ABCC1

Summary

Gene Symbol: ABCC1
Description: ATP binding cassette subfamily C member 1
Alias: ABC29, ABCC, GS-X, MRP, MRP1, multidrug resistance-associated protein 1, ATP-binding cassette transporter variant ABCC1delta-ex13, ATP-binding cassette transporter variant ABCC1delta-ex13&14, ATP-binding cassette transporter variant ABCC1delta-ex25, ATP-binding cassette transporter variant ABCC1delta-ex25&26, ATP-binding cassette, sub-family C (CFTR/MRP), member 1, LTC4 transporter, leukotriene C(4) transporter
Species: human
Products:     ABCC1

Top Publications

  1. Létourneau I, Deeley R, Cole S. Functional characterization of non-synonymous single nucleotide polymorphisms in the gene encoding human multidrug resistance protein 1 (MRP1/ABCC1). Pharmacogenet Genomics. 2005;15:647-57 pubmed
    The 190-kDa ATP-binding cassette (ABC) multidrug resistance protein 1 (MRP1) encoded by the MRP1/ABCC1 gene mediates the active cellular efflux of glucuronide, glutathione and sulfate conjugates...
  2. He X, Ee P, Coon J, Beck W. Alternative splicing of the multidrug resistance protein 1/ATP binding cassette transporter subfamily gene in ovarian cancer creates functional splice variants and is associated with increased expression of the splicing factors PTB and SRp20. Clin Cancer Res. 2004;10:4652-60 pubmed
    Overexpression of multidrug resistance protein 1 (MRP1) confers resistance to a range of chemotherapeutic agents in cell lines and could be involved in clinical drug resistance of some tumor types also...
  3. Vulsteke C, Lambrechts D, Dieudonne A, Hatse S, Brouwers B, van Brussel T, et al. Genetic variability in the multidrug resistance associated protein-1 (ABCC1/MRP1) predicts hematological toxicity in breast cancer patients receiving (neo-)adjuvant chemotherapy with 5-fluorouracil, epirubicin and cyclophosphamide (FEC). Ann Oncol. 2013;24:1513-25 pubmed publisher
    ..Twenty-six SNPs in 16 genes of interest, including the drug transporter gene ABCC1/MRP1, were selected based on a literature survey...
  4. Burger H, Foekens J, Look M, Meijer van Gelder M, Klijn J, Wiemer E, et al. RNA expression of breast cancer resistance protein, lung resistance-related protein, multidrug resistance-associated proteins 1 and 2, and multidrug resistance gene 1 in breast cancer: correlation with chemotherapeutic response. Clin Cancer Res. 2003;9:827-36 pubmed
    ..The aim of this study was to investigate whether expression of particular drug resistance genes in primary operable breast cancer correlates with response to first-line chemotherapy in advanced disease...
  5. Siedlinski M, Boezen H, Boer J, Smit H, Postma D. ABCC1 polymorphisms contribute to level and decline of lung function in two population-based cohorts. Pharmacogenet Genomics. 2009;19:675-84 pubmed publisher
    The ATP-binding cassette transporter ABCC1 [i.e...
  6. Grant C, Kurz E, Cole S, Deeley R. Analysis of the intron-exon organization of the human multidrug-resistance protein gene (MRP) and alternative splicing of its mRNA. Genomics. 1997;45:368-78 pubmed
    Overexpression of multidrug-resistance protein (MRP) and P-glycoprotein confers similar but not identical multidrug-resistance phenotypes...
  7. Mahjoubi F, Akbari S, Montazeri M, Moshyri F. MRP1 polymorphisms (T2684C, C2007T, C2012T, and C2665T) are not associated with multidrug resistance in leukemic patients. Genet Mol Res. 2008;7:1369-74 pubmed
    ..One of the most extensively studied genes involved in MDR is multidrug resistance protein 1 (MRP1)...
  8. Oselin K, Mrozikiewicz P, Gaikovitch E, Pähkla R, Roots I. Frequency of MRP1 genetic polymorphisms and their functional significance in Caucasians: detection of a novel mutation G816A in the human MRP1 gene. Eur J Clin Pharmacol. 2003;59:347-50 pubmed
    ..study was to determine the frequency of the G816A, T825C, T1684C, and G4002A genetic polymorphisms of the human MRP1 gene in 230 healthy Caucasians...
  9. Robbiani D, Finch R, Jager D, Muller W, Sartorelli A, Randolph G. The leukotriene C(4) transporter MRP1 regulates CCL19 (MIP-3beta, ELC)-dependent mobilization of dendritic cells to lymph nodes. Cell. 2000;103:757-68 pubmed
    ..skin to lymph nodes utilizes the leukotriene C(4) (LTC(4)) transporter multidrug resistance-associated protein 1 (MRP1)...

More Information

Publications87

  1. Conrad S, Kauffmann H, Ito K, Leslie E, Deeley R, Schrenk D, et al. A naturally occurring mutation in MRP1 results in a selective decrease in organic anion transport and in increased doxorubicin resistance. Pharmacogenetics. 2002;12:321-30 pubmed
    The human 190 kDa multidrug resistance protein, MRP1, is a polytopic membrane glycoprotein that confers resistance to a wide range of chemotherapeutic agents...
  2. Hodorova I, Rybarova S, Solar P, Vecanova J, Mihalik J, Bohus P, et al. Multidrug resistance proteins in renal cell carcinoma. Folia Biol (Praha). 2008;54:187-92 pubmed
    ..The aim of our study was to determine the expression of MDR1/Pgp, MRP1 and LRP in 47 samples of renal cell carcinomas using immunohistochemical assay...
  3. Larbcharoensub N, Leopairat J, Sirachainan E, Narkwong L, Bhongmakapat T, Rasmeepaisarn K, et al. Association between multidrug resistance-associated protein 1 and poor prognosis in patients with nasopharyngeal carcinoma treated with radiotherapy and concurrent chemotherapy. Hum Pathol. 2008;39:837-45 pubmed publisher
    ..In this study, we investigated 3 ABC multidrug transporters including MDR1, MRP1, and BCRP for their potential as prognostic indicators in patients with NPC...
  4. Semsei A, Erdelyi D, Ungvári I, Cságoly E, Hegyi M, Kiszel P, et al. ABCC1 polymorphisms in anthracycline-induced cardiotoxicity in childhood acute lymphoblastic leukaemia. Cell Biol Int. 2012;36:79-86 pubmed publisher
    ..b>ABCC1 [ATP-binding cassette, sub-family C, member 1; also denoted as MRP1 (multidrug resistance-associated protein 1)] ..
  5. Roundhill E, Burchill S. Detection and characterisation of multi-drug resistance protein 1 (MRP-1) in human mitochondria. Br J Cancer. 2012;106:1224-33 pubmed publisher
    Overexpression of plasma membrane multi-drug resistance protein 1 (MRP-1) can lead to multidrug resistance...
  6. Budulac S, Postma D, Hiemstra P, Kunz L, Siedlinski M, Smit H, et al. Multidrug resistance-associated protein-1 (MRP1) genetic variants, MRP1 protein levels and severity of COPD. Respir Res. 2010;11:60 pubmed publisher
    Multidrug resistance-associated protein-1 (MRP1) protects against oxidative stress and toxic compounds generated by cigarette smoking, which is the main risk factor for chronic obstructive pulmonary disease (COPD)...
  7. Lacueva J, Perez Ramos M, Soto J, Oliver I, Andrada E, Medrano J, et al. Multidrug resistance-associated protein (MRP1) gene is strongly expressed in gastric carcinomas. Analysis by immunohistochemistry and real-time quantitative RT-PCR. Histopathology. 2005;46:389-95 pubmed
    To assess MRP1 protein and MRP1 mRNA levels in gastric carcinomas and in non-neoplastic mucosa remote from the tumours. MRP1 gene expression may play a role in the complex pattern of chemoresistance present in gastric carcinomas...
  8. Cole S, Bhardwaj G, Gerlach J, Mackie J, Grant C, Almquist K, et al. Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science. 1992;258:1650-4 pubmed
    ..1. Reversion to drug sensitivity was associated with loss of gene amplification and a marked decrease in mRNA expression. The mRNA encodes a member of the ATP-binding cassette transmembrane transporter superfamily. ..
  9. Conrad S, Kauffmann H, Ito K, Deeley R, Cole S, Schrenk D. Identification of human multidrug resistance protein 1 (MRP1) mutations and characterization of a G671V substitution. J Hum Genet. 2001;46:656-63 pubmed
    The multidrug resistance protein 1 (MRP1) belonging to the ATP-binding cassette (ABC) superfamily of transport proteins can confer resistance to multiple natural product drugs and methotrexate in human tumor cells...
  10. Tatebe S, Sinicrope F, Kuo M. Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem Biophys Res Commun. 2002;290:1427-33 pubmed
    ..In this study, we reported that among the six members of the multidrug resistance protein gene (MRP1 to MRP6) family which encode membrane transporters for a diverse group of antitumor agents, expression of MRP1 and ..
  11. Lee S, Lee M, Lee J, Kim S, Kang R, Choi M, et al. MRP1 polymorphisms associated with citalopram response in patients with major depression. J Clin Psychopharmacol. 2010;30:116-25 pubmed publisher
    Multidrug resistance protein 1 (MRP1, ABCC1) transports antidepressive agents in the endothelial cells of the blood-brain barrier. Therefore, polymorphisms in the MRP1 gene may affect the treatment response of antidepressants...
  12. Cho S, Lu M, He X, Ee P, Bhat U, Schneider E, et al. Notch1 regulates the expression of the multidrug resistance gene ABCC1/MRP1 in cultured cancer cells. Proc Natl Acad Sci U S A. 2011;108:20778-83 pubmed publisher
    ..To test whether Notch1 is involved in the expression of multidrug resistance-associated protein 1 (ABCC1/MRP1; herein referred to as ABCC1), we measured N1(IC) and presenilin 1 (PSEN1), the catalytic subunit of ?-..
  13. Manohar C, Bray J, Salwen H, Madafiglio J, Cheng A, Flemming C, et al. MYCN-mediated regulation of the MRP1 promoter in human neuroblastoma. Oncogene. 2004;23:753-62 pubmed
    In the childhood cancer neuroblastoma (NB), the level of expression of the multidrug resistance-associated protein (MRP1) gene is strongly correlated with expression of the MYCN oncogene in primary NB tumors, suggesting that MRP1 may be a ..
  14. Yin J, Huang Q, Yang Y, Zhang J, Zhong M, Zhou H, et al. Characterization and analyses of multidrug resistance-associated protein 1 (MRP1/ABCC1) polymorphisms in Chinese population. Pharmacogenet Genomics. 2009;19:206-16 pubmed publisher
    To explore the distribution frequencies of four common single nucleotide polymorphisms (SNPs) of MRP1/ABCC1 in a mainland Chinese population and investigate whether these SNPs affect the expression and function of the MRP1/ABCC1...
  15. Mafficini A, Ortombina M, Sermet Gaudelius I, Lebecque P, Leal T, Iansa P, et al. Impact of polymorphism of Multidrug Resistance-associated Protein 1 (ABCC1) gene on the severity of cystic fibrosis. J Cyst Fibros. 2011;10:228-33 pubmed publisher
    ..16:g.15983174C>G) functional polymorphism of Multidrug Resistance-associated Protein 1 (ABCC1) promoter has been reported which influences ABCC1 expression including inflammatory related events...
  16. Kourti M, Vavatsi N, Gombakis N, Sidi V, Tzimagiorgis G, Papageorgiou T, et al. Expression of multidrug resistance 1 (MDR1), multidrug resistance-related protein 1 (MRP1), lung resistance protein (LRP), and breast cancer resistance protein (BCRP) genes and clinical outcome in childhood acute lymphoblastic leukemia. Int J Hematol. 2007;86:166-73 pubmed
    The aim of this prospective study was to analyze the expression of messenger RNA of genes, such as MDR1, MRP1, BCRP, and LRP, implicated in the mechanism of multidrug resistance (MDR) in relation to the response to induction chemotherapy ..
  17. Iram S, Cole S. Expression and function of human MRP1 (ABCC1) is dependent on amino acids in cytoplasmic loop 5 and its interface with nucleotide binding domain 2. J Biol Chem. 2011;286:7202-13 pubmed publisher
    Multidrug resistance protein 1 (MRP1) is an ATP-binding cassette transporter that effluxes drugs and organic anions across the plasma membrane...
  18. Faggad A, Darb Esfahani S, Wirtz R, Sinn B, Sehouli J, Könsgen D, et al. Expression of multidrug resistance-associated protein 1 in invasive ovarian carcinoma: implication for prognosis. Histopathology. 2009;54:657-66 pubmed publisher
    ..The aim of this study was to investigate the expression of multidrug resistance-associated protein 1 (MRP1) and to assess the possible associations with clinicopathological variables and patient outcome in primary ovarian ..
  19. Hipfner D, Almquist K, Leslie E, Gerlach J, Grant C, Deeley R, et al. Membrane topology of the multidrug resistance protein (MRP). A study of glycosylation-site mutants reveals an extracytosolic NH2 terminus. J Biol Chem. 1997;272:23623-30 pubmed
    Multidrug resistance protein, MRP, is a 190-kDa integral membrane phosphoglycoprotein that belongs to the ATP-binding cassette superfamily of transport proteins and is capable of conferring resistance to multiple chemotherapeutic agents...
  20. Rajagopal A, Simon S. Subcellular localization and activity of multidrug resistance proteins. Mol Biol Cell. 2003;14:3389-99 pubmed
    ..The multidrug resistance protein 1 (MRP1), P-glycoprotein, and the breast cancer resistance protein are each present in a perinuclear region positive for ..
  21. Ramaen O, Leulliot N, Sizun C, Ulryck N, Pamlard O, Lallemand J, et al. Structure of the human multidrug resistance protein 1 nucleotide binding domain 1 bound to Mg2+/ATP reveals a non-productive catalytic site. J Mol Biol. 2006;359:940-9 pubmed
    Human multidrug resistance protein 1 (MRP1) is a membrane protein that belongs to the ATP-binding cassette (ABC) superfamily of transport proteins...
  22. Yin J, Han L, Huang Q, Xu X, Zhou H, Liu Z. ABCC1 polymorphism Arg723Gln (2168G> A) is associated with lung cancer susceptibility in a Chinese population. Clin Exp Pharmacol Physiol. 2011;38:632-7 pubmed publisher
    1. In a previous in vitro study, we showed that the Arg723Gln (2168G > A) polymorphism significantly ABCC1-induced multidrug resistance...
  23. Zhang D, Cole S, Deeley R. Identification of an amino acid residue in multidrug resistance protein 1 critical for conferring resistance to anthracyclines. J Biol Chem. 2001;276:13231-9 pubmed
    Murine multidrug resistance protein 1 (mrp1), unlike human MRP1, does not confer resistance to anthracyclines...
  24. Beedholm Ebsen R, van de Wetering K, Hardlei T, Nexø E, Borst P, Moestrup S. Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin. Blood. 2010;115:1632-9 pubmed publisher
    ..cellular gene silencing showed a role in cellular Cbl efflux of the ATP-binding cassette (ABC)-drug transporter, ABCC1, alias multidrug resistance protein 1 (MRP1), which is present in the basolateral membrane of intestinal ..
  25. Fernetti C, Pascolo L, Podda E, Gennaro R, Stebel M, Tiribelli C. Preparation of an antibody recognizing both human and rodent MRP1. Biochem Biophys Res Commun. 2001;288:1064-8 pubmed
    Based on the high level of identity among human, mouse, and rat MRP1 protein sequence, we produced a specific polyclonal antibody (MRP1-A23) against a synthetic polypeptide covering the C-terminus of the human protein...
  26. Aukunuru J, Sunkara G, Bandi N, Thoreson W, Kompella U. Expression of multidrug resistance-associated protein (MRP) in human retinal pigment epithelial cells and its interaction with BAPSG, a novel aldose reductase inhibitor. Pharm Res. 2001;18:565-72 pubmed
    ..Western blots and RT-PCR were used to obtain biochemical evidence for MRP1. The influence of MRP inhibitors on BAPSG accumulation and efflux in ARPE-19 cells was determined to understand its ..
  27. Qin L, Zheng J, Grant C, Jia Z, Cole S, Deeley R. Residues responsible for the asymmetric function of the nucleotide binding domains of multidrug resistance protein 1. Biochemistry. 2008;47:13952-65 pubmed publisher
    ..In many ABC proteins, the NBSs are thought to be functionally equivalent. However, this is not the case for ABCC proteins, such as MRP1, in which NBS1 containing the Walker A and B motifs from the N-proximal NBD1 typically binds ..
  28. Obata H, Yahata T, Quan J, Sekine M, Tanaka K. Association between single nucleotide polymorphisms of drug resistance-associated genes and response to chemotherapy in advanced ovarian cancer. Anticancer Res. 2006;26:2227-32 pubmed
    ..SNPs were analyzed for MDR1, MRP1, MRP2 and LRP in 60 advanced ovarian cancer patients...
  29. Woillard J, Debord J, Benz de Bretagne I, Saint Marcoux F, Turlure P, Girault S, et al. A Time-Dependent Model Describes Methotrexate Elimination and Supports Dynamic Modification of MRP2/ABCC2 Activity. Ther Drug Monit. 2017;39:145-156 pubmed publisher
    ..025 ± 0.008, P = 0.00443). Self-inhibition of the MRP2-dependent secretion of MTX is a plausible explanation for the time-dependent PKs of this drug. Additional studies specifically designed to evaluate this hypothesis are required. ..
  30. Yang X, Ma Z, Zhou S, Weng Y, Lei H, Zeng S, et al. Multiple Drug Transporters Are Involved in Renal Secretion of Entecavir. Antimicrob Agents Chemother. 2016;60:6260-70 pubmed publisher
    ..Therefore, the renal uptake of ETV is likely mediated by OAT1/3 and OCT2 while the efflux is mediated by MATEs, MDR1, and MRP2, and OCTN1/2 may participate in both renal secretion and reabsorption. ..
  31. Campos B, Altenburger R, Gómez C, Lacorte S, Pina B, Barata C, et al. First evidence for toxic defense based on the multixenobiotic resistance (MXR) mechanism in Daphnia magna. Aquat Toxicol. 2014;148:139-51 pubmed publisher
    ..magna. We cloned putatively MXR-related partial abcb1, abcc1/3, abcc4 and abcc5 coding sequences; respective transcripts were constitutively expressed in different D...
  32. Meloni I, Rubegni P, De Aloe G, Bruttini M, Pianigiani E, Cusano R, et al. Pseudoxanthoma elasticum: Point mutations in the ABCC6 gene and a large deletion including also ABCC1 and MYH11. Hum Mutat. 2001;18:85 pubmed
    ..hemizygosity of marker D16S405 allowed us to detect a submicroscopic deletion of at least 900 kb involving ABCC6, ABCC1, and MYH11...
  33. Sharom F. ABC multidrug transporters: structure, function and role in chemoresistance. Pharmacogenomics. 2008;9:105-27 pubmed
    ..multidrug efflux pumps are known to be responsible for chemoresistance; P-glycoprotein (ABCB1), MRP1 (ABCC1) and ABCG2 (BCRP)...
  34. Kuss B, O Neill G, Eyre H, Doggett N, Callen D, Davey R. ARA, a novel ABC transporter, is located at 16p13.1, is deleted in inv(16) leukemias, and is shown to be expressed in primitive hematopoietic precursors. Genomics. 1998;51:455-8 pubmed
    ..transporters are a large superfamily of proteins that include the multidrug resistance proteins, P-glycoprotein and MRP (multidrug resistance protein)...
  35. Abraham E, Sterling K, Kim R, Salikhova A, Huffman H, Crockett M, et al. Erythrocyte membrane ATP binding cassette (ABC) proteins: MRP1 and CFTR as well as CD39 (ecto-apyrase) involved in RBC ATP transport and elevated blood plasma ATP of cystic fibrosis. Blood Cells Mol Dis. 2001;27:165-80 pubmed
    ..the cystic fibrosis transmembrane conductance regulator (CFTR) and the multidrug resistance-associated protein (MRP1), respectively, constitute significant proteins in the red blood cell membrane...
  36. Valdez B, Brammer J, Li Y, Murray D, Teo E, Liu Y, et al. Romidepsin enhances the cytotoxicity of fludarabine, clofarabine and busulfan combination in malignant T-cells. Leuk Res. 2016;47:100-8 pubmed publisher
    ..The SAPK/JNK stress pathway was activated. A novel finding was the down-regulation of the drug transporter MRP1. We propose the following mechanisms of synergism: Flu, Clo and Rom induce histone modifications and chromatin ..
  37. Sirotnak F, Wendel H, Bornmann W, Tong W, Miller V, Scher H, et al. Co-administration of probenecid, an inhibitor of a cMOAT/MRP-like plasma membrane ATPase, greatly enhanced the efficacy of a new 10-deazaaminopterin against human solid tumors in vivo. Clin Cancer Res. 2000;6:3705-12 pubmed
    ..ATPase resembling the canicular multispecific organic anion transporter/multidrug resistance-related protein (MRP) family of ATP binding cassette transporters...
  38. Li J, Wu X, Gong J, Yang J, Leng J, Chen Q, et al. Vascular endothelial growth factor induces multidrug resistance-associated protein 1 overexpression through phosphatidylinositol-3-kinase /protein kinase B signaling pathway and transcription factor specificity protein 1 in BGC823 cell line. Acta Biochim Biophys Sin (Shanghai). 2013;45:656-63 pubmed publisher
    ..But the roles of the MDR-associated protein MRP1 in MDR remain poorly understood...
  39. Zhang Y, Wang Y, Gupta P, Chen Z. Multidrug Resistance Proteins (MRPs) and Cancer Therapy. AAPS J. 2015;17:802-12 pubmed publisher
    ..This review article summarizes the structure, distribution, and physiological as well as pharmacological function of MRP1-MRP9 in cancer chemotherapy. Several novel modulators targeting MRPs in cancer therapy are also discussed.
  40. Létourneau I, Slot A, Deeley R, Cole S. Mutational analysis of a highly conserved proline residue in MRP1, MRP2, and MRP3 reveals a partially conserved function. Drug Metab Dispos. 2007;35:1372-9 pubmed
    The ATP-binding cassette multidrug resistance protein 1 MRP1 (ABCC1) mediates the cellular efflux of organic anions including conjugated metabolites, chemotherapeutic agents, and toxicants...
  41. Wang Z, Zhou Q, Kruh G, Gallo J. Dose-dependent disposition of methotrexate in Abcc2 and Abcc3 gene knockout murine models. Drug Metab Dispos. 2011;39:2155-61 pubmed publisher
    ..The findings confirmed that both Abcc2 and Abcc3 significantly influenced the PK properties of MTX, and depending on the MTX dose and strain, alternate elimination pathways were elicited and saturable...
  42. Coates B, Siegfried B. Linkage of an ABCC transporter to a single QTL that controls Ostrinia nubilalis larval resistance to the Bacillus thuringiensis Cry1Fa toxin. Insect Biochem Mol Biol. 2015;63:86-96 pubmed publisher
    ..nubilalis genome region encoding an abcc2 transporter is in proximity to a single QTL involved in the inheritance of Cry1F resistance, and will assist in the future identification the mutation(s) involved with this phenotype. ..
  43. Scotto K. Transcriptional regulation of ABC drug transporters. Oncogene. 2003;22:7496-511 pubmed
    ..However, the identification of MRP1, another member of the ABC drug transporter family, led to the realization that the multidrug resistance (MDR) ..
  44. Sharma R, Awasthi Y, Yang Y, Sharma A, Singhal S, Awasthi S. Energy dependent transport of xenobiotics and its relevance to multidrug resistance. Curr Cancer Drug Targets. 2003;3:89-107 pubmed
    ..to the two major families of efflux pumps, P-glycoprotein (Pgp) and multidrug resistance associated proteins (MRP), which belong to the ATP-binding cassette (ABC) super family...
  45. Yokooji T. [Role of ABC efflux transporters in the oral bioavailability and drug-induced intestinal toxicity]. Yakugaku Zasshi. 2013;133:815-22 pubmed
    ..which occurs in some disease states, increased intestinal accumulation and toxicity of methotrexate, an MRP substrate, because of the suppression of MRP function by high plasma concentrations of conjugated bilirubin...
  46. Clark P, Al Ahmad A, Qian T, Zhang R, Wilson H, Weichert J, et al. Analysis of Cancer-Targeting Alkylphosphocholine Analogue Permeability Characteristics Using a Human Induced Pluripotent Stem Cell Blood-Brain Barrier Model. Mol Pharm. 2016;13:3341-9 pubmed publisher
    ..5) and BBB-permeable diazepam (170 ± 29). Only the fluorescent APC analogues (CLR1501, CLR1502) underwent BCRP and MRP polarized drug efflux transport in the brain-to-blood direction of the BBB model, and this efflux can be ..
  47. Engström K, Love T, WATSON G, Zareba G, Yeates A, Wahlberg K, et al. Polymorphisms in ATP-binding cassette transporters associated with maternal methylmercury disposition and infant neurodevelopment in mother-infant pairs in the Seychelles Child Development Study. Environ Int. 2016;94:224-229 pubmed publisher
    ..Genotyping for fifteen SNPs in ABCC1, ABCC2 and ABCB1 was performed for the mothers...
  48. Susukida T, Sekine S, Ogimura E, Aoki S, Oizumi K, Horie T, et al. Basal efflux of bile acids contributes to drug-induced bile acid-dependent hepatocyte toxicity in rat sandwich-cultured hepatocytes. Toxicol In Vitro. 2015;29:1454-63 pubmed publisher
    ..However, basal efflux transporters, including multidrug resistance-associated proteins (MRP or Mrp) 3 and 4, also participate in BA efflux...
  49. Fernandes E Silva E, Figueira F, Lettnin A, Carrett Dias M, Filgueira D, Kalil S, et al. C-Phycocyanin: Cellular targets, mechanisms of action and multi drug resistance in cancer. Pharmacol Rep. 2018;70:75-80 pubmed publisher
    ..We also propose future analyses of the interaction between C-PC and drug extrusion proteins, such as ABCB1 and ABCC1, using in silico and in vitro studies.
  50. Evers R, Kool M, van Deemter L, Janssen H, Calafat J, Oomen L, et al. Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA. J Clin Invest. 1998;101:1310-9 pubmed
    ..amino acid sequence of cMOAT is 49% identical to that of the human multidrug resistance- associated protein (MRP) MRP1, and cMOAT and MRP1 are members of the same sub-family of adenine nucleotide binding cassette transporters...
  51. Oda Y, Saito T, Tateishi N, Ohishi Y, Tamiya S, Yamamoto H, et al. ATP-binding cassette superfamily transporter gene expression in human soft tissue sarcomas. Int J Cancer. 2005;114:854-62 pubmed
    ..In 86 cases of surgically resected soft tissue sarcoma, intrinsic mRNA levels of MDR1, MRP1, MRP2 and MRP3 were assessed using a quantitative reverse transcriptase-PCR (RT-PCR) method...
  52. Straka E, Ellinger I, Balthasar C, Scheinast M, Schatz J, Szattler T, et al. Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters. Toxicology. 2016;340:34-42 pubmed publisher
    ..Mercury conjugated to glutathione (GSH) is effluxed via MRP1 localized to the basal side of the STB...
  53. den Boer M, Kapaun P, Pieters R, Kazemier K, Janka Schaub G, Veerman A. Myeloid antigen co-expression in childhood acute lymphoblastic leukaemia: relationship with in vitro drug resistance. Br J Haematol. 1999;105:876-82 pubmed
    ..P-glycoprotein (P-gp), multidrug resistance-associated protein (MRP), major vault protein/lung resistance protein (LRP) and the intracellular daunorubicin concentration were studied ..
  54. Geisler M, Girin M, Brandt S, Vincenzetti V, Plaza S, Paris N, et al. Arabidopsis immunophilin-like TWD1 functionally interacts with vacuolar ABC transporters. Mol Biol Cell. 2004;15:3393-405 pubmed
    ..binds to a motif of AtMRP1 that resembles calmodulin-binding motifs; and calmodulin binding to the C-terminus of MRP1 was verified...
  55. Damiani D, Michelutti A, Michieli M, Masolini P, Stocchi R, Geromin A, et al. P-glycoprotein, lung resistance-related protein and multidrug resistance-associated protein in de novo adult acute lymphoblastic leukaemia. Br J Haematol. 2002;116:519-27 pubmed
    P-glycoprotein (P-gp), lung resistance-related protein (LRP) and multidrug resistance-associated protein (MRP) expression, and blast cell intracellular daunorubicin accumulation (IDA) were evaluated in 95 previously untreated cases of ..
  56. Lima J, Zhang S, Grant A, Shao L, Tantisira K, Allayee H, et al. Influence of leukotriene pathway polymorphisms on response to montelukast in asthma. Am J Respir Crit Care Med. 2006;173:379-85 pubmed
    ..Twenty-eight SNPs in the ALOX5, LTA4H, LTC4S, MRP1, and cysLT1R genes, and an ALOX5 repeat polymorphism were successfully typed...
  57. Colombo S, Soranzo N, Rotger M, Sprenger R, Bleiber G, Furrer H, et al. Influence of ABCB1, ABCC1, ABCC2, and ABCG2 haplotypes on the cellular exposure of nelfinavir in vivo. Pharmacogenet Genomics. 2005;15:599-608 pubmed
    ..protease inhibitor nelfinavir is substrate of polyspecific drug transporters encoded by ABCB1 (P-glycoprotein), ABCC1 (MRP1) and ABCC2 (MRP2), and an inhibitor of BCRP, encoded by ABCG2...
  58. Ohashi R, Kawahara K, Namimatsu S, Okamura R, Igarashi T, Sugitani I, et al. Expression of MRP1 and ABCG2 is associated with adverse clinical outcomes of papillary thyroid carcinoma with a solid component. Hum Pathol. 2017;67:11-17 pubmed publisher
    ..Immunohistochemical expression of CSC markers ABCG2 and MRP1, and HBME1 and CK19 was compared between SC and PC within each tumor in association with clinicopathological ..
  59. Mészaros P, Klappe K, Hummel I, Hoekstra D, Kok J. Function of MRP1/ABCC1 is not dependent on cholesterol or cholesterol-stabilized lipid rafts. Biochem J. 2011;437:483-91 pubmed publisher
    MRP1 (multidrug-resistance-related protein 1)/ABCC1 (ATP-binding cassette transporter C1) has been localized in cholesterol-enriched lipid rafts, which suggests a role for these lipid rafts and/or cholesterol in MRP1 function...
  60. Mondaca Navarro B, Ávila Villa L, González Córdova A, López Cervantes J, Sánchez Machado D, Campas Baypoli O, et al. Antioxidant and chelating capacity of Maillard reaction products in amino acid-sugar model systems: applications for food processing. J Sci Food Agric. 2017;97:3522-3529 pubmed publisher
    Maillard reaction products (MRP) have gained increasing interest owing to their both positive and negative effects on human health...
  61. Ito M, Guffanti A, Krulwich T. Mrp-dependent Na(+)/H(+) antiporters of Bacillus exhibit characteristics that are unanticipated for completely secondary active transporters. FEBS Lett. 2001;496:117-20 pubmed
    The Na(+)/H(+) antiport activity encoded by the seven-gene mrp operons of Bacillus subtilis and alkaliphilic Bacillus pseudofirmus OF4 were cloned into a low copy plasmid, were expressed in several Escherichia coli mutant strains and ..
  62. Kok J, Veldman R, Klappe K, Koning H, Filipeanu C, Muller M. Differential expression of sphingolipids in MRP1 overexpressing HT29 cells. Int J Cancer. 2000;87:172-8 pubmed
    ..In addition, ceramide, a lipid messenger molecule involved in apoptosis-related signal transduction processes, was much more abundant in HT29(col) cells, which is indicative of a stress response...
  63. Marques D, Sandrini J, Boyle R, Marins L, Trindade G. Relationships between multidrug resistance (MDR) and stem cell markers in human chronic myeloid leukemia cell lines. Leuk Res. 2010;34:757-62 pubmed publisher
    ..The promoter regions of ABCB1, ABCG2 and ABCC1 genes contain binding sites for the Oct-4 transcripton factor, which is also considered a marker of tumor stem ..
  64. Miller D, Fontain M, Kolar C, Lawson T. The expression of multidrug resistance-associated protein (MRP) in pancreatic adenocarcinoma cell lines. Cancer Lett. 1996;107:301-6 pubmed
    The presence of P-glycoprotein (P-gp) and multiple drug resistance-associated protein (MRP) was examined in four human pancreatic adenocarcinoma cell lines (PANC-1, BxPC-3, AsPC-1, and Capan-1)...
  65. Sun J, Zhang H, Li L, Yu L, Fu L. MicroRNA-9 limits hepatic fibrosis by suppressing the activation and proliferation of hepatic stellate cells by directly targeting MRP1/ABCC1. Oncol Rep. 2017;37:1698-1706 pubmed publisher
    ..and activated HSCs as detected by qRT-PCR; whereas, expression of multidrug resistance?associated protein 1 (MRP1/ABCC1) was upregulated in the fibrotic liver tissues and activated HSCs...
  66. Marin E, Leonhardt N, Vavasseur A, Forestier C. Cloning of AtMRP1, an Arabidopsis thaliana cDNA encoding a homologue of the mammalian multidrug resistance-associated protein. Biochim Biophys Acta. 1998;1369:7-13 pubmed
    ..The cDNA is 5.5 kb long and contains an ORF encoding a 1623 amino acids protein. This sequence is the first MRP-like protein found in plants.
  67. Hirose M, Kuroda Y. p53 may mediate the mdr-1 expression via the WT1 gene in human vincristine-resistant leukemia/lymphoma cell lines. Cancer Lett. 1998;129:165-71 pubmed
    ..of the expression of the multidrug resistance gene (mdr-1) and the multidrug resistance-associated protein gene (mrp), we investigated if p53, WT1, RB, C-myc, N-myc, cyclin D1, p16INK4 (p16) are involved in the acquirement of ..
  68. Van Itallie C, Tietgens A, Aponte A, Gucek M, Cartagena Rivera A, Chadwick R, et al. MARCKS-related protein regulates cytoskeletal organization at cell-cell and cell-substrate contacts in epithelial cells. J Cell Sci. 2018;131: pubmed publisher
    ..performed proximity-dependent biotinylation (BioID) of occludin and found that tagging of MARCKS-related protein (MRP; also known as MARCKSL1) increased ∼20-fold following IFN/TNF administration...
  69. Molinari A, Toccacieli L, Calcabrini A, Diociaiuti M, Cianfriglia M, Arancia G. Induction of P-glycoprotein expression on the plasma membrane of human melanoma cells. Anticancer Res. 2000;20:2691-6 pubmed
    ..human melanoma cells (M14) intrinsically express significant amounts of multidrug resistance-related protein (MRP1) and P-glycoprotein (P-gp) in the Golgi apparatus, but do not express these drug transporters on the plasma ..
  70. Zhao Y, Yu L, Wang Q, Lou F, Pu J. [The relationship between expression of lung resistance-related protein gene or multidrug resistance-associated protein gene and prognosis in newly diagnosed acute leukemia]. Zhonghua Nei Ke Za Zhi. 2002;41:183-5 pubmed
    To evaluate the relationship between the expression of lung resistance-related protein (lrp) gene or multidrug resistance-associated protein (mrp) gene and prognosis in untreated acute leukemia (AL) patients.
  71. Yabuuchi H, Takayanagi S, Yoshinaga K, Taniguchi N, Aburatani H, Ishikawa T. ABCC13, an unusual truncated ABC transporter, is highly expressed in fetal human liver. Biochem Biophys Res Commun. 2002;299:410-7 pubmed
    ..The amino acid sequence corresponding to putative membrane-spanning domains was remarkably similar to ABCC1, ABCC2, ABCC3, and ABCC6...
  72. Mason D, Mallampalli M, Huyer G, Michaelis S. A region within a lumenal loop of Saccharomyces cerevisiae Ycf1p directs proteolytic processing and substrate specificity. Eukaryot Cell. 2003;2:588-98 pubmed
    Ycf1p, a member of the yeast multidrug resistance-associated protein (MRP) subfamily of ATP-binding cassette proteins, is a vacuolar membrane transporter that confers resistance to a variety of toxic substances such as cadmium and ..
  73. Mookerjee Basu J, Mookerjee A, Banerjee R, Saha M, Singh S, Naskar K, et al. Inhibition of ABC transporters abolishes antimony resistance in Leishmania Infection. Antimicrob Agents Chemother. 2008;52:1080-93 pubmed
    ..donovani induces the upregulation of multidrug resistance-associated protein 1 (MRP1) and permeability glycoprotein (P-gp) in host cells, resulting in a nonaccumulation of intracellular Sb following ..
  74. Zhou Q, Ye M, Lu Y, Zhang H, Chen Q, Huang S, et al. Curcumin Improves the Tumoricidal Effect of Mitomycin C by Suppressing ABCG2 Expression in Stem Cell-Like Breast Cancer Cells. PLoS ONE. 2015;10:e0136694 pubmed publisher
    ..sensitized BCSCs through a reduction in the expression of ATP-binding cassette (ABC) transporters ABCG2 and ABCC1. We demonstrated that fumitremorgin C, a selective ABCG2 inhibitor, reduced BCSC survival to a similar degree as ..
  75. Maguire A, Plunkett S, Papot S, Clynes M, O CONNOR R, Touhey S. Synthesis of indomethacin analogues for evaluation as modulators of MRP activity. Bioorg Med Chem. 2001;9:745-62 pubmed
    ..Synthesis of a range of indomethacin analogues, required for investigation in combination toxicity assays, bearing both N-benzyl and N-benzoyl groups, is described...
  76. Ren X, Furukawa T, Haraguchi M, Sumizawa T, Aoki S, Kobayashi M, et al. Function of the ABC signature sequences in the human multidrug resistance protein 1. Mol Pharmacol. 2004;65:1536-42 pubmed
    Human multidrug resistance protein 1 (MRP1) is a membrane ATP-binding cassette transporter that confers multidrug resistance to tumor cells by effluxing intracellular drugs in an ATP-dependent manner...
  77. Kamisako T, Ogawa H. Alteration of the expression of adenosine triphosphate-binding cassette transporters associated with bile acid and cholesterol transport in the rat liver and intestine during cholestasis. J Gastroenterol Hepatol. 2005;20:1429-34 pubmed
    ..The purpose of the present study was to evaluate intestinal and hepatic adenosine triphosphate-binding cassette transporter expressions during cholestasis...
  78. Kaliszczak M, Antonow D, Patel K, Howard P, Jodrell D, Thurston D, et al. Optimization of the antitumor activity of sequence-specific pyrrolobenzodiazepine derivatives based on their affinity for ABC transporters. AAPS J. 2010;12:617-27 pubmed publisher
    ..four dimers and 12 monomers) with the three major human ATP-binding cassette (ABC) transporters (P-gp, ABCG2, and MRP1)...