ABO

Summary

Gene Symbol: ABO
Description: ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase
Alias: A3GALNT, A3GALT1, GTB, NAGAT, histo-blood group ABO system transferase, ABO blood group (transferase A, alpha 1-3-N-acetylgalactosaminyltransferase; transferase B, alpha 1-3-galactosyltransferase), B(A) alpha-1,3-galactosyltransferase, histo-blood group A2 transferase
Species: human
Products:     ABO

Top Publications

  1. Yamamoto F, Marken J, Tsuji T, White T, Clausen H, Hakomori S. Cloning and characterization of DNA complementary to human UDP-GalNAc: Fuc alpha 1----2Gal alpha 1----3GalNAc transferase (histo-blood group A transferase) mRNA. J Biol Chem. 1990;265:1146-51 pubmed
    ..No restriction fragment length polymorphism was found to correlate with ABO blood group type...
  2. Kiechl S, Pare G, Barbalic M, Qi L, Dupuis J, Dehghan A, et al. Association of variation at the ABO locus with circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin: a meta-analysis. Circ Cardiovasc Genet. 2011;4:681-6 pubmed publisher
    ..adhesion molecule-1, soluble P-selectin, and soluble E-selectin have been associated with variation at the ABO locus...
  3. Reilly M, Li M, He J, Ferguson J, Stylianou I, Mehta N, et al. Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies. Lancet. 2011;377:383-92 pubmed publisher
    ..versus those with angiographic CAD but no myocardial infarction, we identified a novel association at the ABO locus (p=7·62×10(-9))...
  4. Amundadottir L, Kraft P, Stolzenberg Solomon R, Fuchs C, Petersen G, Arslan A, et al. Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer. Nat Genet. 2009;41:986-90 pubmed publisher
    ..20; 95% confidence interval 1.12-1.28). This SNP maps to the first intron of the ABO blood group gene...
  5. Fry A, Griffiths M, Auburn S, Diakite M, Forton J, Green A, et al. Common variation in the ABO glycosyltransferase is associated with susceptibility to severe Plasmodium falciparum malaria. Hum Mol Genet. 2008;17:567-76 pubmed
    There is growing epidemiological and molecular evidence that ABO blood group affects host susceptibility to severe Plasmodium falciparum infection...
  6. Migot Nabias F, Pelleau S, Watier L, Guitard J, Toly C, De Araujo C, et al. Red blood cell polymorphisms in relation to Plasmodium falciparum asymptomatic parasite densities and morbidity in Senegal. Microbes Infect. 2006;8:2352-8 pubmed
    ..The pressure exerted in the area by other non-malarial infectious diseases as well as the genetic heterogeneity of circulating parasites may also contribute to these observations. ..
  7. Olsson M, Irshaid N, Hosseini Maaf B, Hellberg A, Moulds M, Sareneva H, et al. Genomic analysis of clinical samples with serologic ABO blood grouping discrepancies: identification of 15 novel A and B subgroup alleles. Blood. 2001;98:1585-93 pubmed
    Since the cloning in 1990 of complementary DNA corresponding to messenger RNA transcribed at the blood group ABO locus, polymorphisms and phenotype-genotype correlations have been reported by several investigators...
  8. Kominato Y, Tsuchiya T, Hata N, Takizawa H, Yamamoto F. Transcription of human ABO histo-blood group genes is dependent upon binding of transcription factor CBF/NF-Y to minisatellite sequence. J Biol Chem. 1997;272:25890-8 pubmed
    We have studied the transcriptional regulatory mechanism of the human histo-blood group ABO genes, and identified DNA cis-elements and trans-activating protein that control the expression of these genes which are important in blood ..
  9. Olsson M, Chester M. Frequent occurrence of a variant O1 gene at the blood group ABO locus. Vox Sang. 1996;70:26-30 pubmed
    Blood group ABO polymorphism was analysed in genomic DNA isolated from 150 blood donors by restriction endonuclease digestion of three polymerase chain reaction-amplified exons in the ABO genes and by sequencing of randomly selected ..

More Information

Publications85

  1. Yamamoto F, Clausen H, White T, Marken J, Hakomori S. Molecular genetic basis of the histo-blood group ABO system. Nature. 1990;345:229-33 pubmed
    The histo-blood group ABO, the major human alloantigen system, involves three carbohydrate antigens (ABH)...
  2. Olsson M, Guerreiro J, Zago M, Chester M. Molecular analysis of the O alleles at the blood group ABO locus in populations of different ethnic origin reveals novel crossing-over events and point mutations. Biochem Biophys Res Commun. 1997;234:779-82 pubmed
    The blood group ABO genotypes of 138 group O individuals with three different ethnic origins in Brazil were determined, including Whites, Blacks and Amerindians...
  3. Williams F, Carter A, Hysi P, Surdulescu G, Hodgkiss D, Soranzo N, et al. Ischemic stroke is associated with the ABO locus: the EuroCLOT study. Ann Neurol. 2013;73:16-31 pubmed publisher
    ..6 × 10(-186)), rs10665 with FVII (p = 2.4 × 10(-47)), and rs505922 in the ABO gene with both von Willebrand factor (p = 4.7 × 10(-57)) and factor VIII (p = 1.2 × 10(-36))...
  4. Tanikawa C, Urabe Y, Matsuo K, Kubo M, Takahashi A, Ito H, et al. A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population. Nat Genet. 2012;44:430-4, S1-2 pubmed publisher
    ..we identified two susceptibility loci at the PSCA gene (encoding prostate stem cell antigen) at 8q24 and at the ABO blood group locus at 9q34...
  5. Yamamoto F, McNeill P, Hakomori S. Human histo-blood group A2 transferase coded by A2 allele, one of the A subtypes, is characterized by a single base deletion in the coding sequence, which results in an additional domain at the carboxyl terminal. Biochem Biophys Res Commun. 1992;187:366-74 pubmed
    ..identified a possible mutation which characterizes A2 alleles (a minor subtype of A) at the human histo-blood group ABO locus based on polymerase chain reaction (PCR) of genomic DNA, followed by nucleotide sequencing of the amplified ..
  6. Nakao M, Matsuo K, Hosono S, Ogata S, Ito H, Watanabe M, et al. ABO blood group alleles and the risk of pancreatic cancer in a Japanese population. Cancer Sci. 2011;102:1076-80 pubmed publisher
    Several studies have investigated a possible association between the ABO blood group and the risk of pancreatic cancer (PC), but this association has not been fully evaluated in Asian populations...
  7. Paterson A, Lopes Virella M, Waggott D, Boright A, Hosseini S, Carter R, et al. Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin. Arterioscler Thromb Vasc Biol. 2009;29:1958-67 pubmed publisher
    ..E-selectin levels have been associated with the ABO blood group phenotype...
  8. Tregouet D, Heath S, Saut N, Biron Andreani C, Schved J, Pernod G, et al. Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach. Blood. 2009;113:5298-303 pubmed publisher
    ..Only 3 SNPs located in the FV and ABO blood group genes were found associated with VTE at a genome-wide significant level of 1.7 x 10(-7)...
  9. Yuan X, Waterworth D, Perry J, Lim N, Song K, Chambers J, et al. Population-based genome-wide association studies reveal six loci influencing plasma levels of liver enzymes. Am J Hum Genet. 2008;83:520-8 pubmed publisher
    ..In addition, we confirmed the associations between the GGT1 locus and GGT levels and between the ABO locus and ALP levels...
  10. Yamamoto F, McNeill P, Hakomori S. Genomic organization of human histo-blood group ABO genes. Glycobiology. 1995;5:51-8 pubmed
    We have isolated human genomic DNA clones encompassing 30 kbp of the histo-blood group ABO locus. The locations of the exons have been mapped and the nucleotide sequences of the exon-intron boundaries have been determined...
  11. Jenkins P, O Donnell J. ABO blood group determines plasma von Willebrand factor levels: a biologic function after all?. Transfusion. 2006;46:1836-44 pubmed
    For many years, an association between ABO histo-blood group and risk of thrombosis has been recognized...
  12. Chu X, Pan C, Zhao S, Liang J, Gao G, Zhang X, et al. A genome-wide association study identifies two new risk loci for Graves' disease. Nat Genet. 2011;43:897-901 pubmed publisher
    ..Moreover, we identified strong associations of TSHR and major histocompatibility complex class II variants with persistently TRAb-positive Graves' disease...
  13. He M, Wu C, Xu J, Guo H, Yang H, Zhang X, et al. A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and ? fetoprotein and their associations with cancer risk. Gut. 2014;63:143-51 pubmed publisher
    ..3, FUT2-CA11 at 19q13.3 and B3GNT3 at 19p13.1; p=1.16×10(-13)-3.30×10(-290)); four for CEA (ABO at 9q34.2, FUT6 at 19p13.3, FUT2 at 19q13.3 and FAM3B at 21q22.3; p=3.33×10(-22)-5...
  14. Smith N, Chen M, Dehghan A, Strachan D, Basu S, Soranzo N, et al. Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium. Circulation. 2010;121:1382-92 pubmed publisher
    ..3x10(-10)), and 19p13.2 (1.3x10(-9)). All loci were within genes, including 6 new candidate genes, as well as ABO (9q34) and VWF (12p13). For FVIII, 5 loci were identified and overlapped vWF findings...
  15. Wolpin B, Kraft P, Gross M, Helzlsouer K, Bueno de Mesquita H, Steplowski E, et al. Pancreatic cancer risk and ABO blood group alleles: results from the pancreatic cancer cohort consortium. Cancer Res. 2010;70:1015-23 pubmed publisher
    A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown...
  16. Yamamoto F, McNeill P, Yamamoto M, Hakomori S, Harris T. Molecular genetic analysis of the ABO blood group system: 3. A(X) and B(A) alleles. Vox Sang. 1993;64:171-4 pubmed
    ..to determine the nucleotide sequences of the coding region in the last two coding exons of the histo-blood group ABO genes from one A(X) and one B(A) individual...
  17. Ogasawara K, Bannai M, Saitou N, Yabe R, Nakata K, Takenaka M, et al. Extensive polymorphism of ABO blood group gene: three major lineages of the alleles for the common ABO phenotypes. Hum Genet. 1996;97:777-83 pubmed
    Polymorphism of the ABO blood group gene was investigated in 262 healthy Japanese donors by a polymerase chain reactions-single-strand conformation polymorphism (PCR-SSCP) method, and 13 different alleles were identified...
  18. Ogasawara K, Yabe R, Uchikawa M, Nakata K, Watanabe J, Takahashi Y, et al. Recombination and gene conversion-like events may contribute to ABO gene diversity causing various phenotypes. Immunogenetics. 2001;53:190-9 pubmed
    We identified five different alleles, tentatively named ABO*O301, *0302, *R102, *R103, and *A110, in Japanese individuals possessing the blood group O phenotype...
  19. Ogasawara K, Yabe R, Uchikawa M, Saitou N, Bannai M, Nakata K, et al. Molecular genetic analysis of variant phenotypes of the ABO blood group system. Blood. 1996;88:2732-7 pubmed
    b>ABO is clinically the most important blood group system in transfusion medicine and includes many variant phenotypes...
  20. Olsson M, Chester M. Heterogeneity of the blood group Ax allele: genetic recombination of common alleles can result in the Ax phenotype. Transfus Med. 1998;8:231-8 pubmed
    The Ax phenotype is an important subgroup of the ABO blood group system. Its inheritance does not always follow Mendelian rules and recent studies suggested that different alleles can result in this phenotype...
  21. Hata Y, Kominato Y, Yamamoto F, Takizawa H. Characterization of the human ABO gene promoter in erythroid cell lineage. Vox Sang. 2002;82:39-46 pubmed
    The human ABO blood group system is important in transfusion and organ transplantation. Although the molecular basis of the ABO gene has been established, recent studies have begun to characterize the mechanism of the ABO gene expression...
  22. Qi L, Cornelis M, Kraft P, Jensen M, van Dam R, Sun Q, et al. Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes. Hum Mol Genet. 2010;19:1856-62 pubmed publisher
    ..the Nurses' Health Study, and identified genome-wide significant associations between a cluster of markers at the ABO locus (9q34) and plasma sE-selectin concentration...
  23. Barbalic M, Dupuis J, Dehghan A, Bis J, Hoogeveen R, Schnabel R, et al. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. Hum Mol Genet. 2010;19:1863-72 pubmed publisher
    ..53 x 10(-23)). Both sP-selectin and sICAM-1 were associated with ABO gene variants (rs579459, P = 1.86 x 10(-41) and rs649129, P = 1...
  24. Kominato Y, Hata Y, Takizawa H, Matsumoto K, Yasui K, Tsukada J, et al. Alternative promoter identified between a hypermethylated upstream region of repetitive elements and a CpG island in human ABO histo-blood group genes. J Biol Chem. 2002;277:37936-48 pubmed
    We have studied the expression of human histo-blood group ABO genes during erythroid differentiation, using an ex vivo culture of AC133(-)CD34(+) cells obtained from peripheral blood...
  25. Yamamoto F, Hakomori S. Sugar-nucleotide donor specificity of histo-blood group A and B transferases is based on amino acid substitutions. J Biol Chem. 1990;265:19257-62 pubmed
    ..The second substitution (glycine in A and serine in B) also affects the specificity. We have also created new enzymes which catalyze the transfer of both GalNAc and Gal, and may provide an explanation of the rare cis-AB phenotype. ..
  26. Pare G, Chasman D, Kellogg M, Zee R, Rifai N, Badola S, et al. Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women. PLoS Genet. 2008;4:e1000118 pubmed publisher
    ..We also find that a single SNP (rs507666, P = 5.1x10(-29)) at the ABO (9q34.2) locus is highly correlated with sICAM-1 concentrations...
  27. Patenaude S, Seto N, Borisova S, Szpacenko A, Marcus S, Palcic M, et al. The structural basis for specificity in human ABO(H) blood group biosynthesis. Nat Struct Biol. 2002;9:685-90 pubmed
    The human ABO(H) blood group antigens are produced by specific glycosyltransferase enzymes...
  28. Carpeggiani C, Coceani M, Landi P, Michelassi C, L Abbate A. ABO blood group alleles: A risk factor for coronary artery disease. An angiographic study. Atherosclerosis. 2010;211:461-6 pubmed publisher
    To analyze the impact of ABO groups on coronary heart disease risk factors, coronary involvement and prognosis...
  29. Samad N, Yong P, Mahendran K. Routine diabetes screening in blood donation campaigns. Malays J Pathol. 2015;37:137-40 pubmed
    ..screening was done by checking random capillary blood sugar (RCBS) levels while performing a Hemoglobin test and ABO grouping. Donors with RCBS of ≥ 7...
  30. Siatkowski R. Excellence in Ophthalmology: Continuous Certification. Ophthalmology. 2016;123:S25-9 pubmed publisher
    Over the course of a century, American medical specialty boards including the American Board of Ophthalmology (ABO) have developed significant expertise in assessing physician competence on completion of postgraduate training and, more ..
  31. Weerakkody R, Lokuliyana P, Sheriff M. Acute renal failure during immediate post transplant period due to a pericardial effusion. BMC Res Notes. 2015;8:587 pubmed publisher
    ..He was hemodialysed adequately for 6 months, while being worked up for transplantation. He received an ABO matched, living donor transplant...
  32. Takahashi Y, Isa K, Sano R, Nakajima T, Kubo R, Takahashi K, et al. Presence of nucleotide substitutions in transcriptional regulatory elements such as the erythroid cell-specific enhancer-like element and the ABO promoter in individuals with phenotypes A3 and B3, respectively. Vox Sang. 2014;107:171-80 pubmed publisher
    ..8-kb site, has been identified in the first intron of the human ABO blood group gene...
  33. Takeuchi M, Mizuki N, Meguro A, Ombrello M, Kirino Y, Satorius C, et al. Dense genotyping of immune-related loci implicates host responses to microbial exposure in Behçet's disease susceptibility. Nat Genet. 2017;49:438-443 pubmed publisher
    ..b>ABO non-secretor genotypes for two ancestry-specific FUT2 SNPs showed strong disease association (P = 5...
  34. Villafuerte Castrejón M, Moran E, Reyes Montero A, Vivar Ocampo R, Peña Jiménez J, Rea López S, et al. Towards Lead-Free Piezoceramics: Facing a Synthesis Challenge. Materials (Basel). 2016;9: pubmed publisher
    ..In this work, several methods to obtain ferro-pyro-piezoelectric families of materials featuring the well-known ABO? perovskite structure (or related) such as BaTiO?, Ba1-xCaxTi1-y
  35. Oh D, Kang E, Yu S, Chun K, Huh W, Jang H, et al. Case Report of Kidney Paired Donation (KPD) with Desensitization: the Strategy and Experience of 3-Way KPD in Samsung Medical Center. J Korean Med Sci. 2018;33:e39 pubmed publisher
    ..Positive cross match and ABO incompatible transplantation has been successfully accomplished in selective cases with several pre-conditionings...
  36. Hua Z, Li L, Li Z. [Serological characteristic and molecular basis of A2 subgroup in Shanghai population]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2014;31:659-62 pubmed publisher
    ..The A and AB phenotypes were screened with anti-A1. Exons 1 to 7 and intron 6 of the ABO gene were analyzed with polymerase chain reaction-sequence-based typing (PCR-SBT) method...
  37. Chen K, Ma H, Li L, Zang R, Wang C, Song F, et al. Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women. Nat Commun. 2014;5:4682 pubmed publisher
    ..2 (rs11175194 in SRGAP1, P(meta) = 1.14 × 10(-7)) and 9q34.2 (rs633862 near ABO and SURF6, P(meta) = 8.57 × 10(-7)) (P<0.05 in all three stages)...
  38. Palleschi A, Mendogni P, Tosi D, Montoli M, Carrinola R, Mariolo A, et al. Lung Transplantation From Donors After Previous Cardiac Surgery: Ideal Graft in Marginal Donor?. Transplant Proc. 2017;49:686-691 pubmed publisher
    ..The others' eligibility criteria for organ allocation, such as ABO compatibility, PaO2/FiO2 ratio, absence of aspiration, or sepsis were respected...
  39. Demirel G, Akar M, Celik I, Erdeve O, Uras N, Oguz S, et al. Single versus multiple dose intravenous immunoglobulin in combination with LED phototherapy in the treatment of ABO hemolytic disease in neonates. Int J Hematol. 2011;93:700-703 pubmed publisher
    ..of IVIG in combination with light emitting diode (LED) phototherapy in patients with neonatal jaundice secondary to ABO blood incompatibility, and compared the efficacy of these treatments with that in a group of patients who received ..
  40. Nydegger U, Wuillemin W, Julmy F, Meyer B, Carrel T. Association of ABO histo-blood group B allele with myocardial infarction. Eur J Immunogenet. 2003;30:201-6 pubmed
    To investigate a possible association of ABO blood group alleles with myocardial infarction, a case-control study comprising 177 patients (median age 57.0 years; range 32-72 years) and 89 controls was performed...
  41. Blumberg N, Cholette J, Schmidt A, Phipps R, Spinelli S, Heal J, et al. Management of Platelet Disorders and Platelet Transfusions in ICU Patients. Transfus Med Rev. 2017;31:252-257 pubmed publisher
    ..methods of improving the safety and efficacy of platelet transfusions include use of alternate strategies such as antifibrinolytics; use of ABO-identical, leukoreduced, and washed platelet transfusions; and improved storage solutions.
  42. Yu Q, Deng Z, Wu G, Lian Y, Su Y. Molecular genetic analysis for a novel Ael allele of the ABO blood group system. J Hum Genet. 2005;50:671-3 pubmed
    The ABO blood group is the most important system in clinical transfusion medicine...
  43. Drukker L, Srebnik N, Elstein D, Levitt L, Samueloff A, Farkash R, et al. The association between ABO blood group and obstetric hemorrhage. J Thromb Thrombolysis. 2016;42:340-5 pubmed publisher
    Whether intra- and early post-partum hemorrhage is influenced by ABO blood groups remains unknown. Therefore, we compared women with O to non-O blood groups with regard to maternal post-partum hemorrhage and transfusion need...
  44. Mottram L, Wiklund G, Larson G, Qadri F, Svennerholm A. FUT2 non-secretor status is associated with altered susceptibility to symptomatic enterotoxigenic Escherichia coli infection in Bangladeshis. Sci Rep. 2017;7:10649 pubmed publisher
    Polymorphisms of the FUT2 gene alters glycan ABO(H) blood group and Lewis antigen expression (commonly known as non-secretor status) in the small intestinal mucosa...
  45. Thuresson B, Chester M, Storry J, Olsson M. ABO transcript levels in peripheral blood and erythropoietic culture show different allele-related patterns independent of the CBF/NF-Y enhancer motif and multiple novel allele-specific variations in the 5'- and 3'-noncoding regions. Transfusion. 2008;48:493-504 pubmed
    Mechanisms regulating the ABO gene are unclear, especially in the hematopoietic compartment. The number of 43-bp repeats in the CBF/NF-Y-binding enhancer region is considered to have a major influence on transcription...
  46. Ozcan M, Sevinç S, Erkan V, Yurdugül Y, Sarici S. Hyperbilirubinemia due to minor blood group (anti-E) incompatibility in a newborn: a case report. Turk Pediatri Ars. 2017;52:162-164 pubmed publisher
    In addition to Rh and ABO incompatibilities subgroup incompatibilities may rarely play a role among the causes of hemolytic anemia and indirect hyperbilirubinemia in newborns...
  47. Yu M, Wang C, Chen T, Hu S, Yi K, Tan X. ABO blood groups and risk of deep venous thromboembolism in Chinese Han population from Chaoshan region in South China. Saudi Med J. 2017;38:396-399 pubmed publisher
    Objectives: To demonstrate the prevalence of ABO blood groups with deep venous thromboembolism in Chinese Han population...
  48. Ho E, Yasutomi M, Gounder D, Dittmer I. ABO blood group incompatible renal transplantation in New Zealand: a report of the first 20 cases. N Z Med J. 2016;129:45-9 pubmed
    To report on the first 20 ABO blood group incompatible (ABOi) renal transplants performed in New Zealand...
  49. Rueedi R, Ledda M, Nicholls A, Salek R, Marques Vidal P, Morya E, et al. Genome-wide association study of metabolic traits reveals novel gene-metabolite-disease links. PLoS Genet. 2014;10:e1004132 pubmed publisher
    ..The replication of previous associations and our new discoveries demonstrate the potential of untargeted metabolomics GWAS to robustly identify molecular disease markers. ..
  50. González Vicent M, Sanz J, Fuster J, Cid J, de Heredia C, Morillo D, et al. Autoimmune hemolytic anemia (AIHA) following allogeneic hematopoietic stem cell transplantation (HSCT): A retrospective analysis and a proposal of treatment on behalf of the Grupo Español De Trasplante de Medula Osea en Niños (GETMON) and the Grupo E. Transfus Med Rev. 2018;: pubmed publisher
    ..025). We analyzed the factors involved in the response to rituximab and found a better response when there was ABO donor/receptor disparity (P=.014) and in those patients with B lymphocytes count above the median (38/μL) (P=...
  51. Tang W, Teichert M, Chasman D, Heit J, Morange P, Li G, et al. A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium. Genet Epidemiol. 2013;37:512-521 pubmed publisher
    ..Meta-analysis of these results identified two known loci, in F5 and ABO. Top 1,047 tag SNPs (P ≤ 0...
  52. Wang F, Zhang Y, Zhang G, Liu Y, Sun L, Liu Y. Association of ABO Blood Types and Clinicopathological Features of Prostate Cancer. Dis Markers. 2017;2017:9237481 pubmed publisher
    To investigate the association between ABO blood types and clinicopathological characteristics in patients with prostate cancer (PC).
  53. Roubinet F, Kermarrec N, Despiau S, Apoil P, Dugoujon J, Blancher A. Molecular polymorphism of O alleles in five populations of different ethnic origins. Immunogenetics. 2001;53:95-104 pubmed
    Sequences of exons 6 and 7 of the O allele of the ABO gene were studied in 317 individuals of the O phenotype from five different ethnic groups (Basques, Berbers, Akans from the Ivory Coast, and Amerindians: Cayapas from Ecuador and ..
  54. Barahona A. Medical Genetics and the First Studies of the Genetics of Populations in Mexico. Genetics. 2016;204:11-9 pubmed publisher
    ..Salazar Mallén's studies on the distribution and characterization of ABO blood groups in indigenous populations were the starting point while Karl's studies on the distribution of abnormal ..
  55. Grey D, Fong E, Cole C, Jensen J, Finlayson J. ABO serology in a case of persistent weak A in a recipient following a group O-matched unrelated bone marrow transplant. Immunohematology. 2017;33:99-104 pubmed
    ..The engraftment process following ABO-incompatible allogeneic HSCT results in the transition from patient blood group to donor blood group in the ..
  56. Novaretti M, Domingues A, Manhani R, Pinto E, Dorlhiac Llacer P, Chamone D. ABO genotyping in leukemia patients reveals new ABO variant alleles. Genet Mol Res. 2008;7:87-94 pubmed
    The ABO blood group is the most important blood group system in transfusion medicine and organ transplantation. To date, more than 160 ABO alleles have been identified by molecular investigation...
  57. Alheim M, Wennberg L, Wikstrom A. Pronase independent flow cytometry crossmatching of rituximab treated patients. Hum Immunol. 2018;79:132-135 pubmed publisher
    b>ABO-incompatible (ABOi) kidney transplantation has become an established strategy to increase the number of available living donors...
  58. Markt S, Shui I, Unger R, Urun Y, Berg C, Black A, et al. ABO blood group alleles and prostate cancer risk: Results from the breast and prostate cancer cohort consortium (BPC3). Prostate. 2015;75:1677-81 pubmed publisher
    b>ABO blood group has been associated with risk of cancers of the pancreas, stomach, ovary, kidney, and skin, but has not been evaluated in relation to risk of aggressive prostate cancer...
  59. Hogan K, Burmester J, Caldwell M, Hogan Q, Coursin D, Green D, et al. Perioperative genomic profiles using structure-specific oligonucleotide probes. Clin Med Res. 2009;7:69-84 pubmed publisher
    ..CYP2C19, CYP2D6, CYP3A4, CYP3A5, beta2AR, TPMT, F2, F5, F7, MTHFR, TNFalpha, TNFbeta, CCR5, ApoE, HBB, MYH7, ABO and Gender (PRKY, PFKFB1)...
  60. Rios D, Fernandes A, Carvalho M, Figueiredo R, Guimarães D, Reis D, et al. Hemodialysis vascular access thrombosis: The role of factor V Leiden, prothrombin gene mutation and ABO blood groups. Clin Chim Acta. 2011;412:425-9 pubmed publisher
    ..between HD vascular access thrombosis and mutations in the prothrombin and factor V Leiden (FV) genes and ABO blood system...
  61. Jiang E, Yu P, Zhang S, Li C, Ding M, Wang B, et al. Establishment of an alternative efficiently genotyping strategy for human ABO gene. Leg Med (Tokyo). 2017;29:72-76 pubmed publisher
    b>ABO genotyping is used in several disciplines, including transfusion, transplantation, human evolution, and forensic medicine. Detection of single nucleotide polymorphisms (SNPs) on a locus is a common way to identify different genotypes...
  62. Liu H, Chen Y, Chen P, Lyou J, Hu H, Ho Y, et al. A Novel Ael allele derived from a unique 816insG in Exon 7 of the ABO gene. J Formos Med Assoc. 2007;106:969-74 pubmed
    The ABO blood group system is the most important blood group system in transfusion medicine. In addition to the major A, B and O alleles, many rare alleles with weak expression of the A or B antigens on RBCs have been defined...
  63. Suástegui Román R, Yescas Gomez P, Guerrero Camacho J, Ochoa Morales A, Granados J, Jara Prado A, et al. [Frequency of apolipoprotein E in a Nahua population]. Rev Invest Clin. 2002;54:415-21 pubmed
    ..We studied a Nahua Indian-population in the State of Morelos (Santo Domingo Ocotitlan). The ABO blood type of all individuals was determined and compared with the findings of other Nahua group from the State of ..
  64. Hong X, Yin Y, Xu X, Ma K, Lan X, Liu Y, et al. [C742T mutation of ?1, 3 N-acetyl-D-galactosaminyltransferase gene is responsible for A2 subgroup]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2011;19:702-5 pubmed
    The objective of this study was to analyze the molecular genetic basis for 2 individuals with A2B phenotype of ABO subtype...
  65. De Oliveira D, Hartley Tassell L, Everest Dass A, Day C, Dabbs R, Ve T, et al. Blood Group Antigen Recognition via the Group A Streptococcal M Protein Mediates Host Colonization. MBio. 2017;8: pubmed publisher
    ..The oral epithelial tract is a niche highly abundant in glycosylated structures, particularly those of the ABO(H) blood group antigen family...
  66. Rizzato C, Campa D, Giese N, Werner J, Rachakonda P, Kumar R, et al. Pancreatic cancer susceptibility loci and their role in survival. PLoS ONE. 2011;6:e27921 pubmed publisher
    ..Single nucleotide polymorphisms (SNPs) in ABO, sonic hedgehog (SHH), telomerase reverse transcriptase (TERT), nuclear receptor subfamily 5, group A, member 2 (..
  67. Timmann C, Thye T, Vens M, Evans J, May J, Ehmen C, et al. Genome-wide association study indicates two novel resistance loci for severe malaria. Nature. 2012;489:443-6 pubmed publisher
    ..Our findings underline the potential of the GWA approach to provide candidates for the development of control measures against infectious diseases in humans. ..
  68. Pruissen D, Rosendaal F, Gorter J, Garcia A, Kappelle L, Algra A. Haemostatic genetic variants, ABO blood group and bleeding risk during oral anticoagulant treatment after cerebral ischaemia of arterial origin. J Neurol. 2007;254:1660-5 pubmed
    ..The Ala312Thr variant in the alpha fibrinogen gene is associated with a decreased and factor V Leiden with an increased bleeding risk in patients on anticoagulant treatment after cerebral ischaemia of presumed arterial origin. ..
  69. Chen Y, Chen J, Lin T, Huang T, Wang S, Lee M, et al. ABO/secretor genetic complex is associated with the susceptibility of childhood asthma in Taiwan. Clin Exp Allergy. 2005;35:926-32 pubmed
    Histo-blood groups, ABO, Lewis (Le) and secretor (Se) were found to be associated with lower lung function and wheezing in coal miners as well as in asthmatic children in some studies but not others, possibly reflecting the genetic ..
  70. Qin F, He J, Zhu F, Liu J, Chen S, Fu Q, et al. [Determination of ABO blood group genotypes with one tube PCR reaction]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2005;13:1117-9 pubmed
    This study was aimed to establish one tube PCR reaction technique to determine ABO blood group genotypes...
  71. Jia X, Li C, Li D, Liu Y. TDDFT study on excited state intramolecular proton transfer mechanism in 2-amino-3-(2'-benzazolyl)-quinolines. Spectrochim Acta A Mol Biomol Spectrosc. 2018;192:168-173 pubmed publisher
    The intramolecular proton transfer reaction of the 2-amino-3-(2'-benzoxazolyl)-quinoline (ABO) and 2-amino-3-(2'-benzothiazolyl)-quinoline (ABT) molecules in both S0 and S1 states at B3LYP/6-311++G(d,p) level in ..
  72. Guo M, Luo G, Lu R, Shi W, Cheng H, Lu Y, et al. Distribution of Lewis and Secretor polymorphisms and corresponding CA19-9 antigen expression in a Chinese population. FEBS Open Bio. 2017;7:1660-1671 pubmed publisher
    The Lewis (FUT3) and Secretor (FUT2) genes, corresponding to secretion of Lewis ABO (H) histo-blood group antigen CA19-9, are highly polymorphic with differences between populations...
  73. Kim Wanner S, Bug G, Steinmann J, Ajib S, Sorg N, Poppe C, et al. Erythrocyte depletion from bone marrow: performance evaluation after 50 clinical-scale depletions with Spectra Optia BMC. J Transl Med. 2017;15:174 pubmed publisher
    Red blood cell (RBC) depletion is a standard graft manipulation technique for ABO-incompatible bone marrow (BM) transplants. The BM processing module for Spectra Optia, "BMC", was previously introduced...
  74. Grimm L, Weissbach S, Flügge F, Begemann N, Palcic M, Peters T. Protein NMR Studies of Substrate Binding to Human Blood Group?A and B Glycosyltransferases. Chembiochem. 2017;18:1260-1269 pubmed publisher
    Donor and acceptor substrate binding to human blood group?A and B glycosyltransferases (GTA, GTB) has been studied by a variety of protein NMR experiments...
  75. Liang Y, Tang W, Huang T, Gao Y, Tan A, Yang X, et al. Genetic variations affecting serum carcinoembryonic antigen levels and status of regional lymph nodes in patients with sporadic colorectal cancer from Southern China. PLoS ONE. 2014;9:e97923 pubmed publisher
    ..The rs1047781 (chr19- FUT2) (A/T) was associated with elevated sCEA levels, and rs8176746 (chr9- ABO) was associated with the regional lymph metastasis in the CRC patients...
  76. Zhang W, Liu J, Zhang W, Zhuang Y. The potential association of the transcription levels of the ABO gene with the disease phases in AML patients. Transfus Apher Sci. 2017;56:719-722 pubmed publisher
    Patients with AML may show ABO blood typing discrepancy, and the expression levels of the ABO antigens may show some alterations with the disease progression...