ACO2

Summary

Gene Symbol: ACO2
Description: aconitase 2
Alias: ACONM, HEL-S-284, ICRD, OCA8, OPA9, aconitate hydratase, mitochondrial, aconitase 2, mitochondrial, citrate hydro-lyase, epididymis secretory sperm binding protein Li 284, mitochondrial aconitase
Species: human
Products:     ACO2

Top Publications

  1. Krokker L, Nyiro G, Reiniger L, Darvasi O, Szucs N, Czirjak S, et al. Differentially Expressed miRNAs Influence Metabolic Processes in Pituitary Oncocytoma. Neurochem Res. 2019;: pubmed publisher
    ..b>ACO2 and miR-744-5p interaction was validated by luciferase assay...
  2. Safonova О, Popova T, Shestakova T. Effect of 4-Methyl-Phenyl Biguanide on Free Radical Homeostasis and Activity of Oxidative Metabolism Enzymes in Rats with Cardiovascular Pathology Developing against the Background of Rheumatoid Arthritis. Bull Exp Biol Med. 2019;166:606-609 pubmed publisher
    ..Normalization of the studied parameters under the influence of the test compound in animals with experimental pathology attests to its positive effects on metabolic and free radical processes. ..
  3. Schellingen K, Van Der Straeten D, Vandenbussche F, Prinsen E, Remans T, Vangronsveld J, et al. Cadmium-induced ethylene production and responses in Arabidopsis thaliana rely on ACS2 and ACS6 gene expression. BMC Plant Biol. 2014;14:214 pubmed publisher
    ..enhanced levels of the ethylene precursor ACC together with higher mRNA levels of ethylene responsive genes: ACO2, ETR2 and ERF1 also indicated increased ethylene production in hydroponic culture...
  4. Terol J, Soler G, Talon M, Cercos M. The aconitate hydratase family from Citrus. BMC Plant Biol. 2010;10:222 pubmed publisher
    ..Two exceptions to this general observation suggest the occurrence of additional regulatory steps of citrate homeostasis in citrus. ..
  5. Guo J, Xing H, Chen M, Wang W, Zhang H, Xu S. H2S inhalation-induced energy metabolism disturbance is involved in LPS mediated hepatocyte apoptosis through mitochondrial pathway. Sci Total Environ. 2019;663:380-386 pubmed publisher
    ..metabolism-related genes (AMP-activated protein kinase (AMPK), Hypoxia-inducible factor-1 (HIF-1), aconitase 2 (ACO2), hexokinase1 (HK1), hexokinase 2 (HK2), lactate dehydrogenase A (LDHA), lactate dehydrogenase B (LDHB), ..
  6. Sekeli R, Abdullah J, Namasivayam P, Muda P, Abu Bakar U, Yeong W, et al. RNA interference of 1-aminocyclopropane-1-carboxylic acid oxidase (ACO1 and ACO2) genes expression prolongs the shelf life of Eksotika (Carica papaya L.) papaya fruit. Molecules. 2014;19:8350-62 pubmed publisher
    ..of a total of 31 putative transgenic lines planted showed a knockdown expression of the targeted ACO1 and ACO2 genes in 13 lines, which required more than 8 days to achieve the full yellow colour (Index 6)...
  7. Arya A, Bhadada S, Singh P, Dahiya D, Kaur G, Sharma S, et al. Quantitative proteomics analysis of sporadic parathyroid adenoma tissue samples. J Endocrinol Invest. 2019;42:577-590 pubmed publisher
    ..Western blot and qRT-PCR analysis of three proteins (DNAJC2, ACO2, and PRDX2) validated the LC-MS/MS findings...
  8. Ampawong S, Isarangkul D, Reamtong O, Aramwit P. Adaptive effect of sericin on hepatic mitochondrial conformation through its regulation of apoptosis, autophagy and energy maintenance: a proteomics approach. Sci Rep. 2018;8:14943 pubmed publisher
  9. Ge L, Sun Y, Ouyang F, Wu J, Ge F. The effects of triazophos applied to transgenic Bt rice on the nutritional indexes, Nlvg expression, and population growth of Nilaparvata lugens Stål under elevated CO₂. Pestic Biochem Physiol. 2015;118:50-7 pubmed publisher
    ..females in TT51 treated with 40 ppm triazophos under eCO2 was significantly higher than under ambient CO2 (aCO2) and was also higher than that in females feeding on the non-transgenic parent (MH63) under aCO2 at different days ..

More Information

Publications94

  1. Palombo V, Milanesi M, Sgorlon S, Capomaccio S, Mele M, Nicolazzi E, et al. Genome-wide association study of milk fatty acid composition in Italian Simmental and Italian Holstein cows using single nucleotide polymorphism arrays. J Dairy Sci. 2018;101:11004-11019 pubmed publisher
    ..Highlighted genes related to FA profile include ECI2, PCYT2, DCXR, G6PC3, PYCR1, and ALG12 in IS, and CYP17A1, ACO2, PI4K2A, GOT1, GPT, NT5C2, PDE6G, POLR3H, and COX15 in IH...
  2. Ospina Tascón G, Umaña M, Bermúdez W, Bautista Rincón D, Hernandez G, Bruhn A, et al. Combination of arterial lactate levels and venous-arterial CO2 to arterial-venous O 2 content difference ratio as markers of resuscitation in patients with septic shock. Intensive Care Med. 2015;41:796-805 pubmed publisher
    To evaluate the prognostic value of the Cv-aCO2/Da-vO2 ratio combined with lactate levels during the early phases of resuscitation in septic shock. Prospective observational study in a 60-bed mixed ICU...
  3. Wang L, He F, Huang Y, He J, Yang S, Zeng J, et al. Genome of Wild Mandarin and Domestication History of Mandarin. Mol Plant. 2018;11:1024-1037 pubmed publisher
    ..This study provides concrete genetic evidence for the geographical origin of extant wild mandarin populations and sheds light on the domestication and evolutionary history of mandarin. ..
  4. Warren J, Jensen A, Medlyn B, Norby R, Tissue D. Carbon dioxide stimulation of photosynthesis in Liquidambar styraciflua is not sustained during a 12-year field experiment. AoB Plants. 2014;7: pubmed publisher
    ..In 1999, Asat for eCO2 treatments was 15.4 ± 0.8 μmol m(-2) s(-1), 22 % higher than aCO2 treatments (P < 0.01)...
  5. Mizushima S, Hiyama G, Shiba K, Inaba K, Dohra H, Ono T, et al. The birth of quail chicks after intracytoplasmic sperm injection. Development. 2014;141:3799-806 pubmed publisher
    ..These findings will aid our understanding of the mechanism of avian fertilization and embryo development, as well as assisting in the manipulation of the avian genome and the production of transgenic and cloned birds. ..
  6. Takaki S, Mihara T, Mizutani K, Yamaguchi O, Goto T. Evaluation of an oxygen mask-based capnometry device in subjects extubated after abdominal surgery. Respir Care. 2015;60:705-10 pubmed publisher
    ..Furthermore, we investigated whether spontaneous deep breathing affected dissociation between P(aCO2) and P(ETCO2). Adult post-abdominal surgery subjects admitted to the ICU were enrolled in this study...
  7. Cheng C, Chen P, Chen C, Wang S, Chen C, Lee Y, et al. Differential protein expression in chicken spermatozoa before and after freezing-thawing treatment. Anim Reprod Sci. 2015;152:99-107 pubmed publisher
    ..The differing levels of these proteins could be valuable for further enhancing the fertility of frozen-thawed chicken spermatozoa. ..
  8. Tsuboi T, Oga T, Sumi K, Machida K, Ohi M, Chin K. The importance of controlling PaCOâ‚‚ throughout long-term noninvasive ventilation. Respir Care. 2014;59:1671-8 pubmed publisher
    The significance of changes in P(aCO2) during long-term noninvasive ventilation (NIV) on prognosis remains unclear. We aimed to clarify whether stabilizing P(aCO2) during NIV had a favorable prognostic effect...
  9. Ji J, Yue J, Xie T, Chen W, Du C, Chang E, et al. Roles of γ-aminobutyric acid on salinity-responsive genes at transcriptomic level in poplar: involving in abscisic acid and ethylene-signalling pathways. Planta. 2018;248:675-690 pubmed publisher
    ..pathways showed that ABA metabolic genes (ABAG, ABAH2, and ABAH4), ethylene biosynthetic genes (ACO1, ACO2, ACO5, ACOH1, ACS1, and ACS7) and receptor genes (PYL1, PYL2, PYL4, and PYL6) were regulated by exogenous GABA, ..
  10. Vincent L, Kerr S, Tan Y, Tomberg J, Raterman E, Dunning Hotopp J, et al. In Vivo-Selected Compensatory Mutations Restore the Fitness Cost of Mosaic penA Alleles That Confer Ceftriaxone Resistance in Neisseria gonorrhoeae. MBio. 2018;9: pubmed publisher
    ..This study also provides novel insights into gonococcal metabolism and physiology. ..
  11. He J, Tan Z, Zhang M, Guo L. [Effect of Xuebijing injection on hemodynamics and endothelial function in patients with severe sepsis: a prospective study]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2015;27:127-32 pubmed publisher
    ..central venous oxygen saturation (ScvO2), and difference in arterial-venous blood carbon dioxide pressure (Pv-aCO2) were determined for microcirculation assessment...
  12. Hyzewicz J, Tanihata J, Kuraoka M, Ito N, Miyagoe Suzuki Y, Takeda S. Low intensity training of mdx mice reduces carbonylation and increases expression levels of proteins involved in energy metabolism and muscle contraction. Free Radic Biol Med. 2015;82:122-36 pubmed publisher
    ..Potentially, these results will help to design therapies for DMD based on exercise mimicking drugs. ..
  13. Jin J, Lauricella D, Armstrong R, Sale P, Tang C. Phosphorus application and elevated CO2 enhance drought tolerance in field pea grown in a phosphorus-deficient vertisol. Ann Bot. 2015;116:975-85 pubmed publisher
    ..supplied with 15 mg P kg(-1) (deficient) or 60 mg P kg(-1) (adequate for crop growth) and exposed to ambient CO2 (aCO2; 380-400 ppm) or eCO2 (550-580 ppm). Drought treatments commenced at flowering...
  14. Kramer P, Duan J, Gaffrey M, Shukla A, Wang L, Bammler T, et al. Fatiguing contractions increase protein S-glutathionylation occupancy in mouse skeletal muscle. Redox Biol. 2018;17:367-376 pubmed publisher
    ..47%). Regulatory cysteines were significantly S-glutathionylated on mitochondrial complex I and II, GAPDH, MDH1, ACO2, and mitochondrial complex V among others...
  15. Rialp G, Raurich J, Llompart Pou J, Ayestarán I. Role of Respiratory Drive in Hyperoxia-Induced Hypercapnia in Ready-to-Wean Subjects With COPD. Respir Care. 2015;60:328-34 pubmed publisher
    ..1 s after the start of inspiratory flow (ΔP(0.1)) to change in P(aCO2) (ΔP(aCO2)), and the hypercapnic ventilatory response, defined as the ratio of change in minute volume (ΔVÌ..
  16. Xu M, He D, Teng H, Chen L, Song H, Huang Q. Physiological and proteomic analyses of coix seed aging during storage. Food Chem. 2018;260:82-89 pubmed publisher
    ..In addition, the proteins involved in the antioxidant system and resistance stimulus of coix seed were mostly up-regulated during storage. ..
  17. Jung S, Seo Y, Lee K, Lee D, Roe J. Essential function of Aco2, a fusion protein of aconitase and mitochondrial ribosomal protein bL21, in mitochondrial translation in fission yeast. FEBS Lett. 2015;589:822-8 pubmed publisher
    ..In fission yeast Schizosaccharomyces pombe, the aco2(+) gene encodes a fusion protein between aconitase and a putative mitochondrial ribosomal protein bL21 (Mrpl49)...
  18. Liao C, Lin Y, Kuo C. Effect of high-fat diet on hepatic proteomics of hamsters. J Agric Food Chem. 2015;63:1869-81 pubmed publisher
    ..05). Aconitate hydratase 2 (ACO2), which catalyzes the conversion of citrate to isocitrate in TCA cycle, was down-regulated in animals of the high-..
  19. Tapryal N, Vivek G V, Mukhopadhyay C. Catecholamine stress hormones regulate cellular iron homeostasis by a posttranscriptional mechanism mediated by iron regulatory protein: implication in energy homeostasis. J Biol Chem. 2015;290:7634-46 pubmed publisher
    ..Our study further reveals that mitochondrial iron content and mitochondrial aconitase (ACO2) activity are elevated by epinephrine/norepinephrine that are blocked by the antioxidant N-acetyl ..
  20. Romanick S, Ulrich C, Schlauch K, Hostler A, Payne J, Woolsey R, et al. Obesity-mediated regulation of cardiac protein acetylation: parallel analysis of total and acetylated proteins via TMT-tagged mass spectrometry. Biosci Rep. 2018;38: pubmed publisher
    ..This network included aconitate hydratase 2 (ACO2), and dihydrolipoyl dehydrogenase (DLD), in which acetylation was significantly increased by obesity...
  21. Forde N, Bazer F, Spencer T, Lonergan P. 'Conceptualizing' the Endometrium: Identification of Conceptus-Derived Proteins During Early Pregnancy in Cattle. Biol Reprod. 2015;92:156 pubmed publisher
    ..In addition, genes that have a significant biological interaction with the proteins (ACO2, CKMT1, CSTB, EEF2, GDI1, GLB1, GPLD1, HNRNPA1, HNRNPA2B1, HNRNPF, HSPA8, HSPE1, IDH2, KRT75, LGALS3, MSN, NUTF2, ..
  22. Moreira A, Figueira E, Mestre N, Schrama D, Soares A, Freitas R, et al. Impacts of the combined exposure to seawater acidification and arsenic on the proteome of Crassostrea angulata and Crassostrea gigas. Aquat Toxicol. 2018;203:117-129 pubmed publisher
  23. Liu S, Huang Y, Wang M, Chen Q, Liu L, Xie J, et al. Effects of high-frequency oscillatory ventilation and conventional mechanical ventilation on oxygen metabolism and tissue perfusion in sheep models of acute respiratory distress syndrome. Chin Med J (Engl). 2014;127:3243-8 pubmed
    ..The hemodynamics, tissue perfusion (superior mesenteric artery blood flow, pHi, and Pg-aCO2), oxygen metabolism and respiratory mechanics were examined at baseline before saline lavage, in the ARDS model, ..
  24. Sadat R, Barca E, Masand R, Donti T, Naini A, De Vivo D, et al. Functional cellular analyses reveal energy metabolism defect and mitochondrial DNA depletion in a case of mitochondrial aconitase deficiency. Mol Genet Metab. 2016;118:28-34 pubmed publisher
    ..WES revealed compound heterozygous missense variants of uncertain significance in mitochondrial aconitase (ACO2), which encodes the TCA enzyme ACO2...
  25. Ruiz Y, Farrero E, Córdoba A, González N, Dorca J, Prats E. Transcutaneous Carbon Dioxide Monitoring in Subjects With Acute Respiratory Failure and Severe Hypercapnia. Respir Care. 2016;61:428-33 pubmed publisher
    ..However, there are conflicting findings concerning its reliability when evaluating patients with high levels of P(aCO2)...
  26. Wei X, Shen F, Hong Y, Rong W, Du L, Liu X, et al. The wheat calcium-dependent protein kinase TaCPK7-D positively regulates host resistance to sharp eyespot disease. Mol Plant Pathol. 2016;17:1252-64 pubmed publisher
    ..genes (β-1,3-glucanase, chitinase 1, defensin and TaPIE1) and an ethylene biosynthesis key gene, ACO2, were significantly suppressed in the TaCPK7-D-silenced wheat plants compared with control plants...
  27. Voronkova Y, Popova T, Agarkov A, Skulachev M. Influence of 10-(6'-Plastoquinonyl)decyltriphenylphosphonium (SkQ1) on Oxidative Status in Rats with Protamine Sulfate-Induced Hyperglycemia. Biochemistry (Mosc). 2015;80:1606-13 pubmed publisher
    ..This might be related to the ability of SkQ1 to normalize free-radical homeostasis imbalanced during hyperglycemia. ..
  28. Wan R, Chen Y, Zheng X, Su Y, Huang H. Effect of CO2 on NADH production of denitrifying microbes via inhibiting carbon source transport and its metabolism. Sci Total Environ. 2018;627:896-904 pubmed publisher
    ..This study suggests that the inhibitory effect of CO2 on NADH production in denitrifiers might deteriorate the denitrification performance in an elevated CO2 climate scenario. ..
  29. Peña C, Gonzalez R, López Grueso M, Antonio Bárcena J. Redox Regulation Of Metabolic And Signaling Pathways By Thioredoxin And Glutaredoxin In Nitric Oxide Treated Hepatoblastoma Cells. Redox Biol. 2015;5:418 pubmed publisher
    ..Caspase-3 fragment levels; caspase 3, 8 and 9 activities; antiapoptotic (Bcl-2); mitochondrial energetic (Aco2) and heme (Urod) metabolism; Glycolysis (Pkm2); and pentose phosphate pathway (Tkt)...
  30. Fang B, Zhang M, Ge K, Xing H, Ren F. α-Lactalbumin-oleic acid complex kills tumor cells by inducing excess energy metabolism but inhibiting mRNA expression of the related enzymes. J Dairy Sci. 2018;101:4853-4863 pubmed publisher
    ..Our results may help clarify the mechanism of apoptosis induced by reactive oxygen species and mitochondrial destruction. ..
  31. Xia Y, Kuan C, Chiu C, Chen X, Do Y, Huang P. Global Transcriptomic Analysis of Targeted Silencing of Two Paralogous ACC Oxidase Genes in Banana. Int J Mol Sci. 2016;17: pubmed
    ..acid (ACC) oxidase homologous genes existing in the banana genome there are two genes, Mh-ACO1 and Mh-ACO2, that participate in banana fruit ripening...
  32. Ospina Tascón G, Umaña M, Bermúdez W, Bautista Rincón D, Valencia J, Madriñán H, et al. Can venous-to-arterial carbon dioxide differences reflect microcirculatory alterations in patients with septic shock?. Intensive Care Med. 2016;42:211-21 pubmed publisher
    ..Venous-to-arterial carbon dioxide difference (Pv-aCO2) may be increased even when venous O2 saturation (SvO2) and cardiac output look normal, which could suggests ..
  33. Bamba T, Hasunuma T, Kondo A. Disruption of PHO13 improves ethanol production via the xylose isomerase pathway. AMB Express. 2016;6:4 pubmed publisher
    ..the pentose phosphate pathway (GND1, SOL3, TAL1, RKI1, and TKL1) and TCA cycle and respiratory chain (NDE1, ACO1, ACO2, SDH2, IDH1, IDH2, ATP7, ATP19, SDH4, SDH3, CMC2, and ATP15) was upregulated in the YΔGP/XK/XI strain...
  34. Angebault C, Guichet P, Talmat Amar Y, Charif M, Gerber S, Fares Taie L, et al. Recessive Mutations in RTN4IP1 Cause Isolated and Syndromic Optic Neuropathies. Am J Hum Genet. 2015;97:754-60 pubmed publisher
    ..related to retinal ganglion cell (RGC) and optic-nerve degeneration, for which only mutations in TMEM126A and ACO2 are known...
  35. Alos E, Martinez Fuentes A, Reig C, Mesejo C, Rodrigo M, Agusti M, et al. Ethylene biosynthesis and perception during ripening of loquat fruit (Eriobotrya japonica Lindl.). J Plant Physiol. 2017;210:64-71 pubmed publisher
    ..the present study we have analyzed the expression of three genes related to ethylene biosynthesis (ACS1, ACO1 and ACO2), two ethylene receptors (ERS1a and ERS1b), one signal transduction component (CTR1) and one transcription factor (..
  36. Butterly C, Armstrong R, Chen D, Tang C. Free-air CO2 enrichment (FACE) reduces the inhibitory effect of soil nitrate on N2 fixation of Pisum sativum. Ann Bot. 2016;117:177-85 pubmed publisher
    ..for 15 weeks in a Vertosol containing 5, 25, 50 or 90 mg NO3(-)-N kg(-1) under either ambient CO2 (aCO2; 390 ppm) or elevated CO2 (eCO2; 550 ppm) using free-air CO2 enrichment (SoilFACE)...
  37. Zhou F, Xu X, Wu J, Wang D, Wang J. NF-?B controls four genes encoding core enzymes of tricarboxylic acid cycle. Gene. 2017;621:12-20 pubmed publisher
    ..we found that four genes that encode core enzymes of the tricarboxylic acid (TCA) cycle, including IDH1, IDH3A, ACO2, and SUCLA2, were multiply bound by this transcription factor...
  38. Dáder B, Fereres A, Moreno A, Trebicki P. Elevated CO2 impacts bell pepper growth with consequences to Myzus persicae life history, feeding behaviour and virus transmission ability. Sci Rep. 2016;6:19120 pubmed publisher
    ..Life history and feeding behaviour of Myzus persicae were studied on pepper plants under ambient (aCO2, 400 ppm) or elevated CO2 (eCO2, 650 ppm), as well as the direct impact on plant growth and leaf chemistry...
  39. Sacoman J, Dagda R, Burnham Marusich A, Dagda R, Berninsone P. Mitochondrial O-GlcNAc Transferase (mOGT) Regulates Mitochondrial Structure, Function, and Survival in HeLa Cells. J Biol Chem. 2017;292:4499-4518 pubmed publisher
    ..Our findings suggest that mOGT is catalytically active in vivo and supports mitochondrial structure, health, and survival, whereas ncOGT predominantly regulates cellular bioenergetics. ..
  40. Wu W, Wang S, Ling W, Geng L, Zhang X, Yu L, et al. Morning breathing exercises prolong lifespan by improving hyperventilation in people living with respiratory cancer. Medicine (Baltimore). 2017;96:e5838 pubmed publisher
    ..From the 5th year onwards, significant improvements were observed in ETBHT, aCO2%, PaCO2, and PaO2 (P?=?0.028). In total, 18 trainees (40.9%) and 20 nontrainees (74...
  41. Fattal Valevski A, Eliyahu H, Fraenkel N, Elmaliach G, Hausman Kedem M, Shaag A, et al. Homozygous mutation, p.Pro304His, in IDH3A, encoding isocitrate dehydrogenase subunit is associated with severe encephalopathy in infancy. Neurogenetics. 2017;18:57-61 pubmed publisher
    ..IDH3A now joins the list of TCA cycle-related proteins, which includes ACO2, DLD, SLC25A19, FH, and succinate dehydrogenase subunits, all associated with neurological disorders.
  42. Wang L, Ye J, Ou H, Qin H, Long Y, Ke J. Triphenyltin recognition by primary structures of effector proteins and the protein network of Bacillus thuringiensis during the triphenyltin degradation process. Sci Rep. 2017;7:4133 pubmed publisher
    ..The current findings develop a new approach for investigating the interactions between proteins and target compounds. ..
  43. Yu Y, Guo M, Wei Y, Yu S, Li H, Wang Y, et al. FoxO3a confers cetuximab resistance in RAS wild-type metastatic colorectal cancer through c-Myc. Oncotarget. 2016;7:80888-80900 pubmed publisher
    ..activated the transcription of the c-Myc gene, thus participated in regulating of c-Myc downstream genes, including ACO2, LARS2, MRPL12 and PKM2 in these resistant cells...
  44. Tohyama S, Fujita J, Hishiki T, Matsuura T, Hattori F, Ohno R, et al. Glutamine Oxidation Is Indispensable for Survival of Human Pluripotent Stem Cells. Cell Metab. 2016;23:663-74 pubmed publisher
    ..hPSCs were unable to utilize pyruvate-derived citrate due to negligible expression of aconitase 2 (ACO2) and isocitrate dehydrogenase 2/3 (IDH2/3) and high expression of ATP-citrate lyase...
  45. Li J, Ruzhi Deng -, Hua X, Zhang L, Lu F, Coursey T, et al. Blueberry Component Pterostilbene Protects Corneal Epithelial Cells from Inflammation via Anti-oxidative Pathway. Sci Rep. 2016;6:19408 pubmed publisher
    ..Our findings demonstrate that PS protects human cornea from hyperosmolarity-induced inflammation and oxidative stress, suggesting protective effects of PS on dry eye. ..
  46. Deng Y, Fisher A, Fong S. Systematic analysis of intracellular mechanisms of propanol production in the engineered Thermobifida fusca B6 strain. Appl Microbiol Biotechnol. 2015;99:8089-100 pubmed publisher
    ..Both the transcriptome and the intracellular metabolome confirmed that 1-propanol was produced through succinyl-CoA, L-methylmalonyl-CoA, D-methylmalonyl-CoA, and propionyl-CoA in the B6 strain. ..
  47. Xu Z, Chen X, Jin X, Meng X, Zhou X, Fan F, et al. SILAC-based proteomic analysis reveals that salidroside antagonizes cobalt chloride-induced hypoxic effects by restoring the tricarboxylic acid cycle in cardiomyocytes. J Proteomics. 2016;130:211-20 pubmed publisher
    ..the TCA cycle and in protecting cardiomyocytes from oxidative injury via up-regulation expressions of PDHE1-B, ACO2, SUCLG1, SUCLG2 and down-regulation of MDH2...
  48. Konieczna A, Szczepańska A, Sawiuk K, Węgrzyn G, Łyżeń R. Effects of partial silencing of genes coding for enzymes involved in glycolysis and tricarboxylic acid cycle on the enterance of human fibroblasts to the S phase. BMC Cell Biol. 2015;16:16 pubmed publisher
    ..This concerned following genes: HK2, PFKM, TPI, GAPDH, ENO1, LDHA, CS1, ACO2, SUCLG2, SDHA, FH and MDH2...
  49. Huo L, Li P, Xie C, Yan C, Li J. [Mixed venous-arterial carbon dioxide difference combined with passive leg raising in guiding volume management for patients post off-pump coronary artery bypass grafting]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2017;29:353-357 pubmed publisher
    To investigate whether mixed venous-arterial carbon dioxide difference (Pv-aCO2) combined with passive leg raising (PLR) could better guide volume management for patients post off-pump coronary artery bypass grafting (OPCABG)...
  50. Lu X, Chen C, Zheng T. Metagenomic Insights into Effects of Chemical Pollutants on Microbial Community Composition and Function in Estuarine Sediments Receiving Polluted River Water. Microb Ecol. 2017;73:791-800 pubmed publisher
    ..In the estuary receiving river water from the more seriously polluted River Oujiang, the sediment bacterial community function was more severely affected. ..
  51. Mutlu A, Ozturk M, Akpinar G, Kasap M, Kanli A. Proteomics analysis of pleomorphic adenoma of the human parotid gland. Eur Arch Otorhinolaryngol. 2017;274:3183-3195 pubmed publisher
    ..This study described the differences observed in protein expression patterns of the PA and normal PG. The results may provide new insights into the pathogenesis and diagnosis of PA in human PG. 1b. ..
  52. Singh S, Reddy V. Response of carbon assimilation and chlorophyll fluorescence to soybean leaf phosphorus across CO2: Alternative electron sink, nutrient efficiency and critical concentration. J Photochem Photobiol B. 2015;151:276-84 pubmed publisher
    ..50mM) and deficient (0.10 and 0.01 mM) phosphate (P) supply under ambient and elevated CO2 (aCO2, 400 and eCO2, 800 μmol mol(-1), respectively)...
  53. Dong Z, Yu Y, Li S, Wang J, Tang S, Huang R. Abscisic Acid Antagonizes Ethylene Production through the ABI4-Mediated Transcriptional Repression of ACS4 and ACS8 in Arabidopsis. Mol Plant. 2016;9:126-135 pubmed publisher
    ..Further analyses showed that expression of the ethylene biosynthesis genes ACS4, ACS8, and ACO2 was significantly decreased in abi4-152 but increased in the knockout mutants, with partial dependence on ABA...
  54. Sparkes R, Mohandas T, Sparkes M, Shulkin J. Aconitase (E.C. 4.2.1.3) mitochondrial locus (ACONM) mapped to human chromosome 22. Cytogenet Cell Genet. 1978;22:226-7 pubmed
  55. Spiegel R, Pines O, Ta Shma A, Burak E, Shaag A, Halvardson J, et al. Infantile cerebellar-retinal degeneration associated with a mutation in mitochondrial aconitase, ACO2. Am J Hum Genet. 2012;90:518-23 pubmed publisher
    ..Homozygosity mapping followed by whole-exome sequencing disclosed a Ser112Arg mutation in ACO2, encoding mitochondrial aconitase, a component of the Krebs cycle...
  56. Hua X, Chi W, Su L, Li J, Zhang Z, Yuan X. ROS-induced Oxidative Injury involved in Pathogenesis of Fungal Keratitis via p38 MAPK Activation. Sci Rep. 2017;7:10421 pubmed publisher
  57. Metodiev M, Gerber S, Hubert L, Delahodde A, Chretien D, Gérard X, et al. Mutations in the tricarboxylic acid cycle enzyme, aconitase 2, cause either isolated or syndromic optic neuropathy with encephalopathy and cerebellar atrophy. J Med Genet. 2014;51:834-8 pubmed publisher
    ..We found homozygous or compound heterozygous missense and frameshift mutations in the gene encoding mitochondrial aconitase (ACO2), a tricarboxylic acid cycle enzyme, catalysing interconversion of citrate into isocitrate...
  58. Roldan M, Islam A, Dinh P, Leung S, McManus M. Phosphate availability regulates ethylene biosynthesis gene expression and protein accumulation in white clover (Trifolium repens L.) roots. Biosci Rep. 2016;36: pubmed publisher
    ..An increase in transcript abundance of TR-ACO1 and TR-ACO3, but not TR-ACO2, was observed after 1 h of exposure to low Pi, with a second increase in TR-ACO1 transcripts occurring ..
  59. Deng Y, Zhu Q, Yu B, Zheng M, Jin J. The effects of hypervolemic infusion on microcirculation perfusion of patients during laparoscopic colorectal surgery. Medicine (Baltimore). 2017;96:e8612 pubmed publisher
    ..The gastric mucosal-arterial carbon dioxide partial pressure (Pg-aCO2) started to decrease after T2 and rebounded after T5...
  60. Panduri V, Liu G, Surapureddi S, Kondapalli J, Soberanes S, de Souza Pinto N, et al. Role of mitochondrial hOGG1 and aconitase in oxidant-induced lung epithelial cell apoptosis. Free Radic Biol Med. 2009;47:750-9 pubmed publisher
    ..A549 cells) prevents oxidant-induced mitochondrial dysfunction and apoptosis by preserving mitochondrial aconitase. Importantly, mitochondrial alpha-hOgg1 mutants lacking 8-oxoG DNA repair activity were as effective as ..
  61. Baldwin G, Seet K, Callaghan J, Toncich G, Toh B, Moritz R, et al. Purification and partial amino acid sequence of human aconitase. Protein Seq Data Anal. 1991;4:63-7 pubmed
    ..Comparison of the human amino acid sequence data with the cDNA-deduced amino acid sequence of porcine aconitase indicated that these two proteins have 95% amino acid sequence identity within the sequenced region. ..
  62. Mirel D, Marder K, Graziano J, Freyer G, Zhao Q, Mayeux R, et al. Characterization of the human mitochondrial aconitase gene (ACO2). Gene. 1998;213:205-18 pubmed
    ..the ACO2 gene on human chromosome 22q13, which encodes the essential iron-dependent metabolic enzyme mitochondrial aconitase. We determined that the ACO2 gene comprises 18 translated exons distributed over approximately 35 ..
  63. Laiho P, Hienonen T, Mecklin J, Jarvinen H, Karhu A, Launonen V, et al. Mutation and LOH analysis of ACO2 in colorectal cancer: no evidence of biallelic genetic inactivation. J Med Genet. 2003;40:e73 pubmed
  64. Yu Z, Costello L, Feng P, Franklin R. Characterization of the mitochondrial aconitase promoter and the identification of transcription factor binding. Prostate. 2006;66:1061-9 pubmed
    ..Sp1 binding to a specific Sp1 site is required for promoter activity while other transcription factors are recruited through protein-protein interactions. ..
  65. Slaughter C, Povey S, Carritt B, Solomon E, Bobrow M. Assignment of the locus ACONM to chromosome 22. Cytogenet Cell Genet. 1978;22:223-5 pubmed
  66. Meera Khan P, Wijnen L, Pearson P. Assignment of the mitochondrial aconitase gene (ACONM) to human chromosome 22. Cytogenet Cell Genet. 1978;22:212-4 pubmed
  67. Wang P, Mai C, Wei Y, Zhao J, Hu Y, Zeng Z, et al. Decreased expression of the mitochondrial metabolic enzyme aconitase (ACO2) is associated with poor prognosis in gastric cancer. Med Oncol. 2013;30:552 pubmed
    Alterations in energy metabolism play a major role in cancer development. Aconitase (ACO2) is an essential enzyme located in the mitochondria and catalyzes the interconversion of citrate and isocitrate in the tricarboxylic acid cycle...
  68. Tsui K, Chang P, Juang H. Manganese antagonizes iron blocking mitochondrial aconitase expression in human prostate carcinoma cells. Asian J Androl. 2006;8:307-15 pubmed
    To investigate the possible role of manganese in the regulation of mitochondrial aconitase (mACON) activity human prostate carcinoma cell line PC-3 cells...
  69. Martins de Souza D, Gattaz W, Schmitt A, Maccarrone G, Hunyadi Gulyas E, Eberlin M, et al. Proteomic analysis of dorsolateral prefrontal cortex indicates the involvement of cytoskeleton, oligodendrocyte, energy metabolism and new potential markers in schizophrenia. J Psychiatr Res. 2009;43:978-86 pubmed publisher
    ..Our data not only reinforces the involvement of proteins previously implicated in schizophrenia, but also suggests new markers, providing further information to foster the comprehension of this important disease. ..
  70. Bota D, Davies K. Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nat Cell Biol. 2002;4:674-80 pubmed
    b>Mitochondrial aconitase is sensitive to oxidative inactivation and can aggregate and accumulate in many age-related disorders...
  71. Khan M, Walden W, Theil E, Goss D. Thermodynamic and Kinetic Analyses of Iron Response Element (IRE)-mRNA Binding to Iron Regulatory Protein, IRP1. Sci Rep. 2017;7:8532 pubmed publisher
    Comparison of kinetic and thermodynamic properties of IRP1 (iron regulatory protein1) binding to FRT (ferritin) and ACO2 (aconitase2) IRE-RNAs, with or without Mn2+, revealed differences specific to each IRE-RNA...
  72. Slaughter C, Hopkinson D, Harris H. The distribution and properties of aconitase isozymes in man. Ann Hum Genet. 1977;40:385-401 pubmed
  73. Juang H. Modulation of mitochondrial aconitase on the bioenergy of human prostate carcinoma cells. Mol Genet Metab. 2004;81:244-52 pubmed
    ..proposed that normal citrate-producing prostate epithelial cell become citrate-oxidizing cells, in which mitochondrial aconitase (mACON) is not limiting, providing the energy required for the onset and progression of malignancy and ..
  74. Chen C, Wu Y, Chang K. Altered Aconitase 2 Activity in Huntington's Disease Peripheral Blood Cells and Mouse Model Striatum. Int J Mol Sci. 2017;18: pubmed publisher
    ..Among those molecules, aconitase 2 (Aco2) located in the mitochondrial matrix is involved in the energy generation and susceptible to increased oxidative ..
  75. Tsui K, Chung L, Wang S, Feng T, Chang P, Juang H. Hypoxia upregulates the gene expression of mitochondrial aconitase in prostate carcinoma cells. J Mol Endocrinol. 2013;51:131-41 pubmed publisher
    ..However, the target genes of hypoxia-induced metabolic alterations in the prostate remain uncertain. Mitochondrial aconitase (mACON) (ACONM) is an enzyme that is central to carbohydrate and energy metabolism and is responsible for ..
  76. Weekes J, Morrison K, Mullen A, Wait R, Barton P, Dunn M. Hyperubiquitination of proteins in dilated cardiomyopathy. Proteomics. 2003;3:208-16 pubmed
    ..A number of these proteins were identified using affinity purification and matrix-assisted laser desorption/ionisation time-of-flight mass spectrometry. ..
  77. Kim S, Cheresh P, Williams D, Cheng Y, Ridge K, Schumacker P, et al. Mitochondria-targeted Ogg1 and aconitase-2 prevent oxidant-induced mitochondrial DNA damage in alveolar epithelial cells. J Biol Chem. 2014;289:6165-76 pubmed publisher
    ..Furthermore, mt-hOgg1 chaperoning of Aco-2 in preventing oxidant-mediated mtDNA damage and apoptosis may afford an innovative target for the molecular events underlying oxidant-induced toxicity...
  78. Klausner R, Rouault T. A double life: cytosolic aconitase as a regulatory RNA binding protein. Mol Biol Cell. 1993;4:1-5 pubmed
  79. Tang M, Liu B, Wang S, Xu Y, Han P, Li P, et al. The role of mitochondrial aconitate (ACO2) in human sperm motility. Syst Biol Reprod Med. 2014;60:251-6 pubmed publisher
    ..There is little known about the role and mechanism of mitochondrial aconitase (ACO2), which is an important regulatory enzyme of the TCA cycle, in asthenozoospermia...
  80. Mangialasche F, Baglioni M, Cecchetti R, Kivipelto M, Ruggiero C, Piobbico D, et al. Lymphocytic mitochondrial aconitase activity is reduced in Alzheimer's disease and mild cognitive impairment. J Alzheimers Dis. 2015;44:649-60 pubmed publisher
    ..b>Mitochondrial aconitase (ACO2) is a Krebs cycle enzyme sensitive to free radical-mediated damage...
  81. Tsui K, Feng T, Lin Y, Chang P, Juang H. p53 downregulates the gene expression of mitochondrial aconitase in human prostate carcinoma cells. Prostate. 2011;71:62-70 pubmed publisher
    b>Mitochondrial aconitase (mACON) is regarded as the key enzyme in citrate oxidation in human prostate epithelial cells, and its abnormal expression has been implicated in tumorigenesis of the prostate...
  82. Hirosawa M, Nagase T, Murahashi Y, Kikuno R, Ohara O. Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping. DNA Res. 2001;8:1-9 pubmed
    ..In conclusion, the mapping of ESTs derived from long cDNAs followed by sequencing of the entire cDNAs provided indispensable information for the precise annotation of genes on the genome together with ESTs derived from short cDNAs. ..
  83. Gruer M, Artymiuk P, Guest J. The aconitase family: three structural variations on a common theme. Trends Biochem Sci. 1997;22:3-6 pubmed
  84. Geurts van Kessel A, Westerveld A, de Groot P, Meera Khan P, Hagemeijer A. Regional localization of the genes coding for human ACO2, ARSA, and NAGA on chromosome 22. Cytogenet Cell Genet. 1980;28:169-72 pubmed
    The segregation of the chromosome 22 markers ACO2, ARSA, and NAGA was studied in somatic cell hybrid clones...
  85. Slaughter C, Hopkinson D, Harris H. Aconitase polymorphism in man. Ann Hum Genet. 1975;39:193-202 pubmed
    ..4. The electrophoretic patterns shown by heterozygous individuals indicate that both soluble and mitochondrial aconitase are monomeric...