ACOX1

Summary

Gene Symbol: ACOX1
Description: acyl-CoA oxidase 1
Alias: ACOX, PALMCOX, SCOX, peroxisomal acyl-coenzyme A oxidase 1, AOX, acyl-CoA oxidase 1, palmitoyl, acyl-CoA oxidase, straight-chain, acyl-Coenzyme A oxidase 1, palmitoyl, palmitoyl-CoA oxidase, peroxisomal fatty acyl-CoA oxidase, straight-chain acyl-CoA oxidase
Species: human
Products:     ACOX1

Top Publications

  1. Jacometo C, Zhou Z, Luchini D, Trevisi E, Corrêa M, Loor J. Maternal rumen-protected methionine supplementation and its effect on blood and liver biomarkers of energy metabolism, inflammation, and oxidative stress in neonatal Holstein calves. J Dairy Sci. 2016;99:6753-6763 pubmed publisher
    ..Expression of carnitine palmitoyltransferase 1A (CPT1A) was overall greater and acyl-CoA oxidase 1 (ACOX1) was lower in MET calves, indicating alterations in fatty acid oxidation...
  2. Shi Q, Sun N, Kou H, Wang H, Zhao H. Chronic effects of mercury on Bufo gargarizans larvae: Thyroid disruption, liver damage, oxidative stress and lipid metabolism disorder. Ecotoxicol Environ Saf. 2018;164:500-509 pubmed publisher
    ..regulated mRNA expression of carnitine palmitoyltransferase (CPT), sterol carrier protein (SCP), acyl-CoA oxidase (ACOX) and peroxisome proliferator-activated receptor α (PPAPα), but significantly up regulated mRNA expression of ..
  3. Madureira T, Malhão F, Simões T, Pinheiro I, Lopes C, Gonçalves J, et al. Sex-steroids and hypolipidemic chemicals impacts on brown trout lipid and peroxisome signaling - Molecular, biochemical and morphological insights. Comp Biochem Physiol C Toxicol Pharmacol. 2018;212:1-17 pubmed publisher
    ..receptor alpha (PPAR?), PPAR?Ba and acyl-CoA long chain synthetase 1 (Acsl1), while ER?-1, acyl-CoA oxidase 1-3I (Acox1-3I), Acox3, PPAR?, catalase (Cat), urate oxidase (Uox), fatty acid binding protein 1 (Fabp1) and apolipoprotein AI ..
  4. Xu P, Wang H, Kayoumu A, Wang M, Huang W, Liu G. Diet rich in Docosahexaenoic Acid/Eicosapentaenoic Acid robustly ameliorates hepatic steatosis and insulin resistance in seipin deficient lipodystrophy mice. Nutr Metab (Lond). 2015;12:58 pubmed publisher
    ..proliferator-activated receptor α (PPARα), carnitine palmitoyltransferase (CPT) and acyl-CoA oxidase 1 (ACOX1) were elevated in both WT and SKO groups on DHA/EPA diets...
  5. Yang S, Zhang W, Zhen Q, Gao R, Du T, Xiao X, et al. Impaired adipogenesis in adipose tissue associated with hepatic lipid deposition induced by chronic inflammation in mice with chew diet. Life Sci. 2015;137:7-13 pubmed publisher
    ..triacylglycerol transfer protein (MTP), carnitine palmitoyltransferase 1a (CPT1a) and acyl-coenzyme a oxidase 1 (ACOX1)...
  6. Jung T, Hwang H, Hong H, Yoo H, Baik S, Choi K. BAIBA attenuates insulin resistance and inflammation induced by palmitate or a high fat diet via an AMPK-PPARδ-dependent pathway in mice. Diabetologia. 2015;58:2096-105 pubmed publisher
    ..with fatty acid oxidation, such as carnitine palmitoyltransferase 1 (Cpt1), acyl-CoA oxidase (Aco; also known as Acox1) and fatty acid binding protein 3 (Fabp3); this effect of BAIBA was significantly reduced by compound C and PparÎ..
  7. Mohammed Geba K, Arrutia F, Do Huu H, Borrell Y, Galal Khallaf A, Ardura A, et al. VY6, a ?-lactoglobulin-derived peptide, altered metabolic lipid pathways in the zebra fish liver. Food Funct. 2016;7:1968-74 pubmed publisher
    ..Dose-dependent increases of the mRNA levels of the genes coding for the enzymes acyl coenzyme A oxidase 1 (acox1) and lipoprotein lipase (lpl) were also found...
  8. Qian G, Fan W, Ahlemeyer B, Karnati S, Baumgart Vogt E. Peroxisomes in Different Skeletal Cell Types during Intramembranous and Endochondral Ossification and Their Regulation during Osteoblast Differentiation by Distinct Peroxisome Proliferator-Activated Receptors. PLoS ONE. 2015;10:e0143439 pubmed publisher
    ..the PPRE-mediated luciferase expression and up-regulated peroxisomal gene transcription (Pex11, Pex13, Pex14, Acox1 and Cat), whereas the PPARß antagonist GSK0660 led to repression of the PPRE and a decrease of the ..
  9. Bi X, Liu W, Xia X, Chen L, Mu T, Liu J, et al. Effects of Callistephus chinensis flower polyphones on improving metabolic disorders in high-fat diet-induced mice. Food Funct. 2014;5:3304-10 pubmed publisher
    ..proliferator-activated receptor (PPARα) and the gene involved in PPARα, Peroxisomal acyl-CoA oxidase (ACOX), were markedly up-regulated at protein levels by CCF polyphones...

More Information

Publications134 found, 100 shown here

  1. Sun Q, Zhang W, Zhong W, Sun X, Zhou Z. Dietary Fisetin Supplementation Protects Against Alcohol-Induced Liver Injury in Mice. Alcohol Clin Exp Res. 2016;40:2076-2084 pubmed publisher
    ..hepatic steatosis through increasing plasma adiponectin levels and hepatic protein levels of p-AMPK, ACOX1, CYP4A, and MTTP...
  2. Silva P, Weber W, Crooker B, Collier R, Thatcher W, Chebel R. Hepatic mRNA expression for genes related to somatotropic axis, glucose and lipid metabolisms, and inflammatory response of periparturient dairy cows treated with recombinant bovine somatotropin. J Dairy Sci. 2017;100:3983-3999 pubmed publisher
    ..tended to upregulate the mRNA expression for genes involved in gluconeogenesis (PCK1) and fatty acid ?-oxidation (ACOX1), and downregulated the mRNA expression for genes involved in inflammation (TNFRSF1A, ICAM1, CXCL1, MYD88, HIF1A, ..
  3. Coimbra A, Peixoto M, Coelho I, Lacerda R, Carvalho A, Gesto M, et al. Chronic effects of clofibric acid in zebrafish (Danio rerio): a multigenerational study. Aquat Toxicol. 2015;160:76-86 pubmed publisher
    ..In F1 an up-regulation of male hepatic pparaa, pparb and acox transcript levels was observed, suggesting an activation of the fatty acid metabolism (provided that transcript ..
  4. Liu D, Yang A, Wu C, Guo P, Proksch P, Lin W. Lipid-lowering effects of farnesylquinone and related analogues from the marine-derived Streptomyces nitrosporeus. Bioorg Med Chem Lett. 2014;24:5288-93 pubmed publisher
    ..PGC-1α), as well as their downstream genes carnitine palmitoyltransterase-1 (CPT-1), acyl-coenzyme A oxidase 1 (ACOX), malonyl CoA decarboxylase 1 (MCD1), pyruvate dehydrogenase kinase 4 (PDK4), and cholesterol 7α -hydroxylase (..
  5. Suarez J, Rivera P, Arrabal S, Crespillo A, Serrano A, Baixeras E, et al. Oleoylethanolamide enhances β-adrenergic-mediated thermogenesis and white-to-brown adipocyte phenotype in epididymal white adipose tissue in rat. Dis Model Mech. 2014;7:129-41 pubmed publisher
    ..The enhancement of the fatty-acid β-oxidation factors Cpt1b and Acox1 in eWAT was accompanied by an upregulation of de novo lipogenesis and reduced expression of the unsaturated-fatty-..
  6. Si X, Zhou Z, Strappe P, Blanchard C. A comparison of RS4-type resistant starch to RS2-type resistant starch in suppressing oxidative stress in high-fat-diet-induced obese rats. Food Funct. 2017;8:232-240 pubmed publisher
    ..the gluconeogenesis associated gene GAPDH were all significantly down-regulated, whilst the lipid oxidation gene Acox1 and the liver function genes Gsta2, Nqo1, and Gclm were up-regulated in both administered groups...
  7. Han H, Qiu F, Zhao H, Tang H, Li X, Shi D. Dietary Flaxseed Oil Prevents Western-Type Diet-Induced Nonalcoholic Fatty Liver Disease in Apolipoprotein-E Knockout Mice. Oxid Med Cell Longev. 2017;2017:3256241 pubmed publisher
    ..levels of genes involved in de novo fat synthesis (SREBP-1c, ACC), triacylglycerol catabolism (PPAR?, CPT1A, and ACOX1), inflammation (NF-?B, IL-6, TNF-?, and MCP-1), and oxidative stress (ROS, MDA, GSH, and SOD).
  8. Li Y, Zhao Y, Deng H, Chen A, Chai L. Endocrine disruption, oxidative stress and lipometabolic disturbance of Bufo gargarizans embryos exposed to hexavalent chromium. Ecotoxicol Environ Saf. 2018;166:242-250 pubmed publisher
    ..208 and 416 μg Cr6+ L-1, but mRNA expression of fatty acid β-oxidation-related genes (ACOX, CPT, and SCP) was significantly upregulated at 416 μg Cr6+ L-1...
  9. Ferreira D, Fiamoncini J, Prist I, Ariga S, de Souza H, de Lima T. Novel role of TLR4 in NAFLD development: Modulation of metabolic enzymes expression. Biochim Biophys Acta. 2015;1851:1353-9 pubmed publisher
    ..TLR4 deficiency enhanced the expression of several enzymes involved in the oxidation of fatty acids, as follows: ACOX, CPT-1, MTPa, MTBb, PBE and 3-ketoacyl-CoA thiolase...
  10. Kim J, Qu A, Reddy J, Gao B, Gonzalez F. Hepatic oxidative stress activates the Gadd45b gene by way of degradation of the transcriptional repressor STAT3. Hepatology. 2014;59:695-704 pubmed publisher
    ..STAT3 degradation was induced by forced overexpression of the PPARα target gene-encoded enzyme ACOX1, which produces increased H(2)O(2) as a byproduct of fatty acid β-oxidation...
  11. Yoo H, Bradford B, Kosyk O, Uehara T, Shymonyak S, Collins L, et al. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: kidney effects. J Toxicol Environ Health A. 2015;78:32-49 pubmed publisher
    ..strains kidney-specific effects of TCE included induction of peroxisome proliferator-marker genes Cyp4a10 and Acox1, increased cell proliferation, and expression of KIM-1, a marker of tubular damage and regeneration...
  12. Morita M, Kanai M, Mizuno S, Iwashima M, Hayashi T, Shimozawa N, et al. Baicalein 5,6,7-trimethyl ether activates peroxisomal but not mitochondrial fatty acid beta-oxidation. J Inherit Metab Dis. 2008;31:442-9 pubmed publisher
    ..In addition, we found that BTM did not upregulate the expression of ABCD2/ALDR, ABCD3/PMP70, ACOX1 and FATP4 genes but slightly increased ACSVL1 gene expression.
  13. Head B, Bionaz M, Cherian G. Flaxseed and Carbohydrase Enzyme Supplementation Alters Hepatic n-3 Polyunsaturated Fatty Acid Molecular Species and Expression of Genes Associated with Lipid Metabolism in Broiler Chickens. Vet Sci. 2019;6: pubmed publisher
    ..Dietary flax and enzyme treatments up-regulated PPARα target genes CPT1A and ACOX1 while reducing expression of de novo FA synthesis-related genes...
  14. Si X, Strappe P, Blanchard C, Zhou Z. Enhanced anti-obesity effects of complex of resistant starch and chitosan in high fat diet fed rats. Carbohydr Polym. 2017;157:834-841 pubmed publisher
    ..synthesis gene HMGCR, gluconeogenesis gene GAPDH, were significantly down-regulated, whilst lipid oxidation gene Acox1 and liver functional genes Gstm2, Gclc were up-regulated following CL consumption compared with single RS or CS ..
  15. Sychev Z, Hu A, Dimaio T, Gitter A, Camp N, Noble W, et al. Integrated systems biology analysis of KSHV latent infection reveals viral induction and reliance on peroxisome mediated lipid metabolism. PLoS Pathog. 2017;13:e1006256 pubmed publisher
    ..proteins involved in peroxisomal lipid metabolism of very long chain fatty acids, including ABCD3 and ACOX1, are required for the survival of latently infected cells...
  16. Gao J, Qin X, Jiang H, Wang T, Song J, Xu S. Screening and functional analysis of differentially expressed genes in chronic glomerulonephritis by whole genome microarray. Gene. 2016;589:72-80 pubmed publisher
    ..Ptprc, Runx1, Itgb7, Ccl6) and 13 down-regulated genes (Aldh2, Dpyd, Mthfd1, Gldc, Ppar-?, Igf1, Pomc, Oas1a, Gsr, Acox1, Cyp1a1, Ugt2b15, Hsd3b6), which primarily contribute to biological processes such as, cell cycle, cell ..
  17. Massafra V, Milona A, Vos H, Burgering B, van Mil S. Quantitative liver proteomics identifies FGF19 targets that couple metabolism and proliferation. PLoS ONE. 2017;12:e0171185 pubmed publisher
    ..e., Fabp5, Scd1, and Acsl3 and increased the expression of Acox1, involved in FA oxidation. As expected, FGF19 increased the expression of proteins known to drive proliferation (i...
  18. Liu Y, Wang C, Li J, Mei Y, Liang Y. Hypoglycemic and Hypolipidemic Effects of Phellinus Linteus Mycelial Extract from Solid-State Culture in A Rat Model of Type 2 Diabetes. Nutrients. 2019;11: pubmed publisher
    ..PLE also: (i) enhanced expression of CPT1A and ACOX1 (key proteins involved in fatty acid β-oxidation) and low-density lipoprotein receptor (LDLR) in liver, thus ..
  19. Saih F, Andreoletti P, Mandard S, Latruffe N, El Kebbaj M, Lizard G, et al. Protective Effect of Cactus Cladode Extracts on Peroxisomal Functions in Microglial BV-2 Cells Activated by Different Lipopolysaccharides. Molecules. 2017;22: pubmed publisher
    ..of LPS on fatty acid β-oxidation and antioxidant enzymes in peroxisomes: Escherichia coli-LPS decreased ACOX1 activity while Salmonella minnesota-LPS reduced only catalase activity...
  20. Arguin G, Bourzac J, Placet M, Molle C, Paquette M, Beaudoin J, et al. The loss of P2X7 receptor expression leads to increase intestinal glucose transit and hepatic steatosis. Sci Rep. 2017;7:12917 pubmed publisher
    ..P2rx7 -/- mice developed a hepatic steatosis characterized by a reduction of Acaca, Acacb, Fasn and Acox1 mRNA expression, as well as for ACC and FAS protein expression...
  21. Polansky O, Seidlerova Z, Faldynova M, Sisak F, Rychlik I. Protein expression in the liver and blood serum in chickens in response to Salmonella Enteritidis infection. Vet Immunol Immunopathol. 2018;205:10-16 pubmed publisher
    ..Avidin-like LOC431660, THRSP, GATM, GGACT, ACOX1, ALDOB or FABP7 decreased in the liver but not in the serum...
  22. Jia Y, Liu T, Zhou L, Zhu J, Wu J, Sun D, et al. Effects of Di-(2-ethylhexyl) Phthalate on Lipid Metabolism by the JAK/STAT Pathway in Rats. Int J Environ Res Public Health. 2016;13: pubmed
    ..Furthermore, the expression of FABP4, Acox and FASn was decreased in the liver, but increased in adipose tissue...
  23. Camões F, Islinger M, Guimarães S, Kilaru S, Schuster M, Godinho L, et al. New insights into the peroxisomal protein inventory: Acyl-CoA oxidases and -dehydrogenases are an ancient feature of peroxisomes. Biochim Biophys Acta. 2015;1853:111-25 pubmed publisher
    ..dehydrogenases (ACADs) are bona fide peroxisomal proteins in fungi and mammals and together with acyl-CoA oxidases (ACOX) belong to the basic enzymatic repertoire of peroxisomes...
  24. Mahankali M, Farkaly T, Bedi S, Hostetler H, Gomez Cambronero J. Phosphatidic Acid (PA) can Displace PPARα/LXRα Binding to The EGFR Promoter Causing its Transrepression in Luminal Cancer Cells. Sci Rep. 2015;5:15379 pubmed publisher
    ..Since other genes considered (β-catenin, cyclin D3, PLD2 and ACOX-1) are also downregulated with a PA + PPARα combination, the transrepression appears to be a global ..
  25. Mo X, Yang C, Wang X, Burkhardt B, Li Y, Xia H, et al. F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression. PLoS ONE. 2015;10:e0117156 pubmed publisher
    ..No differences in ATGL, CPT1, ACOX1, or DGAT2 expression were observed...
  26. Xu H, Zhang Q, Wei Y, Liao Z, Liang M. Dietary methionine increased the lipid accumulation in juvenile tiger puffer Takifugu rubripes. Comp Biochem Physiol B Biochem Mol Biol. 2019;230:19-28 pubmed publisher
    ..gene such as FAS, GPAT, PPARγ, ACLY, and SCD1 was down-regulated, while the gene expression of lipolytic genes ACOX1 and HSL, as well as that of ApoB100, were up-regulated by increasing dietary Met levels...
  27. Souza C, Teixeira A, Biondo L, Silveira L, Calder P, Rosa Neto J. Palmitoleic acid reduces the inflammation in LPS-stimulated macrophages by inhibition of NF?B, independently of PPARs. Clin Exp Pharmacol Physiol. 2017;44:566-575 pubmed publisher
    ..PM increased PPAR? and reduced PPAR? gene expression in macrophages of both genotypes, and increased ACOX-1 expression in KO macrophages...
  28. Wang D, Luo Y, Myakala K, Orlicky D, Dobrinskikh E, Wang X, et al. Serelaxin improves cardiac and renal function in DOCA-salt hypertensive rats. Sci Rep. 2017;7:9793 pubmed publisher
    ..decreased lipid accumulation in kidney in part by decreasing SREBP-1c, SREBP-2, ChREBP, FATP1, HMGCoAR, and LDL receptor, and increasing Acox1 and ABCA1. In summary, serelaxin reversed DOCA-salt induced cardiac and renal dysfunction.
  29. Klein K, Thomas M, Winter S, Nussler A, Niemi M, Schwab M, et al. PPARA: a novel genetic determinant of CYP3A4 in vitro and in vivo. Clin Pharmacol Ther. 2012;91:1044-52 pubmed publisher
    ..shRNA-mediated PPARA gene knockdown in primary human hepatocytes decreased expression levels of the PPAR-α target ACOX1 and of CYP3A4 by more than 50%...
  30. Wang H, Yan T, Xie Y, Zhao M, Che Y, Zhang J, et al. Mechanism-based inhibitory and peroxisome proliferator-activated receptor α-dependent modulating effects of silybin on principal hepatic drug-metabolizing enzymes. Drug Metab Dispos. 2015;43:444-54 pubmed publisher
    ..fenofibrate, characterized with significantly repressed expression of PPARα targeting genes, including L-FABP, ACOX1, and UGT1A6...
  31. Yan G, Li X, Peng Y, Long B, Fan Q, Wang Z, et al. The Fatty Acid β-Oxidation Pathway is Activated by Leucine Deprivation in HepG2 Cells: A Comparative Proteomics Study. Sci Rep. 2017;7:1914 pubmed publisher
    ..Interestingly, several proteins involved in the fatty acid β-oxidation pathway, including ACSL1, ACADS, and ACOX1, were up-regulated by Leu deprivation...
  32. Muntyan M, Cherepanov D, Malinen A, Bloch D, Sorokin D, Severina I, et al. Cytochrome cbb3 of Thioalkalivibrio is a Na+-pumping cytochrome oxidase. Proc Natl Acad Sci U S A. 2015;112:7695-700 pubmed publisher
    ..Here, we report the discovery of the first (to our knowledge) sodium-pumping Cox (Scox), a cbb3 cytochrome from the extremely alkaliphilic bacterium Thioalkalivibrio versutus...
  33. Park H, Lawrence P, Engel M, Kothapalli K, Brenna J. Metabolic fate of docosahexaenoic acid (DHA; 22:6n-3) in human cells: direct retroconversion of DHA to eicosapentaenoic acid (20:5n-3) dominates over elongation to tetracosahexaenoic acid (24:6n-3). FEBS Lett. 2016;590:3188-94 pubmed publisher
    ..MCF7 cells abundantly expressed the mitochondrial enzymes CPT1A, ECI1, and DECR1, whereas the peroxisomal enzyme ACOX1 was abundant in HepG2 cells, thus suggesting that the initial site of 22:6n-3 oxidation depends on the cell type...
  34. Yoo H, Bradford B, Kosyk O, Shymonyak S, Uehara T, Collins L, et al. Comparative analysis of the relationship between trichloroethylene metabolism and tissue-specific toxicity among inbred mouse strains: liver effects. J Toxicol Environ Health A. 2015;78:15-31 pubmed publisher
    ..of TCA and DCA were correlated with increased transcription of peroxisome proliferator-marker genes Cyp4a10 and Acox1 but not with degree of induction in hepatocellular proliferation...
  35. Wu Y, Wu Q, Beland F, Ge P, Manjanatha M, Fang J. Differential effects of triclosan on the activation of mouse and human peroxisome proliferator-activated receptor alpha. Toxicol Lett. 2014;231:17-28 pubmed publisher
    ..Western blotting analysis showed that triclosan increased acyl-coenzyme A oxidase (ACOX1), a PPARα target, in Hepa1c1c7 cells but decreased the level in HepG2 cells...
  36. Akbar H, Grala T, Vailati Riboni M, Cardoso F, Verkerk G, McGowan J, et al. Body condition score at calving affects systemic and hepatic transcriptome indicators of inflammation and nutrient metabolism in grazing dairy cows. J Dairy Sci. 2015;98:1019-32 pubmed publisher
    ..with blood biomarkers, HBCS and MBCS had greater expression of genes associated with fatty acid oxidation (CPT1A, ACOX1), ketogenesis (HMGCS2), and hepatokines (FGF21, ANGPTL4), whereas HBCS had the lowest expression of APOB (..
  37. Fernández Galilea M, Pérez Matute P, Prieto Hontoria P, Houssier M, Burrell M, Langin D, et al. α-Lipoic acid treatment increases mitochondrial biogenesis and promotes beige adipose features in subcutaneous adipocytes from overweight/obese subjects. Biochim Biophys Acta. 2015;1851:273-81 pubmed publisher
    ..and fatty acid oxidation enzymes, Carnitine palmitoyl transferase 1 and Acyl-coenzyme A oxidase (CPT-1 and ACOX) were also observed...
  38. Zhou Z, Wang F, Ren X, Wang Y, Blanchard C. Resistant starch manipulated hyperglycemia/hyperlipidemia and related genes expression in diabetic rats. Int J Biol Macromol. 2015;75:316-21 pubmed publisher
    ..involved in glucose and lipid metabolism pathways demonstrated that the expression levels of lipid oxidation gene Acox1, glycogen synthesis genes, GS2 and GYG1, and insulin-induced genes, Insig-1 and Insig-2, were significantly up-..
  39. Liu X, Duan N, Liu C, Niu C, Liu X, Wu J. Characterization of a murine nonalcoholic steatohepatitis model induced by high fat high calorie diet plus fructose and glucose in drinking water. Lab Invest. 2018;98:1184-1199 pubmed publisher
    ..NLRP-1/3 activation were found in mice fed HFCD and HFCD-HF/G for 16 weeks, whereas gene expression of CPT-1 and ACOX-1 was down-regulated in these two groups in comparison to the controls...
  40. Roh J, Lee H, Woo S, Yoon M, Kim J, Park S, et al. Herbal composition Gambigyeongsinhwan (4) from Curcuma longa, Alnus japonica, and Massa Medicata Fermentata inhibits lipid accumulation in 3T3-L1 cells and regulates obesity in Otsuka Long-Evans Tokushima Fatty rats. J Ethnopharmacol. 2015;171:287-94 pubmed publisher
    ..individual components or curcmumin increased mRNA levels of mitochondrial (CPT-1, MCAD, and VLCAD) and peroxisomal (ACOX and thiolase) PPARα target genes...
  41. Nury T, Sghaier R, Zarrouk A, Menetrier F, Uzun T, Leoni V, et al. Induction of peroxisomal changes in oligodendrocytes treated with 7-ketocholesterol: Attenuation by α-tocopherol. Biochimie. 2018;153:181-202 pubmed publisher
    ..measured by RT-qPCR and western blotting) of ABCD1 and ABCD3 (two ATP-dependent peroxisomal transporters), and of ACOX1 and MFP2 enzymes, and lower mRNA level of DHAPAT, involved in peroxisomal β-oxidation and plasmalogen synthesis, ..
  42. Zhang X, Li K, Jones R, Bruner S, Butcher R. Structural characterization of acyl-CoA oxidases reveals a direct link between pheromone biosynthesis and metabolic state in Caenorhabditis elegans. Proc Natl Acad Sci U S A. 2016;113:10055-60 pubmed publisher
    ..Here, we determine the crystal structure of the acyl-CoA oxidase 1 (ACOX-1) homodimer and the ACOX-2 homodimer bound to its substrate...
  43. Lu Y, Xu Y, Jin F, Wu Q, Shi J, Liu J. Icariin is a PPARα activator inducing lipid metabolic gene expression in mice. Molecules. 2014;19:18179-91 pubmed publisher
    ..The mRNAs of proximal β-oxidation enzymes (Acox1, Ech1, and Ehhadh) were also increased by icariin and clofibrate...
  44. Maier M, Luks L, Baudendistel O, Wittmann V, Dietrich D. Identification of d-amino acid oxidase and propiverine interaction partners and their potential role in the propiverine-mediated nephropathy. Chem Biol Interact. 2018;281:69-80 pubmed publisher
    ..The immunofluorescence analysis revealed mislocalization of many PTS1-proteins (DAAO, CAT, MFE2, ACOX1, EHHADH) in rat renal sections, strongly suggesting that propiverine primarily binds to PTS1 proteins resulting in ..
  45. Jian X, Satizabal C, Smith A, Wittfeld K, Bis J, Smith J, et al. Exome Chip Analysis Identifies Low-Frequency and Rare Variants in MRPL38 for White Matter Hyperintensities on Brain Magnetic Resonance Imaging. Stroke. 2018;: pubmed publisher
    ..At 17q25, we confirmed the association of multiple common variants in TRIM65, FBF1, and ACOX1 (P<6×10-7)...
  46. Nakajima M, Arimatsu K, Minagawa T, Matsuda Y, Sato K, Takahashi N, et al. Brazilian propolis mitigates impaired glucose and lipid metabolism in experimental periodontitis in mice. BMC Complement Altern Med. 2016;16:329 pubmed publisher
    ..Irs1, and Sirt1), but upregulation of genes associated with lipid droplet formation and gluconeogenesis (Plin2, Acox, and G6pc). However, concomitant administration of propolis abrogated these adverse effects of P. gingivalis...
  47. McIntosh A, Atshaves B, Landrock D, Landrock K, Martin G, Storey S, et al. Liver fatty acid binding protein gene-ablation exacerbates weight gain in high-fat fed female mice. Lipids. 2013;48:435-48 pubmed publisher
    ..limiting carnitine palmitoyl acyltransferase A1, CPT1A; HMG-CoA synthase) and peroxisomal (acyl CoA oxidase 1, ACOX1) LCFA β-oxidation; (3) increased fat tissue mass (FTM) and FTM/energy intake to the greatest extent; and (4) ..
  48. Corcoran J, Winter M, Lange A, Cumming R, Owen S, Tyler C. Effects of the lipid regulating drug clofibric acid on PPARα-regulated gene transcript levels in common carp (Cyprinus carpio) at pharmacological and environmental exposure levels. Aquat Toxicol. 2015;161:127-37 pubmed publisher
    ..increased transcript levels of a number of known PPARα target genes together with increased acyl-coA oxidase (Acox1) activity, supporting stimulation of lipid metabolism pathways in carp which are known to be similarly activated ..
  49. Kim Y, Jin S, Oh S, Lee G, Pham H, Choi J, et al. Platycodon grandiflorum-derived saponin enhances exercise function, skeletal muscle protein synthesis, and mitochondrial function. Food Chem Toxicol. 2018;118:94-104 pubmed publisher
    ..eccentric exercise-induced muscle damage and mitochondrial function-related peroxisomal acyl-coenzme A oxidase (ACOX-1) and carnitine palmitoyltransferase (CPT-1) in high-fat diet-induced non-alcoholic steatohepatitis, and it ..
  50. Freitas M, Francisco T, Rodrigues T, Lismont C, Domingues P, Pinto M, et al. The peroxisomal protein import machinery displays a preference for monomeric substrates. Open Biol. 2015;5:140236 pubmed publisher
    ..with previous findings on catalase, we show that PEX5 binds newly synthesized (monomeric) acyl-CoA oxidase 1 (ACOX1) and urate oxidase (UOX), potently inhibiting their oligomerization...
  51. Song Y, Tan X, Pan Y, Zhang L, Chen Q. Fatty Acid ?-Oxidation Is Essential in Leptin-Mediated Oocytes Maturation of Yellow Catfish Pelteobagrus fulvidraco. Int J Mol Sci. 2018;19: pubmed publisher
    ..i>Acadm, Hadhb, Echsl, Hsd17b4, Acca, PPAR?, CYP8B1, ACOX1, ACBP, MAPK, RINGO, Cdc2, MEK1, IGF-1R, APC/C, Cdk2, GnRHR,..
  52. Kim S, Lee Y, Koo J. Differential expression of lipid metabolism-related proteins in different breast cancer subtypes. PLoS ONE. 2015;10:e0119473 pubmed publisher
    ..1 (PLIN1), fatty acid binding protein 4 (FABP4), carnitine palmitoyltransferase IA (CPT-1A), acyl-CoA oxidase 1 (ACOX-1), and fatty acid synthase (FASN) was performed on these microarrays...
  53. Lone J, Yun J. Honokiol exerts dual effects on browning and apoptosis of adipocytes. Pharmacol Rep. 2017;69:1357-1365 pubmed publisher
    ..Honokiol also significantly increased protein expression levels of ACOX1, CPT1, p-HSL, and p-PLIN and reduced ROS levels, suggesting its possible role in fat oxidation and lipid ..
  54. Zheng L, Feng Y, Shi Y, Zhang J, Mu Q, Qin L, et al. Intralipid decreases apolipoprotein M levels and insulin sensitivity in rats. PLoS ONE. 2014;9:e105681 pubmed publisher
    ..PPARβ/δ expression was not changed by Intralipid. Whereas the mRNA levels of Acaca, Acox1, Akt1, V-raf murine sarcoma 3611 viral oncogene homolog, G6pc, Irs2, Ldlr, Map2k1, pyruvate kinase and RBC were ..
  55. Morrison E, Reinhardt H, Leclerc H, Devries T, LeBlanc S. Effect of rumen-protected B vitamins and choline supplementation on health, production, and reproduction in transition dairy cows. J Dairy Sci. 2018;101:9016-9027 pubmed publisher
    ..The gene for acyl-CoA oxidase 1 (ACOX1) had lower mRNA abundance in RPBC with no difference between treatments for the other genes, but the expression of ..
  56. de Oliveira M, Gilglioni E, de Boer B, Runge J, de Waart D, Salgueiro C, et al. Bile acid receptor agonists INT747 and INT777 decrease oestrogen deficiency-related postmenopausal obesity and hepatic steatosis in mice. Biochim Biophys Acta. 2016;1862:2054-2062 pubmed publisher
    ..Significant changes in metabolic gene expression were found in liver (Cpt1, Acox1), muscle (Ucp3, Pdk4, Cpt1, Acox1, Fasn, Fgf21), brown adipocytes (Dio2) and white adipocytes (c/EBP?, Ppar?, ..
  57. Zeng L, Tang W, Yin J, Feng L, Li Y, Yao X, et al. Alisol A 24-Acetate Prevents Hepatic Steatosis and Metabolic Disorders in HepG2 Cells. Cell Physiol Biochem. 2016;40:453-464 pubmed
    ..ACC), fatty acid synthase (FAS), carnitine palmitoyltransferase 1 (CPT1) and acyl coenzyme A oxidase 1 (ACOX1) were detected...
  58. Zheng J, Peng C, Ai Y, Wang H, Xiao X, Li J. Docosahexaenoic Acid Ameliorates Fructose-Induced Hepatic Steatosis Involving ER Stress Response in Primary Mouse Hepatocytes. Nutrients. 2016;8: pubmed publisher
    ..by upregulating the expression of carnitine palmitoyltransferase 1A (CPT-1α) and acyl-CoA oxidase 1 (ACOX1)...
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    ..with a decreased expression of main elements involved in lipogenesis (phospho-ACC), peroxisomal ?-oxidation (ACOX1), and lipid flux/storage (Ppar?/PPAR?) in liver, which suggest a recovery of lipid homeostasis...
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    ..Pathway analysis showed that fatty acid degradation (upregulated ACAA2, CPT1A, and ACOX1), protein folding (upregulated PDIs, CALR3, LMAN1, and UBQLN1) and gluconeogenesis (upregulated ACSS1, AKR1A1, ..
  61. Mi R, Sun Y, Li J, Ma S, Wen Z, Li X, et al. Immune-related proteins detected through iTRAQ-based proteomics analysis of intestines from Apostichopus japonicus in response to tussah immunoreactive substances. Fish Shellfish Immunol. 2018;74:436-443 pubmed publisher
    ..Among these 51 proteins, 7 proteins (GLO2, ACOX, CTTN, MARK, FADD, CSTA and CASP6) related to immunity with functional annotation in sea cucumber were further ..
  62. Ebner L, Glaser A, Bräuer A, Witt M, Wree A, Rolfs A, et al. Evaluation of Two Liver Treatment Strategies in a Mouse Model of Niemann-Pick-Disease Type C1. Int J Mol Sci. 2018;19: pubmed publisher
    ..g., HMG-CoA, a decrease of lipolytic gene expression, e.g., ppar? and acox1, and a decrease of lipid transporter gene expression, e.g., acat1, abca1 and fatp2...
  63. Yu G, Cheng C, Lin S, Lee Y, Frigo D, Yu Lee L, et al. Organelle-Derived Acetyl-CoA Promotes Prostate Cancer Cell Survival, Migration, and Metastasis via Activation of Calmodulin Kinase II. Cancer Res. 2018;78:2490-2502 pubmed publisher
    ..Genetic deletion of the β-oxidation rate-limiting enzyme ACOX family proteins decreased CaMKII activation, whereas overexpression of ACOXI increased CaMKII activation...
  64. Yoon S, Kim J, Lee H, Lee H, Lim J, Yang H, et al. The effects of herbal composition Gambigyeongsinhwan (4) on hepatic steatosis and inflammation in Otsuka Long-Evans Tokushima fatty rats and HepG2 cells. J Ethnopharmacol. 2017;195:204-213 pubmed publisher
    ..GGH(4) increased mRNA levels of fatty acid oxidation enzymes (ACOX, HD, CPT-1, and MCAD) and decreased mRNA levels of lipogenesis genes (FAS, ACC1, C/EBP?, and SREBP-1c) in the liver ..
  65. Xu T, Seyfert H, Shen X. Epigenetic mechanisms contribute to decrease stearoyl-CoA desaturase 1 expression in the liver of dairy cows after prolonged feeding of high-concentrate diet. J Dairy Sci. 2018;101:2506-2518 pubmed publisher
    ..formation (DGAT1 and PLIN2) were downregulated during SARA, whereas those of catabolic genes (CPT1A, CPT2, and ACOX1) and some inflammatory genes were upregulated...
  66. Patel V, Joharapurkar A, Kshirsagar S, Sutariya B, Patel M, Patel H, et al. Central administration of coagonist of GLP-1 and glucagon receptors improves dyslipidemia. Biomed Pharmacother. 2018;98:364-371 pubmed publisher
    ..Increase in the expression of LDLR, ACOX1, CPT-1, PPAR-?, CYP7A1, ABCA1 and ABCB11 was also observed in liver...
  67. Ferdinandusse S, Denis S, van Roermund C, Preece M, Koster J, Ebberink M, et al. A novel case of ACOX2 deficiency leads to recognition of a third human peroxisomal acyl-CoA oxidase. Biochim Biophys Acta Mol Basis Dis. 2018;1864:952-958 pubmed publisher
    ..Substrate specificity studies were done for ACOX1, 2 and 3 which revealed that ACOX1 is responsible for the oxidation of straight-chain fatty acids with different ..
  68. Lee H, Lee M. Coordinated regulation of scopoletin at adipose tissue-liver axis improved alcohol-induced lipid dysmetabolism and inflammation in rats. Toxicol Lett. 2015;237:210-8 pubmed publisher
    ..genes (SREBP-1c and Fasn) and increased the expression of fatty acid oxidative genes (PPARα, Acsl1, CPT, Acox, and Acaa1a) in both WAT and liver...
  69. Xie J, Chen P, Zhang J, Gao Z, Neves H, Zhang S, et al. The prognostic significance of DAPK1 in bladder cancer. PLoS ONE. 2017;12:e0175290 pubmed publisher
    ..Further analysis of the 3 independent bladder cancer datasets have identified ACOX1, UPK2, TRAK1, PLEKHG6 and MT1X genes had their expression significantly correlated with that of DAPK1...
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    ..Additionally, transcript levels of Pparα, and its targets acyl-CoA oxidase (Acox1) and hydroxy-3-methylglutaryl-CoA synthase 2 (Hmgcs2), were also downregulated, indicating changes in peroxisomal ..
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    ..expression of nuclear receptors (nr1h3, rara, rxrgb, nr1l2) and the genes associated with fatty acid oxidation (acox1, acadm, cpt1a)...
  72. Martins T, Sanglard L, Silva W, Chizzotti M, Rennó L, Serão N, et al. Molecular Factors Underlying the Deposition of Intramuscular Fat and Collagen in Skeletal Muscle of Nellore and Angus Cattle. PLoS ONE. 2015;10:e0139943 pubmed publisher
    ..were observed for mRNA expression of lipogenic and lipolytic markers ACC, FAS, FABP4, SERBP-1, CPT-2, LPL, and ACOX (P > 0.05) in skeletal muscle of Nellore and Angus cattle...
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    ..In addition, the SFA diet significantly altered the expression of 28 transcripts [e.g., acyl-CoA oxidase 1 (ACOX1) and FAT atypical cadherin 1 (FAT1)], whereas the PUFA diet did not significantly affect gene ..
  74. Plubell D, Wilmarth P, Zhao Y, Fenton A, Minnier J, Reddy A, et al. Extended Multiplexing of Tandem Mass Tags (TMT) Labeling Reveals Age and High Fat Diet Specific Proteome Changes in Mouse Epididymal Adipose Tissue. Mol Cell Proteomics. 2017;16:873-890 pubmed publisher
    ..In response to short-term high fat diet, 43 proteins representing lipid metabolism (e.g. AACS, ACOX1, ACLY) and red-ox pathways (e.g. CPD2, CYP2E, SOD3) were significantly altered (FDR < 10%)...
  75. Masson R, Guerra S, Cerini R, Pensato V, Gellera C, Taroni F, et al. Early white matter involvement in an infant carrying a novel mutation in ACOX1. Eur J Paediatr Neurol. 2016;20:431-4 pubmed publisher
    ..Molecular analysis revealed a novel ACOX1 mutation, predicting a largely truncated protein...
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    ..In this study a specific inhibitor for the rate-limiting enzyme involved in peroxisomal FAO, acyl-CoA oxidase-1 (ACOX1) was developed and used for the investigation of peroxisomal FAO inhibition upon mitochondrial FAO and ROS ..
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    ..epithelial cells, isolated from the different segments, showed also such gradient for some enzymes, ie, catalase, ACOX1, and D-specific multifunctional protein 2, and for the ABCD1 transporter, being high in small and low or absent in ..
  78. Camer D, Yu Y, Szabo A, Dinh C, Wang H, Cheng L, et al. Bardoxolone methyl prevents insulin resistance and the development of hepatic steatosis in mice fed a high-fat diet. Mol Cell Endocrinol. 2015;412:36-43 pubmed publisher
    ..fat accumulation in the liver and decreases in the β-oxidation gene, peroxisomal acyl-coenzyme A oxidase 1 (ACOX) in mice fed a HF diet...
  79. Chen X, Tian M, Sun R, Zhang M, Zhou L, Jin L, et al. SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer. EMBO Rep. 2018;19: pubmed publisher
    Peroxisomes account for ~35% of total H2O2 generation in mammalian tissues. Peroxisomal ACOX1 (acyl-CoA oxidase 1) is the first and rate-limiting enzyme in fatty acid β-oxidation and a major producer of H2
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    ..TH treatment enhanced the hepatic capacity for fatty-acid oxidation by a selective increase in hepatic Ppara, Acox, and Cd36 expression, and a decline in plasma acetyl-carnitines...
  81. Wu C, Zhang Y, Chai L, Wang H. Histological changes, lipid metabolism and oxidative stress in the liver of Bufo gargarizans exposed to cadmium concentrations. Chemosphere. 2017;179:337-346 pubmed publisher
    ..up-regulated mRNA expression of D2, SOD, GPx, ACC and FAE, but down-regulated mRNA expression of TR?, TR?, PPAR?, ACOX, CPT and SCP. However, low Cd concentration (5, 50 and 100) exposure did not cause any effect in genes expression...
  82. Li J, Huang Q, Long X, Zhang J, Huang X, Aa J, et al. CD147 reprograms fatty acid metabolism in hepatocellular carcinoma cells through Akt/mTOR/SREBP1c and P38/PPARα pathways. J Hepatol. 2015;63:1378-89 pubmed publisher
    ..peroxisome proliferator-activated receptor alpha (PPARα) and its transcriptional target genes CPT1A and ACOX1 by activating the p38 MAPK signaling pathway to inhibit fatty acid β-oxidation...
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    Acyl-coenzyme A oxidases 1 (Acox1) and 3 (Acox3) are key enzymes in the regulation of lipid homeostasis. Endogenous and exogenous factors can disrupt their normal expression/activity...
  84. Sommer J, Mahli A, Freese K, Schiergens T, Kuecuekoktay F, Teufel A, et al. Analysis of molecular mechanisms of 5-fluorouracil-induced steatosis and inflammation in vitro and in mice. Oncotarget. 2017;8:13059-13072 pubmed publisher
    ..of mitochondrial function and a dose- and time-dependently increased expression of fatty acid acyl-CoA oxidase 1 (ACOX1), which catalyzes the initial step for peroxisomal ?-oxidation...
  85. Singh H, Brogan M, Johnson D, Poulos A. Peroxisomal beta-oxidation of branched chain fatty acids in human skin fibroblasts. J Lipid Res. 1992;33:1597-605 pubmed
  86. Bouchard Mercier A, Rudkowska I, Lemieux S, Couture P, Vohl M. Polymorphisms in genes involved in fatty acid ?-oxidation interact with dietary fat intakes to modulate the plasma TG response to a fish oil supplementation. Nutrients. 2014;6:1145-63 pubmed publisher
    ..Dietary fat intakes were measured using three-day food records. SNPs within RXRA, CPT1A, ACADVL, ACAA2, ABCD2, ACOX1 and ACAA1 genes were genotyped using TAQMAN methodology...
  87. Cheng J, Liu C, Hu K, Greenberg A, Wu D, Ausman L, et al. Ablation of systemic SIRT1 activity promotes nonalcoholic fatty liver disease by affecting liver-mesenteric adipose tissue fatty acid mobilization. Biochim Biophys Acta Mol Basis Dis. 2017;1863:2783-2790 pubmed publisher
    ..Fatty acid oxidation biomarkers (acox1, acox3, cpt, ucp1, sirt3) in both liver and MAT were comparable between groups...
  88. Baumgart E, Vanhooren J, Fransen M, Marynen P, Puype M, Vandekerckhove J, et al. Molecular characterization of the human peroxisomal branched-chain acyl-CoA oxidase: cDNA cloning, chromosomal assignment, tissue distribution, and evidence for the absence of the protein in Zellweger syndrome. Proc Natl Acad Sci U S A. 1996;93:13748-53 pubmed
    ..The enzyme is encoded by a single-copy gene, which was assigned to chromosome 3p14.3 by fluorescent in situ hybridization. It was absent from livers of Zellweger patients as shown by immunoblot analysis and immunocytochemistry. ..
  89. Baarine M, Ragot K, Genin E, El Hajj H, Trompier D, Andreoletti P, et al. Peroxisomal and mitochondrial status of two murine oligodendrocytic cell lines (158N, 158JP): potential models for the study of peroxisomal disorders associated with dysmyelination processes. J Neurochem. 2009;111:119-31 pubmed publisher
    ..oligodendrocyte glycoprotein), and peroxisomal markers [adrenoleukodystrophy protein, PMP70, acyl-CoA oxidase 1 (ACOX1), l-peroxisomal bifunctional enzyme, and catalase]...
  90. Vluggens A, Andreoletti P, Viswakarma N, Jia Y, Matsumoto K, Kulik W, et al. Reversal of mouse Acyl-CoA oxidase 1 (ACOX1) null phenotype by human ACOX1b isoform [corrected]. Lab Invest. 2010;90:696-708 pubmed publisher
    Disruption of the peroxisomal acyl-CoA oxidase 1 (Acox1) gene in the mouse results in the development of severe microvesicular hepatic steatosis and sustained activation of peroxisome proliferator-activated receptor-alpha (PPARalpha)...
  91. Reinling J, Houde M, Verreault J. Environmental exposure to a major urban wastewater effluent: Effects on the energy metabolism of northern pike. Aquat Toxicol. 2017;191:131-140 pubmed publisher
    ..This exposure in male pike was associated with decreased acyl-coA oxidase (acox1) and fatty acid synthase (fasn) mRNA levels as well as a decreased acyl-coA oxidase (ACOX) activity in liver...
  92. Herzog K, Pras Raves M, Ferdinandusse S, Vervaart M, Luyf A, van Kampen A, et al. Functional characterisation of peroxisomal β-oxidation disorders in fibroblasts using lipidomics. J Inherit Metab Dis. 2018;41:479-487 pubmed publisher
    ..different defects in the β-oxidation of very long-chain fatty acids, including ABCD1- (ALD), acyl-CoA oxidase 1 (ACOX1)-, D-bifunctional protein (DBP)-, and acyl-CoA binding domain containing protein 5 (ACBD5)-deficient cell lines...