ACAT2

Summary

Gene Symbol: ACAT2
Description: acetyl-CoA acetyltransferase 2
Alias: acetyl-CoA acetyltransferase, cytosolic, acetoacetyl Coenzyme A thiolase, acetyl-CoA transferase-like protein, cytosolic acetoacetyl-CoA thiolase
Species: human
Products:     ACAT2

Top Publications

  1. Ohta T, Takata K, Katsuren K, Fukuyama S. The influence of the acyl-CoA:cholesterol acyltransferase-1 gene (-77G-->A) polymorphisms on plasma lipid and apolipoprotein levels in normolipidemic and hyperlipidemic subjects. Biochim Biophys Acta. 2004;1682:56-62 pubmed
    ..77G-->A variant affects plasma HDL concentrations only in hyperlipidemic subjects. These data suggest that the intracellular FC concentration might modulate plasma HDL concentrations. ..
  2. Wang Q, Liu M, Xu L, Wu Y, Huang Y. Transcriptome analysis reveals the molecular mechanism of hepatic fat metabolism disorder caused by Muscovy duck reovirus infection. Avian Pathol. 2018;47:127-139 pubmed publisher
    ..ACADVL: acyl-CoA dehydrogenase, very long chain; ACAT: mitochondrial-like acetyl-CoA acetyltransferase A; ACAT2: acetyl-CoA acyltransferase 2; ACNAT2: acyl-coenzyme A amino acid N-acyltransferase 2-like; ACOT1: acyl-CoA ..
  3. Fic A, Mlakar S, Juvan P, Mlakar V, Marc J, Dolenc M, et al. Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S. Toxicol In Vitro. 2015;29:1060-9 pubmed publisher
    ..For BPAF and BPS, the 'isoprenoid biosynthetic process' was enriched (up-regulated genes: HMGCS1, PDSS1, ACAT2, RCE1, DHDDS). Compared to BPA, BPAF and BPS had more effects on gene expression after long-term exposure...
  4. Rogers M, Liu J, Song B, Li B, Chang C, Chang T. Acyl-CoA:cholesterol acyltransferases (ACATs/SOATs): Enzymes with multiple sterols as substrates and as activators. J Steroid Biochem Mol Biol. 2015;151:102-7 pubmed publisher
    ..In mammals, there are two ACAT genes that encode two different enzymes, ACAT1 and ACAT2. Both are allosteric enzymes that can be activated by a variety of sterols...
  5. Si Y, Wen H, Li Y, He F, Li J, Li S, et al. Liver transcriptome analysis reveals extensive transcriptional plasticity during acclimation to low salinity in Cynoglossus semilaevis. BMC Genomics. 2018;19:464 pubmed publisher
    ..Genes acat2, fdps, hmgcr, hmgcs1, mvk, pmvk, ebp, lss, dhcr7, and dhcr24 were up-regulated and abat, ddc, acy1 were down-..
  6. Gordts P, Foley E, Lawrence R, Sinha R, Lameda Diaz C, Deng L, et al. Reducing macrophage proteoglycan sulfation increases atherosclerosis and obesity through enhanced type I interferon signaling. Cell Metab. 2014;20:813-26 pubmed publisher
    ..sulfate resulted in enhanced chemokine expression; increased macrophages in plaques; increased expression of ACAT2, a key enzyme in cholesterol ester storage; and increased foam cell conversion...
  7. Sodhi S, Ghosh M, Song K, Sharma N, Kim J, Kim N, et al. An approach to identify SNPs in the gene encoding acetyl-CoA acetyltransferase-2 (ACAT-2) and their proposed role in metabolic processes in pig. PLoS ONE. 2014;9:e102432 pubmed publisher
    The novel liver protein acetyl-CoA acetyltransferase-2 (ACAT2) is involved in the beta-oxidation and lipid metabolism...
  8. Zhang H, Xia H, Jiang H, Mao Y, Qu K, Huang B, et al. Longissimus Dorsi Muscle Transcriptomic Analysis of Yunling and Chinese Simmental Cattle Differing in Intramuscular Fat Content and Fatty Acid Composition. Genome. 2018;: pubmed publisher
    ..Yunling cattle showed a higher expression of lipolysis genes (ALDH9A1, ACSL5, ACADM, ACAT2, ACOT2) and a lower expression of genes related to glycometabolism (PGM1, GALM, PGM1, GPI, LDHA)...
  9. Lopez A, Posey K, Turley S. Deletion of sterol O-acyltransferase 2 (SOAT2) function in mice deficient in lysosomal acid lipase (LAL) dramatically reduces esterified cholesterol sequestration in the small intestine and liver. Biochem Biophys Res Commun. 2014;454:162-6 pubmed publisher
    Sterol O-acyltransferase 2 (SOAT2), also known as ACAT2, is the major cholesterol esterifying enzyme in the liver and small intestine (SI)...

More Information

Publications66

  1. Zhan Y, Zhang X, Xiong Y, Li B, Nan F. Design and synthesis of simple, yet potent and selective non-ring-A pyripyropene A-based inhibitors of acyl-coenzyme A: cholesterol acyltransferase 2 (ACAT2). Org Biomol Chem. 2016;14:747-751 pubmed publisher
    ..Representative compound (-)-3 exhibited potent activity against ACAT2 and greater selectivity for ACAT2 than for ACAT1.
  2. Nakao N, Kaneda H, Tsushima N, Tanaka M. Characterization of primary structure and post-hatching increase in chicken cytosolic acetoacetyl-coA thiolase in the liver. Poult Sci. 2016;95:1406-10 pubmed publisher
  3. Nido S, Shituleni S, Mengistu B, Liu Y, Khan A, Gan F, et al. Effects of Selenium-Enriched Probiotics on Lipid Metabolism, Antioxidative Status, Histopathological Lesions, and Related Gene Expression in Mice Fed a High-Fat Diet. Biol Trace Elem Res. 2016;171:399-409 pubmed publisher
    ..palmitoyltransferase-I (CPT1), carnitine palmitoyltransferase II (CPT2), acetyl-CoA acetyltransferase II (ACAT2), acyl-coenzyme A oxidase (ACOX2), and peroxisome proliferator-activated receptor alpha (PPARα) and down-..
  4. Wang L, Zhu H, Zhao Y, Jiao R, Lei L, Chen J, et al. Cranberry anthocyanin as an herbal medicine lowers plasma cholesterol by increasing excretion of fecal sterols. Phytomedicine. 2018;38:98-106 pubmed publisher
    ..on the mRNA levels of intestinal Niemann-Pick C1 like 1 protein (NPC1L1), acyl CoA:cholesterol acyltransferase2 (ACAT2), microsomal triacylglycerol transport protein (MTP), and ATP binding cassette transporter 5 (ABCG5) as well as ..
  5. Ohshiro T, Ohtawa M, Nagamitsu T, Matsuda D, Yagyu H, Davis M, et al. New pyripyropene A derivatives, highly SOAT2-selective inhibitors, improve hypercholesterolemia and atherosclerosis in atherogenic mouse models. J Pharmacol Exp Ther. 2015;355:299-307 pubmed publisher
    Sterol O-acyltransferase 2 (SOAT2; also known as ACAT2) is considered as a new therapeutic target for the treatment or prevention of hypercholesterolemia and atherosclerosis...
  6. Zhao K, Chen Y, Penner G, Oba M, Guan L. Transcriptome analysis of ruminal epithelia revealed potential regulatory mechanisms involved in host adaptation to gradual high fermentable dietary transition in beef cattle. BMC Genomics. 2017;18:976 pubmed publisher
    ..ketogenesis (HMGCL) and lipid synthesis (SREBF2, FABP4) was increased in DG, while the expression of ketogenesis (ACAT2, HMGCS) and cholesterol synthesis related genes (HMGC and FDPS) were deceased in UG...
  7. Szelechowski M, Amoedo N, Obre E, Léger C, Allard L, Bonneu M, et al. Metabolic Reprogramming in Amyotrophic Lateral Sclerosis. Sci Rep. 2018;8:3953 pubmed publisher
    ..most energy-transducing enzymes, including the fatty acid oxidation (FAO) and the ketogenic components HADHA and ACAT2, respectively...
  8. Guo J, Ito S, Nguyen H, Yamamoto K, Tanoue R, Kunisue T, et al. Effects of prenatal exposure to triclosan on the liver transcriptome in chicken embryos. Toxicol Appl Pharmacol. 2018;347:23-32 pubmed publisher
    ..g. ACSL5, ELOVL2) and repress the lipolysis signaling (e.g. ABHD5, ACAT2)...
  9. Wang H, Fang Z, Meng R, Cao Y, Tanaka N, Krausz K, et al. Glycyrrhizin and glycyrrhetinic acid inhibits alpha-naphthyl isothiocyanate-induced liver injury and bile acid cycle disruption. Toxicology. 2017;386:133-142 pubmed publisher
    ..ANIT-induced liver damage and reversed the alteration of bile acid metabolites and Cyp7a1, Npc1l1, Mttp, and Acat2 mRNAs encoding bile acid transport and metabolism proteins...
  10. Jiang C, Wang Q, Wei Y, Yao N, Wu Z, Ma Y, et al. Cholesterol-lowering effects and potential mechanisms of different polar extracts from Cyclocarya paliurus leave in hyperlipidemic mice. J Ethnopharmacol. 2015;176:17-26 pubmed publisher
    ..A (HMG-CoA) reductase, cholesterol 7α-hydroxylase (CYP7A1) and acyl-CoA cholesterol acyltransferase 2 (ACAT2) in the livers of the mice were analyzed...
  11. Ashikawa Y, Nishimura Y, Okabe S, Sato Y, Yuge M, Tada T, et al. Potential protective function of the sterol regulatory element binding factor 1-fatty acid desaturase 1/2 axis in early-stage age-related macular degeneration. Heliyon. 2017;3:e00266 pubmed publisher
    ..that expression of fatty acid desaturase 1 (FADS1), FADS2, and acetyl-CoA acetyltransferase 2 (ACAT2) is increased in macular but not extramacular tissue, possibly through activation of sterol regulatory element ..
  12. Yang F, Chen G, Ma M, Qiu N, Zhu L, Li J. Fatty acids modulate the expression levels of key proteins for cholesterol absorption in Caco-2 monolayer. Lipids Health Dis. 2018;17:32 pubmed publisher
    ..human enterocytes Caco-2 cells, and on the mRNA expression levels of NPC1L1, others proteins (ABCG5, ABCG8, ABCA1, ACAT2, MTP, Caveolin 1, Annexin-2) involved in cholesterol absorption, and SREBP-1 and SREBP-2 that are responsible for ..
  13. Liu S, You L, Zhao Y, Chang X. Wild Lonicera caerulea berry polyphenol extract reduces cholesterol accumulation and enhances antioxidant capacity in vitro and in vivo. Food Res Int. 2018;107:73-83 pubmed publisher
    ..Moreover, trimethylamine N-oxide (TMAO) levels were decreased in serum (p < 0.05). NPC1L1, ACAT2, and MTP mRNA and protein expression were reduced and ABCG5/8 expression was increased (p < 0...
  14. Ning T, Cui H, Sun F, Zou J. Systemic analysis of genome-wide expression profiles identified potential therapeutic targets of demethylation drugs for glioblastoma. Gene. 2017;627:387-392 pubmed publisher
    ..Besides, network and cross analysis identified ACAT2, UFC1 and CYB5R1 as novel therapeutic targets of demethylation drugs which also confirmed by real time RT-PCR...
  15. Zhou X, Ren F, Wei H, Liu L, Shen T, Xu S, et al. Combination of berberine and evodiamine inhibits intestinal cholesterol absorption in high fat diet induced hyperlipidemic rats. Lipids Health Dis. 2017;16:239 pubmed publisher
    ..Furthermore, intestinal NPC1L1, ACAT2, and ApoB48 protein expressions were evaluated by immunohistochemical assay...
  16. Klipsic D, Landrock D, Martin G, McIntosh A, Landrock K, Mackie J, et al. Impact of SCP-2/SCP-x gene ablation and dietary cholesterol on hepatic lipid accumulation. Am J Physiol Gastrointest Liver Physiol. 2015;309:G387-99 pubmed publisher
    ..and 4) cholesteryl ester accumulation was also associated with increased acyl-CoA cholesterol acyltransferase-2 (ACAT2) in males...
  17. Stöger J, Boshuizen M, Brufau G, Gijbels M, Wolfs I, van der Velden S, et al. Deleting myeloid IL-10 receptor signalling attenuates atherosclerosis in LDLR-/- mice by altering intestinal cholesterol fluxes. Thromb Haemost. 2016;116:565-77 pubmed publisher
    ..The induction of this process was linked to impaired ACAT2-mediated esterification of liver and plasma cholesterol...
  18. Regassa A, Kiarie E, Sands J, Walsh M, Kim W, Nyachoti C. Nutritional and metabolic implications of replacing cornstarch with D-xylose in broiler chickens fed corn and soybean meal-based diet. Poult Sci. 2017;96:388-396 pubmed publisher
    ..05) the expression of pyruvate carboxylase, Acetyl Co-A acethyltransferase 2 (ACAT2), and glucose transporter 2. Xylose linearly reduced (P < 0...
  19. Li Y, Wu S. Epigallocatechin gallate suppresses hepatic cholesterol synthesis by targeting SREBP-2 through SIRT1/FOXO1 signaling pathway. Mol Cell Biochem. 2018;: pubmed publisher
    ..HMGCR, FDPS, SS, and ABCA1 expression increased, and ACAT2 expression noticeably reduced in SREBP-2+/+ transgenic rats...
  20. He X, Lu Y, Saha N, Yang H, Heng C. Acyl-CoA: cholesterol acyltransferase-2 gene polymorphisms and their association with plasma lipids and coronary artery disease risks. Hum Genet. 2005;118:393-403 pubmed
    Acyl-CoA: cholesterol acyltransferase-2 (ACAT2), an intracellular cholesterol esterification enzyme found only in the intestine and liver, has been demonstrated to be associated with hypercholesterolemia and atherosclerosis in mice...
  21. Guo D, Lu M, Hu X, Xu J, Hu G, Zhu M, et al. Low-level expression of human ACAT2 gene in monocytic cells is regulated by the C/EBP transcription factors. Acta Biochim Biophys Sin (Shanghai). 2016;48:980-989 pubmed
    ..In our previous work, we found that the high-level expression of human ACAT2 gene with the CpG hypomethylation of its whole promoter was synergistically regulated by two transcription factors ..
  22. Morel Y, Bristow J, Gitelman S, Miller W. Transcript encoded on the opposite strand of the human steroid 21-hydroxylase/complement component C4 gene locus. Proc Natl Acad Sci U S A. 1989;86:6582-6 pubmed
  23. Liang Y, Chen J, Jiao R, Peng C, Zuo Y, Lei L, et al. Cholesterol-lowering activity of sesamin is associated with down-regulation on genes of sterol transporters involved in cholesterol absorption. J Agric Food Chem. 2015;63:2963-9 pubmed publisher
    ..of mRNA of intestinal Niemann-Pick C1 like 1 protein (NPC1L1), acyl-CoA:cholesterol acyltransferase 2 (ACAT2), microsomal triacylglycerol transport protein (MTP), and ATP-binding cassette transporters subfamily G members 5 ..
  24. Rajapakse D, Peterson K, Mishra S, Wistow G. Serum starvation of ARPE-19 changes the cellular distribution of cholesterol and Fibulin3 in patterns reminiscent of age-related macular degeneration. Exp Cell Res. 2017;361:333-341 pubmed publisher
    ..associated EFEMP1/Fibulin3 (Fib3); and levels of acyl-coenzyme A (CoA): cholesterol acyltransferases (ACAT) ACAT1, ACAT2 and Apolipoprotein B (ApoB) in ARPE-19 cells cultured in serum-supplemented and serum-free media...
  25. Chen J, Li Q, Zhang Y, Yang P, Zong Y, Qu S, et al. Oleic acid decreases the expression of a cholesterol transport-related protein (NPC1L1) by the induction of endoplasmic reticulum stress in CaCo-2 cells. J Physiol Biochem. 2011;67:153-63 pubmed publisher
    ..mechanisms, the effects of OA on the expression of cholesterol transport-related proteins (NPC1L1, ABCG5/8, ACAT2, MTP) and the unfolded protein response (UPR) pathway were studied in CaCo-2 enterocytes by incubating CaCo-2 ..
  26. Guo D, Zhang X, Li Q, Qian L, Xu J, Lu M, et al. The ACAT2 expression of human leukocytes is responsible for the excretion of lipoproteins containing cholesteryl/steryl esters. Acta Biochim Biophys Sin (Shanghai). 2016;48:990-997 pubmed
    Acyl-coenzymeA:cholesterol acyltransferase 2 (ACAT2) is abundantly expressed in intestine and fetal liver of healthy human...
  27. Zhang C, Zhang R, Li Y, Liang N, Zhao Y, Zhu H, et al. Cholesterol-Lowering Activity of Tartary Buckwheat Protein. J Agric Food Chem. 2017;65:1900-1906 pubmed publisher
    ..the gene expression of intestinal Niemann-Pick C1-like protein 1 (NPC1L1), acyl CoA:cholesterol acyltransferase 2 (ACAT2), and ATP binding cassette transporters 5 and 8 (ABCG5/8) in a down trend, whereas it increased the gene ..
  28. He X, Leow K, Yang H, Heng C. Functional characterization of two single nucleotide polymorphisms of acyl-coenzyme A:cholesterol acyltransferase 2. Gene. 2015;566:236-41 pubmed publisher
    Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) plays a critical role in the formation of cholesteryl esters from cholesterol and fatty acids, and is a potential target for treating hypercholesterolemia...
  29. Song X, Fukao T, Yamaguchi S, Miyazawa S, Hashimoto T, Orii T. Molecular cloning and nucleotide sequence of complementary DNA for human hepatic cytosolic acetoacetyl-coenzyme A thiolase. Biochem Biophys Res Commun. 1994;201:478-85 pubmed
    ..The deduced amino acid sequence has a 34-57% homology with 4 other human thiolases and 4 acetoacetyl-CoA thiolases of microorganisms. ..
  30. Temel R, Lee R, Kelley K, Davis M, Shah R, Sawyer J, et al. Intestinal cholesterol absorption is substantially reduced in mice deficient in both ABCA1 and ACAT2. J Lipid Res. 2005;46:2423-31 pubmed
    ..Because of its ability to esterify cholesterol for packaging into nascent chylomicrons, ACAT2 plays an important role in cholesterol absorption...
  31. Parini P, Jiang Z, Einarsson C, Eggertsen G, Zhang S, Rudel L, et al. ACAT2 and human hepatic cholesterol metabolism: identification of important gender-related differences in normolipidemic, non-obese Chinese patients. Atherosclerosis. 2009;207:266-71 pubmed publisher
    b>ACAT2 is a major cholesterol esterification enzyme specifically expressed in hepatocytes and may control the amount of hepatic free (unesterified) cholesterol available for secretion into bile or into HDL...
  32. Matsumoto K, Fujiwara Y, Nagai R, Yoshida M, Ueda S. Expression of two isozymes of acyl-coenzyme A: cholesterol acyltransferase-1 and -2 in clear cell type renal cell carcinoma. Int J Urol. 2008;15:166-70 pubmed publisher
    ..We identified strong expression of ACAT-1 in clear cell type RCC. Upregulation of ACAT-1 leads to high ACAT enzymatic activity, which accelerates the accumulation of cholesterol ester in clear cell type RCC. ..
  33. Nguyen T, Sawyer J, Kelley K, Davis M, Kent C, Rudel L. ACAT2 and ABCG5/G8 are both required for efficient cholesterol absorption in mice: evidence from thoracic lymph duct cannulation. J Lipid Res. 2012;53:1598-609 pubmed publisher
    ..cassette transporter G5 and G8 heterodimer (G5G8), and acyl CoA:cholesterol acyltransferase 2 (ACAT2)...
  34. Bennett M, Hosking G, Smith M, Gray R, Middleton B. Biochemical investigations on a patient with a defect in cytosolic acetoacetyl-CoA thiolase, associated with mental retardation. J Inherit Metab Dis. 1984;7:125-8 pubmed
    ..This appeared to respond to intravenous hydrocortisone therapy with an apparent complete recovery. ..
  35. Masuno M, Fukao T, Song X, Yamaguchi S, Orii T, Kondo N, et al. Assignment of the human cytosolic acetoacetyl-coenzyme A thiolase (ACAT2) gene to chromosome 6q25.3-q26. Genomics. 1996;36:217-8 pubmed
  36. McCarthy J, Meyer J, Moliterno D, Newby L, Rogers W, Topol E. Evidence for substantial effect modification by gender in a large-scale genetic association study of the metabolic syndrome among coronary heart disease patients. Hum Genet. 2003;114:87-98 pubmed
    ..0003), but not males ( P=0.292). Other genes associated only in females included THBS1, ACAT2, ITGB3, F2 and SELP ( P values ranging from 0.032 to 0.002)...
  37. Kursula P, Sikkilä H, Fukao T, Kondo N, Wierenga R. High resolution crystal structures of human cytosolic thiolase (CT): a comparison of the active sites of human CT, bacterial thiolase, and bacterial KAS I. J Mol Biol. 2005;347:189-201 pubmed
    ..The second oxyanion hole is in both structures shaped by corresponding main chain peptide NH-groups. The possible importance of bound water molecules at the catalytic site of thiolase for the reaction mechanism is discussed. ..
  38. Wang Y, Bian Y, Luo J, Lu M, Xiong Y, Guo S, et al. Corrigendum: Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation. Nat Cell Biol. 2017;19:1441 pubmed publisher
    ..This corrects the article DOI: 10.1038/ncb3551...
  39. Wang Y, Bian Y, Luo J, Lu M, Xiong Y, Guo S, et al. Cholesterol and fatty acids regulate cysteine ubiquitylation of ACAT2 through competitive oxidation. Nat Cell Biol. 2017;19:808-819 pubmed publisher
    ..However, the physiological regulation of cysteine ubiquitylation is still mysterious. Here we found that ACAT2, a cellular enzyme converting cholesterol and fatty acid to cholesteryl esters, was ubiquitylated on Cys277 for ..
  40. Shan C, Elf S, Ji Q, Kang H, Zhou L, Hitosugi T, et al. Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Mol Cell. 2014;55:552-65 pubmed publisher
    ..Moreover, we identified DLAT and ACAT2 as upstream acetyltransferases of K76 and K294, respectively, and HDAC4 as the deacetylase of both sites...
  41. Locke J, Wasan K, Nelson C, Guns E, Leon C. Androgen-mediated cholesterol metabolism in LNCaP and PC-3 cell lines is regulated through two different isoforms of acyl-coenzyme A:Cholesterol Acyltransferase (ACAT). Prostate. 2008;68:20-33 pubmed
    ..There was no effect from androgen treatment on ACAT1 protein expression in theses cells; however, ACAT2 expression was induced upon R1881 treatment...
  42. Huang Y, Jin Q, Su M, Ji F, Wang N, Zhong C, et al. Leptin promotes the migration and invasion of breast cancer cells by upregulating ACAT2. Cell Oncol (Dordr). 2017;40:537-547 pubmed publisher
    ..involved in the development of breast cancer, and univariate survival analyses have shown that over-expression of ACAT2, an enzyme that is involved in the production of cholesteryl esters, may be associated with a poor prognosis...
  43. Pramfalk C, Angelin B, Eriksson M, Parini P. Cholesterol regulates ACAT2 gene expression and enzyme activity in human hepatoma cells. Biochem Biophys Res Commun. 2007;364:402-9 pubmed
    ..The two ACAT enzymes, ACAT1 and ACAT2, lack sterol regulatory elements in their promoters and have not been thought to be transcriptionally regulated by ..
  44. Zhao Z, Lü J, Han L, Wang X, Man Q, Liu S. Prognostic significance of two lipid metabolism enzymes, HADHA and ACAT2, in clear cell renal cell carcinoma. Tumour Biol. 2016;37:8121-30 pubmed publisher
    ..enzymes, hydroxyl-coenzyme A dehydrogenase, alpha subunit (HADHA) and acetyl-coenzyme A acetyltransferase 2 (ACAT2), using Western blotting analysis, then assessed the prognostic potential of HADHA and ACAT2 using ..
  45. Yao X, Wang C, Song B, Yang X, Wang Z, Qi W, et al. Two human ACAT2 mRNA variants produced by alternative splicing and coding for novel isoenzymes. Acta Biochim Biophys Sin (Shanghai). 2005;37:797-806 pubmed
    Acyl coenzyme A:cholesterol acyltransferase 2 (ACAT2) plays an important role in cholesterol absorption. Human ACAT2 is highly expressed in small intestine and fetal liver, but its expression is greatly diminished in adult liver...
  46. Zhang Z, Liu J, Xi Y, Yang R, Chen H, Li Z, et al. Two novel cis-elements involved in hepatocyte nuclear factor 4? regulation of acyl-coenzyme A:cholesterol acyltransferase 2 expression. Acta Biochim Biophys Sin (Shanghai). 2012;44:162-71 pubmed publisher
    Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) is important for cholesterol ester synthesis and secretion...
  47. Repa J, Buhman K, Farese R, Dietschy J, Turley S. ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis. Hepatology. 2004;40:1088-97 pubmed
    ..Male ACAT2(+/+) and ACAT2(-/ -) mice were fed chow containing added cholesterol (0%-0.500% w/w) for 24 days...
  48. Turley S, Valasek M, Repa J, Dietschy J. Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1. Am J Physiol Gastrointest Liver Physiol. 2010;299:G1012-22 pubmed publisher
    ..The effect of deleting these genes, particularly acyl CoA:cholesterol acyl transferase 2 (ACAT2), on cholesterol absorption and fecal sterol excretion is well documented...
  49. Hager L, Li L, Pun H, Liu L, Hossain M, Maguire G, et al. Lecithin:cholesterol acyltransferase deficiency protects against cholesterol-induced hepatic endoplasmic reticulum stress in mice. J Biol Chem. 2012;287:20755-68 pubmed publisher
    ..low ER cholesterol seen in HCD-fed Ldlr-/-xLcat-/- mice was attributable to a coordinated marked up-regulation of ACAT2 and suppressed SREBP2 processing...
  50. Song B, Qi W, Wang C, Yang J, Yang X, Lin Z, et al. Preparation of an anti-Cdx-2 antibody for analysis of different species Cdx-2 binding to acat2 promoter. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2003;35:6-12 pubmed
    ..line Caco-2 is expressed in a differentiation-dependent manner and can efficiently bind to the mouse and human acat2 (acyl-coenzyme A: cholesterol acyltransferase 2) promoter regions, suggesting that the transcriptional factor Cdx-..
  51. De Preter V, Arijs I, Windey K, Vanhove W, Vermeire S, Schuit F, et al. Impaired butyrate oxidation in ulcerative colitis is due to decreased butyrate uptake and a defect in the oxidation pathway. Inflamm Bowel Dis. 2012;18:1127-36 pubmed publisher
    ..butyrate transporter SLC16A1 and the enzymes involved in butyrate oxidation (ACSM3, ACADS, ECHS1, HSD17B10, and ACAT2) in UC and controls...
  52. Zhai S, Zhao M, Zhou C, Lu F, Zhang H, Na L, et al. The association and significance of H3K27me3 and a folate metabolic gene ACat2 in neural tube defects. Nutr J. 2016;15:95 pubmed
    To study the association between the expression of H3K27me3 and ACat2 (a folate metabolic protein), in order to elucidate the protective mechanism of folic acid (FA) in neural tube defects (NTDs)...
  53. Yamada Y, Matsuo H, Warita S, Watanabe S, Kato K, Oguri M, et al. Prediction of genetic risk for dyslipidemia. Genomics. 2007;90:551-8 pubmed
    ..test and multivariable logistic regression analysis revealed that seven polymorphisms of APOA5, APOC3, APOA1, ACAT2, and LPL were significantly associated with hypertriglyceridemia, six polymorphisms of APOA5, LIPC, and CYP3A4 ..
  54. Atshaves B, McIntosh A, Martin G, Landrock D, Payne H, Bhuvanendran S, et al. Overexpression of sterol carrier protein-2 differentially alters hepatic cholesterol accumulation in cholesterol-fed mice. J Lipid Res. 2009;50:1429-47 pubmed publisher
    ..dehydrogenase, without alteration of other proteins involved in cholesterol uptake (caveolin), esterification (ACAT2), efflux (ATP binding cassette A-1 receptor, ABCG5/8, and apolipoprotein A1), or oxidation/transport of bile salts ..
  55. Jiang Z, Jiang C, Wang L, Wang J, Zhang S, Einarsson C, et al. Increased NPC1L1 and ACAT2 expression in the jejunal mucosa from Chinese gallstone patients. Biochem Biophys Res Commun. 2009;379:49-54 pubmed publisher
    ..The intestinal mRNA expression of NPC1L1 and ACAT2 were significantly higher in GS than GSF (P<0.05)...
  56. Katsuren K, Fukuyama S, Takata K, Ohta T. Effects of a new single-nucleotide polymorphism in the Acyl-CoA:cholesterol acyltransferase-2 gene on plasma lipids and apolipoproteins in patients with hyperlipidemia. J Atheroscler Thromb. 2003;10:32-6 pubmed
    ..Although further studies are needed, our data suggest that the ACAT-2 gene may not affect lipid levels in humans. ..
  57. Lopez A, Chuang J, Turley S. Impact of loss of SOAT2 function on disease progression in the lysosomal acid lipase-deficient mouse. Steroids. 2018;130:7-14 pubmed publisher
    ..our earlier findings in young male LAL-deficient mice also missing sterol O-acyltransferase 2 (SOAT2, also called ACAT2)...