ABCC6

Summary

Gene Symbol: ABCC6
Description: ATP binding cassette subfamily C member 6
Alias: ABC34, ARA, EST349056, GACI2, MLP1, MOAT-E, MOATE, MRP6, PXE, PXE1, URG7, multidrug resistance-associated protein 6, URG7 protein, ATP-binding cassette, sub-family C (CFTR/MRP), member 6, anthracycline resistance-associated protein, multi-specific organic anion transporter E
Species: human
Products:     ABCC6

Top Publications

  1. Le Saux O, Urban Z, Tschuch C, Csiszar K, Bacchelli B, Quaglino D, et al. Mutations in a gene encoding an ABC transporter cause pseudoxanthoma elasticum. Nat Genet. 2000;25:223-7 pubmed
    ..Here we report the exclusion of five of these genes and the identification of the first mutations responsible for the development of PXE in a gene encoding a protein associated with multidrug resistance (ABCC6).
  2. Fülöp K, Jiang Q, Wetering K, Pomozi V, Szabó P, Arányi T, et al. ABCC6 does not transport vitamin K3-glutathione conjugate from the liver: relevance to pathomechanisms of pseudoxanthoma elasticum. Biochem Biophys Res Commun. 2011;415:468-71 pubmed publisher
    ..It has been suggested that ABCC6 may have a role in transporting vitamin K or its derivatives from the liver to the periphery...
  3. Uitto J, Pulkkinen L, Ringpfeil F. Molecular genetics of pseudoxanthoma elasticum: a metabolic disorder at the environment-genome interface?. Trends Mol Med. 2001;7:13-7 pubmed
    ..Recently, PXE has been linked to mutations in the MRP6/ABCC6 gene, a member of the ABC transporter family, expressed primarily in the liver and the kidneys...
  4. Jansen R, Küçükosmanoglu A, de Haas M, Sapthu S, Otero J, Hegman I, et al. ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release. Proc Natl Acad Sci U S A. 2013;110:20206-11 pubmed publisher
    ..PXE is caused by inactivating mutations in the gene encoding ATP-binding cassette sub-family C member 6 (ABCC6), an ATP-dependent efflux transporter present mainly in the liver...
  5. Neldner K. Pseudoxanthoma elasticum. Clin Dermatol. 1988;6:1-159 pubmed
  6. Uitto J. The gene family of ABC transporters--novel mutations, new phenotypes. Trends Mol Med. 2005;11:341-3 pubmed
    ..Recently, mutations in two ABC-transporter genes, ABCC6 and ABCA12, have been demonstrated to underlie phenotypically different diseases affecting the skin (..
  7. Chassaing N, Martin L, Calvas P, Le Bert M, Hovnanian A. Pseudoxanthoma elasticum: a clinical, pathophysiological and genetic update including 11 novel ABCC6 mutations. J Med Genet. 2005;42:881-92 pubmed
    ..PXE was recently associated with mutations in the ABCC6 (ATP binding cassette subtype C number 6) gene. At least one ABCC6 mutation is found in about 80% of patients...
  8. Schulz V, Hendig D, Szliska C, Gotting C, Kleesiek K. Novel mutations in the ABCC6 gene of German patients with pseudoxanthoma elasticum. Hum Biol. 2005;77:367-84 pubmed
    ..Recently, the PXE candidate gene ABCC6 was identified and a limited number of ABCC6 mutations were observed in different PXE cohorts...
  9. Hu X, Plomp A, Gorgels T, Brink J, Loves W, Mannens M, et al. Efficient molecular diagnostic strategy for ABCC6 in pseudoxanthoma elasticum. Genet Test. 2004;8:292-300 pubmed
    ..The two most frequent mutations, R1141X and an ABCC6 del exons 23-29, as well as a core set of mutations, were identified by restriction enzyme digestion and size ..

More Information

Publications82

  1. Jansen R, Duijst S, Mahakena S, Sommer D, Szeri F, Varadi A, et al. ABCC6-mediated ATP secretion by the liver is the main source of the mineralization inhibitor inorganic pyrophosphate in the systemic circulation-brief report. Arterioscler Thromb Vasc Biol. 2014;34:1985-9 pubmed publisher
    Mutations in ABCC6 underlie the ectopic mineralization disorder pseudoxanthoma elasticum (PXE) and some forms of generalized arterial calcification of infancy, both of which affect the cardiovascular system...
  2. Sinkó E, Iliás A, Ujhelly O, Homolya L, Scheffer G, Bergen A, et al. Subcellular localization and N-glycosylation of human ABCC6, expressed in MDCKII cells. Biochem Biophys Res Commun. 2003;308:263-9 pubmed
    Mutations in the gene coding for a human ABC transporter protein, ABCC6 (MRP6), are responsible for the development of pseudoxanthoma elasticum...
  3. Li Q, Grange D, Armstrong N, Whelan A, Hurley M, Rishavy M, et al. Mutations in the GGCX and ABCC6 genes in a family with pseudoxanthoma elasticum-like phenotypes. J Invest Dermatol. 2009;129:553-63 pubmed publisher
    ..feature of classic pseudoxanthoma elasticum (PXE), an autosomal recessive disorder caused by mutations in the ABCC6 gene, is aberrant mineralization of connective tissues, particularly the elastic fibers...
  4. Hu X, Peek R, Plomp A, ten Brink J, Scheffer G, van Soest S, et al. Analysis of the frequent R1141X mutation in the ABCC6 gene in pseudoxanthoma elasticum. Invest Ophthalmol Vis Sci. 2003;44:1824-9 pubmed
    To characterize the ABCC6 R1141X nonsense mutation, which is implicated in more than 25% of a cohort of patients from The Netherlands with pseudoxanthoma elasticum (PXE)...
  5. Trip M, Smulders Y, Wegman J, Hu X, Boer J, ten Brink J, et al. Frequent mutation in the ABCC6 gene (R1141X) is associated with a strong increase in the prevalence of coronary artery disease. Circulation. 2002;106:773-5 pubmed
    ..Recently, we and others have identified mutations in the gene coding for the ABCC6 transporter in PXE patients with ocular and skin involvement...
  6. Wang J, Near S, Young K, Connelly P, Hegele R. ABCC6 gene polymorphism associated with variation in plasma lipoproteins. J Hum Genet. 2001;46:699-705 pubmed
    ..b>ABCC6 is another member of the ABC gene family, and mutations in ABCC6 were recently shown to cause pseudoxanthoma ..
  7. Ratajewski M, de Boussac H, Pulaski L. Liver-specific enhancer in ABCC6 promoter-Functional evidence from natural polymorphisms. Biochem Biophys Res Commun. 2009;383:73-7 pubmed publisher
    Pseudoxanthoma elasticum (PXE) is a heritable connective tissue disease caused by mutations in the ABCC6 gene that encodes a transmembrane transporter of unknown function, expressed mainly in the liver...
  8. Le Saux O, Beck K, Sachsinger C, Silvestri C, Treiber C, Göring H, et al. A spectrum of ABCC6 mutations is responsible for pseudoxanthoma elasticum. Am J Hum Genet. 2001;69:749-64 pubmed
    ..pseudoxanthoma elasticum (PXE), we performed a mutational analysis of ATP-binding cassette subfamily C member 6 (ABCC6) in 122 unrelated patients with PXE, the largest cohort of patients yet studied...
  9. Uitto J, Li Q, Jiang Q. Pseudoxanthoma elasticum: molecular genetics and putative pathomechanisms. J Invest Dermatol. 2010;130:661-70 pubmed publisher
    ..The classic forms of PXE are due to loss-of-function mutations in the ABCC6 gene, which encodes ABCC6, a transmembrane efflux transporter expressed primarily in the liver...
  10. Belinsky M, Kruh G. MOAT-E (ARA) is a full-length MRP/cMOAT subfamily transporter expressed in kidney and liver. Br J Cancer. 1999;80:1342-9 pubmed
    ..In the present study we describe the fourth MRP/cMOAT-related transporter. We analysed ARA, a human cDNA reported to encode a 453 residue MRP-related transporter, and found that it represents a fused ..
  11. Pomozi V, Le Saux O, Brampton C, Apana A, Iliás A, Szeri F, et al. ABCC6 is a basolateral plasma membrane protein. Circ Res. 2013;112:e148-51 pubmed publisher
    b>ABCC6 plays a crucial role in ectopic calcification; mutations of the gene cause pseudoxanthoma elasticum and general arterial calcification of infancy...
  12. Fülöp K, Barna L, Symmons O, Zavodszky P, Varadi A. Clustering of disease-causing mutations on the domain-domain interfaces of ABCC6. Biochem Biophys Res Commun. 2009;379:706-9 pubmed publisher
    Mutations in ABCC6 are responsible for pseudoxanthoma elasticum (PXE), a rare genetic disease affecting the elastic tissues of the body. ABCC6 encodes a 1503 amino acid long ABC transporter, ABCC6/MRP6...
  13. Finger R, Charbel Issa P, Ladewig M, Gotting C, Szliska C, Scholl H, et al. Pseudoxanthoma elasticum: genetics, clinical manifestations and therapeutic approaches. Surv Ophthalmol. 2009;54:272-85 pubmed publisher
    ..Its prevalence has been estimated to be 1:25,000-100,000. Very recently, the ABCC6 gene on chromosome 16p13.1 was found to be associated with the disease...
  14. Chassaing N, Martin L, Bourthoumieu S, Calvas P, Hovnanian A. Contribution of ABCC6 genomic rearrangements to the diagnosis of pseudoxanthoma elasticum in French patients. Hum Mutat. 2007;28:1046 pubmed
    ..PXE is caused by mutations in ABCC6 encoding a multidrug resistance protein (ABCC6, also known as MRP6)...
  15. Costrop L, Vanakker O, Van Laer L, Le Saux O, Martin L, Chassaing N, et al. Novel deletions causing pseudoxanthoma elasticum underscore the genomic instability of the ABCC6 region. J Hum Genet. 2010;55:112-7 pubmed publisher
    Mutations in ABCC6 cause pseudoxanthoma elasticum (PXE), a heritable disease that affects elastic fibers...
  16. Miksch S, Lumsden A, Guenther U, Foernzler D, Christen Zäch S, Daugherty C, et al. Molecular genetics of pseudoxanthoma elasticum: type and frequency of mutations in ABCC6. Hum Mutat. 2005;26:235-48 pubmed
    ..Mutations in the ABCC6 gene cause PXE...
  17. de Boussac H, Ratajewski M, Sachrajda I, Koblos G, Tordai A, Pulaski L, et al. The ERK1/2-hepatocyte nuclear factor 4alpha axis regulates human ABCC6 gene expression in hepatocytes. J Biol Chem. 2010;285:22800-8 pubmed publisher
    b>ABCC6 mutations are responsible for the development of pseudoxanthoma elasticum, a rare recessive disease characterized by calcification of elastic fibers...
  18. Hornstrup L, Tybjærg Hansen A, Haase C, Nordestgaard B, Sillesen H, Grande P, et al. Heterozygosity for R1141X in ABCC6 and risk of ischemic vascular disease. Circ Cardiovasc Genet. 2011;4:534-41 pubmed publisher
    Pseudoxanthoma elasticum (PXE) is an autosomal recessive disease caused by loss-of-function mutations in ABCC6 and characterized by elastic calcification leading to dermal, ocular, and ischemic vascular disease...
  19. Kool M, Van der Linden M, de Haas M, Baas F, Borst P. Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells. Cancer Res. 1999;59:175-82 pubmed
    ..encoding the canalicular multispecific organic anion transporter; and four homologues, called MRP3, MRP4, MRP5, and MRP6. The most recently discovered member of the family, MRP6, is analyzed in this report...
  20. Arányi T, Ratajewski M, Bardóczy V, Pulaski L, Bors A, Tordai A, et al. Identification of a DNA methylation-dependent activator sequence in the pseudoxanthoma elasticum gene, ABCC6. J Biol Chem. 2005;280:18643-50 pubmed
    b>ABCC6 encodes MRP6, a member of the ABC protein family with an unknown physiological role. The human ABCC6 and its two pseudogenes share 99% identical DNA sequence...
  21. Hu X, Plomp A, Wijnholds J, Ten Brink J, van Soest S, van den Born L, et al. ABCC6/MRP6 mutations: further insight into the molecular pathology of pseudoxanthoma elasticum. Eur J Hum Genet. 2003;11:215-24 pubmed
    ..Recently, we and others showed that PXE is caused by mutations in the ABCC6/MRP6 gene...
  22. Iliás A, Urban Z, Seidl T, Le Saux O, Sinkó E, Boyd C, et al. Loss of ATP-dependent transport activity in pseudoxanthoma elasticum-associated mutants of human ABCC6 (MRP6). J Biol Chem. 2002;277:16860-7 pubmed
    Mutations in the ABCC6 (MRP6) gene cause pseudoxanthoma elasticum (PXE), a rare heritable disorder resulting in the calcification of elastic fibers...
  23. Bergen A, Plomp A, Schuurman E, Terry S, Breuning M, Dauwerse H, et al. Mutations in ABCC6 cause pseudoxanthoma elasticum. Nat Genet. 2000;25:228-31 pubmed
    ..Here we describe homozygosity mapping in five PXE families and the detection of deletions or mutations in ABCC6 (formerly MRP6) associated with all genetic forms of PXE in seven patients or families.
  24. Le Saux O, Bunda S, VanWart C, Douet V, Got L, Martin L, et al. Serum factors from pseudoxanthoma elasticum patients alter elastic fiber formation in vitro. J Invest Dermatol. 2006;126:1497-505 pubmed
    ..PXE is caused by mutations in ABCC6, a gene encoding an ABC transporter predominantly expressed in liver and kidneys...
  25. Schulz V, Hendig D, Henjakovic M, Szliska C, Kleesiek K, Gotting C. Mutational analysis of the ABCC6 gene and the proximal ABCC6 gene promoter in German patients with pseudoxanthoma elasticum (PXE). Hum Mutat. 2006;27:831 pubmed
    ..Recently, ABCC6 mutations were identified as causing PXE...
  26. Pfendner E, Vanakker O, Terry S, Vourthis S, McAndrew P, McClain M, et al. Mutation detection in the ABCC6 gene and genotype-phenotype analysis in a large international case series affected by pseudoxanthoma elasticum. J Med Genet. 2007;44:621-8 pubmed
    ..It is caused by mutations in the ABCC6 (ATP binding cassette family C member 6) gene, which encodes MRP6 (multidrug resistance-associated protein 6)...
  27. Ringpfeil F, Lebwohl M, Christiano A, Uitto J. Pseudoxanthoma elasticum: mutations in the MRP6 gene encoding a transmembrane ATP-binding cassette (ABC) transporter. Proc Natl Acad Sci U S A. 2000;97:6001-6 pubmed
    ..1, without evidence for locus heterogeneity. In this study, we report pathogenetic mutations in MRP6, a member of the ABC transporter gene family, in eight kindreds with PXE...
  28. Gheduzzi D, Guidetti R, Anzivino C, Tarugi P, Di Leo E, Quaglino D, et al. ABCC6 mutations in Italian families affected by pseudoxanthoma elasticum (PXE). Hum Mutat. 2004;24:438-9 pubmed
    ..cardiovascular clinical symptoms, caused by mutations in a gene (ABCC6) that encodes for MRP6 (Multidrug Resistance associated Protein 6), an ATP-binding cassette membrane transporter...
  29. Koblos G, Andrikovics H, Prohaszka Z, Tordai A, Varadi A, Arányi T. The R1141X loss-of-function mutation of the ABCC6 gene is a strong genetic risk factor for coronary artery disease. Genet Test Mol Biomarkers. 2010;14:75-8 pubmed publisher
    Loss-of-function mutations of ABCC6 cause pseudoxanthoma elasticum (PXE)...
  30. Symmons O, Varadi A, Arányi T. How segmental duplications shape our genome: recent evolution of ABCC6 and PKD1 Mendelian disease genes. Mol Biol Evol. 2008;25:2601-13 pubmed publisher
    ..We focused on PKD1 and ABCC6 duplications because mutations affecting these genes are responsible for the Mendelian disorders autosomal ..
  31. Hu X, Plomp A, van Soest S, Wijnholds J, De Jong P, Bergen A. Pseudoxanthoma elasticum: a clinical, histopathological, and molecular update. Surv Ophthalmol. 2003;48:424-38 pubmed
    ..Using linkage analysis and mutation detection techniques, mutations in the ABCC6 gene were recently implicated in the etiology of pseudoxanthoma elasticum...
  32. Nitschke Y, Baujat G, Botschen U, Wittkampf T, du Moulin M, Stella J, et al. Generalized arterial calcification of infancy and pseudoxanthoma elasticum can be caused by mutations in either ENPP1 or ABCC6. Am J Hum Genet. 2012;90:25-39 pubmed publisher
    ..GACI is associated with biallelic mutations in ENPP1 in the majority of cases, whereas mutations in ABCC6 are known to cause PXE. However, the genetic basis in subsets of both disease phenotypes remains elusive...
  33. Pulkkinen L, Nakano A, Ringpfeil F, Uitto J. Identification of ABCC6 pseudogenes on human chromosome 16p: implications for mutation detection in pseudoxanthoma elasticum. Hum Genet. 2001;109:356-65 pubmed
    ..disorder affecting the skin, eyes, and the cardiovascular system, has recently been linked to mutations in the ABCC6 gene on chromosome 16p13.1...
  34. Marinho G, Holdt S, Jacobsen C, Angelidaki I. Lipids and Composition of Fatty Acids of Saccharina latissima Cultivated Year-Round in Integrated Multi-Trophic Aquaculture. Mar Drugs. 2015;13:4357-74 pubmed publisher
    ..beneficial PUFA's, eicosapentaenoic (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3), but also arachidonic (ARA) and stearidonic acid (SDA), which are not found in land vegetables such as cabbage and lettuce...
  35. Laothanachareon T, Bunterngsook B, Suwannarangsee S, Eurwilaichitr L, Champreda V. Synergistic action of recombinant accessory hemicellulolytic and pectinolytic enzymes to Trichoderma reesei cellulase on rice straw degradation. Bioresour Technol. 2015;198:682-90 pubmed publisher
    ..this study, the synergistic action of three recombinant accessory enzymes, namely GH62 α-l-arabinofuranosidase (ARA), CE8 pectin esterase (PET), and GH10 endo-1,4-beta-xylanase (XYL) from Aspergillus aculeatus expressed in Pichia ..
  36. Aghazadeh Habashi A, Asghar W, Jamali F. Drug-Disease Interaction: Effect of Inflammation and Nonsteroidal Anti-Inflammatory Drugs on Cytochrome P450 Metabolites of Arachidonic Acid. J Pharm Sci. 2018;107:756-763 pubmed publisher
    ..celecoxib, and meloxicam) on the physiologically active cytochrome P450 metabolites of arachidonic acid (ArA) in the rat with adjuvant arthritis...
  37. Hu T, Tie C, Wang Z, Zhang J. Highly sensitive and specific derivatization strategy to profile and quantitate eicosanoids by UPLC-MS/MS. Anal Chim Acta. 2017;950:108-118 pubmed publisher
    Eicosanoids are signaling molecules mainly oxidized from arachidonic acid (ARA) and eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA)...
  38. Zu L, Guo G, Zhou B, Gao W. Relationship between metabolites of arachidonic acid and prognosis in patients with acute coronary syndrome. Thromb Res. 2016;144:192-201 pubmed publisher
    To investigate the correlation of arachidonic acid (ARA) metabolites and prognosis in ACS patients. This is a mono-center retrospective nested case-control study...
  39. Fang D, He S, Xiong G, Singla N, Cao Z, Zhang L, et al. Comparison of clinicopathologic characteristics, epigenetic biomarkers and prognosis between renal pelvic and ureteral tumors in upper tract urothelial carcinoma. BMC Urol. 2018;18:22 pubmed publisher
    ..001), specifically for TMEFF2, GDF15, RASSF1A, SALL3 and ABCC6 (all p < 0.05)...
  40. Pope F. Autosomal dominant pseudoxanthoma elasticum. J Med Genet. 1974;11:152-7 pubmed
  41. Wang F, Zhang W, He A, Cao X, Chen Y, Zhao W, et al. Effect of granulocyte colony-stimulating factor priming combined with low-dose cytarabine and homoharringtonine in higher risk myelodysplastic syndrome patients. Leuk Res. 2016;48:57-61 pubmed publisher
    ..The regimen, G-HA, consisted of cytarabine (Ara-C) 7.5mg/m(2)/12h by subcutaneous injection, days 1-14, homoharringtonine (HHT) 1...
  42. Jia R, Li Q, Shen W, Zhang J, Zheng L, Wang G. Antinociceptive activity of a polysaccharide from the roots of Sophora flavescens. Int J Biol Macromol. 2016;93:501-505 pubmed publisher
    ..Glc, (1?2,6)-inkedGal and (1?3,6)-inked Man residues, which were terminated with (1?)-inked Xyl and (1?)-inked Ara at O-6 of (1?2,6)-inkedGal and (1?3,6)-inked Man along the main chain, in the ratio of 2.0: 1.02: 1.09: 1.10: 0.98...
  43. Chen L, Guo P, Zhang Y, Li X, Jia P, Tong J, et al. Autophagy is an important event for low-dose cytarabine treatment in acute myeloid leukemia cells. Leuk Res. 2017;60:44-52 pubmed publisher
    Cytarabine (Ara-c) has been an important agent in acute myeloid leukemia (AML) treatment for more than 40 years. While, the mechanisms underlying low dose cytarabine (LD Ara-c) is poorly understood...
  44. Nishie R, Toya N, Fukushima S, Ito E, Murakami Y, Akiba T, et al. Prophylactic accessory renal artery coil embolization for prevention of type II endoleak following endovascular aneurysm repair: a case report. Surg Case Rep. 2017;3:58 pubmed publisher
    ..Here, we report a case of prophylactic coil embolization for a 4 mm ARA originating from an abdominal aortic aneurysm...
  45. Yuan Z, Rapoport S. Transient postnatal fluoxetine decreases brain concentrations of 20-HETE and 15-epi-LXA4, arachidonic acid metabolites in adult mice. Prostaglandins Leukot Essent Fatty Acids. 2015;101:9-14 pubmed publisher
    ..fluoxetine alters behavior and brain 5-HT neurotransmission during adulthood, and also reduces brain arachidonic (ARA) metabolic consumption and protein level of the ARA metabolizing enzyme, cytochrome P4504A (CYP4A)...
  46. Kuroda M, Kobayashi Y, Tanaka Y, Itani T, Mifuji R, Araki J, et al. Increased hepatic and renal expressions of multidrug resistance-associated protein 3 in Eisai hyperbilirubinuria rats. J Gastroenterol Hepatol. 2004;19:146-53 pubmed
    ..The aim of the present study was to investigate adaptive expressions of mrp1, mrp3, mrp6, organic anion transporting polypeptide 1 (oatp1) and oatp2 in liver and kidney of EHBR.
  47. Bridges K, Pereira Da Silva L, Tou J, Ziegler J, Brunetti L. Bone metabolism in very preterm infants receiving total parenteral nutrition: do intravenous fat emulsions have an impact?. Nutr Rev. 2015;73:823-36 pubmed publisher
    ..Cumulative net deficiencies of calcium, phosphorus, docosahexaenoic acid (DHA), and arachidonic acid (ARA) are evident in these infants after prolonged administration of total parenteral nutrition (TPN)...
  48. Olaru L, Soong L, Dhillon S, Yacyshyn E. Coexistent rheumatoid arthritis and gout: a case series and review of the literature. Clin Rheumatol. 2017;36:2835-2838 pubmed publisher
    ..Patient charts were reviewed and the 1987 ARA Revised Classification Criteria for RA and 1977 ARA Classification Criteria for gout were applied to each patient...
  49. Tatebe S, Sinicrope F, Kuo M. Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem Biophys Res Commun. 2002;290:1427-33 pubmed
    ..In this study, we reported that among the six members of the multidrug resistance protein gene (MRP1 to MRP6) family which encode membrane transporters for a diverse group of antitumor agents, expression of MRP1 and MRP3 but ..
  50. JanssenDuijghuijsen L, Van Norren K, Grefte S, Koppelman S, Lenaerts K, Keijer J, et al. Endurance Exercise Increases Intestinal Uptake of the Peanut Allergen Ara h 6 after Peanut Consumption in Humans. Nutrients. 2017;9: pubmed publisher
    ..We studied the uptake of the major allergen Ara h 6 following peanut consumption in an exercise model and compared this with changes in markers of intestinal ..
  51. Ángel Pereira D, Rocha Cabrera P, Cordovés Dorta L, Losada Castillo M, Blasco Alberto A, Abreu Reyes J. Spironolactone, a therapeutic alternative in the treatment of diffuse retinal pigment epitheliopathy. Arch Soc Esp Oftalmol. 2016;91:599-603 pubmed publisher
    ..Aldosterone receptor agonists (ARA) used for persistent forms of chronic central serous chorioretinopathy show encouraging results and could represent ..
  52. Zhao S, Tuerxun N, Chen R, Hao J. [Analysis of Therapy and Efficacy after Remission of Acute Myeloid Leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:1721-1724 pubmed publisher
    ..According to different consolidation therapy regimens, the patients were divided into 4 groups:1 ID-Ara-C group, 2 ID-Ara-C group, 3-4 ID-Ara-C group, allogeneic hematopoietic stem cell transplantation (allo-HSCT) group...
  53. Long B, Wang L, Zheng F, Lai S, Xu D, Hu Y, et al. Targeting GLI1 Suppresses Cell Growth and Enhances Chemosensitivity in CD34+ Enriched Acute Myeloid Leukemia Progenitor Cells. Cell Physiol Biochem. 2016;38:1288-302 pubmed publisher
    ..Furthermore, GANT61 enhanced the cytotoxicity of cytarabine (Ara-c) in primary CD34+ AML cells, indicating that inhibition of GLI1 could be a promising strategy to enhance ..
  54. Wesener D, Levengood M, Kiessling L. Comparing Galactan Biosynthesis in Mycobacterium tuberculosis and Corynebacterium diphtheriae. J Biol Chem. 2017;292:2944-2955 pubmed publisher
    ..The mAG is composed of lipid mycolic acids, and arabinofuranose (Araf) and galactofuranose (Galf) carbohydrate residues...
  55. van Soest S, Swart J, Tijmes N, Sandkuijl L, Rommers J, Bergen A. A locus for autosomal recessive pseudoxanthoma elasticum, with penetrance of vascular symptoms in carriers, maps to chromosome 16p13.1. Genome Res. 1997;7:830-4 pubmed
    Pseudoxanthoma elasticum (PXE) is a heritable systemic disorder characterized by calcification of the elastic fibers of the connective tissue...
  56. Wang M, Zhao S, Zhu P, Nie C, Ma S, Wang N, et al. Purification, characterization and immunomodulatory activity of water extractable polysaccharides from the swollen culms of Zizania latifolia. Int J Biol Macromol. 2018;107:882-890 pubmed publisher
    ..1%, respectively. ZLPs-W3 with triple helix conformation mainly consisted of Man, Rha, GalA, Glc, Gal and Ara in the molar ratio of 10.23:14.14:37.44:17.14:16.54:4.51...
  57. He W, Hu X, Jiang W, Liu R, Zhang D, Zhang J, et al. Rational Design of a New Self-Codelivery System from Redox-Sensitive Camptothecin-Cytarabine Conjugate Assembly for Effectively Synergistic Anticancer Therapy. Adv Healthc Mater. 2017;: pubmed publisher
    Herein, two careful selected anticancer drugs camptothecin (CPT) and cytarabine (Ara-C) with different biological action mechanisms and different water solubility are conjugated together through a glutathione (GSH) cleavable disulfide ..
  58. Beck K, Hayashi K, Dang K, Hayashi M, Boyd C. Analysis of ABCC6 (MRP6) in normal human tissues. Histochem Cell Biol. 2005;123:517-28 pubmed
    To determine the tissue distribution of the ABC transporter ABCC6 in normal human tissues, we analyzed tissue arrays for the presence of ABCC6 mRNA by in situ hybridization and ABCC6 protein by immunohistochemistry using the polyclonal ..
  59. Jiang Q, Matsuzaki Y, Li K, Uitto J. Transcriptional regulation and characterization of the promoter region of the human ABCC6 gene. J Invest Dermatol. 2006;126:325-35 pubmed
    b>ABCC6, a member of the adenosine 5'-triphosphate-binding cassette family of genes, encodes multidrug resistance-associated protein 6, a putative transmembrane transporter expressed primarily in the liver and to a significantly lower ..
  60. Ramsay M, Greenberg T, Lombard Z, Labrum R, Lubbe S, Aron S, et al. Spectrum of genetic variation at the ABCC6 locus in South Africans: Pseudoxanthoma elasticum patients and healthy individuals. J Dermatol Sci. 2009;54:198-204 pubmed publisher
    ..PXE is caused by mutations in ABCC6. To examine 54 unrelated South African PXE patients for ABCC6 PXE causing mutations...
  61. Noji Y, Inazu A, Higashikata T, Nohara A, Kawashiri M, Yu W, et al. Identification of two novel missense mutations (p.R1221C and p.R1357W) in the ABCC6 (MRP6) gene in a Japanese patient with pseudoxanthoma elasticum (PXE). Intern Med. 2004;43:1171-6 pubmed
    ..Recently, the ABCC6 (MRP6) gene was found to cause PXE. A defective type of ABCC6 gene (16pl3...
  62. Pan J, Lian Z, Wallett S, Wallet S, Feitelson M. The hepatitis B x antigen effector, URG7, blocks tumour necrosis factor alpha-mediated apoptosis by activation of phosphoinositol 3-kinase and beta-catenin. J Gen Virol. 2007;88:3275-85 pubmed
    ..Differential gene expression has previously revealed an upregulated gene, clone 7 (URG7), that conferred resistance to anti-Fas killing on HepG2X cells...
  63. Varatharajan S, Abraham A, Karathedath S, Ganesan S, Lakshmi K, Arthur N, et al. ATP-binding casette transporter expression in acute myeloid leukemia: association with in vitro cytotoxicity and prognostic markers. Pharmacogenomics. 2017;18:235-244 pubmed publisher
    ..There is limited data on the role of ABC transporter expression on in vitro sensitivity to cytarabine (Ara-C) and daunorubicin (Dnr) in primary AML cells...
  64. Hannivoort R, Dunning S, Vander Borght S, Schroyen B, Woudenberg J, Oakley F, et al. Multidrug resistance-associated proteins are crucial for the viability of activated rat hepatic stellate cells. Hepatology. 2008;48:624-34 pubmed publisher
    ..of Mrp3, Mrp4, Mdr1a, and Mdr1b but not the hepatocyte-specific transporters bile salt export pump, Mrp2, and Mrp6. Mrp1 protein staining correlated with desmin staining in livers from CCl(4)-treated rats...
  65. Sato N, Nakayama T, Mizutani Y, Yuzawa M. Novel mutations of ABCC6 gene in Japanese patients with Angioid streaks. Biochem Biophys Res Commun. 2009;380:548-53 pubmed publisher
    ..The ATP-binding cassette, sub-family C (CFTR/MRP), member 6 (ABCC6) is reported to be the causal gene for PXE, although there have been no reports on whether the ABCC6 gene is the ..
  66. Norberg B, Kleppe L, Andersson E, Thorsen A, Rosenlund G, Hamre K. Effects of dietary arachidonic acid on the reproductive physiology of female Atlantic cod (Gadus morhua L.). Gen Comp Endocrinol. 2017;250:21-35 pubmed publisher
    The present study was designed to investigate potential effects of arachidonic acid (ARA) on the reproductive physiology of female Atlantic cod (Gadus morhua L.)...
  67. Nitschke Y, Rutsch F. Genetics in arterial calcification: lessons learned from rare diseases. Trends Cardiovasc Med. 2012;22:145-9 pubmed publisher
    ..on the similarities of GACI, PXE, CALJA, and IBGC, it can be speculated that the underlying disease genes-ENPP1, ABCC6, NT5E, and SLC20A2, respectively-drive a cohesive molecular pathophysiology system modulated by ATP metabolism, ..
  68. Gorgels T, Teeling P, Meeldijk J, Nillesen S, van der Wal A, van Kuppevelt T, et al. Abcc6 deficiency in the mouse leads to calcification of collagen fibers in Bruch's membrane. Exp Eye Res. 2012;104:59-64 pubmed publisher
    ..The disease is caused by mutations in ABCC6. To learn more about PXE eye pathology, we analyzed Bruch's membrane (BM) of the eye of an Abcc6 knockout mouse...
  69. Ratajewski M, de Boussac H, Sachrajda I, Bacquet C, Kovacs T, Varadi A, et al. ABCC6 expression is regulated by CCAAT/enhancer-binding protein activating a primate-specific sequence located in the first intron of the gene. J Invest Dermatol. 2012;132:2709-17 pubmed publisher
    ..The disorder is due to loss-of-function mutations of the ABCC6 gene, but the pathophysiology of the disease is still not understood...
  70. Zhou J, Lu X, Tan T, Chng W. XIAP inhibition sensitizes acute myeloid leukemia cells response to TRAIL and chemotherapy through potentiated induction of pro-apoptotic machinery. Mol Oncol. 2017;: pubmed publisher
    ..Combination of RO-BIR2 with Ara-C had similar effect as the TRAIL combination...
  71. Plomp A, Bergen A, Florijn R, Terry S, Toonstra J, van Dijk M, et al. Pseudoxanthoma elasticum: Wide phenotypic variation in homozygotes and no signs in heterozygotes for the c.3775delT mutation in ABCC6. Genet Med. 2009;11:852-8 pubmed publisher
    ..recessive disorder of elastic tissue in the skin, eyes, and cardiovascular system, caused by mutations in the ABCC6 gene...
  72. Cao H, Miao C, Yan L, Tang P, Zhang L, Sun L. Polymorphisms at microRNA binding sites of Ara-C and anthracyclines-metabolic pathway genes are associated with outcome of acute myeloid leukemia patients. J Transl Med. 2017;15:235 pubmed publisher
    ..This study investigated the association between poly-miRTS of Ara-C/anthracycline metabolic pathways genes and the outcome of acute myeloid leukemia (AML) in Chinese patients after ..
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