ABCA7

Summary

Gene Symbol: ABCA7
Description: ATP binding cassette subfamily A member 7
Alias: ABCA-SSN, ABCX, AD9, ATP-binding cassette sub-family A member 7, ATP-binding cassette, sub-family A (ABC1), member 7, autoantigen SS-N, macrophage ABC transporter
Species: human
Products:     ABCA7

Top Publications

  1. Kim W, Weickert C, Garner B. Role of ATP-binding cassette transporters in brain lipid transport and neurological disease. J Neurochem. 2008;104:1145-66 pubmed
    ..active ABC transporters in the human genome, we have focused on 13 transporters (ABCA1, ABCA2, ABCA3, ABCA4, ABCA7 and ABCA8; ABCB1 and ABCB4; ABCD1 and ABCD2; ABCG1, ABCG2, and ABCG4) for which there is evidence suggesting they ..
  2. Hayashi M, Abe Dohmae S, Okazaki M, Ueda K, Yokoyama S. Heterogeneity of high density lipoprotein generated by ABCA1 and ABCA7. J Lipid Res. 2005;46:1703-11 pubmed
    ..apolipoprotein and cellular lipid was studied using HEK293 cells to which ecdysone-inducible human ABCA1 or human ABCA7 was transfected...
  3. Wang N, Lan D, Gerbod Giannone M, Linsel Nitschke P, Jehle A, Chen W, et al. ATP-binding cassette transporter A7 (ABCA7) binds apolipoprotein A-I and mediates cellular phospholipid but not cholesterol efflux. J Biol Chem. 2003;278:42906-12 pubmed
    ..Based on a high degree of sequence homology between ABCA1 and ABCA7, a transporter of unknown function, we investigated the possibility that ABCA7 might be involved in apolipoprotein ..
  4. Tanaka N, Abe Dohmae S, Iwamoto N, Yokoyama S. Roles of ATP-binding cassette transporter A7 in cholesterol homeostasis and host defense system. J Atheroscler Thromb. 2011;18:274-81 pubmed
    ..b>ABCA7 mediates the formation of HDL when exogenously transfected and expressed; however, endogenous ABCA7 was shown to ..
  5. Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan B, Wang L, et al. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ?4,and the risk of late-onset Alzheimer disease in African Americans. JAMA. 2013;309:1483-92 pubmed publisher
    ..Identification of disease-associated variants helps identify targets for genetic testing, prevention, and treatment...
  6. Jehle A, Gardai S, Li S, Linsel Nitschke P, Morimoto K, Janssen W, et al. ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. J Cell Biol. 2006;174:547-56 pubmed
    ..Using RNA interference or gene targeting, we show that knock down of macrophage ABCA7 but not -A1 results in defective engulfment of apoptotic cells...
  7. Hollingworth P, Harold D, Sims R, Gerrish A, Lambert J, Carrasquillo M, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nat Genet. 2011;43:429-35 pubmed publisher
    ..Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10(-17); including ADGC data, meta P = 5...
  8. Naj A, Jun G, Beecham G, Wang L, Vardarajan B, Buros J, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nat Genet. 2011;43:436-41 pubmed publisher
    ..9 × 10(-8)), BIN1 (rs7561528; P(M) = 4.0 × 10(-14), P(J) = 5.2 × 10(-14)) and PICALM (rs561655; P(M) = 7.0 × 10(-11), P(J) = 1.0 × 10(-10)), but not at EXOC3L2, to late-onset Alzheimer's disease susceptibility. ..
  9. Vasquez J, Fardo D, Estus S. ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status. Neurosci Lett. 2013;556:58-62 pubmed publisher
    ..SNPs within the gene ATP binding cassette A7 (ABCA7) reached significance in these studies, warranting investigation into their actions...

More Information

Publications113 found, 100 shown here

  1. Hughes T, Lopez O, Evans R, Kamboh M, Williamson J, Klunk W, et al. Markers of cholesterol transport are associated with amyloid deposition in the brain. Neurobiol Aging. 2014;35:802-7 pubmed publisher
    ..01), and lower plasma ApoE levels (p = 0.02), and variation in the ABCA7 (p = 0.02) and EPHA1 genes (p = 0.02)...
  2. Wakaumi M, Ishibashi K, Ando H, Kasanuki H, Tsuruoka S. Acute digoxin loading reduces ABCA8A mRNA expression in the mouse liver. Clin Exp Pharmacol Physiol. 2005;32:1034-41 pubmed
    ..Similar reductions in ABCA5, ABCA7, ABCA8b and ABCA9 mRNA were also observed...
  3. Barrera J, Subramanian S, Chiba Falek O. Probing the role of PPARγ in the regulation of late-onset Alzheimer's disease-associated genes. PLoS ONE. 2018;13:e0196943 pubmed publisher
    ..showed changes in mRNA levels of a total of seven genes compared to a control HepG2 cell-line; six of which, ABCA7, APOE, CASS4, CELF1, PTK2B, and ZCWPW1, were upregulated and one, DSG2, was downregulated upon PPARγ knockdown...
  4. Karaca I, Wagner H, Ramirez A. [Search for risk genes in Alzheimer's disease]. Nervenarzt. 2017;88:744-750 pubmed publisher
    ..the risk of AD and rare coding variants (minor allele frequency <1%) located in genes such as TREM2, SORL1, and ABCA7. Thus, progress from genetic research has significantly increased our understanding of the disease mechanisms ..
  5. Hlavata I, Mohelnikova Duchonova B, Vaclavikova R, Liska V, Pitule P, Novak P, et al. The role of ABC transporters in progression and clinical outcome of colorectal cancer. Mutagenesis. 2012;27:187-96 pubmed publisher
    ..of patients treated by adjuvant chemotherapy was significantly shorter in patients with low transcript levels of ABCA7, ABCA13, ABCB4, ABCC11 and ABCD4...
  6. Katsumata Y, Nelson P, Estus S, Fardo D. Translating Alzheimer's disease-associated polymorphisms into functional candidates: a survey of IGAP genes and SNPs. Neurobiol Aging. 2019;74:135-146 pubmed publisher
    ..The IGAP SNPs in ABCA7, CD2AP, and CD33 each acted as eQTL for AD-associated genes in brain...
  7. Ghani M, Lang A, Zinman L, Nacmias B, Sorbi S, Bessi V, et al. Mutation analysis of patients with neurodegenerative disorders using NeuroX array. Neurobiol Aging. 2015;36:545.e9-14 pubmed publisher
    ..In total, we identified 78 potentially damaging rare variants (frequency <1%), including ABCA7 p.L400V in a family with Alzheimer's disease and LRRK2 p.R1514Q in 6 of 98 patients with Parkinson's disease (6...
  8. Mez J, Chung J, Jun G, Kriegel J, Bourlas A, Sherva R, et al. Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans. Alzheimers Dement. 2017;13:119-129 pubmed publisher
    ..the posterior liability and a genome-wide set of single-nucleotide polymorphisms (SNPs), controlling for APOE and ABCA7, identified previously in a LOAD GWAS of AAs. Two SNPs at novel loci, rs112404845 (P = 3...
  9. Humphries C, Kohli M, Whitehead P, Mash D, Pericak Vance M, Gilbert J. Alzheimer disease (AD) specific transcription, DNA methylation and splicing in twenty AD associated loci. Mol Cell Neurosci. 2015;67:37-45 pubmed publisher
    ..Eight loci, prominently ABCA7, contain LOAD specific differences...
  10. Bohm C, Chen F, Sevalle J, Qamar S, Dodd R, Li Y, et al. Current and future implications of basic and translational research on amyloid-β peptide production and removal pathways. Mol Cell Neurosci. 2015;66:3-11 pubmed publisher
    ..late-onset forms of AD are associated with both coding and non-coding variants in genes such as SORL1, PICALM and ABCA7 that affect the production and clearance of Aβ...
  11. Yang A, Gelissen I. ABC-Transporter Mediated Sterol Export from Cells Using Radiolabeled Sterols. Methods Mol Biol. 2017;1583:275-285 pubmed publisher
    ..A number of ATP-binding cassette (ABC) transporters, namely ABCA1, ABCA7, ABCG1, and ABCG4, play an essential role in this process...
  12. Malik M, Parikh I, Vasquez J, Smith C, Tai L, Bu G, et al. Genetics ignite focus on microglial inflammation in Alzheimer's disease. Mol Neurodegener. 2015;10:52 pubmed publisher
    ..We then focus upon six genes implicated by AD genetics that impact microglial function: TREM2, CD33, CR1, ABCA7, SHIP1, and APOE...
  13. Patel A, Rees S, Kelly M, Bain S, Barnett A, Prasher A, et al. Genetic variants conferring susceptibility to Alzheimer's disease in the general population; do they also predispose to dementia in Down's syndrome. BMC Res Notes. 2014;7:42 pubmed publisher
    ..near or within the CR1 (rs3818361), BIN1 (rs744373), CD2AP (rs9349407), EPHA1 (rs11767557), CLU (rs1532278), MS4A6A/4A (rs610932), PICALM (rs561655), ABCA7 (rs3764650) and CD33 (rs3865444) genes were genotyped in 295 individuals with DS.
  14. Nowyhed H, Chandra S, Kiosses W, Marcovecchio P, Andary F, Zhao M, et al. ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content. Sci Rep. 2017;7:40273 pubmed publisher
    b>ABCA7 is an ABC transporter expressed on the plasma membrane, and actively exports phospholipid complexes from the cytoplasmic to the exocytoplasmic leaflet of membranes...
  15. Fehér A, Juhász A, Pakaski M, Janka Z, Kalman J. Association study of the ABCA7 rs3752246 polymorphism in Alzheimer's disease. Psychiatry Res. 2019;: pubmed publisher
    The ATP-binding cassette, sub-family A, member 7 (ABCA7) gene has been identified as a strong genetic risk locus for Alzheimer's disease (AD)...
  16. McQuade A, Blurton Jones M. Microglia in Alzheimer's Disease: Exploring How Genetics and Phenotype Influence Risk. J Mol Biol. 2019;431:1805-1817 pubmed publisher
    ..By studying key Alzheimer's risk genes such as TREM2, CD33, ABCA7, and MS4A6A, we will be able to distinguish true disease-modulatory pathways from the full range of microglial-..
  17. Lamartiniere Y, Boucau M, Dehouck L, Krohn M, Pahnke J, Candela P, et al. ABCA7 Downregulation Modifies Cellular Cholesterol Homeostasis and Decreases Amyloid-β Peptide Efflux in an in vitro Model of the Blood-Brain Barrier. J Alzheimers Dis. 2018;64:1195-1211 pubmed publisher
    The role of ABCA7 in brain homeostasis and Alzheimer's disease (AD) is currently under intense scrutiny, since it has been reported that polymorphisms in the Abca7 gene and a loss of function of the protein are closely linked to ..
  18. Le Guennec K, Nicolas G, Quenez O, Charbonnier C, Wallon D, Bellenguez C, et al. ABCA7 rare variants and Alzheimer disease risk. Neurology. 2016;86:2134-7 pubmed publisher
    To study the association between ABCA7 rare coding variants and Alzheimer disease (AD) in a case-control setting. We conducted a whole exome analysis among 484 French patients with early-onset AD and 590 ethnically matched controls...
  19. Chen J, Zheng Y, Xu C, Gu L, Ding Z, Qin L, et al. Valproic acid (VPA) enhances cisplatin sensitivity of non-small cell lung cancer cells via HDAC2 mediated down regulation of ABCA1. Biol Chem. 2017;398:785-792 pubmed publisher
    ..VPA treatment markedly decreased the mRNA and protein levels of ABCA1, while had no significant effect on ABCA3, ABCA7 or ABCB10...
  20. Logge W, Cheng D, Chesworth R, Bhatia S, Garner B, Kim W, et al. Role of Abca7 in mouse behaviours relevant to neurodegenerative diseases. PLoS ONE. 2012;7:e45959 pubmed publisher
    ..Recent studies suggest that the ABC transporter ABCA7 may play a role in the development of brain disorders such as schizophrenia and Alzheimer's disease...
  21. Quazi F, Molday R. Differential phospholipid substrates and directional transport by ATP-binding cassette proteins ABCA1, ABCA7, and ABCA4 and disease-causing mutants. J Biol Chem. 2013;288:34414-26 pubmed publisher
    ABCA1, ABCA7, and ABCA4 are members of the ABCA subfamily of ATP-binding cassette transporters that share extensive sequence and structural similarity...
  22. Hotta N, Abe Dohmae S, Taguchi R, Yokoyama S. Preferential incorporation of shorter and less unsaturated acyl phospholipids into high density lipoprotein-like particles in the ABCA1- and ABCA7-mediated biogenesis with apoA-I. Chem Phys Lipids. 2015;187:1-9 pubmed publisher
    ..apolipoprotein A-I (apoA-I) form HEK293 cells where either human ATP binding cassette transporter (ABC) A1 or ABCA7 was transfected and overexpressed...
  23. Andrews S, Das D, Cherbuin N, Anstey K, Easteal S. Association of genetic risk factors with cognitive decline: the PATH through life project. Neurobiol Aging. 2016;41:150-158 pubmed publisher
    ..Significant associations with cognitive performance were observed for APOE ?4 allele, ABCA7-rs3764650, CR1-rs3818361, MS4A4E-rs6109332, BDNF-rs6265, COMT-rs4680, CTNNBL-rs6125962, FRMD4A-rs17314229, FRMD4A-..
  24. Huber Mollema Y, van Iterson L, Sander J, Oort F, Lindhout D, Rodenburg R. Exposure to antiepileptic drugs in pregnancy: The need for a family factor framework. Epilepsy Behav. 2018;86:187-192 pubmed publisher
    ..A family factor framework (the ABCX model) served as the basis to review distinct family factors in children who were exposed to AEDs in pregnancy...
  25. Sasaki M, Shoji A, Kubo Y, Nada S, Yamaguchi A. Cloning of rat ABCA7 and its preferential expression in platelets. Biochem Biophys Res Commun. 2003;304:777-82 pubmed
    We cloned the full-length cDNA of a rat orthologue of ABCA7 (rABCA7) from rat platelets. The cDNA of rABCA7 is 6510bp in length and encodes a protein of 2170 amino acids...
  26. Kim W, Li H, Ruberu K, Chan S, Elliott D, Low J, et al. Deletion of Abca7 increases cerebral amyloid-? accumulation in the J20 mouse model of Alzheimer's disease. J Neurosci. 2013;33:4387-94 pubmed publisher
    ATP-binding cassette transporter A7 (ABCA7) is expressed in the brain and has been detected in macrophages, microglia, and neurons...
  27. Kimura M, Yamazaki Y. Mental health and positive change among Japanese mothers of children with intellectual disabilities: Roles of sense of coherence and social capital. Res Dev Disabil. 2016;59:43-54 pubmed publisher
    ..change among mothers of children with intellectual disabilities in Japan based on the concept of the Double ABCX model...
  28. Yang P, Sun Y, Liu Z, Tao Q, Li H, Lu S, et al. Association study of ABCA7 and NPC1 polymorphisms with Alzheimer's disease in Chinese Han ethnic population. Psychiatr Genet. 2013;23:268 pubmed publisher
  29. Wachinger C, Nho K, Saykin A, Reuter M, Rieckmann A. A Longitudinal Imaging Genetics Study of Neuroanatomical Asymmetry in Alzheimer's Disease. Biol Psychiatry. 2018;84:522-530 pubmed publisher
    ..between asymmetry of the amygdala, hippocampus, and putamen and SNPs in the genes BIN1, CD2AP, ZCWPW1, ABCA7, TNKS, and DLG2 were found...
  30. Villegas Llerena C, Phillips A, Garcia Reitboeck P, Hardy J, Pocock J. Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease. Curr Opin Neurobiol. 2016;36:74-81 pubmed publisher
    ..The findings strongly implicate genes related to the immune response (CR1, CD33, MS4A, CLU, ABCA7, EPHA1 and HLA-DRB5-HLA-DRB1), endocytosis (BIN1, PICALM, CD2AP, EPHA1 and SORL1) and lipid biology (CLU, ABCA7 ..
  31. Frishman N, Conway K, Andrews J, Oleson J, Mathews K, Ciafaloni E, et al. Perceived quality of life among caregivers of children with a childhood-onset dystrophinopathy: a double ABCX model of caregiver stressors and perceived resources. Health Qual Life Outcomes. 2017;15:33 pubmed publisher
    ..Bivariate and multivariate analyses examined associations between study variables using the Double ABCX model as an analytic framework...
  32. Efthymiou A, Goate A. Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk. Mol Neurodegener. 2017;12:43 pubmed publisher
    ..Of these genes, several (including CR1, SPI1, the MS4As, TREM2, ABCA7, CD33, and INPP5D) are expressed by microglia, the resident immune cells of the brain...
  33. Schott J, Crutch S, Carrasquillo M, Uphill J, Shakespeare T, Ryan N, et al. Genetic risk factors for the posterior cortical atrophy variant of Alzheimer's disease. Alzheimers Dement. 2016;12:862-71 pubmed publisher
    ..83, P = .0007). We found evidence for risk in/near CR1 (P = 7 × 10(-4)), ABCA7 (P = .02) and BIN1 (P = .04)...
  34. Broccardo C, Osorio J, Luciani M, Schriml L, Prades C, Shulenin S, et al. Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter. Cytogenet Cell Genet. 2001;92:264-70 pubmed
    ..genomic and transcriptional characterization in mouse and man of a novel transporter of the ABCA subclass, named ABCA7. As it is the case for other ABCA genes, the predicted protein encoded by ABCA7 is a full symmetric transporter, ..
  35. Sassi C, Nalls M, Ridge P, Gibbs J, Ding J, Lupton M, et al. ABCA7 p.G215S as potential protective factor for Alzheimer's disease. Neurobiol Aging. 2016;46:235.e1-9 pubmed publisher
    ..coding variants in 9 AD GWAS loci with the strongest effect sizes after APOE (BIN1, CLU, CR1, PICALM, MS4A6A, ABCA7, EPHA1, CD33, and CD2AP) in a cohort of 332 sporadic AD cases and 676 elderly controls of British and North-..
  36. Del Aguila J, Fernández M, Jimenez J, Black K, Ma S, Deming Y, et al. Role of ABCA7 loss-of-function variant in Alzheimer's disease: a replication study in European-Americans. Alzheimers Res Ther. 2015;7:73 pubmed publisher
    A recent study found a significant increase of ABCA7 loss-of-function variants in Alzheimer's disease (AD) cases compared to controls. Some variants were located on noncoding regions, but it was demonstrated that they affect splicing...
  37. Aikawa T, Holm M, Kanekiyo T. ABCA7 and Pathogenic Pathways of Alzheimer's Disease. Brain Sci. 2018;8: pubmed publisher
    ..b>ABCA7 belongs to the A subfamily of ABC transporters, which shares 54% sequence identity with ABCA1...
  38. Morales C, Ni X, Smith C, Inagaki N, Hermo L. ABCA17 mediates sterol efflux from mouse spermatozoa plasma membranes. Histol Histopathol. 2012;27:317-28 pubmed publisher
    ..Candidates include members of the ATP-binding cassette (ABC) transporter superfamily including ABCA1, ABCA7, ABCA17, and ABCG1...
  39. Lin E, Tsai S, Kuo P, Liu Y, Yang A, Kao C. Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. Oncotarget. 2017;8:24077-24087 pubmed publisher
    ..meta-analyses implicated that increased risk of developing Alzheimer's diseases (AD) has been associated with the ABCA7, APOE, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB1, HLA-DRB4, INPP5D, MEF2C, MS4A4A, ..
  40. Almeida J, Dos Santos L, Trancozo M, de Paula F. Updated Meta-Analysis of BIN1, CR1, MS4A6A, CLU, and ABCA7 Variants in Alzheimer's Disease. J Mol Neurosci. 2018;64:471-477 pubmed publisher
    ..Among those, rs3764650 ABCA7, rs6656401 CR1, and rs744373 BIN1 were associated as risk factors for LOAD, while rs11136000 CLU and rs610932 ..
  41. Dorszewska J, Prendecki M, Oczkowska A, Dezor M, Kozubski W. Molecular Basis of Familial and Sporadic Alzheimer's Disease. Curr Alzheimer Res. 2016;13:952-63 pubmed
    ..molecular factors related to the immunological cause (TREM2) of the disease are a disorder of the lipid (ABCA1, ABCA7) or biothiol (MTHFD1) metabolism and of the transport of metabolites (BIN1)...
  42. Sakae N, Liu C, Shinohara M, Frisch Daiello J, Ma L, Yamazaki Y, et al. ABCA7 Deficiency Accelerates Amyloid-? Generation and Alzheimer's Neuronal Pathology. J Neurosci. 2016;36:3848-59 pubmed publisher
    ..b>ABCA7 is homologous to a major lipid transporter ABCA1 and is highly expressed in neurons and microglia in the brain...
  43. Tomioka M, Toda Y, Mañucat N, Akatsu H, Fukumoto M, Kono N, et al. Lysophosphatidylcholine export by human ABCA7. Biochim Biophys Acta Mol Cell Biol Lipids. 2017;1862:658-665 pubmed publisher
    The ATP-binding cassette transporter A7 (ABCA7), which is highly expressed in the brain, is associated with the pathogenesis of Alzheimer's disease (AD)...
  44. Tanaka N, Abe Dohmae S, Iwamoto N, Fitzgerald M, Yokoyama S. HMG-CoA reductase inhibitors enhance phagocytosis by upregulating ATP-binding cassette transporter A7. Atherosclerosis. 2011;217:407-14 pubmed publisher
    ..We therefore examined the effect of statins on phagocytosis in vitro and in vivo through the SREBP-ABCA7. Phagocytosis was found to be enhanced by pravastatin, rosuvastatin and simvastatin and cyclodextrin in J774 ..
  45. Vasquez J, Simpson J, Harpole R, Estus S. Alzheimer's Disease Genetics and ABCA7 Splicing. J Alzheimers Dis. 2017;59:633-641 pubmed publisher
    Both common and rare polymorphisms within ABCA7 have been associated with Alzheimer's disease (AD)...
  46. Wang Y, Tang B, Yang Y, Cui Y, Kang J, Liu Z, et al. Relationship between Alzheimer's disease GWAS-linked top hits and risk of Parkinson's disease with or without cognitive decline: a Chinese population-based study. Neurobiol Aging. 2016;39:217.e9-11 pubmed publisher
    ..with both PD and cognitive function in PD, investigating 13 single-nucleotide polymorphisms in 9 genes (BIN1, CLU, ABCA7, CR1, PICALM, MS4A6A, CD33, MS4A4E, and CD2AP)...
  47. Krakovich T, McGrew J, Yu Y, Ruble L. Stress in Parents of Children with Autism Spectrum Disorder: An Exploration of Demands and Resources. J Autism Dev Disord. 2016;46:2042-2053 pubmed publisher
    We applied the ABCX model of stress and coping to assess the association between child and family demands, school-based resources (i.e...
  48. Barrera A, García E, Hamdi M, Sánchez Calabuig M, López Cardona Ã, Balvís N, et al. Embryo culture in presence of oviductal fluid induces DNA methylation changes in bovine blastocysts. Reproduction. 2017;154:1-12 pubmed publisher
    ..Genomic regions in four developmentally important genes (MTERF2, ABCA7, OLFM1, GMDS) and within LINE-1 retrotransposons were selected for methylation analysis by ..
  49. Kaminski W, Piehler A, Schmitz G. Genomic organization of the human cholesterol-responsive ABC transporter ABCA7: tandem linkage with the minor histocompatibility antigen HA-1 gene. Biochem Biophys Res Commun. 2000;278:782-9 pubmed
    We have recently cloned a novel cholesterol-responsive ABC transporter, designated ABCA7, which is predominantly expressed in human leukocytes. Here we report the structure of the human ABCA7 gene...
  50. Chan S, Kim W, Kwok J, Hill A, Cappai R, Rye K, et al. ATP-binding cassette transporter A7 regulates processing of amyloid precursor protein in vitro. J Neurochem. 2008;106:793-804 pubmed publisher
    ATP-binding cassette transporter A7 (ABCA7) is expressed in the brain and, like its closest homolog ABCA1, belongs to the ABCA subfamily of full-length ABC transporters...
  51. Hesamzadeh A, Dalvandi A, Bagher Maddah S, Fallahi Khoshknab M, Ahmadi F. Family Adaptation to Stroke: A Metasynthesis of Qualitative Research based on Double ABCX Model. Asian Nurs Res (Korean Soc Nurs Sci). 2015;9:177-84 pubmed publisher
    ..of research into subjective experience of families with stroke survivors based on the components of the Double ABCX Model including stressors, resources, perception, coping strategies, and adaptation of these families...
  52. Nettiksimmons J, TRANAH G, Evans D, Yokoyama J, Yaffe K. Gene-based aggregate SNP associations between candidate AD genes and cognitive decline. Age (Dordr). 2016;38:41 pubmed publisher
    Single nucleotide polymorphisms (SNPs) in and near ABCA7, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, complement receptor 1 (CR1), EPHA1, EXOC3L2, FERMT2, HLA cluster (DRB5-DQA), INPP5D, MEF2C, MS4A cluster (MS4A3-MS4A6E), NME8, PICALM, PTK2B, ..
  53. Roshchupkin G, Adams H, van der Lee S, Vernooij M, van Duijn C, Uitterlinden A, et al. Fine-mapping the effects of Alzheimer's disease risk loci on brain morphology. Neurobiol Aging. 2016;48:204-211 pubmed publisher
    ..Brain regions most significantly associated with AD risk variants were the left postcentral gyrus with ABCA7 (rs4147929, p = 4.45 × 10-6), right superior frontal gyrus by ZCWPW1 (rs1476679, p = 5...
  54. Tanaka A, Ikeda Y, Abe Dohmae S, Arakawa R, Sadanami K, Kidera A, et al. Human ABCA1 contains a large amino-terminal extracellular domain homologous to an epitope of Sjögren's Syndrome. Biochem Biophys Res Commun. 2001;283:1019-25 pubmed
    ..We found that this amino-terminal extracellular domain contains a segment homologous to the autoantigen SS-N, an epitope of Sjögren's syndrome, and further identified that ABCA7 codes for the autoantigen SS-N.
  55. Kim W, Guillemin G, Glaros E, Lim C, Garner B. Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells. Neuroreport. 2006;17:891-6 pubmed
    Five ATP-binding cassette (ABC) subfamily-A transporters (ABCA1, ABCA2, ABCA3, ABCA7 and ABCA8) are expressed in the brain...
  56. Iwamoto N, Abe Dohmae S, Sato R, Yokoyama S. ABCA7 expression is regulated by cellular cholesterol through the SREBP2 pathway and associated with phagocytosis. J Lipid Res. 2006;47:1915-27 pubmed
    b>ABCA7 is highly homologous to ABCA1 and mediates cellular cholesterol and phospholipid release by apolipoproteins when transfected in vitro...
  57. Wu C, Wang N, Zhao D. An evaluation of the mechanism of ABCA7 on cellular lipid release in ABCA7-HEC293 cell. Chin Med J (Engl). 2013;126:306-10 pubmed
    b>ABCA7 is a member of the ABCA subfamily that shows a high degree of homology to ABCA1 and, like ABCA1, mediates cellular cholesterol and phospholipid release by apolipoproteins when transfected in vitro...
  58. Engelman C, Koscik R, Jonaitis E, Okonkwo O, Hermann B, La Rue A, et al. Interaction between two cholesterol metabolism genes influences memory: findings from the Wisconsin Registry for Alzheimer's Prevention. J Alzheimers Dis. 2013;36:749-57 pubmed publisher
    ..Interactions between the APOE ?4 allele and both of the genotyped ABCA7 SNPs, rs3764650 and rs3752246, were associated with all three cognitive factor scores (p-values ? 0.01)...
  59. Niwa M, Maruyama H, Fujimoto T, Dohi K, Maruyama I. Affinity selection of cDNA libraries by lambda phage surface display. Gene. 2000;256:229-36 pubmed
    ..Thus, the bacteriophage lambda surface display is powerful for isolating cDNA clones by affinity screening. ..
  60. Abe Dohmae S, Ikeda Y, Matsuo M, Hayashi M, Okuhira K, Ueda K, et al. Human ABCA7 supports apolipoprotein-mediated release of cellular cholesterol and phospholipid to generate high density lipoprotein. J Biol Chem. 2004;279:604-11 pubmed
    ..cholesterol and phospholipids was induced in HEK293 cells by expressing human ATP-binding cassette transporter A7 (ABCA7) and ABC transporter A1 (ABCA1) proteins, whether transient or stable, to generate cholesterol-rich high density ..
  61. Harangi M, Kaminski W, Fleck M, Orso E, Zeher M, Kiss E, et al. Homozygosity for the 168His variant of the minor histocompatibility antigen HA-1 is associated with reduced risk of primary Sjögren's syndrome. Eur J Immunol. 2005;35:305-17 pubmed
    The genes for the human ATP-binding cassette (ABC) transporter ABCA7 and the minor histocompatibility antigen HA-1 are juxtaposed in close proximity on chromosome 19p13.3...
  62. Chen X, Sun C, Chen Q, O Neill F, Walsh D, Fanous A, et al. Apoptotic engulfment pathway and schizophrenia. PLoS ONE. 2009;4:e6875 pubmed publisher
    ..In this study, we followed the apoptotic engulfment pathway involving the MEGF10, GULP1, ABCA1 and ABCA7 genes and tested their association with the disease.
  63. Liu G, Li F, Zhang S, Jiang Y, Ma G, Shang H, et al. Analyzing large-scale samples confirms the association between the ABCA7 rs3764650 polymorphism and Alzheimer's disease susceptibility. Mol Neurobiol. 2014;50:757-64 pubmed publisher
    Large-scale genome-wide association studies (GWAS) have revealed that the ABCA7 rs3764650 polymorphism (or its proxies, namely rs115550680, rs3752246, and rs4147929) is associated with Alzheimer's disease (AD) susceptibility in ..
  64. Elsnerova K, Bartakova A, Tihlarik J, Bouda J, Rob L, Skapa P, et al. Gene Expression Profiling Reveals Novel Candidate Markers of Ovarian Carcinoma Intraperitoneal Metastasis. J Cancer. 2017;8:3598-3606 pubmed publisher
    ..Gene expression of ABCA7 significantly increased and that of ESR2 decreased in the order control ovarian tissues - primary EOCs -..
  65. Abe Dohmae S, Ueda K, Yokoyama S. ABCA7, a molecule with unknown function. FEBS Lett. 2006;580:1178-82 pubmed
    Many ABC proteins are functional in cellular lipid transport in various different manners. ABCA7 is a full-size ABC transporter, the physiological function of which is unknown to date...
  66. Mani O, Korner M, Sorensen M, Sejrsen K, Wotzkow C, Ontsouka C, et al. Expression, localization, and functional model of cholesterol transporters in lactating and nonlactating mammary tissues of murine, bovine, and human origin. Am J Physiol Regul Integr Comp Physiol. 2010;299:R642-54 pubmed publisher
    ..lipid homeostasis and mammary gland (MG) physiology, we compared expression and localization of ABCA1, ABCG1, and ABCA7 and their regulatory genes in mammary tissues of different species during the pregnancy-lactation cycle...
  67. Liu L, Xu J, Deng Y, Tang H, Wang Y, Ren R, et al. A complex association of ABCA7 genotypes with sporadic Alzheimer disease in Chinese Han population. Alzheimer Dis Assoc Disord. 2014;28:141-4 pubmed publisher
    ..large genome-wide association study has revealed that polymorphism of alleles and genotypes in rs3,764,650 within ABCA7 gene is associated with Alzheimer disease in whites...
  68. Chung S, Kim M, Kim Y, Kim J, You S, Jang E, et al. CR1, ABCA7, and APOE genes affect the features of cognitive impairment in Alzheimer's disease. J Neurol Sci. 2014;339:91-6 pubmed publisher
    ..We aimed to investigate the association between top hits of genome-wide association studies (GWAS) and specific cognitive domains in AD patients...
  69. Jamal S, Goyal S, Shanker A, Grover A. Computational Screening and Exploration of Disease-Associated Genes in Alzheimer's Disease. J Cell Biochem. 2017;118:1471-1479 pubmed publisher
    ..methods to examine the pathogenic effects of non-synonymous single nucleotide polymorphisms (SNPs) associated with ABCA7, CR1, MS4A6A, CD2AP, PSEN1, PSEN2, and APP genes...
  70. Schultz S, Boots E, Darst B, Zetterberg H, Blennow K, Edwards D, et al. Cardiorespiratory fitness alters the influence of a polygenic risk score on biomarkers of AD. Neurology. 2017;88:1650-1658 pubmed publisher
    To examine whether a polygenic risk score (PRS) derived from APOE4, CLU, and ABCA7 is associated with CSF biomarkers of Alzheimer disease (AD) pathology and whether higher cardiorespiratory fitness (CRF) modifies the ..
  71. Kaminski W, Piehler A, Püllmann K, Porsch Ozcurumez M, Duong C, Bared G, et al. Complete coding sequence, promoter region, and genomic structure of the human ABCA2 gene and evidence for sterol-dependent regulation in macrophages. Biochem Biophys Res Commun. 2001;281:249-58 pubmed
    ..ABCA2 shares highest homology with the cholesterol-responsive transporters ABCA1 (50%) and the recently cloned ABCA7 (44%). The ABCA2 gene comprises 48 exons which are localized within a genomic region of only 21 kb...
  72. Van den Bossche T, Sleegers K, Cuyvers E, Engelborghs S, Sieben A, De Roeck A, et al. Phenotypic characteristics of Alzheimer patients carrying an ABCA7 mutation. Neurology. 2016;86:2126-33 pubmed publisher
    To generate a clinical and pathologic phenotype of patients carrying rare loss-of-function mutations in ABCA7, identified in a Belgian Alzheimer patient cohort and in an autosomal dominant family...
  73. Li M, Yuan Y, Hu B, Wu L. Study on Lentivirus-Mediated ABCA7 Improves Neurocognitive Function and Related Mechanisms in the C57BL/6 Mouse Model of Alzheimer's Disease. J Mol Neurosci. 2017;61:489-497 pubmed publisher
    ATP-binding cassette transporter A7 (ABCA7) is expressed in the hippocampus and cortex of the brain and was confirmed to be involved in the development of Alzheimer's disease (AD)...
  74. Logue M, Schu M, Vardarajan B, Farrell J, Lunetta K, Jun G, et al. Search for age-related macular degeneration risk variants in Alzheimer disease genes and pathways. Neurobiol Aging. 2014;35:1510.e7-18 pubmed publisher
    ..14, p = 2.34 × 10(-6)), and with ABCA7 (peak AMD SNP rs3752228, MAF = 0.054, OR = 1.22, p = 0.00012)...
  75. Bamji Mirza M, Li Y, Najem D, Liu Q, Walker D, Lue L, et al. Genetic Variations in ABCA7 Can Increase Secreted Levels of Amyloid-?40 and Amyloid-?42 Peptides and ABCA7 Transcription in Cell Culture Models. J Alzheimers Dis. 2016;53:875-92 pubmed publisher
    Alzheimer's disease (AD) is characterized by extracellular deposits of amyloid-? (A?) in the brain. ABCA7 is highly expressed in the brain and a susceptibility gene for late-onset AD (LOAD)...
  76. Volmar C, Salah Uddin H, Janczura K, Halley P, Lambert G, Wodrich A, et al. M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory. Proc Natl Acad Sci U S A. 2017;114:E9135-E9144 pubmed publisher
    ..increases the expression of AD-relevant genes: BDNF, ?-secretase (ADAM10), MINT2, FE65, REST, SIRT1, BIN1, and ABCA7, among others...
  77. Kim W, Fitzgerald M, Kang K, Okuhira K, Bell S, Manning J, et al. Abca7 null mice retain normal macrophage phosphatidylcholine and cholesterol efflux activity despite alterations in adipose mass and serum cholesterol levels. J Biol Chem. 2005;280:3989-95 pubmed
    ..Although the functions of the other 10 ABCA class transporters identified in the human genome remain obscure, ABCA7-transfected cells have been shown to efflux lipids in response to stimulation by apolipoprotein A-I...
  78. Cuyvers E, De Roeck A, Van den Bossche T, Van Cauwenberghe C, Bettens K, Vermeulen S, et al. Mutations in ABCA7 in a Belgian cohort of Alzheimer's disease patients: a targeted resequencing study. Lancet Neurol. 2015;14:814-822 pubmed publisher
    b>ABCA7 was identified as a risk gene for Alzheimer's disease in genome-wide association studies (GWAS). It was one of the genes most strongly associated with risk of Alzheimer's disease in a Belgian cohort...
  79. Ohtsuki S, Kamoi M, Watanabe Y, Suzuki H, Hori S, Terasaki T. Correlation of induction of ATP binding cassette transporter A5 (ABCA5) and ABCB1 mRNAs with differentiation state of human colon tumor. Biol Pharm Bull. 2007;30:1144-6 pubmed
    ..ABCA6 mRNA was detected in lung and liver, and ABCA8 was detected in lung. ABCA6, ABCA7 and ABCA8 mRNAs were not detected in any tumors, but weak mRNA expression of ABCA10 was detected in all tumors ..
  80. Hohman T, Cooke Bailey J, Reitz C, Jun G, Naj A, Beecham G, et al. Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimers Dement. 2016;12:233-43 pubmed publisher
    ..g., APOE, ABCA7) differed substantially from previous studies in EA...
  81. Kielar D, Kaminski W, Liebisch G, Piehler A, Wenzel J, Möhle C, et al. Adenosine triphosphate binding cassette (ABC) transporters are expressed and regulated during terminal keratinocyte differentiation: a potential role for ABCA7 in epidermal lipid reorganization. J Invest Dermatol. 2003;121:465-74 pubmed
    ..The recently cloned transporter ABCA7 was highly expressed in keratinocytes and HaCaT cells and upregulated during differentiation...
  82. Fitzgerald M, Okuhira K, Short G, Manning J, Bell S, Freeman M. ATP-binding cassette transporter A1 contains a novel C-terminal VFVNFA motif that is required for its cholesterol efflux and ApoA-I binding activities. J Biol Chem. 2004;279:48477-85 pubmed
    ..Chimeric transporters, generated by substituting the C termini of either ABCA4 or ABCA7 for the endogenous terminus, demonstrated that ABCA1 could stimulate cholesterol efflux without its PDZ-binding ..
  83. Zhao Q, Wan Y, Wang H, Sun F, Hao X, Tan M, et al. ABCA7 Genotypes Confer Alzheimer's Disease Risk by Modulating Amyloid-? Pathology. J Alzheimers Dis. 2016;52:693-703 pubmed publisher
    b>ABCA7 gene has been identified as a strong genetic locus for Alzheimer's disease (AD) susceptibility in genome wide association studies (GWAS). However, the possible roles of ABCA7 variants in AD pathology were not specifically assessed...
  84. Li H, Zhou J, Yue Z, Feng L, Luo Z, Chen S, et al. A complex association between ABCA7 genotypes and blood lipid levels in Southern Chinese Han patients of sporadic Alzheimer's disease. J Neurol Sci. 2017;382:13-17 pubmed publisher
    ..ATP-binding cassette transporter A7 (ABCA7) gene, regulating the transport of cholesterol, has been recently identified as a susceptible gene of AD by ..
  85. Iida A, Saito S, Sekine A, Mishima C, Kitamura Y, Kondo K, et al. Catalog of 605 single-nucleotide polymorphisms (SNPs) among 13 genes encoding human ATP-binding cassette transporters: ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8. J Hum Genet. 2002;47:285-310 pubmed
    ..additional loci, specifically 13 genes belonging to the superfamily of ATP-binding cassette transporters ( ABCA4, ABCA7, ABCA8, ABCD1, ABCD3, ABCD4, ABCE1, ABCF1, ABCG1, ABCG2, ABCG4, ABCG5, and ABCG8)...
  86. Meurs I, Calpe Berdiel L, Habets K, Zhao Y, Korporaal S, Mommaas A, et al. Effects of deletion of macrophage ABCA7 on lipid metabolism and the development of atherosclerosis in the presence and absence of ABCA1. PLoS ONE. 2012;7:e30984 pubmed publisher
    b>ABCA7, a close relative of ABCA1 which facilitates cholesterol efflux to lipid-poor apoproteins, has been implicated in macrophage lipid efflux and clearance of apoptotic cells in in vitro studies...
  87. Martiskainen H, Herukka S, Stancakova A, Paananen J, Soininen H, Kuusisto J, et al. Decreased plasma ?-amyloid in the Alzheimer's disease APP A673T variant carriers. Ann Neurol. 2017;82:128-132 pubmed publisher
    We investigated the association of Alzheimer's disease (AD)-related rare variants APP A673T and ABCA7 rs200538373-C with the levels of ?-amyloid (A?) and parameters of metabolic and cardiovascular health in a population-based cohort of ..
  88. Morales C, Marat A, Ni X, Yu Y, Oko R, Smith B, et al. ATP-binding cassette transporters ABCA1, ABCA7, and ABCG1 in mouse spermatozoa. Biochem Biophys Res Commun. 2008;376:472-7 pubmed publisher
    ..Candidate transporters are members of the ATP-binding cassette (ABC) transporter superfamily including ABCA1, ABCA7, ABCG1 and ABCG4, which have all been implicated in the transport of sterols and phospholipids to apolipoproteins ..
  89. Rosenthal S, Barmada M, Wang X, Demirci F, Kamboh M. Connecting the dots: potential of data integration to identify regulatory SNPs in late-onset Alzheimer's disease GWAS findings. PLoS ONE. 2014;9:e95152 pubmed publisher
    ..score <3), and only 3 of them were genome-wide significant SNPs (ZCWPW1/rs1476679, CLU/rs1532278 and ABCA7/rs3764650)...
  90. Satoh K, Abe Dohmae S, Yokoyama S, St George Hyslop P, Fraser P. ATP-binding cassette transporter A7 (ABCA7) loss of function alters Alzheimer amyloid processing. J Biol Chem. 2015;290:24152-65 pubmed publisher
    The ATP-binding cassette transporter A7 (ABCA7) has been identified as a susceptibility factor of late onset Alzheimer disease in genome-wide association studies...
  91. Li H, Karl T, Garner B. Abca7 deletion does not affect adult neurogenesis in the mouse. Biosci Rep. 2016;36: pubmed publisher
    ATP-binding cassette transporter A7 (ABCA7) is highly expressed in the brain...
  92. Kaminski W, Orso E, Diederich W, Klucken J, Drobnik W, Schmitz G. Identification of a novel human sterol-sensitive ATP-binding cassette transporter (ABCA7). Biochem Biophys Res Commun. 2000;273:532-8 pubmed
    ..In accordance with the currently proposed classification, the novel transporter was designated ABCA7. ABCA7 mRNA was detected predominantly in myelo-lymphatic tissues with highest expression in peripheral leukocytes,..