ABTB1

Summary

Gene Symbol: ABTB1
Description: ankyrin repeat and BTB domain containing 1
Alias: BPOZ, BTB3, BTBD21, EF1ABP, PP2259, ankyrin repeat and BTB/POZ domain-containing protein 1, ankyrin repeat and BTB (POZ) domain containing 1, elongation factor 1A-binding protein
Species: human
Products:     ABTB1

Top Publications

  1. Sapianik A, Kiskin M, Kovalenko K, Samsonenko D, Dybtsev D, Audebrand N, et al. Rational synthesis and dimensionality tuning of MOFs from preorganized heterometallic molecular complexes. Dalton Trans. 2019;: pubmed publisher
    ..results in 3D srs topology frameworks with intersecting systems or isolated channels, and 1,3,5-benzenetribenzoate (btb3-) results in layered hcb isostructural compounds additionally stabilized with H-π interactions between the layers...
  2. Roy A, Rangasamy S, Kundu M, Pahan K. BPOZ-2 Gene Delivery Ameliorates Alpha-Synucleinopathy in A53T Transgenic Mouse Model of Parkinson's Disease. Sci Rep. 2016;6:22067 pubmed publisher
    Ankyrin-rich BTB/POZ domain containing protein-2 or BPOZ-2, a scaffold protein, has been recently shown to control the degradation of many biological proteins ranging from embryonic development to tumor progression...
  3. Dai K, Wei W, Liew C. Molecular cloning and characterization of a novel human gene containing ankyrin repeat and double BTB/POZ domain. Biochem Biophys Res Commun. 2000;273:991-6 pubmed
    A novel human gene containing an ankyrin repeat and BTB/POZ domains (BPOZ) was isolated from a human leukocyte cDNA library...
  4. Maezawa S, Hayano T, Koiwai K, Fukushima R, Kouda K, Kubota T, et al. Bood POZ containing gene type 2 is a human counterpart of yeast Btb3p and promotes the degradation of terminal deoxynucleotidyltransferase. Genes Cells. 2008;13:439-57 pubmed publisher
    Bood POZ containing gene type 2 (BPOZ-2) is involved in the growth suppressive effect of the phosphatase and tensin homologue (PTEN)...
  5. Hayano T, Koiwai K, Ishii H, Maezawa S, Kouda K, Motoyama T, et al. TdT interacting factor 1 enhances TdT ubiquitylation through recruitment of BPOZ-2 into nucleus from cytoplasm. Genes Cells. 2009;14:1415-27 pubmed publisher
    We isolated human cDNA clone encoding Bood POZ containing gene type 2 (BPOZ-2) as a gene with a product that binds to TdT interacting factor 1 (TdIF1) using a yeast two-hybrid system...
  6. Kitamura H, Ozono E, Iwanaga R, Bradford A, Okuno J, Shimizu E, et al. Identification of novel target genes specifically activated by deregulated E2F in human normal fibroblasts. Genes Cells. 2015;20:739-57 pubmed publisher
    ..The analysis identified nine novel targets (BIM, RASSF1, PPP1R13B, JMY, MOAP1, RBM38, ABTB1, RBBP4 and RBBP7), many of which are involved in the p53 and RB tumor suppressor pathways...
  7. Unoki M, Nakamura Y. Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Oncogene. 2001;20:4457-65 pubmed
    ..Among them, we report here the further analyses of eight genes, EGR2/Krox-20, BPOZ, APS, HCLS1/HS1, DUSP1/MKP1, NDRG1/Drg1/RTP, NFIL3/E4BP4, and a novel gene (PINK1, PTEN-induced putative kinase)...
  8. Koiwai K, Maezawa S, Hayano T, Iitsuka M, Koiwai O. BPOZ-2 directly binds to eEF1A1 to promote eEF1A1 ubiquitylation and degradation and prevent translation. Genes Cells. 2008;13:593-607 pubmed publisher
    Bood POZ containing gene type 2 (BPOZ-2), which contains ankyrin repeats, NLS, BTB/POZ domains and LXXLL motifs, is an adaptor protein for the E3 ubiquitin ligase scaffold protein CUL3...
  9. Wan Q, Tang J, Han Y, Wang D. Co-expression modules construction by WGCNA and identify potential prognostic markers of uveal melanoma. Exp Eye Res. 2018;166:13-20 pubmed publisher
    ..The hub gene SLC17A7, NTRK2, ABTB1 and ADPRHL1 might play a vital role in recurrence of uveal melanoma...