Gene Symbol: ACAA1
Description: acetyl-CoA acyltransferase 1
Alias: ACAA, PTHIO, THIO, 3-ketoacyl-CoA thiolase, peroxisomal, acetyl-Coenzyme A acyltransferase 1, beta-ketothiolase, peroxisomal 3-oxoacyl-CoA thiolase, peroxisomal 3-oxoacyl-Coenzyme A thiolase, testicular tissue protein Li 197
Species: human
Products:     ACAA1

Top Publications

  1. Förster D, Reiser G. Nucleotides protect rat brain astrocytes against hydrogen peroxide toxicity and induce antioxidant defense via P2Y receptors. Neurochem Int. 2016;94:57-66 pubmed publisher
    ..We determined the influence of treatment with the P2Y1 receptor-specific agonist 2-methyl-thio-ADP (2MeSADP) and the broad range P2Y receptor agonist adenosine 5'-(3-thiotriphosphate) (ATPγS)...
  2. Liu C, Bonaventure P, Lee G, Nepomuceno D, Kuei C, Wu J, et al. GPR139, an Orphan Receptor Highly Enriched in the Habenula and Septum, Is Activated by the Essential Amino Acids L-Tryptophan and L-Phenylalanine. Mol Pharmacol. 2015;88:911-25 pubmed publisher
    ..GPR139 activity was measured using guanosine 5'-O-(3-[(35)S]thio)-triphosphate binding, calcium mobilization, and extracellular signal-regulated kinases phosphorylation assays...
  3. Liñán Rico A, Wunderlich J, Grants I, Frankel W, Xue J, Williams K, et al. Purinergic autocrine regulation of mechanosensitivity and serotonin release in a human EC model: ATP-gated P2X3 channels in EC are downregulated in ulcerative colitis. Inflamm Bowel Dis. 2013;19:2366-79 pubmed publisher
    ..ARL67156 augmented and apyrase blocked Ca/5-HT mechanosensitive responses. 2-Methyl-thio-adenosine diphosphate 5'-monophosphate-evoked (P2Y1,12) or mechanically-evoked responses were blocked or augmented ..
  4. Čolović M, Vasić V, Avramović N, Gajić M, Djurić D, Krstić D. In vitro evaluation of neurotoxicity potential and oxidative stress responses of diazinon and its degradation products in rat brain synaptosomes. Toxicol Lett. 2015;233:29-37 pubmed publisher
    ..These studies mostly include thio forms, while the effects of their metabolites/degradation products have been less investigated...
  5. Wakita H, Yanagawa T, Kuboi Y, Imai T. E6130, a Novel CX3C Chemokine Receptor 1 (CX3CR1) Modulator, Attenuates Mucosal Inflammation and Reduces CX3CR1+ Leukocyte Trafficking in Mice with Colitis. Mol Pharmacol. 2017;92:502-509 pubmed publisher
    ..E6130 had agonistic activity via CX3CR1 with respect to guanosine 5'-3-O-(thio)triphosphate binding in CX3CR1-expressing Chinese hamster ovary K1 (CHO-K1) membrane and had no antagonistic ..
  6. Cureton N, Korotkova I, Baker B, Greenwood S, Wareing M, Kotamraju V, et al. Selective Targeting of a Novel Vasodilator to the Uterine Vasculature to Treat Impaired Uteroplacental Perfusion in Pregnancy. Theranostics. 2017;7:3715-3731 pubmed publisher
    ..The nitric oxide donor 2-[[4-[(nitrooxy)methyl]benzoyl]thio]-benzoic acid methyl ester (SE175) induced significant relaxation of mouse uterine arteries and human placental ..
  7. Fidelis P, Wilson L, Thomas K, Villalobos M, Oyekan A. Renal function and vasomotor activity in mice lacking the Cyp4a14 gene. Exp Biol Med (Maywood). 2010;235:1365-74 pubmed publisher
    ..Renal vascular responses to guanosine 5'-O-(gamma-thio)triphosphate, a non-hydrolyzable GTP analog, or NaF(4), an activator of G-proteins, were also enhanced...
  8. Kalvass J, Olson E, Cassidy M, Selley D, Pollack G. Pharmacokinetics and pharmacodynamics of seven opioids in P-glycoprotein-competent mice: assessment of unbound brain EC50,u and correlation of in vitro, preclinical, and clinical data. J Pharmacol Exp Ther. 2007;323:346-55 pubmed
    ..of opioid binding affinity (Ki) and functional activity [EC50 for agonist stimulated guanosine 5'-O-(3-[35S]thio)triphosphate binding] and relevant clinical parameters were obtained to construct in vitro-to-preclinical and ..
  9. Park Y, Jung B, Hong S, Park G, Ibal J, Pham H, et al. Expression and Characterization of Calcium- and Zinc-Tolerant Xylose Isomerase from Anoxybacillus kamchatkensis G10. J Microbiol Biotechnol. 2018;28:606-612 pubmed publisher
    ..The expression of recombinant XI was induced in the absence of isopropyl-thio-?-galactopyranoside and purified using Ni-NTA affinity chromatography...

More Information

Publications150 found, 100 shown here

  1. Liu C, Fan D, Li Y, Chen Y, Huang L, Yan X. Transcriptome analysis of Valsa mali reveals its response mechanism to the biocontrol actinomycete Saccharothrix yanglingensis Hhs.015. BMC Microbiol. 2018;18:90 pubmed publisher
    ..and superoxide dismutase (SOD) which scavenge reactive oxygen species (ROS), as well as those encoding AMACR and ACAA1 which are related to the β-oxidation of fatty acids, were down-regulated...
  2. Romero M, Jimenez R, Toral M, León Gómez E, Gómez Guzmán M, Sanchez M, et al. Vascular and Central Activation of Peroxisome Proliferator-Activated Receptor-? Attenuates Angiotensin II-Induced Hypertension: Role of RGS-5. J Pharmacol Exp Ther. 2016;358:151-63 pubmed publisher
    ..five groups (control mice, PPAR? agonist [4-[[[2-[3-Fluoro-4-(trifluoromethyl)phenyl]-4-methyl-5-thiazolyl]methyl]thio]-2-methylphenoxy]acetic acid (GW0742)-treated mice AngII-infused mice, GW0742-treated AngII-infused mice, and AngII-..
  3. Morjan R, Al Attar N, Abu Teim O, Ulrich M, Awadallah A, Mkadmh A, et al. Synthesis, antibacterial and QSAR evaluation of 5-oxo and 5-thio derivatives of 1,4-disubstituted tetrazoles. Bioorg Med Chem Lett. 2015;25:4024-8 pubmed publisher
    ..The concluded cross validated regression factors are 0.953 and 0.986 for E. coli, and S. aureus, respectively. ..
  4. Yuan S, Hollinger M, Lachowicz Scroggins M, Kerr S, Dunican E, Daniel B, et al. Oxidation increases mucin polymer cross-links to stiffen airway mucus gels. Sci Transl Med. 2015;7:276ra27 pubmed publisher
    ..We therefore synthesized a thiol-carbohydrate structure (methyl 6-thio-6-deoxy-α-D-galactopyranoside) and found that it had stronger reducing activity than NAC and more potent and ..
  5. Hu X, Chandler J, Orr M, Hao L, Liu K, Uppal K, et al. Selenium Supplementation Alters Hepatic Energy and Fatty Acid Metabolism in Mice. J Nutr. 2018;148:675-684 pubmed publisher
    ..the other centered on the transcripts for carnitine-palmitoyl transferase 2 (Cpt2) and acetyl-CoA acyltransferase (Acaa1). Pathway analysis showed that highly associated metabolites (P < 0...
  6. Takahashi S, Iizumi T, Mashima K, Abe T, Suzuki N. Roles and regulation of ketogenesis in cultured astroglia and neurons under hypoxia and hypoglycemia. ASN Neuro. 2014;6: pubmed publisher
    ..The 4- to 24-hr production of AA and BHB was measured using the cyclic thio-NADH method. (14)C-labeled acid-soluble products (KBs) and (14)CO2 produced from [1-(14)C]PAL were also measured...
  7. Algarni A, Hargreaves A, Dickenson J. Activation of transglutaminase 2 by nerve growth factor in differentiating neuroblastoma cells: A role in cell survival and neurite outgrowth. Eur J Pharmacol. 2018;820:113-129 pubmed publisher
    ..and R283 (1,3,dimethyl-2[2-oxo-propyl]thio)imidazole chloride) and by pharmacological inhibition of extracellular signal-regulated kinases 1 and 2 (ERK1/2), ..
  8. Miran T, Vogg A, Drude N, Mottaghy F, Morgenroth A. Modulation of glutathione promotes apoptosis in triple-negative breast cancer cells. FASEB J. 2018;: pubmed publisher
    ..GSH depletion to sensitize CSCs to ionizing radiotherapy with an I-125-labeled nucleoside analog, 5-iodo-4'-thio-2'-deoxyuridine (ITdU). CSCs were isolated using CD24-- and CD44+-specific microbeads...
  9. Luzina I, Lockatell V, Todd N, Kopach P, Pentikis H, Atamas S. Pharmacological In Vivo Inhibition of S-Nitrosoglutathione Reductase Attenuates Bleomycin-Induced Inflammation and Fibrosis. J Pharmacol Exp Ther. 2015;355:13-22 pubmed publisher
    ..of administration of a pharmacological inhibitor of S-nitrosoglutathione reductase, SPL-334 (4-{[2-[(2-cyanobenzyl)thio]-4-oxothieno[3,2-d]pyrimidin-3(4H)-yl]methyl}benzoic acid), in a mouse model of ILD induced by intratracheal ..
  10. Matsushita Y, Manabe M, Kitamura N, Shibuya I. Adrenergic receptors inhibit TRPV1 activity in the dorsal root ganglion neurons of rats. PLoS ONE. 2018;13:e0191032 pubmed publisher
    ..with pertussis toxin (100 μg/ml for 24 h) and the neurons dialyzed intracellularly with guanosine 5'- [β-thio] diphosphate (GDPβS, 200 μM), the catalytic subunit of protein kinase A (250 U/ml) or okadaic acid (1 μM)...
  11. Joachim I, Rikker S, Hauck D, Ponader D, Boden S, Sommer R, et al. Development and optimization of a competitive binding assay for the galactophilic low affinity lectin LecA from Pseudomonas aeruginosa. Org Biomol Chem. 2016;14:7933-48 pubmed publisher
    ..Finally, we employed the optimized assay to screen sets of synthetic thio-galactosides and natural blood group antigens and report their structure-activity relationship...
  12. Czubatka Bieńkowska A, Sarnik J, Macieja A, Galita G, Witczak Z, Poplawski T. Thio-functionalized carbohydrate thiosemicarbazones and evaluation of their anticancer activity. Bioorg Med Chem Lett. 2017;27:2713-2720 pubmed publisher
    ..Upregulation of heat shock protein encoding genes suggest that our compounds induce stressful conditions. The nature of this phenomena (heat shock, pH shift or hypoxia) needs further study. ..
  13. Barreda Gómez G, Lombardero L, Giralt M, Manuel I, Rodríguez Puertas R. Effects of galanin subchronic treatment on memory and muscarinic receptors. Neuroscience. 2015;293:23-34 pubmed publisher
    ..quantify the density of muscarinic receptors (MRs) and the stimulation of the binding of guanosine 5'-(γ-[(35)S]thio)triphosphate by the muscarinic agonist, carbachol, to determine their functionality...
  14. Duwel M, Ungewickell E. Clathrin-dependent association of CVAK104 with endosomes and the trans-Golgi network. Mol Biol Cell. 2006;17:4513-25 pubmed
    ..Recruitment of CVAK104 to perinuclear membranes of permeabilized cells is enhanced by guanosine 5'-O-(3-thio)triphosphate, and brefeldin A redistributes CVAK104 in cells...
  15. Yang Z, Bochkov Y, Voelker D, Foster M, Que L. Identification of a Novel Inhibitor of HRV Replication and Inflammation in Airway Epithelial Cells. Am J Respir Cell Mol Biol. 2018;: pubmed publisher
    ..cells, we found that treatment with a previously-characterized GSNOR inhibitor (4-[[2-[[(3-cyanophenyl)methyl]thio]-4-oxothieno-[3,2-d]pyrimidin-3(4H)-yl]methyl]-benzoic acid; referred to as C3m) decreased RV-A16 replication and ..
  16. Burger P, Williams M, Sprenger J, Reeksting S, Botha M, Müller I, et al. A novel inhibitor of Plasmodium falciparum spermidine synthase: a twist in the tail. Malar J. 2015;14:54 pubmed publisher
    ..value of compound 9 is in the same range as that of the most potent inhibitors of PfSpdS, S-adenosyl-1,8-diamino-3-thio-octane (AdoDATO) and 4MCHA and 100-fold lower than that of compound 8...
  17. Hahn Y, Paris J, Lichtman A, Hauser K, Sim Selley L, Selley D, et al. Central HIV-1 Tat exposure elevates anxiety and fear conditioned responses of male mice concurrent with altered mu-opioid receptor-mediated G-protein activation and β-arrestin 2 activity in the forebrain. Neurobiol Dis. 2016;92:124-36 pubmed publisher
    ..G-protein activation was assessed by MOR agonist-stimulated [(35)S]guanosine-5'-O-(3-thio)triphosphate ([(35)S]GTPγS) autoradiography in brain sections, and in concentration-effect curves of MOR agonist-..
  18. Isaac I, Al Rashida M, Rahman S, Alharthy R, Asari A, Hameed A, et al. Acridine-based (thio)semicarbazones and hydrazones: Synthesis, in vitro urease inhibition, molecular docking and in-silico ADME evaluation. Bioorg Chem. 2019;82:6-16 pubmed publisher
    ..In search of new molecules with better urease inhibitory activity, herein we report a series of acridine derived (thio)semicarbazones (4a-4e, 6a-6l) that were found to be active against urease enzyme...
  19. Morvay P, Baes M, Van Veldhoven P. Differential activities of peroxisomes along the mouse intestinal epithelium. Cell Biochem Funct. 2017;35:144-155 pubmed publisher
    ..Other peroxisomal enzymes (PHYH, HACL1, and ACAA1), the ABCD2 and ABCD3 transporters, and peroxins PEX13 and PEX14, however, did not follow this pattern, displaying ..
  20. Zhang Y, Liu F, Xiao H, Yao X, Li G, Choi S, et al. Fluorine-18 labeled diphenyl sulfide derivatives for imaging serotonin transporter (SERT) in the brain. Nucl Med Biol. 2018;66:1-9 pubmed publisher
    ..Among them, 2-((2-((dimethylamino)-methyl)-4-(2-(2-fluoroethoxy)ethoxy)phenyl)thio)aniline, 1, which showed excellent binding toward serotonin transporter (SERT) in the brain (Ki = 0...
  21. Witkin J, Mitchell S, Wafford K, Carter G, Gilmour G, Li J, et al. Comparative Effects of LY3020371, a Potent and Selective Metabotropic Glutamate (mGlu) 2/3 Receptor Antagonist, and Ketamine, a Noncompetitive N-Methyl-d-Aspartate Receptor Antagonist in Rodents: Evidence Supporting the Use of mGlu2/3 Antagonists, fo. J Pharmacol Exp Ther. 2017;361:68-86 pubmed publisher
  22. MacDonald J, Sutherland C, Carlson D, Bhaidani S, Al Ghabkari A, Swärd K, et al. A Small Molecule Pyrazolo[3,4-d]Pyrimidinone Inhibitor of Zipper-Interacting Protein Kinase Suppresses Calcium Sensitization of Vascular Smooth Muscle. Mol Pharmacol. 2016;89:105-17 pubmed publisher
    ..pyrazolo[3,4-d]pyrimidinone inhibitor 2-((1-(3-chlorophenyl)-4-oxo-4,5-dihydro-1H-pyrazolo [3,4-d]-pyrimidin-6-yl)thio)propanamide (HS38) decreased the velocity of contraction (time to reach half-maximal force) induced by the ..
  23. Zitta K, Meybohm P, Gruenewald M, Cremer J, Zacharowski K, Scholz J, et al. Profiling of cell stress protein expression in cardiac tissue of cardiosurgical patients undergoing remote ischemic preconditioning: implications for thioredoxin in cardioprotection. J Transl Med. 2015;13:34 pubmed publisher
    ..Cell stress proteome profiler arrays as well as Westernblotting and ELISA experiments for thioredoxin (Thio-1) were performed employing the respective tissue samples. Protein arrays revealed an up-regulation of 26...
  24. Mochalski P, Diem E, Unterkofler K, Mündlein A, Drexel H, Mayhew C, et al. In vitro profiling of volatile organic compounds released by Simpson-Golabi-Behmel syndrome adipocytes. J Chromatogr B Analyt Technol Biomed Life Sci. 2019;1104:256-261 pubmed publisher
    ..ethyl methyl sulphide and dimethyl disulphide), three heterocyclic compounds (2-ethylfuran, 2-methyl-5-(methyl-thio)-furan, and 2-pentylfuran), two ketones (acetone and 2-pentanone), two hydrocarbons (isoprene and n-heptane) and ..
  25. Li W, Liu J, Chen J, Zhu Y, Gao X, Ni Y, et al. Neuroprotective Effects of DTIO, A Novel Analog of Nec-1, in Acute and Chronic Stages After Ischemic Stroke. Neuroscience. 2018;390:12-29 pubmed publisher
    ..Recently, our group synthesized a novel analog of Nec-1, 5-(3',5'-dimethoxybenzal)-2-thio-imidazole-4-ketone (DTIO)...
  26. Abd Rahman S, Ariffin N, Yusof N, Abdullah J, Mohammad F, Ahmad Zubir Z, et al. Thiolate-Capped CdSe/ZnS Core-Shell Quantum Dots for the Sensitive Detection of Glucose. Sensors (Basel). 2017;17: pubmed publisher
    ..a room temperature ligand-exchange method that involves six organic ligands, L-cysteine, L-histidine, thio-glycolic acid (TGA or mercapto-acetic acid, MAA), mercapto-propionic acid (MPA), mercapto-succinic acid (MSA), and ..
  27. Alonso Rodríguez E, Fernández Piñar P, Sacristán Reviriego A, Molina M, Martín H. An Analog-sensitive Version of the Protein Kinase Slt2 Allows Identification of Novel Targets of the Yeast Cell Wall Integrity Pathway. J Biol Chem. 2016;291:5461-72 pubmed publisher
    ..We demonstrated that Slt2-as is able to use adenosine 5'-[γ-thio]triphosphate analogs to thiophosphorylate its substrates in yeast cell extracts as well as when produced as ..
  28. Mascia P, Pistis M, Justinova Z, Panlilio L, Luchicchi A, Lecca S, et al. Blockade of nicotine reward and reinstatement by activation of alpha-type peroxisome proliferator-activated receptors. Biol Psychiatry. 2011;69:633-41 pubmed publisher
    ..approaches to evaluate effects of the PPAR-α agonists [[4-Chloro-6-[(2,3-dimethylphenyl)amino]-2-pyrimidinyl]thio]acetic acid (WY14643) and methyl oleoylethanolamide (methOEA; a long-lasting form of OEA) on 1) nicotine self-..
  29. Overland A, Insel P. Heterotrimeric G proteins directly regulate MMP14/membrane type-1 matrix metalloprotease: a novel mechanism for GPCR-EGFR transactivation. J Biol Chem. 2015;290:9941-7 pubmed publisher
    ..we found that MMP14 activity is increased by angiotensin II, phenylephrine, GTP, and guanosine 5'-O-[γ-thio]triphosphate (GTPγS)...
  30. Vyas F, Nelson C, Freeman F, Boocock D, Hargreaves A, Dickenson J. β2-adrenoceptor-induced modulation of transglutaminase 2 transamidase activity in cardiomyoblasts. Eur J Pharmacol. 2017;813:105-121 pubmed publisher
    ..and R283 ((1,3,dimethyl-2[2-oxo-propyl]thio)imidazole chloride)...
  31. József J, Juhász L, Illyés T, Csávás M, Borbás A, Somsák L. Photoinitiated hydrothiolation of pyranoid exo-glycals: the d-galacto and d-xylo cases. Carbohydr Res. 2015;413:63-9 pubmed publisher
    ..of the corresponding β-d-glycopyranosylmethyl-sulfide derivatives (2,6-anhydro-1-deoxy-1-S-substituted-1-thio-alditols) with exclusive regio- and very high stereoselectivity, including disaccharide mimicks with Gly-CH2-S-Gly ..
  32. Shim J, Lee S, Gim H, Kim H, Han T, Kim J, et al. Regulation of the pacemaker activities in cultured interstitial cells of Cajal by Citrus unshiu peel extracts. Mol Med Rep. 2016;14:3908-16 pubmed publisher
    ..When the pipette solution contained guanosine 5'-(?-thio) diphosphate trilithium salt (1 mM), CPE marginally induced membrane pacemaker depolarization...
  33. Onwudiwe D, Hrubaru M, Hosten E, Arderne C. Bis(?-N,N-di-allyl-dithio-carbamato)bis[(N,N-di-allyl-dithio-carbamato)cadmium]. Acta Crystallogr E Crystallogr Commun. 2017;73:1353-1356 pubmed publisher a neutral dinuclear cadmium(II) complex bearing four bis N,N-di-allyl-di-thio-carbamate ligands coordinating to two CdII cations...
  34. Valldor M, Rößler U, Prots Y, Kuo C, Chiang J, Hu Z, et al. Synthesis and Characterization of Ba[CoSO]: Magnetic Complexity in the Presence of Chalcogen Ordering. Chemistry. 2015;21:10821-8 pubmed publisher
    Barium thio-oxocobaltate(II), Ba[CoS2/2 O2/2 ], was synthesized by the reaction of equimolar amounts of BaO, Co, and S in closed silica ampoules. The title compound (Cmcm, a=3.98808(3), b=12.75518(9), c=6...
  35. Wang W, Peng X, Wei F, Tung C, Xu Z. Copper(I)-Catalyzed Interrupted Click Reaction: Synthesis of Diverse 5-Hetero-Functionalized Triazoles. Angew Chem Int Ed Engl. 2016;55:649-53 pubmed publisher
    ..Various 5-amino-, thio-, and selenotriazoles were readily assembled in one step in high yields...
  36. Feng Y, Ying H, Qu Y, Cai X, Xu M, Lu L. Novel matrine derivative MD-1 attenuates hepatic fibrosis by inhibiting EGFR activation of hepatic stellate cells. Protein Cell. 2016;7:662-72 pubmed publisher
    ..In the present study, we report a more effective thio derivative of MT, MD-1, and its inhibitory effects on the activation of hepatic stellate cells (HSCs) in both cell ..
  37. Blain M, Yau H, Jean Gérard L, Auvergne R, Benazet D, Schreiner P, et al. Urea- and Thiourea-Catalyzed Aminolysis of Carbonates. ChemSusChem. 2016;9:2269-72 pubmed publisher
    ..In addition, we demonstrate a medium-range pKa of the (thio)urea and an unqeual substitution pattern is critical for controlling the efficiency of the carbonate opening.
  38. Croce M, Conti S, Maake C, Patzke G. Synthesis and screening of N-acyl thiolated chitosans for antibacterial applications. Carbohydr Polym. 2016;151:1184-1192 pubmed publisher
    ..relationships of newly synthesized alkyl thiomers, chitosan has been functionalized with a series of thio-acids with increasing alkyl chain length...
  39. Liu X, Yu B, Huang Q, Liu R, Feng Q, Cai Q, et al. In vitro BMP-2 peptide release from thiolated chitosan based hydrogel. Int J Biol Macromol. 2016;93:314-321 pubmed publisher
    ..In the present study, a kind of thiolated chitosan, i.e. chitosan-4-thio-butylamidine (CS-TBA) conjugate was characterized and used to prepare CS-TBA/hydroxyapatite (HA)/beta-..
  40. Chang X, Xiao P, Han J, Fang W, Cui G. A theoretical study of the light-induced cross-linking reaction of 5-fluoro-4-thiouridine with thymine. Phys Chem Chem Phys. 2017;19:13524-13533 pubmed publisher
    In contrast to photophysics of thio-substituted nucleobases, their photoinduced cross-linking reactions with canonical nucleobases remain scarcely investigated computationally...
  41. Chang Y, Hector A, Levason W, Reid G. Chalcogenoether complexes of Nb(v) thio- and seleno-halides as single source precursors for low pressure chemical vapour deposition of NbS2 and NbSe2 thin films. Dalton Trans. 2017;46:9824-9832 pubmed publisher
    ..The thin films were characterised by grazing incidence and in-plane XRD, pole figure analysis, scanning electron microscopy and energy dispersive X-ray analysis. ..
  42. Zhang Y, Wang P, Lin S, Mercier Y, Yin H, Song Y, et al. mTORC1 signaling-associated protein synthesis in porcine mammary glands was regulated by the local available methionine depending on methionine sources. Amino Acids. 2018;50:105-115 pubmed publisher
    ..of L-methionine (L-MET), D-methionine (D-MET), DL-2-hydroxy-4-(methylthio) butyric acid (HMTBA), or keto-methyl(thio)butanoic acid (KMB)...
  43. Lohar S, Sinha S, Ghosh S, Das D. Tri-color emission and colorimetric recognition of acetate using semicarbazide and thio-semicarbazide derivatives: Experimental and computational studies. Spectrochim Acta A Mol Biomol Spectrosc. 2016;155:75-80 pubmed publisher
    Two new fluorescence probes having semicarbazide (DSC) and thio-semicarbazide (DTSC) units have been derived upon reaction with 2-hydroxy-5-methylbenzene-1,3-dialdehyde...
  44. Laffleur F, Messirek A. Development of mucoadhesive thio-carboxymethyl cellulose for application in buccal delivery of drugs. Ther Deliv. 2016;7:63-71 pubmed publisher
    ..7-fold improved mucoadhesiveness on the rotating cylinder. Chemical modification of well-known CMC encourage further evaluation and application of the mucoadhesive potential for the buccal delivery. ..
  45. Gündüz D, Tanislav C, Sedding D, Parahuleva M, Santoso S, Troidl C, et al. Uridine Triphosphate Thio Analogues Inhibit Platelet P2Y12 Receptor and Aggregation. Int J Mol Sci. 2017;18: pubmed publisher
    ..Here we characterise the effects of thio analogues of uridine triphosphate (UTP) on ADP-induced platelet aggregation...
  46. Celis N, Araos J, Sanhueza C, Toledo F, Beltrán A, Pardo F, et al. Intracellular acidification increases adenosine transport in human umbilical vein endothelial cells. Placenta. 2017;51:10-17 pubmed publisher
    ..transport kinetics (0-500 ?mol/L, 37 °C) in the absence or presence 1 or 10 ?mol/L S-(4-nitrobenzyl)-6-thio-inosine (NBTI), 2 mmol/L hypoxanthine, 2 mmol/L adenine, 100 ?mol/L 5HT, or 500 ?mol/L adenosine, was measured...
  47. Zheng C, Black K, Dos Santos P. Diverse Mechanisms of Sulfur Decoration in Bacterial tRNA and Their Cellular Functions. Biomolecules. 2017;7: pubmed publisher
    ..Considering that many of the thio-tRNA biosynthetic enzymes are absent in Gram-positive bacteria, recent studies have addressed how sulfur ..
  48. Thompson A, Blaser A, Palmer B, Anderson R, Shinde S, Launay D, et al. 6-Nitro-2,3-dihydroimidazo[2,1-b][1,3]thiazoles: Facile synthesis and comparative appraisal against tuberculosis and neglected tropical diseases. Bioorg Med Chem Lett. 2017;27:2583-2589 pubmed publisher
    ..Overall, "thio-delamanid" (49) is regarded as the best lead.
  49. Martini M, Hegger P, Schädel N, Minsky B, Kirchhof M, Scholl S, et al. Charged Triazole Cross-Linkers for Hyaluronan-Based Hybrid Hydrogels. Materials (Basel). 2016;9: pubmed publisher
    ..These cross-linkers react with thiolated hyaluronan in a fast, stoichiometric thio-Michael addition...
  50. Clayton P, Patel E, Lawson A, Carruthers R, Collins J. Bile acid profiles in peroxisomal 3-oxoacyl-coenzyme A thiolase deficiency. J Clin Invest. 1990;85:1267-73 pubmed
    ..The results provide evidence for peroxisomal pathways for cholic acid synthesis in man via THCA, delta 24-THCA and varanic acid and show that bile acid analyses can be used to diagnose peroxisomal thiolase deficiency. ..
  51. De S, Das M, Bhunia S, Bisai A. Unified Approach to the Spiro(pyrrolidinyl-oxindole) and Hexahydropyrrolo[2,3-b]indole Alkaloids: Total Syntheses of Pseudophrynamines 270 and 272A. Org Lett. 2015;17:5922-5 pubmed publisher
    ..A common strategy involving a thio-urea catalyzed aldol reaction is employed for the total synthesis of both spiro(pyrrolidinyl-oxindole) and ..
  52. Bacchi A, Nelson M, Pfeifer C. Characterization of methacrylate-based composites containing thio-urethane oligomers. Dent Mater. 2016;32:233-9 pubmed publisher
    To evaluate the ability of thio-urethane oligomers to improve the properties of restorative composite resins...
  53. Zhou M, Luo R, Hou X, Wang R, Yan G, Chen H, et al. Synthesis, biological evaluation and molecular docking study of N-(2-methoxyphenyl)-6-((4-nitrophenyl)sulfonyl)benzamide derivatives as potent HIV-1 Vif antagonists. Eur J Med Chem. 2017;129:310-324 pubmed publisher
    ..Through optimizations of the central ring of N-(2-methoxyphenyl)-2-((4-nitrophenyl)thio)benzamide (RN-18), we found a potent compound 12c with EC50 value of 1...
  54. Çavuşoğlu B, Yurttaş L, Cantürk Z. The synthesis, antifungal and apoptotic effects of triazole-oxadiazoles against Candida species. Eur J Med Chem. 2018;144:255-261 pubmed publisher
    ..krusei and C. glabrata. The compounds namely N-(4-nitrophenyl)-2-[(5-(2-((4-methyl-4H-1,2,4-triazol-3-yl)thio)ethyl)-1,3,4-oxadiazol-2-yl)thio]acetamide (4e) and N-(6-fluorobenzothiazol-2-yl)-2-[(5-(2-((4-methyl-4H-1,2,4-..
  55. Guo J, Wong J, Cui C, Li X, Yu H. A smartphone-readable barcode assay for the detection and quantitation of pesticide residues. Analyst. 2015;140:5518-25 pubmed publisher
    ..iodine to thiocholine that in turn dissociates dithiobis-nitrobenzoate to produce a yellow product (deprotonated thio-nitrobenzoate)...
  56. Kobayashi D, Ueki A, Yamaji T, Nagao K, Imamura A, Ando H, et al. Efficient Synthesis of the Lewis A Tandem Repeat. Molecules. 2016;21: pubmed publisher
    ..synthesized by stereoselective nitrile-assisted β-galactosylation with the phenyl 3-O-allyl-2,4,6-tri-O-benzyl-1-thio-β-galactoside, and ether-assisted α-fucosylation with fucosyl (N-phenyl)trifluoroacetimidate...
  57. Rosenberg J, Price J, Barcenas Morales G, Ceron Gutierrez L, Davies S, Kumararatne D, et al. Protein microarrays identify disease-specific anti-cytokine autoantibody profiles in the landscape of immunodeficiency. J Allergy Clin Immunol. 2016;137:204-213.e3 pubmed publisher
    ..samples from patients with immunodeficiency and assessed the sensitivity and specificity of protein microarrays for ACAA identification and discovery. Highly multiplexed protein microarrays were designed and fabricated...
  58. Lund J, Stensrud C, Rajender -, Bohov P, Thoresen G, Berge R, et al. The molecular structure of thio-ether fatty acids influences PPAR-dependent regulation of lipid metabolism. Bioorg Med Chem. 2016;24:1191-203 pubmed publisher
    b>Thio-ether fatty acids (THEFAs), including the parent 2-(tetradecylthio)acetic acid (TTA), are modified fatty acids (FAs) that have profound effects on lipid metabolism given that they are blocked for β-oxidation, and able to act as ..
  59. Becerra Cely L, Rueda Espinosa J, Ojeda Porras A, Gamba Sanchez D. Insights into the Pummerer synthesis of oxazolines. Org Biomol Chem. 2016;14:8474-85 pubmed publisher
    A rapid and simple method to access unnatural 2-substituted 5-thio oxazolines has been developed...
  60. Mohanty M, Ye M, Li X, Rossi N. Hypotonic swelling-induced Ca(2+) release by an IP(3)-insensitive Ca(2+) store. Am J Physiol Cell Physiol. 2001;281:C555-62 pubmed
    ..which was inhibited by 1 microM thapsigargin but not by 50 microg/ml heparin, 50 microM ruthenium red, or 25 microM thio-NADP...
  61. Nenicu A, Lüers G, Kovacs W, David M, Zimmer A, Bergmann M, et al. Peroxisomes in human and mouse testis: differential expression of peroxisomal proteins in germ cells and distinct somatic cell types of the testis. Biol Reprod. 2007;77:1060-72 pubmed
    ..Our results suggest a cell type-specific metabolic function of peroxisomes in the testis and point to an important role for peroxisomes in spermiogenesis and in the lipid metabolism of Sertoli cells. ..
  62. Moon J, Chun B, Cho Y. Hyperglycemia at presentation is associated with in hospital mortality in non-diabetic patient with organophosphate poisoning. Clin Toxicol (Phila). 2016;54:252-8 pubmed publisher
    ..ingested OPs were dichlorvos (n = 33), fenitrothion (n = 25), and ethyl p-nitrophenol thio-benzene phosphonate (EPN) (n = 24). The primary outcome was case fatality...
  63. Rodriguez Centeno J, Sastre L. Biological Activity of the Alternative Promoters of the Dictyostelium discoideum Adenylyl Cyclase A Gene. PLoS ONE. 2016;11:e0148533 pubmed publisher
    ..The gene coding for ACA (acaA) is transcribed from three different promoters that are active at different developmental stages...
  64. Artyushin O, Matveeva E, Vologzhanina A, Voloshin Y. Clathrochelates meet phosphorus. New thio- and phosphorylation reactions of an iron(II) dichloroclathrochelate precursor and preparation of its first phosphorus(III)-containing macrobicyclic derivative. Dalton Trans. 2016;45:5328-33 pubmed publisher
    ..The synthesized phosphorus(v)-containing cage complexes were characterized using elemental analysis, MALDI-TOF mass, IR, UV-Vis, (1)H, (11)B, (13)C{(1)H}, (19)F{(1)H} and (31)P{(1)H} NMR spectra, and by single-crystal X-ray diffraction. ..
  65. Vullo D, Supuran C, Scozzafava A, De Simone G, Monti S, Alterio V, et al. Kinetic and X-ray crystallographic investigations of substituted 2-thio-6-oxo-1,6-dihydropyrimidine-benzenesulfonamides acting as carbonic anhydrase inhibitors. Bioorg Med Chem. 2016;24:3643-8 pubmed publisher
    ..1.1.27) inhibitors. All compounds contain a primary sulfonamide zinc-binding group (ZBG) substituted with the 2-thio-6-oxo-1,6-dihydropyrimidine scaffold...
  66. Huang S, Song C, Wang X, Zhang G, Wang Y, Jiang X, et al. Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure-Activity Relationship Analysis. J Chem Inf Model. 2017;57:669-679 pubmed publisher
    ..potent compounds with new scaffolds, which led to the discovery of 2-((5-benzyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-N-(naphthalen-1-yl)acetamide (SR86)...
  67. Leese E, Clench M, Morton J, Gardiner P, Carolan V. The Investigation of Unexpected Arsenic Compounds Observed in Routine Biological Monitoring Urinary Speciation Analysis. Toxics. 2017;5: pubmed publisher
    ..arsenocholine, AC; trimethyl arsine oxide, TMAO; dimethylarsenoacetate, DMAA; dimethylarsenoethanol, DMAE; thio-dimethylarsinate, thio-DMA; thio-dimethylarsenoacetate, thio-DMAA and thio-dimethylarsenoethanol, thio-DMAE...
  68. Smith T, Blume L, Straiker A, Cox J, David B, McVoy J, et al. Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation. Mol Pharmacol. 2015;87:747-65 pubmed publisher
    ..CB1Rs, decreased CB1R-mediated G-protein activation (measured by agonist-stimulated [(35)S]GTPγS (guanylyl-5'-[O-thio]-triphosphate) binding) in both cell lines and attenuated inverse agonism by rimonabant in CB1-HEK cells...
  69. Czubatka Bieńkowska A, Macieja A, Sarnik J, Witczak Z, Poplawski T. The oxidative induction of DNA lesions in cancer cells by 5-thio-d-glucose and 6-thio-d-fructopyranose and their genotoxic effects. Part 3. Bioorg Med Chem Lett. 2017;27:1210-1214 pubmed publisher
    b>Thio-sugars have been described as potent inhibitors of cancer cell growth but the detailed mechanism of action remains unknown. Herein we investigated the mechanism of their anticancer action in the HeLa cell line...
  70. Jotani M, Yeo C, Tiekink E. A new monoclinic polymorph of N-(3-methyl-phen-yl)eth-oxy-carbo-thio-amide: crystal structure and Hirshfeld surface analysis. Acta Crystallogr E Crystallogr Commun. 2017;73:1889-1897 pubmed publisher
    ..The thione-S and thio-amide-N-H atoms are syn in each mol-ecule and this facilitates the formation of an eight-membered thio-amide ..
  71. Sivakumaran S, Cardarelli R, Maguire J, Kelley M, Silayeva L, Morrow D, et al. Selective inhibition of KCC2 leads to hyperexcitability and epileptiform discharges in hippocampal slices and in vivo. J Neurosci. 2015;35:8291-6 pubmed publisher
    ..we used the selective KCC2 inhibitor VU0463271 [N-cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]acetamide] to investigate the influence of KCC2 function...
  72. Shen S, Yang X, Shi Y. Application of quantitative NMR for purity determination of standard ACE inhibitors. J Pharm Biomed Anal. 2015;114:190-9 pubmed publisher
    ..products were isolated by HPLC and structurally elucidated by NMR as two pairs of new diastereoisomers, 1-[(2S,4R)-thio-2-methylpropionyl-5-d-ethanedicarboxylicacid]-L-proline and 1-[(2S,4S)-thio-2-methylpropionyl-5-d-..
  73. Stoveken H, Bahr L, Anders M, Wojtovich A, Smrcka A, Tall G. Dihydromunduletone Is a Small-Molecule Selective Adhesion G Protein-Coupled Receptor Antagonist. Mol Pharmacol. 2016;90:214-24 pubmed publisher
    ..DHM), a rotenoid derivative, was validated using cell-free aGPCR/heterotrimeric G protein guanosine 5'-3-O-(thio)triphosphate binding reconstitution assays...
  74. Bläsing M, Amelung W, Schwark L, Lehndorff E. Inland navigation: PAH inventories in soil and vegetation after EU fuel regulation 2009/30/EC. Sci Total Environ. 2017;584-585:19-28 pubmed publisher
    ..We analyzed parent-, alkylated- and thio-PAHs in soil and vine leaves, at two waterways (Rhine and Moselle, Germany), as well as in one ship-free reference ..
  75. Odagaki Y, Kinoshita M, Ota T, Javier Meana J, Callado L, García Sevilla J. Functional activation of Gαq coupled to 5-HT2A receptor and M1 muscarinic acetylcholine receptor in postmortem human cortical membranes. J Neural Transm (Vienna). 2017;124:1123-1133 pubmed publisher
    ..In this study, guanosine-5'-O-(3-[35S]thio)triphosphate ([35S]GTPγS) binding/immunoprecipitation assay for Gαq was applied to ..
  76. Prakasha Gowda A, Spratt T. Active Site Interactions Impact Phosphoryl Transfer during Replication of Damaged and Undamaged DNA by Escherichia coli DNA Polymerase I. Chem Res Toxicol. 2017;30:2033-2043 pubmed publisher
    ..Using thio-substituted dNTPs and differential quench techniques, we determined that when the Arg-fork was disrupted, the rate-..
  77. Nguyen Ngoc L, Vu Quoc T, Duong Quoc H, Vu Quoc M, Truong Minh L, Thang Pham C, et al. Green synthesis and crystal structure of 3-(benzo-thia-zol-2-yl)thio-phene. Acta Crystallogr E Crystallogr Commun. 2017;73:1647-1651 pubmed publisher
    ..4884?(10) and 0.5116?(10), respectively. The thio-phene and benzo-thia-zole rings are almost planar and make dihedral angles of 10.02?(18) and 12...
  78. Dhanalakshmi G, Saravanan V, Mohanakrishnan A, Aravindhan S. Crystal structures of 1-benzene-sulfon-yl-2-methyl-3-(4-nitro-benzoyl)-2,3-di-hydro-1H-indole and 1-benzene-sulfon-yl-2-methyl-3-[(thio-phen-2-yl)carbon-yl]-2,3-di-hydro-1H-indole. Acta Crystallogr E Crystallogr Commun. 2017;73:1555-1559 pubmed publisher
    ..Compound (II) was refined as an inversion twin...
  79. Chang Y, Levason W, Reid G. Developments in the chemistry of the hard early metals (Groups 1-6) with thioether, selenoether and telluroether ligands. Dalton Trans. 2016;45:18393-18416 pubmed
    The coordination chemistry of neutral thio-, seleno- and telluroether ligands towards the hard s-block, f-block and higher oxidation state early d-block metals has developed significantly over the last 15 or so years...
  80. Min C, Seidel D. Asymmetric Brønsted acid catalysis with chiral carboxylic acids. Chem Soc Rev. 2017;46:5889-5902 pubmed publisher
    ..Weakly acidic species such as diols and (thio)ureas, typically classified as hydrogen bonding catalysts, as well as stronger phosphoric acids, have proven to be ..
  81. Braunstein H, Langevin S, Khim M, Adamson J, Hovenkotter K, Kotlarz L, et al. Modular access to vicinally functionalized allylic (thio)morpholinonates and piperidinonates by substrate-controlled annulation of 1,3-azadienes with hexacyclic anhydrides. Org Biomol Chem. 2016;14:8864-8872 pubmed
    ..A modular substrate-controlled hexannulation of inherently promiscuous 1,3-azadienes with hexacyclic anhydrides, which affords versatile vicinally functionalized allylic lactams, in high yields, regio- and stereoselectivities is described. ..
  82. Thorsheim K, Willen D, Tykesson E, Ståhle J, Praly J, Vidal S, et al. Naphthyl thio- and carba-xylopyranosides for exploration of the active site of ?-1,4-galactosyltransferase 7 (?4GalT7). Chemistry. 2017;: pubmed publisher
    ..Favorable ?-? interactions between the 2-naphthyl moiety and a tyrosine side chain were observed for the thio analogs, which open up for design of efficient GAG primers and inhibitors.
  83. Bout A, Teunissen Y, Hashimoto T, Benne R, Tager J. Nucleotide sequence of human peroxisomal 3-oxoacyl-CoA thiolase. Nucleic Acids Res. 1988;16:10369 pubmed
  84. Fu D, Song J, Hou Y, Zhao R, Li J, Mao R, et al. Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers. Eur J Med Chem. 2017;138:1076-1088 pubmed publisher
    ..Among these chemical derivatives, 3-(((1-(4-fluorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)thio)-5,6-diphenyl-1,2,4-triazine (11E) showed the more potent inhibitory effect against three cell lines than 5-Fu...
  85. Shen H, Du G, Liu K, Ye L, Xie S, Jiang L. Synthesis and evaluation of pseudopeptide chiral stationary phases for enantioselective resolution. J Chromatogr A. 2017;1521:53-62 pubmed publisher
    ..polymers were subsequently immobilized onto mercaptopropylated silica bead matrices by means of thio-click chemistry and their potential as the chiral stationary phase (CSP) for high-performance liquid chromatography ..
  86. Teixeira F, Marcos P, Ascenso J, Brancatelli G, Hickey N, Geremia S. Selective Binding of Spherical and Linear Anions by Tetraphenyl(thio)urea-Based Dihomooxacalix[4]arene Receptors. J Org Chem. 2017;82:11383-11390 pubmed publisher
    Three novel tetra(thio)ureido dihomooxacalix[4]arene anion receptors (phenylurea 4a, phenylthiourea 4b, and tert-butylurea 4c) were synthesized and obtained in the cone conformation in solution, as shown by NMR studies...
  87. Bege M, Bereczki I, Herczeg M, Kicsák M, Eszenyi D, Herczegh P, et al. A low-temperature, photoinduced thiol-ene click reaction: a mild and efficient method for the synthesis of sugar-modified nucleosides. Org Biomol Chem. 2017;15:9226-9233 pubmed publisher
    ..coupling was applied for the first time on nucleoside enofuranoside derivatives to produce a broad range of thio-substituted d-ribo, -arabino, -xylo and l-lyxo configured pyrimidine nucleosides...
  88. Kinoshita A, Higashino M, Yoshida K, Aratani Y, Kakuuchi A, Hanada K, et al. Synthesis and evaluation of a potent, well-balanced EP2/EP3 dual agonist. Bioorg Med Chem. 2018;26:200-214 pubmed publisher
    ..As the result, 2-[(2-{(1R,2R)-2-[(1E,4S)-5-cyclopentyl-4-hydroxy-4-methyl-1-penten-1-yl]-5-oxocyclopentyl}eth-yl)thio]-1,3-thiazole-4-carboxylic acid (10) showed excellent potency (human EC50 EP2?=?1...
  89. Amatori S, Ambrosi G, Errico Provenzano A, Fanelli M, Formica M, Fusi V, et al. PdII and PtII complexes with a thio-aza macrocycle ligand containing an intercalating fragment: Structural and antitumor activity studies. J Inorg Biochem. 2016;162:154-161 pubmed publisher
    ..They were obtained using the thio-aza macrocycle 9,18-dimethyl-12,17dithia-9,18,27,28-tetraaaza-29-oxatetracyclo[,7...
  90. Liu M, Wang J, Liu P. HPLC method development, validation, and impurity characterization of a potent antitumor nucleoside, T-dCyd (NSC 764276). J Pharm Biomed Anal. 2016;131:429-435 pubmed publisher
    An HPLC method for the assay of an anticancer nucleoside, 4'-thio-2'-deoxycytidine (T-dCyd, NSC 764276), has been developed and validated...
  91. Pascoe D, Ling K, Cockroft S. The Origin of Chalcogen-Bonding Interactions. J Am Chem Soc. 2017;139:15160-15167 pubmed publisher
    ..the chalcogen-bonding interactions being dominated by n ? ?* orbital delocalization between a lone pair (n) of a (thio)amide donor and the antibonding ?* orbital of an acceptor thiophene or selenophene...
  92. Muller S, Ebert F, Raber G, Meyer S, Bornhorst J, Hüwel S, et al. Effects of arsenolipids on in vitro blood-brain barrier model. Arch Toxicol. 2018;92:823-832 pubmed publisher
    ..AsHC 360, AsHC 444, and two arsenic-containing fatty acids, AsFA 362 and AsFA 388) as well as of their metabolites (thio/oxo-dimethylpropionic acid, dimethylarsinic acid) on porcine brain capillary endothelial cells (PBCECs, in vitro ..