ABL2

Summary

Gene Symbol: ABL2
Description: ABL proto-oncogene 2, non-receptor tyrosine kinase
Alias: ABLL, ARG, tyrosine-protein kinase ABL2, Abelson tyrosine-protein kinase 2, abelson-related gene protein, c-abl oncogene 2, non-receptor tyrosine kinase, tyrosine-protein kinase ARG, v-abl Abelson murine leukemia viral oncogene homolog 2
Species: human
Products:     ABL2

Top Publications

  1. Chen W, Kung H, Yang W, Lin W. Comparative tyrosine-kinase profiles in colorectal cancers: enhanced arg expression in carcinoma as compared with adenoma and normal mucosa. Int J Cancer. 1999;83:579-84 pubmed
    ..kinases expressed in these tissues: they include 10 non-receptor tyrosine kinases (yes, fyn, lyn, brk, abl, arg, jak1, jak3, tyk2 and itk), 17 receptor tyrosine kinases (erbB2, PDGF-Ralpha, PDGF-Rbeta, kit, c-fms, met, ron, FGF-..
  2. Tanis K, Veach D, Duewel H, Bornmann W, Koleske A. Two distinct phosphorylation pathways have additive effects on Abl family kinase activation. Mol Cell Biol. 2003;23:3884-96 pubmed
    The activities of the related Abl and Arg nonreceptor tyrosine kinases are kept under tight control in cells, but exposure to several different stimuli results in a two- to fivefold stimulation of kinase activity...
  3. Srinivasan D, Kaetzel D, Plattner R. Reciprocal regulation of Abl and receptor tyrosine kinases. Cell Signal. 2009;21:1143-50 pubmed publisher
    Previously, we showed that Abl kinases (c-Abl, Arg) are activated downstream of PDGF in a manner dependent on Src kinases and PLC-gamma1, and promote PDGF-mediated proliferation and migration of fibroblasts...
  4. Cazzaniga G, Tosi S, Aloisi A, Giudici G, Daniotti M, Pioltelli P, et al. The tyrosine kinase abl-related gene ARG is fused to ETV6 in an AML-M4Eo patient with a t(1;12)(q25;p13): molecular cloning of both reciprocal transcripts. Blood. 1999;94:4370-3 pubmed
    ..reaction (3'RACE-PCR), a novel fusion transcript was identified between the ETV6 and the Abelson-related gene (ARG) at 1q25, resulting in a chimeric protein consisting of the HLH oligomerization domain of ETV6 and the SH2, SH3, ..
  5. Iijima Y, Ito T, Oikawa T, Eguchi M, Eguchi Ishimae M, Kamada N, et al. A new ETV6/TEL partner gene, ARG (ABL-related gene or ABL2), identified in an AML-M3 cell line with a t(1;12)(q25;p13) translocation. Blood. 2000;95:2126-31 pubmed
    ..We identified a novel ETV6 partner gene, ARG (ABL-related gene or ABL2), another TK gene in a cell line established from a patient with acute myelogenous leukemia (AML-M3) with a t(15;17)..
  6. Pendergast A. The Abl family kinases: mechanisms of regulation and signaling. Adv Cancer Res. 2002;85:51-100 pubmed
  7. Mader C, Oser M, Magalhaes M, Bravo Cordero J, Condeelis J, Koleske A, et al. An EGFR-Src-Arg-cortactin pathway mediates functional maturation of invadopodia and breast cancer cell invasion. Cancer Res. 2011;71:1730-41 pubmed publisher
    ..In this study, we provide evidence that the Abl-related nonreceptor tyrosine kinase Arg mediates epidermal growth factor (EGF)-induced cortactin phosphorylation, triggering actin polymerization in ..
  8. Ma Q, Wang J, Liu X, Yang Y, Zhao H, Wang Y, et al. c-Abl and Arg tyrosine kinases regulate lysosomal degradation of the oncoprotein Galectin-3. Cell Death Differ. 2010;17:1277-87 pubmed publisher
    ..This study shows that c-Abl and Abl-related gene (Arg) associate with and phosphorylate Gal3...
  9. Ganguly S, Fiore L, Sims J, Friend J, Srinivasan D, Thacker M, et al. c-Abl and Arg are activated in human primary melanomas, promote melanoma cell invasion via distinct pathways, and drive metastatic progression. Oncogene. 2012;31:1804-16 pubmed publisher
    ..Here, we found a previously unrecognized role for c-Abl and Arg in melanoma progression...

More Information

Publications140 found, 100 shown here

  1. Meier L, Auger J, Engelson B, Cowan H, Breed E, Gonzalez Torres M, et al. CD301b/MGL2+ Mononuclear Phagocytes Orchestrate Autoimmune Cardiac Valve Inflammation and Fibrosis. Circulation. 2018;137:2478-2493 pubmed publisher
    ..g7 mice and are also present in human rheumatic heart disease. We define key inflammatory molecules that drive MVD in this model, including Syk, TNF, interleukin-6, very late antigen-4, and vascular cell adhesion molecule-1. ..
  2. Bhattacharya P, Dey R, Dagur P, Kruhlak M, Ismail N, Debrabant A, et al. Genetically Modified Live Attenuated Leishmania donovani Parasites Induce Innate Immunity through Classical Activation of Macrophages That Direct the Th1 Response in Mice. Infect Immun. 2015;83:3800-15 pubmed publisher
    ..e., the IL-10, YM1, Arg-1, and MRC-1 genes, compared to WT L. donovani-infected mice...
  3. Filiz E, Vatansever R, Ozyigit I. Molecular docking of Glycine max and Medicago truncatula ureases with urea; bioinformatics approaches. Mol Biol Rep. 2016;43:129-40 pubmed publisher
    ..Besides, Ala and Arg residues, which are reported in active-site architecture of plant and bacterial ureases were present in G...
  4. Liao C, Lin Y, Kuo C. Effect of high-fat diet on hepatic proteomics of hamsters. J Agric Food Chem. 2015;63:1869-81 pubmed publisher
    ..ornithine transcarbamoylase (OTC), argininosuccinate synthase (ASS), argininosuccinate lyase (ASL), and arginase 1 (ARG 1). Post-translational modifications (PTM) of ANXA3, ANXA5, and XDH were also analyzed...
  5. Ramakrishnan A, Vijayakumar N. Urea cycle pathway targeted therapeutic action of naringin against ammonium chloride induced hyperammonemic rats. Biomed Pharmacother. 2017;94:1028-1037 pubmed publisher
    ..ornithine transcarbamylase (OTC), arininosuccinate synthase (ASS), argininosuccinate lyase (ASL) and arginase I (ARG) and metabotropic glutamate receptors (mGluRs) such as mGluRs I and mGluRs V and down regulate the expression of ..
  6. Ng C, Tay M, Tan B, Le T, Haller L, Chen H, et al. Characterization of Metagenomes in Urban Aquatic Compartments Reveals High Prevalence of Clinically Relevant Antibiotic Resistance Genes in Wastewaters. Front Microbiol. 2017;8:2200 pubmed publisher
    ..and municipal wastewater (n = 6) were found to have higher diversity and average abundance of ARGs (303 ARG subtypes, 197,816 x/Gb) compared to treated wastewater effluent (n = 2, 58 ARG subtypes, 2,692 x/Gb) and ..
  7. Mishra S, Mishra R. Tolerance of hyperammonemia in brain of Heteropneustes fossilis is supported by glutamate-glutamine cycle. J Chem Neuroanat. 2017;80:11-18 pubmed publisher
    ..expression of mRNA of lactate dehydrogenase (Ldh), super oxide dismutase (Sod), catalase (Catalase), arginase-I (Arg I), inducible nitric oxide (iNos), glutaminase (GA), and brain derived neurotrophic factor (Bdnf) was up-regulated ..
  8. Na J, Jung J, Bang J, Lu Q, Carlson B, Guo X, et al. Selenophosphate synthetase 1 and its role in redox homeostasis, defense and proliferation. Free Radic Biol Med. 2018;127:190-197 pubmed publisher
    ..However, in eukaryotes, SEPHS1 contains other amino acids such as Thr, Arg, Gly, or Leu at the catalytic domain, and SEPHS2 contains only a Sec...
  9. Dong X, Zhou Z, Wang L, Saremi B, Helmbrecht A, Wang Z, et al. Increasing the availability of threonine, isoleucine, valine, and leucine relative to lysine while maintaining an ideal ratio of lysine:methionine alters mammary cellular metabolites, mammalian target of rapamycin signaling, and gene transcription. J Dairy Sci. 2018;101:5502-5514 pubmed publisher
    ..9:1 Lys:Met; 1.8:1 Lys:Thr; 2.38:1 Lys:His; 1.23:1 Lys:Val; 1.45:1 Lys:Ile; 0.85:1 Lys:Leu; 2.08:1 Lys:Arg) or IPAA supplemented with Thr, Ile, Val, and Leu to achieve a Lys:Thr 1.3:1 (LT1.3), Lys:Ile 1.29:1 (LI1...
  10. Noundou X, Krause R, van Vuuren S, Ndinteh D, Olivier D. Antibacterial effects of Alchornea cordifolia (Schumach. and Thonn.) Müll. Arg extracts and compounds on gastrointestinal, skin, respiratory and urinary tract pathogens. J Ethnopharmacol. 2016;179:76-82 pubmed publisher
    The leaves, stems and roots of Alchornea cordifolia (Schumach. and Thonn.) Müll. Arg. are used as traditional medicine in many African countries for the management of gastrointestinal, respiratory and urinary tract infections as well ..
  11. Kumar A, Thotakura P, Tiwary B, Krishna R. Target identification in Fusobacterium nucleatum by subtractive genomics approach and enrichment analysis of host-pathogen protein-protein interactions. BMC Microbiol. 2016;16:84 pubmed publisher
    ..Database of Essential Genes (DEG), Virulence Factor Database (VFDB) and Antibiotic Resistance Gene-ANNOTation (ARG-ANNOT) tool respectively...
  12. Mukungu N, Abuga K, Okalebo F, Ingwela R, Mwangi J. Medicinal plants used for management of malaria among the Luhya community of Kakamega East sub-County, Kenya. J Ethnopharmacol. 2016;194:98-107 pubmed publisher
    ..P.G.Waterman and Leucas calostachys Oliv. Rumex steudelii Hochst.ex A. Rich and Phyllanthus sepialis Müll. Arg are reported for the first time in the management of malaria. Although Clerodendrum johnstonii Oliv. (Jeruto et al...
  13. Matamoros M, Kim A, Peñuelas M, Ihling C, Griesser E, Hoffmann R, et al. Protein Carbonylation and Glycation in Legume Nodules. Plant Physiol. 2018;177:1510-1528 pubmed publisher
  14. Hong K, Yu Z, Sun X, Wu C, Weng P, Wei M, et al. [Effect of caveolin-1 scaffolding domain peptides on heme oxygenase-1 activity increasing and M1/M2 phenotype polarization in rat alveolar macrophages induced by lipopolysaccharide]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2018;30:855-860 pubmed publisher
    ..and there was no significant difference in the binding ability between the two peptides, but the deletion of 101 Arg resulted in the disappearance of part of the binding region between Δ101CSD and HO-1...
  15. Walrant A, Cardon S, Burlina F, Sagan S. Membrane Crossing and Membranotropic Activity of Cell-Penetrating Peptides: Dangerous Liaisons?. Acc Chem Res. 2017;: pubmed publisher
    ..We show a particular role of Trp (indole side chain) and Arg (guanidinium side chain), which are essential amino acids for CPP internalization...
  16. Singh K, Al Greene N, Verriere T, Coburn L, Asim M, Barry D, et al. The L-Arginine Transporter Solute Carrier Family 7 Member 2 Mediates the Immunopathogenesis of Attaching and Effacing Bacteria. PLoS Pathog. 2016;12:e1005984 pubmed publisher
    Solute carrier family 7 member 2 (SLC7A2) is an inducible transporter of the semi-essential amino acid L-arginine (L-Arg), which has been implicated in immune responses to pathogens...
  17. Yang W, Sharma A, Zhang F, Matsuo S, Wang Z, Wang H, et al. Milk fat globule epidermal growth factor-factor 8-derived peptide attenuates organ injury and improves survival in sepsis. Crit Care. 2015;19:375 pubmed publisher
    ..MFG-E8 contains an Arg-Gly-Asp (RGD) motif involved in cell-cell and cell-matrix interactions...
  18. Mishra R, Tseng T, Chen M, Chen P, Lee T. Bacterial toxins activation of abbreviated urea cycle in porcine cerebral vascular smooth muscle cells. Vascul Pharmacol. 2016;87:110-120 pubmed publisher
    ..to form argininosuccinate (AS), and subsequent AS cleavage by argininosuccinate lyase (ASL) forms l-arginine (l-arg), the substrate for NO synthesis...
  19. Harmon E, Fronhofer V, Keller R, Feustel P, Zhu X, Xu H, et al. Anti-inflammatory immune skewing is atheroprotective: Apoe−/−FcγRIIb−/− mice develop fibrous carotid plaques. J Am Heart Assoc. 2014;3:e001232 pubmed publisher
    ..Plaques from DKO animals expressed higher arginase 1 (Arg‐1) and lower inducible nitric oxide synthase (iNOS), indicating the presence of M2 macrophages...
  20. Akhtar F, Rouse C, Catano G, Montalvo M, Ullevig S, Asmis R, et al. Acute maternal oxidant exposure causes susceptibility of the fetal brain to inflammation and oxidative stress. J Neuroinflammation. 2017;14:195 pubmed publisher
    ..and the enhanced expression of M2-like microglial phenotype markers (IL-10, IL-4, TGF-?, CXCL10, CCL22, Chi, Arg, and CCR2)...
  21. Li Y, Zhang C, Sheng Q, Bai H, Ding Y, Dou X. Mesenchymal stem cells rescue acute hepatic failure by polarizing M2 macrophages. World J Gastroenterol. 2017;23:7978-7988 pubmed publisher
    ..IFN-?), inducible nitric oxide synthase (INOS)] and M2 markers [CD163, interleukin (IL)-4, IL-10, arginase-1 (Arg-1)] in the survival and death groups after MSC transplantation...
  22. Jia W, Wang J, Xu H, Li G. Resistance of Stenotrophomonas maltophilia to Fluoroquinolones: Prevalence in a University Hospital and Possible Mechanisms. Int J Environ Res Public Health. 2015;12:5177-95 pubmed publisher
    ..4% of total isolates. Glu-Lys mutation (GAA-AAA) was detected at the 151th amino acid of the gyrA gene, while Gly-Arg mutation (GGC-CGC) was found at the 37th amino acid of the parC gene...
  23. Hu Z, Pei G, Wang P, Yang J, Zhu F, Guo Y, et al. Biliverdin Reductase A (BVRA) Mediates Macrophage Expression of Interleukin-10 in Injured Kidney. Int J Mol Sci. 2015;16:22621-35 pubmed publisher
    ..in macrophages infected with recombinant adenoviruses BVRA gene, which BVRA over-expressed enhanced both INOS and ARG-1 mRNA expression, resulting in a specific macrophage phenotype...
  24. Gupta V, Kaushik A, Chauhan D, Ahirwar R, Sharma S, Bisht D. Anti-mycobacterial activity of some medicinal plants used traditionally by tribes from Madhya Pradesh, India for treating tuberculosis related symptoms. J Ethnopharmacol. 2018;227:113-120 pubmed publisher
    ..Br., Glycyrrhiza glabra L., Holorrhena antidysentrica (Roth) Wall. exA.DC., Mallotus philippensis (Lam.) Müll. Arg., Eulophia nuda Lindl., Cocculus hirsutus (L.) Diels, Pueraria tuberosa (Willd.) DC., Cyperus rotundus L...
  25. Mishra B, Lushnikova T, Golla R, Wang X, Wang G. Design and surface immobilization of short anti-biofilm peptides. Acta Biomater. 2017;49:316-328 pubmed publisher
    ..that the high potency of the tryptophan-rich short peptide is coupled with arginines, whereas these Trp- and Arg-rich peptides are less toxic to select human cells than the lysine-containing analogs...
  26. Wang P, Xu L, Qin J, Zhang L, Zhuang G. MicroRNA-155 inversely correlates with esophageal cancer progression through regulating tumor-associated macrophage FGF2 expression. Biochem Biophys Res Commun. 2018;503:452-458 pubmed publisher
    ..TNF-?), interleukin (IL)-12 and inducible nitric oxide synthase (iNOS), while down-regulated IL-10, Arginase-1 (Arg-1) and IL-22 levels in the culture medium from TAMs...
  27. Lu M, Zhang L, Sartippour M, Norris A, Brooks M. EG-1 interacts with c-Src and activates its signaling pathway. Int J Oncol. 2006;29:1013-8 pubmed
    ..Furthermore, EG-1 shows interaction with multiple other SH3- and WW-containing molecules involved in various signaling pathways. These observations suggest that EG-1 may be involved in signaling pathways including c-Src activation. ..
  28. Święch D, Tanabe I, Vantasin S, Sobolewski D, Ozaki Y, Prahl A, et al. Tip-enhanced Raman spectroscopy of bradykinin and its B2 receptor antagonists adsorbed onto colloidal suspended Ag nanowires. Phys Chem Chem Phys. 2015;17:22882-92 pubmed publisher
    The tip-enhanced Raman scattering (TERS) spectra of bradykinin (BK) and its potent B2 BK receptor antagonists, [d-Arg(0),Hyp(3),Thi(5,8),l-Pip(7)]BK and [d-Arg(0),Hyp(3),Thi(5),d-Phe(7),l-Pip(8)]BK, approximately with a size of about 40 ..
  29. Ebhardt H. Applying Arginylation for Bottom-Up Proteomics. Methods Mol Biol. 2015;1337:129-38 pubmed publisher
    ..3.2.8) conjugates a single arginyl moiety from aminoacylated tRNA(Arg) onto a target polypeptide...
  30. Rochell S, Parsons C, Dilger R. Effects of Eimeria acervulina infection severity on growth performance, apparent ileal amino acid digestibility, and plasma concentrations of amino acids, carotenoids, and α1-acid glycoprotein in broilers. Poult Sci. 2016;95:1573-81 pubmed publisher
    ..05) in plasma carotenoid concentrations. Plasma concentrations of Arg and Tyr decreased linearly (P < 0.05) with increasing E...
  31. Jin Z, Furukawa T, Degardin M, Sugyo A, Tsuji A, Yamasaki T, et al. ?V?3 Integrin-Targeted Radionuclide Therapy with 64Cu-cyclam-RAFT-c(-RGDfK-)4. Mol Cancer Ther. 2016;15:2076-85 pubmed publisher
    ..We have developed a tetrameric cyclic RGD (Arg-Gly-Asp) peptide-based radiotracer (64)Cu-cyclam-RAFT-c(-RGDfK-)4, which successfully captured ?V?3-positive tumors ..
  32. Loft M, Sun Y, Liu C, Christensen C, Huang D, Kjaer A, et al. Improved positron emission tomography imaging of glioblastoma cancer using novel 68Ga-labeled peptides targeting the urokinase-type plasminogen activator receptor (uPAR). Amino Acids. 2017;49:1089-1100 pubmed publisher
    ..The uPAR-targeting peptide AE105-NH2 (Ac-Asp-Cha-Phe-(D)Ser-(D)Arg-Tyr-Leu-Trp-Ser-CONH2) is a promising candidate for non-invasive positron emission tomography (PET) ..
  33. Al Temimi A, Boltje T, Zollinger D, Rutjes F, Feiters M. Peptide-Appended Permethylated ?-Cyclodextrins with Hydrophilic and Hydrophobic Spacers. Bioconjug Chem. 2017;28:2160-2166 pubmed publisher
    ..successfully introduced maleimide function was exploited to covalently graft a cysteine-containing peptide (Ac-Tyr-Arg-Cys-Amide) to produce the target conjugates...
  34. Pan M, Chu L. Occurrence of antibiotics and antibiotic resistance genes in soils from wastewater irrigation areas in the Pearl River Delta region, southern China. Sci Total Environ. 2018;624:145-152 pubmed publisher
    ..manure application, irrigation water sources and cropping patterns also affect the antibiotic concentrations and ARG abundances...
  35. Mahadeo K, Cole P. Successful treatment using omacetaxine for a patient with CML and BCR-ABL1 [corrected] 35INS. Blood. 2010;115:3852 pubmed publisher
  36. Jegatheesan P, Beutheu S, Ventura G, Nubret E, Sarfati G, Bergheim I, et al. Citrulline and Nonessential Amino Acids Prevent Fructose-Induced Nonalcoholic Fatty Liver Disease in Rats. J Nutr. 2015;145:2273-9 pubmed publisher
    ..135%), increased plasma triglycerides (TGs; 67%), and altered plasma amino acid concentrations with decreased Arg bioavailability (-27%). This was corrected by both NEAA and Cit supplementation...
  37. Ferro G, Guarino F, Cicatelli A, Rizzo L. ?-lactams resistance gene quantification in an antibiotic resistant Escherichia coli water suspension treated by advanced oxidation with UV/H2O2. J Hazard Mater. 2017;323:426-433 pubmed publisher
    ..blaTEM was selected as target antibiotic resistance gene (ARG) and was quantified by qPCR in the survived colonies and the whole suspension (total DNA)...
  38. Touhami N, Buhl K, Schmidt Heydt M, Geisen R. Arginine acts as an inhibitor of the biosynthesis of several mycotoxins. Int J Food Microbiol. 2016;235:46-52 pubmed publisher
    ..Arginine (Arg) is one of the strong OTA inhibiting amino acids...
  39. Karmakar T, Roy S, Balaram H, Prakash M, Balasubramanian S. Product Release Pathways in Human and Plasmodium falciparum Phosphoribosyltransferase. J Chem Inf Model. 2016;56:1528-38 pubmed publisher
    ..the reaction center is guided by the negatively charged Asp and Glu and a few positively charged residues (Lys and Arg) that line the product release channels...
  40. Xu Q, Yang L, Yang W, Bai Y, Hou P, Zhao J, et al. Volatile organic compounds released from Microcystis flos-aquae under nitrogen sources and their toxic effects on Chlorella vulgaris. Ecotoxicol Environ Saf. 2017;135:191-200 pubmed publisher
    ..25 and 17 compounds, respectively, with NaNO3, NaNO2, NH4Cl, urea, Ser, Lys and Arg as the sole N source...
  41. Guo J, Man Z, Rao Z, Xu M, Yang T, Zhang X, et al. Improvement of the ammonia assimilation for enhancing L-arginine production of Corynebacterium crenatum. J Ind Microbiol Biotechnol. 2017;44:443-451 pubmed publisher
    ..In previous work, we obtained an L-arginine-producing Corynebacterium crenatum SDNN403 (ARG) through screening and mutation breeding...
  42. Gong M, Zhuo X, Ma A. STAT6 Upregulation Promotes M2 Macrophage Polarization to Suppress Atherosclerosis. Med Sci Monit Basic Res. 2017;23:240-249 pubmed
    ..RESULTS Unstable plaques presented significantly increased M1 markers (CD86 and iNOS) and less M2 markers (Arg-1 and TGF-β) than the stable plaques...
  43. Meireles P, Mendes A, Aroeira R, Mounce B, Vignuzzi M, Staines H, et al. Uptake and metabolism of arginine impact Plasmodium development in the liver. Sci Rep. 2017;7:4072 pubmed publisher
    ..Here, we show that L-arginine (Arg) uptake through the host cell's SLC7A2-encoded transporters is essential for the parasite's development and ..
  44. Barón Sola Á, Fernández Del Campo F, Sanz Alférez S. Influence of Glycine and Arginine on Cylindrospermopsin Production and aoa Gene Expression in Aphanizomenon ovalisporum. Toxins (Basel). 2017;9: pubmed publisher
    Arginine (Arg) and glycine (Gly) seem to be the only substrates accepted by the amidinotransferase that catalyze the first step of the synthesis pathway of the cyanotoxin cylindrospermopsin (CYN), leading to guanidinoacetate (GAA)...
  45. Sharmila G, Halami P, Venkateswaran G. Identification and characterization of a calcium dependent bacillopeptidase from Bacillus subtilis CFR5 with novel kunitz trypsin inhibitor degradation activity. Food Res Int. 2018;103:263-272 pubmed publisher
    ..BPC revealed that mutation of Tyr49 with Phe, Tyr64 with Phe, and Pro141 to Arg affects the catalytic activity without affecting the conformation of BPC...
  46. Abassi Y, Vuori K. Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling. EMBO J. 2002;21:4571-82 pubmed
    ..Together, these results indicate that the Y221 site in CrkII regulates Rac membrane translocation upon cell adhesion, which is necessary for activation of downstream Rac signaling pathways. ..
  47. Ananthanarayanan M, Li S, Balasubramaniyan N, Suchy F, Walsh M. Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1. J Biol Chem. 2004;279:54348-57 pubmed
    ..The increased occupation of the BSEP locus by CARM1 also corresponds with the increased deposition of Arg-17 methylation and Lys-9 acetylation of histone H3 within the FXR DNA-binding element of BSEP...
  48. Conceição K, Magalhães P, Campos S, Domingues M, Ramu V, Michalek M, et al. The anti-inflammatory action of the analgesic kyotorphin neuropeptide derivatives: insights of a lipid-mediated mechanism. Amino Acids. 2016;48:307-18 pubmed publisher
    ..Recently, a designed class of efficient analgesic drugs derived from an endogenous neuropeptide, kyotorphin (KTP, Tyr-Arg) combining C-terminal amidation (KTP-NH2) and N-terminal conjugation to ibuprofen (Ib), IbKTP-NH2, was developed...
  49. Gladkikh I, Monastyrnaya M, Zelepuga E, Sintsova O, Tabakmakher V, Gnedenko O, et al. New Kunitz-Type HCRG Polypeptides from the Sea Anemone Heteractis crispa. Mar Drugs. 2015;13:6038-63 pubmed publisher
    ..crispa cDNA. Polypeptides are characterized by positively charged Arg at the N-terminus as well as P1 Lys residue at their canonical binding loop, identical to those of bovine ..
  50. Krasuska U, Ciacka K, Orzechowski S, Fettke J, Bogatek R, Gniazdowska A. Modification of the endogenous NO level influences apple embryos dormancy by alterations of nitrated and biotinylated protein patterns. Planta. 2016;244:877-91 pubmed publisher
    NO donors and Arg remove dormancy of apple embryos and stimulate germination. Compounds lowering NO level (cPTIO, L -NAME, CAN) strengthen dormancy...
  51. Tang D, Zhang G. Ultrasonic-assistant fabrication of cocoon-like Ag/AgFeO2 nanocatalyst with excellent plasmon enhanced visible-light photocatalytic activity. Ultrason Sonochem. 2017;37:208-215 pubmed publisher
    ..Under visible light irradiation, 20mg/L of ARG solution was completely degraded by 0.25g/L of Ag/AgFeO2 photocatalyst with pseudo-first-order rate of 0...
  52. Skottrup P. Structural insights into a high affinity nanobody:antigen complex by homology modelling. J Mol Graph Model. 2017;76:305-312 pubmed publisher
    ..P. gingivalis secrete a cysteine protease termed RgpB, which is specific for Arg-Xaa bonds in substrates...
  53. Volk E, Farley K, Wu Y, Li F, Robey R, Schneider E. Overexpression of wild-type breast cancer resistance protein mediates methotrexate resistance. Cancer Res. 2002;62:5035-40 pubmed
    ..correlated with BCRP expression in all of the cell lines expressing the wild-type transporter, which contains an Arg at position 482. In contrast, little or no cross-resistance was found in the MCF7/AdVp1000 and S1-M1-3...
  54. Heine C, Schmidt R, Geckl K, Schrammel A, Gesslbauer B, Schmidt K, et al. Selective Irreversible Inhibition of Neuronal and Inducible Nitric-oxide Synthase in the Combined Presence of Hydrogen Sulfide and Nitric Oxide. J Biol Chem. 2015;290:24932-44 pubmed publisher
    ..Inhibition of nNOS was not affected by the concentrations of l-arginine (Arg), NADPH, FAD, FMN, tetrahydrobiopterin (BH4), and calmodulin, indicating that H2S does not interfere with substrate ..
  55. Krasuska U, Andrzejczak O, Staszek P, Borucki W, Gniazdowska A. Toxicity of canavanine in tomato (Solanum lycopersicum L.) roots is due to alterations in RNS, ROS and auxin levels. Plant Physiol Biochem. 2016;103:84-95 pubmed publisher
    Canavanine (CAN) is non-proteinogenic aminoacid and a structural analog of arginine (Arg). Naturally, CAN occurs in legumes e.g. jack bean and is considered as a strong allelochemical...
  56. Jiang Y, Liu S, Zhang Y, Li H, He H, Dai J, et al. Magnetic mesoporous nanospheres anchored with LyP-1 as an efficient pancreatic cancer probe. Biomaterials. 2017;115:9-18 pubmed publisher
    ..we firstly demonstrate the high expression of receptor for cyclic nine-amino acid peptide LyP-1 (Cys-Gly-Asn-Lys-Arg-Thr-Arg-Gly-Cys) in both mouse and human pancreatic cancer...
  57. Kononova O, Litvinov R, Blokhin D, Klochkov V, Weisel J, Bennett J, et al. Mechanistic Basis for the Binding of RGD- and AGDV-Peptides to the Platelet Integrin αIIbβ3. Biochemistry. 2017;56:1932-1942 pubmed publisher
    ..However, peptides containing the Arg-Gly-Asp (RGD) sequences located in two places in the fibrinogen Aα chain inhibit soluble fibrinogen binding to Î..
  58. Puth S, Hong S, Park M, Lee H, Lee Y, Jeong K, et al. Mucosal immunization with a flagellin-adjuvanted Hgp44 vaccine enhances protective immune responses in a murine Porphyromonas gingivalis infection model. Hum Vaccin Immunother. 2017;13:2794-2803 pubmed publisher
    ..We used the Hgp44 domain polypeptide of Arg-gingipain A (RgpA) as a mucosal antigen...
  59. Hou T, Liu Y, Guo D, Li B, He H. Collagen Peptides from Crucian Skin Improve Calcium Bioavailability and Structural Characterization by HPLC-ESI-MS/MS. J Agric Food Chem. 2017;65:8847-8854 pubmed publisher
    ..Structural characterization demonstrated that Glu, Lys, and Arg play important roles in binding calcium and promoting calcium uptake...
  60. Vicente J, Mendiondo G, Movahedi M, Peirats Llobet M, Juan Y, Shen Y, et al. The Cys-Arg/N-End Rule Pathway Is a General Sensor of Abiotic Stress in Flowering Plants. Curr Biol. 2017;27:3183-3190.e4 pubmed publisher
    ..In plants, hypoxia (low oxygen, which occurs during flooding) is directly sensed by the Cys-Arg/N-end rule pathway of ubiquitin-mediated proteolysis, through oxygen-dependent degradation of group VII Ethylene ..
  61. Kim W, Kwon Y, Park M, Yun S, Kwon J, Kim H. Identification of specifically activated angiogenic molecules in HMGB-1-induced angiogenesis. BMB Rep. 2017;: pubmed
    ..some VEGFR signaling-related angiogenic factors including EGR1 and, importantly, novel angiogenic factors, such as ABL2, CEACAM1, KIT, and VIPR1, which are reported to independently promote angiogenesis under physiological and ..
  62. Tsuru M, Sata M, Tanaka M, Umeyama H, Kodera Y, Shiwa M, et al. Retrospective Proteomic Analysis of a Novel, Cancer Metastasis-Promoting RGD-Containing Peptide. Transl Oncol. 2017;10:998-1007 pubmed publisher
    ..We detected a novel RGD (Arg-Gly-Asp)-containing peptide derived from the C-terminal portion of fibrinogen in the sera of metastatic patients ..
  63. Flanagan C, Manilall A. Gonadotropin-Releasing Hormone (GnRH) Receptor Structure and GnRH Binding. Front Endocrinol (Lausanne). 2017;8:274 pubmed publisher
    ..Mutations of GnRH receptor residues involved in these interactions, such as Arg3.50(139) of the DRY/S motif or Tyr7...
  64. Li T, Yu B, Liu Z, Li J, Ma M, Wang Y, et al. Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury. Nat Commun. 2018;9:11 pubmed publisher
    ..of the AT1 receptor both orthosterically and allosterically by forming a salt bridge and a disulfide bond with its Arg167 and Cys289 residues, respectively...
  65. Fiore L, Ganguly S, Sledziona J, Cibull M, Wang C, Richards D, et al. c-Abl and Arg induce cathepsin-mediated lysosomal degradation of the NM23-H1 metastasis suppressor in invasive cancer. Oncogene. 2014;33:4508-4520 pubmed publisher
    ..In addition, activation of c-Abl and Arg oncoproteins induces NM23-H1 degradation in invasive cancer cells by increasing cysteine cathepsin transcription ..
  66. Xie Z, Ye P, Zhang Y, Shen X. Effect of high-concentrate diet on amino acid transporter expression and milk quality in Holstein dairy cows. Genet Mol Res. 2015;14:5246-57 pubmed publisher
    ..05), but Arg and Phe were significantly higher (P < 0.05) in the HC group than in the LC group...
  67. Xhabija B, Vacratsis P. Receptor-mediated Endocytosis 8 Utilizes an N-terminal Phosphoinositide-binding Motif to Regulate Endosomal Clathrin Dynamics. J Biol Chem. 2015;290:21676-89 pubmed publisher
    ..RME-8 to associate with PI(3)P and early endosomes is largely abolished when residues Lys(17), Trp(20), Tyr(24), or Arg(26) are mutated resulting in diffuse cytoplasmic localization of RME-8 while maintaining the ability to interact ..
  68. Guo L, Tian S, Chen Y, Mao Y, Cui S, Hu A, et al. CAT-1 as a novel CAM stabilizes endothelial integrity and mediates the protective actions of L-Arg via a NO-independent mechanism. J Mol Cell Cardiol. 2015;87:180-91 pubmed publisher
    ..with cell confluency, in sub-confluent ECs CAT-1 proteins distribute on the entire surface and function as L-Arg transporters, but most of the CAT-1 in the confluent ECs are localized at interendothelial junctions and serve as ..
  69. Nissar S, Sameer A, Rasool R, Chowdri N, Rashid F. Polymorphism of the DNA Repair Gene XRCC1 (Arg194Trp) and its role in Colorectal Cancer in Kashmiri Population: a Case Control Study. Asian Pac J Cancer Prev. 2015;16:6385-90 pubmed
    ..05) with both the heterozygous genotype (Arg/Trp) as well as homozygous variant genotype (Trp/Trp) being moderately associated with the elevated risk for CRC [..
  70. More A, Mishra J, Hankins G, Kumar S. Prenatal Testosterone Exposure Decreases Aldosterone Production but Maintains Normal Plasma Volume and Increases Blood Pressure in Adult Female Rats. Biol Reprod. 2016;95:42 pubmed publisher
    ..levels, plasma aldosterone, angiotensin II and vasopressin levels, and vascular responses to angiotensin II and arg(8)-vasopressin...
  71. McLellan M, Doyle M, Bodnar E, Lopez P, Domalaon R, Roy R, et al. Multiplex Azido-Group Isotopic Capture (MAGIC) Beads: Selective Analysis of Azido Compounds Using a Propargyl-based Cleavable Linker, a Proof of Concept. Rapid Commun Mass Spectrom. 2016;: pubmed publisher
    ..L-arginine (Arg) is placed just before Pra to permit the release of the captured product by tryptic cleavage...
  72. Yokota E, Koyanagi Y, Yamamoto K, Oi Y, Koshikawa N, Kobayashi M. Opioid subtype- and cell-type-dependent regulation of inhibitory synaptic transmission in the rat insular cortex. Neuroscience. 2016;339:478-490 pubmed publisher
    ..DAMGO-induced depression of uIPSCs was blocked by the MOR antagonist, D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2...
  73. Xing J, Lu L, Unsworth L, Major P, Doschak M, Kaipatur N. RANKL release from self-assembling nanofiber hydrogels for inducing osteoclastogenesis in vitro. Acta Biomater. 2017;49:306-315 pubmed publisher
    ..Various concentrations of fluorescently-labelled RANKL protein were added to NF-hydrogels, composed of Acetyl-(Arg-Ala-Asp-Ala)4-CONH2 [(RADA)4] of different concentrations, to investigate the ..
  74. Shu S, Emert Sedlak L, Smithgall T. Cell-based Fluorescence Complementation Reveals a Role for HIV-1 Nef Protein Dimerization in AP-2 Adaptor Recruitment and CD4 Co-receptor Down-regulation. J Biol Chem. 2017;292:2670-2678 pubmed publisher
    ..Mutagenesis of Nef amino acids Arg-134, Glu-174, and Asp-175, which stabilize Nef for AP-2 α-σ2 binding in a recent co-crystal structure, ..
  75. Choudhury M, McCleary R, Kesherwani M, Kini R, Velmurugan D. Comparison of proteomic profiles of the venoms of two of the 'Big Four' snakes of India, the Indian cobra (Naja naja) and the common krait (Bungarus caeruleus), and analyses of their toxins. Toxicon. 2017;135:33-42 pubmed publisher
    ..caeruleus venom. We further analyzed protein coverage (Lys/Arg rich and poor regions as well as potential glycosylation sites) using in-house software...
  76. Li W, Zhang D, Boyce K, Xi B, Zou H, Wu S, et al. The complete mitochondrial DNA of three monozoic tapeworms in the Caryophyllidea: a mitogenomic perspective on the phylogeny of eucestodes. Parasit Vectors. 2017;10:314 pubmed publisher
    ..All rearrangement events between the four arrangement categories took place at the junction of rrnS-tRNA Arg (P1) where NCRs are common. Highly repetitive regions are detected among NCRs of the four cestode species...
  77. Upadhyay S. Binding and thermodynamics of REV peptide-ctDNA interaction. Biopolymers. 2017;108: pubmed publisher
    ..01, as determined for the ?lnK/?ln[Na+ ] parameter, suggesting the participation of only 3-4 Arg out of 11 Arg charge from REV peptide...
  78. Groves A, Johnston C, Misra R, Williams J, Finkelstein J. Effects of IL-4 on pulmonary fibrosis and the accumulation and phenotype of macrophage subpopulations following thoracic irradiation. Int J Radiat Biol. 2016;92:754-765 pubmed
    ..CD206+ cells were evident in fibrotic regions of WT mice only, however Arg-1+ cells increased in fibrotic regions in IL-4-/- mice only...
  79. Martfeld A, Greathouse D, Koeppe R. Ionization Properties of Histidine Residues in the Lipid Bilayer Membrane Environment. J Biol Chem. 2016;291:19146-56 pubmed publisher
    ..The combined results enable us to compare the ionization properties of lipid-exposed His, Lys, and Arg side chains in lipid bilayer membranes.
  80. Dubielecka P, Machida K, Xiong X, Hossain S, Ogiue Ikeda M, Carrera A, et al. Abi1/Hssh3bp1 pY213 links Abl kinase signaling to p85 regulatory subunit of PI-3 kinase in regulation of macropinocytosis in LNCaP cells. FEBS Lett. 2010;584:3279-86 pubmed publisher
  81. Torsello B, Bianchi C, Meregalli C, Di Stefano V, Invernizzi L, De Marco S, et al. Arg tyrosine kinase modulates TGF-?1 production in human renal tubular cells under high-glucose conditions. J Cell Sci. 2016;129:2925-36 pubmed publisher
    ..Our study investigated the involvement of non-receptor tyrosine kinase Arg (also called Abl2) in TGF-? production. Human primary tubular cell cultures exposed to high-glucose conditions were used...
  82. Obayashi E, Luna R, Nagata T, Martin Marcos P, Hiraishi H, Singh C, et al. Molecular Landscape of the Ribosome Pre-initiation Complex during mRNA Scanning: Structural Role for eIF3c and Its Control by eIF5. Cell Rep. 2017;18:2651-2663 pubmed publisher
    ..3c1 contacts eIF1 through Arg-53 and Leu-96, while 3c2 faces 40S protein uS15/S13, to anchor eIF1 to the scanning pre-initiation complex (PIC)...
  83. Wang H, Barbieri C, He J, Gao Y, Shi T, Wu C, et al. Quantification of mutant SPOP proteins in prostate cancer using mass spectrometry-based targeted proteomics. J Transl Med. 2017;15:175 pubmed publisher
    ..Despite inherent limitations due to amino acid sequence constraints, all the PRISM-SRM assays developed using Arg-C digestion showed a linear dynamic range of at least two orders of magnitude, with limits of quantification ranged ..
  84. Li L, Duan C, Zhao Y, Zhang X, Yin H, Wang T, et al. Preventive effects of interleukin-6 in lipopolysaccharide/d-galactosamine induced acute liver injury via regulating inflammatory response in hepatic macrophages. Int Immunopharmacol. 2017;51:99-106 pubmed publisher
    ..and chemokines, TNF-α, RANTES and MCP-1 in macrophages while promoting the expression of M2 markers, such as Arg-1 and Mrc-1 in macrophages...
  85. Gjorevski N, Lutolf M. Synthesis and characterization of well-defined hydrogel matrices and their application to intestinal stem cell and organoid culture. Nat Protoc. 2017;12:2263-2274 pubmed publisher
    ..comprise a poly(ethylene glycol) (PEG) hydrogel backbone functionalized with minimal adhesion cues including RGD (Arg-Gly-Asp), which is sufficient for ISC expansion, and laminin-111, which is required for organoid formation...
  86. Wu D, Huang X, Sun J, Graham D, Xie B. Antibiotic Resistance Genes and Associated Microbial Community Conditions in Aging Landfill Systems. Environ Sci Technol. 2017;51:12859-12867 pubmed publisher
    ..Antibiotics levels were consistently lower in refuse and leachates from older landfills, whereas ARG levels in leachates significantly increased with landfill age (One-way ANOVA, F = 10.8, P < 0.01)...
  87. Ivanova T, Hardes K, Kallis S, Dahms S, Than M, Künzel S, et al. Optimization of Substrate-Analogue Furin Inhibitors. ChemMedChem. 2017;: pubmed publisher
    ..compounds; the highest potency was found for our previously developed inhibitor 4-(guanidinomethyl)phenylacetyl-Arg-Tle-Arg-4-amidinobenzylamide (MI-1148)...
  88. Wang H, Cui J, Zheng Z, Shi Q, Sun T, Liu X, et al. Assembly of RGD-Modified Hydrogel Micromodules into Permeable Three-Dimensional Hollow Microtissues Mimicking in Vivo Tissue Structures. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..hollow micromodules are prepared by photocopolymerizing poly(ethylene glycol) diacrylate (PEGDA) with acryloyl-PEG-Arg-Gly-Asp-Ser (RGDS)...
  89. Naranjo A, Isenring E, Teleni L. Immune-Enhancing Formulas for Patients With Cancer Undergoing Esophagectomy: Systematic Review Protocol. JMIR Res Protoc. 2017;6:e214 pubmed publisher
    ..there is a growing need for clinicians to know whether use of immune-enhancing formulas (IEFs) containing Arg, omega-3, and RNA are a cost-effective approach compared with isonitrogenous-isocaloric formulas to reduce ..
  90. Gardina P, Conway C, Kossman M, Manson M. Aspartate and maltose-binding protein interact with adjacent sites in the Tar chemotactic signal transducer of Escherichia coli. J Bacteriol. 1992;174:1528-36 pubmed
    ..The Arg-64, Arg-69, and Arg-73 residues of Tar have previously been shown to be involved in aspartate sensing...
  91. Uhde I, Toman A, Gross I, Schwanstecher C, Schwanstecher M. Identification of the potassium channel opener site on sulfonylurea receptors. J Biol Chem. 1999;274:28079-82 pubmed
    ..By exchanging domains between SUR1 and SUR2B, we identify two regions (KCO I: Thr(1059)-Leu(1087) and KCO II: Arg(1218)-Asn(1320); rat SUR2 numbering) within the second set of transmembrane domains (TMDII) as critical for KCO ..
  92. Bryan R, Marrelli S, Steenberg M, Schildmeyer L, Johnson T. Effects of luminal shear stress on cerebral arteries and arterioles. Am J Physiol Heart Circ Physiol. 2001;280:H2011-22 pubmed
    ..After removal of the endothelium, the luminal application of a polypeptide containing the Arg-Gly-Asp amino acid sequence (inhibitor of integrin attachment) abolished the flow-induced constriction...