Genomes and Genes
Gene Symbol: ABCC9
Description: ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Alias: ABC37, ATFB12, CANTU, CMD1O, SUR2, ATP-binding cassette sub-family C member 9, ATP-binding cassette transporter sub-family C member 9, sulfonylurea receptor 2
Publications116 found, 100 shown here
- Effects of ATP-sensitive potassium channels on the expression of P21, P27 and leptinYaohui Wang
Department of Pathophysiology, Zunyi Medical College, Zunyi, China
J Huazhong Univ Sci Technolog Med Sci 29:8-11. 2009..The results showed that the expression of SUR2, not SUR1 was detected in adipose tissue, preadipocytes and adipocytes...
- A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channelsN Inagaki
Division of Molecular Medicine Center for Biomedical Science, Chiba University School of Medicine, Chuo Ku, Chiba 260, Japan
Neuron 16:1011-7. 1996We have cloned an isoform of the sulfonylurea receptor (SUR), designated SUR2. Coexpression of SUR2 and the inward rectifier K+ channel subunit Kir6...
- Toward understanding the assembly and structure of KATP channelsL Aguilar-Bryan
Department of Cell Biology, Baylor College of Medicine, Houston, Texas, USA
Physiol Rev 78:227-45. 1998..The availability of cloned KATP channel genes opens the way for characterization of this family of ion channels and identification of additional genetic defects...
- ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gatingMartin Bienengraeber
Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Mayo Foundation, Rochester, Minnesota 55905, USA
Nat Genet 36:382-7. 2004..with heart failure and rhythm disturbances due to idiopathic dilated cardiomyopathy identified two mutations in ABCC9, which encodes the regulatory SUR2A subunit of the cardiac K(ATP) channel...
- Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channelsW A Chutkow
Department of Medicine, Howard Hughes Medical Institute, Chicago, Illinois, USA
Diabetes 45:1439-45. 1996..Northern blotting showed that the highest expression of the SUR2 isoforms is in the heart and skeletal muscle, with lower levels in all other tissues...
- Physical association between recombinant cardiac ATP-sensitive K+ channel subunits Kir6.2 and SUR2AE Lorenz
Department of Internal Medicine, Mayo Clinic, Mayo Foundation, Rochester, Minnesota 55905, USA
J Mol Cell Cardiol 31:425-34. 1999..The demonstration of complex formation between Kir6.2 and SUR2A indicates that the structural basis for channel function may rely on direct physical interaction of the two subunits...
- Patents related to therapeutic activation of K(ATP) and K(2P) potassium channels for neuroprotection: ischemic/hypoxic/anoxic injury and general anestheticsSusan I V Judge
University of Maryland School of Medicine, MS Center of Excellence East, VA Maryland Health Care System, Department of Neurology, BRB 12 040, 655 West Baltimore Street, Baltimore, MD 21201, USA
Expert Opin Ther Pat 19:433-60. 2009..which belong to the family of inwardly rectifying K(+) channels (K(ir)) and contain a sulfonylurea subunit (SUR1 or SUR2) combined with either K(ir)6.1 (KCNJ8) or K(ir)6...
- Molecular mechanisms underlying ketamine-mediated inhibition of sarcolemmal adenosine triphosphate-sensitive potassium channelsTakashi Kawano
Department of Anesthesiology, Tokushima University School of Medicine, Tokushima, Japan
Anesthesiology 102:93-101. 2005..1 or Kir6.2) and sulfonylurea receptors (SUR1, SUR2A, or SUR2B)...
- Substrates and inhibitors of human multidrug resistance associated proteins and the implications in drug developmentShu Feng Zhou
Division of Chinese Medicine, School of Health Sciences, WHO Collaborating Center for Traditional Medicine, RMIT University, Victoria, Australia
Curr Med Chem 15:1981-2039. 2008..ABCC7 is cystic fibrosis transmembrane conductance regulator; ABCC8 and ABCC9 are the sulfonylurea receptors which constitute the ATP-sensing subunits of a complex potassium channel...
- Differential K(ATP) channel pharmacology in intact mouse heartAlexey V Glukhov
Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
J Mol Cell Cardiol 48:152-60. 2010Classically, cardiac sarcolemmal K(ATP) channels have been thought to be composed of Kir6.2 (KCNJ11) and SUR2A (ABCC9) subunits...
- Phosphoinositides decrease ATP sensitivity of the cardiac ATP-sensitive K(+) channel. A molecular probe for the mechanism of ATP-sensitive inhibitionZ Fan
Department of Physiology, University of Tennessee, College of Medicine, Memphis, Tennessee 38163, USA
J Gen Physiol 114:251-69. 1999..clamp technique in cardiac myocytes and in COS-1 cells in which the cardiac isoform of the sulfonylurea receptor, SUR2, was coexpressed with the inwardly rectifying channel Kir6.2...
- Proximal C-terminal domain of sulphonylurea receptor 2A interacts with pore-forming Kir6 subunits in KATP channelsRichard D Rainbow
Department of Cell Physiology and Pharmacology, University of Leicester, University Road, Leicester LE1 9HN, UK
Biochem J 379:173-81. 2004..ATP- and glibenclamide-sensitive K+ currents were decreased in HEK-293 cells expressing full-length Kir6 and SUR2 subunits that were transiently transfected with fragments rSUR2A-CTA, rSUR2A-CTC and rSUR2A-CTE (residues 1294-1359)..
- Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarctionShigeo Horinaka
Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, 880 Kitakobayashi, Mibu, Tochigi, 321 0293, Japan
Cardiovasc Drugs Ther 18:13-22. 2004..At 24 hours after treatment, eNOS, iNOS, and SUR2 mRNA levels and eNOS, iNOS expression in the left ventricle were determined by reverse transcription polymerase ..
- Glucose-receptive neurones in the rat ventromedial hypothalamus express KATP channels composed of Kir6.1 and SUR1 subunitsK Lee
Parke Davis Neuroscience Research Centre, Cambridge University Forvie Site, Cambridge CB2 2QB, UK
J Physiol 515:439-52. 1999..1 and SUR1 but not Kir6.2 or SUR2. 6...
- Coassembly of different sulfonylurea receptor subtypes extends the phenotypic diversity of ATP-sensitive potassium (KATP) channelsAdam Wheeler
Department of Physiology and Biophysics, Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
Mol Pharmacol 74:1333-44. 2008..SUR1- but not SUR2-containing channels are highly sensitive to metabolic inhibition and diazoxide, whereas SUR2 channels are sensitive ..
- Topology mapping of the amino-terminal half of multidrug resistance-associated protein by epitope insertion and immunofluorescenceC Kast
Department of Biochemistry, McGill University, Montreal, Quebec H3G 1Y6, Canada
J Biol Chem 272:26479-87. 1997..cadmium factor 1 and yeast oligomycin resistance I proteins, and the mammalian sulfonylurea receptors SUR1 and SUR2. Hydropathy analysis of these proteins predicts a unique membrane-associated region at the amino terminus followed ..
- Sesquiterpenoids from antidiabetic Psacalium decompositum block ATP sensitive potassium channelsMaria G Campos
Unit of Medical Research in Pharmacology, National Medical Center SXXI, IMSS, Mexico, Mexico
J Ethnopharmacol 123:489-93. 2009....
- Spontaneous coronary vasospasm in KATP mutant mice arises from a smooth muscle-extrinsic processRahul Kakkar
Department of Medicine, The University of Chicago, IL 60637, USA
Circ Res 98:682-9. 2006..Two transgenic founder lines were generated and independently bred to sulfonylurea receptor 2 (SUR2) null mice to generate mice that restored expression of KATP channels in vascular smooth muscle...
- Suppressed Ca2+/CaM/CaMKII-dependent K(ATP) channel activity in primary afferent neurons mediates hyperalgesia after axotomyTakashi Kawano
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Proc Natl Acad Sci U S A 106:8725-30. 2009..Immunohistochemistry identified the presence of K(ATP) channel subunits SUR1, SUR2, and Kir6.2 but not Kir6.1, and pCaMKII in neurofilament 200-positive DRG somata...
- The molecular basis of the specificity of action of K(ATP) channel openersC Moreau
CEA, DBMS, Biophysique Moléculaire et Cellulaire UMR CNRS UJF CEA 5090, 17 rue des Martyrs, 38054 Grenoble, France
EMBO J 19:6644-51. 2000..g. pinacidil, cromakalim, nicorandil) act specifically on the SUR2 muscle isoforms but, except for diazoxide, remain ineffective on the SUR1 neuronal/pancreatic isoform...
- Stoichiometry of sulfonylurea-induced ATP-sensitive potassium channel closureH Dorschner
Institut fur Pharmakologie und Toxikologie, Universität Braunschweig, Mendelssohnstrabetae 1, 38106 Braunschweig, Germany
Mol Pharmacol 55:1060-6. 1999..Affinities of sulfonylureas for rat SUR2A, rat or human SUR2B, and a SUR2 chimera containing the C-terminal 42 amino acids of SUR1 did not differ significantly, implying that the C terminus ..
- Involvement of ATP-sensitive potassium channels in proliferation and differentiation of rat preadipocytesYao Hui Wang
Department of Pathophysiology, Huazhong University of Science and Technology, Wuhan 430030, China
Sheng Li Xue Bao 59:8-12. 2007..We examined the expression of sulphonylurea receptor 2 (SUR2) mRNA in preadipocytes and adipocytes obtained by inducing for 5 d and the effects of the inhibitor (glibenclamide) ..
- Molecular identification and functional characterization of a mitochondrial sulfonylurea receptor 2 splice variant generated by intraexonic splicingBin Ye
Department of Medicine, University of Wisconsin, Madison, WI 53706, USA
Circ Res 105:1083-93. 2009..Cardioprotective pathways may involve a mitochondrial ATP-sensitive potassium (mitoK(ATP)) channel but its composition is not fully understood...
- Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in ratS Horinaka
Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Tochigi, Japan
J Cardiovasc Pharmacol 38:200-10. 2001..e., an ATP-binding cassette protein sulfonylurea receptor (SUR2) and a pore-forming inward rectifier (Kir6.1 or 6.2)...
- Human hair follicles contain two forms of ATP-sensitive potassium channels, only one of which is sensitive to minoxidilKatie Shorter
Department of Biomedical Sciences, University of Bradford, Bradford, BD7 1DP, UK
FASEB J 22:1725-36. 2008..2/SUR1 and Kir6.1/SUR2B; minoxidil only stimulates SUR2 channels...
- K(ATP) channel openers protect mesencephalic neurons against MPP+-induced cytotoxicity via inhibition of ROS productionJuan Xie
Jiangsu Key Laboratory of Neurodegeneration, Department of Pharmacology, Nanjing Medical University, Nanjing, Jiangsu, People s Republic of China
J Neurosci Res 88:428-37. 2010..However, cromakalim (Cro), an opener of Kir6.1/SUR2 but not Kir6.2/SUR1 K(ATP) channels, failed to protect against MPP(+)-induced cytotoxicity...
- Iptakalim protects against hypoxic brain injury through multiple pathways associated with ATP-sensitive potassium channelsH L Zhu
Department of Environmental Medicine, Tianjin Institute of Hygiene and Environmental Medicine, Tianjin 300050, China
Neuroscience 157:884-94. 2008..In this study, adult Wistar rats were treated with iptakalim, a new KATP channel opener, which is selective for SUR2 type KATP channels, by intragastric administration at doses of 2, 4, or 8 mg/kg/day for 7 days before being exposed ..
- Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteinsRoger G Deeley
Division of Cancer Biology and Genetics, Cancer Research Institute and Department of Biochemistry, Queen s University Kingdom, Ontario, Canada
Physiol Rev 86:849-99. 2006..with the cystic fibrosis conductance regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) comprise the 13 members of the human "C" branch of the ATP binding cassette (ABC) superfamily...
- Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblastsNajate Benamer
Institut de Physiologie et Biologie Cellulaires, CNRS UMR 6187, Universite de Poitiers, France
J Mol Cell Cardiol 46:508-17. 2009..Among potassium channel transcripts which were screened by high-throughput real-time PCR, SUR2 and Kir6.1 mRNAs were found to be the most abundant in ventricular fibroblasts...
- [Molecular and functional diversity of ATP-sensitive K+ channels: the pathophysiological roles and potential drug targets]Haruaki Nakaya
Department of Pharmacology, Chiba University Graduate School of Medicine, Japan
Nihon Yakurigaku Zasshi 122:243-50. 2003..1 or Kir6.2) and the regulatory subunit sulfonylurea receptors (SUR1 or SUR2)...
- Identification of an ATP-sensitive potassium channel current in rat striatal cholinergic interneuronesK Lee
Parke Davis Neuroscience Research Centre, Cambridge University Forvie Site, UK
J Physiol 510:441-53. 1998..1 and SUR1 but not Kir6.2 or SUR2. 6...
- A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channelS Isomoto
Department of Pharmacology II, Faculty of Medicine, Osaka University, 2 2 Yamadaoka, Suita, Osaka 565, Japan
J Biol Chem 271:24321-4. 1996..Sequence analysis indicated that this clone is a variant of cardiac type sulfonylurea receptor (SUR2)...
- KATP channel subunits are expressed in the epididymal epithelium in several mammalian speciesPascale Lybaert
Laboratory of Experimental Hormonology, Faculty of Medicine, Universite Libre de Bruxelles ULB, B 1070 Brussels, Belgium
Biol Reprod 79:253-61. 2008..A positive immunostaining for Kir6.2 (KCNJ11) and SUR2 (ABCC9) was observed by immunoenzymatic and immunofluorescent approaches in the principal epithelial cells throughout all ..
- Metabolomic, transcriptional, hormonal, and signaling cross-talk in superroot2Marc Morant
Plant Biochemistry Laboratory, Department of Plant Biology and Biotechnology, University of Copenhagen, 40 Thorvaldsensvej, Frederiksberg C, Copenhagen, Denmark
Mol Plant 3:192-211. 2010Auxin homeostasis is pivotal for normal plant growth and development. The superroot2 (sur2) mutant was initially isolated in a forward genetic screen for auxin overproducers, and SUR2 was suggested to control auxin conjugation and thereby ..
- The role of survivin2 in primitive hematopoiesis during zebrafish developmentA C H Ma
Division of Haematology and Bone Marrow Transplantation, Department of Medicine, Queen Mary Hospital, University of Hong Kong, Hong Kong, China
Leukemia 23:712-20. 2009..In this study, we examined survivin2 (sur2) with particular reference to its role in primitive hematopoiesis during zebrafish development...
- Identification of two Mycobacterium tuberculosis H37Rv ORFs involved in resistance to killing by human macrophagesB H Miller
Department of Microbiology and Immunology, Emory University School of Medicine and Division of AIDS, STD, and TB Laboratory Research, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
BMC Microbiol 1:26. 2001..tuberculosis H37Rv genomic DNA, was passed through THP-1 human macrophages three times...
- Mice lacking sulfonylurea receptor 2 (SUR2) ATP-sensitive potassium channels are resistant to acute cardiovascular stressDouglas Stoller
Committee on Cell Physiology, The University of Chicago, Chicago, IL 60637, USA
J Mol Cell Cardiol 43:445-54. 2007..Cardiomyocyte K(ATP) channels are composed of the pore-forming Kir6.2 subunit and the regulatory sulfonylurea receptor 2 (SUR2)...
- Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytesCecilia Bondjers
Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden
FASEB J 20:1703-5. 2006..1 (also known as Kcnj8) and sulfonylurea receptor 2, (SUR2, also known as Abcc9), both part of the same channel complex, as well as delta homologue 1 (DLK1) ..
- Impaired exercise tolerance and skeletal muscle myopathy in sulfonylurea receptor-2 mutant miceDouglas Stoller
Committee on Cellular and Molecular Physiology, The University of Chicago, Chicago, Illinois 60637, USA
Am J Physiol Regul Integr Comp Physiol 297:R1144-53. 2009..b>SUR2 mutant mice lack full-length K(ATP) channels in striated and smooth muscle and display a complex phenotype of ..
- Post-infarction treatment with simvastatin reduces myocardial no-reflow by opening of the KATP channelYue jin Yang
Department of Cardiology, Cardiovascular Institute and Fu Wai Heart Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Bei Li Shi Road 167, West City District, Beijing, 100037, China
Eur J Heart Fail 9:30-6. 2007..However, it remains unknown whether post-infarction treatment with simvastatin can also reduce myocardial no-reflow for which suppression of adenosine triphosphate-sensitive K+ (K(ATP)) channel opening is an important mechanism...
- Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunitJennitte L Stevens
Molecular Biology Institute, University of California, Los Angeles, 611 Charles Young Drive East, Los Angeles, CA 90095, USA
Science 296:755-8. 2002b>Sur2 is a metazoan Mediator subunit that interacts with the adenovirus E1A protein and functions in a mitogen-activated protein kinase pathway required for vulva development in Caenorhabditis elegans...
- ATP-sensitive potassium currents in rat primary afferent neurons: biophysical, pharmacological properties, and alterations by painful nerve injuryT Kawano
Department of Anesthesiology, Anesthesia Research MEB, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Neuroscience 162:431-43. 2009..Using specific antibodies, we identified SUR1, SUR2, and Kir6.2 but not Kir6.1 subunits in DRGs...
- Morphological localisation of sulfonylurea receptor 1 in endocrine cells of human, mouse and rat pancreasY Guiot
Department of Pathology, Faculty of Medicine, University of Louvain, B 1200, Brussels, Belgium
Diabetologia 50:1889-99. 2007..Morphological methods (immunohistochemistry and sulfonylurea binding) were used to establish the cellular and subcellular location of SUR1 in human and rodent islets...
- ABCC8 and ABCC9: ABC transporters that regulate K+ channelsJoseph Bryan
Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA
Pflugers Arch 453:703-18. 2007The sulfonylurea receptors (SURs) ABCC8/SUR1 and ABCC9/SUR2 are members of the C-branch of the transport adenosine triphosphatase superfamily...
- Effects of Abeta1-42 on the subunits of KATP expression in cultured primary rat basal forebrain neuronsGuozhao Ma
Department of Neurology, Provincial Hospital affiliated to Shandong University, No 324 Jingwu Weiqi Road, Jinan 250021, Shandong, PR China
Neurochem Res 33:1419-24. 2008..The subunits of KATP: Kir6.1, Kir6.2, SUR1 and SUR2 expressing changes were observed by double immunofluorescence and immunoblotting when the neurons were exposed to ..
- Localization of the sulphonylurea receptor subunits, SUR2A and SUR2B, in rat renal tubular epitheliumMing Zhou
Department of Anatomy, Akita University School of Medicine
Tohoku J Exp Med 214:247-56. 2008..The SURs are divided into two isoforms, SUR1 and SUR2, the latter was further divided into SUR2A and SUR2B...
- Ontogeny of sulfonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometriumN Lovasz
Department of Pharmacodynamics and Biopharmacy, Faculty of Pharmacy, University of Szeged, Szeged, Hungary
Reproduction 142:175-81. 2011..to examine the expression and role of sulfonylurea-binding regulatory subunits 1 (SUR1 (ABCC8)) and 2 (SUR2 (ABCC9)) of the K(ATP) channels in the pregnant rat myometrium with particular regard to the contractility...
- Sulfonylurea receptors type 1 and 2A randomly assemble to form heteromeric KATP channels of mixed subunit compositionKim W Chan
Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106, USA
J Gen Physiol 131:43-58. 2008..The reported expression of both SUR1 and SUR2 together with Kir6...
- Kir1.1 expression in embryonic kidney epitheliaGerald S Braun
Physiologisches Institut, Ludwig Maximilians Universitat, 80336, Munich, Germany
Biochem Biophys Res Commun 312:1191-5. 2003..We have recently shown a role for an inwardly rectifying K(+) channel, Kir6.1/SUR2(B), in the regulation of cell proliferation during early kidney development...
- Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null miceAdebowale Adebiyi
Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, USA
Am J Physiol Heart Circ Physiol 301:H1360-8. 2011..In the present study, we used a genetic model to investigate the physiological functions of SUR2-containing K(ATP) channels in mediating vasodilation to hypoxia, oxygen and glucose deprivation (OGD) or metabolic ..
- Characterization of an ATP-sensitive K(+) channel in rat carotid body glomus cellsDonghee Kim
Department of Physiology and Biophysics, Rosalind Franklin University of Medicine and Science, The Chicago Medical School, 3333 Green Bay Road, North Chicago, IL 60064, United States
Respir Physiol Neurobiol 177:247-55. 2011..Reverse transcriptase-PCR and immunocytochemistry showed that Kir6.1, Kir6.2, SUR1 and SUR2 were expressed in CB glomus cells as well as in non-glomus cells...
- ATP-sensitive potassium channel: a novel target for protection against UV-induced human skin cell damageCong Cao
Department of Biology, Providence College, Providence, Rhode Island 02918, USA
J Cell Physiol 212:252-63. 2007..Here, we demonstrated for the first time that Kir 6.1, Kir 6.2 and SUR2 subunits of K(ATP) channels are functionally expressed in HaCaT cells and both non-selective K(ATP) channel opener ..
- Sulfonylurea receptor-dependent and -independent pathways mediate vasodilation induced by ATP-sensitive K+ channel openersAdebowale Adebiyi
Department of Physiology, University of Tennessee Health Science Center, Memphis, TN 38163, USA
Mol Pharmacol 74:736-43. 2008..mechanisms by which diazoxide and pinacidil induce vasodilation by studying diameter regulation of wild-type [SUR2(+/+)] and sulfonylurea receptor (SUR) 2-deficient [SUR2(-/-)] mouse myogenic mesenteric arteries...
- Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channelsGuo Hua Liang
Dept of Physiology, Univ of Tennessee Health Science Ctr, Memphis, TN 38163, USA
Am J Physiol Heart Circ Physiol 300:H2088-95. 2011..also studied in pressurized resistance-size cerebral arteries of mice with a genetic deletion in the gene encoding SUR2 (SUR2 null)...
- Diazoxide reverses the enhanced expression of KATP subunits in cholinergic neurons caused by exposure to Aβ₁₋₄₂Guozhao Ma
Department of Neurology, Provincial Hospital affiliated to Shandong University, No 324 Jingwu Weiqi Road, 250021 Jinan, Shandong, People s Republic of China
Neurochem Res 34:2133-40. 2009..The subunits of KATP: Kir6.1, Kir6.2, SUR1 and SUR2 expressing change was observed by double Immunofluorescence and immunoblotting in cultured cholinergic neurons from ..
- Gene expression profiling of ABC transporters in dermal fibroblasts of pseudoxanthoma elasticum patients identifies new candidates involved in PXE pathogenesisDoris Hendig
Institut fur Laboratoriums und Transfusionsmedizin, Herz und Diabeteszentrum Nordrhein Westfalen, Universitatsklinik der Ruhr Universitat Bochum, Bad Oeynhausen, Germany
Lab Invest 88:1303-15. 2008..Seven genes (ABCA6, ABCA9, ABCA10, ABCB5, ABCC2, ABCC9 and ABCD2) were induced, whereas the gene expression of one gene (ABCA3) was decreased, comparing controls and PXE ..
- Genes controlling postural changes in blood pressure: comprehensive association analysis of ATP-sensitive potassium channel genes KCNJ8 and ABCC9Justine A Ellis
Department of Physiology, University of Melbourne, Melbourne, Victoria, Australia
Physiol Genomics 40:184-8. 2010..genomewide linkage analysis suggests a region on chromosome 12p that harbors two strong candidate genes, KCNJ8 and ABCC9, encoding the channel-forming inward rectifier subunit Kir6...
- Opening of microglial K(ATP) channels inhibits rotenone-induced neuroinflammationFang Zhou
Jiangsu Key Laboratory of Neurodegeneration, Department of Anatomy Histology, Pharmacology Nanjing Medical University Nanjing, Jiangsu, P R China
J Cell Mol Med 12:1559-70. 2008..The present study demonstrates that rat primary cultured MG expressed Kir6.1 and SUR2 subunits of K(ATP) channel, which was identical to that expressed in BV-2 microglial cell line...
- KATP channel subunits in rat dorsal root ganglia: alterations by painful axotomyVasiliki Zoga
Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
Mol Pain 6:6. 2010....
- A novel custom resequencing array for dilated cardiomyopathyRebekah S Zimmerman
Laboratory for Molecular Medicine, Partners Healthcare Center for Personalized Genetic Medicine, Cambridge, Massachusetts 02139, USA
Genet Med 12:268-78. 2010..Novel sequencing platforms have now opened up avenues for more comprehensive diagnostic testing while simultaneously decreasing test cost and turn around time...
- Effect of propofol on cardiac function and gene expression after ischemic-reperfusion in isolated rat heartYoun Jin Kim
Department of Anesthesiology and Pain Medicine, School of Medicine, Ewha Womans University, Seoul, Korea
Korean J Anesthesiol 58:153-61. 2010..The aim of this study was to examine the cardiac function and transcriptional response of the heart to propofol after ischemia-reperfusion...
- Gender-related differences in ion-channel and transporter subunit expression in non-diseased human heartsNathalie Gaborit
INSERM, UMR915, l institut du thorax, Nantes, France
J Mol Cell Cardiol 49:639-46. 2010..3, Kv1.4, KChIP2, SUR2 and Kir6.2, as well as lower expression of connexin43 and phospholamban...
- Syntaxin-1A inhibition of P-1075, cromakalim, and diazoxide actions on mouse cardiac ATP-sensitive potassium channelBetty Ng
Department of Medicine, University of Toronto, Room 7310, Medical Sciences Building, Toronto, ON, Canada
Cardiovasc Res 80:365-74. 2008..Here, we examined whether Syn-1A would influence non-specific (diazoxide) and SUR2-specific KCOs [N-cyano-N'-(1,1-dimethylpropyl)-N''-3-pyridylguanidine (P-1075) and cromakalim] on cardiac myocyte K(..
- Cardiomyocyte sulfonylurea receptor 2-KATP channel mediates cardioprotection and ST segment elevationDouglas A Stoller
Committee on Cellular and Molecular Physiology, University of Chicago, Chicago, IL 60637, USA
Am J Physiol Heart Circ Physiol 299:H1100-8. 2010..Mice deleted for the first nucleotide binding region of sulfonylurea receptor 2 (SUR2) are referred to as SUR2 null since they lack full-length SUR2 and glibenclamide-responsive K(ATP) ..
- Human oocytes express ATP-sensitive K(+) channelsQingyou Du
Division of Medical Sciences MACHS, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK
Hum Reprod 25:2774-82. 2010..x (Kir6.1 or Kir6.2) and regulatory, SURx (SUR2A, SUR2B or SUR1), subunits that associate in different combinations. The objective of this study was to determine whether mammalian oocytes (human, bovine, porcine) express K(ATP) channels...
- Cardiac sarcolemmal K(ATP) channels: Latest twists in a questing tale!Haixia Zhang
Department of Cell Biology and Physiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
J Mol Cell Cardiol 48:71-5. 2010..1, KCNJ8, and Kir6.2 KCNJ11) with sulfonylurea receptors (SUR1, ABCC8, and SUR2, ABCC9) of the ABCC protein sub-family, has led to the elucidation of many details of channel gating and pore properties, ..
- Random assembly of SUR subunits in K(ATP) channel complexesWayland W L Cheng
Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Channels (Austin) 2:34-8. 2008Sulfonylurea receptors (SURs) associate with Kir6.x subunits to form tetradimeric K(ATP) channel complexes. SUR1 and SUR2 confer differential channel sensitivities to nucleotides and pharmacological agents, and are expressed in specific, ..
- Levcromakalim and MgGDP activate small conductance ATP-sensitive K+ channels of K+ channel pore 6.1/sulfonylurea receptor 2A in pig detrusor smooth muscle cells: uncoupling of cAMP signal pathwaysShunichi Kajioka
University Department of Pharmacology, Oxford, United Kingdom
J Pharmacol Exp Ther 327:114-23. 2008..The 12 pS K(+) channel activated by levcromakalim in pig detrusor smooth muscle cells is a K(ATP) channel. The predominant expression of SUR2A can account for the lack of effect of neurotransmitters related to cAMP...
- SUR2 subtype (A and B)-dependent differential activation of the cloned ATP-sensitive K+ channels by pinacidil and nicorandilT Shindo
Department of Pharmacology II, Faculty of Medicine, Osaka University, Suita, Japan
Br J Pharmacol 124:985-91. 1998....
- Sulphonylurea action revisited: the post-cloning eraF M Gribble
Department of Clinical Biochemistry, Addenbrooke s Hospital, Hills Road, Box 232, Cambridge CB2 2QR, UK
Diabetologia 46:875-91. 2003..sulphonylurea receptors (SUR1), and the other blocking cardiovascular and skeletal muscle sulphonylurea receptors (SUR2) with potencies similar to their action on SUR1...
- Iptkalim inhibits cocaine challenge-induced enhancement of dopamine levels in nucleus accumbens and striatum of rats by up-regulating Kir6.1 and Kir6.2 mRNA expressionYun Liu
Department of Pharmacology and Neurobiology, Nanjing Medical University, Nanjing 210029, China
Acta Pharmacol Sin 24:527-33. 2003....
- Distribution of Kir6.0 and SUR2 ATP-sensitive potassium channel subunits in isolated ventricular myocytesH Singh
Division of Medicine and Therapeutics, University of Leicester, Robert Kilpatrick Building, Leicester Royal Infirmary, LE2 7LX, Leicester, UK
J Mol Cell Cardiol 35:445-59. 2003..Combinations of these subunits would not explain the reported pharmacology of the mitochondrial K(ATP) channel (Mol Pharmacol 59 (2001) 225) suggesting the possibility of further unidentified components of this channel...
- The HAT2 gene, a member of the HD-Zip gene family, isolated as an auxin inducible gene by DNA microarray screening, affects auxin response in ArabidopsisShinichiro Sawa
Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 7 3 1, Hongo, Tokyo 113 0033, Japan
Plant J 32:1011-22. 2002..which are characteristic of the phenotypes of the auxin-overproducing mutants, superroot1 (sur1) and superroot2 (sur2)...
- Rvs161p and sphingolipids are required for actin repolarization following salt stressAxelle Balguerie
Institut de Biochimie et Génétique Cellulaires, CNRS UMR 5095, F 33077 Bordeaux cedex, France
Eukaryot Cell 1:1021-31. 2002..the rvs161delta-related salt sensitivity all occurred in genes required for sphingolipid biosynthesis: FEN1, SUR4, SUR2, SUR1, and IPT1...
- Developmental expression and functional significance of Kir channel subunits in ureteric bud and nephron epitheliaGerald S Braun
Physiologisches Institut, Ludwig Maximilians Universitat, 80336 Munich, Germany
Pflugers Arch 445:321-30. 2002..mRNAs of the vascular-type K(ATP) (K(NDP)) channel-forming subunits Kir6.1/SUR2 were highly expressed in early ureteric bud generations (embryonic day E14) and downregulated thereafter, while ..
- Identification of a transcriptionally active peroxisome proliferator-activated receptor alpha -interacting cofactor complex in rat liver and characterization of PRIC285 as a coactivatorSailesh Surapureddi
Department of Pathology, Northwestern University, The Feinberg School of Medicine, Chicago, IL 60611, USA
Proc Natl Acad Sci U S A 99:11836-41. 2002..The composition of this complex may provide insight into the basis of tissue and species sensitivity to peroxisome proliferators...
- Novel insulin/GIP co-producing cell lines provide unexpected insights into Gut K-cell function in vivoErin B Ramshur
Department of Internal Medicine, Division of Metabolism, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Cell Physiol 192:339-50. 2002..The K-cell lines also express relatively low levels of Kir 6.1, Kir 6.2, SUR1, and SUR2 suggesting secretion is independent of K(ATP) channels...
- Putative subunits of the rat mesangial KATP: a type 2B sulfonylurea receptor and an inwardly rectifying K+ channelBalazs Szamosfalvi
Department of Medicine, Division of Nephrology and Hypertension, Henry Ford Hospital, Detroit, Michigan 48202, USA
Kidney Int 61:1739-49. 2002..Because these responses likely resulted from the binding of sulfonylurea to a mesangial SUR2, we subsequently documented [3H]-glibenclamide binding to MC and the gene expression of several mesangial SUR2 ..
- Yeast mutants affected in viability upon starvation have a modified phospholipid compositionL Desfarges
Laboratoire de Genetique, Talence, France
Yeast 9:267-77. 1993..Ten mutants were obtained, ranged amongst four complementation groups, named SUR1, SUR2, SUR3 and SUR4...
- Disruption of Sur2-containing K(ATP) channels enhances insulin-stimulated glucose uptake in skeletal muscleW A Chutkow
Department of Medicine, University of Chicago, Chicago, IL 60637, USA
Proc Natl Acad Sci U S A 98:11760-4. 2001..used a gene-targeting strategy to generate mice with a disruption in the muscle-specific K(ATP) regulatory subunit, SUR2. Insertional mutagenesis of the Sur2 locus generated homozygous null (Sur2(-/-)) mice and heterozygote (Sur2(+/-)) ..
- Susceptibility of ATP-sensitive K+ channels to cell stress through mediation of phosphoinositides as examined by photoirradiationZ Fan
The Department of Physiology, University of Tennessee, College of Medicine, Memphis, TN 38163, USA
J Physiol 529:707-21. 2000..were recorded from cell-attached and inside-out patches of rat ventricular myocytes and COS-1 cells coexpressing SUR2 and Kir6.2. KATP channel activity increased within < 1 min upon irradiation...
- Accumulation of phosphorylated sphingoid long chain bases results in cell growth inhibition in Saccharomyces cerevisiaeS Kim
Children s Hospital Oakland Research Institute, Oakland, California 94609, USA
Genetics 156:1519-29. 2000..the biological roles of these molecules, we created disruption mutants for LCB4, LCB5, DPL1, YSR2, YSR3, and SUR2. LCB4 and LCB5 encode kinases that phosphorylate long chain bases...
- Molecular characterization of human SUR2-containing K(ATP) channelsR Davis-Taber
Neurological and Urological Diseases Research, Dept 47C, APgA, Abbott Laboratories, 100 Abbott Park Road, Abbott Park, IL 60064, USA
Gene 256:261-70. 2000The distribution of human sulfonylurea receptor-2 (SUR2)-containing K(ATP) channels was investigated using reverse transcriptase-polymerase chain reaction (RT-PCR)...
- The properties of the Kir6.1-6.2 tandem channel co-expressed with SUR2AY Kono
Department of Cardiovascular Medicine, Kyoto University Graduate School of Medicine, Japan
Pflugers Arch 440:692-8. 2000..2 to MgATP (IC50=95.5+/-49.6 microM versus 18.9+/-5.0 microM). These results suggest that Kir6.1 and Kir6.2 are endowed with the potential to form a heteromeric KATP channel, which has a low sensitivity to MgATP...
- SYR2, a gene necessary for syringomycin growth inhibition of Saccharomyces cerevisiaeP Cliften
Department of Biology and Program in Molecular Biology, Utah State University, Logan 84322 5305, USA
Microbiology 142:477-84. 1996..SYR2 was identical to SUR2, which is involved in survival during nutritional starvation...
- Heart mitochondria contain functional ATP-dependent K+ channelsZsombor Lacza
Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Mol Cell Cardiol 35:1339-47. 2003..was performed with antibodies against K(ATP)-channel subunits, namely the sulfonylurea receptor (SUR1 or SUR2) and the inwardly rectifying K+ channel (Kir6.1 or Kir6.2). Specific Kir6.1 and Kir6...
- Investigation of the subunit composition and the pharmacology of the mitochondrial ATP-dependent K+ channel in the brainZsombor Lacza
Department of Physiology Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
Brain Res 994:27-36. 2003..In contrast, we found no evidence for the presence of either known sulfonylurea receptors (SUR1 or SUR2) in the mitochondria...
- Ras induces mediator complex exchange on C/EBP betaXianming Mo
Max Delbruck Center for Molecular Medicine, Robert Roessle Str 10, 13092 Berlin, Germany
Mol Cell 13:241-50. 2004..Active and repressive C/EBPbeta interacts with multisubunit Mediator complexes through the CRSP130/Sur2 subunit...
- Glibenclamide-induced apoptosis is specifically enhanced by expression of the sulfonylurea receptor isoform SUR1 but not by expression of SUR2B or the mutant SUR1(M1289T)Annette Hambrock
Department of Pharmacology and Toxicology, Medical Faculty, University of Tubingen, Tubingen, Germany
J Pharmacol Exp Ther 316:1031-7. 2006..at which a single amino acid in transmembrane helix 17 (TM17) was exchanged by the corresponding amino acid of SUR2. By analyzing cell detachment, nuclear condensation, DNA fragmentation, and caspase-3-like activity, we observed a ..
- Identification and characterization of a novel member of the ATP-sensitive K+ channel subunit family, Kir6.3, in zebrafishChangliang Zhang
Division of Cellular and Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
Physiol Genomics 24:290-7. 2006..We also identified zebrafish orthologs corresponding to mammalian SUR1 (zSUR1) and SUR2 (zSUR2) by the genomic database. Both Kir6...
- A novel Val734Ile variant in the ABCC9 gene associated with myocardial infarctionPiercarlo Minoretti
Department of Cardiology, Alessandro Manzoni Hospital of Lecco, Lecco, Italy
Clin Chim Acta 370:124-8. 2006..are deemed to play an important role in myocardial infarction (MI), and the ATP-binding cassette transporter C9-ABCC9-may be involved in the regulation of coronary artery vasomotility...
- A haplotype in the human Sur2 gene is associated with essential hypertensionN Sato
Division of Genomic Epidemiology and Clinical Trials, Advanced Medical Research Center, Tokyo, Japan
J Hum Hypertens 20:87-90. 2006
- Sulphonylurea receptors differently modulate ICC pacemaker Ca2+ activity and smooth muscle contractilityShinsuke Nakayama
Department of Cell Physiology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
J Cell Sci 118:4163-73. 2005..expression of the type 1 isoform of sulphonylurea receptors (SUR1) in ICCs of the mouse ileum, but expression of SUR2 was predominant in smooth muscle...
- A Link between ethylene and auxin uncovered by the characterization of two root-specific ethylene-insensitive mutants in ArabidopsisAnna N Stepanova
Department of Genetics, North Carolina State University, Raleigh, North Carolina 27695, USA
Plant Cell 17:2230-42. 2005..Furthermore, wei2 and wei7 suppress the high-auxin phenotypes of superroot1 (sur1) and sur2, two auxin-overproducing mutants, suggesting that the roles of WEI2 and WEI7 in the regulation of auxin ..
- Limited role for SREBP-1c in defective glucose-induced insulin secretion from Zucker diabetic fatty rat islets: a functional and gene profiling analysisLaura E Parton
Henry Wellcome Signaling Laboratories and Department of Biochemistry, School of Medical Sciences, University of Bristol, Bristol, United Kingdom
Am J Physiol Endocrinol Metab 291:E982-94. 2006..2, Rab3), stimulated (voltage-dependent Ca(2+) channel subunit alpha1D, CPT2, SUR2, rab9, syt13), or inhibited (syntaxin 7, secretogranin-2) by SREBP-1c inhibition...
- Cardiac KATP channels in health and diseaseGarvan C Kane
Division of Cardiovascular Diseases, Department of Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
J Mol Cell Cardiol 38:937-43. 2005..findings are underscored by the identification in humans that defective K(ATP) channels induced by mutations in ABCC9, the gene encoding the cardiac sulfonylurea receptor subunit, confer susceptibility to dilated cardiomyopathy...
- Effect of two amino acids in TM17 of Sulfonylurea receptor SUR1 on the binding of ATP-sensitive K+ channel modulatorsAnnette Hambrock
Department of Pharmacology and Toxicology, Medical Faculty, University of Tubingen, Wilhelmstrasse 56, D 72074 Tubingen, Germany
Diabetes 53:S128-34. 2004..SUR isoform, shows much higher affinity for glibenclamide but considerably lower affinity for most openers than SUR2. In radioligand binding assays, we investigated the role of two amino acids, T1285 and M1289, located in ..
- Molecular characterization of a local sulfonylurea system in human adipose tissueBritt G Gabrielsson
Research Centre for Endocrinology and Metabolism, Department of Internal Medicine, The Sahlgrenska Academy at Goteborg University, Goteborg, Sweden
Mol Cell Biochem 258:65-71. 2004..Two different SUR genes (SUR1 and SUR2) and two different Kir6.x genes (Kir6.1 and Kir6.2) have been identified...
- E1A-CR3 interaction-dependent and -independent functions of mSur2 in viral replication of early region 1A mutants of mouse adenovirus type 1Lei Fang
Department of Microbiology and Immunology, University of Michigan Medical School, 1150 W Medical Center Dr, 6723 Medical Science Bldg II, Ann Arbor, MI 48109 0620, USA
J Virol 79:3267-76. 2005..At a multiplicity of infection (MOI) of 1, viruses containing CR3 replicated better in Sur2+/+ mouse embryonic fibroblasts (MEFs) than in Sur2-/- MEFs...
- Structural requirements of sulphonylureas and analogues for interaction with sulphonylurea receptor subtypesM Meyer
Institute of Pharmacology and Toxicology, Technical University of Braunschweig, Mendelssohnstrasse 1, D 38106 Braunschweig, Germany
Br J Pharmacol 128:27-34. 1999..3. Meglitinide (benzoic acid derivative) bound to SUR1 and the SUR2 isoforms with similar affinities...
- Syntaxin-1A actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac K(ATP) channel activationYouhou Kang
Department of Medicine, University of Toronto, Toronto, Canada M5S 1A8
J Biol Chem 281:19019-28. 2006....
- Development of HTS Assay:PK(ATP)FLIPR Channels (RMI)Xinmin Xie; Fiscal Year: 2005..2 subunits) for primary screening and against the muscle form (e. g. , SUR2/Kir6...
- SUR Transmembrane Domain in K(ATP) Channel FunctionRobert Harvey; Fiscal Year: 2006..g. SUR1, SUR2), and (ii) an Inwardly rectifying potassium (j about) channel subunit (Kir6; e.g. Kir6.1, Kir6.2)...
- Molecular Regulation of Cardiac KATP Channels in IschemiaJonathan Makielski; Fiscal Year: 2009..The sulfonylurea receptor subunit SUR2 regulates pharmacology and nucleotide interactions for sKATP, but the role of SUR2 in mKATP is unknown...
- Molecular Regulation of Cardiac KATP Channels in IschemiaJonathan C Makielski; Fiscal Year: 2010..The sulfonylurea receptor subunit SUR2 regulates pharmacology and nucleotide interactions for sKATP, but the role of SUR2 in mKATP is unknown...
- Genetic Markers of GIK Effect in Acute Coronary Syndrome in the IMMEDIATE TrialInga Peter; Fiscal Year: 2009..and IDE), fatty acid metabolism regulation (PRKAA2, PPARA, and PPARG), and potassium channel activity (KCNJ11 and ABCC9) in the heart will be associated with the immediate and long-term response to GIK therapy administered in the ..
- Genetic Markers of GIK Effect in Acute Coronary Syndrome in the IMMEDIATE TrialInga Peter; Fiscal Year: 2007..and IDE), fatty acid metabolism regulation (PRKAA2, PPARA, and PPARG), and potassium channel activity (KCNJ11 and ABCC9) in the heart will be associated with the immediate and long-term response to GIK therapy administered in the ..
- Sulfonylurea KATP channels in vascular spasmElizabeth McNally; Fiscal Year: 2009Potassium ATP (KATP) channels are composed of a sulfonylurea subunit, SUR1 or SUR2, and a pore forming potassium channel, Kir6.1 or Kir6.2...
- BIOSYNTHESIS OF ADENOVIRUS EARLY RNA'SARNOLD BERK; Fiscal Year: 2007..region 3 (CR3) as a model activation domain, capitalizing on recent work showing that it activates by binding the Sur2 subunit of the mammalian Mediator complex...
- Molecular Regulation - Cardiac KATP Channels in IschemiaJonathan Makielski; Fiscal Year: 2006..The sulfonylurea receptor subunit SUR2 regulates pharmacology and nucleotide interactions for surface KATP, but the molecular nature of the subunit for ..
- Role of Kir6.1 subunits of K+ channels in heartWILLIAM COETZEE; Fiscal Year: 2004..1 and Kir6.2) - both are highly expressed in heart. Cardiac KATP channels are believed to consist of Kir6.2/SUR2 complexes. However, the role of Kir6.1 is unknown...
- MOLECULAR REGULATION--CARDIAC K+ATP CHANNELS IN ISCHEMIAJonathan Makielski; Fiscal Year: 2001..Investigators on native cardiac KATP, by the recent availability of KATP clones (co- expressed BIR/SUR1 and KATP/SUR2), and by a structural hypothesis of phospholipid effects involving the cytoplasmic C-tail of the KATP...
- Phosphoinositides and ATP-sensitive K+ channels in heartZheng Fan; Fiscal Year: 2005..2 association modulates ATP binding. (3) We will investigate the role of SUR2, the regulatory subunit of the KATPchannel, in PPI-KATP channel interaction and PPI modulation of ATP binding...
- Mapping Novel Disease Genes for Dilated CardiomyopathyTIMOTHY MARK OLSON; Fiscal Year: 2010..Discovering the genetic basis of DCM will lead to better ways to diagnose and prevent the progressive weakening of heart muscle that afflicts patients with this disorder. ..
- Mapping Novel Disease Genes for Dilated CardiomyopathyTimothy Olson; Fiscal Year: 2004..The long-term objectives of this work are to gain new insights into molecular mechanisms for heart failure and to improve prediction, prevention, and treatment of DCM. ..
- Identification of Disease Genes for Atrial FibrillationTimothy Olson; Fiscal Year: 2009..The long-term objectives of this work are to gain new insights into molecular mechanisms of arrhythmogenesis and to improve prediction, prevention, and treatment of AF. ..
- Mapping Novel Disease Genes for Dilated CardiomyopathyTimothy Olson; Fiscal Year: 2007..Discovering the genetic basis of DCM will lead to better ways to diagnose and prevent the progressive weakening of heart muscle that afflicts patients with this disorder. ..
- Identification of Disease Genes for Atrial FibrillationTimothy Olson; Fiscal Year: 2007..The long-term objectives of this work are to gain new insights into molecular mechanisms of arrhythmogenesis and to improve prediction, prevention, and treatment of AF. ..
- Pathological role of the SUR1-regulated NC(Ca-ATP) channel in cortex after subaraJ Marc Simard; Fiscal Year: 2010..In this proposal, we will use a rat model of SAH to establish the essential role of the NC(Ca-ATP) channel in pathophysiology post-SAH. ..
- Cloning a major gene for mouse adenovirus susceptibilityKatherine R Spindler; Fiscal Year: 2010..The project is expected to identify a previously undescribed intractiorT^ieT^eerrK6sfiTrTrmrne res immune evasion, thus increasing our understanding of viral infections and mechanisms of host response to pathogens. ~ ..
- Cloning a major gene for mouse adenovirus susceptibilityKATHERINE SPINDLER; Fiscal Year: 2007..The project is expected to identify a previously undescribed interaction between host immune response and viral immune evasion, thus increasing our understanding of viral infections and mechanisms of host response to pathogens. ..
- Sulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic strokeJ Marc Simard; Fiscal Year: 2007..End of Abstract) ..
- Spinal cord injury, progressive hemorrhagic necrosis and the NC(Ca-ATP) channelJ Marc Simard; Fiscal Year: 2009..These studies will form the basis for novel future therapies for spinal cord injury. ..
- Sulfonylurea receptor 1 (SUR1)- A novel therapeutic target in ischemic strokeJ Marc Simard; Fiscal Year: 2009..End of Abstract) ..
- PATHOPHYSIOLOGY OF NICOTINE IN CEREBRAL BLOOD VESSELSJ Simard; Fiscal Year: 2004....