ABCC9

Summary

Gene Symbol: ABCC9
Description: ATP binding cassette subfamily C member 9
Alias: ABC37, ATFB12, CANTU, CMD1O, SUR2, ATP-binding cassette sub-family C member 9, ATP-binding cassette transporter sub-family C member 9, ATP-binding cassette, sub-family C (CFTR/MRP), member 9, sulfonylurea receptor 2
Species: human
Products:     ABCC9

Top Publications

  1. Wang Y, Zheng H, Liu S. Effects of ATP-sensitive potassium channels on the expression of P21, P27 and leptin. J Huazhong Univ Sci Technolog Med Sci. 2009;29:8-11 pubmed publisher
    ..The results showed that the expression of SUR2, not SUR1 was detected in adipose tissue, preadipocytes and adipocytes...
  2. Inagaki N, Gonoi T, Clement J, Wang C, Aguilar Bryan L, Bryan J, et al. A family of sulfonylurea receptors determines the pharmacological properties of ATP-sensitive K+ channels. Neuron. 1996;16:1011-7 pubmed
    We have cloned an isoform of the sulfonylurea receptor (SUR), designated SUR2. Coexpression of SUR2 and the inward rectifier K+ channel subunit Kir6...
  3. Chutkow W, Simon M, Le Beau M, Burant C. Cloning, tissue expression, and chromosomal localization of SUR2, the putative drug-binding subunit of cardiac, skeletal muscle, and vascular KATP channels. Diabetes. 1996;45:1439-45 pubmed
    ..Northern blotting showed that the highest expression of the SUR2 isoforms is in the heart and skeletal muscle, with lower levels in all other tissues...
  4. Aguilar Bryan L, Clement J, Gonzalez G, Kunjilwar K, Babenko A, Bryan J. Toward understanding the assembly and structure of KATP channels. Physiol Rev. 1998;78:227-45 pubmed
    ..The availability of cloned KATP channel genes opens the way for characterization of this family of ion channels and identification of additional genetic defects...
  5. Lorenz E, Terzic A. Physical association between recombinant cardiac ATP-sensitive K+ channel subunits Kir6.2 and SUR2A. J Mol Cell Cardiol. 1999;31:425-34 pubmed
    ..The demonstration of complex formation between Kir6.2 and SUR2A indicates that the structural basis for channel function may rely on direct physical interaction of the two subunits. ..
  6. Bienengraeber M, Olson T, Selivanov V, Kathmann E, O Cochlain F, Gao F, et al. ABCC9 mutations identified in human dilated cardiomyopathy disrupt catalytic KATP channel gating. Nat Genet. 2004;36:382-7 pubmed
    ..with heart failure and rhythm disturbances due to idiopathic dilated cardiomyopathy identified two mutations in ABCC9, which encodes the regulatory SUR2A subunit of the cardiac K(ATP) channel...
  7. Shimbo T, Adachi T, Fujisawa S, Hongoh M, Ohba T, Ono K. In vitro effect of nicorandil on the carbachol-induced contraction of the lower esophageal sphincter of the rat. J Pharmacol Sci. 2016;131:267-74 pubmed publisher
    ..1), KCNJ11 (Kir6.2), ABCC8 (SUR1) and ABCC9 (SUR2) subunits of the KATP channel in the rat lower esophagus...
  8. Liang G, Adebiyi A, Leo M, McNally E, Leffler C, Jaggar J. Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels. Am J Physiol Heart Circ Physiol. 2011;300:H2088-95 pubmed publisher
    ..also studied in pressurized resistance-size cerebral arteries of mice with a genetic deletion in the gene encoding SUR2 (SUR2 null)...
  9. Newfield R. Topical sulfonylurea as a novel therapy for hypertrichosis secondary to diazoxide, and potentially for other conditions with excess hair growth. Med Hypotheses. 2015;85:969-71 pubmed publisher
    ..This approach can also be applied to rare cases of Cantú syndrome, caused by mutations in ABCC9 (coding for SUR2) or in KCNJ8 (coding for Kir6.1) that is characterized by congenital hypertrichosis...

More Information

Publications113 found, 100 shown here

  1. Kim D, Kim I, Papreck J, Donnelly D, Carroll J. Characterization of an ATP-sensitive K(+) channel in rat carotid body glomus cells. Respir Physiol Neurobiol. 2011;177:247-55 pubmed publisher
    ..Reverse transcriptase-PCR and immunocytochemistry showed that Kir6.1, Kir6.2, SUR1 and SUR2 were expressed in CB glomus cells as well as in non-glomus cells...
  2. Moreau C, Jacquet H, Prost A, D hahan N, Vivaudou M. The molecular basis of the specificity of action of K(ATP) channel openers. EMBO J. 2000;19:6644-51 pubmed
    ..g. pinacidil, cromakalim, nicorandil) act specifically on the SUR2 muscle isoforms but, except for diazoxide, remain ineffective on the SUR1 neuronal/pancreatic isoform...
  3. Tamura Y, Tanabe K, Kitagawa W, Uchida S, Schreiner G, Johnson R, et al. Nicorandil, a K(atp) channel opener, alleviates chronic renal injury by targeting podocytes and macrophages. Am J Physiol Renal Physiol. 2012;303:F339-49 pubmed publisher
    ..Interestingly, these two cell types express sulfonylurea receptor 2 (SUR2), a binding site of nicorandil in the ATP-dependent K channel...
  4. Liu Z, Li W, Ma X, Ding N, Spallotta F, Southon E, et al. Essential role of the zinc finger transcription factor Casz1 for mammalian cardiac morphogenesis and development. J Biol Chem. 2014;289:29801-16 pubmed publisher
    ..TNNI2, TNNT1, and CKM; contractile fiber gene ACTA1; and cardiac arrhythmia associated ion channel coding genes ABCC9 and CACNA1D. The transcriptional regulation of some of these genes by Casz1 was also found in cellular models...
  5. Kawano T, Zoga V, McCallum J, Wu H, Gemes G, Liang M, et al. ATP-sensitive potassium currents in rat primary afferent neurons: biophysical, pharmacological properties, and alterations by painful nerve injury. Neuroscience. 2009;162:431-43 pubmed publisher
    ..Using specific antibodies, we identified SUR1, SUR2, and Kir6.2 but not Kir6.1 subunits in DRGs...
  6. Benamer N, Vasquez C, Mahoney V, Steinhardt M, Coetzee W, Morley G. Fibroblast KATP currents modulate myocyte electrophysiology in infarcted hearts. Am J Physiol Heart Circ Physiol. 2013;304:H1231-9 pubmed publisher
    ..4 ± 7.5 pA/pF at 50 mV) in sMI-Fb that was inhibited with 10 ?mol/l glibenclamide. Kir6.2 and SUR2 transcript levels were elevated in sMI-Fb. Treatment with Kir6...
  7. Simard J, Chen M. Regulation by sulfanylurea receptor type 1 of a non-selective cation channel involved in cytotoxic edema of reactive astrocytes. J Neurosurg Anesthesiol. 2004;16:98-9 pubmed
    ..mRNA transcription and protein expression of SUR1 but not SUR2 were confirmed in reactive astrocytes both in situ and after isolation, whereas Kir6...
  8. Fardo D, Katsumata Y, Kauwe J, Deming Y, Harari O, Cruchaga C, et al. CSF protein changes associated with hippocampal sclerosis risk gene variants highlight impact of GRN/PGRN. Exp Gerontol. 2017;90:83-89 pubmed publisher
    ..the association between CSF analytes and risk SNPs in four genes (SNPs): GRN (rs5848), TMEM106B (rs1990622), ABCC9 (rs704180), and KCNMB2 (rs9637454)...
  9. Noh J, Hoang V, Kim Y, Kang J, Yang D. Chryseobacterium ginsengiterrae sp. nov., with Beta-Glucosidase Activity Isolated from Soil of a Ginseng Field. Curr Microbiol. 2017;74:1417-1424 pubmed publisher
    ..nov DCY68T belonged to the family Flavobacteriaceae and was most closely related to C. limigenitum SUR2T (97.4%). The genomic DNA G+C content was 42.0 mol%. The predominant quinones were MK-6 (74...
  10. Lee K, Dixon A, Richardson P, Pinnock R. Glucose-receptive neurones in the rat ventromedial hypothalamus express KATP channels composed of Kir6.1 and SUR1 subunits. J Physiol. 1999;515 ( Pt 2):439-52 pubmed
    ..1 and SUR1 but not Kir6.2 or SUR2. 6...
  11. Hiraki Y, Takanari H. A new type of ATP-sensitive potassium channelopathy : Cantú syndrome. No To Hattatsu. 2016;48:325-31 pubmed
    ..Recently, Cantú syndrome (CS), which was found to be caused by mutations in the ABCC9 or KCNJ8 gene, was newly added to the list of KATP channelopathies...
  12. Yasui K, Mihara S, Zhao C, Okamoto H, Saito Ohara F, Tomida A, et al. Alteration in copy numbers of genes as a mechanism for acquired drug resistance. Cancer Res. 2004;64:1403-10 pubmed
    ..cassette (ABC) transporter genes [ABCA3, ABCB1 (MDR1), ABCB6, ABCB8, ABCB10, ABCB11, ABCC1 (MRP1), ABCC4, ABCC9, ABCD3, ABCD4, ABCE1, and ABCF2] were amplified among 19 of the resistant cell lines examined...
  13. Kharade S, Nichols C, Denton J. The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics. Future Med Chem. 2016;8:789-802 pubmed publisher
    ..new therapeutics for the treatment of certain forms of neonatal diabetes mellitus, congenital hyperinsulinism and Cantu syndrome...
  14. Schumacher T, Benndorf R. ABC Transport Proteins in Cardiovascular Disease-A Brief Summary. Molecules. 2017;22: pubmed publisher
    ..Subsequently, further ABC transporters, i.e., ABCG1, ABCG4, ABCB6, ABCC1, ABCC6 or ABCC9, have been shown to directly or indirectly affect cellular cholesterol efflux, the inflammatory response in ..
  15. Liu T, Chen Y, Jong Y, Tsai H, Lee C, Chang Y, et al. Muscle developmental defects in heterogeneous nuclear Ribonucleoprotein A1 knockout mice. Open Biol. 2017;7: pubmed publisher
    ..the alternative splicing patterns of muscle development-related genes including mef2c, lrrfip1, usp28 and abcc9 Alternative mRNA isoforms of these genes were increased in hnRNP A1+/- mice compared with wild-type ..
  16. Bondjers C, He L, Takemoto M, Norlin J, Asker N, Hellstrom M, et al. Microarray analysis of blood microvessels from PDGF-B and PDGF-Rbeta mutant mice identifies novel markers for brain pericytes. FASEB J. 2006;20:1703-5 pubmed
    ..1 (also known as Kcnj8) and sulfonylurea receptor 2, (SUR2, also known as Abcc9), both part of the same channel complex, as well as delta homologue 1 (DLK1) ..
  17. Kane G, Liu X, Yamada S, Olson T, Terzic A. Cardiac KATP channels in health and disease. J Mol Cell Cardiol. 2005;38:937-43 pubmed
    ..findings are underscored by the identification in humans that defective K(ATP) channels induced by mutations in ABCC9, the gene encoding the cardiac sulfonylurea receptor subunit, confer susceptibility to dilated cardiomyopathy...
  18. Yang Y, Li S, Konduru A, Zhang S, Trower T, Shi W, et al. Prolonged exposure to methylglyoxal causes disruption of vascular KATP channel by mRNA instability. Am J Physiol Cell Physiol. 2012;303:C1045-54 pubmed publisher
    ..Luciferase reporter assays indicated that the 3'-untranslated regions (UTRs) of the Kir6.1 but not SUR2 mRNA were targeted by MGO...
  19. Tessadori F, Roessler H, Savelberg S, Chocron S, Kamel S, Duran K, et al. Effective CRISPR/Cas9-based nucleotide editing in zebrafish to model human genetic cardiovascular disorders. Dis Model Mech. 2018;11: pubmed publisher
    ..1, KCNJ8) and regulatory (SUR2, ABCC9) subunits of an ATP-sensitive potassium channel (KATP) linked to Cantú syndrome (CS)...
  20. Grady B, Torstenson E, McLaren P, de Bakker P, Haas D, Robbins G, et al. Use of biological knowledge to inform the analysis of gene-gene interactions involved in modulating virologic failure with efavirenz-containing treatment regimens in ART-naïve ACTG clinical trials participants. Pac Symp Biocomput. 2011;:253-64 pubmed
    ..model remained significant after correction for multiple comparisons, an interaction between SNPs in the TAP1 and ABCC9 genes was one of the top models before correction...
  21. Elsnerova K, Bartakova A, Tihlarik J, Bouda J, Rob L, Skapa P, et al. Gene Expression Profiling Reveals Novel Candidate Markers of Ovarian Carcinoma Intraperitoneal Metastasis. J Cancer. 2017;8:3598-3606 pubmed publisher
    ..High expressions of ABCA2/8/9/10, ABCB1, ABCC9, ABCG2, ATP7A, SLC16A14, and SOD3 genes were significantly associated with longer ..
  22. Kim H, Kim S, Jeon H, Kim J, Yoo J, Seong M, et al. Clinical and Molecular Delineation of a Novel Cys1050Phe Missense Mutation in the ABCC9 Gene in a Korean Patient with Cantú Syndrome. Clin Lab. 2017;63:991-995 pubmed publisher
    ..Here we report the first case of Cantú syndrome in Korea and the associated changes in overall development with rehabilitation over several months. ..
  23. Fan Z, Neff R. Susceptibility of ATP-sensitive K+ channels to cell stress through mediation of phosphoinositides as examined by photoirradiation. J Physiol. 2000;529 Pt 3:707-21 pubmed
    ..were recorded from cell-attached and inside-out patches of rat ventricular myocytes and COS-1 cells coexpressing SUR2 and Kir6.2. KATP channel activity increased within < 1 min upon irradiation...
  24. Nakayama S, Ohya S, Liu H, Watanabe T, Furuzono S, Wang J, et al. Sulphonylurea receptors differently modulate ICC pacemaker Ca2+ activity and smooth muscle contractility. J Cell Sci. 2005;118:4163-73 pubmed
    ..expression of the type 1 isoform of sulphonylurea receptors (SUR1) in ICCs of the mouse ileum, but expression of SUR2 was predominant in smooth muscle...
  25. Zhang C, Miki T, Shibasaki T, Yokokura M, Saraya A, Seino S. Identification and characterization of a novel member of the ATP-sensitive K+ channel subunit family, Kir6.3, in zebrafish. Physiol Genomics. 2006;24:290-7 pubmed
    ..We also identified zebrafish orthologs corresponding to mammalian SUR1 (zSUR1) and SUR2 (zSUR2) by the genomic database. Both Kir6...
  26. Kim S, Lee Y, Kim J. Reduced expression and abnormal localization of the K(ATP) channel subunit SUR2A in patients with familial hypokalemic periodic paralysis. Biochem Biophys Res Commun. 2010;391:974-8 pubmed publisher
    ..These findings suggest that abnormal localization of the SUR2A K(+) channel protein leads to reduced K(ATP) channel activity in familial hypokalemic periodic paralysis...
  27. Vidal Taboada J, Pugliese M, Salvado M, Gamez J, Mahy N, Rodriguez M. KATP Channel Expression and Genetic Polymorphisms Associated with Progression and Survival in Amyotrophic Lateral Sclerosis. Mol Neurobiol. 2018;55:7962-7972 pubmed publisher
    ..We also characterized new functional variants of human ABCC8, ABCC9, KCNJ8, and KCNJ11 genes encoding for the KATP channel and analyzed their association with ALS risk, ..
  28. Croker B, Crozat K, Berger M, Xia Y, Sovath S, Schaffer L, et al. ATP-sensitive potassium channels mediate survival during infection in mammals and insects. Nat Genet. 2007;39:1453-60 pubmed
    ..The phenotype is due to a null allele of Kcnj8, encoding Kir6.1, a protein that combines with SUR2 to form an ATP-sensitive potassium channel (K(ATP)) expressed in coronary artery smooth muscle and endothelial ..
  29. Isomoto S, Kondo C, Yamada M, Matsumoto S, Higashiguchi O, Horio Y, et al. A novel sulfonylurea receptor forms with BIR (Kir6.2) a smooth muscle type ATP-sensitive K+ channel. J Biol Chem. 1996;271:24321-4 pubmed
    ..Sequence analysis indicated that this clone is a variant of cardiac type sulfonylurea receptor (SUR2)...
  30. Nakaya H, Miki T, Seino S, Yamada K, Inagaki N, Suzuki M, et al. [Molecular and functional diversity of ATP-sensitive K+ channels: the pathophysiological roles and potential drug targets]. Nihon Yakurigaku Zasshi. 2003;122:243-50 pubmed
    ..1 or Kir6.2) and the regulatory subunit sulfonylurea receptors (SUR1 or SUR2)...
  31. Curley M, Cairns M, Friel A, McMeel O, Morrison J, Smith T. Expression of mRNA transcripts for ATP-sensitive potassium channels in human myometrium. Mol Hum Reprod. 2002;8:941-5 pubmed
    ..05) were still observed. Our results indicate that the major K(ATP) channel expressed in human myometrium is composed of Kir6.1 and SUR2B, and that down-regulation of this channel may facilitate myometrial function during late pregnancy...
  32. Kang Y, Ng B, Leung Y, He Y, Xie H, Lodwick D, et al. Syntaxin-1A actions on sulfonylurea receptor 2A can block acidic pH-induced cardiac K(ATP) channel activation. J Biol Chem. 2006;281:19019-28 pubmed
  33. Wang Y, Zheng H, Qin N, Yu S, Liu S. Involvement of ATP-sensitive potassium channels in proliferation and differentiation of rat preadipocytes. Sheng Li Xue Bao. 2007;59:8-12 pubmed
    ..We examined the expression of sulphonylurea receptor 2 (SUR2) mRNA in preadipocytes and adipocytes obtained by inducing for 5 d and the effects of the inhibitor (glibenclamide) ..
  34. Chan K, Wheeler A, CSANADY L. Sulfonylurea receptors type 1 and 2A randomly assemble to form heteromeric KATP channels of mixed subunit composition. J Gen Physiol. 2008;131:43-58 pubmed
    ..The reported expression of both SUR1 and SUR2 together with Kir6...
  35. Nelson P, Trojanowski J, Abner E, Al Janabi O, Jicha G, Schmitt F, et al. "New Old Pathologies": AD, PART, and Cerebral Age-Related TDP-43 With Sclerosis (CARTS). J Neuropathol Exp Neurol. 2016;75:482-98 pubmed publisher
    ..In this review, we provide an overview of current hypotheses about how genetic risk factors (GRN, TMEM106B, ABCC9, and KCNMB2), and other pathogenetic influences contribute to TDP-43 pathology and hippocampal sclerosis...
  36. McClenaghan C, Hanson A, Sala Rabanal M, Roessler H, Josifova D, Grange D, et al. Cantu syndrome-associated SUR2 (ABCC9) mutations in distinct structural domains result in KATP channel gain-of-function by differential mechanisms. J Biol Chem. 2018;293:2041-2052 pubmed publisher
    The complex disorder Cantu syndrome (CS) arises from gain-of-function mutations in either KCNJ8 or ABCC9, the genes encoding the Kir6.1 and SUR2 subunits of ATP-sensitive potassium (KATP) channels, respectively...
  37. Stoller D, Fahrenbach J, Chalupsky K, Tan B, Aggarwal N, Metcalfe J, et al. Cardiomyocyte sulfonylurea receptor 2-KATP channel mediates cardioprotection and ST segment elevation. Am J Physiol Heart Circ Physiol. 2010;299:H1100-8 pubmed publisher
    ..Mice deleted for the first nucleotide binding region of sulfonylurea receptor 2 (SUR2) are referred to as SUR2 null since they lack full-length SUR2 and glibenclamide-responsive K(ATP) ..
  38. Cooper P, Sala Rabanal M, Lee S, Nichols C. Differential mechanisms of Cantú syndrome-associated gain of function mutations in the ABCC9 (SUR2) subunit of the KATP channel. J Gen Physiol. 2015;146:527-40 pubmed publisher
    ..Recent genetic analysis has revealed that the majority of CS patients carry a missense mutation in ABCC9, which codes for the sulfonylurea receptor SUR2. SUR2 subunits couple with Kir6...
  39. Zhang L, Tester D, Lang D, Chen Y, Zheng J, Gao R, et al. Does Sudden Unexplained Nocturnal Death Syndrome Remain the Autopsy-Negative Disorder: A Gross, Microscopic, and Molecular Autopsy Investigation in Southern China. Mayo Clin Proc. 2016;91:1503-1514 pubmed publisher
    ..Twelve of 44 SUNDS victims (SCN5A, SCN1B, CACNB2, CACNA1C, AKAP9, KCNQ1, KCNH2, KCNJ5, GATA4, NUP155, ABCC9) and 6 of 17 patients with BrS (SCN5A, CACNA1C; P>...
  40. Levin M, Singh G, Zhang H, Uchida K, Kozel B, Stein P, et al. K(ATP) channel gain-of-function leads to increased myocardial L-type Ca(2+) current and contractility in Cantu syndrome. Proc Natl Acad Sci U S A. 2016;113:6773-8 pubmed publisher
    ..1, KCNJ8) and accessory (SUR2, ABCC9) KATP channel subunits...
  41. Gao M, Xue H, Wang Y, Wang H. Iptakalim, opener of K(ATP), reverses the enhanced expression of genes encoding K(ATP) subunits in spontaneously hypertensive rats. Life Sci. 2005;77:2743-51 pubmed
    ..In this study, the expression of genes encoding the K(ATP) subunits, SUR2, Kir6.1 and Kir6...
  42. Nichols C. Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection. Card Electrophysiol Clin. 2016;8:323-35 pubmed publisher
    ..SUR2 variants with specific cardiovascular electrical and contractile derangements and the clear association with Cantu syndrome establish the importance of appropriate activity in normal function of the heart and vasculature...
  43. Deeley R, Westlake C, Cole S. Transmembrane transport of endo- and xenobiotics by mammalian ATP-binding cassette multidrug resistance proteins. Physiol Rev. 2006;86:849-99 pubmed
    ..with the cystic fibrosis conductance regulator (CFTR/ABCC7) and the sulfonylurea receptors (SUR1/ABCC8 and SUR2/ABCC9) comprise the 13 members of the human "C" branch of the ATP binding cassette (ABC) superfamily...
  44. Burke M, Mutharasan R, Ardehali H. The sulfonylurea receptor, an atypical ATP-binding cassette protein, and its regulation of the KATP channel. Circ Res. 2008;102:164-76 pubmed publisher
    ..Here, we review the structure and function of ABC proteins and discuss SUR, its regulation of the K(ATP) channel, and its role in cardiovascular disease...
  45. Jiao J, Garg V, Yang B, Elton T, Hu K. Protein kinase C-epsilon induces caveolin-dependent internalization of vascular adenosine 5'-triphosphate-sensitive K+ channels. Hypertension. 2008;52:499-506 pubmed publisher
    ..This finding provides a novel mechanistic insight into how K(ATP) channels are regulated in vascular smooth muscle cells...
  46. Glukhov A, Flagg T, Fedorov V, Efimov I, Nichols C. Differential K(ATP) channel pharmacology in intact mouse heart. J Mol Cell Cardiol. 2010;48:152-60 pubmed publisher
    Classically, cardiac sarcolemmal K(ATP) channels have been thought to be composed of Kir6.2 (KCNJ11) and SUR2A (ABCC9) subunits...
  47. Marques P, Spencer R, Morrison P, Carr I, Dang M, Bonthron D, et al. Cantú syndrome with coexisting familial pituitary adenoma. Endocrine. 2018;59:677-684 pubmed publisher
    ..members, with marked acromegaloid facies and prominent hypertrichosis, due to a novel missense variant in the ABCC9 gene...
  48. Uhde I, Toman A, Gross I, Schwanstecher C, Schwanstecher M. Identification of the potassium channel opener site on sulfonylurea receptors. J Biol Chem. 1999;274:28079-82 pubmed
    ..between SUR1 and SUR2B, we identify two regions (KCO I: Thr(1059)-Leu(1087) and KCO II: Arg(1218)-Asn(1320); rat SUR2 numbering) within the second set of transmembrane domains (TMDII) as critical for KCO binding...
  49. Lovász N, Ducza E, Gaspar R, Falkay G. [Ontogeny of sulphonylurea-binding regulatory subunits of K(ATP) channels in the pregnant rat myometrium]. Acta Pharm Hung. 2011;81:101-7 pubmed
    ..to examine the expression and role of sulphonylurea-binding regulatory subunits 1 [SUR1 (ABCC8)] and 2 [SUR2 (ABCC9)] of the K(ATP) channels in the pregnant rat myometrium with particular regard to the contractility...
  50. Nelson P, Estus S, Abner E, Parikh I, Malik M, Neltner J, et al. ABCC9 gene polymorphism is associated with hippocampal sclerosis of aging pathology. Acta Neuropathol. 2014;127:825-43 pubmed publisher
    ..Polymorphism in the ATP-binding cassette, sub-family C member 9 (ABCC9) gene, also known as sulfonylurea receptor 2, was associated with HS-Aging pathology...
  51. Akao M, Otani H, Horie M, Takano M, Kuniyasu A, Nakayama H, et al. Myocardial ischemia induces differential regulation of KATP channel gene expression in rat hearts. J Clin Invest. 1997;100:3053-9 pubmed
    ..1 and/or Kir6.2) subunit and the sulfonylurea receptor (SUR2). This channel is activated during myocardial ischemia and protects the heart from ischemic injury...
  52. de Araujo E, Ikeda L, Tzvetkova S, Kanelis V. The first nucleotide binding domain of the sulfonylurea receptor 2A contains regulatory elements and is folded and functions as an independent module. Biochemistry. 2011;50:6655-66 pubmed publisher
  53. Le Gallo M, O Hara A, Rudd M, Urick M, Hansen N, O Neil N, et al. Exome sequencing of serous endometrial tumors identifies recurrent somatic mutations in chromatin-remodeling and ubiquitin ligase complex genes. Nat Genet. 2012;44:1310-5 pubmed publisher
    ..of somatic mutations in CHD4 (17%), EP300 (8%), ARID1A (6%), TSPYL2 (6%), FBXW7 (29%), SPOP (8%), MAP3K4 (6%) and ABCC9 (6%). Overall, 36...
  54. McLaughlin M, He Y, Brunstrom Hernandez J, Thio L, Carleton B, Ross C, et al. Pharmacogenomic Variability of Oral Baclofen Clearance and Clinical Response in Children With Cerebral Palsy. PM R. 2018;10:235-243 pubmed publisher
    ..After univariate analysis of the data, the SNP of ABCC9 (rs11046232, heterozygous AT versus the reference TT genotype) was associated with a 2-fold increase in oral ..
  55. Cuong D, Kim N, Joo H, Youm J, Chung J, Lee Y, et al. Subunit composition of ATP-sensitive potassium channels in mitochondria of rat hearts. Mitochondrion. 2005;5:121-33 pubmed
    ..Anti-Kir6.1, anti-Kir6.2, and anti-SUR2 immunofluorescence was colocalized with that of MitoTracker Red in isolated mitochondria, suggesting that Kir6...
  56. Hambrock A, de Oliveira Franz C, Hiller S, Osswald H. Glibenclamide-induced apoptosis is specifically enhanced by expression of the sulfonylurea receptor isoform SUR1 but not by expression of SUR2B or the mutant SUR1(M1289T). J Pharmacol Exp Ther. 2006;316:1031-7 pubmed
    ..at which a single amino acid in transmembrane helix 17 (TM17) was exchanged by the corresponding amino acid of SUR2. By analyzing cell detachment, nuclear condensation, DNA fragmentation, and caspase-3-like activity, we observed a ..
  57. Szamosfalvi B, Cortes P, Alviani R, Asano K, Riser B, Zasuwa G, et al. Putative subunits of the rat mesangial KATP: a type 2B sulfonylurea receptor and an inwardly rectifying K+ channel. Kidney Int. 2002;61:1739-49 pubmed
    ..Because these responses likely resulted from the binding of sulfonylurea to a mesangial SUR2, we subsequently documented [3H]-glibenclamide binding to MC and the gene expression of several mesangial SUR2 ..
  58. Jin X, Malykhina A, Lupu F, Akbarali H. Altered gene expression and increased bursting activity of colonic smooth muscle ATP-sensitive K+ channels in experimental colitis. Am J Physiol Gastrointest Liver Physiol. 2004;287:G274-85 pubmed
    ..1 and Kir 6.2) and the sulfonylurea receptor (SUR1 and SUR2). In gastrointestinal smooth muscle, these channels are important in regulating cell excitability...
  59. Tagmose T, Schou S, Mogensen J, Nielsen F, Arkhammar P, Wahl P, et al. Arylcyanoguanidines as activators of Kir6.2/SUR1K ATP channels and inhibitors of insulin release. J Med Chem. 2004;47:3202-11 pubmed
    ..It also highlights that small structural changes can dramatically shift the efficacy of the cyanoguanidine type of selective activators of Kir6.2/SUR2 potassium channels.
  60. Jöns T, Wittschieber D, Beyer A, Meier C, Brune A, Thomzig A, et al. K+-ATP-channel-related protein complexes: potential transducers in the regulation of epithelial tight junction permeability. J Cell Sci. 2006;119:3087-97 pubmed
    ..The data presented here shed new light on the physiological and pathophysiological role K(+)-ATP channels might have for the regulation of tight junctions...
  61. Lybaert P, Vanbellinghen A, Quertinmont E, Petein M, Meuris S, Lebrun P. KATP channel subunits are expressed in the epididymal epithelium in several mammalian species. Biol Reprod. 2008;79:253-61 pubmed publisher
    ..A positive immunostaining for Kir6.2 (KCNJ11) and SUR2 (ABCC9) was observed by immunoenzymatic and immunofluorescent approaches in the principal epithelial cells throughout all ..
  62. Benamer N, Moha Ou Maati H, Demolombe S, Cantereau A, Delwail A, Bois P, et al. Molecular and functional characterization of a new potassium conductance in mouse ventricular fibroblasts. J Mol Cell Cardiol. 2009;46:508-17 pubmed publisher
    ..Among potassium channel transcripts which were screened by high-throughput real-time PCR, SUR2 and Kir6.1 mRNAs were found to be the most abundant in ventricular fibroblasts...
  63. Ellis J, Lamantia A, Chavez R, Scurrah K, Nichols C, Harrap S. Genes controlling postural changes in blood pressure: comprehensive association analysis of ATP-sensitive potassium channel genes KCNJ8 and ABCC9. Physiol Genomics. 2010;40:184-8 pubmed publisher
    ..genomewide linkage analysis suggests a region on chromosome 12p that harbors two strong candidate genes, KCNJ8 and ABCC9, encoding the channel-forming inward rectifier subunit Kir6...
  64. Aggarwal N, Pravdic D, McNally E, Bosnjak Z, Shi N, Makielski J. The mitochondrial bioenergetic phenotype for protection from cardiac ischemia in SUR2 mutant mice. Am J Physiol Heart Circ Physiol. 2010;299:H1884-90 pubmed publisher
    The sulfonylurea receptor-2 (SUR2) is a subunit of ATP-sensitive potassium channels (K(ATP)) in heart. Mice with the SUR2 gene disrupted (SUR2m) are constitutively protected from ischemia-reperfusion (I/R) cardiac injury...
  65. Harakalová M, van Harssel J, Terhal P, van Lieshout S, Duran K, Renkens I, et al. Dominant missense mutations in ABCC9 cause Cantú syndrome. Nat Genet. 2012;44:793-6 pubmed publisher
    ..By using family-based exome sequencing, we identified a de novo mutation in ABCC9. Subsequently, we discovered novel dominant missense mutations in ABCC9 in 14 of the 16 individuals with Cantú ..
  66. Crawford R, Budas G, Jovanovic S, Ranki H, Wilson T, Davies A, et al. M-LDH serves as a sarcolemmal K(ATP) channel subunit essential for cell protection against ischemia. EMBO J. 2002;21:3936-48 pubmed
  67. Ploug K, Sørensen M, Strøbech L, Klaerke D, Hay Schmidt A, Sheykhzade M, et al. K ATP channels in pig and human intracranial arteries. Eur J Pharmacol. 2008;601:43-9 pubmed publisher
    ..Specific blocking of Kir6.1 or SUR2B K(ATP) channel subunits in large cerebral and meningeal arteries may be a future anti-migraine strategy...
  68. Garg V, Sun W, Hu K. Caveolin-3 negatively regulates recombinant cardiac K(ATP) channels. Biochem Biophys Res Commun. 2009;385:472-7 pubmed publisher
    ..The association of K(ATP) channels with caveolin-3 was largely prevented by caveolin-3 scaffolding domain peptide. Our results indicate that caveolin-3 negatively regulates Kir6.2/SUR2A channel function...
  69. Maack C, Dabew E, Hohl M, Schäfers H, Bohm M. Endogenous activation of mitochondrial KATP channels protects human failing myocardium from hydroxyl radical-induced stunning. Circ Res. 2009;105:811-7 pubmed publisher
    ..Furthermore, although ATP-dependent K+ channels (K(ATP) channels) are implicated in myocardial protection during ischemia/reperfusion ("ischemic preconditioning"), their role in heart failure has hardly been elucidated...
  70. Allebrandt K, Amin N, Muller Myhsok B, Esko T, Teder Laving M, Azevedo R, et al. A K(ATP) channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila. Mol Psychiatry. 2013;18:122-32 pubmed publisher
    ..We identified an intronic variant (rs11046205; P=3.99 × 10(-8)) in the ABCC9 gene that explains ?5% of the variation in sleep duration...
  71. Kefaloyianni E, Lyssand J, Moreno C, Delaroche D, Hong M, Fenyo D, et al. Comparative proteomic analysis of the ATP-sensitive K+ channel complex in different tissue types. Proteomics. 2013;13:368-78 pubmed publisher
    ..1 and/or Kir6.2) and four regulatory sulfonylurea receptor subunits (SUR1 and/or SUR2)...
  72. Bayat G, Javan M, Safari F, Khalili A, Shokri S, Goudarzvand M, et al. Nandrolone decanoate negatively reverses the beneficial effects of exercise on cardiac muscle via sarcolemmal, but not mitochondrial K(ATP) channel. Can J Physiol Pharmacol. 2016;94:324-31 pubmed publisher
    ..The expression of sarcolemmal, but not mitochondrial, subunits of K(ATP) channel (Kir6.2 and SUR2) of EC group was significantly higher compared with SC group while ND administration (SND group) did not show any ..
  73. Pérez Serra A, Toro R, Sarquella Brugada G, De Gonzalo Calvo D, Cesar S, Carro E, et al. Genetic basis of dilated cardiomyopathy. Int J Cardiol. 2016;224:461-472 pubmed publisher
    ..We review the recent published data about genetics of familial dilated cardiomyopathy. ..
  74. Davis Taber R, Choi W, Feng J, Hoogenboom L, McNally T, Kroeger P, et al. Molecular characterization of human SUR2-containing K(ATP) channels. Gene. 2000;256:261-70 pubmed
    The distribution of human sulfonylurea receptor-2 (SUR2)-containing K(ATP) channels was investigated using reverse transcriptase-polymerase chain reaction (RT-PCR)...
  75. Horinaka S, Kobayashi N, Higashi T, Hara K, Hara S, Matsuoka H. Nicorandil enhances cardiac endothelial nitric oxide synthase expression via activation of adenosine triphosphate-sensitive K channel in rat. J Cardiovasc Pharmacol. 2001;38:200-10 pubmed
    ..e., an ATP-binding cassette protein sulfonylurea receptor (SUR2) and a pore-forming inward rectifier (Kir6.1 or 6.2)...
  76. Melaine N, Satie A, Lassurguere J, Desmots S, Jégou B, Samson M. Molecular cloning of several rat ABC transporters including a new ABC transporter, Abcb8, and their expression in rat testis. Int J Androl. 2006;29:392-9 pubmed
    ..cDNA found, five corresponded to ABC transporters already known -Mdr1b, Mrp1, Tapl/Abcb9, Umat/Abcb6 and Sur2/Abcc9- and one presented a strong homology with mouse and human ABCB8...
  77. Bryan J, Munoz A, Zhang X, Dufer M, Drews G, Krippeit Drews P, et al. ABCC8 and ABCC9: ABC transporters that regulate K+ channels. Pflugers Arch. 2007;453:703-18 pubmed
    The sulfonylurea receptors (SURs) ABCC8/SUR1 and ABCC9/SUR2 are members of the C-branch of the transport adenosine triphosphatase superfamily...
  78. Zhang H, Flagg T, Nichols C. Cardiac sarcolemmal K(ATP) channels: Latest twists in a questing tale!. J Mol Cell Cardiol. 2010;48:71-5 pubmed publisher
    ..1, KCNJ8, and Kir6.2 KCNJ11) with sulfonylurea receptors (SUR1, ABCC8, and SUR2, ABCC9) of the ABCC protein sub-family, has led to the elucidation of many details of channel gating and pore properties, ..
  79. Olson T, Terzic A. Human K(ATP) channelopathies: diseases of metabolic homeostasis. Pflugers Arch. 2010;460:295-306 pubmed publisher
    ..with mechanical and/or electrical heart disease include dilated cardiomyopathy (with ventricular arrhythmia; CMD1O) and adrenergic atrial fibrillation. A common Kir6...
  80. Zhou M, He H, Tanaka O, Sekiguchi M, Kawahara K, Abe H. Localization of the ATP-sensitive K(+) channel regulatory subunits SUR2A and SUR2B in the rat brain. Neurosci Res. 2012;74:91-105 pubmed publisher
    ..b>SUR2 mRNA is widely expressed in many neurons and glial cells as revealed by in situ hybridization histochemistry...
  81. Tricarico D, Maqoud F, Curci A, Camerino G, Zizzo N, Denora N, et al. Characterization of minoxidil/hydroxypropyl-?-cyclodextrin inclusion complex in aqueous alginate gel useful for alopecia management: Efficacy evaluation in male rat. Eur J Pharm Biopharm. 2018;122:146-157 pubmed publisher
    ..The MXD/HP-?-CD GEL significantly enhanced the mRNA levels of the SUR2 and Kir6.1 subunits of the KATP channels and AKT2 vs other groups...
  82. Scott V, Davis Taber R, Silvia C, Hoogenboom L, Choi W, Kroeger P, et al. Characterization of human urinary bladder KATP channels containing SUR2B splice variants expressed in L-cells. Eur J Pharmacol. 2004;483:195-205 pubmed
    The molecular properties of the sulfonylurea receptor 2 (SUR2) subunits of K(ATP) channels expressed in urinary bladder were assessed by polymerase chain reaction (PCR)...
  83. Edwards A, Rees M, Gioscia R, Zachman D, Lynch J, Browder J, et al. PKC-permitted elevation of sarcolemmal KATP concentration may explain female-specific resistance to myocardial infarction. J Physiol. 2009;587:5723-37 pubmed publisher
    ..HMR, 27 +/- 3%), and PKC blockade had no additional effect (HMR + Chel, 26 +/- 2%). The prevalence of Kir6.2 and SUR2 was higher in the sarcolemmal fractions of females (Kir6.2: F, 1.24 +/- 0.07 vs. M, 1.02 +/- 0.06; SUR2: F, 3...
  84. Liu D, Liu X, Zhou L, Feng X, Zhang X. Expression of sulfonylurea receptors in rat taste buds. Acta Histochem. 2011;113:489-92 pubmed publisher
    ..staining was used to detect the expression and distribution of sulfonylurea receptor 1 (SUR1) or sulfonylurea receptor 2 (SUR2) in rat taste buds...
  85. Bao L, Hadjiolova K, Coetzee W, Rindler M. Endosomal KATP channels as a reservoir after myocardial ischemia: a role for SUR2 subunits. Am J Physiol Heart Circ Physiol. 2011;300:H262-70 pubmed publisher
    ..We demonstrate an essential role for SUR2 subunits in trafficking K(ATP) channels to an intracellular vesicular compartment. Transfection of Kir6...
  86. Fatima N, Schooley J, Claycomb W, Flagg T. Promoter DNA methylation regulates murine SUR1 (Abcc8) and SUR2 (Abcc9) expression in HL-1 cardiomyocytes. PLoS ONE. 2012;7:e41533 pubmed publisher
    Two mammalian genes encode the SURx (SUR1, Abcc8 and SUR2, Abcc9) subunits that combine with Kir6.2 (Kcnj11) subunits to form the ATP-sensitive potassium (KATP) channel in cardiac myocytes...
  87. Katsumata Y, Nelson P, Ellingson S, Fardo D. Gene-based association study of genes linked to hippocampal sclerosis of aging neuropathology: GRN, TMEM106B, ABCC9, and KCNMB2. Neurobiol Aging. 2017;53:193.e17-193.e25 pubmed publisher
    ..To learn more about genetic risk of HS-Aging pathology, we tested gene-based associations of the GRN, TMEM106B, ABCC9, and KCNMB2 genes, which were reported to be associated with HS-Aging pathology in previous studies...
  88. Horinaka S, Kobayashi N, Yabe A, Asakawa H, Yagi H, Mori Y, et al. Nicorandil protects against lethal ischemic ventricular arrhythmias and up-regulates endothelial nitric oxide synthase expression and sulfonylurea receptor 2 mRNA in conscious rats with acute myocardial infarction. Cardiovasc Drugs Ther. 2004;18:13-22 pubmed
    ..At 24 hours after treatment, eNOS, iNOS, and SUR2 mRNA levels and eNOS, iNOS expression in the left ventricle were determined by reverse transcription polymerase ..
  89. Tammaro P, Ashcroft F. The Kir6.2-F333I mutation differentially modulates KATP channels composed of SUR1 or SUR2 subunits. J Physiol. 2007;581:1259-69 pubmed
    ..2-F333I/SUR channel types was reduced, although SUR1-containing channels were reduced more than SUR2-containing channels. These results suggest F333 is involved in differential coupling of Kir6.2 to SUR1 and SUR2...
  90. de Wet H, Fotinou C, Amad N, Dreger M, Ashcroft F. The ATPase activities of sulfonylurea receptor 2A and sulfonylurea receptor 2B are influenced by the C-terminal 42 amino acids. FEBS J. 2010;277:2654-62 pubmed publisher
    ..2 subunits and four regulatory SUR subunits. Two different genes encode SUR1 (ABCC8) and SUR2 (ABCC9), with the latter being differentially spliced to give SUR2A and SUR2B, which differ only in their C-terminal 42 ..