Gene Symbol: ACOT12
Description: acyl-CoA thioesterase 12
Alias: CACH-1, Cach, STARD15, THEAL, acyl-coenzyme A thioesterase 12, START domain-containing protein 15, StAR-related lipid transfer (START) domain containing 15, acyl-CoA thioester hydrolase 12, cytoplasmic acetyl-CoA hydrolase 1, cytosolic acetyl-CoA hydrolase, hCACH-1
Species: human
Products:     ACOT12

Top Publications

  1. Lu M, Zhu W, Wang X, Tang J, Zhang K, Yu G, et al. ACOT12-Dependent Alteration of Acetyl-CoA Drives Hepatocellular Carcinoma Metastasis by Epigenetic Induction of Epithelial-Mesenchymal Transition. Cell Metab. 2019;: pubmed publisher
    ..In this study, we identify acyl-CoA thioesterase 12 (ACOT12) as a key player in hepatocellular carcinoma (HCC) metastasis...
  2. Takano K, Tsuyusaki Y, Sato M, Takagi M, Anzai R, Okuda M, et al. A Japanese girl with an early-infantile onset vanishing white matter disease resembling Cree leukoencephalopathy. Brain Dev. 2015;37:638-42 pubmed publisher
    Vanishing white matter disease (VWM)/childhood ataxia with central hypomyelination (CACH) is an autosomal recessive leukoencephalopathy caused by mutations in one of five genes, EIF2B1-5, encoding the 5 subunits of eukaryotic translation ..
  3. Jennings M, Pavitt G. A new function and complexity for protein translation initiation factor eIF2B. Cell Cycle. 2014;13:2660-5 pubmed publisher
    ..with Vanishing White Matter (VWM), also called Childhood Ataxia with Central nervous system Hypomyelination (CACH)...
  4. Kuhle B, Eulig N, Ficner R. Architecture of the eIF2B regulatory subcomplex and its implications for the regulation of guanine nucleotide exchange on eIF2. Nucleic Acids Res. 2015;43:9994-10014 pubmed publisher
    ..that is consistent with previous biochemical and genetic data and provides a framework to better understand eIF2B function, the molecular basis for Gcn(-), Gcd(-) and VWM/CACH mutations and the evolutionary history of the eIF2B complex.
  5. Spagna A, Martella D, Fuentes L, Marotta A, Casagrande M. Hemispheric modulations of the attentional networks. Brain Cogn. 2016;108:73-80 pubmed publisher
    ..In this study, two lateralized versions of this test (LANT) were used to investigate theal effects on the attentional networks under different conflict conditions...
  6. Ferreira M, Dorboz I, Boespflug Tanguy O. Efficient detection of frequent eIF2B mutations for the rapid molecular diagnosis of CACH/VWM syndrome. Clin Biochem. 2015;48:1317-23 pubmed publisher
    ..and cost-effective molecular diagnostic assay allowing widespread routine investigation of eIF2B-related disorders (CACH/VWM syndrome)...
  7. Fang X, Zhao Z, Jiang P, Yu H, Xiao H, Yang R. Identification of the bovine HSL gene expression profiles and its association with fatty acid composition and fat deposition traits. Meat Sci. 2017;131:107-118 pubmed publisher
    ..CPT1B/CPT1C and other lipocatabolic genes were upregulated, and lipogenesis-related genes (FASN, LPL and ACOT12) were downregulated by HSL overexpression in BFFs...
  8. Hunt M, Yamada J, Maltais L, Wright M, Podesta E, Alexson S. A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases. J Lipid Res. 2005;46:2029-32 pubmed
    ..The family root symbol is ACOT, with human genes named ACOT1-ACOT12, and rat and mouse genes named Acot1-Acot12...
  9. Swarbrick C, Roman N, Cowieson N, Patterson E, Nanson J, Siponen M, et al. Structural basis for regulation of the human acetyl-CoA thioesterase 12 and interactions with the steroidogenic acute regulatory protein-related lipid transfer (START) domain. J Biol Chem. 2014;289:24263-74 pubmed publisher
    ..b>ACOT12, the primary acetyl-CoA thioesterase in the liver of human, mouse, and rat, is responsible for cleavage of the ..

More Information


  1. Suematsu N, Okamoto K, Isohashi F. Simple and unique purification by size-exclusion chromatography for an oligomeric enzyme, rat liver cytosolic acetyl-coenzyme A hydrolase. J Chromatogr B Analyt Technol Biomed Life Sci. 2003;790:239-44 pubmed
    ..33), allowing us to purify the enzyme in high purity. This strategy provides an excellent model for purifying many other oligomeric proteins including key enzymes or allosteric enzymes regulating metabolism. ..
  2. Suematsu N, Isohashi F. Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase. Acta Biochim Pol. 2006;53:553-61 pubmed
    A cDNA encoding human cytosolic acetyl-CoA hydrolase (CACH) was isolated from a human liver cDNA library, sequenced and functionally expressed in insect cells. The human CACH cDNA encodes a 555-amino-acid sequence that is 81.4%/78...
  3. Ludwig K, Mangold E, Herms S, Nowak S, Reutter H, Paul A, et al. Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci. Nat Genet. 2012;44:968-71 pubmed publisher
    ..51 × 10(-11); homozygote relative risk = 2.41, 95% confidence interval (CI) 1.84-3.16). ..
  4. Suematsu N, Okamoto K, Shibata K, Nakanishi Y, Isohashi F. Molecular cloning and functional expression of rat liver cytosolic acetyl-CoA hydrolase. Eur J Biochem. 2001;268:2700-9 pubmed
    A cytosolic acetyl-CoA hydrolase (CACH) was purified from rat liver to homogeneity by a new method using Triton X-100 as a stabilizer...
  5. Steinbacher M, Pfleger A, Schwantzer G, Jauk S, Weinhandl E, Eber E. Small airway function before and after cold dry air challenge in pediatric asthma patients during remission. Pediatr Pulmonol. 2017;52:873-879 pubmed publisher
    We wanted to compare cold dry air challenge (CACh) induced changes in spirometric parameters with changes in nitrogen multiple breath washout (N2 MBW) parameters in pediatric asthma patients during clinical remission over the ..
  6. Notarnicola A, Maccagnano G, Rifino F, Pesce V, Gallone M, Covelli I, et al. Short-term effect of shockwave therapy, temperature controlled high energy adjustable multi-mode emission laser or stretching in Dupuytren’s disease: a prospective randomized clinical trial. J Biol Regul Homeost Agents. 2017;31:775-784 pubmed
    ..SW) and high energy laser therapy [Temperature controlled High Energy Adjustable multi-mode emission Laser (THEAL)]. We recruited 45 patients, 32 males and 13 females (average age 63...
  7. Khandokar Y, Srivastava P, Cowieson N, Sarker S, Aragao D, Das S, et al. Structural insights into GDP-mediated regulation of a bacterial acyl-CoA thioesterase. J Biol Chem. 2017;292:20461-20471 pubmed publisher
    ..This is the first report of a bacterial GDP-regulated thioesterase and of covalent linkage of thioesterase domains through a disulfide bond, revealing structural similarities with ADP regulation in the human ACOT12 thioesterase.