Gene Symbol: ACOT2
Description: acyl-CoA thioesterase 2
Alias: CTE-IA, CTE1A, MTE1, PTE2, PTE2A, ZAP128, acyl-coenzyme A thioesterase 2, mitochondrial, acyl-coenzyme A thioester hydrolase 2a, long-chain acyl-CoA thioesterase 2, mitochondrial acyl-CoA thioesterase 1, peroxisomal long-chain acyl-coA thioesterase 2
Species: human
Products:     ACOT2

Top Publications

  1. Krause K, Henke C, Asiimwe T, Ulbricht A, Klemmer S, Schachtschabel D, et al. Biosynthesis and Secretion of Indole-3-Acetic Acid and Its Morphological Effects on Tricholoma vaccinum-Spruce Ectomycorrhiza. Appl Environ Microbiol. 2015;81:7003-11 pubmed publisher
    ..The export of IAA from fungal cells is supported by the multidrug and toxic extrusion (MATE) transporter Mte1 found in T. vaccinum...
  2. Yimit A, Kim T, Anand R, Meister S, Ou J, Haber J, et al. MTE1 Functions with MPH1 in Double-Strand Break Repair. Genetics. 2016;203:147-57 pubmed publisher
    ..Of particular interest, Ygr042w/Mte1, a protein of unknown function, showed robust colocalization with Rad52...
  3. Silva S, Altmannova V, Luke Glaser S, Henriksen P, Gallina I, Yang X, et al. Mte1 interacts with Mph1 and promotes crossover recombination and telomere maintenance. Genes Dev. 2016;30:700-17 pubmed publisher
    ..Here, we identify Mte1 as a novel interactor of the Mph1 helicase in Saccharomyces cerevisiae...
  4. Liu H, Zhang H, Cui R, Guo X, Wang D, Dai J. Activation of peroxisome proliferator-activated receptor α ameliorates perfluorododecanoic acid-induced production of reactive oxygen species in rat liver. Arch Toxicol. 2016;90:1383-97 pubmed publisher
    ..Among them, six significantly changed proteins (CTE1, MTE1, HADHA, ECH1, ALDH2 and CPS1) were found to be regulated by peroxisome proliferator-activated receptor alpha (PPARÎ..
  5. Xue X, Papusha A, Choi K, Bonner J, Kumar S, Niu H, et al. Differential regulation of the anti-crossover and replication fork regression activities of Mph1 by Mte1. Genes Dev. 2016;30:687-99 pubmed publisher
    We identified Mte1 (Mph1-associated telomere maintenance protein 1) as a multifunctional regulator of Saccharomyces cerevisiae Mph1, a member of the FANCM family of DNA motor proteins important for DNA replication fork repair and ..
  6. Basoli V, Santaniello S, Cruciani S, Ginesu G, Cossu M, Delitala A, et al. Melatonin and Vitamin D Interfere with the Adipogenic Fate of Adipose-Derived Stem Cells. Int J Mol Sci. 2017;18: pubmed publisher
    ..and that of adipocyte-specific genes, including lipoprotein lipase (LPL) and acyl-CoA thioesterase 2 (ACOT2), was significantly inhibited in cells that had been treated in the presence of melatonin and vitamin D, alone ..
  7. Hunt M, Yamada J, Maltais L, Wright M, Podesta E, Alexson S. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. J Lipid Res. 2005;46:2029-32 pubmed
    ..The family root symbol is ACOT, with human genes named ACOT1-ACOT12, and rat and mouse genes named Acot1-Acot12. Several of the ACOT genes are the result of splicing events, and these splice variants are cataloged. ..
  8. Sherrington R, Rogaev E, Liang Y, Rogaeva E, Levesque G, Ikeda M, et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature. 1995;375:754-60 pubmed
    ..Because these changes occurred in conserved domains of this gene, and are not present in normal controls, they are likely to be causative of AD3. ..
  9. Jones J, Gould S. Identification of PTE2, a human peroxisomal long-chain acyl-CoA thioesterase. Biochem Biophys Res Commun. 2000;275:233-40 pubmed
    Computer-based approaches identified PTE2 as a candidate human peroxisomal acyl-CoA thioesterase gene...

More Information


  1. Westin M, Alexson S, Hunt M. Molecular cloning and characterization of two mouse peroxisome proliferator-activated receptor alpha (PPARalpha)-regulated peroxisomal acyl-CoA thioesterases. J Biol Chem. 2004;279:21841-8 pubmed
    ..These data show that PTE-Ia and PTE-Ic have different functions based on different substrate specificities and tissue expression. ..
  2. Hunt M, Rautanen A, Westin M, Svensson L, Alexson S. Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs. FASEB J. 2006;20:1855-64 pubmed
    ..arose by gene duplications encoding acyl-CoA thioesterases with localizations in cytosol (ACOT1), mitochondria (ACOT2), and peroxisomes (ACOT3-6)...
  3. Mandel C, Tweel B, Tong L. Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2). Biochem Biophys Res Commun. 2009;385:630-3 pubmed publisher
    ..We report here the crystal structure at 2.1A resolution of human mitochondrial ACOT2, a type I enzyme. The structure contains two domains, N and C domains...