ABC7

Summary

Gene Symbol: ABC7
Description: ATP binding cassette subfamily B member 7
Alias: ABC7, ASAT, Atm1p, EST140535, ATP-binding cassette sub-family B member 7, mitochondrial, ABC transporter 7 protein, ATP-binding cassette transporter 7, ATP-binding cassette, sub-family B (MDR/TAP), member 7
Species: human
Products:     ABC7

Top Publications

  1. Kispal G, Csere P, Prohl C, Lill R. The mitochondrial proteins Atm1p and Nfs1p are essential for biogenesis of cytosolic Fe/S proteins. EMBO J. 1999;18:3981-9 pubmed
    ..The ATP-binding cassette (ABC) transporter Atm1p of the mitochondrial inner membrane performs an essential function only in the generation of cytosolic Fe/S ..
  2. Allikmets R, Raskind W, Hutchinson A, Schueck N, Dean M, Koeller D. Mutation of a putative mitochondrial iron transporter gene (ABC7) in X-linked sideroblastic anemia and ataxia (XLSA/A). Hum Mol Genet. 1999;8:743-9 pubmed
    ..This gene, ABC7, is an ortholog of the yeast ATM1 gene whose product localizes to the mitochondrial inner membrane and is involved ..
  3. Bekri S, Kispal G, Lange H, Fitzsimons E, Tolmie J, Lill R, et al. Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation. Blood. 2000;96:3256-64 pubmed
    ..ABC7 belongs to the adenosine triphosphate-binding cassette transporter superfamily, and its yeast orthologue, Atm1p, plays a central role in the maturation of cytosolic iron-sulfur (Fe/S) cluster-containing proteins...
  4. Shimada Y, Okuno S, Kawai A, Shinomiya H, Saito A, Suzuki M, et al. Cloning and chromosomal mapping of a novel ABC transporter gene (hABC7), a candidate for X-linked sideroblastic anemia with spinocerebellar ataxia. J Hum Genet. 1998;43:115-22 pubmed
    ..human ATP-binding cassette (ABC) transporter cDNA, determined its nucleotide sequence, and designated it human ABC7 (hABC7)...
  5. Auger F, Martin F, Petrault O, Samaillie J, Hennebelle T, Trabelsi M, et al. Risperidone-induced metabolic dysfunction is attenuated by Curcuma longa extract administration in mice. Metab Brain Dis. 2018;33:63-77 pubmed publisher
    ..Curcumin decreased risperidone-induced increases in serum markers of hepatotoxicity (ALAT, ASAT), as well as of one major hepatic pro-inflammatory transcription factor (NF?B: p105 mRNA and p65 protein)...
  6. Camaschella C. Hereditary sideroblastic anemias: pathophysiology, diagnosis, and treatment. Semin Hematol. 2009;46:371-7 pubmed publisher
  7. Drouet J, Fauvelle F, Maunoir Regimbal S, Fidier N, Maury R, Peinnequin A, et al. Differences in prefrontal cortex GABA/glutamate ratio after acute restraint stress in rats are associated with specific behavioral and neurobiological patterns. Neuroscience. 2015;285:155-65 pubmed publisher
    ..stress with an enhanced rise in corticosterone, alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), creatine kinase (CK) and lactate dehydrogenase (LDH) levels, as well as behavioral disturbances with decreased ..
  8. Bergmann A, Campagna D, McLoughlin E, Agarwal S, Fleming M, Bottomley S, et al. Systematic molecular genetic analysis of congenital sideroblastic anemia: evidence for genetic heterogeneity and identification of novel mutations. Pediatr Blood Cancer. 2010;54:273-8 pubmed publisher
    ..Despite these known diverse causes, in a substantial portion of CSA cases a presumed genetic defect remains unknown...
  9. Soussi R, Hfaiedh N, Guesmi F, Sakly M, Ben Rhouma K. Hepatoprotective and antioxidant properties of the aqueous extract of Olea europaea leaves against Diclofenac-induced liver damages in mice. Appl Physiol Nutr Metab. 2018;: pubmed publisher
    ..a increasing in the levels of cholesterol, triglyceride, glucose, creatinine, urea, aspartate aminotransferase (ASAT), and alanine aminotransferase (ALAT)...

More Information

Publications97

  1. Fahmy S. Anti-fibrotic effect of Holothuria arenicola extract against bile duct ligation in rats. BMC Complement Altern Med. 2015;15:14 pubmed publisher
    ..decreasing the levels of total conjugated and unconjugated bilirubin and the activities of serum aminotransferases (ASAT and ALAT) and alkaline phosphatase (ALP) as well as malondialdehyde (MDA) level, and increasing the serum albumin, ..
  2. Souayed N, Chennoufi M, Boughattas F, Haouas Z, Maaroufi K, Miled A, et al. Circadian variation in murine hepatotoxicity to the antituberculosis agent «Isoniazide». Chronobiol Int. 2015;32:1201-10 pubmed publisher
    ..assessed by the significant increase in both serum transaminase (ALAT: alanine aminotransferase) and (ASAT: aspartate aminotransferase) and antioxidant enzyme activities (catalase: CAT and superoxide dismutase: SOD)...
  3. Dolatshad H, Pellagatti A, Fernandez Mercado M, Yip B, Malcovati L, Attwood M, et al. Disruption of SF3B1 results in deregulated expression and splicing of key genes and pathways in myelodysplastic syndrome hematopoietic stem and progenitor cells. Leukemia. 2015;29:1092-103 pubmed publisher
  4. Zogheib E, Cosse C, Sabbagh C, Marx S, Caus T, Henry M, et al. Biological scoring system for early prediction of acute bowel ischemia after cardiac surgery: the PALM score. Ann Intensive Care. 2018;8:46 pubmed publisher
    ..15, a Youden's index of 0.802, and a diagnostic odds ratio of 106.62. A biological scoring system based on PCT, ASAT, lactate, and myoglobin measurement allows the diagnosis of bowel ischemia after cardiac surgery with high accuracy...
  5. van Capelle C, van der Meijden J, van den Hout J, Jaeken J, Baethmann M, Voit T, et al. Childhood Pompe disease: clinical spectrum and genotype in 31 patients. Orphanet J Rare Dis. 2016;11:65 pubmed publisher
    ..as disproportional weakness of the neck flexors, unexplained fatigue, persistent diarrhea and unexplained high CK/ASAT/ALAT. Disease presentation appears to be different from adult patients...
  6. Calzadilla P, Signorelli S, Escaray F, Menéndez A, Monza J, Ruiz O, et al. Photosynthetic responses mediate the adaptation of two Lotus japonicus ecotypes to low temperature. Plant Sci. 2016;250:59-68 pubmed publisher
    ..Interestingly, D2 recovery was accompanied by improvements in photosynthetic parameters (Asat and Fv/Fm) and the NADPH/NADP(+) ratio...
  7. da Silva A, Reginato F, Guex C, Figueredo K, da C Araldi I, de Freitas R, et al. Acute and sub-chronic (28 days) oral toxicity evaluation of tincture Baccharis trimera (Less) Backer in male and female rodent animals. Regul Toxicol Pharmacol. 2016;74:170-7 pubmed publisher
    ..parameters, except for the hepatic enzymes alanine aminotransferase (ALAT) and aspartate aminotransferase (ASAT) that showed a reduction in both sexes. Moreover, the B...
  8. Athmouni K, Belhaj D, El Feki A, Ayadi H. Optimization, antioxidant properties and GC-MS analysis of Periploca angustifolia polysaccharides and chelation therapy on cadmium-induced toxicity in human HepG2 cells line and rat liver. Int J Biol Macromol. 2018;108:853-862 pubmed publisher
    ..decreased the content of MDA and protein damage in liver tissue, and enhanced liver function parameters (ALAT, ASAT and bilirubin), as well as the activities of hepatic antioxidant status (SOD, CAT, GPx and GSH)...
  9. Fan P, Miller A, Schilmiller A, Liu X, Ofner I, Jones A, et al. In vitro reconstruction and analysis of evolutionary variation of the tomato acylsucrose metabolic network. Proc Natl Acad Sci U S A. 2016;113:E239-48 pubmed publisher
    ..Comparative genomics and biochemical analysis of ASAT enzymes were combined with in vitro mutagenesis to identify amino acids that influence CoA ester substrate ..
  10. Fahrner R, Möller A, Press A, Kortgen A, Kiehntopf M, Rauchfuss F, et al. Short-term treatment with taurolidine is associated with liver injury. BMC Pharmacol Toxicol. 2017;18:61 pubmed publisher
    ..After 24 h a significant increase of serum GLDH and ASAT was observed in rats treated with high-dose taurolidine treatment...
  11. Carpenter K, Keidel T, Pihl M, Hughes N. Support for a photoprotective function of winter leaf reddening in nitrogen-deficient individuals of Lonicera japonica. Molecules. 2014;19:17810-28 pubmed publisher
    ..total chlorophyll, quantum yield efficiency, carboxylation efficiency, and photosynthesis at saturating irradiance (Asat). Light-response curves measured using ambient sunlight versus red-blue LED (i.e...
  12. Abd El Latif A, Sayed A, Soliman A, Fahmy S. Exploration of the therapeutic potential effect of Sepia officinalis in animal model of sepsis induced by cecal ligation and puncture. Injury. 2016;47:2709-2717 pubmed publisher
    ..CLP-induced liver and kidney toxicities showed by an increase in the ALAT, ASAT, γGT, ALP, creatinine, BUN and uric acid concentrations in serum...
  13. Kiss K, Brozik A, Kucsma N, Toth A, Gera M, Berry L, et al. Shifting the paradigm: the putative mitochondrial protein ABCB6 resides in the lysosomes of cells and in the plasma membrane of erythrocytes. PLoS ONE. 2012;7:e37378 pubmed publisher
    ..Taken together, our results challenge the current paradigm linking the expression and function of ABCB6 to mitochondria...
  14. Belhaj D, Athmouni K, Ahmed M, Aoiadni N, El Feki A, Zhou J, et al. Polysaccharides from Phormidium versicolor (NCC466) protecting HepG2 human hepatocellular carcinoma cells and rat liver tissues from cadmium toxicity: Evidence from in vitro and in vivo tests. Int J Biol Macromol. 2018;113:813-820 pubmed publisher
    ..05) reduced the level of ALAT, ASAT, biliburin, MDA, protein carbonyl and DNA damage, and markedly increased enzyme activities in liver tissues...
  15. Drake J, Macdonald C, Tjoelker M, Crous K, Gimeno T, Singh B, et al. Short-term carbon cycling responses of a mature eucalypt woodland to gradual stepwise enrichment of atmospheric CO2 concentration. Glob Chang Biol. 2016;22:380-90 pubmed publisher
    ..Light-saturated photosynthesis of canopy leaves (Asat ) also showed similar stimulation by elevated CO2 at +60 ppm as at +150 ppm CO2 ...
  16. Mupo A, Seiler M, Sathiaseelan V, Pance A, Yang Y, Agrawal A, et al. Hemopoietic-specific Sf3b1-K700E knock-in mice display the splicing defect seen in human MDS but develop anemia without ring sideroblasts. Leukemia. 2017;31:720-727 pubmed publisher
    ..Future studies should focus on understanding the basis of these similarities and differences as a means of deciphering the consequences of spliceosome gene mutations in MDS. ..
  17. Leischow S, Okamoto J, McIntosh S, Ossip D, Lando H. Network analysis of global tobacco control collaboration: data from the World Conference on Tobacco or Health (WCTOH). BMC Public Health. 2017;17:338 pubmed publisher
    ..to be growing, such as the African Tobacco Control Alliance (ATCA) and the Argentinian Association of Tabacology (ASAT)...
  18. van der Noll R, Smit W, Wymenga A, Boss D, Grob M, Huitema A, et al. Phase I and pharmacological trial of lapatinib in combination with gemcitabine in patients with advanced breast cancer. Invest New Drugs. 2015;33:1197-205 pubmed publisher
    ..Most common toxicities were fatigue (73%), nausea (70%), diarrhea (58%), increases in ALAT and ASAT (55 and 52%, respectively) and rash (46%)...
  19. El Hidan M, Touloun O, El Hiba O, Laadraoui J, Ferehan H, Boumezzough A. Peripheral and central effects of intracerebroventricular microinjection of Hottentotta gentili (Pallary, 1924) (Scorpiones, Buthidae) venom. Toxicon. 2016;111:22-30 pubmed publisher
    ..Concurrently, there was a significant rise in the serum enzymes levels of ASAT, ALAT, CPK and LDH...
  20. Zutz A, Gompf S, Schagger H, Tampe R. Mitochondrial ABC proteins in health and disease. Biochim Biophys Acta. 2009;1787:681-90 pubmed publisher
  21. Zhang W, Wang G, Liu X, Feng Z. Effects of elevated O3 exposure on seed yield, N concentration and photosynthesis of nine soybean cultivars (Glycine max (L.) Merr.) in Northeast China. Plant Sci. 2014;226:172-81 pubmed publisher
    ..Positive correlation between effects of E-O3 on leaf N content and effects on light saturated photosynthetic rate (Asat) indicated that gs and leaf N content at seed filling stage contributes to yield loss and decreased photosynthesis ..
  22. Dotto G, Pinto L, Hachicha M, Knani S. New physicochemical interpretations for the adsorption of food dyes on chitosan films using statistical physics treatment. Food Chem. 2015;171:1-7 pubmed publisher
    ..dye molecules per site (n), anchorage number (n'), receptor sites density (NM), adsorbed quantity at saturation (N asat), steric hindrance (τ), concentration at half saturation (c1/2) and molar adsorption energy (ΔE(a)) were ..
  23. Saito S, Iida A, Sekine A, Miura Y, Ogawa C, Kawauchi S, et al. Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population. J Hum Genet. 2002;47:38-50 pubmed
    ..These variants may contribute to investigations of possible correlations between genotypes and disease-susceptibility phenotypes or responsiveness to drug therapy...
  24. Li J, Cowan J. Glutathione-coordinated [2Fe-2S] cluster: a viable physiological substrate for mitochondrial ABCB7 transport. Chem Commun (Camb). 2015;51:2253-5 pubmed publisher
    ..cluster is demonstrated to be a viable and likely substrate for physiological iron-sulfur cluster transport by Atm1p, a mitochondrial ABC export protein...
  25. Uysal E, Paksoy Y, Koplay M, Nayman A, Gumus S. Effects of body mass index, mesenteric and abdominal subcutaneous adipose tissue on the spinopelvic parameters. Wien Klin Wochenschr. 2015;127:935-41 pubmed publisher
    ..was to investigate the effects of body mass index (BMI), thickness of the abdominal subcutaneous adipose tissue (ASAT), thickness of the mesenteric adipose tissue (MAT), weight and height on spinopelvic parameters...
  26. Jiao X, Kørup K, Andersen M, Petersen K, Prade T, Jeżowski S, et al. Low-temperature leaf photosynthesis of a Miscanthus germplasm collection correlates positively to shoot growth rate and specific leaf area. Ann Bot. 2016;117:1229-39 pubmed publisher
    ..A positive linear relationship was found between SLA and light-saturated photosynthesis (Asat) across genotypes, and also between shoot growth rate under cool field conditions and A1000 at 14 °C in a ..
  27. Opris R, Tatomir C, Olteanu D, Moldovan R, Moldovan B, David L, et al. The effect of Sambucus nigra L. extract and phytosinthesized gold nanoparticles on diabetic rats. Colloids Surf B Biointerfaces. 2017;150:192-200 pubmed publisher
    ..Serum glycemia, cholesterol, alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT) were also measured...
  28. Blasco J, Moya A, Millán Cubillo A, Vélez E, Capilla E, Pérez Sánchez J, et al. Growth-promoting effects of sustained swimming in fingerlings of gilthead sea bream (Sparus aurata L.). J Comp Physiol B. 2015;185:859-68 pubmed publisher
    ..composition [proximate and isotopic ((15)N/(13)C)] and metabolic key enzymes (COX, CS, LDH, HOAD, HK, ALAT, ASAT) of white muscle...
  29. McElwain J, Yiotis C, Lawson T. Using modern plant trait relationships between observed and theoretical maximum stomatal conductance and vein density to examine patterns of plant macroevolution. New Phytol. 2016;209:94-103 pubmed publisher
    ..vein density (Dv ) and physiological measurements including operational stomatal conductance (gop ), saturated (Asat ) and maximum (Amax ) assimilation rates were investigated for 18 extant taxa in order to improve understanding of ..
  30. Zhu Y, Zheng M, Song D, Ye L, Wang X. Global comparison of chromosome X genes of pulmonary telocytes with mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells, and lymphocytes. J Transl Med. 2015;13:318 pubmed publisher
  31. Gateva A, Assyov Y, Velikova T, Kamenov Z. Increased peroxiredoxin 4 levels in patients with prediabetes compared to normal glucose tolerance subjects. Clin Endocrinol (Oxf). 2016;85:551-5 pubmed publisher
    ..P = 0·038), waist circumference (r = 0·239; P = 0·044), creatinine (r = 0·264; P = 0·019), liver enzymes (ASAT - r = 0·289; P = 0·019 and ALAT - r = 0·305; P = 0·07) and white blood cells count (r = 0·317; P = 0·005)...
  32. Fahmy S, Amien A, Abd Elgleel F, Elaskalany S. Antihepatotoxic efficacy of Mangifera indica L. polysaccharides against cyclophosphamide in rats. Chem Biol Interact. 2016;244:113-20 pubmed publisher
    ..The MPS and/or silymarin significantly decreased the activities of serum ASAT and ALAT. However, MPS (1000 mg/kg) normalized their activities towards the normal levels recording 28.75 and 78...
  33. Yuan X, Calatayud V, Gao F, Fares S, Paoletti E, Tian Y, et al. Interaction of drought and ozone exposure on isoprene emission from extensively cultivated poplar. Plant Cell Environ. 2016;39:2276-87 pubmed publisher
    ..Consistent with light-saturated photosynthesis (Asat ), intercellular CO2 concentration (Ci ) and chlorophyll content, isoprene emission depended on drought, O3 , leaf ..
  34. Abdel Wahhab K, Daoud E, El Gendy A, Mourad H, Mannaa F, Saber M. Efficiencies of Low-Level Laser Therapy (LLLT) and Gabapentin in the Management of Peripheral Neuropathy: Diabetic Neuropathy. Appl Biochem Biotechnol. 2018;186:161-173 pubmed publisher
    ..Values of serum alanine aminotransferase (ALAT), aspartate aminotransferase (ASAT), urea, and creatinine increased significantly in the DPN and diabetic rats without peripheral neuropathy (PN) ..
  35. Fidai I, Wachnowsky C, Cowan J. Glutathione-complexed [2Fe-2S] clusters function in Fe-S cluster storage and trafficking. J Biol Inorg Chem. 2016;21:887-901 pubmed publisher
    ..physiologically relevant solution chemistry and is a viable substrate for iron-sulfur cluster transport by Atm1p exporter protein...
  36. Jensen A, Warren J, Hanson P, Childs J, Wullschleger S. Needle age and season influence photosynthetic temperature response and total annual carbon uptake in mature Picea mariana trees. Ann Bot. 2015;116:821-32 pubmed publisher
    ..Temperature responses of key photosynthetic parameters [i.e. light-saturated rate of CO2 assimilation (Asat), rate of Rubisco carboxylation (Vcmax) and electron transport rate (Jmax)] were dependent on season and generally ..
  37. Pellegrini L, Belcaro G, Dugall M, Corsi M, Luzzi R, Hosoi M. Supplementary management of functional, temporary alcoholic hepatic damage with Robuvit® (French oak wood extract). Minerva Gastroenterol Dietol. 2016;: pubmed
    ..05 at 12 weeks) faster and higher in the Robuvit® group. The decreasee in ALT-SGPT and AST-ASAT were significantly larger in the supplement group (P<0.05 at 6 and 12 weeks)...
  38. Jung C, Fuernau G, Eitel I, Desch S, Schuler G, Kelm M, et al. Incidence, laboratory detection and prognostic relevance of hypoxic hepatitis in cardiogenic shock. Clin Res Cardiol. 2017;106:341-349 pubmed publisher
    ..34%; p < 0.001). After multivariable adjustment aspartate-aminotransferase (ASAT) remained an independent predictor of 30-day mortality together with serum lactate and serum creatinine, while the ..
  39. Belcaro G, Gizzi G, Corsi M, Dugall M, Hu S, Pellegrini L, et al. Liverubin (standardized silymarin) in the supplementary management of functional, temporary hepatic damage. A pilot, registry, study. Minerva Med. 2014;105:17-25 pubmed
    ..05). The decrease of ALT-SGPT and AST-ASAT was more evident in the supplement group (P<0.05). Improvement in controls was more limited...
  40. Pérez Jiménez A, Cardenete G, Hidalgo M, García Alcázar A, Abellán E, Morales A. Metabolic adjustments of Dentex dentex to prolonged starvation and refeeding. Fish Physiol Biochem. 2012;38:1145-1157 pubmed publisher
    ..oxaloacetate required for the reaction catalized by CS activity would be supplied by aspartate aminotransferase (ASAT) activity whose activity was also enhanced...
  41. Bouhafs L, Moudilou E, Exbrayat J, Lahouel M, Idoui T. Protective effects of probiotic Lactobacillus plantarum BJ0021 on liver and kidney oxidative stress and apoptosis induced by endosulfan in pregnant rats. Ren Fail. 2015;37:1370-8 pubmed publisher
    ..induced a significant increase in total cholesterol, alanine-amino transferase (ALAT), aspartate-amino transferase (ASAT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), urea and creatinine in serum, while urinary urea ..
  42. Efferth T, Schöttler U, Krishna S, Schmiedek P, Wenz F, Giordano F. Hepatotoxicity by combination treatment of temozolomide, artesunate and Chinese herbs in a glioblastoma multiforme patient: case report review of the literature. Arch Toxicol. 2017;91:1833-1846 pubmed publisher
    ..Elevated liver enzymes were noted with peak values of 238 U/L (GPT/ALAT), 226 U/L (GOT/ASAT), and 347 U/L (?-GT), respectively...
  43. Kaluthota S, Pearce D, Evans L, Letts M, Whitham T, Rood S. Higher photosynthetic capacity from higher latitude: foliar characteristics and gas exchange of southern, central and northern populations of Populus angustifolia. Tree Physiol. 2015;35:936-48 pubmed publisher
    ..carotenoid and chlorophyll content, and these were associated with higher light-saturated net photosynthesis (Asat)...
  44. Martínez García M, Campos Salinas J, Cabello Donayre M, Pineda Molina E, Gálvez F, Orrego L, et al. LmABCB3, an atypical mitochondrial ABC transporter essential for Leishmania major virulence, acts in heme and cytosolic iron/sulfur clusters biogenesis. Parasit Vectors. 2016;9:7 pubmed publisher
    ..Hence, LmABCB3 could represent a novel target to combat leishmaniasis. ..
  45. Laloy J, Lozano O, Alpan L, Mejia J, Toussaint O, Masereel B, et al. Can TiC nanoparticles produce toxicity in oral administration to rats?. Toxicol Rep. 2014;1:172-187 pubmed publisher
    ..In the acute administration, alkaline phosphatases increased (5, 300 and 1000 mg kg-1), ASAT increased (1000 mg kg-1) and bile salts decreased (0.5 mg kg-1)...
  46. Qi W, Li J, Cowan J. A structural model for glutathione-complexed iron-sulfur cluster as a substrate for ABCB7-type transporters. Chem Commun (Camb). 2014;50:3795-8 pubmed publisher
    ..A possible substrate-binding site is identified on a new structural model for the active transporter. ..
  47. Sato K, Torimoto Y, Hosoki T, Ikuta K, Takahashi H, Yamamoto M, et al. Loss of ABCB7 gene: pathogenesis of mitochondrial iron accumulation in erythroblasts in refractory anemia with ringed sideroblast with isodicentric (X)(q13). Int J Hematol. 2011;93:311-318 pubmed publisher
    ..These findings suggest that loss of the ABCB7 gene may be a pathogenetic factor underlying mitochondrial iron accumulation in RARS patients with idicXq13. ..
  48. Lerebours A, To V, Bourdineaud J. Danio rerio ABC transporter genes abcb3 and abcb7 play a protecting role against metal contamination. J Appl Toxicol. 2016;36:1551-1557 pubmed publisher
    ..5 and 2-times lower than in the control. This work provides new data on the function of zebrafish ABCB3 and ABCB7 transporters and highlights their significance in metal detoxification. Copyright © 2016 John Wiley & Sons, Ltd. ..
  49. Bernard D, Cheng Y, Zhao Y, Balk J. An allelic mutant series of ATM3 reveals its key role in the biogenesis of cytosolic iron-sulfur proteins in Arabidopsis. Plant Physiol. 2009;151:590-602 pubmed publisher
    ..arginine-612 is replaced by a lysine residue, the negative effect of which could be mimicked in the yeast Atm1p ortholog...
  50. Pondarre C, Campagna D, Antiochos B, Sikorski L, Mulhern H, Fleming M. Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis. Blood. 2007;109:3567-9 pubmed
    ..Here, we show that Abcb7 is essential for hematopoiesis and formally demonstrate that XLSA/A is due to partial loss of function mutations in Abcb7 that directly or indirectly inhibit heme biosynthesis...
  51. Iwaki T, Fujita Y, Tanaka N, Giga Hama Y, Takegawa K. Mitochondrial ABC transporter Atm1p is required for protection against oxidative stress and vacuolar functions in Schizosaccharomyces pombe. Biosci Biotechnol Biochem. 2005;69:2109-16 pubmed
    ..Growth of the atm1 mutant was inhibited in the presence of oxidizing agents, and S. cerevisiae Atm1p was found to complement this growth defect...
  52. Lill R, Dutkiewicz R, Freibert S, Heidenreich T, Mascarenhas J, Netz D, et al. The role of mitochondria and the CIA machinery in the maturation of cytosolic and nuclear iron-sulfur proteins. Eur J Cell Biol. 2015;94:280-91 pubmed publisher
  53. Savary S, Allikmets R, Denizot F, Luciani M, Mattei M, Dean M, et al. Isolation and chromosomal mapping of a novel ATP-binding cassette transporter conserved in mouse and human. Genomics. 1997;41:275-8 pubmed
    ..identification and genomic mapping of a novel member of the family of the ATP-binding cassette (ABC) transporters, ABC7, conserved in mouse and in humans...
  54. Taketani S, Kakimoto K, Ueta H, Masaki R, Furukawa T. Involvement of ABC7 in the biosynthesis of heme in erythroid cells: interaction of ABC7 with ferrochelatase. Blood. 2003;101:3274-80 pubmed
    A mitochondrial half-type ATP-binding cassette (ABC) protein, ABC7, plays a role in iron homeostasis in mitochondria, and defects in human ABC7 were shown to be responsible for the inherited disease X-linked sideroblastic anemia/ataxia...
  55. Ueta R, Fujiwara N, Iwai K, Yamaguchi Iwai Y. Iron-induced dissociation of the Aft1p transcriptional regulator from target gene promoters is an initial event in iron-dependent gene suppression. Mol Cell Biol. 2012;32:4998-5008 pubmed publisher
    ..The mitochondrial transporter Atm1p, which has been implicated in the export of iron-sulfur clusters and related molecules, is required not only for ..
  56. Gonzalez Cabo P, Bolinches Amorós A, Cabello J, Ros S, Moreno S, Baylis H, et al. Disruption of the ATP-binding cassette B7 (ABTM-1/ABCB7) induces oxidative stress and premature cell death in Caenorhabditis elegans. J Biol Chem. 2011;286:21304-14 pubmed publisher
    ..Therefore, ablation of abtm-1 in C. elegans provides a model in which to investigate the mechanism underlying XLSA/A...
  57. Bailey C, Tully M, Pampaka M, Cooke J. Rasch analysis of the Antimicrobial Self-Assessment Toolkit for National Health Service (NHS) Trusts (ASAT v17). J Antimicrob Chemother. 2017;72:604-613 pubmed publisher
    The Antimicrobial Self-Assessment Toolkit for National Health Service (NHS) Trusts (ASAT) was developed to evaluate hospital-based antimicrobial stewardship programmes...
  58. Petit M, Mine L, Pascreau T, Brouzes C, Majoux S, Borgel D, et al. Preanalytical influence of pneumatic tube delivery system on results of routine biochemistry and haematology analysis. Ann Biol Clin (Paris). 2017;: pubmed publisher
    ..following analysis: ionized calcium, sodium, potassium, lactate deshydrogenase (LDH), aspartate aminotransferase (ASAT), arterial blood gas, complete blood count and coagulation test as prothrombin time, activated partial ..
  59. Allikmets R, Gerrard B, Hutchinson A, Dean M. Characterization of the human ABC superfamily: isolation and mapping of 21 new genes using the expressed sequence tags database. Hum Mol Genet. 1996;5:1649-55 pubmed
  60. Corral Debrinski M, Blugeon C, Jacq C. In yeast, the 3' untranslated region or the presequence of ATM1 is required for the exclusive localization of its mRNA to the vicinity of mitochondria. Mol Cell Biol. 2000;20:7881-92 pubmed
    ..Some mRNAs exclusively localize to mitochondrion-bound polysomes, such as the ones coding for Atm1p, Cox10p, Tim44p, Atp2p, and Cot1p...
  61. Srinivasan V, Pierik A, Lill R. Crystal structures of nucleotide-free and glutathione-bound mitochondrial ABC transporter Atm1. Science. 2014;343:1137-40 pubmed publisher
    ..The resulting protein stabilization may be a common structural feature of all ABC exporters. ..
  62. Nikpour M, Scharenberg C, Liu A, Conte S, Karimi M, Mortera Blanco T, et al. The transporter ABCB7 is a mediator of the phenotype of acquired refractory anemia with ring sideroblasts. Leukemia. 2013;27:889-896 pubmed publisher
    ..Our findings support that ABCB7 is implicated in the phenotype of acquired RARS and suggest a relation between SF3B1 mutations and ABCB7 downregulation. ..
  63. Krishnamurthy P, Du G, Fukuda Y, Sun D, Sampath J, Mercer K, et al. Identification of a mammalian mitochondrial porphyrin transporter. Nature. 2006;443:586-9 pubmed
    ..This process is blocked when the Abcb6 gene is silenced. Our results challenge previous assumptions about the intracellular movement of porphyrins and the factors controlling haem biosynthesis...
  64. Miao L, Huang C, Hou J, Qian M. Association study of ABCB1 and CYP3A5 gene polymorphisms with sirolimus trough concentration and dose requirements in Chinese renal transplant recipients. Biopharm Drug Dispos. 2008;29:1-5 pubmed
    ..In patients with SRL-based therapy, genotyping of the CYP3A5 genes may help to optimize the SRL management in renal transplant recipients. ..
  65. Ye H, Rouault T. Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease. Biochemistry. 2010;49:4945-56 pubmed publisher
  66. Schaedler T, Faust B, Shintre C, Carpenter E, Srinivasan V, van Veen H, et al. Structures and functions of mitochondrial ABC transporters. Biochem Soc Trans. 2015;43:943-51 pubmed publisher
    ..Combined with in vitro and in vivo studies, progress is being made to find the physiological substrates of the different mitochondrial ABC transporters. ..
  67. Miao R, Kim H, Koppolu U, Ellis E, Scott R, Lindahl P. Biophysical characterization of the iron in mitochondria from Atm1p-depleted Saccharomyces cerevisiae. Biochemistry. 2009;48:9556-68 pubmed publisher
    b>Atm1p is an ABC transporter localized in the mitochondrial inner membrane; it functions to export an unknown species into the cytosol and is involved in cellular iron metabolism...
  68. Csere P, Lill R, Kispal G. Identification of a human mitochondrial ABC transporter, the functional orthologue of yeast Atm1p. FEBS Lett. 1998;441:266-70 pubmed
    ..and displays high sequence similarity to the mouse ABC7 protein and to the mitochondrial ABC transporter Atm1p of Saccharomyces cerevisiae...
  69. Kispal G, Csere P, Guiard B, Lill R. The ABC transporter Atm1p is required for mitochondrial iron homeostasis. FEBS Lett. 1997;418:346-50 pubmed
    The function of the ABC transporter Atm1p located in the mitochondrial inner membrane is not yet known. To study its cellular role, we analyzed a mutant in which ATM1 was disrupted...
  70. Chloupkova M, LeBard L, Koeller D. MDL1 is a high copy suppressor of ATM1: evidence for a role in resistance to oxidative stress. J Mol Biol. 2003;331:155-65 pubmed
    ..b>Atm1p is an ATP-binding cassette (ABC) transporter localized to the mitochondrial inner membrane...
  71. Maguire A, Hellier K, Hammans S, May A. X-linked cerebellar ataxia and sideroblastic anaemia associated with a missense mutation in the ABC7 gene predicting V411L. Br J Haematol. 2001;115:910-7 pubmed
    ..protoporphyrin led to a search using a combination of DNA and cDNA analysis for the presence of mutations in the ABC7 gene. ABC7 encodes a mitochondrial half-type ATP Binding Cassette transporter involved in iron homeostasis...
  72. Inokura K, Fujiwara T, Saito K, Iino T, Hatta S, Okitsu Y, et al. Impact of TET2 deficiency on iron metabolism in erythroblasts. Exp Hematol. 2017;49:56-67.e5 pubmed publisher
    ..Furthermore, Tet2 knockdown in erythroblasts resulted in decreased heme concentration and accumulation of FTMT. Therefore, TET2 plays a role in the iron and heme metabolism in erythroblasts. ..
  73. Lill R, Kispal G. Mitochondrial ABC transporters. Res Microbiol. 2001;152:331-40 pubmed
    ..fall into two major classes that, in the yeast Saccharomyces cerevisiae, are represented by the half-transporter Atm1p and the two closely homologous proteins Mdl1p and Mdl2p...
  74. D Hooghe M, Selleslag D, Mortier G, Van Coster R, Vermeersch P, Billiet J, et al. X-linked sideroblastic anemia and ataxia: a new family with identification of a fourth ABCB7 gene mutation. Eur J Paediatr Neurol. 2012;16:730-5 pubmed publisher
    ..Until now only three families have been reported, each with a distinct missense mutation in this gene. We describe a fourth family with XLSA-A and a novel mutation in the ABCB7 gene...
  75. Mitsuhashi N, Miki T, Senbongi H, Yokoi N, Yano H, Miyazaki M, et al. MTABC3, a novel mitochondrial ATP-binding cassette protein involved in iron homeostasis. J Biol Chem. 2000;275:17536-40 pubmed
    b>Atm1p, a mitochondrial half-type ATP-binding cassette (ABC) protein in Saccharomyces cerevisiae, transports a precursor of the iron-sulfur (Fe/S) cluster from mitochondria to the cytosol...
  76. Liesa M, Qiu W, Shirihai O. Mitochondrial ABC transporters function: the role of ABCB10 (ABC-me) as a novel player in cellular handling of reactive oxygen species. Biochim Biophys Acta. 2012;1823:1945-57 pubmed publisher
    ..We discuss ABCB10 as a potential therapeutic target for diseases in which increased mitochondrial ROS production and oxidative stress play a major role...
  77. Chloupkova M, Reaves S, LeBard L, Koeller D. The mitochondrial ABC transporter Atm1p functions as a homodimer. FEBS Lett. 2004;569:65-9 pubmed
    ..In this study, we have evaluated the role of conserved sequence elements in Atm1p in its function and dimerization in vivo...
  78. Boultwood J, Pellagatti A, Nikpour M, Pushkaran B, Fidler C, Cattan H, et al. The role of the iron transporter ABCB7 in refractory anemia with ring sideroblasts. PLoS ONE. 2008;3:e1970 pubmed publisher
    ..These data provide an important link between inherited and acquired forms of sideroblastic anemia and indicate that ABCB7 is a strong candidate gene for RARS...
  79. Leighton J, Schatz G. An ABC transporter in the mitochondrial inner membrane is required for normal growth of yeast. EMBO J. 1995;14:188-95 pubmed
    ..This gene, termed ATM1, encodes a putative 'half-transporter' of 694 amino acids. Atm1p is synthesized with an N-terminal mitochondrial matrix-targeting signal and is located in the mitochondrial inner ..
  80. Pondarre C, Antiochos B, Campagna D, Clarke S, Greer E, Deck K, et al. The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum Mol Genet. 2006;15:953-64 pubmed
    ..Abcb7, which is mutated in X-linked sideroblastic anemia with ataxia in humans, is a functional ortholog of yeast Atm1p and is predicted to export a mitochondrially derived metabolite required for cytosolic Fe-S cluster assembly...
  81. Kuhnke G, Neumann K, Muhlenhoff U, Lill R. Stimulation of the ATPase activity of the yeast mitochondrial ABC transporter Atm1p by thiol compounds. Mol Membr Biol. 2006;23:173-84 pubmed
    The ATP binding cassette (ABC) transporter Atm1p of the mitochondrial inner membrane performs crucial roles in both the biogenesis of cytosolic/nuclear iron-sulfur proteins and cellular iron homeostasis...
  82. Chen C, Cowan J. Characterization of Saccharomyces cerevisiae Atm1p: functional studies of an ABC7 type transporter. Biochim Biophys Acta. 2006;1760:1857-65 pubmed
    Saccharomyces cerevisiae Atm1p has been cloned, over-expressed and purified from a yeast expression system. The sequence includes both the soluble ATPase and transmembrane-spanning domains...
  83. El Gendy M, Abdel Wahhab K, Mannaa F, Farghaly A, El Bondkly A. Carcinogenic Activities and Sperm Abnormalities of Methicillin Resistance Staphylococcus aureus and Inhibition of Their Virulence Potentials by Ayamycin. Appl Biochem Biotechnol. 2017;183:833-852 pubmed publisher
    ..01) increases in the activities of the serum alanine aminotransferase (ALAT) and aspartate aminotransferase (ASAT) enzymes...
  84. Mikolay A, Nies D. The ABC-transporter AtmA is involved in nickel and cobalt resistance of Cupriavidus metallidurans strain CH34. Antonie Van Leeuwenhoek. 2009;96:183-91 pubmed publisher
    Cupriavidus metallidurans CH34 genome contains an ortholog of Atm1p named AtmA (Rmet_0391, YP_582546)...
  85. Bedekovics T, Li H, Gajdos G, Isaya G. Leucine biosynthesis regulates cytoplasmic iron-sulfur enzyme biogenesis in an Atm1p-independent manner. J Biol Chem. 2011;286:40878-88 pubmed publisher
    ..precursors exported from the mitochondria via an ATP binding cassette (ABC) transporter conserved from yeast (Atm1p) to humans (ABCB7)...
  86. Dolatshad H, Pellagatti A, Liberante F, Llorian M, Repapi E, Steeples V, et al. Cryptic splicing events in the iron transporter ABCB7 and other key target genes in SF3B1-mutant myelodysplastic syndromes. Leukemia. 2016;30:2322-2331 pubmed publisher
  87. Protasova M, Grigorenko A, Tyazhelova T, Andreeva T, Reshetov D, Gusev F, et al. Whole-genome sequencing identifies a novel ABCB7 gene mutation for X-linked congenital cerebellar ataxia in a large family of Mongolian ancestry. Eur J Hum Genet. 2016;24:550-5 pubmed publisher
    ..Our finding links cerebellar pathology to the genetic defect in ABCB7 and ATP7A structural variant inherited as X-linked trait, and further reveals the genetic heterogeneity of X-linked cerebellar disorders. ..