ABCG8

Summary

Gene Symbol: ABCG8
Description: ATP binding cassette subfamily G member 8
Alias: GBD4, STSL, ATP-binding cassette sub-family G member 8, ATP-binding cassette, sub-family G (WHITE), member 8, sterolin 2
Species: human
Products:     ABCG8

Top Publications

  1. Graf G, Li W, Gerard R, Gelissen I, White A, Cohen J, et al. Coexpression of ATP-binding cassette proteins ABCG5 and ABCG8 permits their transport to the apical surface. J Clin Invest. 2002;110:659-69 pubmed
    Mutations in either ATP-binding cassette (ABC) G5 or ABCG8 cause sitosterolemia, an autosomal recessive disorder of sterol trafficking...
  2. Srivastava A, Garg N, Srivastava A, Srivastava K, Mittal B. Effect of genetic variant (rs11887534) in ABCG8 gene in coronary artery disease and response to atorvastatin therapy. Dis Markers. 2010;28:307-13 pubmed publisher
    ATP-binding cassette transporter ABCG8 plays an important role in excretion of cholesterol from liver...
  3. Abellan R, Mansego M, Martinez Hervas S, Martin Escudero J, Carmena R, Real J, et al. Association of selected ABC gene family single nucleotide polymorphisms with postprandial lipoproteins: results from the population-based Hortega study. Atherosclerosis. 2010;211:203-9 pubmed publisher
    ..was to determine the influence of twenty single nucleotide polymorphisms (SNPs) of the ABCA1, ABCG1, ABCG5 and ABCG8 genes on the plasmatic concentrations of total cholesterol (TC), HDL and LDL cholesterol (HDLc, LDLc) in the ..
  4. Chan D, Watts G, Barrett P, Whitfield A, van Bockxmeer F. ATP-binding cassette transporter G8 gene as a determinant of apolipoprotein B-100 kinetics in overweight men. Arterioscler Thromb Vasc Biol. 2004;24:2188-91 pubmed
    ..We examined the influence of genetic variation of the ATP-binding cassette (ABC) transporter G8 on apolipoprotein B (apoB) kinetics in overweight/obese men...
  5. Rudkowska I, Jones P. Polymorphisms in ABCG5/G8 transporters linked to hypercholesterolemia and gallstone disease. Nutr Rev. 2008;66:343-8 pubmed publisher
    ..This review examines links between polymorphisms of ABC G5 (ABCG5) and G8 (ABCG8) transporter genes to hypercholesterolemia and to gallstone disease risk...
  6. Acalovschi M, Ciocan A, Mostean O, Tirziu S, Chiorean E, Keppeler H, et al. Are plasma lipid levels related to ABCG5/ABCG8 polymorphisms? A preliminary study in siblings with gallstones. Eur J Intern Med. 2006;17:490-4 pubmed
    The role of ABCG5 and ABCG8 genes in the determination of plasma lipid levels is currently under intensive investigation...
  7. Junyent M, Tucker K, Smith C, Lane J, Mattei J, Lai C, et al. The effects of ABCG5/G8 polymorphisms on HDL-cholesterol concentrations depend on ABCA1 genetic variants in the Boston Puerto Rican Health Study. Nutr Metab Cardiovasc Dis. 2010;20:558-66 pubmed publisher
  8. Santosa S, Demonty I, Lichtenstein A, Ordovas J, Jones P. Single nucleotide polymorphisms in ABCG5 and ABCG8 are associated with changes in cholesterol metabolism during weight loss. J Lipid Res. 2007;48:2607-13 pubmed
    ..in cholesterol metabolism after weight loss were affected by single nucleotide polymorphisms (SNPs) in ABCG5 and ABCG8 genes. Thirty-five hypercholesterolemic women lost 11.7 +/- 2.5 kg (P < 0.001)...
  9. Szilvasi A, Andrikovics H, Pongrácz E, Kalina A, Komlósi Z, Klein I, et al. Frequencies of four ATP-binding cassette transporter G8 polymorphisms in patients with ischemic vascular diseases. Genet Test Mol Biomarkers. 2010;14:667-72 pubmed publisher
    ATP-binding cassette transporter G8 (ABCG8) was found to participate in plant sterol and cholesterol (CHOL) transport; however, the potential associations of ABCG8 genetic variants and ischemic vascular diseases are largely unknown...

More Information

Publications78

  1. Yu L, Li Hawkins J, Hammer R, Berge K, Horton J, Cohen J, et al. Overexpression of ABCG5 and ABCG8 promotes biliary cholesterol secretion and reduces fractional absorption of dietary cholesterol. J Clin Invest. 2002;110:671-80 pubmed
    Two ATP-binding cassette (ABC) transporters, ABCG5 and ABCG8, have been proposed to limit sterol absorption and to promote biliary sterol excretion in humans...
  2. Kajinami K, Brousseau M, Nartsupha C, Ordovas J, Schaefer E. ATP binding cassette transporter G5 and G8 genotypes and plasma lipoprotein levels before and after treatment with atorvastatin. J Lipid Res. 2004;45:653-6 pubmed
    ..These results suggest that, in patients with hypercholesterolemia, the ABCG8 D19H variant is associated with greater LDLC-lowering response to atorvastatin therapy.
  3. Koeijvoets K, van der Net J, Dallinga Thie G, Steyerberg E, Mensink R, Kastelein J, et al. ABCG8 gene polymorphisms, plasma cholesterol concentrations, and risk of cardiovascular disease in familial hypercholesterolemia. Atherosclerosis. 2009;204:453-8 pubmed publisher
    ..Polymorphisms in the ABCG8 gene have been identified that contribute to the variation in plasma concentrations of plant sterols...
  4. Graf G, Yu L, Li W, Gerard R, Tuma P, Cohen J, et al. ABCG5 and ABCG8 are obligate heterodimers for protein trafficking and biliary cholesterol excretion. J Biol Chem. 2003;278:48275-82 pubmed
    ABCG5 (G5) and ABCG8 (G8) are ATP-binding cassette (ABC) transporters that limit intestinal absorption and promote biliary excretion of neutral sterols...
  5. Caamaño J, Pacheco A, Lanas F, Salazar L. Single nucleotide polymorphisms in ABCG5 and ABCG8 genes in Chilean subjects with polygenic hypercholesterolemia and controls. Clin Chem Lab Med. 2008;46:1581-5 pubmed publisher
    ..excretion of cholesterol from liver and intestine is regulated by ATP-binding cassette half-transporters ABCG5 and ABCG8. Polymorphisms in their genes have been related to higher levels of plasma lipids...
  6. Chen Z, Shin S, Kuo K, Lin K, Yu M, Hsiao P. Significant association of ABCG8:D19H gene polymorphism with hypercholesterolemia and insulin resistance. J Hum Genet. 2008;53:757-63 pubmed publisher
    ..The ATP-binding cassette (ABC) transporters ABCG5 and ABCG8 act as a sterol efflux pump to regulate the absorption of cholesterol and phytosterol...
  7. Zhao H, Houweling A, Vanstone C, Jew S, Trautwein E, Duchateau G, et al. Genetic variation in ABC G5/G8 and NPC1L1 impact cholesterol response to plant sterols in hypercholesterolemic men. Lipids. 2008;43:1155-64 pubmed publisher
    ..low basal plasma PS concentrations consuming spreads with or without 2 g/day of PS. For the ABCG8 1289 C > A (T400 K) polymorphism, the A allele carriers with high basal plasma PS concentrations demonstrated a ..
  8. Stender S, Frikke Schmidt R, Nordestgaard B, Tybjaerg Hansen A. Sterol transporter adenosine triphosphate-binding cassette transporter G8, gallstones, and biliary cancer in 62,000 individuals from the general population. Hepatology. 2011;53:640-8 pubmed publisher
    ..To test the hypothesis that ABCG8 (adenosine triphosphate-binding cassette transporter G8) Asp19His (D19H) genotype predicted risk of gallstones and ..
  9. Remaley A, Bark S, Walts A, Freeman L, Shulenin S, Annilo T, et al. Comparative genome analysis of potential regulatory elements in the ABCG5-ABCG8 gene cluster. Biochem Biophys Res Commun. 2002;295:276-82 pubmed
    The excretion of sterols from the liver and intestine is regulated by the ABCG5 and ABCG8 transporters...
  10. Buch S, Schafmayer C, Volzke H, Becker C, Franke A, von Eller Eberstein H, et al. A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease. Nat Genet. 2007;39:995-9 pubmed
    ..SNPs in 1,105 affected individuals and 873 controls replicated the disease association of SNP A-1791411 in ABCG8 (allelic P value P(CCA) = 4.1 x 10(-9)), which was subsequently attributed to coding variant rs11887534 (D19H)...
  11. Hirata T, Okabe M, Kobayashi A, Ueda K, Matsuo M. Molecular mechanisms of subcellular localization of ABCG5 and ABCG8. Biosci Biotechnol Biochem. 2009;73:619-26 pubmed
    Human ABCG subfamily proteins ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8 are half-type ATP-binding cassette (ABC) proteins that transport sterols or xenobiotics. ABCG1, ABCG2, and ABCG4 function as homodimers on the plasma membrane...
  12. Berge K, Tian H, Graf G, Yu L, Grishin N, Schultz J, et al. Accumulation of dietary cholesterol in sitosterolemia caused by mutations in adjacent ABC transporters. Science. 2000;290:1771-5 pubmed
    ..encode new members of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter family (six mutations in ABCG8 and one in ABCG5) in nine patients with sitosterolemia...
  13. Srivastava A, Srivastava A, Srivastava K, Choudhuri G, Mittal B. Role of ABCG8 D19H (rs11887534) variant in gallstone susceptibility in northern India. J Gastroenterol Hepatol. 2010;25:1758-62 pubmed publisher
    The excretion of cholesterol from the liver is regulated by the ATP-binding cassette transporter ABCG8. A common genetic polymorphism D19H of ABCG8 might be related to the genetic predisposition of gallstone disease, which is causatively ..
  14. Hubacek J, Berge K, Stefkova J, Pitha J, Skodova Z, Lanska V, et al. Polymorphisms in ABCG5 and ABCG8 transporters and plasma cholesterol levels. Physiol Res. 2004;53:395-401 pubmed
    ABCG5 and ABCG8 transporters play an important role in the absorption and excretion of sterols...
  15. Miwa K, Inazu A, Kobayashi J, Higashikata T, Nohara A, Kawashiri M, et al. ATP-binding cassette transporter G8 M429V polymorphism as a novel genetic marker of higher cholesterol absorption in hypercholesterolaemic Japanese subjects. Clin Sci (Lond). 2005;109:183-8 pubmed
    ..Recently, two ABC (ATP-binding cassette) transporters, ABCG5 and ABCG8, have been described as playing an important role in the absorption and excretion of sterols...
  16. Jiang Z, Parini P, Eggertsen G, Davis M, Hu H, Suo G, et al. Increased expression of LXR alpha, ABCG5, ABCG8, and SR-BI in the liver from normolipidemic, nonobese Chinese gallstone patients. J Lipid Res. 2008;49:464-72 pubmed
    ..The mRNA levels of ABCG5, ABCG8, and liver X receptor alpha (LXRalpha) in the gallstone patients were increased by 51, 59, and 102%, respectively, ..
  17. Grunhage F, Acalovschi M, Tirziu S, Walier M, Wienker T, Ciocan A, et al. Increased gallstone risk in humans conferred by common variant of hepatic ATP-binding cassette transporter for cholesterol. Hepatology. 2007;46:793-801 pubmed
    ..In ASPs, gallstones were strongly linked to the D19H variant of the ABCG8 gene (NPL score = 7.1; P = 4.6 x 10(-13))...
  18. Siddapuram S, Mahurkar S, Duvvuru N, Mitnala S, Guduru V, Rebala P, et al. Hepatic cholesterol transporter ABCG8 polymorphisms in gallstone disease in an Indian population. J Gastroenterol Hepatol. 2010;25:1093-8 pubmed publisher
    ..SNP) D19H and T400K in the cholesterol transporter gene ATP-binding cassette, subfamily G, member 8 (ABCG8) in patients with cholesterol gallstones...
  19. Weggemans R, Zock P, Tai E, Ordovas J, Molhuizen H, Katan M. ATP binding cassette G5 C1950G polymorphism may affect blood cholesterol concentrations in humans. Clin Genet. 2002;62:226-9 pubmed
    ATP binding cassette protein G5 (ABCG5) and G8 (ABCG8) may be involved in the regulation of intestinal cholesterol absorption...
  20. Hubacek J, Berge K, Cohen J, Hobbs H. Mutations in ATP-cassette binding proteins G5 (ABCG5) and G8 (ABCG8) causing sitosterolemia. Hum Mutat. 2001;18:359-60 pubmed
    ..in two adjacent genes encoding coordinately regulated ATP binding cassette (ABC) half transporters (ABCG5 and ABCG8). In this paper we describe three novel mutations causing sitosterolemia: 1) a frameshift mutation (c...
  21. Junyent M, Tucker K, Smith C, Garcia Rios A, Mattei J, Lai C, et al. The effects of ABCG5/G8 polymorphisms on plasma HDL cholesterol concentrations depend on smoking habit in the Boston Puerto Rican Health Study. J Lipid Res. 2009;50:565-73 pubmed publisher
    ..002) among smokers. In conclusion, ABCG5/G8 genetic variants modulate HDL-C concentrations, leading to an HDL-C-lowering effect and thereby a potential increased risk for atherosclerosis only in smokers...
  22. Kajinami K, Brousseau M, Ordovas J, Schaefer E. Interactions between common genetic polymorphisms in ABCG5/G8 and CYP7A1 on LDL cholesterol-lowering response to atorvastatin. Atherosclerosis. 2004;175:287-93 pubmed
    ..The ABCG8 H19 allele was significantly associated with a greater LDL cholesterol reduction relative to the wild type D19 ..
  23. Jakulj L, Vissers M, Tanck M, Hutten B, Stellaard F, Kastelein J, et al. ABCG5/G8 polymorphisms and markers of cholesterol metabolism: systematic review and meta-analysis. J Lipid Res. 2010;51:3016-23 pubmed publisher
    ..001) compared with homozygous 19D allele carriers (n = 591). The ABCG8 632V variant was associated with a clinically irrelevant LDL-C reduction, whereas the 19H allele correlated with ..
  24. Viturro E, de Oya M, Lasunción M, Gorgojo L, Moreno J, Benavente M, et al. Cholesterol and saturated fat intake determine the effect of polymorphisms at ABCG5/ABCG8 genes on lipid levels in children. Genet Med. 2006;8:594-9 pubmed
    ..Thus, we analyzed polymorphisms in the ABCG5 and ABCG8 genes, involved in the regulation of intestinal cholesterol absorption, with special interest in a potential ..
  25. Garcia Rios A, Perez Martinez P, Fuentes F, Mata P, Lopez Miranda J, Alonso R, et al. Genetic variations at ABCG5/G8 genes modulate plasma lipids concentrations in patients with familial hypercholesterolemia. Atherosclerosis. 2010;210:486-92 pubmed publisher
    ..nucleotide polymorphisms (SNPs) at ABCG5 (i7892A>G, i18429C>T, Gln604GluC>G, i11836G>A) and five at ABCG8 (5U145T>G, Tyr54CysA>G, Asp19HisG>C, i14222T>C, and Thr400LysG>T) with plasma lipids concentrations ..
  26. Berge K, von Bergmann K, Lutjohann D, Guerra R, Grundy S, Hobbs H, et al. Heritability of plasma noncholesterol sterols and relationship to DNA sequence polymorphism in ABCG5 and ABCG8. J Lipid Res. 2002;43:486-94 pubmed
    ..Two common sequence variations (D19H and T400K) in ABCG8, an ABC half-transporter defective in sitosterolemia, were associated with lower concentrations of plant sterols ..
  27. Kuo K, Shin S, Chen Z, Yang Y, Yang J, Hsiao P. Significant association of ABCG5 604Q and ABCG8 D19H polymorphisms with gallstone disease. Br J Surg. 2008;95:1005-11 pubmed publisher
    Adenosine triphosphate-binding cassette (ABC) transporters ABCG5 and ABCG8 are sterol export pumps regulating biliary cholesterol excretion...
  28. Xu H, Cheng J, Andreotti G, Gao Y, Rashid A, Wang B, et al. Cholesterol metabolism gene polymorphisms and the risk of biliary tract cancers and stones: a population-based case-control study in Shanghai, China. Carcinogenesis. 2011;32:58-62 pubmed publisher
    ..We examined the association of five variants in three lipid metabolism-related genes (CETP, ABCG8 and LRPAP1) and biliary tract cancers and stones in a population-based case-control study in Shanghai, China...
  29. Gylling H, Hallikainen M, Pihlajamaki J, Agren J, Laakso M, Rajaratnam R, et al. Polymorphisms in the ABCG5 and ABCG8 genes associate with cholesterol absorption and insulin sensitivity. J Lipid Res. 2004;45:1660-5 pubmed
    The roles of polymorphisms of the sitosterolemia genes ABCG5 and ABCG8 in the regulation of cholesterol metabolism and insulin sensitivity were studied in mildly hypercholesterolemic noncoronary subjects (n = 263, 144 men and 119 women) ..
  30. Lu K, Lee M, Hazard S, Brooks Wilson A, Hidaka H, Kojima H, et al. Two genes that map to the STSL locus cause sitosterolemia: genomic structure and spectrum of mutations involving sterolin-1 and sterolin-2, encoded by ABCG5 and ABCG8, respectively. Am J Hum Genet. 2001;69:278-90 pubmed
    ..Mutational analyses revealed that this highly homologous protein, termed "sterolin-2" and encoded by ABCG8, is mutated in the remaining pedigrees...
  31. Sumi K, Tanaka T, Uchida A, Magoori K, Urashima Y, Ohashi R, et al. Cooperative interaction between hepatocyte nuclear factor 4 alpha and GATA transcription factors regulates ATP-binding cassette sterol transporters ABCG5 and ABCG8. Mol Cell Biol. 2007;27:4248-60 pubmed
    ..excretion of cholesterol from liver and intestine is regulated by ATP-binding cassette half-transporters ABCG5 and ABCG8. The genes for these two proteins are closely linked and divergently transcribed from a common intergenic promoter ..
  32. Wang Y, Jiang Z, Fei J, Xin L, Cai Q, Jiang Z, et al. ATP binding cassette G8 T400K polymorphism may affect the risk of gallstone disease among Chinese males. Clin Chim Acta. 2007;384:80-5 pubmed
    ..a possible association between transporter gene polymorphism and gallstone formation, we examined five common polymorphisms in the ABCG5 (Q604E) and ABCG8 (D19H, Y54C, T400K, A632V) genes in patients with gallstone disease (GS).
  33. Teupser D, Baber R, Ceglarek U, Scholz M, Illig T, Gieger C, et al. Genetic regulation of serum phytosterol levels and risk of coronary artery disease. Circ Cardiovasc Genet. 2010;3:331-9 pubmed publisher
    ..Serum levels are under tight genetic control. We used a genomic approach to study the molecular regulation of serum phytosterol levels and potential links to coronary artery disease (CAD)...
  34. Plat J, Bragt M, Mensink R. Common sequence variations in ABCG8 are related to plant sterol metabolism in healthy volunteers. J Lipid Res. 2005;46:68-75 pubmed
    Polymorphisms in the ATP binding cassette (ABC) transporters ABCG5 and ABCG8 are related to plasma plant sterol concentrations...
  35. Yamazaki Y, Hashizume T, Morioka H, Sadamitsu S, Ikari A, Miwa M, et al. Diet-induced lipid accumulation in liver enhances ATP-binding cassette transporter g5/g8 expression in bile canaliculi. Drug Metab Pharmacokinet. 2011;26:442-50 pubmed
    The ATP-binding cassette half-transporters Abcg5 and Abcg8 promote the secretion of neutral sterols into bile...
  36. Zhong C, Sun W, Ma Y, Zhu H, Yang P, Wei H, et al. Microbiota prevents cholesterol loss from the body by regulating host gene expression in mice. Sci Rep. 2015;5:10512 pubmed publisher
    ..and hepatic cholesterol, and likely caused by reduced expression of NPC1L1 and increased expression of ABCG5 and ABCG8 in small intestine...
  37. Castro Torres I, de Jesús Cárdenas Vázquez R, Velázquez González C, Ventura Martínez R, De la O Arciniega M, Naranjo Rodríguez E, et al. Future therapeutic targets for the treatment and prevention of cholesterol gallstones. Eur J Pharmacol. 2015;765:366-74 pubmed publisher
    ..very complex imbalances, such as alterations in the secretion of biliary lipids (which involves the ABCG5, ABCG8, ABCB4 and ABCB11 transporters), biochemical and immunological reactions in the gallbladder that produce biliary ..
  38. Berge K. Sitosterolemia: a gateway to new knowledge about cholesterol metabolism. Ann Med. 2003;35:502-11 pubmed
    ..ABCG5 or ABCG8. These two genes are expressed almost exclusively in the liver and intestine, and are co-regulated by the nuclear ..
  39. Calpe Berdiel L, Rotllan N, Fievet C, Roig R, Blanco Vaca F, Escola Gil J. Liver X receptor-mediated activation of reverse cholesterol transport from macrophages to feces in vivo requires ABCG5/G8. J Lipid Res. 2008;49:1904-11 pubmed publisher
    ..Our data provide direct in vivo evidence of the crucial role of ABCG5 and ABCG8 in LXR-mediated induction of macrophage-specific RCT.
  40. Li Q, Yin R, Wei X, Yan T, Aung L, Wu D, et al. ATP-binding cassette transporter G5 and G8 polymorphisms and several environmental factors with serum lipid levels. PLoS ONE. 2012;7:e37972 pubmed publisher
    ..The present study was undertaken to detect the association of ABCG5/G8 SNPs and several environmental factors with serum lipid levels...
  41. von Schönfels W, Buch S, Wölk M, Aselmann H, Egberts J, Schreiber S, et al. Recurrence of gallstones after cholecystectomy is associated with ABCG5/8 genotype. J Gastroenterol. 2013;48:391-6 pubmed publisher
    ..As yet, variant ABCG8-D19H is the most widely recognized genetic risk factor for gallstone disease...
  42. Ratliff E, Gutierrez A, Davis R. Transgenic expression of CYP7A1 in LDL receptor-deficient mice blocks diet-induced hypercholesterolemia. J Lipid Res. 2006;47:1513-20 pubmed
    ..Hepatic mRNA expression of liver X receptor-inducible ABCG5 and ABCG8 was decreased in CYP7A1 transgenic, LDL receptor-deficient mice fed a cholesterol-enriched diet...
  43. Nicolas A, Fatima S, Lamri A, Bellili Muñoz N, Halimi J, Saulnier P, et al. ABCG8 polymorphisms and renal disease in type 2 diabetic patients. Metabolism. 2015;64:713-9 pubmed publisher
    ..The ATP-binding cassette transporters G5 and G8 (ABCG5 and ABCG8) play an important role in intestinal sterol absorption and bile acid secretion...
  44. Mackay D, Eck P, Gebauer S, Baer D, Jones P. CYP7A1-rs3808607 and APOE isoform associate with LDL cholesterol lowering after plant sterol consumption in a randomized clinical trial. Am J Clin Nutr. 2015;102:951-7 pubmed publisher
    ..rs5882 in cholesteryl ester transfer protein (CETP) and rs4148217 in ATP-binding cassette subfamily G member 8 (ABCG8) did not associate with LDL cholesterol lowering...
  45. Kosters A, Frijters R, Schaap F, Vink E, Plosch T, Ottenhoff R, et al. Relation between hepatic expression of ATP-binding cassette transporters G5 and G8 and biliary cholesterol secretion in mice. J Hepatol. 2003;38:710-6 pubmed
    Mutations in genes encoding the ATP-binding cassette (ABC)-transporters ABCG5 and ABCG8 underlie sitosterolemia, which is characterized by elevated plasma levels of phytosterols due to increased intestinal absorption and impaired biliary ..
  46. Gylling H, Hallikainen M, Kolehmainen M, Toppinen L, Pihlajamaki J, Mykkanen H, et al. Cholesterol synthesis prevails over absorption in metabolic syndrome. Transl Res. 2007;149:310-6 pubmed
    ..and was related to variables of glucose and insulin action and to the common polymorphisms of the ABCG5 and ABCG8 genes...
  47. Field F, Born E, Mathur S. Stanol esters decrease plasma cholesterol independently of intestinal ABC sterol transporters and Niemann-Pick C1-like 1 protein gene expression. J Lipid Res. 2004;45:2252-9 pubmed
    ..ABCA1, ATP binding cassette G1 (ABCG1), ABCG5, ABCG8, and Niemann-Pick C1-like 1 (NPC1L1) mRNA levels were then estimated in duodenum, jejunum, and ileum...
  48. Stender S, Frikke Schmidt R, Nordestgaard B, Tybjærg Hansen A. The ABCG5/8 cholesterol transporter and myocardial infarction versus gallstone disease. J Am Coll Cardiol. 2014;63:2121-2128 pubmed publisher
  49. Zhu T, Corraze G, Plagnes Juan E, Quillet E, Dupont Nivet M, Skiba Cassy S. Regulation of genes related to cholesterol metabolism in rainbow trout (Oncorhynchus mykiss) fed plant-based diet. Am J Physiol Regul Integr Comp Physiol. 2017;:ajpregu.00179.2017 pubmed publisher
    ..trout fed V diet whereas expression of genes related to bile acid synthesis (cyp7a1) and cholesterol elimination (abcg8) were reduced...
  50. Wittenburg H, Lyons M, Li R, Kurtz U, Mossner J, Churchill G, et al. Association of a lithogenic Abcg5/Abcg8 allele on Chromosome 17 (Lith9) with cholesterol gallstone formation in PERA/EiJ mice. Mamm Genome. 2005;16:495-504 pubmed
    ..Significantly higher mRNA expression of Abcg5 and Abcg8 in strain PERA compared with strains I/Ln and DBA/2 further substantiated that the PERA allele of Abcg5/Abcg8 was ..
  51. Van Eck M, Twisk J, Hoekstra M, Van Rij B, Van der Lans C, Bos I, et al. Differential effects of scavenger receptor BI deficiency on lipid metabolism in cells of the arterial wall and in the liver. J Biol Chem. 2003;278:23699-705 pubmed
    ..However, a approximately 40% reduction in biliary cholesterol content was observed, and the expression of ABCG8 and ABCG5, ATP half-transporters implicated in the transport of sterols from the liver to the bile, was attenuated ..
  52. Wang Y, Su K, Sabeva N, Ji A, van der Westhuyzen D, Foufelle F, et al. GRP78 rescues the ABCG5 ABCG8 sterol transporter in db/db mice. Metabolism. 2015;64:1435-43 pubmed publisher
    ..Leptin signaling does not directly regulate G5G8 abundance. The loss of G5G8 in mice harboring defects in the leptin axis is likely associated with compromised ER function. ..
  53. Kawamura R, Saiki H, Tada H, Hata A. Acute myocardial infarction in a 25-year-old woman with sitosterolemia. J Clin Lipidol. 2018;12:246-249 pubmed publisher
    ..Genetic analysis revealed mutations in the ABCG8 gene. Ezetimibe treatment was initiated, and her LDL-C levels decreased substantially...
  54. Yu L, Gupta S, Xu F, Liverman A, Moschetta A, Mangelsdorf D, et al. Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion. J Biol Chem. 2005;280:8742-7 pubmed
    ..Biliary cholesterol secretion is mediated by the ATP-binding cassette (ABC) transporters ABCG5 (G5) and ABCG8 (G8) and is stimulated by cholesterol and by the non-cholesterol steroids cholate and diosgenin...
  55. Schmitz G, Langmann T, Heimerl S. Role of ABCG1 and other ABCG family members in lipid metabolism. J Lipid Res. 2001;42:1513-20 pubmed
    ..transporter A1 (ABCA1) molecule, ABC transporters belonging to the ABCG (White) subfamily (ABCG1, ABCG5, and ABCG8) have been shown to be critically involved in the regulation of lipid-trafficking mechanisms in macrophages, ..
  56. Wang D, Tazuma S, Cohen D, Carey M. Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse. Am J Physiol Gastrointest Liver Physiol. 2003;285:G494-502 pubmed
    ..Gene expression of intestinal sterol efflux transporters Abcg5 and Abcg8 was upregulated by feeding cholic acid but not by hydrophilic beta-muricholic acid nor by hydrophobic deoxycholic ..
  57. Heimerl S, Langmann T, Moehle C, Mauerer R, Dean M, Beil F, et al. Mutations in the human ATP-binding cassette transporters ABCG5 and ABCG8 in sitosterolemia. Hum Mutat. 2002;20:151 pubmed
    ..The disease is caused by mutations in two half size ATP-binding cassette transporters, ABCG5 and ABCG8. We have analyzed the genomic sequence of ABCG5 and ABCG8 in five well-characterized patients with Sitosterolemia...
  58. Kamou N, dubey m, Tzelepis G, Menexes G, Papadakis E, Karlsson M, et al. Investigating the compatibility of the biocontrol agent Clonostachys rosea IK726 with prodigiosin-producing Serratia rubidaea S55 and phenazine-producing Pseudomonas chlororaphis ToZa7. Arch Microbiol. 2016;198:369-77 pubmed publisher
    ..reverse transcription quantitative PCR showed an induction of seven genes (abcB1, abcB20, abcB26, abcC12, abcC12, abcG8 and abcG25) from subfamilies B, C and G...
  59. Lee M, Lu K, Hazard S, Yu H, Shulenin S, Hidaka H, et al. Identification of a gene, ABCG5, important in the regulation of dietary cholesterol absorption. Nat Genet. 2001;27:79-83 pubmed
    ..We previously mapped the STSL locus to human chromosome 2p21 and further localized it to a region of less than 2 cM bounded by markers D2S2294 ..
  60. Imai S, Kikuchi R, Kusuhara H, Yagi S, Shiota K, Sugiyama Y. Analysis of DNA methylation and histone modification profiles of liver-specific transporters. Mol Pharmacol. 2009;75:568-76 pubmed publisher
    ..e., from -213 to -48 CpGs for Abcg8) were hypomethylated in the liver and hypermethylated in the kidney and cerebrum...
  61. Kusuhara H, Sugiyama Y. ATP-binding cassette, subfamily G (ABCG family). Pflugers Arch. 2007;453:735-44 pubmed
    ..of the ATP-binding cassette, subfamily G (ABCG family), which has five members: ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8. The members consist of a single ABC cassette in the amino terminal followed by six putative transmembrane domains,..
  62. Repa J, Buhman K, Farese R, Dietschy J, Turley S. ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis. Hepatology. 2004;40:1088-97 pubmed
    ..and in the expression of adenosine triphosphate-binding cassette transporter G5 (ABCG5) and ABC transporter G8 (ABCG8)...
  63. Maqdasy S, El Hajjaji F, Baptissart M, Viennois E, Oumeddour A, Brugnon F, et al. Identification of the Functions of Liver X Receptor-β in Sertoli Cells Using a Targeted Expression-Rescue Model. Endocrinology. 2015;156:4545-57 pubmed publisher
    ..and Lxrα(-/-);Lxrβ(-/-):AMH-Lxrβ mice exhibit lipid accumulation in germ cells after the Abcg8 down-regulation, suggesting an intricate LXRβ-dependent cooperation between the Sertoli cells and germ cells to ..
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    ..Bilirubin is a major component of gallstones so we investigated whether these variants predict gallstone bilirubin content and overall risk for gallstones...
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    ..The excretion of cholesterol from the liver is regulated by adenosine triphosphate-binding cassette transporter ABCG8. A common genetic polymorphism D19H of ABCG8 associated with gallstone disease may be causatively related to the ..
  66. Engel T, Bode G, Lueken A, Knop M, Kannenberg F, Nofer J, et al. Expression and functional characterization of ABCG1 splice variant ABCG1(666). FEBS Lett. 2006;580:4551-9 pubmed
    ..Our results support that ABCG1(666) may in fact be the most prominent form of functional ABCG1 expressed in the human...
  67. Lally S, Tan C, Owens D, Tomkin G. Messenger RNA levels of genes involved in dysregulation of postprandial lipoproteins in type 2 diabetes: the role of Niemann-Pick C1-like 1, ATP-binding cassette, transporters G5 and G8, and of microsomal triglyceride transfer protein. Diabetologia. 2006;49:1008-16 pubmed
    ..1 (NPC1L1), which regulates cholesterol absorption; (2) ATP-binding cassette transporters G5 and G8 (ABCG5, ABCG8), which regulate cholesterol homeostasis through their ability to excrete enterocyte cholesterol back into the ..
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    ..Mutations in either, but not both, of two genes ABCG5 or ABCG8, comprising the STSL locus, are now known to cause this disease and their protein products are proposed to ..
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    Sitosterolemia is an autosomal recessive metabolic disease caused by mutations in ABCG5 or ABCG8 genes which encode for the (ATP)-binding cassette (ABC) transporters that are responsible for the trafficking of xenosterols...