ABCB1

Summary

Gene Symbol: ABCB1
Description: ATP-binding cassette, sub-family B (MDR/TAP), member 1
Alias: ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1, P-glycoprotein 1, colchicin sensitivity, doxorubicin resistance, multidrug resistance protein 1
Species: human

Top Publications

  1. ncbi A "silent" polymorphism in the MDR1 gene changes substrate specificity
    Chava Kimchi-Sarfaty
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Science 315:525-8. 2007
  2. pmc Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    S Hoffmeyer
    Epidauros Biotechnology, Pharmacogenetics Laboratory, Am Neuland 1, D 82347 Bernried, Germany
    Proc Natl Acad Sci U S A 97:3473-8. 2000
  3. pmc Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1
    Benjamin Boyerinas
    Feinberg School of Medicine, Division Hematology Oncology, Northwestern University, Chicago, IL 60611, USA
    Int J Cancer 130:1787-97. 2012
  4. ncbi Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief
    D Campa
    Department of Biology, University of Pisa, Pisa, Italy
    Clin Pharmacol Ther 83:559-66. 2008
  5. ncbi Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study
    Jacques Fellay
    Division of Infectious Diseases, University Hospital of Lausanne, Lausanne, Switzerland
    Lancet 359:30-6. 2002
  6. pmc Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study
    Vibeke Andersen
    Medical Department, Viborg Regional Hospital, DK 8800 Viborg, Denmark
    BMC Cancer 9:407. 2009
  7. ncbi Isolation and expression of a complementary DNA that confers multidrug resistance
    P Gros
    Nature 323:728-31. 1986
  8. ncbi ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals
    Janet K Coller
    Discipline of Pharmacology, School of Medical Sciences, The University of Adelaide, and Department of Clinical Pharmacology, Royal Adelaide Hospital, SA, Australia
    Clin Pharmacol Ther 80:682-90. 2006
  9. pmc Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics
    Federico Innocenti
    The University of Chicago, Chicago, IL 60637, USA
    J Clin Oncol 27:2604-14. 2009
  10. doi Effects of CYP2C19, MDR1, and interleukin 1-B gene variants on the eradication rate of Helicobacter pylori infection by triple therapy with pantoprazole, amoxicillin, and metronidazole
    Barbara Gawronska-Szklarz
    Department of Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, 70 111, Szczecin, Poland
    Eur J Clin Pharmacol 66:681-7. 2010

Research Grants

  1. MDR Gene Polymorphisms in AML
    Maria Baer; Fiscal Year: 2007
  2. REGULATION OF MULTIDRUG RESISTANCE PHENOTYPE
    William Hait; Fiscal Year: 2002
  3. DEVELOPMENT OF NEW SEMISYNTHETIC TAXANES
    Ralph Bernacki; Fiscal Year: 2001
  4. GENETIC ANALYSIS OF PLEIOTROPIC DRUG RESISTANCE
    W Moye Rowley; Fiscal Year: 1993
  5. MODULATION OF MULTIDRUG RESISTANCE MECHANISMS
    Branimir Sikic; Fiscal Year: 2002
  6. MDR1 GENE THERAPY IN CD34+ CELLS AND SCID MICE
    James Doroshow; Fiscal Year: 2002
  7. Vaginal Drug Delivery of P-glycoprotein Substrates
    Giovanni Pauletti; Fiscal Year: 2003
  8. ABCB5 P-Glycoprotein in Cancer Multidrug Resistance
    Markus Frank; Fiscal Year: 2007
  9. ABCB5 P-Glycoprotein in Cancer Multidrug Resistance
    Markus H Frank; Fiscal Year: 2010
  10. XENOBIOTIC REGULATION OF LIVER P-GLYCOPROTEIN
    John Schuetz; Fiscal Year: 2001

Detail Information

Publications275 found, 100 shown here

  1. ncbi A "silent" polymorphism in the MDR1 gene changes substrate specificity
    Chava Kimchi-Sarfaty
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA
    Science 315:525-8. 2007
    ..We report that a synonymous SNP in the Multidrug Resistance 1 (MDR1) gene, part of a haplotype previously linked to altered function of the MDR1 gene product P-glycoprotein (P-gp), ..
  2. pmc Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo
    S Hoffmeyer
    Epidauros Biotechnology, Pharmacogenetics Laboratory, Am Neuland 1, D 82347 Bernried, Germany
    Proc Natl Acad Sci U S A 97:3473-8. 2000
    ..Homozygosity for this variant was observed in 24% of our sample population (n = 188). This polymorphism is expected to affect the absorption and tissue concentrations of numerous other substrates of MDR-1...
  3. pmc Let-7 modulates acquired resistance of ovarian cancer to Taxanes via IMP-1-mediated stabilization of multidrug resistance 1
    Benjamin Boyerinas
    Feinberg School of Medicine, Division Hematology Oncology, Northwestern University, Chicago, IL 60611, USA
    Int J Cancer 130:1787-97. 2012
    ..One of the resistance factors that protects cancer cells from Taxol-based therapy is multidrug resistance 1 (MDR1). micro(mi)RNAs are small noncoding RNAs that negatively regulate protein expression...
  4. ncbi Association of ABCB1/MDR1 and OPRM1 gene polymorphisms with morphine pain relief
    D Campa
    Department of Biology, University of Pisa, Pisa, Italy
    Clin Pharmacol Ther 83:559-66. 2008
    ..We focused on two such genes: ABCB1/MDR1, a major determinant of morphine bioavailability, and OPRM1, which encodes for the mu-opioid receptor, the ..
  5. ncbi Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study
    Jacques Fellay
    Division of Infectious Diseases, University Hospital of Lausanne, Lausanne, Switzerland
    Lancet 359:30-6. 2002
    ..This variability could have a genetic basis. We did a pharmacogenetics study to analyse the association between response to antiretroviral treatment and allelic variants of several genes...
  6. pmc Polymorphisms in the xenobiotic transporter Multidrug Resistance 1 (MDR1) and interaction with meat intake in relation to risk of colorectal cancer in a Danish prospective case-cohort study
    Vibeke Andersen
    Medical Department, Viborg Regional Hospital, DK 8800 Viborg, Denmark
    BMC Cancer 9:407. 2009
    The xenobiotic transporters, Multidrug Resistance 1 (MDR1/ABCB1) and Breast Cancer Resistance Protein (BCRP/ABCG2) may restrict intestinal absorption of various carcinogens, including heterocyclic amines (HCA) and polycyclic aromatic ..
  7. ncbi Isolation and expression of a complementary DNA that confers multidrug resistance
    P Gros
    Nature 323:728-31. 1986
    ..resistance are frequently associated with amplification and overexpression of a small group of genes termed mdr or gp170. Direct evaluation of the role of these genes in multidrug resistance has awaited the isolation of a member of ..
  8. ncbi ABCB1 genetic variability and methadone dosage requirements in opioid-dependent individuals
    Janet K Coller
    Discipline of Pharmacology, School of Medical Sciences, The University of Adelaide, and Department of Clinical Pharmacology, Royal Adelaide Hospital, SA, Australia
    Clin Pharmacol Ther 80:682-90. 2006
    ..Methadone is a substrate for the P-glycoprotein transporter, encoded by the ABCB1 gene, which regulates central nervous system exposure...
  9. pmc Comprehensive pharmacogenetic analysis of irinotecan neutropenia and pharmacokinetics
    Federico Innocenti
    The University of Chicago, Chicago, IL 60637, USA
    J Clin Oncol 27:2604-14. 2009
    ..We aim to identify genetic variation, in addition to the UGT1A1*28 polymorphism, that can explain the variability in irinotecan (CPT-11) pharmacokinetics and neutropenia in cancer patients...
  10. doi Effects of CYP2C19, MDR1, and interleukin 1-B gene variants on the eradication rate of Helicobacter pylori infection by triple therapy with pantoprazole, amoxicillin, and metronidazole
    Barbara Gawronska-Szklarz
    Department of Pharmacology, Pomeranian Medical University, Powstancow Wlkp 72, 70 111, Szczecin, Poland
    Eur J Clin Pharmacol 66:681-7. 2010
    ..Aim of the present study was to evaluate an association of CYP2C19, MDR1, and IL-1B polymorphisms with the eradication rate of H...
  11. ncbi Influence of polymorphisms of ABCB1 and ABCC2 on mRNA and protein expression in normal and cancerous kidney cortex
    S Haenisch
    Institute of Pharmacology, University Hospital Schleswig Holstein, Kiel, Germany
    Pharmacogenomics J 7:56-65. 2007
    There is increasing evidence that polymorphisms of the adenosine 5' triphosphate membrane transporters ABCB1 (P-glycoprotein, MDR1) may affect expression and function, whereas less information is available about the impact of ABCC2 (..
  12. doi Polymorphisms in the drug transporter gene ABCB1 predict antidepressant treatment response in depression
    Manfred Uhr
    Max Planck Institute of Psychiatry, Kraepelinstr 10, 80804 Munich, Germany
    Neuron 57:203-9. 2008
    ..system depends on its ability to pass the blood-brain barrier, which is regulated by transporter molecules such as ABCB1 (MDR1)...
  13. pmc Human AP endonuclease (APE1/Ref-1) and its acetylation regulate YB-1-p300 recruitment and RNA polymerase II loading in the drug-induced activation of multidrug resistance gene MDR1
    S Sengupta
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555 1079, USA
    Oncogene 30:482-93. 2011
    ..with Y-box-binding protein 1 (YB-1), and acts as its coactivator for the expression of multidrug resistance gene MDR1, thereby causing drug resistance...
  14. ncbi Modulation of multidrug resistance P-glycoprotein 1 (ABCB1) expression in human heart by hereditary polymorphisms
    Konrad Meissner
    Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University Greifswald, Germany
    Pharmacogenetics 14:381-5. 2004
    Variable expression of the ABC-type multidrug resistance membrane protein P-glycoprotein (P-gp, MDR1, ABCB1) in human heart is a potential modulator of drug effects or drug-induced cardiotoxicity...
  15. doi A MDR1 (ABCB1) gene single nucleotide polymorphism predicts outcome of temozolomide treatment in glioblastoma patients
    M Schaich
    Department of Medicine I, University Hospital C G Carus, Dresden, Germany
    Ann Oncol 20:175-81. 2009
    ..We aimed to confirm first that temozolomide is a target for the multidrug resistance transporter MDR1/ABCB1 and second to investigate whether genetic variants of the MDR1 gene are associated with the survival of ..
  16. ncbi A common P-glycoprotein polymorphism is associated with nortriptyline-induced postural hypotension in patients treated for major depression
    R L Roberts
    Department of Pathology, Christchurch School of Medicine, Christchurch, New Zealand
    Pharmacogenomics J 2:191-6. 2002
    The multi-drug resistance gene ABCB1 (or MDR1) encodes a P-glycoprotein (P-gp) that regulates passage of many substances across the blood-brain barrier...
  17. ncbi ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment
    Severine Crettol
    Unite de Biochimie et Psychopharmacologie Clinique, Centre de Neurosciences Psychiatriques, Département de Psychiatrie Centre Hospitalier Universitaire Vaudois, Hôpital de Cery, Prilly Lausanne, Switzerland
    Clin Pharmacol Ther 80:668-81. 2006
    ..The in vivo implication of various cytochrome P450 (CYP) isoforms and of P-glycoprotein on methadone kinetics is unclear. We aimed to thoroughly examine the genetic factors influencing methadone kinetics and response to treatment...
  18. ncbi Imatinib disposition and ABCB1 (MDR1, P-glycoprotein) genotype
    H Gurney
    Department of Medical Oncology, Westmead Hospital Sydney West Area Health Service, Westmead, New South Wales, Australia
    Clin Pharmacol Ther 82:33-40. 2007
    ..1 and at steady-state were compared with elimination phenotype and single-nucleotide polymorphisms of CYP3A5 and ABCB1. A fivefold variation in estimated imatinib clearance (CL/F) was present on day 1 and mean CL/F had fallen by 26% ..
  19. ncbi P-glycoprotein models of the apo and ATP-bound states based on homology with Sav1866 and MalK
    Megan L O'Mara
    Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta, Canada
    FEBS Lett 581:4217-22. 2007
    ..These conformations (see supplementary material) may characterize some of the major steps in the nucleotide catalytic cycle...
  20. ncbi Identification of functionally variant MDR1 alleles among European Americans and African Americans
    R B Kim
    Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, USA
    Clin Pharmacol Ther 70:189-99. 2001
    b>MDR1 (P-glycoprotein) is an important factor in the disposition of many drugs, and the involved processes often exhibit considerable interindividual variability that may be genetically determined...
  21. pmc ABCB1 (MDR1) genetic variants are associated with methadone doses required for effective treatment of heroin dependence
    Orna Levran
    Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065, USA
    Hum Mol Genet 17:2219-27. 2008
    ..Methadone is a substrate of the transporter P-glycoprotein (P-gp) 170 that is encoded by the ABCB1 (MDR1) gene. Thus, P-gp variants may play a role in methadone absorption and distribution...
  22. pmc Processing mutations disrupt interactions between the nucleotide binding and transmembrane domains of P-glycoprotein and the cystic fibrosis transmembrane conductance regulator (CFTR)
    Tip W Loo
    Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 283:28190-7. 2008
    P-glycoprotein (P-gp, ABCB1) is an ATP-dependent drug pump. Each of its two homologous halves contains a transmembrane domain (TMD) that has six transmembrane (TM) segments and a nucleotide-binding domain (NBD)...
  23. ncbi Environmental and genetic factors associated with morphine response in the postoperative period
    Laurent Coulbault
    Pharmacology Department, Saint Antoine University of Medicine, University Pierre et Marie Curie, Paris, France
    Clin Pharmacol Ther 79:316-24. 2006
    ..The aim of this study was to investigate the respective influence of genetic and nongenetic factors on morphine dose requirements and adverse effects after colorectal surgery...
  24. doi Multidrug resistance gene (MDR1) polymorphisms correlate with imatinib response in chronic myeloid leukemia
    Ling Na Ni
    Department of Hematology, Jiangsu Province Hospital, The First Affiliated Nanjing Medical University Hospital, Nanjing Medical University, 300 Guangzhou Rd, 210029 Nanjing, China
    Med Oncol 28:265-9. 2011
    The human multidrug resistance gene (MDR1, ABCB1) codes for P-glycoprotein (P-gp) that affects the pharmacokinetics of many drugs. MDR1 single nucleotide polymorphisms (SNPs) are associated with drug clearance...
  25. doi Multidrug resistance gene (MDR1) polymorphisms are associated with major molecular responses to standard-dose imatinib in chronic myeloid leukemia
    Stéphanie Dulucq
    Laboratoire Hématopoïèse Leucémique et Cible Thérapeutique, Universite Victor Segalen Bordeaux 2, Inserm U876, Bordeaux, France
    Blood 112:2024-7. 2008
    ..Imatinib has been reported to be a substrate of the P-glycoprotein pump. In the current study, we focused on the ABCB1 (MDR1) genotype...
  26. ncbi Consequences of genetic polymorphisms for sirolimus requirements after renal transplant in patients on primary sirolimus therapy
    Dany Anglicheau
    Unité INSERM UMR S490, Molecular Toxicology, Centre Universitaire des Saints Peres, Universite Rene Descartes, Paris, France
    Am J Transplant 5:595-603. 2005
    Sirolimus (SRL) is a substrate for cytochromes P-450 3A and P-glycoprotein, the product of the MDR1 gene...
  27. pmc Regulatory role of human AP-endonuclease (APE1/Ref-1) in YB-1-mediated activation of the multidrug resistance gene MDR1
    Ranajoy Chattopadhyay
    Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas 77555 1079, USA
    Mol Cell Biol 28:7066-80. 2008
    ..1 (YB-1) and enhances its binding to the Y-box element, leading to the activation of the multidrug resistance gene MDR1. The enhanced MDR1 level due to the ectopic expression of wild-type APE1 but not of its nonacetylable mutant ..
  28. ncbi Pharmacogenomics of MDR1/ABCB1 gene: the influence on risk and clinical outcome of haematological malignancies
    Krzysztof Jamroziak
    Department of Haematology, Medical University of Lodz, Poland
    Hematology 9:91-105. 2004
    ..The multi-drug resistance-1, MDR1 (ABCB1) gene belongs to ATP-binding cassette (ABC) family and encodes for membrane transporter P-glycoprotein (P-gp)...
  29. ncbi Monocyte chemoattractant protein-1 (MCP-1) gene polymorphism and risk of Alzheimer's disease in Italians
    Roberto Pola
    Laboratory of Vascular Biology and Genetics, Department of Medicine, A Gemelli University Hospital, Università Cattolica del Sacro Cuore School of Medicine, Rome, Italy
    Exp Gerontol 39:1249-52. 2004
    ....
  30. ncbi Genetic polymorphisms in the ABCB1 gene and the effects of fentanyl in Koreans
    H J Park
    Department of Anesthesiology, Inha University Hospital, Inha University, Incheon, South Korea
    Clin Pharmacol Ther 81:539-46. 2007
    P-glycoprotein (PGP) is a polymorphic transporter encoded by the ABCB1 gene that contributes to the access of xenobiotics into the brain...
  31. ncbi P-glycoprotein: from genomics to mechanism
    Suresh V Ambudkar
    Laboratory of Cell Biology, Center for Cancer Research, National Cancer Institute NIH, 37 Convent Drive, Building 37, Room 1A 09, Bethesda, MD 20892 4254, USA
    Oncogene 22:7468-85. 2003
    ..The first of these to be identified was P-glycoprotein (P-gp), the product of the human MDR1 gene, localized to chromosome 7q21. P-gp is a member of the large ATP-binding cassette (ABC) family of proteins...
  32. doi Association of the colorectal cancer and MDR1 gene polymorphism in an Iranian population
    Azam Khedri
    Islamic Azad University Branch Masjedsoleiman, Masjedsoleiman, Iran
    Mol Biol Rep 38:2939-43. 2011
    The human multidrug resistance (MDR1) gene product P-glycoprotein is highly expressed in intestinal epithelial cells, where it constitutes a barrier against xenobiotics, bacterial toxins, drugs and other biologically active compounds, ..
  33. ncbi Variable expression of P-glycoprotein in the human placenta and its association with mutations of the multidrug resistance 1 gene (MDR1, ABCB1)
    Monika Hitzl
    Dr Margarete Fischer Bosch Institute of Clinical Pharmacology, Stuttgart, Germany
    Pharmacogenetics 14:309-18. 2004
    The MDR1 gene product P-glycoprotein in the human placenta is important for protecting the fetus from unintended, harmful drug exposure, but also for limiting the access of therapeutic drugs to the fetus after maternal drug intake...
  34. ncbi Digoxin pharmacokinetics and MDR1 genetic polymorphisms
    Celine Verstuyft
    Department of Pharmacology, Saint Antoine Hospital, 184 rue du Faubourg Saint Antoine, 75012, Paris, France
    Eur J Clin Pharmacol 58:809-12. 2003
    The effect of MDR1 C3435T single nucleotide polymorphism (SNP) in exon 26 on digoxin pharmacokinetics has recently been challenged. OBJECTIVE...
  35. ncbi The association of common SNPs and haplotypes in the CETP and MDR1 genes with lipids response to fluvastatin in familial hypercholesterolemia
    Dani Bercovich
    The Laboratory for Molecular Genetics and Pharmacogenetics, Migal Galilee Technology Center, Kiryat Shmona, Israel
    Atherosclerosis 185:97-107. 2006
    To examine whether genetic polymorphisms in the cholesteryl-ester transfer protein (CETP) and the P-glycoprotein drug transporter (MDR1), are associated with variable lipid response to fluvastatin.
  36. doi Impact of genetic variants on post-clopidogrel platelet reactivity in patients after elective percutaneous coronary intervention
    Orsolya Rideg
    Institute of Laboratory Medicine, University of Pecs, 13 Ifjúság Street, H 7624 Pecs, Hungary
    Pharmacogenomics 12:1269-80. 2011
    ..To determine the effect of various SNPs on post-clopidogrel platelet reactivity and clinical outcome...
  37. ncbi Promoter polymorphisms and allelic imbalance in ABCB1 expression
    Corinne Loeuillet
    Institute of Microbiology, University Hospital, Lausanne, Switzerland
    Pharmacogenet Genomics 17:951-9. 2007
    The ABCB1 (MDR1) gene, encoding the transporter P-glycoprotein, is known to act on a broad range of prescription medicines. For this reason a large number of studies have assessed the functional consequences of variation in this gene...
  38. doi Human P-glycoprotein is active when the two halves are clamped together in the closed conformation
    Tip W Loo
    Department of Medicine, University of Toronto, Toronto, Ontario, Canada
    Biochem Biophys Res Commun 395:436-40. 2010
    The P-glycoprotein (P-gp, ABCB1) drug pump protects us from toxic compounds and confers multidrug resistance...
  39. doi CYP3A5 and ABCB1 polymorphisms influence tacrolimus concentrations in peripheral blood mononuclear cells after renal transplantation
    Arnaud Capron
    Department of Clinical Chemistry, Cliniques Universitaires St Luc, Universite Catholique de Louvain, Brussels, Belgium
    Pharmacogenomics 11:703-14. 2010
    ..investigated the effect of genetic polymorphisms in a biotransformation enzyme (CYP3A5) and a transporter protein (ABCB1) on tacrolimus (Tac) whole blood concentrations in renal transplantation, and more specifically on peripheral ..
  40. doi Pim-1 kinase protects P-glycoprotein from degradation and enables its glycosylation and cell surface expression
    Yingqiu Xie
    University of Maryland Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Mol Pharmacol 78:310-8. 2010
    ..The ABC transporter P-glycoprotein (Pgp; ABCB1) also contains a Pim-1 phosphorylation consensus sequence, and we hypothesized that Pim-1 also regulates Pgp...
  41. doi Variation of MDR proteins expression and activity levels according to clinical status and evolution of CML patients
    Flavia C Vasconcelos
    Laboratório de Hemato Oncologia Celular e Molecular, Programa de Pesquisa em Hemato Oncologia Molecular, Instituto Nacional de Cancer INCA, Rio de Janeiro, Brazil
    Cytometry B Clin Cytom 80:158-66. 2011
    ..expression at protein and mRNA levels, whereas in the Pgp negative cell line, this drug was capable of decreasing MDR1/Pgp mRNA levels...
  42. ncbi Multi-drug resistance gene-1 (MDR-1) haplotypes and the CYP3A5*1 genotype have no influence on ciclosporin dose requirements as assessed by C0 or C2 measurements
    Salim Fredericks
    Analytical Unit, Cardiac and Vascular Science, St George s University of London, London, UK
    Clin Transplant 21:252-7. 2007
    ..MDR-1 SNPs and haplotypes and also CYP3A5*1 genotype, do not appear to have a major influence on ciclosporin pharmacokinetics...
  43. doi Protective effect of the CYP2C19 *17 polymorphism with increased activation of clopidogrel on cardiovascular events
    Klaus A Tiroch
    Deutsches Herzzentrum Munchen, Rechts der Isar, Technische Universitat, Germany
    Am Heart J 160:506-12. 2010
    ..Reduced-function alleles have been associated with an increase in cardiovascular events...
  44. doi ABCB1 gene polymorphisms are associated with the severity of major depressive disorder and its response to escitalopram treatment
    Keh Ming Lin
    Division of Mental Health and Addiction Medicine, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Miaoli County, Taiwan
    Pharmacogenet Genomics 21:163-70. 2011
    ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1) is a drug transporter protein expressed on the epithelial cells of the intestine and the endothelial cells of the blood-brain barrier...
  45. doi Correlation between genetic polymorphisms of the hOCT1 and MDR1 genes and the response to imatinib in patients newly diagnosed with chronic-phase chronic myeloid leukemia
    Margherita Maffioli
    Hematology Department, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Leuk Res 35:1014-9. 2011
    The association between seven polymorphisms in the genes hOCT1 and MDR1, encoding for imatinib transporter proteins, and the response to imatinib 400mg/daily was investigated in 65 patients newly diagnosed with chronic-phase chronic ..
  46. ncbi Regulatory polymorphisms of multidrug resistance 1 (MDR1) gene are associated with the development of childhood acute lymphoblastic leukemia
    Hiroyoshi Hattori
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Leuk Res 31:1633-40. 2007
    The aim of this study is to determine whether the polymorphisms of the MDR1 gene are associated with the development of childhood acute lymphoblastic leukemia (ALL)...
  47. doi Association of MDR1 and ERCC1 polymorphisms with response and toxicity to cisplatin-based chemotherapy in non-small-cell lung cancer patients
    Songjian Chen
    Analytical Cytology Laboratory, Shantou University Medical College, Shantou, Guangdong, PR China
    Int J Hyg Environ Health 213:140-5. 2010
    ..In this study, we have investigated whether polymorphisms in genes that control import/export of drugs (MDR1) and that repair DNA adducts (ERCC1) are involved with drug resistance in non-small cell lung cancer (NSCLC) ..
  48. ncbi ABCB1 modulation does not circumvent drug extrusion from primitive leukemic progenitor cells and may preferentially target residual normal cells in acute myelogenous leukemia
    Marc H G P Raaijmakers
    Department of Hematology and Central Hematology Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Clin Cancer Res 12:3452-8. 2006
    ..Modulation of the multidrug ATP-binding cassette transporter ABCB1 has not resulted in improved outcome in AML, raising the question whether leukemic CD34+ CD38- cells are targeted ..
  49. ncbi No association between MDR1 (ABCB1) 2677G>T and 3435C>T polymorphism and sporadic colorectal cancer among Bulgarian patients
    Darinka Todorova Petrova
    Department of Medical Genetics, Medical University Sofia, 2, Zdrave Str, 1431 Sofia, Bulgaria
    J Cancer Res Clin Oncol 134:317-22. 2008
    ..Thus, polymorphisms that reduce the activity of the MDR1 (ABCB1) efflux pump are potential risk factors for colorectal carcinogenesis...
  50. ncbi Caveolin-1 gene is coordinately regulated with the multidrug resistance 1 gene in normal and leukemic bone marrow
    Annie Pang
    University Department of Medicine, Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, PR China
    Leuk Res 28:973-7. 2004
    ..The coordinate expression of caveolin-1 and MDR-1 suggests that they may either interact physically, or are involved in the same aberrant pathway(s) activated during MDR-1 up-regulation...
  51. doi Structural insights into P-glycoprotein (ABCB1) by small angle X-ray scattering and electron crystallography
    Christopher A McDevitt
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, John Radcliffe Hospital, Oxford, UK
    FEBS Lett 582:2950-6. 2008
    P-glycoprotein (ABCB1) is an ATP-binding cassette protein that is associated with the acquisition of multi-drug resistance in cancer and the failure of chemotherapy in humans...
  52. doi Influence of CYP3A5 genetic polymorphism on tacrolimus daily dose requirements and acute rejection in renal graft recipients
    Lina Quteineh
    Pharmacology Department, Pierre et Marie Curie University, Saint Antoine University Hospital, Paris, France
    Basic Clin Pharmacol Toxicol 103:546-52. 2008
    ..Our objective was to determine the influence of CYP3A5 and ABCB1 genetic polymorphisms on tacrolimus daily requirements and on transplantation outcome...
  53. doi Association of genetic polymorphisms in ESR2, HSD17B1, ABCB1, and SHBG genes with colorectal cancer risk
    J Sainz
    Division of Molecular Genetic Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
    Endocr Relat Cancer 18:265-76. 2011
    ..COMT, HSD17B1, CYP1A1, CYP17A1, CYP1A2, CYP1B1, CYP2C9, CYP3A4, CYP2C19, and GSTP1), and hormone transporter (ABCB1) genes with the risk of CRC in German women and men, separately...
  54. doi MDR1 haplotypes conferring an increased expression of intestinal CYP3A4 rather than MDR1 in female living-donor liver transplant patients
    Keiko Hosohata
    Department of Pharmacy, Kyoto University Hospital, Shogoin, Sakyo ku, Kyoto 606 8507, Japan
    Pharm Res 26:1590-5. 2009
    This study investigated whether haplotypes in the multidrug resistance 1 (MDR1) gene had effects on mRNA expression levels of MDR1 and cytochrome P450 (CYP) 3A4, and on the pharmacokinetics of tacrolimus in living-donor liver transplant (..
  55. ncbi Location of the rhodamine-binding site in the human multidrug resistance P-glycoprotein
    Tip W Loo
    Canadian Institutes of Health Research Group in Membrane Biology, Department of Medicine, University of Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 277:44332-8. 2002
    ..The results support the "substrate-induced fit" hypothesis for drug binding...
  56. ncbi CYP3A4 and MDR1 alleles in a Portuguese population
    Isa Cavaco
    Laboratory of Molecular Toxicology, CMQA, Faculty of Sciences and Technology, University of Algarve, Faro, Portugal
    Clin Chem Lab Med 41:1345-50. 2003
    ..In this study we have determined the frequencies of CYP3A4 and MDR1 alleles in Portuguese Caucasians...
  57. ncbi Polymorphisms of the MDR1 gene in the Czech population
    K Pechandová
    Clinical Pharmacology Unit, Department of Pharmacology, 1st Faculty of Medicine, Charles University, Prague, Czech Republic
    Folia Biol (Praha) 52:184-9. 2006
    ..Previously identified polymorphisms in the MDR1 gene belong to important factors causing this phenomenon...
  58. doi Haplotypic structure of ABCB1/MDR1 gene modifies the risk of the acute allograft rejection in renal transplant recipients
    Stepan Bandur
    Transplant Laboratory, Institute for Clinical and Experimental Medicine, Prague, Czech Republic
    Transplantation 86:1206-13. 2008
    ..Tac) and cyclosporine is determined by cytochrome P450IIIA and by P-glycoprotein encoded by the CYP3A4/CYP3A5 and ABCB1 genes...
  59. doi MDR1 single nucleotide polymorphism G2677T/A and haplotype are correlated with response to docetaxel-cisplatin chemotherapy in patients with non-small-cell lung cancer
    Ji Hong Pan
    Key Laboratory of the Ministry of Public Health for Biotech Drug, Key Laboratory for Modern Medicine and Technology of Shandong Province, Shandong Medicinal and Biotechnology Center, Shandong Academy of Medical Sciences, Jinan, China
    Respiration 78:49-55. 2009
    The multidrug resistance gene 1 (MDR1) encodes P-glycoprotein (P-gp), which plays an important role in mediating multidrug resistance to chemotherapeutic agents...
  60. ncbi Identification of polymorphisms on the MDR1 gene among Turkish population and their effects on multidrug resistance in acute leukemia patients
    Pelin Kaya
    Department of Biology, Middle East Technical University, Ankara, Turkey
    Am J Hematol 80:26-34. 2005
    ..This protein is the product of the MDR1 gene...
  61. doi Tight junction regulation by morphine and HIV-1 tat modulates blood-brain barrier permeability
    Supriya D Mahajan
    Division of Allergy, Immunology, and Rheumatology, Department of Medicine, Buffalo General Hospital, 301 Multi Research Bldg, 100 High Street, Buffalo, NY 14203, USA
    J Clin Immunol 28:528-41. 2008
    ..These studies may lead to the development of novel anti-HIV-1 therapeutics that target specific TJ proteins, thus preventing TJ disruption in opiate using HIV-1 patients...
  62. ncbi Tacrolimus dosing in Chinese renal transplant patients is related to MDR1 gene C3435T polymorphisms
    D Li
    Organ Transplantation, The Third Xiangya Hospital, Changsha, Hunan, China
    Transplant Proc 38:2850-2. 2006
    ..The polymorphism C3435T of MDR1, the gene coding P-gp, may influence the expression and activity of P-gp...
  63. doi Influence of host genetic factors on efavirenz plasma and intracellular pharmacokinetics in HIV-1-infected patients
    Laure Elens
    Louvain Centre for Toxicology and applied Pharmacology, Universite Catholique de Louvain, 53 02, avenue E Mounier, 1200 Bruxelles, Belgium
    Pharmacogenomics 11:1223-34. 2010
    ..Previous studies have identified some possible genetic determinants of the variability in plasma concentrations. However, their impact on EFV intracellular pharmacokinetics remains mostly unexplored...
  64. doi Errors and reproducibility of DNA array-based detection of allelic variants in ADME genes: PHARMAchip
    Elisabet Cuyàs
    Human Pharmacology and Clinical Neurosciences Research Group of the Neuropsychopharmacology Program, Institut Municipal d Investigació Mèdica IMIM Hospital del Mar, Parc de Recerca Biomedica de Barcelona, c Dr Aiguader 88 08003 Barcelona, Spain
    Pharmacogenomics 11:257-66. 2010
    ..The aim of this study was to assess the suitability of PHARMAchip for the genotyping of polymorphisms of genes associated with drug metabolism and response as an alternative to Jurilab Ltd's DrugMEt Test...
  65. pmc P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model
    John R Cirrito
    Department of Neurology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Clin Invest 115:3285-90. 2005
    ..These data establish a direct link between Pgp and Abeta metabolism in vivo and suggest that Pgp activity at the BBB could affect risk for developing AD as well as provide a novel diagnostic and therapeutic target...
  66. ncbi UGT1A1 polymorphism can predict hematologic toxicity in patients treated with irinotecan
    Jean Francois Cote
    Institut National de la Sante et de la Recherche Medicale UMR S775, Bases Moléculaires de la Réponse aux Xénobiotiques, Universite Paris Descartes, Assistance Publique Hopitaux de Paris, France
    Clin Cancer Res 13:3269-75. 2007
    ....
  67. ncbi Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
    Silke Vogelgesang
    Departments of Neuropathology and Pharmacology, Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, University of Greifswald, Greifswald, Germany
    Pharmacogenetics 12:535-41. 2002
    ..Our results provide the first evidence in human brain tissue that the accumulation of Abeta may be influenced by the expression of P-gp in blood vessels, and suggest that P-gp may influence the elimination of Abeta from brain...
  68. ncbi Modulation of function of three ABC drug transporters, P-glycoprotein (ABCB1), mitoxantrone resistance protein (ABCG2) and multidrug resistance protein 1 (ABCC1) by tetrahydrocurcumin, a major metabolite of curcumin
    Pornngarm Limtrakul
    Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
    Mol Cell Biochem 296:85-95. 2007
    ..proteins, P-glycoprotein (P-gp or ABCB1), mitoxantrone resistance protein (MXR or ABCG2) and multidrug resistance protein 1 (MRP1 or ABCC1) was investigated, to assess whether an ultimate metabolite form of curcuminoids (THC) ..
  69. ncbi Polymorphisms in multidrug resistance 1 (MDR1) gene are associated with refractory Crohn disease and ulcerative colitis
    U Potocnik
    Laboratory of Molecular Genetics, Institute of Pathology, Medical Faculty, Ljubljana, Slovenia
    Genes Immun 5:530-9. 2004
    We used coding and noncoding polymorphisms evenly spaced across the ABCB1/MDR1 gene to perform association analysis in Slovenian patients with inflammatory bowel diseases and to obtain haplotype structure and patterns of linkage ..
  70. ncbi Pharmacogenetics of efavirenz and central nervous system side effects: an Adult AIDS Clinical Trials Group study
    David W Haas
    Program for Human Genetics, Vanderbilt University School of Medicine, 345 24th Avenue North, Nashville, TN 37203, USA
    AIDS 18:2391-400. 2004
    ..Efavirenz is metabolized by cytochrome P4502B6 (CYP2B6). We investigated whether polymorphisms in CYP2B6, CYP3A4, CYP3A5, and MDR1 were associated with efavirenz central nervous system side effects and pharmacokinetics.
  71. doi Influence of ABCB1 and ABCG2 polymorphisms on doxorubicin disposition in Asian breast cancer patients
    Suman Lal
    Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, National Cancer Center, 11 Hospital Drive, 169610 Singapore
    Cancer Sci 99:816-23. 2008
    The influence of three high frequency ABCB1 polymorphisms (c.1236C>T, c.2677G>A/T, and c.3435C>T) and the ABCG2 c...
  72. doi ABCB1 (MDR 1) polymorphisms and progression-free survival among women with ovarian cancer following paclitaxel/carboplatin chemotherapy
    Sharon E Johnatty
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Clin Cancer Res 14:5594-601. 2008
    The human ABCB1 gene encodes P-glycoprotein, which transports a broad range of anticancer drugs, including paclitaxel...
  73. ncbi Multidrug resistance: molecular mechanisms and clinical relevance
    V Ling
    BC Cancer Research Centre, Vancouver, Canada
    Cancer Chemother Pharmacol 40:S3-8. 1997
    ..Although the physiological role of MRP is not yet understood, one Pgp gene (mdr1) plays an important role in the blood-tissue barrier and the other (mdr2/3) is involved in phospholipid transport ..
  74. doi Clinical relevance of a pharmacogenetic approach using multiple candidate genes to predict response and resistance to imatinib therapy in chronic myeloid leukemia
    Dong Hwan Dennis Kim
    Chronic Myelogenous Leukemia Group, Department of Hematology Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 135 710, Korea
    Clin Cancer Res 15:4750-8. 2009
    ..Several cellular and genetic mechanisms of imatinib resistance have been proposed, including amplification and overexpression of the BCR/ABL gene, the tyrosine kinase domain point mutations, and MDR1 gene overexpression.
  75. ncbi MDR1 genotype-related pharmacokinetics of digoxin after single oral administration in healthy Japanese subjects
    T Sakaeda
    Department of Hospital Pharmacy, School of Medicine, Kobe University, Japan
    Pharm Res 18:1400-4. 2001
    To evaluate the MDR1 genotype frequency in the Japanese population and to study the relationship between the MDR1 genotype and the pharmacokinetics of digoxin after single oral administration in healthy subjects.
  76. pmc Glucosylceramide synthase upregulates MDR1 expression in the regulation of cancer drug resistance through cSrc and beta-catenin signaling
    Yong Yu Liu
    Department of Basic Pharmaceutical Sciences, University of Louisiana at Monroe, Monroe, Louisiana 71209, USA
    Mol Cancer 9:145. 2010
    Drug resistance is the outcome of multiple-gene interactions in cancer cells under stress of anticancer agents. MDR1 overexpression is most commonly detected in drug-resistant cancers and accompanied with other gene alterations including ..
  77. ncbi Simultaneous binding of two different drugs in the binding pocket of the human multidrug resistance P-glycoprotein
    Tip W Loo
    Canadian Institutes of Health Research Group in Membrane Biology, and Department of Medicine and, University of Toronto, Toronto, Ontario M5S 1A8, Canada
    J Biol Chem 278:39706-10. 2003
    The human multidrug resistance P-glycoprotein (P-gp, ABCB1) transports a wide variety of structurally diverse compounds out of the cell. The drug-binding pocket of P-gp is located in the transmembrane domains...
  78. ncbi Association of an ABCB1 gene haplotype with pharmacoresistance in temporal lobe epilepsy
    F Zimprich
    Department of Clinical Neurology, Medical University of Vienna, Austria
    Neurology 63:1087-9. 2004
    ..To assess the role of functional variations in its coding gene (ABCB1) the authors genotyped 210 patients with TLE who were stratified according to their degree of drug resistance...
  79. ncbi Irinotecan pathway genotype analysis to predict pharmacokinetics
    Ron H J Mathijssen
    Department of Medical Oncology, Erasmus MC Daniel den Hoed Cancer Center, 3075 EA Rotterdam, The Netherlands
    Clin Cancer Res 9:3246-53. 2003
    ..The purpose was to explore the relationships between irinotecan disposition and allelic variants of genes coding for adenosine triphosphate binding cassette transporters and enzymes of putative relevance for irinotecan...
  80. doi Association of a polymorphism of ABCB1 with obesity in Japanese individuals
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Genomics 91:512-6. 2008
    ..only the 2677G --> A/T polymorphism (rs2032582) of the ATP-binding cassette, subfamily B, member 1 gene (ABCB1) was significantly associated (p=0.0003) with obesity...
  81. doi MDR1 (C3435T) polymorphism: relation to the risk of breast cancer and therapeutic outcome
    M Cizmarikova
    Department of Pharmacology, Faculty of Medicine, P J Safarik University, Kosice, Slovak Republic
    Pharmacogenomics J 10:62-9. 2010
    P-glycoprotein (PGP), the product of the MDR1 gene, is a transmembrane active efflux pump for a variety of carcinogens and cytostatics...
  82. pmc ABCB1/MDR1 gene polymorphisms as a prognostic factor in colorectal cancer
    Ewa Balcerczak
    Department of Pharmaceutical Biochemistry, Medical University of Lodz, Lodz, Poland
    Int J Colorectal Dis 25:1167-76. 2010
    To analyse the single-nucleotide polymorphisms (SNPs): ABCB1(1236C>T), ABCB1(2677G>T/A), ABCB1(3435C>T) and haplotypes in the ABCB1/MDR1 gene, which could contribute to genetic risk of colorectal cancer (CRC)...
  83. ncbi ABCB1 gene polymorphisms and expression of P-glycoprotein and long-term prognosis in colorectal cancer
    Sara De Iudicibus
    Department of Life Sciences, University of Trieste, Italy
    Anticancer Res 28:3921-8. 2008
    P-glycoprotein (Pgp), encoded by the ATP-binding cassette B1 (ABCB1) gene, is an efflux transporter located on the luminal side of intestinal epithelial cells, which protects the gut from endogenous and exogenous toxins...
  84. doi PXR pharmacogenetics: association of haplotypes with hepatic CYP3A4 and ABCB1 messenger RNA expression and doxorubicin clearance in Asian breast cancer patients
    Edwin Sandanaraj
    Laboratory of Clinical Pharmacology, Division of Medical Sciences, Humphrey Oei Institute of Cancer Research, Singapore, Singapore
    Clin Cancer Res 14:7116-26. 2008
    ..and to investigate the association between PXR haplotypes and hepatic mRNA expression of PXR and its downstream target genes, CYP3A4 and ABCB1, as well as their influence on the clearance of doxorubicin in Asian breast cancer patients.
  85. pmc CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium
    Yuji Takakura
    Department of Surgery, Hiroshima University, Hiroshima, Japan
    Cancer Res 70:6767-78. 2010
    ..Microarray-based gene expression studies revealed that the Multidrug Resistance 1 (MDR1/P-glycoprotein/ABCB1) gene was activated by CDX2...
  86. pmc A synonymous polymorphism in a common MDR1 (ABCB1) haplotype shapes protein function
    King Leung Fung
    Laboratory of Cell Biology, Center of Cancer Research, National Cancer Institute, National Institutes of Health, 37 Convent Drive, Room 2108, Bethesda, MD 20892 4254, USA
    Biochim Biophys Acta 1794:860-71. 2009
    The MDR1 (ABCB1) gene encodes a membrane-bound transporter that actively effluxes a wide range of compounds from cells. The overexpression of MDR1 by multidrug-resistant cancer cells is a serious impediment to chemotherapy...
  87. doi Common ATP-binding cassette B1 variants are associated with increased digoxin serum concentration
    Albert Jan L H J Aarnoudse
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    Pharmacogenet Genomics 18:299-305. 2008
    Digoxin is a known substrate of ATP-binding cassette B1 (ABCB1/MDR1). The results of studies on the association between ABCB1 polymorphisms and digoxin kinetics, however, remain contradictory...
  88. pmc Association between Genetic Polymorphism of Multidrug Resistance 1 Gene and Sasang Constitutions
    Hyun Ju Kim
    Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, 344 2 Shinyong dong, Iksan, Jeonbuk, 570 749, Republic of Korea Tel
    Evid Based Complement Alternat Med 6:73-80. 2009
    Multidrug resistance 1 (MDR1) is a gene that expresses P-glycoprotein (P-gp), a drug transporter protein...
  89. ncbi Regulation of MDR1 expression and drug resistance by a positive feedback loop involving hyaluronan, phosphoinositide 3-kinase, and ErbB2
    Suniti Misra
    Department of Cell Biology and Anatomy, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 280:20310-5. 2005
    ..These Akt-independent effects are dominant over the effects of Akt on doxorubicin resistance in MCF-7/Adr cells...
  90. ncbi Functional C3435T polymorphism of MDR1 gene: an impact on genetic susceptibility and clinical outcome of childhood acute lymphoblastic leukemia
    Krzysztof Jamroziak
    Department of Haematology, Medical University of Lodz, ul Pabianicka 62, 93 513 Lodz, Poland
    Eur J Haematol 72:314-21. 2004
    ..Recently, the single-nucleotide polymorphism C3435T of MDR1 gene has been found to be associated with altered tissue expression and function of P-gp...
  91. ncbi Genetic polymorphism in MDR-1: a tool for examining allelic expression in normal cells, unselected and drug-selected cell lines, and human tumors
    L A Mickley
    Medicine Branch, Division of Clinical Sciences DCS, National Cancer Institute NCI, Bethesda, MD 20892, USA
    Blood 91:1749-56. 1998
    ..Acquired drug resistance in vitro and in patients is often associated with expression of a single MDR-1 allele, and this can be a marker of a hybrid MDR-1 gene...
  92. ncbi MDR1 single nucleotide polymorphisms predict response to vinorelbine-based chemotherapy in patients with non-small cell lung cancer
    Ji Hong Pan
    Key Laboratory, Ministry of Public Health, Biotech Drugs, Shandong Medicinal and Biotechnology Center, Shandong Academy of Medical Sciences, Jinan, China
    Respiration 75:380-5. 2008
    ..The polymorphisms of genes participate in metabolism and transport, and therefore may have an impact on the response to vinorelbine...
  93. ncbi The effect of MDR1 (ABCB1) polymorphism on the pharmacokinetic of tacrolimus in Turkish renal transplant recipients
    S H Akbas
    Central Laboratory, Akdeniz University, Faculty of Medicine, Antalya, Turkey
    Transplant Proc 38:1290-2. 2006
    ..TRL is a substrate for P-glycoprotein (P-gp), the product of the multidrug resistance-1 (MDR1)(ABCB1) gene. P-gp acts as a membrane efflux pump, which affects TRL absorption from the gut...
  94. ncbi Association of the multidrug resistance-1 gene single-nucleotide polymorphisms with the tacrolimus dose requirements in renal transplant recipients
    Dany Anglicheau
    Unité INSERM UMR S490, Molecular Toxicology, Centre Universitaire des Saints Peres, Universite Rene Descartes, 45 Rue des Saints Peres, 75006 Paris, France univ paris5 fr
    J Am Soc Nephrol 14:1889-96. 2003
    ..interindividual variations, is a substrate for P-glycoprotein (P-gp), the product of the multidrug resistance-1 (MDR1) gene...
  95. ncbi Haplotype analysis of ABCB1/MDR1 blocks in a Japanese population reveals genotype-dependent renal clearance of irinotecan
    Kimie Sai
    Project Team for Pharmacogenetics, Division of Xenobiotic Metabolism and Disposition, National Institute of Health Sciences, 1 18 1, Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Pharmacogenetics 13:741-57. 2003
    We performed comprehensive haplotyping of ABCB1/MDR1 gene blocks using 49 genetic polymorphisms, including seven novel ones, obtained from 145 Japanese subjects...
  96. ncbi Associations of ABCB1, ABCC2, and ABCG2 polymorphisms with irinotecan-pharmacokinetics and clinical outcome in patients with advanced non-small cell lung cancer
    Ji Youn Han
    Research Institute and Hospital, National Cancer Center, Goyang, Korea
    Cancer 110:138-47. 2007
    The authors investigated whether ABCB1, ABCC2, and ABCG2 genetic polymorphisms affect pharmacokinetics (PK) of irinotecan and treatment outcome of patients with advanced nonsmall cell lung cancer (NSCLC).
  97. ncbi MDR1 polymorphism influences the outcome of multiple myeloma patients
    Gabriele Buda
    Department of Oncology, Transplants and Advanced Technologies, Section of Hematology, Pisa University, Pisa, Italy
    Br J Haematol 137:454-6. 2007
    The multidrug resistance gene (MDR1) has been reported to be an additional prognostic factor in acute myeloid leukaemia patients...
  98. ncbi MDR1 pharmacogenetics: frequency of the C3435T mutation in exon 26 is significantly influenced by ethnicity
    M M Ameyaw
    University of Aberdeen, Department of Medicine and Therapeutics, Institute of Medical Sciences, Foresterhill, Aberdeen, UK
    Pharmacogenetics 11:217-21. 2001
    P-glycoprotein (PGP), the product of the multidrug resistance gene (MDR1), acts as an energy-dependent efflux pump that exports its substrates out of the cell...
  99. doi Polymorphisms of ERCC1 C118T/C8092A and MDR1 C3435T predict outcome of platinum-based chemotherapies in advanced non-small cell lung cancer: a meta-analysis
    Hai Bo Wei
    Department of Oncology Medicine, The 3 rd Affiliated Hospital, Harbin Medical University, China
    Arch Med Res 42:412-20. 2011
    ..We performed this meta-analysis to compare outcome to platinum-based chemotherapies in advanced non-small cell lung cancer (NSCLC) with different ERCC1 C118T/C8092A and MDR1 C3435T polymorphisms.
  100. pmc MDR1 genotypes do not influence the absorption of a single oral dose of 1 mg digoxin in healthy white males
    Thomas Gerloff
    Institute of Clinical Pharmacology, Charite University Medical Center, Humboldt University, Berlin, Germany
    Br J Clin Pharmacol 54:610-6. 2002
    A noncoding single nucleotide polymorphism (SNP) in exon 26 3435C > T of the highly polymorphic MDR1 gene has been demonstrated to alter digoxin absorption after induction of the MDR1 gene product P-glycoprotein by rifampicin or after ..
  101. doi P-glycoprotein substrate transport assessed by comparing cellular and vesicular ATPase activity
    Pierluigi Nervi
    Biophysical Chemistry, Biozentrum, University of Basel, Klingelbergstrasse 70, Switzerland
    Biochim Biophys Acta 1798:515-25. 2010
    We compared the P-glycoprotein ATPase activity in inside-out plasma membrane vesicles and living NIH-MDR1-G185 cells with the aim to detect substrate transport...

Research Grants67

  1. MDR Gene Polymorphisms in AML
    Maria Baer; Fiscal Year: 2007
    The ATP-binding cassette (ABC) proteins P-glycoprotein (Pgp; MDR1; encoded by ABCB1), multidrug resistance-associated protein (MRP-1; encoded by ABCC1) and breast cancer resistance protein (BCRP; encoded by ABCG2) are energy-dependent ..
  2. REGULATION OF MULTIDRUG RESISTANCE PHENOTYPE
    William Hait; Fiscal Year: 2002
    ..One of the most exciting advances was the discovery of P-glycoprotein (P-gp), the MDR1 gene product, which can impart multi-drug resistance (MDR) by virtue of its ability to transport certain molecules ..
  3. DEVELOPMENT OF NEW SEMISYNTHETIC TAXANES
    Ralph Bernacki; Fiscal Year: 2001
    ..Clearly, second generation taxanes that have improved therapeutic activity against multi-drug resistant (MDR1 gene mediated) tumors would be advantageous...
  4. GENETIC ANALYSIS OF PLEIOTROPIC DRUG RESISTANCE
    W Moye Rowley; Fiscal Year: 1993
    ..Animal cells often acquire this property by amplifying the expression of a P-glycoprotein-encoding gene, MDR1. Yeast cells also possess a phenotype, known as pleiotropic drug resistance (Pdr), analogous to mammalian Mdr...
  5. MODULATION OF MULTIDRUG RESISTANCE MECHANISMS
    Branimir Sikic; Fiscal Year: 2002
    ..Studies of new modulators of MDR1/P-glycoprotein (P-gp) multidrug resistance (MDR) will continue...
  6. MDR1 GENE THERAPY IN CD34+ CELLS AND SCID MICE
    James Doroshow; Fiscal Year: 2002
    The human MDR1 gene encodes a multispecific drug transporter, P- glycoprotein (Pgp), that prevents drug accumulation in resistant cells. Overexpression of MDR1 is sufficient for conferring multidrug resistance on otherwise normal cells...
  7. Vaginal Drug Delivery of P-glycoprotein Substrates
    Giovanni Pauletti; Fiscal Year: 2003
    ..The MDR1 gene product P-gp is a prototype of membrane efflux systems that limit transcellular transport of drug molecules ..
  8. ABCB5 P-Glycoprotein in Cancer Multidrug Resistance
    Markus Frank; Fiscal Year: 2007
    Multidrug resistance (MDR) mediated by MDR1 (ABCB1) P-glycoprotein and related ATP-binding cassette (ABC) transporters is an impediment to successful cancer therapy...
  9. ABCB5 P-Glycoprotein in Cancer Multidrug Resistance
    Markus H Frank; Fiscal Year: 2010
    Multidrug resistance (MDR) mediated by MDR1 (ABCB1) P-glycoprotein and related ATP-binding cassette (ABC) transporters is an impediment to successful cancer therapy...
  10. XENOBIOTIC REGULATION OF LIVER P-GLYCOPROTEIN
    John Schuetz; Fiscal Year: 2001
    In our previous funding period we established that expression of the hepatic multidrug resistance (MDR1) gene product, P-glycoprotein, varies over 50-fold among individuals...
  11. P-Glycoprotein and Disposition of Psychostimulants
    JOHN MARKOWITZ; Fiscal Year: 2005
    ..The most prominent gene of the ABC cassette family of transporters, ABCB1 (also known as MDR1), is highly polymorphic and encodes for P-glycoprotein (PGP)...
  12. Role of the ABC Transporter ABCB6 in Cytotoxicity
    John Schuetz; Fiscal Year: 2006
    ..Our studies have sought to understand the function and regulation of ABC transporters with a focus on the MDR1 gene that encodes a protein conferring resistance to a large number of therapeutic drugs and cytotoxic compounds...
  13. IMAGING MULTIDRUG RESISTANCE AND MODULATION IN BREAST CA
    David Piwnica Worms; Fiscal Year: 2002
    ..Emergence of multidrug resistance (MDR) in breast cancer mediated by the MDR1 P-glycoprotein has been associated with poor response to chemotherapy and a shorter overall survival...
  14. INTERACTIONS OF P GLYCOPROTEIN WITH CYTOCHROME P4503A
    Erin Schuetz; Fiscal Year: 2001
    ..Our recent studies have established that the product of the multidrug resistance gene (MDR1), the drug efflux transporter P-glycoprotein (Pgp), influences the pharmacological disposition of rifampicin and is ..
  15. Canine model for assessing CNS access P-gp substrates
    KATRINA MEALEY; Fiscal Year: 2005
    The overall goal of the proposed research is to validate a P-glycoprotein (P-gp) deficient canine model [MDR1(mut/mut)] for delineating the role of P-gp in restricting access of therapeutic agents to the central nervous system (CNS)...
  16. MDR1 GENE THERAPY IN CD34+ CELLS AND SCID MICE
    Susan Kane; Fiscal Year: 2001
    The human MDR1 gene encodes a multispecific drug transporter, P- glycoprotein (Pgp), that prevents drug accumulation in resistant cells. Overexpression of MDR1 is sufficient for conferring multidrug resistance on otherwise normal cells...