ACACA

Summary

Gene Symbol: ACACA
Description: acetyl-CoA carboxylase alpha
Alias: ACAC, ACACAD, ACC, ACC1, ACCA, acetyl-CoA carboxylase 1, ACC-alpha, acetyl-Coenzyme A carboxylase alpha
Species: human
Products:     ACACA

Top Publications

  1. Ha J, Daniel S, Broyles S, Kim K. Critical phosphorylation sites for acetyl-CoA carboxylase activity. J Biol Chem. 1994;269:22162-8 pubmed
    Acetyl-CoA carboxylase (ACC) is rapidly regulated by reversible phosphorylation; phosphorylation inactivates ACC, whereas dephosphorylation activates the enzyme...
  2. Conde E, Suarez Gauthier A, Garcia Garcia E, Lopez Rios F, Lopez Encuentra A, Garcia Lujan R, et al. Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas. Hum Pathol. 2007;38:1351-60 pubmed
    ..used immunohistochemistry to evaluate the levels of LKB1 and the phosphorylated form of the acetyl-CoA carboxylase (ACC) protein in a variety of human adult normal tissues and in 159 lung carcinomas...
  3. Munday M, Campbell D, Carling D, Hardie D. Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase. Eur J Biochem. 1988;175:331-8 pubmed
    ..They also open the way to experiments which could establish the physiological roles of these protein kinases in the control of fatty acid synthesis. ..
  4. Dong L, Han X, Tao X, Xu L, Xu Y, Fang L, et al. Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling. Foods. 2018;7: pubmed publisher
    ..the TFs obviously reduced the expression levels of SREBP-1c (sterol regulatory element-binding proteins-1c), ACC1 (acetyl-CoA carboxylase-1), FASN (fatty acid synthase), and SCD1 (stearoyl-coenzyme A desaturase 1), and improved ..
  5. Lim E, Lim J, Kim E, Kim Y, Shin J, Seok P, et al. Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice. Nutrients. 2016;8: pubmed
    ..protein-1C (SREBP-1C), sterol regulatory element-binding protein-2 (SREBP-2), acetyl-CoA carboxylase (ACC), HMG-CoA reductase (HMGCR), ATP-binding cassette transporter G5/G8 (ABCG5/8), cholesterol 7 alpha-hydroxylase (..
  6. Park S, Sung Y, Jang S, Nho K, Choi G, Kim H. The Korean herbal medicine, Do In Seung Gi-Tang, attenuates atherosclerosis via AMPK in high-fat diet-induced ApoE(-/-) mice. BMC Complement Altern Med. 2016;16:352 pubmed publisher
    ..fatty acid synthase (FAS), adenosine monophosphate-activated protein kinase (AMPK), and acetyl-coA carboxylase (ACC) in the aorta or liver tissues was measured by western blot analysis...
  7. Veeramani C, Alsaif M, Al Numair K. Lavatera critica, a green leafy vegetable, controls high fat diet induced hepatic lipid accumulation and oxidative stress through the regulation of lipogenesis and lipolysis genes. Biomed Pharmacother. 2017;96:1349-1357 pubmed publisher
    ..as fatty acid synthase (FAS), sterol-regulatory-element-binding protein-1c (SREBP-1c), and acetyl-CoA carboxylase (ACC)...
  8. Pan Y, Luo Z, Zhuo M, Wei C, Chen G, Song Y. Oxidative stress and mitochondrial dysfunction mediated Cd-induced hepatic lipid accumulation in zebrafish Danio rerio. Aquat Toxicol. 2018;199:12-20 pubmed publisher
    ..G6PD) and malic enzyme (ME), and the mRNA level of fatty acid synthase (fas), acetyl-CoA carboxylase alpha (acaca), glucose 6-phosphate dehydrogenase (g6pd) and malic enzyme (me), but reduced the mRNA level of carnitine ..
  9. Sun J, Liu X, Cong L, Li H, Zhang C, Chen J, et al. Metabolomics study of the therapeutic mechanism of Schisandra Chinensis lignans in diet-induced hyperlipidemia mice. Lipids Health Dis. 2017;16:145 pubmed publisher
    ..level of hepatic lipogenesis genes such as SREBP-1c, fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), and decreased the mRNA expression of liver X receptor α (LXRα)...

More Information

Publications148 found, 100 shown here

  1. Nguyen P, GREENE E, Ishola P, Huff G, Donoghue A, Bottje W, et al. Chronic Mild Cold Conditioning Modulates the Expression of Hypothalamic Neuropeptide and Intermediary Metabolic-Related Genes and Improves Growth Performances in Young Chicks. PLoS ONE. 2015;10:e0142319 pubmed publisher
    ..CMCC significantly down regulated the expression of lipogenic genes namely FAS, acetyl-CoA carboxylase alpha (ACCα) and malic enzyme (ME) and their related transcription factors sterol regulatory element binding protein 1/2 (..
  2. Hwang K, Hwang Y, Kim G, Choe J. Extracts from Aralia elata (Miq) Seem alleviate hepatosteatosis via improving hepatic insulin sensitivity. BMC Complement Altern Med. 2015;15:347 pubmed publisher
    ..of sterol regulatory element-binding protein 1(SREBP-1), Fatty acid synthase (FAS), Acetyl-CoA carboxylase (ACC) 1 and 2, Peroxisome proliferator activated receptor-α (PPARα), and carnitine palmitoyl transferase 1(CPT-1) ..
  3. Hsu J, Lin H, Hsu C, Chen B, Chen J. Aqueous Extract of Pepino (Solanum muriactum Ait) Leaves Ameliorate Lipid Accumulation and Oxidative Stress in Alcoholic Fatty Liver Disease. Nutrients. 2018;10: pubmed publisher
    ..hepatic lipogenic enzymes, including sterol regulatory element-binding protein (SREBP)-1c, acetyl-CoA carboxylase (ACC), and fatty acid synthase (FAS) (all p < 0.05)...
  4. Kim J, Kang E, Park M, Kim J, Kim S, Jeung E, et al. The adverse effect of 4-tert-octylphenol on fat metabolism in pregnant rats via regulation of lipogenic proteins. Environ Toxicol Pharmacol. 2015;40:284-91 pubmed publisher
    ..OP and EE negatively regulated the expression of lipogenic enzymes, including FAS (fatty acid synthase), ACC-1 (acetyl-CoA carboxylase-1), and SCD-1 (stearoyl-CoA desaturase-1)...
  5. Shi Q, Sun N, Kou H, Wang H, Zhao H. Chronic effects of mercury on Bufo gargarizans larvae: Thyroid disruption, liver damage, oxidative stress and lipid metabolism disorder. Ecotoxicol Environ Saf. 2018;164:500-509 pubmed publisher
    ..up regulated mRNA expression of fatty acid elongase (FAE), fatty acid synthetase (FAS) and Acetyl CoA Carboxylase (ACC)...
  6. Naowaboot J, Wannasiri S, Pannangpetch P. Morin attenuates hepatic insulin resistance in high-fat-diet-induced obese mice. J Physiol Biochem. 2016;72:269-80 pubmed publisher
    ..sterol regulatory element binding protein 1c (SREBP1c), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC) and up-regulated hepatic carnitine palmitoyltransferase 1a (CPT1a) expression...
  7. Choi S, Lim J, Kim M, Kim E, Kim Y, Choi B, et al. Adiponectin receptor agonist AdipoRon decreased ceramide, and lipotoxicity, and ameliorated diabetic nephropathy. Metabolism. 2018;85:348-360 pubmed publisher
    ..receptor ? (PPAR?), phospho-Thr473 Akt, phospho-Ser79Acetyl-CoA carboxylase (ACC), and phospho-Ser1177 endothelial NO synthase (eNOS), and down-regulation of protein phosphatase 2A (..
  8. Du X, Shen T, Wang H, Qin X, Xing D, Ye Q, et al. Adaptations of hepatic lipid metabolism and mitochondria in dairy cows with mild fatty liver. J Dairy Sci. 2018;101:9544-9558 pubmed publisher
    ..protein 1c (SREBP-1c) and peroxisome proliferator-activated receptor-? (PPAR?) and mRNA levels of acetyl CoA carboxylase 1 (ACC1), fatty acid synthase (FAS), acyl-CoA oxidase (ACO), and carnitine palmitoyltransferase 1A (CPT1A) ..
  9. Chen H, Tsai T, Tsai Y, Liao J, Yen C, Chen C. Kefir peptides prevent high-fructose corn syrup-induced non-alcoholic fatty liver disease in a murine model by modulation of inflammation and the JAK2 signaling pathway. Nutr Diabetes. 2016;6:e237 pubmed publisher
    ..In addition, kefir peptides markedly increased phosphorylation of AMPK to downregulate its targeted enzymes, ACC (acetyl-CoA carboxylase) and SREBP-1c (sterol regulatory element-binding protein 1), and inhibited de novo ..
  10. Woo M, Song Y, Kang K, Noh J. Anti-Obesity Effects of Collagen Peptide Derived from Skate (Raja kenojei) Skin Through Regulation of Lipid Metabolism. Mar Drugs. 2018;16: pubmed publisher
    ..sterol regulatory element binding protein-1 (SREBP-1), fatty acid synthase (FAS), and acetyl-CoA carboxylase (ACC)) and cholesterol synthesis (SREBP-2 and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR)) and upregulating those ..
  11. Cuthbert C, Foster J, Ramdath D. A maternal high-fat, high-sucrose diet alters insulin sensitivity and expression of insulin signalling and lipid metabolism genes and proteins in male rat offspring: effect of folic acid supplementation. Br J Nutr. 2017;118:580-588 pubmed publisher
    ..v-Raf-1 murine leukaemia viral oncogene homolog 1 (Raf1) in offspring skeletal muscle and acetyl-CoA carboxylase (Acaca), fatty acid synthase and phosphatidylinositol-4,5-biphosphate 3-kinase, catalytic subunit ? in offspring liver...
  12. Shinohara S, Gu Y, Yang Y, Furuta Y, Tanaka M, Yue X, et al. Ethanol extracts of chickpeas alter the total lipid content and expression levels of genes related to fatty acid metabolism in mouse 3T3-L1 adipocytes. Int J Mol Med. 2016;38:574-84 pubmed publisher
    ..e., liver kinase B1 (LKB1), acetyl-CoA carboxylase (ACC) and AMPK, by phosphorylation, which may lead to the suppression of reactions from acetyl-CoA to SFA via malonyl-..
  13. Lavandera J, Gerstner C, Saín J, Fariña A, Gonzalez M, Bernal C. Maternal conjugated linoleic acid modulates TAG metabolism in adult rat offspring. Br J Nutr. 2017;118:906-913 pubmed publisher
    ..in the CLA/CLA group, related to a significant reduction of fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC) and glucose-6-phosphate dehydrogenase enzyme activities, as well as to the mRNA levels of FAS, ACC, stearoyl-CoA ..
  14. Liu H, Zhong H, Yin Y, Jiang Z. Genistein has beneficial effects on hepatic steatosis in high fat-high sucrose diet-treated rats. Biomed Pharmacother. 2017;91:964-969 pubmed publisher
    ..levels of liver AMP-activated protein kinase (AMPK), phosphorylation of AMPK (p-AMPK), acetyl-CoA carboxylase (ACC), phosphorylation of ACC (p-ACC) and sterol regulatory element binding protein 1 (SREBP-1) were determined by ..
  15. Xing X, Li D, Chen D, Zhou L, Chonan R, Yamahara J, et al. Mangiferin treatment inhibits hepatic expression of acyl-coenzyme A:diacylglycerol acyltransferase-2 in fructose-fed spontaneously hypertensive rats: a link to amelioration of fatty liver. Toxicol Appl Pharmacol. 2014;280:207-15 pubmed publisher
    ..The anti-steatotic effect of mangiferin may occur independently of the hepatic signals associated with de novo fatty acid synthesis and oxidation. ..
  16. Yin M, Zhang P, Yu F, Zhang Z, Cai Q, Lu W, et al. Grape seed procyanidin B2 ameliorates hepatic lipid metabolism disorders in db/db mice. Mol Med Rep. 2017;16:2844-2850 pubmed publisher
    ..The expression of hepatic AMPK, phosphorylated acetyl‑CoA carboxylase (ACC), carnitine palmitoyl transferase 1 (CPT1) and 4‑hydroxynonenal (4‑HNE) was measured by western blot ..
  17. Meng X, Li S, Qin C, Zhu Z, Hu W, Yang L, et al. Intestinal microbiota and lipid metabolism responses in the common carp (Cyprinus carpio L.) following copper exposure. Ecotoxicol Environ Saf. 2018;160:257-264 pubmed publisher
    ..The mRNA levels of lipogenic enzymes (acetyl-CoA carboxylase 1 (ACC-1) and fatty acid synthase (FAS)) and sterol-regulator element-binding protein-1 (SREBP-1) in liver tissue and ..
  18. Ma J, Kang S, Meng X, Kang A, Park J, Park Y, et al. Effects of Rhizome Extract of Dioscorea batatas and Its Active Compound, Allantoin, on the Regulation of Myoblast Differentiation and Mitochondrial Biogenesis in C2C12 Myotubes. Molecules. 2018;23: pubmed publisher
    ..A, mitochondrial (TFAM), and the phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) were determined in C2C12 myotubes by reverse transcriptase (RT)-polymerase chain reaction (RT-PCR) or western blot...
  19. Oliveira D, Chalfun Junior A, Chizzotti M, Barreto H, Coelho T, Paiva L, et al. Expression of genes involved in lipid metabolism in the muscle of beef cattle fed soybean or rumen-protected fat, with or without monensin supplementation. J Anim Sci. 2014;92:5426-36 pubmed publisher
    ..001). Lipid sources and monensin interact and alter the expression of PPAR-α, SCD, acetyl CoA carboxylase α (ACACA), LPL, FABP4, and GPX1...
  20. Yang Y, Lin Y, Duan X, Lv H, Xing W, Li Q, et al. The effects of cell death-inducing DNA fragmentation factor-?-like effector C (CIDEC) on milk lipid synthesis in mammary glands of dairy cows. J Dairy Sci. 2017;100:4014-4024 pubmed publisher
    ..These genes included those for acetyl-CoA carboxylase (ACC, -60%), fatty acid synthase (FASN, -65%), acyl-CoA synthetase short-chain family member 2 (ACSS2, -50%), acyl-CoA ..
  21. Wang C, Yuan R, Zhuang W, Sun J, Wu J, Li H, et al. Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice. Lipids Health Dis. 2016;15:195 pubmed
    ..These findings demonstrate the hepatoprotective effects of SCP in a mouse model of NAFLD; the effects may be mediated via downregulation of LXR?/SREBP-1c/FAS/ACC and SREBP-2/HMGCR signaling pathways in the liver.
  22. Zhao Z, Barcus M, Kim J, Lum K, Mills C, Lei X. High Dietary Selenium Intake Alters Lipid Metabolism and Protein Synthesis in Liver and Muscle of Pigs. J Nutr. 2016;146:1625-33 pubmed publisher
    ..S (SELS); deiodinases, iodothyronine, type I (DIO1); and thioredoxin reductase 1 (TXNRD1; 50%; selenoproteins); and ACC1 and FASN (35-51%; lipogenesis)...
  23. Panneerselvam L, Raghunath A, Perumal E. Acute fluoride poisoning alters myocardial cytoskeletal and AMPK signaling proteins in rats. Int J Cardiol. 2017;229:96-101 pubmed publisher
    ..A significant increase in phosphorylation of AMPK? (Thr172), AMPKß1 (Ser108) and Acetyl-coA carboxylase (ACC) (Ser79) in the myocardium and associated ATP deprivation were found in acute F- intoxicated rats...
  24. Gou S, Huang H, Chen X, Liu J, He M, Ma Y, et al. Lipid-lowering, hepatoprotective, and atheroprotective effects of the mixture Hong-Qu and gypenosides in hyperlipidemia with NAFLD rats. J Chin Med Assoc. 2016;79:111-21 pubmed publisher
    ..sterol response element-binding protein-1c (SREBP-1c), fatty acid synthase (FAS), acetyl-CoA carboxylase-1 (ACC-1) and carnitine palmitoyl transferase-1(CPT-1) in hepatic tissue were also altered by a high-fat diet fed to ..
  25. Wang Y, Li J, Han M, Wang W, Li Y. Prevention and treatment effect of total flavonoids in Stellera chamaejasme L. on nonalcoholic fatty liver in rats. Lipids Health Dis. 2015;14:85 pubmed publisher
    ..The mRNA expression of hepatic acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), Leptin (LEP) and sterol regulatory element binding protein (SREBP)-1c as well as ..
  26. Weston Green K, Babic I, De Santis M, Pan B, Montgomery M, Mitchell T, et al. Disrupted sphingolipid metabolism following acute clozapine and olanzapine administration. J Biomed Sci. 2018;25:40 pubmed publisher
    ..synthase 2 (CerS2), elongation of very long-chain fatty acid 1 (ELOVL1), fatty acid synthase (FAS) and acetyl CoA carboxylase 1 (ACC1)), ER stress markers (inositol-requiring enzyme 1 (IRE1) and eukaryotic initiation factor (eIF2?) ..
  27. E Rogvi R, Sommerlund M, Vestergaard E. [Aplasia cutis congenita is a rare and possibly overlooked congenital anomaly]. Ugeskr Laeger. 2014;176: pubmed
    Aplasia cutis congenita (ACC) is a rare congenital defect of the skin. In this study we present the diagnosis and management of the condition...
  28. Tong X, Christian P, Zhao M, Wang H, Moreau R, Su Q. Activation of hepatic CREBH and Insig signaling in the anti-hypertriglyceridemic mechanism of R-α-lipoic acid. J Nutr Biochem. 2015;26:921-8 pubmed publisher
    ..SREBP-1c, which subsequently inhibited expression of genes involved in fatty acid synthesis, including FASN, ACC and SCD-1, and reduced triglyceride (TG) contents in both glucose-treated cells and ZDF rat livers...
  29. Eo H, Park J, Jeon Y, Lim Y. Ameliorative Effect of Ecklonia cava Polyphenol Extract on Renal Inflammation Associated with Aberrant Energy Metabolism and Oxidative Stress in High Fat Diet-Induced Obese Mice. J Agric Food Chem. 2017;65:3811-3818 pubmed publisher
    ..ECPE treatment lowered the protein levels related to lipid accumulation (SREBP1c, ACC & FAS), inflammation (NLRP3 inflammasome, NF?B, MCP-1, TNF-? & CRP), and oxidative stress (Nrf2, HO-1, ..
  30. Layfield C, Rose J, Alford A, Snyder S, Apple F, Chowdhury F, et al. Effectiveness of practices for improving the diagnostic accuracy of Non ST Elevation Myocardial Infarction in the Emergency Department: A Laboratory Medicine Best Practicesâ„¢ systematic review. Clin Biochem. 2015;48:204-12 pubmed publisher
    ..The current ACC/AHA guidelines recommend using cardiac troponin assays with a 99th percentile upper reference limit (URL) ..
  31. Jansen M, van Oers H, Middelweerd M, Van De Goor I, Ruwaard D. Conditions for sustainability of Academic Collaborative Centres for Public Health in the Netherlands: a mixed methods design. Health Res Policy Syst. 2015;13:36 pubmed publisher
    ..Mode-2 knowledge production, the Dutch government in 2006 initiated the so-called Academic Collaborative Centres (ACC) for Public Health...
  32. Pan Y, Yang C, Gao X, Peng T, Bi R, Xi J, et al. Spirotetramat resistance adaption analysis of Aphis gossypii Glover by transcriptomic survey. Pestic Biochem Physiol. 2015;124:73-80 pubmed publisher
    ..The acetyl-CoA carboxylase (ACC) genes in the SR and SS libraries both contain four single nucleotide polymorphisms (SNPs), with three common SNPs: ..
  33. Sakaki M, Yoo H, Nga L, Lee T, Thayer J, Mather M. Heart rate variability is associated with amygdala functional connectivity with MPFC across younger and older adults. Neuroimage. 2016;139:44-52 pubmed publisher
    ..Evidence suggests that the medial prefrontal cortex (mPFC) and adjacent anterior cingulate (ACC) modulate amygdala activity during emotion regulation...
  34. Rhodes L. New approaches to non-surgical sterilization for dogs and cats: Opportunities and challenges. Reprod Domest Anim. 2017;52 Suppl 2:327-331 pubmed publisher
    ..The Alliance for Contraception of Cats and Dogs (ACC&D) is helping to research practical methods of marking sterilized animals to avoid costly retreatment and ..
  35. Galle M, Kladniew B, Castro M, Villegas S, Lacunza E, Polo M, et al. Modulation by geraniol of gene expression involved in lipid metabolism leading to a reduction of serum-cholesterol and triglyceride levels. Phytomedicine. 2015;22:696-704 pubmed publisher
    ..transcription factor (SREBF2), the very-low-density-lipoprotein receptor (VLDLR), and the acetyl-CoA carboxylase (ACACA) were determined by real-time RT-PCR...
  36. Zhang Z, Chen X, Yu P, Zhang Q, Sun X, Gu H, et al. Effect of rs1344706 in the ZNF804A gene on the connectivity between the hippocampal formation and posterior cingulate cortex. Schizophr Res. 2016;170:48-54 pubmed publisher
    ..three subconnections: from lHF to posterior cingulate cortex (PCC), from PCC to anterior cingulated cortex (ACC), and from ACC to rDLPFC...
  37. Liu Y, Li Y, Wang X, Ma Q, Zhu C, Li Z, et al. Mitochondrial tRNA mutations in Chinese hypertensive individuals. Mitochondrion. 2016;28:1-7 pubmed publisher
    ..on the AC loop, tRNA(Met) C4467T, tRNA(Trp) T5578C, tRNA(Lys) A8296G, tRNA(Arg) T10463C and tRNA(Thr) C15891T on ACC stem, and tRNA(Ser(UCN)) C7492T on D-A junction, while the other tRNA variants were polymorphisms...
  38. Virani S, Pokharel Y, Steinberg L, Chan W, Akeroyd J, Gowani S, et al. Provider understanding of the 2013 ACC/AHA cholesterol guideline. J Clin Lipidol. 2016;10:497-504.e4 pubmed publisher
    Providers' understanding of the 2013 American College of Cardiology (ACC)/American Heart Association (AHA) cholesterol guideline in clinical practice is not known...
  39. Si X, Zhou Z, Strappe P, Blanchard C. A comparison of RS4-type resistant starch to RS2-type resistant starch in suppressing oxidative stress in high-fat-diet-induced obese rats. Food Funct. 2017;8:232-240 pubmed publisher
    ..Moreover, the expression levels of the fatty acid synthesis associated genes ACC and Fads1, the triglyceride synthesis and metabolism-related gene SREBP-1, the adipocyte differentiation gene PPAR?,..
  40. Rikandi E, Mäntylä T, Lindgren M, Kieseppä T, Suvisaari J, Raij T. Connectivity of the precuneus-posterior cingulate cortex with the anterior cingulate cortex-medial prefrontal cortex differs consistently between control subjects and first-episode psychosis patients during a movie stimulus. Schizophr Res. 2018;199:235-242 pubmed publisher
    ..scanners between the midline regions of the PC-PCC and the anterior cingulate cortex-medial prefrontal cortex (ACC-mPFC). We found no group differences in any of the diffusion tensor imaging measures...
  41. Ashare R, Lerman C, Cao W, Falcone M, Bernardo L, Ruparel K, et al. Nicotine withdrawal alters neural responses to psychosocial stress. Psychopharmacology (Berl). 2016;233:2459-67 pubmed publisher
    ..for the stress induction minus control contrast: inferior frontal gyrus (IFG), anterior/para cingulate cortex (ACC), precuneus, and supramarginal gyrus (SMG)...
  42. Pornpattananangkul N, Hariri A, Harada T, Mano Y, Komeda H, Parrish T, et al. Cultural influences on neural basis of inhibitory control. Neuroimage. 2016;139:114-126 pubmed publisher
    ..in several inhibitory-control areas, such as the inferior frontal gyrus (IFG) and anterior cingulate cortex (ACC)...
  43. Bader I, Decker E, Mayr J, Lunzer V, Koch J, Boltshauser E, et al. MKS1 mutations cause Joubert syndrome with agenesis of the corpus callosum. Eur J Med Genet. 2016;59:386-91 pubmed publisher
    ..We present the phenotype and genotype of a child with severe JS and agenesis of the corpus callosum (ACC)...
  44. Zheng T, Hao X, Wang Q, Chen L, Jin S, Bian F. Entada phaseoloides extract suppresses hepatic gluconeogenesis via activation of the AMPK signaling pathway. J Ethnopharmacol. 2016;193:691-699 pubmed publisher
    ..with TSEP elevated the phosphorylation of AMPK, which in turn promoted the phosphorylation of acetyl coenzyme A (ACC) and Akt/glycogen synthase kinase 3? (GSK3?), respectively...
  45. Hermens D, Hatton S, Lee R, Naismith S, Duffy S, Paul Amminger G, et al. In vivo imaging of oxidative stress and fronto-limbic white matter integrity in young adults with mood disorders. Eur Arch Psychiatry Clin Neurosci. 2018;268:145-156 pubmed publisher
    ..GSH concentration was measured in anterior cingulate cortex (ACC) and hippocampus (HIPP)...
  46. Harigaya W, Takahashi H. Effects of glucose and ethylene on root hair initiation and elongation in lettuce (Lactuca sativa L.) seedlings. J Plant Res. 2018;131:543-554 pubmed publisher
    ..0). Adding 1-aminocyclopropane-1-carboxylic-acid (ACC) to the medium rescued the induction, while adding glucose did not...
  47. Samms R, Murphy M, Fowler M, Cooper S, Emmerson P, Coskun T, et al. Dual effects of fibroblast growth factor 21 on hepatic energy metabolism. J Endocrinol. 2015;227:37-47 pubmed publisher
    ..of PD kinase-4 (PDK4, a negative regulator of PDC), the phosphorylated (inhibited) form of acetyl-CoA carboxylase (ACC, a negative regulator of delivery of fatty acids into the mitochondria) and the transcriptional co-regulators of ..
  48. Vahmani P, Meadus W, Rolland D, Duff P, Dugan M. Trans10,cis15 18:2 Isolated from Beef Fat Does Not Have the Same Anti-Adipogenic Properties as Trans10,cis12-18:2 in 3T3-L1 Adipocytes. Lipids. 2016;51:1231-1239 pubmed
    ..Trans10,cis12 also decreased (P < 0.05) the expression of genes related to fatty acid synthesis (ACACA, FASN), delta-9 desaturation (SCD1), fatty acid elongation (ELOVL5), and fatty acid uptake (LPL) and upregulated (..
  49. Świątek Kościelna B, Kałużna E, Strauss E, Januszkiewicz Lewandowska D, Bereszyńska I, Wysocki J, et al. Interleukin 10 gene single nucleotide polymorphisms in Polish patients with chronic hepatitis C: Analysis of association with severity of disease and treatment outcome. Hum Immunol. 2017;78:192-200 pubmed publisher
    ..Moreover, it was found that the -819C allele might be associated with SVR and that the ACCA haplotype and intermediate IL-10 producer ACC haplotype are associated with SVR and non-relapse...
  50. Yao G, Zhang Y, Wang D, Yang R, Sang H, Han L, et al. GDM-Induced Macrosomia Is Reversed by Cav-1 via AMPK-Mediated Fatty Acid Transport and GLUT1-Mediated Glucose Transport in Placenta. PLoS ONE. 2017;12:e0170490 pubmed publisher
    ..related proteins, including phosphorylated-AMPK?(Thr172), AMPK?, phosphorylated-Acetyl-CoA carboxylase(Ser79) (p-ACC(Ser79)), ACC and glucose transporter 1 (GLUT1) in placenta between the three groups...
  51. Khan A, Subramaniam S, Dramane G, Khelifi D, Khan N. ERK1 and ERK2 activation modulates diet-induced obesity in mice. Biochimie. 2017;137:78-87 pubmed publisher
    ..liver ERK2 phosphorylation in Erk1-/- obese mice which also had high liver acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FAS) mRNA expression, suggesting high lipogenesis in these animals...
  52. Shen S, Neyens D. Assessing drivers' response during automated driver support system failures with non-driving tasks. J Safety Res. 2017;61:149-155 pubmed publisher
    ..with two levels of automated driving: (a) driving with no automation and (b) driving with adaptive cruise control (ACC) and lane keeping (LK) systems engaged; and also two levels of a non-driving task (a) watching a movie or (b) no ..
  53. Wang C, Xin M, Zhou X, Liu C, Li S, Liu D, et al. The novel ethylene-responsive factor CsERF025 affects the development of fruit bending in cucumber. Plant Mol Biol. 2017;95:519-531 pubmed publisher
    ..The application of exogenous 1-aminocyclopropane-l-carboxylic acid (ACC) to straight fruits from control plants promoted fruit bending...
  54. Huang C, Hang L, Chen C, Wu J, Tsai F. Polymorphisms of TAP1 transporter genes in Chinese patients with systemic lupus erythematosus in Taiwan. Rheumatol Int. 2004;24:130-2 pubmed
    ..no significant differences between the healthy individuals and SLE patients with TAP1-1 (Dpn II) and TAP1-2 (Acc I) polymorphisms ( P=0.10 and 0.36, respectively)...
  55. Grossi D, Longarzo M, Quarantelli M, Salvatore E, Cavaliere C, De Luca P, et al. Altered functional connectivity of interoception in illness anxiety disorder. Cortex. 2017;86:22-32 pubmed publisher
    ..hippocampus and nucleus accumbens bilaterally, and with higher connectivity between left anterior cingulate cortex (ACC) and left orbitofrontal cortex (OFC)...
  56. Wang G, van Eijk J, Demirakca T, Sack M, Krause Utz A, Cackowski S, et al. ACC GABA levels are associated with functional activation and connectivity in the fronto-striatal network during interference inhibition in patients with borderline personality disorder. Neuroimage. 2017;147:164-174 pubmed publisher
    ..control, a function mainly regulated by ?-Aminobutyric acid (GABA) levels in the anterior cingulate cortex (ACC) and the fronto-striatal system...
  57. Wang H, Zhou Z, Li Y, Chen Z, Lu P, Wang W, et al. Comparison of machine learning methods for classifying mediastinal lymph node metastasis of non-small cell lung cancer from 18F-FDG PET/CT images. EJNMMI Res. 2017;7:11 pubmed publisher
    ..was conducted using 10 times 10-fold cross-validation based on the criterion of sensitivity, specificity, accuracy (ACC), and area under the ROC curve (AUC)...
  58. Ruggiero C, Doghman Bouguerra M, Sbiera S, Sbiera I, Parsons M, Ragazzon B, et al. Dosage-dependent regulation of VAV2 expression by steroidogenic factor-1 drives adrenocortical carcinoma cell invasion. Sci Signal. 2017;10: pubmed publisher
    Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a dismal prognosis. Genomic studies have enabled progress in our understanding of the molecular bases of ACC, but factors that influence its prognosis are lacking...
  59. Gao M, Liu D. CRISPR/Cas9-based Pten knock-out and Sleeping Beauty Transposon-mediated Nras knock-in induces hepatocellular carcinoma and hepatic lipid accumulation in mice. Cancer Biol Ther. 2017;18:505-512 pubmed publisher
    ..by upregulated expression of genes responsible for lipogenesis and fatty acid sequestration, such as Srebpf1, Acc, Pparg and its downstream targets...
  60. Wei D, Pan K, Tong S. Surface Modification and Heat Generation of FePt Nanoparticles. Materials (Basel). 2017;10: pubmed publisher
    The chemical reduction of ferric acetylacetonate (Fe(acac)?) and platinum acetylacetonate (Pt(acac)?) using the polyol solvent of phenyl ether as an agent as well as an effective surfactant has successfully yielded monodispersive FePt ..
  61. Umezawa M, Nakamura M, El Ghoneimy A, Onoda A, Shaheen H, Hori H, et al. Impact of diesel exhaust exposure on the liver of mice fed on omega-3 polyunsaturated fatty acids-deficient diet. Food Chem Toxicol. 2018;111:284-294 pubmed publisher
    ..diet increased hepatic lipid droplets accumulation and expression of genes promoting fatty acid synthesis: Acaca, Acacb, and Scd1...
  62. Zhang W, Chen W, He L, Wang Q, Sheng X. Characterization of Mn-resistant endophytic bacteria from Mn-hyperaccumulator Phytolacca americana and their impact on Mn accumulation of hybrid penisetum. Ecotoxicol Environ Saf. 2015;120:369-76 pubmed publisher
    ..92%, and 11% of the bacteria produced indole acetic acid (IAA), siderophore, and 1-aminocyclopropane-1-carboxylate (ACC) deaminase, respectively...
  63. Chadwick M, Gawthrop F, Michelmore R, Wagstaff C, Methven L. Perception of bitterness, sweetness and liking of different genotypes of lettuce. Food Chem. 2016;197:66-74 pubmed publisher
    ..serriola acc. UC96US23) and domesticated lettuce (L. sativa, cv. Salinas)...
  64. Kim S, Bang C, Guo Y, Choung S. Anti-Obesity Effects of Aster spathulifolius Extract in High-Fat Diet-Induced Obese Rats. J Med Food. 2016;19:353-64 pubmed publisher
    ..g., SREBP-1c, ACC1, FAS, SCD1, GPATR, AGPAT, and DGAT)...
  65. Park J, Yeom M, Hahm D. Fucoidan improves serum lipid levels and atherosclerosis through hepatic SREBP-2-mediated regulation. J Pharmacol Sci. 2016;131:84-92 pubmed publisher
    ..In HepG2 hepatocytes and the liver, fucoidan decreased the expression of FAS and ACC mRNA with no or only a moderate inhibitory effect on SREBP-1c mRNA expression...
  66. Yilmaz M, Atar I, Hasirci S, Akyol K, Tekin A, Karacaglar E, et al. Comparison of application of 2013 ACC/AHA guideline and 2011 European Society of Cardiology guideline for the management of dyslipidemias for primary prevention in a Turkish cohort. Anatol J Cardiol. 2017;17:92-96 pubmed publisher
    ..article analyzes and compares the application of 2013 American College of Cardiology/American Heart Association (ACC/AHA) guideline and the 2011 European Society of Cardiology (ESC) guideline for the management of dyslipidemias for ..
  67. Wiley R, Kalgi A, Reich R, Freedman P. Histologic and immunohistochemical identification of cribriform adenocarcinoma. Oral Surg Oral Med Oral Pathol Oral Radiol. 2017;124:45-51 pubmed publisher
    ..tumors originally classified as adenocarcinoma not otherwise specified (Adca-NOS), adenoid cystic carcinoma (ACC), and polymorphous low-grade adenocarcinoma (PLGA) could be reclassified as cribriform adenocarcinoma of the tongue ..
  68. Taylor D, Ghataore L, Couchman L, Vincent R, Whitelaw B, Lewis D, et al. A 13-Steroid Serum Panel Based on LC-MS/MS: Use in Detection of Adrenocortical Carcinoma. Clin Chem. 2017;: pubmed publisher
    Adrenocortical carcinoma (ACC) is a rare malignancy, with an annual incidence of 1 or 2 cases per million...
  69. Gottmann P, Ouni M, Saussenthaler S, Roos J, Stirm L, Jähnert M, et al. A computational biology approach of a genome-wide screen connected miRNAs to obesity and type 2 diabetes. Mol Metab. 2018;11:145-159 pubmed publisher
    ..Manipulation of miR-31 in human SGBS adipocytes affected the expression of GLUT4, PPAR?, IRS1, and ACACA. In human peripheral blood mononuclear cells (PBMC) miR-15b levels were correlated to baseline blood glucose ..
  70. Bos P, Hofman D, Hermans E, Montoya E, Baron Cohen S, van Honk J. Testosterone reduces functional connectivity during the 'Reading the Mind in the Eyes' Test. Psychoneuroendocrinology. 2016;68:194-201 pubmed publisher
    ..in 16 young women significantly altered connectivity of the left IFG with the anterior cingulate cortex (ACC) and the supplementary motor area (SMA) during RMET performance, independent of 2D:4D ratio...
  71. Tabrizi R, Aliabadi E, Maleki M, Barouj M. Association between clinical features, treatment, and recurrence rate of adenoid cystic carcinoma of the palate: a 10-year retrospective study. Br J Oral Maxillofac Surg. 2016;54:648-51 pubmed publisher
    Adenoid cystic carcinoma (ACC) is both invasive and clinically unpredictable, and our aim was to evaluate the factors that affect its recurrence in the palate...
  72. de Oliveira Santana K, Lelis D, Mendes K, Lula J, Paraíso A, Andrade J, et al. Metformin Reduces Lipogenesis Markers in Obese Mice Fed a Low-Carbohydrate and High-Fat Diet. Lipids. 2016;51:1375-1384 pubmed
    ..sterol regulatory element-binding protein 1 (SREBP1), fatty acid synthase (FAS) and acetyl-CoA carboxylase (ACC), were assessed by RT-PCR...
  73. Bishop J, Yonescu R, Epstein J, Westra W. A subset of prostatic basal cell carcinomas harbor the MYB rearrangement of adenoid cystic carcinoma. Hum Pathol. 2015;46:1204-8 pubmed publisher
    Adenoid cystic carcinoma (ACC) is a basaloid tumor consisting of myoepithelial and ductal cells typically arranged in a cribriform pattern...
  74. Goncalves P, Heilbrun L, Barrett M, Kummar S, Hansen A, Siu L, et al. A phase 2 study of vorinostat in locally advanced, recurrent, or metastatic adenoid cystic carcinoma. Oncotarget. 2017;8:32918-32929 pubmed publisher
    ..Based on a confirmed partial response (PR) in an adenoid cystic carcinoma (ACC) patient treated with vorinostat in a prior phase 1 trial, we initiated this phase 2 trial...
  75. Patel D, Thompson M, Manna S, Krausz K, Zhang L, Nilubol N, et al. Unique and Novel Urinary Metabolomic Features in Malignant versus Benign Adrenal Neoplasms. Clin Cancer Res. 2017;23:5302-5310 pubmed publisher
    b>Purpose: Adrenal incidentalomas must be differentiated from adrenocortical cancer (ACC). Currently, size, growth, and imaging characteristics determine the potential for malignancy but are imperfect...
  76. Inohara T, Kimura T, Ueda I, Ikemura N, Tanimoto K, Nishiyama N, et al. Effect of Compliance to Updated AHA/ACC Performance and Quality Measures Among Patients With Atrial Fibrillation on Outcome (from Japanese Multicenter Registry). Am J Cardiol. 2017;120:595-600 pubmed publisher
    ..There remains an important opportunity to improve the quality of care in patients with AF. Adherence to the AF PMs might lead to the improvement of patient's quality of life. ..
  77. de la Torre González A, Navarro León E, Albacete A, Blasco B, Ruiz J. Study of phytohormone profile and oxidative metabolism as key process to identification of salinity response in tomato commercial genotypes. J Plant Physiol. 2017;216:164-173 pubmed publisher
    ..On the other hand, a lower ACC concentration, ethylene precursor, combined with a greater O2.- detoxification in the cv...
  78. Grignon D, Ro J, Ordonez N, Ayala A, Cleary K. Basal cell hyperplasia, adenoid basal cell tumor, and adenoid cystic carcinoma of the prostate gland: an immunohistochemical study. Hum Pathol. 1988;19:1425-33 pubmed
    ..BCH, one case of an unusual adenoid basal cell tumor (ABT), and one case of a prostatic adenoid cystic carcinoma (ACC), using a panel of antibodies to define the histogenesis of these lesions...
  79. Korobeinikova E, Myrzaliyeva D, Ugenskiene R, Raulinaityte D, Gedminaitė J, Smigelskas K, et al. The prognostic value of IL10 and TNF alpha functional polymorphisms in premenopausal early-stage breast cancer patients. BMC Genet. 2015;16:70 pubmed publisher
    ..017). Phased ACC haplotype of IL10 polymorphisms was associated with younger age of diagnosis (P = 0.017)...
  80. Papathomas T, Duregon E, Korpershoek E, Restuccia D, van Marion R, Cappellesso R, et al. Sarcomatoid adrenocortical carcinoma: a comprehensive pathological, immunohistochemical, and targeted next-generation sequencing analysis. Hum Pathol. 2016;58:113-122 pubmed publisher
    ..Thirteen pathogenic variants of ACC-associated TP53 and CTNNB1 genes were detected in epithelial and/or nonepithelial components in 4 out of 6 tumors...
  81. He W, Jia C. EnhancerPred2.0: predicting enhancers and their strength based on position-specific trinucleotide propensity and electron-ion interaction potential feature selection. Mol Biosyst. 2017;13:767-774 pubmed publisher
    ..from EIIP yielded the best performance for identifying enhancers and non-enhancers, with an overall accuracy (Acc) of 88.27% and a Matthews correlation coefficient (MCC) of 0.77...
  82. Pezzani R, Rubin B, Bertazza L, Redaelli M, Barollo S, Monticelli H, et al. The aurora kinase inhibitor VX-680 shows anti-cancer effects in primary metastatic cells and the SW13 cell line. Invest New Drugs. 2016;34:531-40 pubmed publisher
    ..AKI Vx-680 are useless in the H295R cell model, and therefore should not be considered as potential treatments for ACC. Serine/threonine AK inhibition, essentially with VX-680, could be a promising, specific therapeutic tool for ..
  83. Lin D, Kao S, Ho C, Wei Y, Hung P, Hsu M, et al. Inflexibility of AMPK-mediated metabolic reprogramming in mitochondrial disease. Oncotarget. 2017;8:73627-73639 pubmed publisher
    ..The aberrant secondary cellular responses to disrupted metabolic homeostasis mediated by AMPK signaling pathway may contribute to the development of the clinical phenotype...
  84. Johansen L, Naumanen T, Knudsen A, Westerlund N, Gromova I, Junttila M, et al. IKAP localizes to membrane ruffles with filamin A and regulates actin cytoskeleton organization and cell migration. J Cell Sci. 2008;121:854-64 pubmed publisher
    ..These results provide evidence for the role of the cytosolic interactions of IKAP in cell adhesion and migration, and support the notion that cell-motility deficiencies could contribute to FD. ..
  85. Peng Y, Lei T, Yuan J, Chen X, Long Q, Zhang J, et al. Arachidonic acid induces acetyl-CoA carboxylase 1 expression via activation of CREB1. Endocrine. 2009;36:491-7 pubmed publisher
    ..In animals, there are two major isoforms of ACCs, ACC1 and ACC2, which are encoded by different genes and display distinct tissue and cellular distribution...
  86. Galdieri L, Gatla H, Vancurova I, Vancura A. Activation of AMP-activated Protein Kinase by Metformin Induces Protein Acetylation in Prostate and Ovarian Cancer Cells. J Biol Chem. 2016;291:25154-25166 pubmed
    ..AMPK phosphorylates and inhibits acetyl-CoA carboxylase (ACC), which catalyzes carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting reaction in de novo ..
  87. Kalra A, Glusenkamp N, Anderson K, Kalra R, Kerkar P, Kumar G, et al. American College of Cardiology (ACC)'s PINNACLE India Quality Improvement Program (PIQIP)-Inception, progress and future direction: A report from the PIQIP Investigators. Indian Heart J. 2016;68 Suppl 3:S1-S4 pubmed publisher
    ..sup>5 This manuscript discusses the inception of the PIQIP registry, the progress it has made and challenges thus far, and its future direction and the promise it holds for cardiovascular care quality improvement in India. ..
  88. Zundler S, Strobel D, Manger B, Neurath M, Wildner D. Pancreatic Panniculitis and Polyarthritis. Curr Rheumatol Rep. 2017;19:62 pubmed publisher
    ..g., acute or chronic pancreatitis) or malign (e.g., acinar cell carcinoma (ACC) or adenocarcinoma) pancreatic disease...
  89. Mass T, Giuffre A, Sun C, Stifler C, Frazier M, Neder M, et al. Amorphous calcium carbonate particles form coral skeletons. Proc Natl Acad Sci U S A. 2017;114:E7670-E7678 pubmed publisher
    ..corals that two amorphous precursors exist, one hydrated and one anhydrous amorphous calcium carbonate (ACC); that these are formed in the tissue as 400-nm particles; and that they attach to the surface of coral skeletons, ..
  90. Jiang M, Ding H, Li C, Xiang K, Tang J, Guo Y, et al. Surgical resection of adrenocortical carcinoma with invasion into the inferior vena cava: a case report and literature review. Clin Case Rep. 2017;5:1934-1937 pubmed publisher
    Adrenocortical carcinoma (ACC) is a malignant endocrine tumor. Moreover, ACC with invasion into the inferior vena cava is rare. Early diagnosis and treatment are crucial for such cases...
  91. Lipka A, Majewska M, Panasiewicz G, Bieniek Kobuszewska M, Szafranska B. Gene structure of the pregnancy-associated glycoprotein-like (PAG-L) in the Eurasian beaver (Castor fiber L.). Funct Integr Genomics. 2017;17:599-605 pubmed publisher
    ..named CfPAG-L. We identified 7657 bp of the CfPAG-L gDNA sequence (Acc. No. KX377932), encompassing nine exons (1-9) and eight introns (A-H)...
  92. Milton Laskibar I, Aguirre L, Fernández Quintela A, Rolo A, Soeiro Teodoro J, Palmeira C, et al. Lack of Additive Effects of Resveratrol and Energy Restriction in the Treatment of Hepatic Steatosis in Rats. Nutrients. 2017;9: pubmed publisher
    ..CPT1a, CS, COX, SDH and ATP synthase activities, FATP2/FATP5, DGAT2, PPARα, SIRT1, UCP2 protein expressions, ACC and AMPK phosphorylation and PGC1α deacetylation...