ABCC9

Summary

Gene Symbol: ABCC9
Description: ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Alias: ABC37, ATFB12, CANTU, CMD1O, SUR2, ATP-binding cassette sub-family C member 9, ATP-binding cassette transporter sub-family C member 9, sulfonylurea receptor 2
Species: human

Top Publications

  1. doi Effects of ATP-sensitive potassium channels on the expression of P21, P27 and leptin
    Yaohui Wang
    Department of Pathophysiology, Zunyi Medical College, Zunyi, China
    J Huazhong Univ Sci Technolog Med Sci 29:8-11. 2009
  2. ncbi Toward understanding the assembly and structure of KATP channels
    L Aguilar-Bryan
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA
    Physiol Rev 78:227-45. 1998
  3. ncbi Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A
    Youhou Kang
    Department of Medicine, University of Toronto, Toronto M5S 1A8, Canada
    J Biol Chem 279:47125-31. 2004
  4. ncbi A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels
    N Inagaki
    Division of Molecular Medicine Center for Biomedical Science, Chiba University School of Medicine, Chuo Ku, Chiba 260, Japan
    Neuron 16:1011-7. 1996
  5. ncbi Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels
    W A Chutkow
    Department of Medicine, Howard Hughes Medical Institute, Chicago, Illinois, USA
    Diabetes 45:1439-45. 1996
  6. pmc ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating
    Martin Bienengraeber
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, Minnesota 55905, USA
    Nat Genet 36:382-7. 2004
  7. ncbi Physical association between recombinant cardiac ATP-sensitive K+ channel subunits Kir6.2 and SUR2A
    E Lorenz
    Department of Internal Medicine, Mayo Clinic, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Mol Cell Cardiol 31:425-34. 1999
  8. doi Patents related to therapeutic activation of K(ATP) and K(2P) potassium channels for neuroprotection: ischemic/hypoxic/anoxic injury and general anesthetics
    Susan I V Judge
    University of Maryland School of Medicine, MS Center of Excellence East, VA Maryland Health Care System, Department of Neurology, BRB 12 040, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Expert Opin Ther Pat 19:433-60. 2009
  9. ncbi Molecular mechanisms underlying ketamine-mediated inhibition of sarcolemmal adenosine triphosphate-sensitive potassium channels
    Takashi Kawano
    Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan
    Anesthesiology 102:93-101. 2005
  10. ncbi Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development
    Shu Feng Zhou
    Division of Chinese Medicine, School of Health Sciences, WHO Collaborating Center for Traditional Medicine, RMIT University, Victoria, Australia
    Curr Med Chem 15:1981-2039. 2008

Scientific Experts

Detail Information

Publications130 found, 100 shown here

  1. doi Effects of ATP-sensitive potassium channels on the expression of P21, P27 and leptin
    Yaohui Wang
    Department of Pathophysiology, Zunyi Medical College, Zunyi, China
    J Huazhong Univ Sci Technolog Med Sci 29:8-11. 2009
    ..The results showed that the expression of SUR2, not SUR1 was detected in adipose tissue, preadipocytes and adipocytes...
  2. ncbi Toward understanding the assembly and structure of KATP channels
    L Aguilar-Bryan
    Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA
    Physiol Rev 78:227-45. 1998
    ..The availability of cloned KATP channel genes opens the way for characterization of this family of ion channels and identification of additional genetic defects...
  3. ncbi Syntaxin-1A inhibits cardiac KATP channels by its actions on nucleotide binding folds 1 and 2 of sulfonylurea receptor 2A
    Youhou Kang
    Department of Medicine, University of Toronto, Toronto M5S 1A8, Canada
    J Biol Chem 279:47125-31. 2004
    ....
  4. ncbi A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels
    N Inagaki
    Division of Molecular Medicine Center for Biomedical Science, Chiba University School of Medicine, Chuo Ku, Chiba 260, Japan
    Neuron 16:1011-7. 1996
    We have cloned an isoform of the sulfonylurea receptor (SUR), designated SUR2. Coexpression of SUR2 and the inward rectifier K+ channel subunit Kir6...
  5. ncbi Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels
    W A Chutkow
    Department of Medicine, Howard Hughes Medical Institute, Chicago, Illinois, USA
    Diabetes 45:1439-45. 1996
    ..Northern blotting showed that the highest expression of the SUR2 isoforms is in the heart and skeletal muscle, with lower levels in all other tissues...
  6. pmc ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating
    Martin Bienengraeber
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, Minnesota 55905, USA
    Nat Genet 36:382-7. 2004
    ..with heart failure and rhythm disturbances due to idiopathic dilated cardiomyopathy identified two mutations in ABCC9, which encodes the regulatory SUR2A subunit of the cardiac K(ATP) channel...
  7. ncbi Physical association between recombinant cardiac ATP-sensitive K+ channel subunits Kir6.2 and SUR2A
    E Lorenz
    Department of Internal Medicine, Mayo Clinic, Mayo Foundation, Rochester, Minnesota 55905, USA
    J Mol Cell Cardiol 31:425-34. 1999
    ..The demonstration of complex formation between Kir6.2 and SUR2A indicates that the structural basis for channel function may rely on direct physical interaction of the two subunits...
  8. doi Patents related to therapeutic activation of K(ATP) and K(2P) potassium channels for neuroprotection: ischemic/hypoxic/anoxic injury and general anesthetics
    Susan I V Judge
    University of Maryland School of Medicine, MS Center of Excellence East, VA Maryland Health Care System, Department of Neurology, BRB 12 040, 655 West Baltimore Street, Baltimore, MD 21201, USA
    Expert Opin Ther Pat 19:433-60. 2009
    ..which belong to the family of inwardly rectifying K(+) channels (K(ir)) and contain a sulfonylurea subunit (SUR1 or SUR2) combined with either K(ir)6.1 (KCNJ8) or K(ir)6...
  9. ncbi Molecular mechanisms underlying ketamine-mediated inhibition of sarcolemmal adenosine triphosphate-sensitive potassium channels
    Takashi Kawano
    Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan
    Anesthesiology 102:93-101. 2005
    ..1 or Kir6.2) and sulfonylurea receptors (SUR1, SUR2A, or SUR2B)...
  10. ncbi Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug development
    Shu Feng Zhou
    Division of Chinese Medicine, School of Health Sciences, WHO Collaborating Center for Traditional Medicine, RMIT University, Victoria, Australia
    Curr Med Chem 15:1981-2039. 2008
    ..ABCC7 is cystic fibrosis transmembrane conductance regulator; ABCC8 and ABCC9 are the sulfonylurea receptors which constitute the ATP-sensing subunits of a complex potassium channel...
  11. pmc Differential K(ATP) channel pharmacology in intact mouse heart
    Alexey V Glukhov
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    J Mol Cell Cardiol 48:152-60. 2010
    Classically, cardiac sarcolemmal K(ATP) channels have been thought to be composed of Kir6.2 (KCNJ11) and SUR2A (ABCC9) subunits...
  12. pmc Phosphoinositides decrease ATP sensitivity of the cardiac ATP-sensitive K(+) channel. A molecular probe for the mechanism of ATP-sensitive inhibition
    Z Fan
    Department of Physiology, University of Tennessee, College of Medicine, Memphis, Tennessee 38163, USA
    J Gen Physiol 114:251-69. 1999
    ..clamp technique in cardiac myocytes and in COS-1 cells in which the cardiac isoform of the sulfonylurea receptor, SUR2, was coexpressed with the inwardly rectifying channel Kir6.2...
  13. pmc Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channels
    Richard D Rainbow
    Department of Cell Physiology and Pharmacology, University of Leicester, University Road, Leicester LE1 9HN, UK
    Biochem J 379:173-81. 2004
    ..ATP- and glibenclamide-sensitive K+ currents were decreased in HEK-293 cells expressing full-length Kir6 and SUR2 subunits that were transiently transfected with fragments rSUR2A-CTA, rSUR2A-CTC and rSUR2A-CTE (residues 1294-1359)..
  14. pmc Glucose-receptive neurones in the rat ventromedial hypothalamus express KATP channels composed of Kir6.1 and SUR1 subunits
    K Lee
    Parke Davis Neuroscience Research Centre, Cambridge University Forvie Site, Cambridge CB2 2QB, UK
    J Physiol 515:439-52. 1999
    ..1 and SUR1 but not Kir6.2 or SUR2. 6...
  15. ncbi Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction
    Shigeo Horinaka
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321 0293, Japan
    Cardiovasc Drugs Ther 18:13-22. 2004
    ..At 24 hours after treatment, eNOS, iNOS, and SUR2 mRNA levels and eNOS, iNOS expression in the left ventricle were determined by reverse transcription polymerase ..
  16. pmc Coassembly of different sulfonylurea receptor subtypes extends the phenotypic diversity of ATP-sensitive potassium (KATP) channels
    Adam Wheeler
    Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
    Mol Pharmacol 74:1333-44. 2008
    ..SUR1- but not SUR2-containing channels are highly sensitive to metabolic inhibition and diazoxide, whereas SUR2 channels are sensitive ..
  17. ncbi Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescence
    C Kast
    Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
    J Biol Chem 272:26479-87. 1997
    ..cadmium factor 1 and yeast oligomycin resistance I proteins, and the mammalian sulfonylurea receptors SUR1 and SUR2. Hydropathy analysis of these proteins predicts a unique membrane-associated region at the amino terminus followed ..
  18. doi Sesquiterpenoids from antidiabetic Psacalium decompositum block ATP sensitive potassium channels
    Maria G Campos
    Unit of Medical Research in Pharmacology, National Medical Center SXXI, IMSS, Mexico, Mexico
    J Ethnopharmacol 123:489-93. 2009
    ....
  19. ncbi Spontaneous coronary vasospasm in KATP mutant mice arises from a smooth muscle-extrinsic process
    Rahul Kakkar
    Department of Medicine, The University of Chicago, IL 60637, USA
    Circ Res 98:682-9. 2006
    ..Two transgenic founder lines were generated and independently bred to sulfonylurea receptor 2 (SUR2) null mice to generate mice that restored expression of KATP channels in vascular smooth muscle...
  20. pmc Suppressed Ca2+/CaM/CaMKII-dependent K(ATP) channel activity in primary afferent neurons mediates hyperalgesia after axotomy
    Takashi Kawano
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Proc Natl Acad Sci U S A 106:8725-30. 2009
    ..Immunohistochemistry identified the presence of K(ATP) channel subunits SUR1, SUR2, and Kir6.2 but not Kir6.1, and pCaMKII in neurofilament 200-positive DRG somata...
  21. pmc The molecular basis of the specificity of action of K(ATP) channel openers
    C Moreau
    CEA, DBMS, Biophysique Moléculaire et Cellulaire UMR CNRS UJF CEA 5090, 17 rue des Martyrs, 38054 Grenoble, France
    EMBO J 19:6644-51. 2000
    ..g. pinacidil, cromakalim, nicorandil) act specifically on the SUR2 muscle isoforms but, except for diazoxide, remain ineffective on the SUR1 neuronal/pancreatic isoform...
  22. ncbi Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closure
    H Dorschner
    Institut fur Pharmakologie und Toxikologie, Universität Braunschweig, Mendelssohnstrabetae 1, 38106 Braunschweig, Germany
    Mol Pharmacol 55:1060-6. 1999
    ..Affinities of sulfonylureas for rat SUR2A, rat or human SUR2B, and a SUR2 chimera containing the C-terminal 42 amino acids of SUR1 did not differ significantly, implying that the C terminus ..
  23. ncbi Involvement of ATP-sensitive potassium channels in proliferation and differentiation of rat preadipocytes
    Yao Hui Wang
    Department of Pathophysiology, Huazhong University of Science and Technology, Wuhan 430030, China
    Sheng Li Xue Bao 59:8-12. 2007
    ..We examined the expression of sulphonylurea receptor 2 (SUR2) mRNA in preadipocytes and adipocytes obtained by inducing for 5 d and the effects of the inhibitor (glibenclamide) ..
  24. doi Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidil
    Katie Shorter
    Department of Biomedical Sciences, University of Bradford, Bradford, BD7 1DP, UK
    FASEB J 22:1725-36. 2008
    ..2/SUR1 and Kir6.1/SUR2B; minoxidil only stimulates SUR2 channels...
  25. ncbi Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat
    S Horinaka
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan
    J Cardiovasc Pharmacol 38:200-10. 2001
    ..e., an ATP-binding cassette protein sulfonylurea receptor (SUR2) and a pore-forming inward rectifier (Kir6.1 or 6.2)...
  26. pmc Molecular identification and functional characterization of a mitochondrial sulfonylurea receptor 2 splice variant generated by intraexonic splicing
    Bin Ye
    Department of Medicine, University of Wisconsin, Madison, WI 53706, USA
    Circ Res 105:1083-93. 2009
    ..Cardioprotective pathways may involve a mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel but its composition is not fully understood...
  27. doi K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS production
    Juan Xie
    Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, People s Republic of China
    J Neurosci Res 88:428-37. 2010
    ..However, cromakalim (Cro), an opener of Kir6.1/SUR2 but not Kir6.2/SUR1 K(ATP) channels, failed to protect against MPP(+)-induced cytotoxicity...
  28. doi Iptakalim protects against hypoxic brain injury through multiple pathways associated with ATP-sensitive potassium channels
    H L Zhu
    Department of Environmental Medicine, Tianjin Institute of Hygiene and Environmental Medicine, Tianjin 300050, China
    Neuroscience 157:884-94. 2008
    ..In this study, adult Wistar rats were treated with iptakalim, a new KATP channel opener, which is selective for SUR2 type KATP channels, by intragastric administration at doses of 2, 4, or 8 mg/kg/day for 7 days before being exposed ..
  29. ncbi Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins
    Roger G Deeley
    Division of Cancer Biology and Genetics, Cancer Research Institute and Department of Biochemistry, Queen s University Kingdom, Ontario, Canada
    Physiol Rev 86:849-99. 2006
    ..with the cystic fibrosis conductance regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) comprise the 13 members of the human "C" branch of the ATP binding cassette (ABC) superfamily...
  30. ncbi [Molecular and functional diversity of ATP-sensitive K+ channels: the pathophysiological roles and potential drug targets]
    Haruaki Nakaya
    Department of Pharmacology, Chiba University Graduate School of Medicine, Japan
    Nihon Yakurigaku Zasshi 122:243-50. 2003
    ..1 or Kir6.2) and the regulatory subunit sulfonylurea receptors (SUR1 or SUR2)...
  31. doi Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts
    Najate Benamer
    Institut de Physiologie et Biologie Cellulaires, CNRS UMR 6187, Universite de Poitiers, France
    J Mol Cell Cardiol 46:508-17. 2009
    ..Among potassium channel transcripts which were screened by high-throughput real-time PCR, SUR2 and Kir6.1 mRNAs were found to be the most abundant in ventricular fibroblasts...
  32. pmc Identification of an ATP-sensitive potassium channel current in rat striatal cholinergic interneurones
    K Lee
    Parke Davis Neuroscience Research Centre, Cambridge University Forvie Site, UK
    J Physiol 510:441-53. 1998
    ..1 and SUR1 but not Kir6.2 or SUR2. 6...
  33. ncbi A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel
    S Isomoto
    Department of Pharmacology II, Faculty of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565, Japan
    J Biol Chem 271:24321-4. 1996
    ..Sequence analysis indicated that this clone is a variant of cardiac type sulfonylurea receptor (SUR2)...
  34. pmc Metabolomic, transcriptional, hormonal, and signaling cross-talk in superroot2
    Marc Morant
    Plant Biochemistry Laboratory, Department of Plant Biology and Biotechnology, University of Copenhagen, 40 Thorvaldsensvej, Frederiksberg C, Copenhagen, Denmark
    Mol Plant 3:192-211. 2010
    Auxin homeostasis is pivotal for normal plant growth and development. The superroot2 (sur2) mutant was initially isolated in a forward genetic screen for auxin overproducers, and SUR2 was suggested to control auxin conjugation and thereby ..
  35. doi KATP channel subunits are expressed in the epididymal epithelium in several mammalian species
    Pascale Lybaert
    Laboratory of Experimental Hormonology, Faculty of Medicine, Universite Libre de Bruxelles ULB, B 1070 Brussels, Belgium
    Biol Reprod 79:253-61. 2008
    ..A positive immunostaining for Kir6.2 (KCNJ11) and SUR2 (ABCC9) was observed by immunoenzymatic and immunofluorescent approaches in the principal epithelial cells throughout all ..
  36. doi The role of survivin2 in primitive hematopoiesis during zebrafish development
    A C H Ma
    Division of Haematology and Bone Marrow Transplantation, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
    Leukemia 23:712-20. 2009
    ..In this study, we examined survivin2 (sur2) with particular reference to its role in primitive hematopoiesis during zebrafish development...
  37. pmc Mice lacking sulfonylurea receptor 2 (SUR2) ATP-sensitive potassium channels are resistant to acute cardiovascular stress
    Douglas Stoller
    Committee on Cell Physiology, The University of Chicago, Chicago, IL 60637, USA
    J Mol Cell Cardiol 43:445-54. 2007
    ..Cardiomyocyte K(ATP) channels are composed of the pore-forming Kir6.2 subunit and the regulatory sulfonylurea receptor 2 (SUR2)...
  38. pmc Identification of two Mycobacterium tuberculosis H37Rv ORFs involved in resistance to killing by human macrophages
    B H Miller
    Department of Microbiology and Immunology, Emory University School of Medicine and Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    BMC Microbiol 1:26. 2001
    ..tuberculosis H37Rv genomic DNA, was passed through THP-1 human macrophages three times...
  39. ncbi Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes
    Cecilia Bondjers
    Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden
    FASEB J 20:1703-5. 2006
    ..1 (also known as Kcnj8) and sulfonylurea receptor 2, (SUR2, also known as Abcc9), both part of the same channel complex, as well as delta homologue 1 (DLK1) ..
  40. pmc Impaired exercise tolerance and skeletal muscle myopathy in sulfonylurea receptor-2 mutant mice
    Douglas Stoller
    Committee on Cellular and Molecular Physiology, The University of Chicago, Chicago, Illinois 60637, USA
    Am J Physiol Regul Integr Comp Physiol 297:R1144-53. 2009
    ..b>SUR2 mutant mice lack full-length K(ATP) channels in striated and smooth muscle and display a complex phenotype of ..
  41. ncbi Post-infarction treatment with simvastatin reduces myocardial no-reflow by opening of the KATP channel
    Yue jin Yang
    Department of Cardiology, Cardiovascular Institute and Fu Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Bei Li Shi Road 167, West City District, Beijing, 100037, China
    Eur J Heart Fail 9:30-6. 2007
    ..However, it remains unknown whether post-infarction treatment with simvastatin can also reduce myocardial no-reflow for which suppression of adenosine triphosphate-sensitive K+ (K(ATP)) channel opening is an important mechanism...
  42. ncbi Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit
    Jennitte L Stevens
    Molecular Biology Institute, University of California, Los Angeles, 611 Charles Young Drive East, Los Angeles, CA 90095, USA
    Science 296:755-8. 2002
    b>Sur2 is a metazoan Mediator subunit that interacts with the adenovirus E1A protein and functions in a mitogen-activated protein kinase pathway required for vulva development in Caenorhabditis elegans...
  43. doi ATP-sensitive potassium currents in rat primary afferent neurons: biophysical, pharmacological properties, and alterations by painful nerve injury
    T Kawano
    Department of Anesthesiology, Anesthesia Research MEB, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroscience 162:431-43. 2009
    ..Using specific antibodies, we identified SUR1, SUR2, and Kir6.2 but not Kir6.1 subunits in DRGs...
  44. pmc A novel Sit4 phosphatase complex is involved in the response to ceramide stress in yeast
    Alexandra Woodacre
    Department of Genetics, University of Leicester, Leicester, UK
    Oxid Med Cell Longev 2013:129645. 2013
    ..a shift towards nonhydroxylated forms of long chain bases and sphingolipids, suggesting regulation of hydroxylase (SUR2) or ceramide synthase by Sit4p...
  45. doi Localization of the ATP-sensitive K(+) channel regulatory subunits SUR2A and SUR2B in the rat brain
    Ming Zhou
    Department of Anatomy, Akita University Graduate School of Medicine and Faculty of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Neurosci Res 74:91-105. 2012
    ..b>SUR2 mRNA is widely expressed in many neurons and glial cells as revealed by in situ hybridization histochemistry...
  46. doi Mutation of KCNJ8 in a patient with Cantú syndrome with unique vascular abnormalities - Support for the role of K(ATP) channels in this condition
    Catherine A Brownstein
    Division of Genetics and Genomics, The Manton Center for Orphan Disease Research, Boston Children s Hospital, Harvard Medical School, Boston, MA, USA Electronic address
    Eur J Med Genet 56:678-82. 2013
    ..Recently, the KATP gene ABCC9 (SUR2, NM_020297) has been associated with the multi-organ disorder Cantú syndrome or hypertrichotic ..
  47. ncbi Autosomal-dominant hypertension with type E brachydactyly is caused by rearrangement on the short arm of chromosome 12
    Sylvia Bahring
    Medical Faculty of the Charite, The Clinical Research Center, Franz Volhard Clinic and the Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Hypertension 43:471-6. 2004
    ..1, its regulator the sulfonyl urea receptor SUR2, and the phosphodiesterase PDE3A. We further studied 6 affected and 4 nonaffected persons...
  48. pmc Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides
    Annette Hambrock
    Department of Pharmacology, Medical Faculty, University of Tubingen, Wilhelmstr 56, D 72074 Tubingen, Germany
    Br J Pharmacol 136:995-1004. 2002
    ..Here, we report on the negative allosteric modulation by MgATP and MgADP of glibenclamide binding to SUR1 and to SUR2 mutants with high glibenclamide affinity, SUR2A(Y1206S) and SUR2B(Y1206S)...
  49. ncbi The stereoenantiomers of a pinacidil analog open or close cloned ATP-sensitive K+ channels
    Ulf Lange
    Department of Pharmacology and Toxicology, University of Tubingen, Wilhelmstrasse 56, D 72074 Tubingen, Germany
    J Biol Chem 277:40196-205. 2002
    ..2/SUR channels. In patch clamp experiments, the R-enantiomer (PNU-96293) inhibited Kir6.2/SUR2 channels (IC(50) approximately 50 nm in the whole cell configuration), whereas the S-enantiomer (PNU-96179) was a ..
  50. doi A-62176, a potent topoisomerase inhibitor, inhibits the expression of human epidermal growth factor receptor 2
    Hye Lin Kim
    College of Pharmacy, Division of Life and Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea
    Cancer Lett 325:72-9. 2012
    ..suggest that A-62176 inhibits the interaction between the ESX, an ets transcription factor, and its co-activator Sur2, leading to the attenuation of HER2-mediated phosphorylation of MAPK/Akt...
  51. pmc Promoter DNA methylation regulates murine SUR1 (Abcc8) and SUR2 (Abcc9) expression in HL-1 cardiomyocytes
    Naheed Fatima
    Department of Anatomy, Physiology and Genetics, Uniformed Services University of the Health Sciences, F Edward Hebert School of Medicine, Bethesda, Maryland, United States of America
    PLoS ONE 7:e41533. 2012
    Two mammalian genes encode the SURx (SUR1, Abcc8 and SUR2, Abcc9) subunits that combine with Kir6.2 (Kcnj11) subunits to form the ATP-sensitive potassium (KATP) channel in cardiac myocytes...
  52. pmc CRS-MIS in Candida glabrata: sphingolipids modulate echinocandin-Fks interaction
    Kelley R Healey
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, PA 19129, USA
    Mol Microbiol 86:303-13. 2012
    ..DHS) and phytosphingosine (PHS) levels, and consistent with this sequencing revealed fen1, sur4, ifa38 and sur2 mutations. Moreover, exogenous DHS or PHS conferred a CRS-MIS phenotype on wild-type C. glabrata...
  53. ncbi Cloning and functional characterization of the SUR2/SYR2 gene encoding sphinganine hydroxylase in Pichia ciferrii
    Jung Hoon Bae
    Laboratory of Microbial Functions, Korea Research Institute of Bioscience and Biotechnology, Yusong, Taejon 305 333, Korea
    Yeast 21:437-43. 2004
    Saccharomyces cerevisiae sphinganine C4-hydroxylase encoded by the SUR2 gene catalyses the conversion of sphinganine to phytosphingosine. We isolated the SUR2 gene from Pichia ciferrii using nucleotide sequence homology to S...
  54. pmc Activation domain-mediator interactions promote transcription preinitiation complex assembly on promoter DNA
    Greg T Cantin
    Molecular Biology Institute and Department of Microbiology, Immunology and Molecular Genetics, 611 Charles E Young Drive East, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 100:12003-8. 2003
    ..that the major adenovirus E1A and mitogen-activated protein kinase-phosphorylated Elk1 activation domains bind to Sur2 uniquely among the metazoan mediator subunits and the development of transcriptionally active nuclear extracts from ..
  55. pmc Fibroblast KATP currents modulate myocyte electrophysiology in infarcted hearts
    Najate Benamer
    Leon H Charney Division of Cardiology, New York University School of Medicine, New York, New York 10016, USA
    Am J Physiol Heart Circ Physiol 304:H1231-9. 2013
    ..4 ± 7.5 pA/pF at 50 mV) in sMI-Fb that was inhibited with 10 μmol/l glibenclamide. Kir6.2 and SUR2 transcript levels were elevated in sMI-Fb. Treatment with Kir6...
  56. doi Expression and purification of a soluble ESX-binding core domain of SUR2
    Kyung Hwa Jeon
    College of Pharmacy, Ewha Womans University, Seoul, Korea
    Prep Biochem Biotechnol 43:364-75. 2013
    For HER2 overexpression, the ESX transcription factor must interact with both the HER2 promoter and Sur2, a subunit of human mediator complex, using its Ets domain and transactivation domain, respectively...
  57. pmc Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle
    Anlong Li
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO
    J Am Heart Assoc 2:e000365. 2013
    KATP channels, assembled from pore-forming (Kir6.1 or Kir6.2) and regulatory (SUR1 or SUR2) subunits, link metabolism to excitability. Loss of Kir6.2 results in hypoglycemia and hyperinsulinemia, whereas loss of Kir6...
  58. pmc Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiae
    S Kim
    Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
    Genetics 156:1519-29. 2000
    ..the biological roles of these molecules, we created disruption mutants for LCB4, LCB5, DPL1, YSR2, YSR3, and SUR2. LCB4 and LCB5 encode kinases that phosphorylate long chain bases...
  59. doi Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammation
    Fang Zhou
    Jiangsu Key Laboratory of Neurodegeneration, Department of Anatomy Histology, Pharmacology Nanjing Medical University Nanjing, Jiangsu, P R China
    J Cell Mol Med 12:1559-70. 2008
    ..The present study demonstrates that rat primary cultured MG expressed Kir6.1 and SUR2 subunits of K(ATP) channel, which was identical to that expressed in BV-2 microglial cell line...
  60. pmc Disruption of Sur2-containing K(ATP) channels enhances insulin-stimulated glucose uptake in skeletal muscle
    W A Chutkow
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 98:11760-4. 2001
    ..used a gene-targeting strategy to generate mice with a disruption in the muscle-specific K(ATP) regulatory subunit, SUR2. Insertional mutagenesis of the Sur2 locus generated homozygous null (Sur2(-/-)) mice and heterozygote (Sur2(+/-)) ..
  61. ncbi Molecular characterization of human SUR2-containing K(ATP) channels
    R Davis-Taber
    Neurological and Urological Diseases Research, Dept 47C, APgA, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
    Gene 256:261-70. 2000
    The distribution of human sulfonylurea receptor-2 (SUR2)-containing K(ATP) channels was investigated using reverse transcriptase-polymerase chain reaction (RT-PCR)...
  62. pmc Susceptibility of ATP-sensitive K+ channels to cell stress through mediation of phosphoinositides as examined by photoirradiation
    Z Fan
    The Department of Physiology, University of Tennessee, College of Medicine, Memphis, TN 38163, USA
    J Physiol 529:707-21. 2000
    ..were recorded from cell-attached and inside-out patches of rat ventricular myocytes and COS-1 cells coexpressing SUR2 and Kir6.2. KATP channel activity increased within < 1 min upon irradiation...
  63. ncbi Putative subunits of the rat mesangial KATP: a type 2B sulfonylurea receptor and an inwardly rectifying K+ channel
    Balazs Szamosfalvi
    Department of Medicine, Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, Michigan 48202, USA
    Kidney Int 61:1739-49. 2002
    ..Because these responses likely resulted from the binding of sulfonylurea to a mesangial SUR2, we subsequently documented [3H]-glibenclamide binding to MC and the gene expression of several mesangial SUR2 ..
  64. doi Gene expression profiling of ABC transporters in dermal fibroblasts of pseudoxanthoma elasticum patients identifies new candidates involved in PXE pathogenesis
    Doris Hendig
    Institut fur Laboratoriums und Transfusionsmedizin, Herz und Diabeteszentrum Nordrhein Westfalen, Universitatsklinik der Ruhr Universitat Bochum, Bad Oeynhausen, Germany
    Lab Invest 88:1303-15. 2008
    ..Seven genes (ABCA6, ABCA9, ABCA10, ABCB5, ABCC2, ABCC9 and ABCD2) were induced, whereas the gene expression of one gene (ABCA3) was decreased, comparing controls and PXE ..
  65. ncbi Novel insulin/GIP co-producing cell lines provide unexpected insights into Gut K-cell function in vivo
    Erin B Ramshur
    Department of Internal Medicine, Division of Metabolism, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Physiol 192:339-50. 2002
    ..The K-cell lines also express relatively low levels of Kir 6.1, Kir 6.2, SUR1, and SUR2 suggesting secretion is independent of K(ATP) channels...
  66. doi Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channel
    Betty Ng
    Department of Medicine, University of Toronto, Room 7310, Medical Sciences Building, Toronto, ON, Canada
    Cardiovasc Res 80:365-74. 2008
    ..Here, we examined whether Syn-1A would influence non-specific (diazoxide) and SUR2-specific KCOs [N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine (P-1075) and cromakalim] on cardiac myocyte K(..
  67. pmc Effect of propofol on cardiac function and gene expression after ischemic-reperfusion in isolated rat heart
    Youn Jin Kim
    Department of Anesthesiology and Pain Medicine, School of Medicine, Ewha Womans University, Seoul, Korea
    Korean J Anesthesiol 58:153-61. 2010
    ..The aim of this study was to examine the cardiac function and transcriptional response of the heart to propofol after ischemia-reperfusion...
  68. pmc Characterization of an ATP-sensitive K(+) channel in rat carotid body glomus cells
    Donghee Kim
    Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, United States
    Respir Physiol Neurobiol 177:247-55. 2011
    ..Reverse transcriptase-PCR and immunocytochemistry showed that Kir6.1, Kir6.2, SUR1 and SUR2 were expressed in CB glomus cells as well as in non-glomus cells...
  69. doi Levcromakalim and MgGDP activate small conductance ATP-sensitive K+ channels of K+ channel pore 6.1/sulfonylurea receptor 2A in pig detrusor smooth muscle cells: uncoupling of cAMP signal pathways
    Shunichi Kajioka
    University Department of Pharmacology, Oxford, United Kingdom
    J Pharmacol Exp Ther 327:114-23. 2008
    ..The 12 pS K(+) channel activated by levcromakalim in pig detrusor smooth muscle cells is a K(ATP) channel. The predominant expression of SUR2A can account for the lack of effect of neurotransmitters related to cAMP...
  70. doi Diazoxide reverses the enhanced expression of KATP subunits in cholinergic neurons caused by exposure to Aβ₁₋₄₂
    Guozhao Ma
    Department of Neurology, Provincial Hospital affiliated to Shandong University, No 324 Jingwu Weiqi Road, 250021 Jinan, Shandong, People s Republic of China
    Neurochem Res 34:2133-40. 2009
    ..The subunits of KATP: Kir6.1, Kir6.2, SUR1 and SUR2 expressing change was observed by double Immunofluorescence and immunoblotting in cultured cholinergic neurons from ..
  71. ncbi The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2A
    Y Kono
    Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
    Pflugers Arch 440:692-8. 2000
    ..2 to MgATP (IC50=95.5+/-49.6 microM versus 18.9+/-5.0 microM). These results suggest that Kir6.1 and Kir6.2 are endowed with the potential to form a heteromeric KATP channel, which has a low sensitivity to MgATP...
  72. ncbi Yeast mutants affected in viability upon starvation have a modified phospholipid composition
    L Desfarges
    Laboratoire de Genetique, Talence, France
    Yeast 9:267-77. 1993
    ..Ten mutants were obtained, ranged amongst four complementation groups, named SUR1, SUR2, SUR3 and SUR4...
  73. ncbi SYR2, a gene necessary for syringomycin growth inhibition of Saccharomyces cerevisiae
    P Cliften
    Department of Biology and Program in Molecular Biology, Utah State University, Logan 84322 5305, USA
    Microbiology 142:477-84. 1996
    ..SYR2 was identical to SUR2, which is involved in survival during nutritional starvation...
  74. pmc Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice
    Adebowale Adebiyi
    Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
    Am J Physiol Heart Circ Physiol 301:H1360-8. 2011
    ..In the present study, we used a genetic model to investigate the physiological functions of SUR2-containing K(ATP) channels in mediating vasodilation to hypoxia, oxygen and glucose deprivation (OGD) or metabolic ..
  75. doi Ontogeny of sulfonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium
    N Lovasz
    Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary
    Reproduction 142:175-81. 2011
    ..to examine the expression and role of sulfonylurea-binding regulatory subunits 1 (SUR1 (ABCC8)) and 2 (SUR2 (ABCC9)) of the K(ATP) channels in the pregnant rat myometrium with particular regard to the contractility...
  76. pmc Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels
    Guo Hua Liang
    Dept of Physiology, Univ of Tennessee Health Science Ctr, Memphis, TN 38163, USA
    Am J Physiol Heart Circ Physiol 300:H2088-95. 2011
    ..also studied in pressurized resistance-size cerebral arteries of mice with a genetic deletion in the gene encoding SUR2 (SUR2 null)...
  77. pmc Human oocytes express ATP-sensitive K(+) channels
    Qingyou Du
    Division of Medical Sciences MACHS, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
    Hum Reprod 25:2774-82. 2010
    ..x (Kir6.1 or Kir6.2) and regulatory, SURx (SUR2A, SUR2B or SUR1), subunits that associate in different combinations. The objective of this study was to determine whether mammalian oocytes (human, bovine, porcine) express K(ATP) channels...
  78. pmc Cardiomyocyte sulfonylurea receptor 2-KATP channel mediates cardioprotection and ST segment elevation
    Douglas A Stoller
    Committee on Cellular and Molecular Physiology, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Heart Circ Physiol 299:H1100-8. 2010
    ..Mice deleted for the first nucleotide binding region of sulfonylurea receptor 2 (SUR2) are referred to as SUR2 null since they lack full-length SUR2 and glibenclamide-responsive K(ATP) ..
  79. doi Gender-related differences in ion-channel and transporter subunit expression in non-diseased human hearts
    Nathalie Gaborit
    INSERM, UMR915, l institut du thorax, Nantes, France
    J Mol Cell Cardiol 49:639-46. 2010
    ..3, Kv1.4, KChIP2, SUR2 and Kir6.2, as well as lower expression of connexin43 and phospholamban...
  80. pmc A novel custom resequencing array for dilated cardiomyopathy
    Rebekah S Zimmerman
    Laboratory for Molecular Medicine, Partners Healthcare Center for Personalized Genetic Medicine, Cambridge, Massachusetts 02139, USA
    Genet Med 12:268-78. 2010
    ..Novel sequencing platforms have now opened up avenues for more comprehensive diagnostic testing while simultaneously decreasing test cost and turn around time...
  81. pmc KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomy
    Vasiliki Zoga
    Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Mol Pain 6:6. 2010
    ....
  82. pmc SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandil
    T Shindo
    Department of Pharmacology II, Faculty of Medicine, Osaka University, Suita, Japan
    Br J Pharmacol 124:985-91. 1998
    ....
  83. doi Genes controlling postural changes in blood pressure: comprehensive association analysis of ATP-sensitive potassium channel genes KCNJ8 and ABCC9
    Justine A Ellis
    Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia
    Physiol Genomics 40:184-8. 2010
    ..genomewide linkage analysis suggests a region on chromosome 12p that harbors two strong candidate genes, KCNJ8 and ABCC9, encoding the channel-forming inward rectifier subunit Kir6...
  84. pmc Cardiac sarcolemmal K(ATP) channels: Latest twists in a questing tale!
    Haixia Zhang
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Mol Cell Cardiol 48:71-5. 2010
    ..1, KCNJ8, and Kir6.2 KCNJ11) with sulfonylurea receptors (SUR1, ABCC8, and SUR2, ABCC9) of the ABCC protein sub-family, has led to the elucidation of many details of channel gating and pore properties, ..
  85. pmc Sulfonylurea receptor-dependent and -independent pathways mediate vasodilation induced by ATP-sensitive K+ channel openers
    Adebowale Adebiyi
    Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
    Mol Pharmacol 74:736-43. 2008
    ..mechanisms by which diazoxide and pinacidil induce vasodilation by studying diameter regulation of wild-type [SUR2(+/+)] and sulfonylurea receptor (SUR) 2-deficient [SUR2(-/-)] mouse myogenic mesenteric arteries...
  86. ncbi Investigation of the subunit composition and the pharmacology of the mitochondrial ATP-dependent K+ channel in the brain
    Zsombor Lacza
    Department of Physiology Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Brain Res 994:27-36. 2003
    ..In contrast, we found no evidence for the presence of either known sulfonylurea receptors (SUR1 or SUR2) in the mitochondria...
  87. ncbi Identification and characterization of a novel member of the ATP-sensitive K+ channel subunit family, Kir6.3, in zebrafish
    Changliang Zhang
    Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    Physiol Genomics 24:290-7. 2006
    ..We also identified zebrafish orthologs corresponding to mammalian SUR1 (zSUR1) and SUR2 (zSUR2) by the genomic database. Both Kir6...
  88. ncbi A novel Val734Ile variant in the ABCC9 gene associated with myocardial infarction
    Piercarlo Minoretti
    Department of Cardiology, Alessandro Manzoni Hospital of Lecco, Lecco, Italy
    Clin Chim Acta 370:124-8. 2006
    ..are deemed to play an important role in myocardial infarction (MI), and the ATP-binding cassette transporter C9-ABCC9-may be involved in the regulation of coronary artery vasomotility...
  89. ncbi Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytes
    H Singh
    Division of Medicine and Therapeutics, University of Leicester, Robert Kilpatrick Building, Leicester Royal Infirmary, LE2 7LX, Leicester, UK
    J Mol Cell Cardiol 35:445-59. 2003
    ..Combinations of these subunits would not explain the reported pharmacology of the mitochondrial K(ATP) channel (Mol Pharmacol 59 (2001) 225) suggesting the possibility of further unidentified components of this channel...
  90. ncbi Glibenclamide-induced apoptosis is specifically enhanced by expression of the sulfonylurea receptor isoform SUR1 but not by expression of SUR2B or the mutant SUR1(M1289T)
    Annette Hambrock
    Department of Pharmacology and Toxicology, Medical Faculty, University of Tubingen, Tubingen, Germany
    J Pharmacol Exp Ther 316:1031-7. 2006
    ..at which a single amino acid in transmembrane helix 17 (TM17) was exchanged by the corresponding amino acid of SUR2. By analyzing cell detachment, nuclear condensation, DNA fragmentation, and caspase-3-like activity, we observed a ..
  91. ncbi A haplotype in the human Sur2 gene is associated with essential hypertension
    N Sato
    Division of Genomic Epidemiology and Clinical Trials, Advanced Medical Research Center, Tokyo, Japan
    J Hum Hypertens 20:87-90. 2006
  92. ncbi Sulphonylurea receptors differently modulate ICC pacemaker Ca2+ activity and smooth muscle contractility
    Shinsuke Nakayama
    Department of Cell Physiology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    J Cell Sci 118:4163-73. 2005
    ..expression of the type 1 isoform of sulphonylurea receptors (SUR1) in ICCs of the mouse ileum, but expression of SUR2 was predominant in smooth muscle...
  93. pmc A Link between ethylene and auxin uncovered by the characterization of two root-specific ethylene-insensitive mutants in Arabidopsis
    Anna N Stepanova
    Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
    Plant Cell 17:2230-42. 2005
    ..Furthermore, wei2 and wei7 suppress the high-auxin phenotypes of superroot1 (sur1) and sur2, two auxin-overproducing mutants, suggesting that the roles of WEI2 and WEI7 in the regulation of auxin ..
  94. pmc Cardiac KATP channels in health and disease
    Garvan C Kane
    Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Mol Cell Cardiol 38:937-43. 2005
    ..findings are underscored by the identification in humans that defective K(ATP) channels induced by mutations in ABCC9, the gene encoding the cardiac sulfonylurea receptor subunit, confer susceptibility to dilated cardiomyopathy...
  95. ncbi Kir1.1 expression in embryonic kidney epithelia
    Gerald S Braun
    Physiologisches Institut, Ludwig Maximilians Universitat, 80336, Munich, Germany
    Biochem Biophys Res Commun 312:1191-5. 2003
    ..We have recently shown a role for an inwardly rectifying K(+) channel, Kir6.1/SUR2(B), in the regulation of cell proliferation during early kidney development...
  96. pmc E1A-CR3 interaction-dependent and -independent functions of mSur2 in viral replication of early region 1A mutants of mouse adenovirus type 1
    Lei Fang
    Department of Microbiology and Immunology, University of Michigan Medical School, 1150 W Medical Center Dr, 6723 Medical Science Bldg II, Ann Arbor, MI 48109 0620, USA
    J Virol 79:3267-76. 2005
    ..At a multiplicity of infection (MOI) of 1, viruses containing CR3 replicated better in Sur2+/+ mouse embryonic fibroblasts (MEFs) than in Sur2-/- MEFs...
  97. ncbi Iptkalim inhibits cocaine challenge-induced enhancement of dopamine levels in nucleus accumbens and striatum of rats by up-regulating Kir6.1 and Kir6.2 mRNA expression
    Yun Liu
    Department of Pharmacology and Neurobiology, Nanjing Medical University, Nanjing 210029, China
    Acta Pharmacol Sin 24:527-33. 2003
    ....
  98. ncbi Effect of two amino acids in TM17 of Sulfonylurea receptor SUR1 on the binding of ATP-sensitive K+ channel modulators
    Annette Hambrock
    Department of Pharmacology and Toxicology, Medical Faculty, University of Tubingen, Wilhelmstrasse 56, D 72074 Tubingen, Germany
    Diabetes 53:S128-34. 2004
    ..SUR isoform, shows much higher affinity for glibenclamide but considerably lower affinity for most openers than SUR2. In radioligand binding assays, we investigated the role of two amino acids, T1285 and M1289, located in ..
  99. ncbi Sulphonylurea action revisited: the post-cloning era
    F M Gribble
    Department of Clinical Biochemistry, Addenbrooke s Hospital, Hills Road, Box 232, Cambridge CB2 2QR, UK
    Diabetologia 46:875-91. 2003
    ..sulphonylurea receptors (SUR1), and the other blocking cardiovascular and skeletal muscle sulphonylurea receptors (SUR2) with potencies similar to their action on SUR1...
  100. ncbi Molecular characterization of a local sulfonylurea system in human adipose tissue
    Britt G Gabrielsson
    Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
    Mol Cell Biochem 258:65-71. 2004
    ..Two different SUR genes (SUR1 and SUR2) and two different Kir6.x genes (Kir6.1 and Kir6.2) have been identified...
  101. ncbi Ras induces mediator complex exchange on C/EBP beta
    Xianming Mo
    Max Delbruck Center for Molecular Medicine, Robert Roessle Str 10, 13092 Berlin, Germany
    Mol Cell 13:241-50. 2004
    ..Active and repressive C/EBPbeta interacts with multisubunit Mediator complexes through the CRSP130/Sur2 subunit...

Research Grants69

  1. Development of HTS Assay:PK(ATP)FLIPR Channels (RMI)
    Xinmin Xie; Fiscal Year: 2005
    ..2 subunits) for primary screening and against the muscle form (e. g. , SUR2/Kir6...
  2. SUR Transmembrane Domain in K(ATP) Channel Function
    Robert Harvey; Fiscal Year: 2006
    ..g. SUR1, SUR2), and (ii) an Inwardly rectifying potassium (j about) channel subunit (Kir6; e.g. Kir6.1, Kir6.2)...
  3. Molecular Regulation of Cardiac KATP Channels in Ischemia
    Jonathan Makielski; Fiscal Year: 2009
    ..The sulfonylurea receptor subunit SUR2 regulates pharmacology and nucleotide interactions for sKATP, but the role of SUR2 in mKATP is unknown...
  4. Molecular Regulation of Cardiac KATP Channels in Ischemia
    Jonathan C Makielski; Fiscal Year: 2010
    ..The sulfonylurea receptor subunit SUR2 regulates pharmacology and nucleotide interactions for sKATP, but the role of SUR2 in mKATP is unknown...
  5. Genetic Markers of GIK Effect in Acute Coronary Syndrome in the IMMEDIATE Trial
    Inga Peter; Fiscal Year: 2009
    ..and IDE), fatty acid metabolism regulation (PRKAA2, PPARA, and PPARG), and potassium channel activity (KCNJ11 and ABCC9) in the heart will be associated with the immediate and long-term response to GIK therapy administered in the ..
  6. Genetic Markers of GIK Effect in Acute Coronary Syndrome in the IMMEDIATE Trial
    Inga Peter; Fiscal Year: 2007
    ..and IDE), fatty acid metabolism regulation (PRKAA2, PPARA, and PPARG), and potassium channel activity (KCNJ11 and ABCC9) in the heart will be associated with the immediate and long-term response to GIK therapy administered in the ..
  7. Sulfonylurea KATP channels in vascular spasm
    Elizabeth McNally; Fiscal Year: 2009
    Potassium ATP (KATP) channels are composed of a sulfonylurea subunit, SUR1 or SUR2, and a pore forming potassium channel, Kir6.1 or Kir6.2...
  8. BIOSYNTHESIS OF ADENOVIRUS EARLY RNA'S
    ARNOLD BERK; Fiscal Year: 2007
    ..region 3 (CR3) as a model activation domain, capitalizing on recent work showing that it activates by binding the Sur2 subunit of the mammalian Mediator complex...
  9. Molecular Regulation - Cardiac KATP Channels in Ischemia
    Jonathan Makielski; Fiscal Year: 2006
    ..The sulfonylurea receptor subunit SUR2 regulates pharmacology and nucleotide interactions for surface KATP, but the molecular nature of the subunit for ..
  10. Role of Kir6.1 subunits of K+ channels in heart
    WILLIAM COETZEE; Fiscal Year: 2004
    ..1 and Kir6.2) - both are highly expressed in heart. Cardiac KATP channels are believed to consist of Kir6.2/SUR2 complexes. However, the role of Kir6.1 is unknown...
  11. MOLECULAR REGULATION--CARDIAC K+ATP CHANNELS IN ISCHEMIA
    Jonathan Makielski; Fiscal Year: 2001
    ..Investigators on native cardiac KATP, by the recent availability of KATP clones (co- expressed BIR/SUR1 and KATP/SUR2), and by a structural hypothesis of phospholipid effects involving the cytoplasmic C-tail of the KATP...
  12. Phosphoinositides and ATP-sensitive K+ channels in heart
    Zheng Fan; Fiscal Year: 2005
    ..2 association modulates ATP binding. (3) We will investigate the role of SUR2, the regulatory subunit of the KATPchannel, in PPI-KATP channel interaction and PPI modulation of ATP binding...
  13. Mapping Novel Disease Genes for Dilated Cardiomyopathy
    TIMOTHY MARK OLSON; Fiscal Year: 2010
    ..Discovering the genetic basis of DCM will lead to better ways to diagnose and prevent the progressive weakening of heart muscle that afflicts patients with this disorder. ..
  14. Identification of Disease Genes for Atrial Fibrillation
    Timothy Olson; Fiscal Year: 2009
    ..The long-term objectives of this work are to gain new insights into molecular mechanisms of arrhythmogenesis and to improve prediction, prevention, and treatment of AF. ..
  15. Mapping Novel Disease Genes for Dilated Cardiomyopathy
    Timothy Olson; Fiscal Year: 2007
    ..Discovering the genetic basis of DCM will lead to better ways to diagnose and prevent the progressive weakening of heart muscle that afflicts patients with this disorder. ..
  16. Mapping Novel Disease Genes for Dilated Cardiomyopathy
    Timothy Olson; Fiscal Year: 2004
    ..The long-term objectives of this work are to gain new insights into molecular mechanisms for heart failure and to improve prediction, prevention, and treatment of DCM. ..
  17. Identification of Disease Genes for Atrial Fibrillation
    Timothy Olson; Fiscal Year: 2007
    ..The long-term objectives of this work are to gain new insights into molecular mechanisms of arrhythmogenesis and to improve prediction, prevention, and treatment of AF. ..
  18. SUR1 (ABCC8) AND ATRIAL KATP CHANNELS
    Colin Nichols; Fiscal Year: 2009
    ....
  19. Sulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic stroke
    J Marc Simard; Fiscal Year: 2007
    ..End of Abstract) ..
  20. PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELS
    J Simard; Fiscal Year: 2004
    ....
  21. Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subara
    J Marc Simard; Fiscal Year: 2010
    ..In this proposal, we will use a rat model of SAH to establish the essential role of the NC(Ca-ATP) channel in pathophysiology post-SAH. ..
  22. Cloning a major gene for mouse adenovirus susceptibility
    Katherine R Spindler; Fiscal Year: 2010
    ..The project is expected to identify a previously undescribed intractiorT^ieT^eerrK6sfiTrTrmrne res immune evasion, thus increasing our understanding of viral infections and mechanisms of host response to pathogens. ~ ..
  23. Cloning a major gene for mouse adenovirus susceptibility
    KATHERINE SPINDLER; Fiscal Year: 2007
    ..The project is expected to identify a previously undescribed interaction between host immune response and viral immune evasion, thus increasing our understanding of viral infections and mechanisms of host response to pathogens. ..
  24. Sulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic stroke
    J Marc Simard; Fiscal Year: 2009
    ..End of Abstract) ..
  25. Spinal cord injury, progressive hemorrhagic necrosis and the NC(Ca-ATP) channel
    J Marc Simard; Fiscal Year: 2009
    ..These studies will form the basis for novel future therapies for spinal cord injury. ..