Gene Symbol: ACOT4
Description: acyl-CoA thioesterase 4
Alias: PTE-Ib, PTE1B, PTE2B, acyl-coenzyme A thioesterase 4, PTE-2b, peroxisomal acyl coenzyme A thioester hydrolase Ib, peroxisomal acyl-CoA thioesterase 2B, peroxisomal long-chain acyl-CoA thioesterase Ib
KÃ¤rst S, Arends D, Heise S, Trost J, Yaspo M, Amstislavskiy V, et al
. The direction of cross affects [corrected] obesity after puberty in male but not female offspring. BMC Genomics. 2015;16:904 pubmed publisher
..00087). Among the highest up-regulated protein coding genes in obese males were Acot4 (1.82 fold, pâ€‰=â€‰0.022), Cyp4a10 (1.35 fold, pâ€‰=â€‰0.026) and Cyp4a14 (1...
Jung S, Lee H, Hwang H, Park H, Moon Y, Kim B, et al
. Acyl-CoA thioesterase 7 is involved in cell cycle progression via regulation of PKCÎ¶-p53-p21 signaling pathway. Cell Death Dis. 2017;8:e2793 pubmed publisher
..Of the other members of the ACOT family, including ACOT1, 4, 8, 9, 11, 12, and 13 that were expressed in human, ACOT4, 8, and 12 were responsive to genotoxic stresses...
Hunt M, Nousiainen S, Huttunen M, Orii K, Svensson L, Alexson S. Peroxisome proliferator-induced long chain acyl-CoA thioesterases comprise a highly conserved novel multi-gene family involved in lipid metabolism. J Biol Chem. 1999;274:34317-26 pubmed
..These results strongly support the existence of a novel multi-gene family cluster of mouse acyl-CoA thioesterases, each with a distinct function in lipid metabolism. ..
Hunt M, Yamada J, Maltais L, Wright M, Podesta E, Alexson S. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. J Lipid Res. 2005;46:2029-32 pubmed
..The family root symbol is ACOT, with human genes named ACOT1-ACOT12, and rat and mouse genes named Acot1-Acot12. Several of the ACOT genes are the result of splicing events, and these splice variants are cataloged. ..
Hunt M, Rautanen A, Westin M, Svensson L, Alexson S. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. 2006;20:1855-64 pubmed
..However, the corresponding human gene cluster contains only three genes (ACOT1, ACOT2, and ACOT4) coding for full-length thioesterase proteins, of which only one is peroxisomal (ACOT4)...
Sherrington R, Rogaev E, Liang Y, Rogaeva E, Levesque G, Ikeda M, et al
. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 1995;375:754-60 pubmed
..Because these changes occurred in conserved domains of this gene, and are not present in normal controls, they are likely to be causative of AD3. ..
Jones J, Gould S. Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. Biochem Biophys Res Commun. 2000;275:233-40 pubmed
..The identification of PTE2 therefore offers an explanation for the observed long-chain acyl-CoA thioesterase activity of mammalian peroxisomes. ..
Westin M, Hunt M, Alexson S. The identification of a succinyl-CoA thioesterase suggests a novel pathway for succinate production in peroxisomes. J Biol Chem. 2005;280:38125-32 pubmed
..We have now expressed a peroxisomal acyl-CoA thioesterase with a previously unknown function, ACOT4, which we show is active on dicarboxylyl-CoA esters...
Auer P, Nalls M, Meschia J, Worrall B, Longstreth W, Seshadri S, et al
. Rare and Coding Region Genetic Variants Associated With Risk of Ischemic Stroke: The NHLBI Exome Sequence Project. JAMA Neurol. 2015;72:781-8 pubmed publisher
..15; P = 2.63 × 10(-8)) with an intracellular signal transduction mechanism and in ACOT4 (rs35724886; odds ratio, 2.04; P = 1...