ABL2

Summary

Gene Symbol: ABL2
Description: c-abl oncogene 2, non-receptor tyrosine kinase
Alias: ABLL, ARG, Abelson tyrosine-protein kinase 2, abelson-related gene protein, tyrosine-protein kinase ARG, v-abl Abelson murine leukemia viral oncogene homolog 2
Species: human

Top Publications

  1. ncbi Use of beta-lactamase as a secreted reporter of promoter function in yeast
    C P Cartwright
    University of Massachusetts Medical School, Department of Molecular Genetics and Microbiology, Worcester 01655
    Yeast 10:497-508. 1994
  2. ncbi Intestinal expressions of eNOSmRNA and iNOSmRNA in rats with acute liver failure
    J M Qin
    Biological Signal Transduction Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai 200438, China
    World J Gastroenterol 7:652-6. 2001
  3. pmc Reciprocal regulation of Abl and receptor tyrosine kinases
    Divyamani Srinivasan
    Department of Molecular and Biomedical Pharmacology, University of Kentucky School of Medicine, 800 Rose Street, Lexington, KY 40346, USA
    Cell Signal 21:1143-50. 2009
  4. doi c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3
    X Li
    Beijing Institute of Biotechnology, Beijing, China
    Cell Death Differ 17:1277-87. 2010
  5. ncbi ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks
    B Wang
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 272:17542-50. 1997
  6. pmc Mediation by bradykinin of rat paw oedema induced by collagenase from Clostridium histolyticum
    F J Legat
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Br J Pharmacol 112:453-60. 1994
  7. pmc Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitro
    A Dray
    Sandoz Institute for Medical Research, London
    Br J Pharmacol 107:1129-34. 1992
  8. pmc Bradykinin-stimulated phosphoinositide metabolism in cultured canine tracheal smooth muscle cells
    C M Yang
    Department of Pharmacology, Chang Gung Medical College, Kwei San, Tao Yuan, Taiwan
    Br J Pharmacol 111:21-8. 1994
  9. pmc Ca(2+)-dependent and -independent mechanism of cyclic-AMP reduction: mediation by bradykinin B2 receptors
    H Sipma
    Groningen Institute for Drugs Studies GIDS, Department of Clinical Pharmacology, University of Groningen, The Netherlands
    Br J Pharmacol 115:937-44. 1995
  10. ncbi Screening for mutations in the steroidogenic acute regulatory protein and steroidogenic factor-1 genes, and in CYP11A and dosage-sensitive sex reversal-adrenal hypoplasia gene on the X chromosome, gene-1 (DAX-1), in hyperandrogenic hirsute women
    R M Calvo
    Department of Endocrinology, , Madrid 28034, Spain
    J Clin Endocrinol Metab 86:1746-9. 2001

Detail Information

Publications218 found, 100 shown here

  1. ncbi Use of beta-lactamase as a secreted reporter of promoter function in yeast
    C P Cartwright
    University of Massachusetts Medical School, Department of Molecular Genetics and Microbiology, Worcester 01655
    Yeast 10:497-508. 1994
    ..P, a 67 residue 'processing' segment with three sites for N-glycosylation, terminates in a Lys Arg site for cleavage by the Kex2 protease...
  2. ncbi Intestinal expressions of eNOSmRNA and iNOSmRNA in rats with acute liver failure
    J M Qin
    Biological Signal Transduction Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai 200438, China
    World J Gastroenterol 7:652-6. 2001
    ....
  3. pmc Reciprocal regulation of Abl and receptor tyrosine kinases
    Divyamani Srinivasan
    Department of Molecular and Biomedical Pharmacology, University of Kentucky School of Medicine, 800 Rose Street, Lexington, KY 40346, USA
    Cell Signal 21:1143-50. 2009
    Previously, we showed that Abl kinases (c-Abl, Arg) are activated downstream of PDGF in a manner dependent on Src kinases and PLC-gamma1, and promote PDGF-mediated proliferation and migration of fibroblasts...
  4. doi c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3
    X Li
    Beijing Institute of Biotechnology, Beijing, China
    Cell Death Differ 17:1277-87. 2010
    ..This study shows that c-Abl and Abl-related gene (Arg) associate with and phosphorylate Gal3...
  5. ncbi ArgBP2, a multiple Src homology 3 domain-containing, Arg/Abl-interacting protein, is phosphorylated in v-Abl-transformed cells and localized in stress fibers and cardiocyte Z-disks
    B Wang
    Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 272:17542-50. 1997
    b>Arg and c-Abl represent the mammalian members of the Abelson family of protein-tyrosine kinases. A novel Arg/Abl-binding protein, ArgBP2, was isolated using a segment of the Arg COOH-terminal domain as bait in the yeast two-hybrid system...
  6. pmc Mediation by bradykinin of rat paw oedema induced by collagenase from Clostridium histolyticum
    F J Legat
    Department of Experimental and Clinical Pharmacology, University of Graz, Austria
    Br J Pharmacol 112:453-60. 1994
    ..Heat-inactivated collagenase was ineffective. 3. The B2 bradykinin (BK) antagonist icatibant (D-Arg-[Hyp3-Thi5-D-Tic7- Oic8] bradykinin, formerly named Hoe-140) reduced oedema formation in a dose-dependent manner ..
  7. pmc Bradykinin-induced activation of nociceptors: receptor and mechanistic studies on the neonatal rat spinal cord-tail preparation in vitro
    A Dray
    Sandoz Institute for Medical Research, London
    Br J Pharmacol 107:1129-34. 1992
    ..The rank order potency was Hoe 140> LysLys [Hyp3,Thi5 8,D-Phe7]-bradykinin> D-Arg[Hyp3, Thi5'8, D-Phe7]-bradykinin = D-Arg[Hyp2,Thi5'8, D-Phe7]-bradykinin.7...
  8. pmc Bradykinin-stimulated phosphoinositide metabolism in cultured canine tracheal smooth muscle cells
    C M Yang
    Department of Pharmacology, Chang Gung Medical College, Kwei San, Tao Yuan, Taiwan
    Br J Pharmacol 111:21-8. 1994
    ..3 +/- 0.7 nM, (n = 5), respectively. 2. D-Arg[Hyp3, D-Phe7]-BK and D-Arg[Hyp3, Thi5,8, D-Phe7]-BK, B2 receptor antagonists, were equipotent in blocking the BK-..
  9. pmc Ca(2+)-dependent and -independent mechanism of cyclic-AMP reduction: mediation by bradykinin B2 receptors
    H Sipma
    Groningen Institute for Drugs Studies GIDS, Department of Clinical Pharmacology, University of Groningen, The Netherlands
    Br J Pharmacol 115:937-44. 1995
    ..cyclic AMP formation in isoprenaline prestimulated cells, while the bradykinin B2 receptor antagonists, Hoe 140 (D-Arg[Hyp3, Thi5, D-Tic7, Oic8]-BK) and D-Arg[Hyp3, Thi5,8, D-Phe7]-BK completely abolished the bradykinin response in ..
  10. ncbi Screening for mutations in the steroidogenic acute regulatory protein and steroidogenic factor-1 genes, and in CYP11A and dosage-sensitive sex reversal-adrenal hypoplasia gene on the X chromosome, gene-1 (DAX-1), in hyperandrogenic hirsute women
    R M Calvo
    Department of Endocrinology, , Madrid 28034, Spain
    J Clin Endocrinol Metab 86:1746-9. 2001
    ..Two variants were identified in the SF-1 gene. A G-->C change in exon 6, resulting in an Arg(365)Pro mutation, was found in 1 of 45 patients, but not in controls...
  11. pmc Mechanism of bradykinin-induced plasma extravasation in the rat knee joint
    H Cambridge
    Pharmacology Group, King s College London
    Br J Pharmacol 115:641-7. 1995
    ..into the knee which was inhibited by co-perfusion of the selective bradykinin B2 receptor antagonist D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]-bradykinin (Hoe 140, 200 nM). 3...
  12. pmc Bradykinin B1 receptors in the rabbit urinary bladder: induction of responses, smooth muscle contraction, and phosphatidylinositol hydrolysis
    S K Butt
    Biomedical Sciences Division, King s College London, Chelsea
    Br J Pharmacol 114:612-7. 1995
    ..in the bladder were competitively antagonized by the B1 receptor-selective antagonists [Leu8,des-Arg9]-BK and D-Arg-[Hyp3,Thi5,D-Tic7,Oic8,des-Arg9]-BK ([des-Arg10]-Hoe140) (pKB estimates were 6.1 +/- 0.1 and 7.1 +/- 0...
  13. ncbi The long acting human insulin analog HOE 901: characteristics of insulin signalling in comparison to Asp(B10) and regular insulin
    L Berti
    Abteilung IV, Medizinische Klinik und Poliklinik, , Germany
    Horm Metab Res 30:123-9. 1998
    HOE 901 is a new biosynthetic long-acting human insulin analog (GLY[A21]ARG[B31]ARG[B32])...
  14. ncbi [Presence of a specific binding site of endothelin on cultured smooth muscle cells]
    P Roubert
    Institut Henri-Beaufour, Les Ulis, France
    Arch Mal Coeur Vaiss 82:1261-3. 1989
    ..2 nM, whereas an absence of competition was observed with 1 microM of vasoactive substances such as angiotensin II, arg-vasopressin, atrial natriuretic factor, histamine, epinephrine and norepinephrine, and with the calcium entry ..
  15. pmc Bradykinin B2 receptors and coupling mechanisms in the smooth muscle of the guinea-pig taenia caeci
    J L Field
    Biomedical Sciences Division, King s College London, Chelsea, London
    Br J Pharmacol 113:607-13. 1994
    ..The B2 receptor-selective antagonist, D-Arg-[Hyp3,Thi5,D-Tic7,Oic8]-BK (Hoe 140) (30-300 nM), inhibited both the bradykinin-induced relaxation and contraction ..
  16. ncbi New family of glutathionyl-biomimetic ligands for affinity chromatography of glutathione-recognising enzymes
    S C Melissis
    Department of Agricultural Biotechnology, Agricultural University of Athens, Greece
    J Chromatogr A 917:29-42. 2001
    ..biomimetic moiety is primarily achieved by the strong ionic interactions with the Zn2+ ion of FaDH and Arg 114, and by the hydrophobic contacts made with Tyr 92 and Met 140...
  17. ncbi [Biogenesis of peroxisome--targeting signal and peroxisome assembly factor]
    Y Fujiki
    Meiji Institute of Health Science, Kanagawa
    No To Hattatsu 24:181-5. 1992
    ..Further experiments have strongly suggested that the SKL motif, Ser/Ala-Lys/Arg/His-Leu-COOH commonly found at C-termini of many peroxisomal proteins, functions as a peroxisome-targeting signal...
  18. pmc Role of platelet-activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long-acting PAF antagonist, UK-74,505
    F Pons
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 109:234-42. 1993
    ..BK), histamine, formyl-methionyl-leucylphenylalanine (FMLP), zymosan-activated plasma (ZAP, as a source of C5a des Arg), leukotriene B4 (LTB4) or interleukin-8 (IL-8). 4. UK-74,505, administered i.v...
  19. ncbi Plasmodium falciparum in Kenya: high prevalence of drug-resistance-associated polymorphisms in hospital admissions with severe malaria in an epidemic area
    S A Omar
    Centre for Biotechnology Research Development, Kenya Medical Research Institute, P O Box 54840, Mbagathi Road, Nairobi, Kenya
    Ann Trop Med Parasitol 95:661-9. 2001
    ..samples also had the mutations associated with resistance to pyrimethamine and sulfadoxine: (Asn)51(Ile), (Cys)59(Arg) and (Ser)108(Asn) of gene dhfr (chromosome 4) and (Ala)437(Gly) and (Lys)540(Glu) of dhps (chromosome 8), ..
  20. ncbi Integration of the multiple controls regulating the expression of the arginase gene CAR1 of Saccharomyces cerevisiae in response to differentnitrogen signals: role of Gln3p, ArgRp-Mcm1p, and Ume6p
    E Dubois
    Institut de Recherches du CERIA, , Brussels, Belgium
    Mol Gen Genet 253:568-80. 1997
    ..The UAS(arg), containing the previously defined "arginine boxes" is the region that responds to the inducer through the action ..
  21. pmc The kinin B1 receptor antagonist des-Arg9-[Leu8]bradykinin: an antagonist of the angiotensin AT1 receptor which also binds to the AT2 receptor
    D Pruneau
    Centre de Recherche, Laboratoires Fournier S C A, Daix, France
    Br J Pharmacol 114:115-8. 1995
    ..Values of Ki for des-Arg9-[Leu8]BK, des-Arg10-[Leu9]KD, des-Arg9-BK, des-Arg 10-KD and KD were 0.3 +/- 0.1, 0.7 +/- 0.1, 1.2 +/- 0.3, 1.5 +/- 0.3 and 7.0 +/- 1.6 microM, respectively. 6...
  22. pmc Support of renal blood flow after ischaemic-reperfusion injury by endogenous formation of nitric oxide and of cyclo-oxygenase vasodilator metabolites
    J P Cristol
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 109:188-94. 1993
    ..v., n = 4) significantly enhanced the rise in RVR associated with I/R injury. 4. Infusion of L-arginine (L-Arg; 1 or 3 mg kg-1 min-1, i.v., n = 5 and 4, respectively) or D-Arg (1 mg kg-1 min-1, i.v...
  23. ncbi Cloning and sequence analyses of cDNAs encoding vasotocin and isotocin precursors of chum salmon, Oncorhynchus keta: evolutionary relationships of neurohypophysial hormone precursors
    S Hyodo
    Laboratory of Physiology, University of Tokyo, Nakano
    J Comp Physiol B 160:601-8. 1991
    ..sIT precursors were found to contain a signal peptide and hormone that is connected to a neurophysin by a Gly-Lys-Arg sequence...
  24. pmc The use of synthetic analogues of Arg-Gly-Asp (RGD) and soluble receptor of tumor necrosis factor to prevent acute and chronic experimental liver injury
    R Bruck
    Department of Gastroenterology, E. Wolfson Medical Center, Holon, Israel
    Yale J Biol Med 70:391-402. 1997
    ..The target epitope of several such integrin receptors is the Arg-Gly-Asp (RGD) sequence, a cell adhesion motif shared by several matrix-associated adhesive glycoproteins...
  25. ncbi Liquid chromatographic determination of D- and L-amino acids by derivatization with o-phthaldialdehyde and N-isobutyryl-L-cysteine. Applications with reference to the analysis of peptidic antibiotics, toxins, drugs and pharmaceutically used amino acids
    H Bruckner
    Institute of Food Technology, University of Hohenheim, Stuttgart, Germany
    J Chromatogr A 711:201-15. 1995
    ..bacitracin, gramicidins A and S, polymyxin B, metanicin C, the peptide toxin malformin A and the peptide drugs D-Arg-[Hyp3,Thi5,8,D-Phe7]-bradykinin, beta-casomorphin and alpha s1-exorphin...
  26. pmc Effects of bradykinin receptor antagonists on antigen-induced respiratory distress, airway hyperresponsiveness and eosinophilia in guinea-pigs
    S G Farmer
    Nova Pharmaceutical Corporation, Baltimore, Maryland 21224
    Br J Pharmacol 107:653-9. 1992
    ..A B2 receptor antagonist, D-Arg-[Hyp3, Thi5,8,D-Phe7]-BK (NPC 349) had a small, but statistically significant inhibitory effect on responsiveness ..
  27. pmc NH2-terminal substitutions of basic amino acids induce translocation across the microsomal membrane and glycosylation of rabbit cytochrome P450IIC2
    E Szczesna-Skorupa
    Department of Physiology and Biophysics, University of Illinois, Urbana 61801
    J Cell Biol 108:1237-43. 1989
    Insertion of rabbit cytochrome P450IIC2 and its modified form, [2-lys,3-arg]P450IIC2, into microsomal membranes was studied in an in vitro transcription/translation/translocation system...
  28. pmc Differential effects of B2 receptor antagonists upon bradykinin-stimulated phospholipase C and D in guinea-pig cultured tracheal smooth muscle
    S Pyne
    Department of Physiology and Pharmacology, University of Strathclyde, Royal College, Glasgow
    Br J Pharmacol 110:477-81. 1993
    ..Bradykinin-stimulated (10 nM, EC40) Ins(1,4,5)P3 formation was inhibited by B2 receptor antagonists, D-Arg-[Hyp3,D-Phe7]-bradykinin (NPC 567) and D-Arg-[Hyp3,Thi5,8,D-Phe7]-bradykinin (NPC 349), with log IC50 values of -6...
  29. ncbi Sensitive determination of N-terminal prolyl peptides by high-performance liquid chromatography with laser-induced fluorescence detection
    M Ishibashi
    Division of Drugs, National Institute of Health Sciences, Tokyo, Japan
    J Chromatogr A 661:105-12. 1994
    ..hormone), Pro-Thr-Pro-Ser-NH2 (IgA1 proteinase inhibitor) and Pro-Asp-Val-Asp-His-Val- Phe-Leu-Arg-Phe-NH2 [FMRF amide-like (Phe-Met-Arg-Phe-NH2) neuropeptide], were well separated by reversed-phase HPLC with water-..
  30. pmc Cutaneous permeability responses to bradykinin and histamine in the guinea-pig: possible differences in their mechanism of action
    W Paul
    Department of Pharmacology, King s College, London
    Br J Pharmacol 111:159-64. 1994
    ..1 mumol/site) on the response to BK but not on that to histamine was significantly reversed by L-arginine (L-Arg; 10 mumol/site). D-arginine (D-Arg; 10 mumol/site) had no significant effect in either case. 5...
  31. ncbi [Chronic and acute effect of cycletanine in NO-dependent hypertensive pregnant rats]
    B Van Overloop
    CNRS URA 60, , , Illkirch-Graffenstaden
    Arch Mal Coeur Vaiss 88:1223-7. 1995
    ..enriched diet produced hypertension we measured in vivo cardiovascular responses to PGF2 alpha, L-arginine (L-arg) and cicletanine (Cic, IPSEN, France) which enhances PGI2 production...
  32. ncbi Nitric oxide in cyclosporine A-induced hypertension: role of protein kinase C
    G K Oriji
    Hypertension-Endocrine Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA
    Am J Hypertens 12:1091-7. 1999
    ..The effects of CsA were reversed both in vivo and in vitro by pretreatment with L-arginine (L-Arg; 10 mg/kg/day intraperitoneally), the precursor of NO...
  33. ncbi [Homologous and heterologous regulations of endothelin receptors on smooth muscle cells]
    P Roubert
    Institut Henri-Beaufour, Les Ulis, France
    Arch Mal Coeur Vaiss 83:1183-5. 1990
    ..On the same conditions, Arg-vasopressin (1 microM) was able to down-regulate ET-1 receptors by less than 30 p...
  34. ncbi Glutamate 83 is important for stabilization of domain-domain conformation of Thermus aquaticus glycerol kinase
    H S Huang
    School of Pharmaceutical Sciences, Nagasaki University, Bunkyo-machi, Nagasaki 852-8521, Japan
    J Biochem 128:207-11. 2000
    ..Three residues (Arg-82, Glu-83, and Asp-244) of T...
  35. ncbi Rat tripeptidyl peptidase I: molecular cloning, functional expression, tissue localization and enzymatic characterization
    P G Du
    Department of Medical Biochemistry, Shiga University of Medical Science, Seta, Otsu, Japan
    Biol Chem 382:1715-25. 2001
    ..TPP I released the tripeptide Arg-Val-Tyr from angiotensin III more rapidly than from Ala-Ala-Phe-MCA, and also released Gly-Asn-Leu from neuromedin ..
  36. ncbi Release of proteins and polysaccharides from the albumen gland of the freshwater snail Helisoma duryi: effect of cAMP and brain extracts
    F Morishita
    Zoological Institute, Faculty of Science, Hiroshima University, Higashi, Japan
    J Comp Physiol A 182:817-25. 1998
    ..The neuroactive agents serotonin, Phe-Met-Arg-Phe-amide, Tyr-Gly-Gly-Phe-Met-Arg-Phe-amide, small cardioactive peptide B, and caudodorsal cell hormone were also ..
  37. ncbi [Response of the coronary arteries to cold test and flow velocity increase is improved by deferoxamine but not by L-arginine in diabetic patients]
    A Nitenberg
    Service de Physiologie et d'Explorations Fonctionnelles, INSERM U 426, , Colombes
    Arch Mal Coeur Vaiss 90:1037-41. 1997
    ..v. L-arginine (L-arg, 625 mg/min x 10 min) or i.v...
  38. ncbi Blunted GH response to growth hormone-releasing hormone (GHRH) alone or combined with arginine in non-insulin-dependent diabetes mellitus
    V Martina
    Dipartimento di Fisiopatologia Clinica, , Italy
    Horm Metab Res 27:26-30. 1995
    ..OD), we investigated the somatotrope responsiveness to GHRH (1 microgram/kg) alone or combined with arginine (ARG, 0...
  39. ncbi Enhanced sensitivity for peptide mapping with electrospray liquid chromatography-mass spectrometry in the presence of signal suppression due to trifluoroacetic acid-containing mobile phases
    A Apffel
    Bay Analytical Operation, Hewlett-Packard Co, Palo Alto, CA 94304, USA
    J Chromatogr A 712:177-90. 1995
    ..A third application demonstrates the identification of glycosylation sites in an endoproteinase Arg C digest of single-chain plasminogen activator through the use of in-source collisionally induced dissociation.
  40. pmc Differential effects of the PAF receptor antagonist UK-74,505 on neutrophil and eosinophil accumulation in guinea-pig skin
    M J Sanz
    Department of Applied Pharmacology, National Heart and Lung Institute, London
    Br J Pharmacol 113:513-21. 1994
    ..on responses elicited by leukotriene B4 (LTB4) and zymosan-activated plasma (ZAP, used as a source of C5a des Arg). UK-74,505 (2...
  41. pmc Clots of beta-fibrin. Viscoelastic properties, temperature dependence of elasticity, and interaction with fibrinogen-binding tetrapeptides
    A Shimizu
    Department of Chemistry, University of Wisconsin, Madison 53706
    Biophys J 53:311-8. 1988
    ..Introduction (by diffusion) of the tetrapeptides Gly-His-Arg-Pro (GHRP) and Gly-Pro-Arg-Pro (GPRP), which resemble the B and A binding sites on the E domain of fibrin ..
  42. ncbi Abnormal polymerization and normal binding of plasminogen and t-PA in three new dysfibrinogenaemias: Barcelona III and IV (gamma Arg 275-->His) and Villajoyosa (gamma Arg 275-->Cys)
    M Borrell
    , Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Blood Coagul Fibrinolysis 6:198-206. 1995
    ..The altered properties observed in fibrin monomers produced from fibrinogen with the gamma Arg 275-->His or gamma Arg 275-->Cys substitution, suggests that this amino acid is important in maintaining the ..
  43. ncbi A yeast protein that bidirectionally affects nucleocytoplasmic transport
    D R Singleton
    Institute of Pathology, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Cell Sci 108:265-72. 1995
    ..J. Cell Biol. 119, 737-747). NPL3 includes bipartite RNA recognition motifs (RRM) and a Gly-Arg repeat domain, as in several nucleolar proteins...
  44. ncbi Peptide chiral purity determination: hydrolysis in deuterated acid, derivatization with Marfey's reagent and analysis using high-performance liquid chromatography-electrospray ionization-mass spectrometry
    D R Goodlett
    Immunobiology Research Institute, Annandale, NJ 08801, USA
    J Chromatogr A 707:233-44. 1995
    ..This procedure was used to determine the chiral purity of each amino acid in a purified, hexapeptide by-product (Arg-Lys-Lys-Asp-Val-Tyr) present in a kilogram batch of the synthetic pentapeptide, thymopentin (Arg-Lys-Asp-Val-Tyr).
  45. pmc Characterization of beta-galactosidase mutations Asp332-->Asn and Arg148-->Ser, and a polymorphism, Ser532-->Gly, in a case of GM1 gangliosidosis
    S Zhang
    Research Institute, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, Canada M5G 1X8
    Biochem J 348:621-32. 2000
    ..converts Asp(332) into asparagine, and both a mutation (C492-->A in exon 4, leading to the amino acid change of Arg(148)-->Ser) and a polymorphism (A1644-->G in exon 15, leading to a change of Ser(532)-->Gly) on the other ..
  46. ncbi Analysis of two mutated vacuolar proteins reveals a degradation pathway in the endoplasmic reticulum or a related compartment of yeast
    A Finger
    , , Germany
    Eur J Biochem 218:565-74. 1993
    ..Mutant CPY carries an Arg instead of a Gly residue in a highly conserved region, two positions distant from the active-site Ser...
  47. ncbi Melanocortins and cardiovascular regulation
    D H Versteeg
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, Netherlands
    Eur J Pharmacol 360:1-14. 1998
    ..of pro-opiomelanocortin-derived peptides that have the melanocyte-stimulating hormone (MSH) core sequence, His-Phe-Arg-Trp, in common. Melanocortins have been described as having a variety of cardiovascular effects...
  48. pmc A recombinant hybrid anaphylatoxin with dual C3a/C5a activity
    W Bautsch
    Institute of Medical Microbiology, Hanover Medical School, Germany
    Biochem J 288:261-6. 1992
    ..sequence of human C5a were exchanged to create the native C-terminal human C3a (hC3a) sequence Leu-Gly-Leu-Ala-Arg. This hybrid anaphylatoxin rC5a-(1-69)-LGLAR exhibited true C3a and C5a activity when tested in the guinea pig ..
  49. ncbi A kallikrein-like enzyme in human vascular tissue
    P Madeddu
    Clinica Medica, Sassari University, Italy
    Am J Hypertens 6:344-8. 1993
    ..for protein content and for active and total (trypsin activation) enzymatic activity on the peptide H-D-Val-Leu-Arg-paranitroanilide (S2266), a synthetic substrate for glandular kallikrein...
  50. ncbi Stability of o-phthalaldehyde-sulfite derivatives of amino acids and their methyl esters: electrochemical and chromatographic properties
    G Turiak
    Department of Pharmacology, Boston University School of Medicine, MA 02118
    J Chromatogr A 668:323-9. 1994
    ..detection was used to monitor the decomposition of five amino acid o-phthalaldehyde (OPA)-sulfite derivatives (Ala, Arg, Glu, Ser, Tyr) and their methyl ester derivatives as well...
  51. ncbi Substitutions at the P(1) position in BPTI strongly affect the association energy with serine proteinases
    A Grzesiak
    Protein Engineering Laboratory, Institute of Biochemistry and Molecular Biology, University of Wroclaw, Tamka 2, Wroclaw, 50-137, Poland
    J Mol Biol 301:205-17. 2000
    ..seven different mutants of bovine pancreatic trypsin inhibitor (BPTI); the mutants contain Gly, Ala, Ser, Val, Leu, Arg, and Trp at the P(1) position of the reactive site...
  52. pmc A ubiquitin mutant with specific defects in DNA repair and multiubiquitination
    J Spence
    Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115
    Mol Cell Biol 15:1265-73. 1995
    ..chains, we examined the effects of individually substituting each of six other Lys residues in ubiquitin with Arg. Substitution of Lys-63 resulted in the disappearance of a family of abundant multiubiquitin-protein conjugates...
  53. ncbi De novo design, synthesis, and pharmacology of alpha-melanocyte stimulating hormone analogues derived from somatostatin by a hybrid approach
    Guoxia Han
    Departments of Chemistry and Anatomy, University of Arizona, Tucson, Arizona 85721, USA
    J Med Chem 47:1514-26. 2004
    ..CTAP which binds specifically to micro opioid receptors, and the core pharmacophore of alpha-MSH (His-Phe-Arg-Trp)...
  54. pmc Characteristics of the bradykinin-induced changes in intracellular calcium ion concentration of single bovine tracheal smooth muscle cells
    K A Marsh
    Department of Physiology and Pharmacology, University of Nottingham Medical School, Queen s Medical Centre
    Br J Pharmacol 110:29-35. 1993
    ..7 M) in the presence of extracellular calcium ions (2 mM). The bradykinin B2 receptor antagonist, D-Arg[Hyp3,Thi5,8,D-Phe7]- bradykinin, produced a parallel shift to the right of the bradykinin concentration-response ..
  55. ncbi Total resolution of 17 DL-amino acids labelled with a fluorescent chiral reagent, R(-)-4-(3-isothiocyanatopyrrolidin-1-y1)-7-(N,N-dimethylaminosulfonyl)- 2,1,3-benzoxadiazole, by high-performance liquid chromatography
    D Jin
    Department of Analytical Chemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan
    J Chromatogr A 822:215-24. 1998
    ..Peak resolution was in the range of 0.92 (DL-Arg)-9.8 (DL-Cys)...
  56. pmc Differential effects of lumenal L-arginine and NG-nitro L-arginine on blood flow and water fluxes in rat ileum
    D Mailman
    Biology Department, University of Houston, TX 77204
    Br J Pharmacol 112:304-10. 1994
    ..NO) in the local regulation of H2O absorption and blood flow in rat ileum was studied by perfusing L-arginine (L-Arg) (0.1-1.0 mM) and NG-nitro L-arginine (L-NOARG) (0.01-1.0 mM) through the lumen...
  57. pmc Inhibitory actions of diphenyleneiodonium on endothelium-dependent vasodilatations in vitro and in vivo
    Y X Wang
    Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada
    Br J Pharmacol 110:1232-8. 1993
    ..relaxation was prevented by pretreatment with NADPH (5 x 10(-3) M) and FAD (5 x 10(-4) M) but not L-arginine (L-Arg, 2 x 10(-3) M)...
  58. ncbi A stretch of positively charged amino acids at the N terminus of Hansenula polymorpha Pex3p is involved in incorporation of the protein into the peroxisomal membrane
    R J Baerends
    Eukaryotic Microbiology, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, 9751 NN Haren, The Netherlands
    J Biol Chem 275:9986-95. 2000
    ..Here, we show that a conserved stretch of positively charged amino acids (Arg(11)-X-Lys-Lys-Lys(15)) in the N terminus of Hansenula polymorpha Pex3p is involved in incorporation of the protein ..
  59. ncbi Porin of Rhodobacter capsulatus: biochemical and functional characterization
    D Woitzik
    , Mikrobiologie, , Freiburg, Bundesrepublik Deutschland
    Z Naturforsch C 45:576-82. 1990
    ..0, was obtained on isoelectric focusing. Gas-phase sequencing of the 23 N-terminal residues revealed Glu-Val-Lys-Leu-Ser-Gly-Asp-Ala-Arg-Met-Gly-Val-Met-Tyr-Asn-Gly-Asp-Asp- X-Asn- Phe-Ser-Ser.
  60. ncbi Modulation by APGW-amide, an Achatina endogenous inhibitory tetrapeptide, of currents induced by neuroactive compounds on Achatina neurons: peptides
    X Y Han
    Department of Physiology, Gifu University School of Medicine, Japan
    Gen Pharmacol 29:531-8. 1997
    ..2. Outward current (Iout) caused by FMRFamide (Phe-Met-Arg-Phe-NH2) on v-RCDN, which was probably K+ dependent, was inhibited with membrane conductance (g) increase by APGW-..
  61. ncbi In the absence of endogenous mouse apolipoprotein E, apolipoprotein E*2(Arg-158 --> Cys) transgenic mice develop more severe hyperlipoproteinemia than apolipoprotein E*3-Leiden transgenic mice
    B J van Vlijmen
    TNO Prevention and Health, Gaubius Laboratory, 2301 CE Leiden, The Netherlands
    J Biol Chem 271:30595-602. 1996
    Apolipoprotein E*2(Arg-158 --> Cys) (APOE*2) transgenic mice were generated and compared to the previously generated apolipoprotein E*3-Leiden (APOE*3-Leiden) transgenic mice to study the variable expression of hyperlipoproteinemia ..
  62. ncbi Dietary L-arginine supplementation normalizes regional blood flow in Dahl-Iwai salt-sensitive rats
    H He
    Department of Pharmacology, Kagawa Medical School, Miki-cho, Kita-gun, Japan
    Am J Hypertens 10:89S-93S. 1997
    ..One group (S or R rats) was maintained on tap water and the other group (S/Arg) of S rats received tap water containing L-arginine at a concentration of 1.5%...
  63. ncbi Transition from argatroban to oral anticoagulation with phenprocoumon or acenocoumarol: effects on prothrombin time, activated partial thromboplastin time, and Ecarin Clotting Time
    Sebastian Harder
    Pharmazentrum Frankfurt, Institute for Clinical Pharmacology, University Hospital, Frankfurt am Main, Germany
    Thromb Haemost 91:1137-45. 2004
    Treatment with the direct thrombin inhibitor argatroban (ARG) is often followed by vitamin K-antagonist treatment (VKA). Phenprocoumon (PC) and acenocoumarol (AC) are frequently used in Europe...
  64. ncbi An 18.3 kb DNA fragment from yeast chromosome VII carries four unknown open reading frames, the gene for an Asn synthase, remnants of Ty and three tRNA genes
    L van Dyck
    , , Louvain la Neuve, Belgium
    Yeast 13:171-6. 1997
    ..The segment also contains tRNA genes for Asn, Arg and Ile as well as sigma element and two solo deltas...
  65. ncbi Trp64Arg mutation of beta3-adrenergic receptor in essential hypertension: insulin resistance and the adrenergic system
    T Fujisawa
    Department of Geriatric Medicine, Osaka University Medical School, Japan
    Am J Hypertens 10:101-5. 1997
    ..The allele frequency of the mutation (Arg) in patients with essential hypertension was similar to that in control subjects (35 of 202 alleles [17...
  66. ncbi Involvement of mechanisms dependent on NMDA receptors, nitric oxide and protein kinase A in the hippocampus but not in the caudate nucleus in memory
    J Quevedo
    , Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil
    Behav Pharmacol 8:713-7. 1997
    The effects of the NMDA receptor antagonist AP5, the nitric oxide synthase (NO) inhibitor NO-arg or the protein kinase A (PKA) inhibitor KT5720 on memory were evaluated...
  67. ncbi Processing of C-terminal lysine and arginine residues of proteins isolated from mammalian cell culture
    R J Harris
    Analytical Chemistry Department, Genentech, Inc, South San Francisco, CA 94080, USA
    J Chromatogr A 705:129-34. 1995
    C-terminal Lys or Arg residues whose presence was expected based on gene sequence information are often absent in proteins isolated from mammalian cell culture...
  68. ncbi Selection and characterization of amino acid substitutions at residues 237-240 of TEM-1 beta-lactamase with altered substrate specificity for aztreonam and ceftazidime
    C Cantu
    Structural and Computational Biology and Molecular Biophysics Program, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 271:22538-45. 1996
    ..exhibited a Gly for Ala substitution at position 237, a Ser for Gly substitution at position 238, and a Lys/Arg for Glu at position 240...
  69. ncbi [Prognosis and evaluation of drug therapy by V3 and RT gene analysis of HIV-1]
    M Morimoto
    Osaka Prefectural Institute of Public Health, Japan
    Kansenshogaku Zasshi 70:347-53. 1996
    ..HIV-1 from a patient who had rapidly taken a turn for the worse had basic amino acid at position 11 (Arg) and lost an acidic amino acid at position 25 (Gln) of V3...
  70. pmc Differences in substrate and inhibitor sequence specificity of human, mouse and rat tissue kallikreins
    Sandro E Fogaça
    Department of Biophysics, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rua Tres de Maio 100, São Paulo 04044 20, Brazil
    Biochem J 380:775-81. 2004
    ..Bradykinin was released from these peptides by the mK1- and rK1-mediated hydrolysis of Arg-Arg and Arg-Ser (or Arg-Ala) peptide bonds...
  71. ncbi Effects of L-arginine and furosemide on blood pressure and renal function in volume-expanded rats
    M A Costa
    Catedra de Fisiologia, Departamento de Ciencias Biologicas, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junin 956, Capital Federal, Buenos Aires, Argentina
    Clin Exp Pharmacol Physiol 28:528-32. 2001
    1. The aim of the present study was to investigate the effects of L-arginine (L-Arg) on blood pressure and water and electrolyte excretion in control and extracellular fluid volume-expanded rats (10% bodyweight with 0...
  72. pmc Potentiation of the vasorelaxant activity of nitric oxide by hydroxyguanidine: implications for the nature of endothelium-derived relaxing factor
    A Zembowicz
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 107:1001-7. 1992
    ..These relaxations were inhibited by NG-nitro-L-arginine methyl ester (L-NAME, 10 microM) and L-arginine (L-Arg, 1 mM) reversed the inhibitory effects of L-NAME. 7...
  73. ncbi Two novel mutations in the gonadotropin-releasing hormone receptor gene in Brazilian patients with hypogonadotropic hypogonadism and normal olfaction
    E M Costa
    Unidade de Endocrinologia do Desenvolvimento e Laboratório de Hormônios e Genética Molecular LIM 42, da Disciplina de Endocrinologia do Hospital das Clínicas da Faculdade de Medicina da Universidade de Sao Paulo, Sao Paulo 01060 970, Brazil
    J Clin Endocrinol Metab 86:2680-6. 2001
    ..A novel missense mutation, Arg(139)His, located in the conserved DRS motif at the junction of the third transmembrane and the second intracellular ..
  74. pmc Interaction of classical swine fever virus with membrane-associated heparan sulfate: role for virus replication in vivo and virulence
    M M Hulst
    Institute for Animal Science and Health, Research Branch Houtribweg, NL 8200 AB Lelystad, The Netherlands
    J Virol 75:9585-95. 2001
    ..A Ser-to-Arg change in the C terminus of envelope glycoprotein E(rns) (amino acid 476 in the open reading frame of CSFV) is ..
  75. ncbi Effects of arginine on pancreatic hormones and hepatic metabolism in rainbow trout
    T P Mommsen
    Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia V8W 3P6, Canada
    Physiol Biochem Zool 74:668-78. 2001
    Arginine (Arg), injected intraperitoneally into rainbow trout (Oncorhynchus mykiss), increases plasma concentrations of glucagon, glucagon-like peptide-1 (GLP-1), and insulin by three- to 10-fold...
  76. pmc Biochemical enrichment and biophysical characterization of a taste receptor for L-arginine from the catfish, Ictalurus puntatus
    William Grosvenor
    Monell Chemical Senses Center, Philadelphia, PA 19104 3308, USA
    BMC Neurosci 5:25. 2004
    ..Many of these receptors are sensitive to selected amino acids, one of these being a receptor for L-arginine (L-Arg)...
  77. ncbi Mechanisms that regulate the anticoagulant function of coagulation factor V
    E Thorelli
    Department of Clinical Chemistry, Lund University, University Hospital Malmo, Sweden
    Scand J Clin Lab Invest Suppl 229:19-26. 1999
    ..factor V is composed of domains A1-A2-B-A3-C1-C2 and is activated by thrombin through proteolytic cleavage at Arg 709, Arg 1018 and Arg 1545...
  78. pmc Arg-27, Arg-127 and Arg-155 in the beta-trefoil protein barley alpha-amylase/subtilisin inhibitor are interface residues in the complex with barley alpha-amylase 2
    K W Rodenburg
    Carlsberg Laboratory, Department of Chemistry, Copenhagen, Denmark
    Biochem J 309:969-76. 1995
    ..fragments of labelled BASI were purified by reverse-phase HPLC, and we concluded that the radiolabelled Arg-27, Arg-155 and most likely Arg-127, identified by amino acid, sequence and 14C analyses, are protected by AMY2...
  79. ncbi hOGG1 Ser326Cys and XRCC1 Arg399Gln polymorphisms associated with chronic obstructive pulmonary disease
    Shi fang Yang
    Department of Respiratory Medicine, Tongji Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Chin Med J (Engl) 122:960-6. 2009
    ..e., part of them develop COPD. We investigated the association between polymorphisms in DNA repair genes hOGG1 (Ser326Cys) and XRCC1 (Arg399Gln), alone or in combination, and susceptibility of COPD...
  80. ncbi Growth and immunity of broiler chicks as affected by dietary arginine
    M T Kidd
    Department of Poultry Science, Mississippi State University, MS 39762, USA
    Poult Sci 80:1535-42. 2001
    A dietary deficiency of Arg may suppress chick immune system functions; however, research evaluating immune function responsiveness of commercial broilers fed dietary Arg levels near NRC (1994) recommendations is sparse...
  81. ncbi [Autoradiography reporter gene (Ad5-tk carrying HSV1-tk gene) expression imaging in rat myocardium]
    Ying Liu
    Department of Nuclear Medicine, Union Hospital, Huazhong University of Science and Technology, Hubei Key Laboratory of Molecular Imaging, Wuhan 430022, China
    Zhonghua Xin Xue Guan Bing Za Zhi 37:925-30. 2009
    ..We explored the feasibility of the expression imaging of HSV1-tk reporter gene in rat myocardium by using SPECT reporter probe (131)I-2'-fluoro-2'-deoxy-1-beta-D-arabinofuranosyl-5-iodouracil ((131)I-FIAU) and autoradiography (ARG).
  82. pmc Effect of beta2-adrenergic receptor polymorphism on response to longacting beta2 agonist in asthma (LARGE trial): a genotype-stratified, randomised, placebo-controlled, crossover trial
    Michael E Wechsler
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Lancet 374:1754-64. 2009
    ..with asthma who are homozygous for arginine at the 16th amino acid position of the beta2-adrenergic receptor (B16 Arg/Arg) benefit less from treatment with longacting beta2 agonists and inhaled corticosteroids than do those ..
  83. doi Arginine-enriched total parenteral nutrition improves survival in peritonitis by normalizing NFkappaB activation in peritoneal resident and exudative leukocytes
    Chikara Ueno
    Department of Surgery, National Defense Medical College, Saitama, Japan
    Ann Surg 251:959-65. 2010
    ..We hypothesized that arginine (ARG)-enriched parenteral nutrition would normalize NFkappaB activation in peritoneal leukocytes, thereby improving the ..
  84. doi Development of a wound dressing composed of hyaluronic acid sponge containing arginine and epidermal growth factor
    Yasuhiro Matsumoto
    R and D Center for Artificial Skin, School of Allied Health Sciences, Kitasato University, 1 15 1 Kitasato, Sagamihara, Kanagawa 228 8555, Japan
    J Biomater Sci Polym Ed 21:715-26. 2010
    ..Each spongy sheet was immersed into an aqueous solution of LMW-HA containing arginine (Arg) alone or both Arg and epidermal growth factor (EGF), and were then freeze-dried to prepare two types of product...
  85. doi Copper(II) complexes of L-arginine as netropsin mimics showing DNA cleavage activity in red light
    Ashis K Patra
    Department of Inorganic and Physical Chemistry, Indian Institute of Science, Bangalore 560 012, India
    Inorg Chem 48:2932-43. 2009
    Copper(II) complexes [Cu(L-arg)(2)](NO(3))(2) (1) and [Cu(L-arg)(B)Cl]Cl (2-5), where B is a heterocyclic base, namely, 2,2'-bipyridine (bpy, 2), 1,10-phenanthroline (phen, 3), dipyrido[3,2-d:2',3'-f]quinoxaline (dpq, 4), and dipyrido[3,..
  86. ncbi In vivo kinetics of human apolipoprotein A-I variants in rabbits
    K Saku
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    Eur J Clin Invest 29:196-203. 1999
    ..In this study, we investigated the in vivo kinetics of several human apo A-I variants, which we had identified previously, in rabbits...
  87. pmc Evidence for participation of B1 and B2 kinin receptors in formalin-induced nociceptive response in the mouse
    C R Correa
    Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Florianopolis SC, Brazil
    Br J Pharmacol 110:193-8. 1993
    ..Similar results were obtained with the B2 antagonists NPC 349 (D-Arg[Hyp3,Thi5,8-D-Phe7]-BK) and NPC 567 (D-Arg[Hyp3, D-Phe7]-BK) (0.2 and 0.6 nmol/paw)...
  88. ncbi Synergistic therapeutic potential of dexamethasone and L-arginine in lipopolysaccharide-induced septic shock
    Saurabh Chatterjee
    Immunology and Hyperthermia Section, Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Trombay, Mumbai, India
    J Surg Res 140:99-108. 2007
    ..L-arginine (L-arg), a semi-essential amino acid, depending on its metabolic pathway, becomes very essential in stress situations such ..
  89. doi Mass spectrometric characterization of modifications to angiotensin II by lipid peroxidation products, 4-oxo-2(E)-nonenal and 4-hydroxy-2(E)-nonenal
    Seon Hwa Lee
    Department of Bioanalytical Chemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba ku, Sendai, Japan
    Chem Res Toxicol 23:1771-85. 2010
    The octapeptide angiotensin II (Ang II; Asp(1)-Arg(2)-Val(3)-Tyr(4)-Ile(5)-His(6)-Pro(7)-Phe(8)) is the primary active hormone of the renin/angiotensin system (RAS) and has been implicated in various cardiovascular diseases...
  90. ncbi The tRNA-dependent activation of arginine by arginyl-tRNA synthetase requires inter-domain communication
    M Lazard
    Laboratoire d Enzymologie et Biochimie Structurales, UPR 9063 du Centre National de la Recherche Scientifique, Gif sur Yvette, 91190, France
    J Mol Biol 302:991-1004. 2000
    ..A conditional lethal mutant of Chinese hamster ovary cells that exhibits reduced arginyl-tRNA synthetase activity (Arg-1), and two of its derived revertants (Arg-1R4 and Arg-1R5) were analyzed at the structural and functional levels...
  91. ncbi A multitracer stable isotope quantification of the effects of arginine intake on whole body arginine metabolism in neonatal piglets
    Kristine L Urschel
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada
    Am J Physiol Endocrinol Metab 293:E811-8. 2007
    ..and femoral vein catheters for blood sampling, received a complete diet for 2 days and then either a generous (+Arg; 1.80 g x kg(-1) x day(-1); n = 5) or deficient (-Arg; 0.20 g.kg(-1).day(-1); n = 5) arginine diet for 5 days...
  92. ncbi The role of nitric oxide in edema formation in L-arginine-induced acute pancreatitis
    Tamas Takacs
    First Department of Medicine, Faculty of Medicine, University of Szeged, Szeged, Hungary
    Pancreas 25:277-82. 2002
    ..Nitric oxide (NO) has been implicated in the regulation of the pancreatic circulation, the promotion of the capillary integrity, and the inhibition of leukocyte adhesion...
  93. ncbi Potent cyclic peptide inhibitors of VLA-4 (alpha4beta1 integrin)-mediated cell adhesion. Discovery of compounds like cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) compatible with depot formulation
    A S Dutta
    AstraZeneca, Macclesfield, Cheshire, UK
    J Pept Sci 6:398-412. 2000
    ..Many of the peptides like cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) (17), cyclo(MeIle-Leu-Asp-Val-D-Arg-D-Arg-D-Phe) (20), cyclo(MeIle-Leu-Asp-Val-D-Arg-D-Arg-MePhe) (..
  94. ncbi Peptide and non-peptide bradykinin B2 receptor agonists and antagonists: a reappraisal of their pharmacology in the guinea-pig ileum
    S Meini
    Pharmacology Department, Menarini Ricerche S p A, via Rismondo 12 A, 50135, Florence, Italy
    Eur J Pharmacol 409:185-94. 2000
    We have compared the pharmacology of different antagonists, Icatibant (H-DArg-Arg-Pro-Hyp-Gly-Thi-Ser-DTic-Oic-Arg-OH), MEN 11270 (H-DArg-Arg-Pro-Hyp-Gly-Thi-c(Dab-DTic-Oic-Arg)c(7 gamma-10 alpha)), and FR173657 ((E)-3-(6-acetamido-3-..
  95. ncbi Site-directed mutagenesis and structure-function analysis of the human apolipoprotein A-I. Relation between lecithin-cholesterol acyltransferase activation and lipid binding
    A Minnich
    Department of Medicine, Boston University School of Medicine, Massachusetts 02118
    J Biol Chem 267:16553-60. 1992
    ..Point mutations were introduced which changed Gln-1, Gln-2 to Arg,Arg, Pro99 to His, and Pro121 to His...
  96. doi Interaction of acetylcholinesterase with the G4 domain of the laminin alpha1-chain
    Glynis Johnson
    Divisions of General Surgery Molecular Biology and Human Genetics, Faculty of Health Sciences, University of Stellenbosch, P O Box 19063, Tygerberg 7505, South Africa
    Biochem J 411:507-14. 2008
    ..Mouse AChE was observed on docking to bind to a discontinuous, largely basic, structure, Val(2718)-Arg-Lys-Arg-Leu(2722), Tyr(2738)-Tyr(2739), Tyr(2789)-Ile-Lys-Arg-Lys(2793) and Val(2817)-Glu-Arg-Lys(2820), on the ..
  97. pmc Time-dependent alterations in serum NO concentration after oral administration of L-arginine, L-NAME, and allopurinol in intestinal ischemia/reperfusion
    Amalia E Yanni
    Department of Science of Dietetics and Nutrition, Harokopio University of Athens, Athens, Greece
    Vasc Health Risk Manag 4:437-41. 2008
    To study the effect of oral administration of a nitric oxide (NO) donor L-arginine (L-Arg), a NO synthase inhibitor NG-nitro-L-arginine methyl ester (L-NAME) and an inhibitor of xanthine oxidase, allopurinol (Allo), on serum NO ..
  98. ncbi Effect of chronic renal failure on arginase and argininosuccinate synthetase expression
    Hamid Moradi
    Division of Nephrology and Hypertension, University of California, Irvine, CA 92868, USA
    Am J Nephrol 26:310-8. 2006
    L-arginine (L-arg) participates in numerous biological functions including urea and nitric oxide synthesis. Sources of L-arg include dietary proteins and endogenous synthesis by argininosuccinate synthetase and argininosuccinate lyase...
  99. ncbi Binding of the arginine repressor of Escherichia coli K12 to its operator sites
    G Tian
    Department of Microbiology, New York University Medical Center, NY 10016
    J Mol Biol 226:387-97. 1992
    ..coli K12 each of the eight operator sites consists of two 18-base-pair-long palindromic sequences called ARG boxes...
  100. ncbi Identification of arginyl residues located at the ATP binding site of sarcoplasmic reticulum Ca2+-ATPase. Modification with 1,2-cyclohexanedione
    K Kimura
    Department of Biochemistry, Asahikawa Medical College, Asahikawa 078, Japan
    J Biol Chem 271:28933-41. 1996
    ..of peptides containing CHD-modified arginyl residues with Girard's reagent T, and sequencing revealed that Arg-489, Arg-505, and Arg-678 were modified with CHD. Arg-489 and Arg-678 were almost completely protected by Mg...
  101. ncbi Hydrolysis by somatic angiotensin-I converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with gly-Arg/Lys-arg, but not from diarginyl insulin
    R E Isaac
    School of Biology, University of Leeds, UK
    Eur J Biochem 262:569-74. 1999
    Endoproteolytic cleavage of protein prohormones often generates intermediates extended at the C-terminus by Arg-Arg or Lys-Arg, the removal of which by a carboxypeptidase (CPE) is normally an important step in the maturation of many ..

Research Grants90

  1. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith T Wilson; Fiscal Year: 2010
    ..The semi-essential amino acid L-arginine (L-Arg) has been touted as a supplement with many potential benefits including enhancement of immunity...
  2. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith Wilson; Fiscal Year: 2009
    ..The semi-essential amino acid L-arginine (L-Arg) has been touted as a supplement with many potential benefits including enhancement of immunity...
  3. L-arginine metabolism in diabetes-induced coronary dysfunction
    Robert William Caldwell; Fiscal Year: 2010
    ..which are associated with reactive oxygen species (ROS) formation and increased arginase activity, which diverts L-arg from eNOS to the ornithine pathway...
  4. Immunomodulatory effects of arginine supplementation in colitis and colon cancer
    Keith Wilson; Fiscal Year: 2009
    In the Parent R01, we are studying L-arginine (L-Arg) in vitro and in vivo in mouse models of colitis. Since the start of this grant on 9/15/08, we have made substantial progress...
  5. Protein Arginine Methylation in Trypanosomes
    Laurie K Read; Fiscal Year: 2010
    Protein arginine (arg) methylation is a common posttranslational modification of RNA binding proteins (RNA BPs) in yeast and mammals...
  6. Human engineered enzymes for L-Arg depletion chemotherapy
    GEORGE GEORGIOU GEORGIOU; Fiscal Year: 2010
    ..We believe that the research outlined here can create safe, effective, therapeutic agents for patients with hepatocellular carcinomas, and give our afflicted loved ones a second chance at life. ..
  7. Endothelial Cell Dysfunction in Oxidative Stress Models
    Robert Caldwell; Fiscal Year: 2005
    ..Evidence suggests that supplemental L-arginine (L-arg) is therapeutically useful in reversing endothelial dysfunction and treating cardiovascular disease, but the ..
  8. STRUCTURAL METALLOBIOCHEMISTRY OF NITRIC OXIDE SYNTHASES
    ELIZABETH GETZOFF; Fiscal Year: 2000
    ..mechanism: first, a monooxygenase-like reaction converts L-arginine to the intermediate N4-hydroxy-L- arginine (NOH-arg), then an unprecedented reaction converts NOH-arg to citrulline and NO...
  9. Arginine Uptake Mechanisms Regulate Nitric Oxide in the Renal Vasculature
    David L Mattson; Fiscal Year: 2010
    ..Previous work from our laboratory demonstrated the importance of L-Arginine (L-Arg) uptake mechanisms in renal epithelial cells...
  10. Arginine Uptake Mechanisms Regulate Nitric Oxide in the Renal Vasculature
    David Mattson; Fiscal Year: 2007
    ..Previous work from our laboratory demonstrated the importance of L-Arginine (L-Arg) uptake mechanisms in renal epithelial cells...
  11. ARGININE THERAPY IN SICKLE CELL DISEASE
    CLAUDIA MORRIS; Fiscal Year: 2004
    ..L- Arginine (L-Arg) is the precursor to NO, and Dr...
  12. Resolution of Epithelial Cell Hyperplasia
    Yohannes Tesfaigzi; Fiscal Year: 2010
    ..A polymorphism in the p53 gene at codon 72 (Arg/Pro) differentially affects Bcl-2 expression;p53Pro increases more efficiently than p53Arg, the pro-apoptotic ..
  13. Resolution of Epithelial Cell Hyperplasia
    Yohannes Tesfaigzi; Fiscal Year: 2009
    ..A polymorphism in the p53 gene at codon 72 (Arg/Pro) differentially affects Bcl-2 expression; p53Pro increases more efficiently than p53Arg, the pro-apoptotic ..
  14. Cross-talk Between Coagulation, Inflammation, and Immunity
    Lawrence L Leung; Fiscal Year: 2010
    ..vivo;the targets for CPB include bradykinin, C5a, the generation of plasmin and thrombin-cleaved osteopontin (OPN-Arg or OPN-R)...
  15. Regulation of invadopodia formation in breast cancer cells
    Anthony J Koleske; Fiscal Year: 2010
    ..We have shown that adhesion to ECM activates integrin adhesion receptors to stimulate the Arg tyrosine kinase. In turn, Arg phosphorylates cortactin to promote dynamic invadopodia-like cell edge protrusions...
  16. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2009
    ..These findings indicate that Arg/Lys aminopeptidase is then necessary to remove such basic residues...
  17. BIOSYNTHESIS OF ENKEPHALIN OPIOID PEPTIDES
    Vivian Hook; Fiscal Year: 2007
    ..These findings indicate that Arg/Lys aminopeptidase is then necessary to remove such basic residues...
  18. Role of Myelin in Spinal Cord Regeneration
    Marie Filbin; Fiscal Year: 2007
    ..is transcription-dependent and one protein that is up regulated in response to cAMP is the enzyme Arginase I (Arg I), which is key in the synthesis of polyamines...
  19. POMC Processing and Beta-Endorphin-Related Opioid Peptides
    Vivian Hook; Fiscal Year: 2007
    ..L for dibasic processing sites generates peptide intermediates with NH2-terminal basic residues, indicating that Arg/Lys aminopeptidase is then necessary to remove such basic residues...
  20. POMC Processing and Beta-Endorphine-Related Opioid Peptides
    Vivian Y H Hook; Fiscal Year: 2010
    ..L for dibasic processing sites generates peptide intermediates with NH2-terminal basic residues, indicating that Arg/Lys aminopeptidase is then necessary to remove such basic residues...
  21. Structure and Function of Carboxypeptidases
    Randal A Skidgel; Fiscal Year: 2010
    ..carboxypeptidase (CP) M is an important regulator of the kallikrein- kinin system via its ability to generate des-Arg-kinin agonists of the G-protein coupled kinin B1 receptor (B1R)...
  22. MECHANISMS OF PROCESSES OF THE TEM-1 BETA-LACTAMASE
    Shahriar Mobashery; Fiscal Year: 1993
    ..for active site anchoring of substrates involving hydrogen bonding by the side chains of Ser-130, Ser-235, and Arg-244 to the substrate carboxylate is presented...
  23. Excessive Receptor Editing and Generation of Autoreactive Antibodies in SLE
    Zhixin Zhang; Fiscal Year: 2010
    ..naove B cells revealed many features of autoantibodies, such as long CDR3 regions with multiple positively charged Arg residues...
  24. MECHANISM OF SITE SPECIFIC DNA RECOMBINATION
    Makkuni Jayaram; Fiscal Year: 2001
    ..The Arg-His-Arg (RHR) triad appears to form part of the catalytic pocket as well...
  25. Excessive Receptor Editing and Generation of Autoreactive Antibodies in SLE
    Zhixin Zhang; Fiscal Year: 2009
    ..naove B cells revealed many features of autoantibodies, such as long CDR3 regions with multiple positively charged Arg residues...
  26. Mechanisms of a Novel Chemotactic Cofactor for C5a
    Richard R Kew; Fiscal Year: 2010
    Activation of complement (C) with consequent generation of the C5-derived peptides C5a and C5a des Arg is a primary chemotactic stimulus at sites of infection or injury...
  27. Mechanisms of a Novel Chemotactic Cofactor for C5a
    Richard R Kew; Fiscal Year: 2010
    Activation of complement (C) with consequent generation of the C5-derived peptides C5a and C5a des Arg is a primary chemotactic stimulus at sites of infection or injury...
  28. CONTROL OF ARG-2 GENE EXPRESSION IN NEUROSPORA
    MATTHEW SACHS; Fiscal Year: 2007
    ..attenuator peptide (AAP) is encoded by a uORF in the 5'-leader regions of mRNAs specifying a fungal arginine (Arg) biosynthetic enzyme; it reduces gene expression in response to Arg...
  29. CONTROL OF ARG-2 GENE EXPRESSION IN NEUROSPORA
    MATTHEW SACHS; Fiscal Year: 2007
    ..attenuator peptide (AAP) is encoded by a uORF in the 5'-leader regions of mRNAs specifying a fungal arginine (Arg) biosynthetic enzyme; it reduces gene expression in response to Arg...
  30. CONTROL OF ARG-2 GENE EXPRESSION IN NEUROSPORA
    MATTHEW SACHS; Fiscal Year: 2009
    ..attenuator peptide (AAP) is encoded by a uORF in the 5'-leader regions of mRNAs specifying a fungal arginine (Arg) biosynthetic enzyme; it reduces gene expression in response to Arg...
  31. CONTROL OF ARG-2 GENE EXPRESSION IN NEUROSPORA
    MATTHEW SACHS; Fiscal Year: 2006
    ..attenuator peptide (AAP) is encoded by a uORF in the 5'-leader regions of mRNAs specifying a fungal arginine (Arg) biosynthetic enzyme; it reduces gene expression in response to Arg...
  32. Mechanisms of a Novel Chemotactic Cofactor for C5a
    RICHARD KEW; Fiscal Year: 2005
    ..Complement pro-inflammatory peptides C5a and C5a des Arg also have been implicated in disease pathogenesis...
  33. A New Pathway for Neutrophil-induced Airway Inflammation
    J Edwin Blalock; Fiscal Year: 2010
    ..We have developed a potent antagonist, Arg-Thr-Arg, termed RTR, which binds PGP in solution and blocks its in vitro chemotactic activity and in vivo ..
  34. Molecular mechanisms in the regulation of p53 functions by PAD4
    Yanming Wang; Fiscal Year: 2009
    ..g., histone acetyltransferases and protein Arg methyltransferases) and corepressors (e.g...
  35. Molecular mechanisms in the regulation of p53 functions by PAD4
    Yanming Wang; Fiscal Year: 2010
    ..g., histone acetyltransferases and protein Arg methyltransferases) and corepressors (e.g...
  36. STRUCTURE AND FUNCTION OF HEPARIN COFACTOR II
    DOUGLAS TOLLEFSEN; Fiscal Year: 2000
    ..1) investigating the mechanism by which heparin facilitates dissociation between thrombin the HCII mutant Leu444 Arg; 2) to determine the affects of synthetic reactive site peptides on the ability of heparin cofactor 2 to serve as ..