exogenous ethylene (C2H4) in a ..
  79. pmc A novel arachidonate-preferring acyl-CoA synthetase is present in steroidogenic cells of the rat adrenal, ovary, and testis
    M J Kang
    Tohoku University Gene Research Center, School of Medicine, Tohoku University, Aoba, Sendai, Japan
    Proc Natl Acad Sci U S A 94:2880-4. 1997
    ..This newly identified ACS (designated ACS4) contains 670 amino acids and is 68% identical to rat ACS3, a previously characterized ACS that is highly expressed ..
  80. ncbi Differential induction of seven 1-aminocyclopropane-1-carboxylate synthase genes by elicitor in suspension cultures of tomato (Lycopersicon esculentum)
    J H Oetiker
    Department of Vegetable Crops, University of California at Davis 95616, USA
    Plant Mol Biol 34:275-86. 1997
    ..In contrast, the genes LE-ACS1B, LE-ACS3 and LE-ACS4 were constitutively expressed and LE-ACS1B was present at all times at a particularly high level...
  81. pmc Alport syndrome, mental retardation, midface hypoplasia, and elliptocytosis: a new X linked contiguous gene deletion syndrome?
    J J Jonsson
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520 8005, USA
    J Med Genet 35:273-8. 1998
    ....
  82. pmc Differential expression and internal feedback regulation of 1-aminocyclopropane-1-carboxylate synthase, 1-aminocyclopropane-1-carboxylate oxidase, and ethylene receptor genes in tomato fruit during development and ripening
    A Nakatsuka
    Laboratory of Postharvest Agriculture, Faculty of Agriculture, Okayama University, Tsushima, Okayama, 700 8530 Japan
    Plant Physiol 118:1295-305. 1998
    ..The abundance of LE-ACS2, LE-ACS4, and NR mRNAs increased in the ripening fruit concomitant with a burst in ethylene production...
  83. ncbi Roles of PLC-beta2 and -beta3 and PI3Kgamma in chemoattractant-mediated signal transduction
    Z Li
    Department of Pharmacology, University of Rochester, Rochester, NY 14642, USA
    Science 287:1046-9. 2000
    ..The PLC pathways also appear to inhibit the chemotactic activity induced by certain chemoattractants and to suppress TI-IglambdaL production...
  84. ncbi Expression of fatty acid-CoA ligase 4 during development and in brain
    Y Cao
    Huntsman Cancer Institute, 2000 Circle of Hope, Suite 5360, University of Utah, Salt Lake City, UT, USA
    FEBS Lett 467:263-7. 2000
    ..We have cloned previously the human long-chain fatty acid-CoA ligase 4 (FACL4), which is a central enzyme in controlling the free arachidonic acid level in cells and thereby regulating ..
  85. ncbi Identification and characterization of mouse orthologs of the AMMECR1 and FACL4 genes deleted in AMME syndrome: orthology of Xq22.3 and MmuXF1-F3
    F Vitelli
    Genetica Medica, Dipartimento Biologia Molecolare, Universita di Siena, Italy
    Cytogenet Cell Genet 88:259-63. 2000
    ..3, comprising several genes including COL4A5, FACL4 and AMMECR1...
  86. ncbi Expression and characterization of recombinant rat Acyl-CoA synthetases 1, 4, and 5. Selective inhibition by triacsin C and thiazolidinediones
    J H Kim
    Departments of Nutrition and Pediatrics, University of North Carolina, Chapel Hill, NC 27599 7400, USA
    J Biol Chem 276:24667-73. 2001
    ..In order to test this hypothesis, we cloned and purified rat ACS1, ACS4, and ACS5, the isoforms present in liver and fat cells, expressed the isoforms as ACS-Flag fusion proteins in ..
  87. ncbi Acyl-CoA synthetase isoforms 1, 4, and 5 are present in different subcellular membranes in rat liver and can be inhibited independently
    T M Lewin
    Departments of Nutrition and Pediatrics, University of North Carolina, Chapel Hill, NC 27599, USA
    J Biol Chem 276:24674-9. 2001
    ..these isoforms were regulated independently, non-cross-reacting peptide antibodies were raised against ACS1, ACS4, and ACS5...
  88. ncbi Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for acyl-CoA synthetase 4 deficiency
    Y Y Cho
    Tohoku University Gene Research Center, Sendai, 981 8555, Japan
    Biochem Biophys Res Commun 284:993-7. 2001
    ..b>ACS4 is an arachidonate-preferring enzyme abundant in steroidogenic tissues and postulated to modulate eicosanoid ..
  89. ncbi Rat liver acyl-CoA synthetase 4 is a peripheral-membrane protein located in two distinct subcellular organelles, peroxisomes, and mitochondrial-associated membrane
    Tal M Lewin
    Department of Nutrition and Pediatrics, University of North Carolina, Chapel Hill, NC 27599, USA
    Arch Biochem Biophys 404:263-70. 2002
    ..Therefore, we examined the subcellular location of ACS1, ACS4, and ACS5 in rat liver to determine which isoform was present in peroxisomes, whether the ACSs were intrinsic ..
  90. ncbi Do long-chain acyl-CoA synthetases regulate fatty acid entry into synthetic versus degradative pathways?
    Rosalind A Coleman
    University of North Carolina, Chapel Hill, 27599 7461, USA
    J Nutr 132:2123-6. 2002
    ..b>ACS4 may provide acyl-CoA for both synthesis and peroxisomal oxidation, depending on whether the enzyme is associated ..
  91. ncbi [A new mechanism of action of chondroitin sulfates ACS4-ACS6 in osteoarthritic cartilage]
    Pierre Mathieu
    Service de rhumatologie du Pr Vignon, CH Lyon Sud, 165, Chemin du Grand Revoyet, 69495 Pierre Benite
    Presse Med 31:1383-5. 2002
    THE MECHANISMS OF ACTION ALREADY KNOWN: In vitro, chondroïtin sulfate ACS4-ACS6 have a dose-dependent inhibiting effect on the catabolism of proteoglycanes and collagen...
  92. pmc A third MRX family (MRX68) is the result of mutation in the long chain fatty acid-CoA ligase 4 (FACL4) gene: proposal of a rapid enzymatic assay for screening mentally retarded patients
    I Longo
    Medical Genetics, Department of Molecular Biology, University of Siena, Italy
    J Med Genet 40:11-7. 2003
    The gene encoding fatty acid CoA ligase 4 (FACL4) is mutated in families with non-specific X linked mental retardation (MRX) and is responsible for cognitive impairment in the contiguous gene syndrome ATS-MR (Alport syndrome and mental ..
  93. ncbi [Monogenic causes of nonspecific X-linked mental retardation molecular aspects]
    Magdalena Nawara
    Zaklad Genetyki Medycznej, Instytut Matki i Dziecka, Kasprzaka 17a, 01 211 Warszawa, Poland
    Med Wieku Rozwoj 6:281-94. 2002
    ..mental retardation have been identified so far, including FMR2, GDI1, OPHN1, PAK3, ARHGEF6, IL1RAPL, TM4SF2, and FACL4. Four other MECP2, RSK2, ARX, ATR-X are involved in syndromic and nonspecific forms of MR...
  94. ncbi Glypican-3 is overexpressed in human hepatocellular carcinoma
    Young Kwan Sung
    Department of Immunology, Kyungpook National University Medical School, Chung gu, Daegu, Republic of Korea
    Cancer Sci 94:259-62. 2003
    ..We also found that GPC3 is secreted into culture media from cell lines derived from HCC. We conclude that GPC3 is a good molecular marker for HCC...
  95. ncbi Localization of a non-syndromic X-linked mental retardation gene (MRX80) to Xq22-q24
    Lucie Verot
    Center for Molecular and Cellular Genetics, University Lyon I, Villeurbanne, France
    Am J Med Genet A 122:37-41. 2003
    ..mental retardation (NSMR), namely the PAK3 gene, encoding a p21-activated kinase (MRX30 and MRX47) and the FACL4 gene encoding a fatty acyl-CoA ligase (MRX63)...
  96. pmc Heterodimeric interactions among the 1-amino-cyclopropane-1-carboxylate synthase polypeptides encoded by the Arabidopsis gene family
    Atsunari Tsuchisaka
    Plant Gene Expression Center, 800 Buchanan Street, Albany, CA 94710, USA
    Proc Natl Acad Sci U S A 101:2275-80. 2004
    ..The Arabidopsis genome encodes nine ACS polypeptides that form eight functional (ACS2, ACS4-9, ACS11) and one nonfunctional (ACS1) homodimers...
  97. ncbi Association of a long-chain fatty acid-CoA ligase 4 gene polymorphism with depression and with enhanced niacin-induced dermal erythema
    Jonathan Covault
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, Connecticut 06030 2103, USA
    Am J Med Genet B Neuropsychiatr Genet 127:42-7. 2004
    ..Long-chain fatty acid-CoA ligase type 4 (FACL4; MIM 300157) is a key enzyme involved in the metabolism of AA, EPA, and DHA...
  98. ncbi The role of long-chain fatty-acid-CoA ligase 3 in vitamin D3 and androgen control of prostate cancer LNCaP cell growth
    Shengjun Qiao
    Department of Anatomy, Medical School, University of Tampere, 33014, Tampere, Finland
    Biochem Biophys Res Commun 319:358-68. 2004
    ..1alpha,25(OH)(2)D(3) had no significant effect on the expression of FACL1(FACL2), FACL4 and FACL6 except for its downregulation of FACL5 at 24 and 48h by around twofold...
  99. ncbi Revised nomenclature for the mammalian long-chain acyl-CoA synthetase gene family
    Douglas G Mashek
    Departments of Nutrition and Pediatrics, University of North Carolina, Chapel Hill, NC 27599, USA
    J Lipid Res 45:1958-61. 2004
    ..Splice variants of ACSL3, -4, -5, and -6 are cataloged. Suggestions for naming other family members and for the nonmammalian acyl-CoA synthetases are made...
  100. ncbi Characterization of recombinant long-chain rat acyl-CoA synthetase isoforms 3 and 6: identification of a novel variant of isoform 6
    Cynthia G Van Horn
    Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Biochemistry 44:1635-42. 2005
    ..The three recombinant proteins were characterized. Compared to ACSL4, another brain isoform, ACSL3, ACSL6_v1, and ACSL6_v2 showed similarities in kinetic values for CoA, palmitate, ..
  101. ncbi Non-syndromic X-linked mental retardation: from a molecular to a clinical point of view
    A Renieri
    Medical Genetics, Department of Molecular Biology, University of Siena, Siena, Italy
    J Cell Physiol 204:8-20. 2005
    ..The function of four proteins (ACSL4, AT2, SLC6A8, and SAP102) could not be reconciled to a common pathway...

Research Grants6

  1. ROSALIND ANNE COLEMAN; Fiscal Year: 2015
    ..further hypothesize, in keeping with the proposition that each ACSL directs FA towards a specific fate, that the ACSL4 isoform functions to regulate the entry of arachidonate into pathways of phospholipid synthesis versus eicosanoid ..
  2. Eric Klett; Fiscal Year: 2014
    ..1, the PI will selectively knockdown the expression and therefore function of long-chain acyl-CoA synthetase 4 (ACSL4) in mouse islets using adenoviral RNAi technology and examine the effect of the knockdown on GSIS and islet lipid ..
  3. Jingwen Liu; Fiscal Year: 2015
    ..Long-chain acyl-CoAs are formed by a family of five acyl-CoA synthetases (ACSL1, ACSL3, ACSL4, ACSL5, and ACSL-6)...
  4. Reprogramming of X-linked genes by nuclear transfer
    X Tian; Fiscal Year: 2003
    ..These genes include MAOA, XIST. ELF4, FACL4; PLP1, PPEF1, SYP, SYNl, BGN, and TBLl...
  5. Brain Uptake and Utilization of Fatty Acids and Lipids
    Paul Watkins; Fiscal Year: 2004
    ..Mol. Neurosci., which has committed to publish the proceedings of the proposed meeting. ..
  6. XALD: Role of Very Long Chain Fatty Acyl-CoA Synthetases
    Paul Watkins; Fiscal Year: 2006
    ..Furthermore, they will facilitate elucidation of the role of enzymes belonging to the VLACS or BG families in XALD. [unreadable] [unreadable]..