Gene Symbol: ACADS
Description: acyl-CoA dehydrogenase short chain
Alias: ACAD3, SCAD, short-chain specific acyl-CoA dehydrogenase, mitochondrial, acyl-CoA dehydrogenase, C-2 to C-3 short chain, acyl-Coenzyme A dehydrogenase, C-2 to C-3 short chain, butyryl-CoA dehydrogenase, mitochondrial short-chain specific acyl-CoA dehydrogenase, unsaturated acyl-CoA reductase
Species: human
Products:     ACADS

Top Publications

  1. Jethva R, Bennett M, Vockley J. Short-chain acyl-coenzyme A dehydrogenase deficiency. Mol Genet Metab. 2008;95:195-200 pubmed publisher
    ..The long-term consequences and the need for chronic therapy remain current topics of contention and investigation. ..
  2. Illig T, Gieger C, Zhai G, Römisch Margl W, Wang Sattler R, Prehn C, et al. A genome-wide perspective of genetic variation in human metabolism. Nat Genet. 2010;42:137-41 pubmed publisher
    ..For eight out of nine replicated loci (FADS1, ELOVL2, ACADS, ACADM, ACADL, SPTLC3, ETFDH and SLC16A9), the genetic variant is located in or near genes encoding enzymes or ..
  3. Jiang M, Liu L, Mei H, Li X, Cheng J, Cai Y. Detection of inborn errors of metabolism using GC-MS: over 3 years of experience in southern China. J Pediatr Endocrinol Metab. 2015;28:375-80 pubmed publisher
    ..Urease pretreatment is useful for the diagnosis of NICCD. In southern China, the majority of IEM were amino acid disorders and organic acid disorders. FAO disorders were relatively rare, which we need to investigate further. ..
  4. Martin G, Atshaves B, McIntosh A, Mackie J, Kier A, Schroeder F. Liver fatty acid-binding protein gene-ablated female mice exhibit increased age-dependent obesity. J Nutr. 2008;138:1859-65 pubmed
    ..The data support a working model in which obesity development in these mice results from shifts toward reduced energy expenditure and/or more efficient energy uptake in the gut. ..
  5. Nafisinia M, Menezes M, Gold W, Riley L, Hatch J, Cardinal J, et al. Tread carefully: A functional variant in the human NADPH oxidase 4 (NOX4) is not disease causing. Mol Genet Metab. 2018;123:382-387 pubmed publisher
  6. Ziosi M, Di Meo I, Kleiner G, Gao X, Barca E, Sanchez Quintero M, et al. Coenzyme Q deficiency causes impairment of the sulfide oxidation pathway. EMBO Mol Med. 2017;9:96-111 pubmed publisher
  7. Hu L, Huang H, Yuan H, Tao F, Xie H, Wang S. Rex in Clostridium kluyveri is a global redox-sensing transcriptional regulator. J Biotechnol. 2016;233:17-25 pubmed publisher
    ..These results suggest that Rex plays a key role in the carbon and energy metabolism of C. kluyveri as a global transcriptional regulator in response to the cellular NADH/NAD(+) ratio. ..
  8. Bloom K, Mohsen A, Karunanidhi A, El Demellawy D, Reyes Mugica M, Wang Y, et al. Investigating the link of ACAD10 deficiency to type 2 diabetes mellitus. J Inherit Metab Dis. 2018;41:49-57 pubmed publisher
    ..C-terminus region that is structurally similar to members of a family of flavoenzymes-the acyl-CoA dehydrogenases (ACADs)-that catalyze ?,?-dehydrogenation reactions, including the first step in mitochondrial FAO (FAO), and ..
  9. Martens J, Berden G, Bentlage H, Coene K, Engelke U, Wishart D, et al. Unraveling the unknown areas of the human metabolome: the role of infrared ion spectroscopy. J Inherit Metab Dis. 2018;41:367-377 pubmed publisher
    ..Infrared ion spectroscopy has the potential to play a pivotal role in the identification of challenging biomarkers. ..

More Information

Publications123 found, 100 shown here

  1. Schouw A, Vulcano F, Roalkvam I, Hocking W, Reeves E, Stokke R, et al. Genome Analysis of Vallitalea guaymasensis Strain L81 Isolated from a Deep-Sea Hydrothermal Vent System. Microorganisms. 2018;6: pubmed publisher
    ..This study enlightens the function of the fermentative microorganisms from hydrothermal vents systems and adds valuable information on the bioprospecting potential emerging in deep-sea hydrothermal systems. ..
  2. Yoo M, Bestel Corre G, Croux C, Rivière A, Meynial Salles I, Soucaille P. A Quantitative System-Scale Characterization of the Metabolism of Clostridium acetobutylicum. MBio. 2015;6:e01808-15 pubmed publisher
    ..This approach allows for a better understanding of the regulation of primary metabolism and for the functional characterization of numerous enzymes involved in primary metabolism. ..
  3. Chowdhury N, Kahnt J, Buckel W. Reduction of ferredoxin or oxygen by flavin-based electron bifurcation in Megasphaera elsdenii. FEBS J. 2015;282:3149-60 pubmed publisher
    ..As a result of the production of reactive oxygen species, electron bifurcation can be regarded as an Achilles' heel of anaerobes when exposed to air. ..
  4. Groeger C, Wang W, Sabra W, Utesch T, Zeng A. Metabolic and proteomic analyses of product selectivity and redox regulation in Clostridium pasteurianum grown on glycerol under varied iron availability. Microb Cell Fact. 2017;16:64 pubmed publisher
    ..Not only the NADH pool but also the regulation of the ferredoxin pool could explain such product variation under different iron conditions. ..
  5. Minkler P, Stoll M, Ingalls S, Kerner J, Hoppel C. Quantitative acylcarnitine determination by UHPLC-MS/MS--Going beyond tandem MS acylcarnitine "profiles". Mol Genet Metab. 2015;116:231-41 pubmed publisher
    ..These capabilities are unavailable when using tandem MS "profiles". We also show examples of research interest, where separation of acylcarnitine species and accurate and precise acylcarnitine quantification is necessary. ..
  6. Schmid G, René S, Boll M. Enzymes of the benzoyl-coenzyme A degradation pathway in the hyperthermophilic archaeon Ferroglobus placidus. Environ Microbiol. 2015;17:3289-300 pubmed publisher
    ..placidus and probably other archaea predominantly degrade aromatics via the Thauera/Azoarcus type and not or only to a minor extent via the predicted R. palustris-type benzoyl-CoA degradation pathway. ..
  7. Jeong J, Bertsch J, Hess V, Choi S, Choi I, Chang I, et al. Energy Conservation Model Based on Genomic and Experimental Analyses of a Carbon Monoxide-Utilizing, Butyrate-Forming Acetogen, Eubacterium limosum KIST612. Appl Environ Microbiol. 2015;81:4782-90 pubmed publisher
    ..The overall ATP yield was calculated and is significantly higher than the one obtained with H2 + CO2. The energetic benefit may be one reason that butyrate is formed only from CO but not from H2 + CO2. ..
  8. Honda K, Saneyasu T, Sugimoto H, Kurachi K, Takagi S, Kamisoyama H. Role of peroxisome proliferator-activated receptor alpha in the expression of hepatic fatty acid oxidation-related genes in chickens. Anim Sci J. 2016;87:61-6 pubmed publisher
    ..acyl-coenzyme A oxidase (ACO), but not long-, middle- and short-chain acyl-coenzyme A dehydrogenase (LCAD, MCAD and SCAD, respectively), hydroxyacyl-coenzyme A dehydrogenase (HAD), and PPARα itself in chicken hepatoma cells...
  9. Zoladz J, Koziel A, Broniarek I, Woyda Ploszczyca A, Ogrodna K, Majerczak J, et al. Effect of temperature on fatty acid metabolism in skeletal muscle mitochondria of untrained and endurance-trained rats. PLoS ONE. 2017;12:e0189456 pubmed publisher
    ..such as fatty acid transporter CD36, carnitine palmitoyltransferase 1A (CPT1A), and acyl-CoA dehydrogenase (ACADS)...
  10. Bulut F, Kor D, Seker Yilmaz B, Gul Mert G, Kılavuz S, Onenli Mungan N. Turkish case of ethylmalonic encephalopathy misdiagnosed as short chain acyl-CoA dehydrogenase deficiency. Metab Brain Dis. 2018;33:977-979 pubmed publisher
    ..Here, we describe a case of ethylmalonic encephalopathy with late onset neurologic symptoms and a confusing family history of two deceased brothers with the wrong suspicion of short chain acyl-CoA dehydrogenase deficiency. ..
  11. Meierhofer D, Halbach M, Åžen N, Gispert S, Auburger G. Ataxin-2 (Atxn2)-Knock-Out Mice Show Branched Chain Amino Acids and Fatty Acids Pathway Alterations. Mol Cell Proteomics. 2016;15:1728-39 pubmed publisher
    ..In liver tissue, significant downregulations of the proteins ACADS, ALDH6A1, ALDH7A1, IVD, MCCC2, PCCA, OTC, together with bioinformatic enrichment of downregulated pathways for ..
  12. Chai A, Bulloch E, Evans G, Lott J, Baker E, Johnston J. A covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocket. Acta Crystallogr D Biol Crystallogr. 2015;71:862-72 pubmed publisher
    ..The acyl-binding pocket adopts a different orientation (relative to the FAD) to other structurally characterized ACADs. This difference may be correlated with the apparent ability of MbtN to catalyse the formation of an unusual cis ..
  13. Meng Q, Duan X, Wang C, Liu Z, Sun P, Huo X, et al. Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation. Acta Pharmacol Sin. 2017;38:69-79 pubmed publisher
    ..hepatic levels of SREBP-1c, FAS, ACC1 and SCD1 and increased lipid metabolism via inducing PPAR?, CPT1?, ACADS and LPL...
  14. Sun X, Duan X, Wang C, Liu Z, Sun P, Huo X, et al. Protective effects of glycyrrhizic acid against non-alcoholic fatty liver disease in mice. Eur J Pharmacol. 2017;806:75-82 pubmed publisher
    ..SREBP-1c, FAS and SCD1 expression, increased fatty acids ?-oxidation via an increase in PPAR?, CPT1? and ACADS, and promoted triglyceride metabolism through inducing LPL activity...
  15. Kahles F, Schuh A, Lehrke M, Burgmaier M, Marx N, Reith S. [Non-ST-Segment Elevation Myocardial Infarction Caused by Spontaneous Coronary Thrombosis by Intimal Rupture]. Dtsch Med Wochenschr. 2017;142:1686-1689 pubmed publisher
    ..b>Conclusion?Coronary thrombosis of our patient was caused by spontaneous coronary artery dissection (SCAD). SCAD?is an important differential diagnosis in patients with ACS...
  16. Ahmad N, Wan Mahiyuddin W, Tengku Mohamad T, Ling C, Daud S, Hussein N, et al. Fish consumption pattern among adults of different ethnics in Peninsular Malaysia. Food Nutr Res. 2016;60:32697 pubmed publisher in descending order: Indian mackerel, anchovy, yellowtail and yellow-stripe scads, tuna, sardines, torpedo scad, Indian and short-fin scads, pomfret, red snapper, and king mackerel...
  17. Bhatt D, Kachru R, Gupta S, Kaul U. Recurrent chest pain after treatment of spontaneous coronary artery dissection: An enigma. Indian Heart J. 2015;67 Suppl 3:S18-20 pubmed publisher
    Spontaneous coronary artery dissection (SCAD) is a rare entity...
  18. Boynton T, SHIMKETS L. Myxococcus CsgA, Drosophila Sniffer, and human HSD10 are cardiolipin phospholipases. Genes Dev. 2015;29:1903-14 pubmed publisher
    Myxococcus xanthus development requires CsgA, a member of the short-chain alcohol dehydrogenase (SCAD) family of proteins...
  19. Wang C, Duan X, Sun X, Liu Z, Sun P, Yang X, et al. Protective effects of glycyrrhizic acid from edible botanical glycyrrhiza glabra against non-alcoholic steatohepatitis in mice. Food Funct. 2016;7:3716-23 pubmed publisher
    ..levels of SREBP-1c, FAS, ACC1 and SCD1, and increased lipid metabolism through an induction of PPAR?, CPT1?, ACADS and LPL...
  20. Li D, Yan J, Yuan Y, Wang C, Wu J, Chen Q, et al. Genome-wide DNA methylome alterations in acute coronary syndrome. Int J Mol Med. 2018;41:220-232 pubmed publisher
    ..polymerase chain reaction (MSP) and Sequenom MassARRAY analyses in ACS, stable coronary artery disease (SCAD) and control samples...
  21. Zhang S, Wang Q, Cui Y, Wu W, Zhao Q, Xu Y, et al. High-sensitivity cardiac troponin T in geriatric inpatients. Arch Gerontol Geriatr. 2016;65:111-5 pubmed publisher
    ..were no significant differences in hs-cTnT levels between geriatrics patients with stable coronary artery disease (SCAD) and those without SCAD...
  22. Tweet M, Gulati R, Hayes S. Spontaneous Coronary Artery Dissection. Curr Cardiol Rep. 2016;18:60 pubmed publisher
    ..ultrasound have enhanced the ability to visualize intimal disruption and intramural hematoma associated with SCAD. Formerly considered "rare," these technological advances and heightened awareness suggest that SCAD is more ..
  23. Song Y, Tan X, Pan Y, Zhang L, Chen Q. Fatty Acid ?-Oxidation Is Essential in Leptin-Mediated Oocytes Maturation of Yellow Catfish Pelteobagrus fulvidraco. Int J Mol Sci. 2018;19: pubmed publisher
    ..and C-Myc) and ten down-regulated gene (PPAR?, FATCD36, UBC, PDK1, Acads, Raf, Fizzy, C3H-4, Raf and PKC), involved in fatty acid ?-oxidation and ..
  24. Acena A, Pello A, Carda R, Lorenzo O, González Casaús M, Blanco Colio L, et al. Parathormone Levels Are Independently Associated with the Presence of Left Ventricular Hypertrophy in Patients with Coronary Artery Disease. J Nutr Health Aging. 2016;20:659-64 pubmed publisher
    ..LVH was measured in 146 outpatients with stable coronary artery disease (SCAD) using echocardiography...
  25. Lamhonwah A, Tein I. Novel localization of OCTN1, an organic cation/carnitine transporter, to mammalian mitochondria. Biochem Biophys Res Commun. 2006;345:1315-25 pubmed
    ..This suggests an important yet different role for OCTN1 from other OCTN family members in intracellular carnitine homeostasis. ..
  26. Anderson R, Jayadeva P, Wilson W, Iyer R. Spontaneous Coronary Artery Dissection: Case Series from a Tertiary Centre. Heart Lung Circ. 2016;25:e41-5 pubmed publisher
    Spontaneous coronary artery dissection (SCAD) is a rare cause of non-atherosclerotic acute coronary syndrome (ACS). As it is more commonly seen in young women, the diagnosis can be missed...
  27. Tan J, Chen D, Li Z, Huang J, Yan T, Cai R. [An analysis of clinical characteristics and gene mutation in two patients with medium- and short-chain acyl-CoA dehydrogenase deficiency]. Zhongguo Dang Dai Er Ke Za Zhi. 2016;18:1019-1025 pubmed
    ..2). Sanger sequencing revealed a reported c.625G>A (p.Gly209Ser) homozygous mutation in the ACADS gene...
  28. Thapa D, Zhang M, Manning J, Guimaraes D, Stoner M, O Doherty R, et al. Acetylation of mitochondrial proteins by GCN5L1 promotes enhanced fatty acid oxidation in the heart. Am J Physiol Heart Circ Physiol. 2017;313:H265-H274 pubmed publisher
    ..Here, we provide new evidence that acetylation of cardiac mitochondrial fatty acid oxidation enzymes by GCN5L1 significantly upregulates their activity in diet-induced obese mice. ..
  29. Li M, Li Y, Chen Z. Mitochondrial genome of the Torpedo scad Megalaspis cordyla (Perciformes: Carangidae): genome characterization and phylogenetic consideration. Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:1856-7 pubmed publisher
    This study presented the complete mitochondrial genome of the Torpedo scad Megalaspis cordyla, the only member of its genus, as well as its phylogenetic position in Carangidae...
  30. De Palma R, Cirillo P, Ciccarelli G, Barra G, Conte S, Pellegrino G, et al. Expression of functional tissue factor in activated T-lymphocytes in vitro and in vivo: A possible contribution of immunity to thrombosis?. Int J Cardiol. 2016;218:188-195 pubmed publisher CD3(+)-cells isolated from the aorta and the coronary sinus of ACS-NSTEMI and stable coronary artery disease (SCAD) patients...
  31. Saw J, Mancini G, Humphries K. Contemporary Review on Spontaneous Coronary Artery Dissection. J Am Coll Cardiol. 2016;68:297-312 pubmed publisher
    Spontaneous coronary artery dissection (SCAD) is gaining recognition as an important cause of myocardial infarction, especially in young women...
  32. Conrotto F, D Ascenzo F, Cerrato E, Fernández Ortiz A, Gonzalo N, Macaya F, et al. Safety and efficacy of drug eluting stents in patients with spontaneous coronary artery dissection. Int J Cardiol. 2017;238:105-109 pubmed publisher
    ..the different pathogenesis, use of drug eluting stent (DES) in patients with Spontaneous Coronary Artery Dissection SCAD may delay the healing of the dissected vessel...
  33. Wasilewski J, Poloński L, Lekston A, Osadnik T, Reguła R, Bujak K, et al. Who is eligible for randomized trials? A comparison between the exclusion criteria defined by the ISCHEMIA trial and 3102 real-world patients with stable coronary artery disease undergoing stent implantation in a single cardiology center. Trials. 2015;16:411 pubmed publisher
    ..We studied the eligibility criteria for 3102 "real-life" patients with stable coronary artery disease (SCAD) according to the ISCHEMIA (International Study of Comparative Health Effectiveness with Medical and Invasive ..
  34. Shen Z, Jiang C, Chen L. Evaluation of a train-the-trainer program for stable coronary artery disease management in community settings: A pilot study. Patient Educ Couns. 2018;101:256-265 pubmed publisher
    ..feasibility and effectiveness of conducting a train-the-trainer (TTT) program for stable coronary artery disease (SCAD) management in community settings...
  35. Abe A, Nito C, Sakamoto Y, Nogami A, Hokama H, Takahashi S, et al. Spontaneous Bilateral Cervical Internal Carotid and Vertebral Artery Dissection in a Japanese Patient without Collagen Vascular Disease with Special Reference to Single-Nucleotide Polymorphisms. J Stroke Cerebrovasc Dis. 2016;25:e114-7 pubmed publisher
    Spontaneous cervical artery dissection (sCAD) is a major cause of ischemic stroke in young adults. Frequently, sCAD involves multiple neck arteries, accounting for 13%-28% of the total sCAD cases...
  36. Main A, Prakash R, Starovoytov A, Sabbaghan A, Aymong E, Mancini G, et al. Characteristics of extension and de novo recurrent spontaneous coronary artery dissection. EuroIntervention. 2017;13:e1454-e1459 pubmed publisher
    Spontaneous coronary artery dissection (SCAD) is an under-recognised and important cause of myocardial infarction in young women. Recurrent SCAD is frequent but poorly understood...
  37. Goetzman E, He M, Nguyen T, Vockley J. Functional analysis of acyl-CoA dehydrogenase catalytic residue mutants using surface plasmon resonance and circular dichroism. Mol Genet Metab. 2006;87:233-42 pubmed
    ..We previously generated catalytic residue mutants of human short-chain acyl-CoA dehydrogenase (SCAD) and isovaleryl-CoA dehydrogenase (IVD) that were difficult to characterize by traditional methods...
  38. Chou A, Prakash R, Rajala J, Birnie T, Isserow S, Taylor C, et al. The First Dedicated Cardiac Rehabilitation Program for Patients With Spontaneous Coronary Artery Dissection: Description and Initial Results. Can J Cardiol. 2016;32:554-60 pubmed publisher
    Spontaneous coronary artery dissection (SCAD) is an important cause of myocardial infarction in women, but the role of rehabilitation after SCAD is unclear...
  39. Kempter J, Kielpinski M, Panicz R, Prüffer K, Keszka S. Development of the method for identification of selected populations of torpedo scad, Megalaspis cordyla (Linnaeus, 1758), using microsatellite DNA analyses. CELFISH project - Part 4. Food Chem. 2017;221:944-949 pubmed publisher
    Catch and consumption of torpedo scad (Megalaspis cordyla) over the western Indian Ocean, but also the western Pacific from Japan to Australia is constantly increasing...
  40. Lucas T, Henriques B, Rodrigues J, Bross P, Gregersen N, Gomes C. Cofactors and metabolites as potential stabilizers of mitochondrial acyl-CoA dehydrogenases. Biochim Biophys Acta. 2011;1812:1658-63 pubmed publisher
  41. Tokatlı A, Tatli E, Can Y, Pabuccu T. Spontaneous left main coronary artery dissection. Indian Heart J. 2016;68:184-5 pubmed publisher
    Spontaneous coronary artery dissection (SCAD) is a very rare clinical condition. Physiopathology of SCAD is still mostly unclear. Clinical presentation of SCAD ranges from atypical symptoms to sudden cardiac death...
  42. Bergström I, Lundberg A, Jonsson S, Särndahl E, Ernerudh J, Jonasson L. Annexin A1 in blood mononuclear cells from patients with coronary artery disease: Its association with inflammatory status and glucocorticoid sensitivity. PLoS ONE. 2017;12:e0174177 pubmed publisher
    ..Blood was collected from 57 patients with stable CAD (SCAD) and 41 healthy controls. We also included a minor group (n = 10) with acute coronary syndrome (ACS)...
  43. Sinning C, Zengin E, Waldeyer C, Seiffert M, Schnabel R, Lubos E, et al. SYNTAX score-0 patients: risk stratification in nonobstructive coronary artery disease. Clin Res Cardiol. 2016;105:901-911 pubmed
    ..2 % with acute cardiovascular syndrome (ACS) and 1500/62.8 % with stable CAD (SCAD)]...
  44. Alghamry A, Hanna J, Pelecanos A, Kyranis S, Khelgi V, O Rourke P, et al. Predictors of significant coronary artery disease in atrial fibrillation: Are cardiac troponins a useful measure. Int J Cardiol. 2016;223:744-749 pubmed publisher
    ..the value of cTnI elevation in this setting and whether it is predictive for significant coronary artery disease (sCAD)...
  45. Campo G, Vieceli Dalla Sega F, Pavasini R, Aquila G, Gallo F, Fortini F, et al. Biological effects of ticagrelor over clopidogrel in patients with stable coronary artery disease and chronic obstructive pulmonary disease. Thromb Haemost. 2017;117:1208-1216 pubmed publisher
    Patients with SCAD and concomitant COPD are at high risk of cardiovascular adverse events, due to chronic inflammation, responsible of endothelial dysfunction, oxidative stress and heightened platelet reactivity (PR)...
  46. Keir M, Dehghani P. Corticosteroids and Spontaneous Coronary Artery Dissection: A New Predisposing Factor?. Can J Cardiol. 2016;32:395.e7-8 pubmed publisher
    We describe the case of a 39-year-old woman with spontaneous coronary artery dissection (SCAD) of the left circumflex artery. We postulate that her SCAD was precipitated by high-dose corticosteroid use for the treatment of optic neuritis...
  47. Moravec F, Ali A, Abed J, Shaker S. New records of philometrids (Nematoda: Philometridae) from marine fishes off Iraq, with the erection of two new species and the first description of the male of Philometroides eleutheronemae Moravec & Manoharan, 2013. Syst Parasitol. 2016;93:129-44 pubmed publisher
    ..megalaspidis n. sp. (females) from the ovary of the torpedo scad Megalaspis cordyla (Linnaeus) (Perciformes: Carangidae), Philometra sp...
  48. Nakashima T, Noguchi T, Haruta S, Yamamoto Y, Oshima S, Nakao K, et al. Prognostic impact of spontaneous coronary artery dissection in young female patients with acute myocardial infarction: A report from the Angina Pectoris-Myocardial Infarction Multicenter Investigators in Japan. Int J Cardiol. 2016;207:341-8 pubmed publisher
    We sought to compare the prognosis of patients with spontaneous coronary artery dissection (SCAD) and atherosclerosis as the cause of acute myocardial infarction (AMI), especially in young females...
  49. Vélez P, Ocaranza Sánchez R, López Otero D, Grigorian Shamagian L, Rosa I, Guitián E, et al. Alteration of platelet GPVI signaling in ST-elevation myocardial infarction patients demonstrated by a combination of proteomic, biochemical, and functional approaches. Sci Rep. 2016;6:39603 pubmed publisher
    ..platelets from ST-elevation myocardial infarction (STEMI) patients and matched stable coronary artery disease (SCAD) controls in order to provide novel clues on the degree of involvement of GPVI signaling in the acute event...
  50. Zou K, Chen Z, Zhang P, Li M. Mitochondrial genome of the Mackerel scad Decapterus macarellus (Perciformes: Carangidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:2151-2 pubmed publisher
    The complete mitochondrial genome sequence was determined for the Mackerel scad Decapterus macarellus, one species of the economically important fish in Carangidae...
  51. Sharma S, Raut N, Potdar A. Spontaneous coronary artery dissection: Case series and review of literature. Indian Heart J. 2016;68:480-5 pubmed publisher
    Spontaneous coronary artery dissection (SCAD) is a less recognized cause of ST elevation myocardial infarction (STEMI) in clinical practice...
  52. Koltowski L, Tomaniak M, Aradi D, Huczek Z, Filipiak K, Kochman J, et al. Optimal aNtiplatelet pharmacotherapy guided by bedSIDE genetic or functional TESTing in elective PCI patients: A pilot study: ONSIDE TEST pilot. Cardiol J. 2017;24:284-292 pubmed publisher
    ..DAPT) is recommended after elective percutaneous coronary intervention (PCI) in stable coronary artery disease (SCAD) patients; however, still one-third of patients do not obtain adequate platelet inhibition that may result in ..
  53. Behnes M, Fastner C, Ansari U, Akin I. New Oral Anticoagulants in Coronary Artery Disease. Cardiovasc Hematol Disord Drug Targets. 2015;15:101-5 pubmed
    ..guideline-based recommendations about the use of new oral anticoagulants (NOACs) in patients with stable CAD (SCAD), acute coronary syndromes (ACS), percutaneous coronary interventions (PCI) and in patients with concomitant atrial ..
  54. Cerrato E, Tomassini F, Rolfo C, Gagnor A, Varbella F. Spontaneous coronary artery dissection treated with biovascular scaffolds guided by intravascular ultrasounds imaging. Cardiovasc Interv Ther. 2017;32:186-189 pubmed publisher
    ..and active 48 years' old woman presented with acute coronary syndrome due to a spontaneous coronary dissection (SCAD) treated with bioresorbable scaffolds (BVS) implantation guided by intravascular ultrasounds (IVUS) with immediate ..
  55. Chowdhury N, Klomann K, Seubert A, Buckel W. Reduction of Flavodoxin by Electron Bifurcation and Sodium Ion-dependent Reoxidation by NAD+ Catalyzed by Ferredoxin-NAD+ Reductase (Rnf). J Biol Chem. 2016;291:11993-2002 pubmed publisher
    ..With free riboflavin, the opposite is the case. Based on this behavior, we refine our previous mechanism of electron bifurcation. ..
  56. Shahraki H, Pourahmad S, Paydar S, Azad M. Improving the Accuracy of Early Diagnosis of Thyroid Nodule Type Based on the SCAD Method. Asian Pac J Cancer Prev. 2016;17:1861-4 pubmed
    ..We utilized smoothly clipped absolute deviation (SCAD) logistic regression to achieve the sparse optimal combination of factors...
  57. Neves D, Bento Ã, Fernandes R, Patrício L, Aguiar J. Spontaneous coronary artery dissection: Still a lot to learn. Rev Port Cardiol. 2017;36:59.e1-59.e5 pubmed publisher
    Non-atherosclerotic spontaneous coronary artery dissection (SCAD) is an uncommon but probably underdetected pathological substrate for acute coronary syndrome...
  58. Bu X, Niu D, Wu J, Yuan Y, Song J, Wang J. Elevated levels of pre?1-high-density lipoprotein are associated with cholesterol ester transfer protein, the presence and severity of coronary artery disease. Lipids Health Dis. 2017;16:4 pubmed publisher
    ..immunosorbent assay (ELISAs) in 88 acute coronary syndromes (ACS), 79 stable coronary artery disease (SCAD) patients and 85 control subjects...
  59. Nishiguchi T, Tanaka A, Taruya A, Ozaki Y, Nakai M, Teraguchi I, et al. Prognosis of spontaneous coronary artery dissection treated by percutaneous coronary intervention with optical coherence tomography. J Cardiol. 2017;70:524-529 pubmed publisher
    Although about half of patients with spontaneous coronary artery dissection (SCAD) face ongoing necrosis, conservative therapy is recommended due to a high complication rate in angiography-guided percutaneous coronary intervention (PCI)...
  60. Yao H, Ekou A, N djessan J, Zoumenou A, Angoran I, N guetta R. [Spontaneous coronary artery dissection: An exceptional cause of acute coronary syndrome]. J Med Vasc. 2018;43:52-55 pubmed publisher
    Spontaneous coronary artery dissection (SCAD) is an uncommon cause of acute coronary syndrome (ACS) or sudden death, which typically affects young women...
  61. Edhager A, Stenbroen V, Nielsen N, Bross P, Olsen R, Gregersen N, et al. Proteomic investigation of cultivated fibroblasts from patients with mitochondrial short-chain acyl-CoA dehydrogenase deficiency. Mol Genet Metab. 2014;111:360-368 pubmed publisher, the mitochondrial proteome of five symptomatic patients homozygous for missense variations in the SCAD gene ACADS was investigated in an extensive large-scale proteomic study to map protein perturbations linked to the disease...
  62. Ryckman K, Smith C, Jelliffe Pawlowski L, Momany A, Berberich S, Murray J. Metabolic heritability at birth: implications for chronic disease research. Hum Genet. 2014;133:1049-57 pubmed publisher
    ..SNPs (rs2066938, rs3916, rs3794215, rs555404, rs558314, rs1799958) in the short-chain acyl-CoA dehydrogenase gene (ACADS) were associated with neonatal C4 levels...
  63. Stodółkiewicz E, Rewerska B, Rzeszutko M, Tomala M, Chrustowicz A, Zmudka K, et al. Leukotrienes biosynthesis in coronary artery disease - results of Leukotrienes and Thromboxane In Myocardial Infarction (LTIMI) study. Pol Arch Intern Med. 2017;: pubmed publisher
    ..OBJECTIVES    1) to compare the baseline production of LTs in stable coronary artery disease (sCAD) and myocardial infarction (MI), and 2) assess whether increased production of LTs is associated with major adverse ..
  64. Koda S, Onda Y, Matsui H, Takahagi K, Yamaguchi Uehara Y, Shimizu M, et al. Diurnal Transcriptome and Gene Network Represented through Sparse Modeling in Brachypodium distachyon. Front Plant Sci. 2017;8:2055 pubmed publisher
    ..analysis and an Auto-Regressive eXogenous (ARX) model with a group smoothly clipped absolute deviation (SCAD) method using a time-series transcriptome dataset in a model grass, Brachypodium distachyon...
  65. Giusti L, Mantua V, Da Valle Y, Ciregia F, Ventroni T, Orsolini G, et al. Search for peripheral biomarkers in patients affected by acutely psychotic bipolar disorder: a proteomic approach. Mol Biosyst. 2014;10:1246-54 pubmed publisher
  66. Nagelkerken I, Pitt K, Rutte M, Geertsma R. Ocean acidification alters fish-jellyfish symbiosis. Proc Biol Sci. 2016;283: pubmed publisher
    ..The total time that fish (yellowtail scad) spent close to their jellyfish host in a choice arena where they could see and smell their host was approximately ..
  67. Zellweger M, Haaf P, Maraun M, Osterhues H, Keller U, Müller Brand J, et al. Predictors and prognostic impact of silent coronary artery disease in asymptomatic high-risk patients with diabetes mellitus. Int J Cardiol. 2017;244:37-42 pubmed publisher
    Evaluation of predictors of silent coronary artery disease (SCAD) in high-risk asymptomatic diabetic patients and to evaluate their two-year outcome...
  68. Du Y, Han K, Bai L, Liu P. [A rare case of spontaneous coronary artery dissection after emotional stress in a postmenopausal woman]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:1010-1013 pubmed
    Spontaneous coronary artery dissection (SCAD) is a rare cause of acute myocardial infarction. While its etiology and pathogenesis remain not fully understood, SCAD occurs most frequently in patients at a young age and of a female gender...
  69. Ahmed M, Hamra M, Ali M, Abdullah A, Arnous S, Kiernan T. Spontaneous coronary artery dissection, challenges of diagnosis and management. Future Cardiol. 2017;13:539-549 pubmed publisher
    Spontaneous coronary artery dissection (SCAD) is an increasingly recognized cause of acute coronary syndrome in young patients. No clear factors exist to predict the natural history of the disease and the prognosis of the condition...
  70. Corydon M, Vockley J, Rinaldo P, Rhead W, Kjeldsen M, Winter V, et al. Role of common gene variations in the molecular pathogenesis of short-chain acyl-CoA dehydrogenase deficiency. Pediatr Res. 2001;49:18-23 pubmed
    ABSTRACT Short-chain acyl-CoA dehydrogenase (SCAD) deficiency is considered a rare inherited mitochondrial fatty acid oxidation disorder...
  71. Battisti C, Forte F, Molinelli M, Funghini S, Pasquini E, Tassini M, et al. A new case of short-chain acyl-CoA dehydrogenase deficiency: clinical, biochemical, genetic and (1)H-NMR spectroscopic studies. Neurol Sci. 2007;28:328-30 pubmed publisher
    Short-chain-acyl-CoA-dehydrogenase (SCAD) deficiency is an inborn error of mitochondrial fatty acid metabolism caused by rare mutations as well as common susceptibility variations in the SCAD gene...
  72. Vengalil S, Preethish Kumar V, Polavarapu K, Christopher R, Gayathri N, Natarajan A, et al. Fatty acid oxidation defects presenting as primary myopathy and prominent dropped head syndrome. Neuromuscul Disord. 2017;27:986-996 pubmed publisher
    ..CoA dehydrogenase deficiency (VLCAD)?=?7; MADD?=?6; carnitine uptake defect and short chain acyl CoA dehydrogenase (SCAD) deficiency?=?1 each. The age at onset for MCAD, VLCAD and MADD ranged from 11...
  73. Al Fakih A, Algamal Z, Lee M, Aziz M. A sparse QSRR model for predicting retention indices of essential oils based on robust screening approach. SAR QSAR Environ Res. 2017;28:691-703 pubmed publisher
    ..Second, prediction of RIs was made using the proposed robust sparse QSRR with smoothly clipped absolute deviation (SCAD) penalty (RSQSRR)...
  74. Demmer J, Pal Chowdhury N, Selmer T, Ermler U, Buckel W. The semiquinone swing in the bifurcating electron transferring flavoprotein/butyryl-CoA dehydrogenase complex from Clostridium difficile. Nat Commun. 2017;8:1577 pubmed publisher
    ..One electron goes to ferredoxin and one to ?-FAD, which swings over to reduce ?-FAD to the semiquinone. Repetition affords a second reduced ferredoxin and ?-FADH-, which reduces crotonyl-CoA. ..
  75. Mahmoud A, Taduru S, Mentias A, Mahtta D, Barakat A, Saad M, et al. Trends of Incidence, Clinical Presentation, and In-Hospital Mortality Among Women With Acute Myocardial Infarction With or Without Spontaneous Coronary Artery Dissection: A Population-Based Analysis. JACC Cardiovasc Interv. 2018;11:80-90 pubmed publisher
    ..survival of women presenting with acute myocardial infarction (AMI) and spontaneous coronary artery dissection (SCAD). The clinical presentation and in-hospital survival of women with AMI and SCAD remains unclear...
  76. Naito E, Indo Y, Tanaka K. Identification of two variant short chain acyl-coenzyme A dehydrogenase alleles, each containing a different point mutation in a patient with short chain acyl-coenzyme A dehydrogenase deficiency. J Clin Invest. 1990;85:1575-82 pubmed
    Two distinct mutant alleles of the precursor (p) short chain acyl-CoA dehydrogenase (SCAD) gene were identified in a SCAD-deficient patient (YH2065) using the polymerase chain reaction to amplify cDNA synthesized from total RNA from her ..
  77. Gregersen N, Winter V, Corydon M, Corydon T, Rinaldo P, Ribes A, et al. Identification of four new mutations in the short-chain acyl-CoA dehydrogenase (SCAD) gene in two patients: one of the variant alleles, 511C-->T, is present at an unexpectedly high frequency in the general population, as was the case for 625G-->. Hum Mol Genet. 1998;7:619-27 pubmed
    We have shown previously that a variant allele of the short-chain acyl-CoA dehydrogenase ( SCAD ) gene, 625G-->A, is present in homozygous form in 7% of control individuals and in 60% of 135 patients with elevated urinary excretion of ..
  78. Hornbak M, Banasik K, Justesen J, Krarup N, Sandholt C, Andersson A, et al. The minor C-allele of rs2014355 in ACADS is associated with reduced insulin release following an oral glucose load. BMC Med Genet. 2011;12:4 pubmed publisher
    ..activity, suggested that two variants: rs2014355 in the gene encoding short-chain acyl-coenzyme A dehydrogenase (ACADS) and rs11161510 in the gene encoding medium-chain acyl-coenzyme A dehydrogenase (ACADM) impair fatty acid ?-..
  79. Zanchin T, Räber L, Koskinas K, Piccolo R, Juni P, Pilgrim T, et al. Preprocedural High-Sensitivity Cardiac Troponin T and Clinical Outcomes in Patients With Stable Coronary Artery Disease Undergoing Elective Percutaneous Coronary Intervention. Circ Cardiovasc Interv. 2016;9: pubmed publisher
    ..highly sensitive assays predicts clinical outcomes among patients with stable coronary artery disease (SCAD) treated medically...
  80. Mishra S, Ray S, Dalal J, Sawhney J, Ramakrishnan S, Nair T, et al. Management standards for stable coronary artery disease in India. Indian Heart J. 2016;68 Suppl 3:S31-S49 pubmed publisher
    ..Stable coronary artery disease (SCAD) is characterised by episodes of transient central chest pain (angina pectoris), often triggered by exercise, ..
  81. Osadnik T, Lekston A, Bujak K, Strzelczyk J, Poloński L, Gąsior M. The Relationship between VEGFA and TGFB1 Polymorphisms and Target Lesion Revascularization after Elective Percutaneous Coronary Intervention. Dis Markers. 2017;2017:8165219 pubmed publisher
    ..A total of 676 patients (805 lesions) with stable coronary artery disease (SCAD) who received elective percutaneous coronary intervention (PCI) with at least one bare-metal stent implantation ..
  82. Munguti C, Ndunda P, Muutu T. Sudden Death from Spontaneous Coronary Artery Dissection due to Polyarteritis Nodosa. Cureus. 2017;9:e1737 pubmed publisher
    Spontaneous coronary artery dissection (SCAD) is an emerging and rare cause of acute coronary syndrome and sudden cardiac death...
  83. Nagan N, Kruckeberg K, Tauscher A, Bailey K, Rinaldo P, Matern D. The frequency of short-chain acyl-CoA dehydrogenase gene variants in the US population and correlation with the C(4)-acylcarnitine concentration in newborn blood spots. Mol Genet Metab. 2003;78:239-46 pubmed
    Short-chain acyl-CoA dehydrogenase (SCAD) deficiency is a clinically heterogeneous disorder. The clinical phenotype varies from fatal metabolic decompensation in early life to subtle adult onset, some patients remain asymptomatic...
  84. Tein I, Elpeleg O, Ben Zeev B, Korman S, Lossos A, Lev D, et al. Short-chain acyl-CoA dehydrogenase gene mutation (c.319C>T) presents with clinical heterogeneity and is candidate founder mutation in individuals of Ashkenazi Jewish origin. Mol Genet Metab. 2008;93:179-89 pubmed
    ..625G>A variant on the other in the short-chain acyl-CoA dehydrogenase (SCAD) gene (ACADS). All were of Ashkenazi Jewish origin in which group we found a c...
  85. Sjöholm L, Kovanen L, Saarikoski S, Schalling M, Lavebratt C, Partonen T. CLOCK is suggested to associate with comorbid alcohol use and depressive disorders. J Circadian Rhythms. 2010;8:1 pubmed publisher
    ..Together with previous reports it indicates that the CLOCK variations we found here may be a vulnerability factor to depression given the exposure to alcohol in individuals having AUD. ..
  86. Kim Y, Cheon C, Park K, Park S, Kim G, Yoo H, et al. Novel and Recurrent ACADS Mutations and Clinical Manifestations Observed in Korean Patients with Short-chain Acyl-coenzyme a Dehydrogenase Deficiency. Ann Clin Lab Sci. 2016;46:360-6 pubmed
    ..the first step in mitochondrial short-chain ?-oxidation, and its deficiency is caused by mutations in the ACADS We sought to investigate the spectrum ACADS mutations and associated clinical manifestations in Korean patients ..
  87. Roule V, Blanchart K, Lemaitre A, Bignon M, Sabatier R, Beygui F. Recurrent unexpected myocardial infarction in a young woman: Insights on spontaneous coronary artery dissection and multimodality imaging. Cardiovasc Revasc Med. 2018;19:123-125 pubmed publisher
    ..An optical coherence tomography (OCT) revealed a spontaneous coronary artery dissection (SCAD) with an extensive compressive mural hematoma without any intimal tear. Conservative treatment was continued...
  88. Finocchiaro G, Ito M, Tanaka K. Purification and properties of short chain acyl-CoA, medium chain acyl-CoA, and isovaleryl-CoA dehydrogenases from human liver. J Biol Chem. 1987;262:7982-9 pubmed
    ..The pattern of substrate specificity for these enzymes determined using ETF as electron acceptor significantly differed from that determined using PMS. All of them were severely inhibited by (methylenecyclopropyl)acetyl-CoA. ..
  89. Kelly C, Hinsdale M, Wood P. Cloning and characterization of the mouse short-chain acyl-CoA dehydrogenase cDNA. Genomics. 1993;18:137-40 pubmed
    Short-chain acyl-CoA dehydrogenase (SCAD) is one of five homologous dehydrogenases that catalyze the first reaction in the beta-oxidation of fatty acids. As the name implies, the substrate for this enzyme is short-chain acyl-CoA (C4-C6)...
  90. Yang Z, Lantz P, Ibdah J. Post-mortem analysis for two prevalent beta-oxidation mutations in sudden infant death. Pediatr Int. 2007;49:883-7 pubmed
    ..The present data support post-mortem molecular analysis for the MCAD A985G and MTP G1528C prevalent mutations in cases of sudden and unexplained infant death associated with hepatic steatosis. ..
  91. Kovanen L, Saarikoski S, Haukka J, Pirkola S, Aromaa A, Lonnqvist J, et al. Circadian clock gene polymorphisms in alcohol use disorders and alcohol consumption. Alcohol Alcohol. 2010;45:303-11 pubmed publisher
    ..04) and NPY Pro7 decreased (P = 0.01) the risk of alcohol dependence. ARNTL, ARNTL2, VIP and ADCYAP1 were indicated as having influence on alcohol use or abuse. The role of DRD2 and NPY on alcohol dependence was also supported. ..