ABAT

Summary

Gene Symbol: ABAT
Description: 4-aminobutyrate aminotransferase
Alias: GABA-AT, GABAT, NPD009, 4-aminobutyrate aminotransferase, mitochondrial, (S)-3-amino-2-methylpropionate transaminase, 4-aminobutyrate transaminase, GABA aminotransferase, GABA transaminase, GABA transferase, gamma-amino-N-butyrate transaminase
Species: human
Products:     ABAT

Top Publications

  1. Jaeken J, Casaer P, De Cock P, Corbeel L, Eeckels R, Eggermont E, et al. Gamma-aminobutyric acid-transaminase deficiency: a newly recognized inborn error of neurotransmitter metabolism. Neuropediatrics. 1984;15:165-9 pubmed
    ..Postmortem examination of his brain showed leukodystrophy of the type seen in amino acidopathies such as phenylketonuria. This appears to be the first report of gamma-aminobutyric acid-transaminase deficiency. ..
  2. Medina Kauwe L, Tobin A, De Meirleir L, Jaeken J, Jakobs C, Nyhan W, et al. 4-Aminobutyrate aminotransferase (GABA-transaminase) deficiency. J Inherit Metab Dis. 1999;22:414-27 pubmed
    ..Genomic Southern analysis revealed that the second proband most likely harbours a deletion in the 3' region of the GABA-T gene. ..
  3. Jia P, Wang L, Meltzer H, Zhao Z. Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data. Schizophr Res. 2010;122:38-42 pubmed publisher
    ..The genes involved in these pathways had not been detected by single marker analysis, suggesting this approach may complement the original analysis of GWAS dataset. ..
  4. Li C, Niu M, Wang R, Zhou X, Dong B, Qi S, et al. The modulatory properties of Si Jun Zi Tang enhancing anticancer of gefitinib by an integrating approach. Biomed Pharmacother. 2019;111:1132-1140 pubmed publisher
    ..Our results indicated that SJZ enhanced the anti-lung cancer effects of gefitinib via the key targets ABCG2, ABCC1, ABAT, GSR, CYP1A2, ALOX5, CYP3A4, PLA2G1B and PLA2G2A and the key metabolites 2-oxoglutarate, taurocholic acid, oxidized ..
  5. Rasmusson A, King M, Valovski I, Gregor K, Scioli Salter E, Pineles S, et al. Relationships between cerebrospinal fluid GABAergic neurosteroid levels and symptom severity in men with PTSD. Psychoneuroendocrinology. 2019;102:95-104 pubmed publisher
    ..Consideration of sex, PTSD severity, and function of 5α-reductase and 3α-HSD thus may enable better targeting of neurosteroid-based PTSD treatments. ..
  6. Kutyrev I, Franke F, Kurtz J, Scharsack J. In vitro effects of the neuroactive substances serotonin and γ-aminobutyric acid on leucocytes from sticklebacks (Gasterosteus aculeatus). Fish Shellfish Immunol. 2019;87:286-296 pubmed publisher
    ..The granulocyte-to-lymphocyte ratios generally increased upon exposure to GABA at all concentrations. All concentrations of GABA alone elevated the ROS production of HKLs compared to controls...
  7. Besse A, Wu P, Bruni F, Donti T, Graham B, Craigen W, et al. The GABA transaminase, ABAT, is essential for mitochondrial nucleoside metabolism. Cell Metab. 2015;21:417-27 pubmed publisher
    b>ABAT is a key enzyme responsible for catabolism of principal inhibitory neurotransmitter γ-aminobutyric acid (GABA)...
  8. Rodríguez Lozada J, Tovar Gudiño E, Guevara Salazar J, Razo Hernández R, Santiago A, Pastor N, et al. QSAR and Molecular Docking Studies of the Inhibitory Activity of Novel Heterocyclic GABA Analogues over GABA-AT. Molecules. 2018;23: pubmed publisher
  9. Neumann E, Ralvenius W, Acuña M, Rudolph U, Zeilhofer H. TP003 is a non-selective benzodiazepine site agonist that induces anxiolysis via α2GABAA receptors. Neuropharmacology. 2018;143:71-78 pubmed publisher
    Benzodiazepines (BDZ), which potentiate the action of GABA at four subtypes of GABAA receptors (α1, α2, α3, and α5GABAARs), are highly effective against anxiety disorders, but also cause severe side effects ..

More Information

Publications117 found, 100 shown here

  1. Hashimotodani Y, Karube F, Yanagawa Y, Fujiyama F, Kano M. Supramammillary Nucleus Afferents to the Dentate Gyrus Co-release Glutamate and GABA and Potentiate Granule Cell Output. Cell Rep. 2018;25:2704-2715.e4 pubmed publisher
    ..Our results indicate that the SuM influences DG information processing by modulating GC outputs. ..
  2. Sahinovic M, Struys M, Absalom A. Clinical Pharmacokinetics and Pharmacodynamics of Propofol. Clin Pharmacokinet. 2018;57:1539-1558 pubmed publisher
    ..In this review, we provide an overview of the PK and PD of propofol in order to refresh readers' knowledge of its clinical applications, while discussing the main avenues of research where significant recent advances have been made. ..
  3. Li W, Wu X, Yuan X, Zhou W, Wu T. Rapid evaluation of γ-aminobutyric acid in foodstuffs by direct real-time mass spectrometry. Food Chem. 2019;277:617-623 pubmed publisher
    ..Samples of germinated barley and fermented beans containing GABA at different levels were used, and the results were compared with those obtained by ultrahigh-performance liquid ..
  4. Kowalczyk P, Kulig K. GABA system as a target for new drugs. Curr Med Chem. 2014;21:3294-309 pubmed
    ..affecting the GABA receptors, the plasma-membrane GABA transporters (GATs) and catabolic enzyme GABA-transaminase (GABAT)...
  5. Shao X, Yang W, Shao X, Qiu C, Wang X, Wang Y. The role of active brown adipose tissue (aBAT) in lipid metabolism in healthy Chinese adults. Lipids Health Dis. 2016;15:138 pubmed publisher
    ..Studies have shown that the activity of aBAT is related to the lipid metabolism...
  6. Nutt D, Wilson S, Lingford Hughes A, Myers J, Papadopoulos A, Muthukumaraswamy S. Differences between magnetoencephalographic (MEG) spectral profiles of drugs acting on GABA at synaptic and extrasynaptic sites: a study in healthy volunteers. Neuropharmacology. 2015;88:155-63 pubmed publisher
    ..Tiagabine theoretically can affect both types of receptor; from these MEG results it is likely that the latter is the more prominent effect here. ..
  7. Kanani A, Zaini F, Kordbacheh P, Falahati M, Rezaie S, Daie R, et al. Identification of Azole Resistance Markers in Clinical Isolates of Candida tropicalis Using cDNA-AFLP Method. J Clin Lab Anal. 2016;30:266-72 pubmed publisher
    ..adenosylmethionine-8-amino-7-oxononanoate aminotransferase (DAPA AT), and 4-aminobutyrate aminotransferase (ABAT)-belonging to pyridoxal phosphate (PLP) dependent enzymes and acting in an important physiological role in many ..
  8. Okuda K, Ito T, Goto M, Takenaka T, Hemmi H, Yoshimura T. Domain characterization of Bacillus subtilis GabR, a pyridoxal 5'-phosphate-dependent transcriptional regulator. J Biochem. 2015;158:225-34 pubmed publisher
    ..the presence of γ-aminobutyrate (GABA), GabR activates the transcription of gabT and gabD, which encode GABA aminotransferase and succinate semialdehyde dehydrogenase, respectively...
  9. Sahu M, Siddiqui N, Sharma V, Wakode S. 5,6-Dihydropyrimidine-1(2H)-carbothioamides: Synthesis, in vitro GABA-AT screening, anticonvulsant activity and molecular modelling study. Bioorg Chem. 2018;77:56-67 pubmed publisher
    ..4 mg/kg (TD50) with no sign of neurotoxicity. Furthermore, in vitro GABA-AT enzyme activity assay of 4g showed inhibitory potency (IC50) of 12.23 μM. The docking study also favored the animal studies. ..
  10. Si Y, Wen H, Li Y, He F, Li J, Li S, et al. Liver transcriptome analysis reveals extensive transcriptional plasticity during acclimation to low salinity in Cynoglossus semilaevis. BMC Genomics. 2018;19:464 pubmed publisher
    ..Genes acat2, fdps, hmgcr, hmgcs1, mvk, pmvk, ebp, lss, dhcr7, and dhcr24 were up-regulated and abat, ddc, acy1 were down-regulated in metabolic pathways...
  11. Budczies J, Denkert C. Tissue-Based Metabolomics to Analyze the Breast Cancer Metabolome. Recent Results Cancer Res. 2016;207:157-75 pubmed publisher
    ..New metabolism-related biomarkers were discovered including the 4-aminobutyrate aminotransferase ABAT, where low mRNA expression led to an accumulation of beta-alanine and shortened relapse-free survival...
  12. Moser P, Hingerl L, Strasser B, Považan M, Hangel G, Andronesi O, et al. Whole-slice mapping of GABA and GABA+ at 7T via adiabatic MEGA-editing, real-time instability correction, and concentric circle readout. Neuroimage. 2019;184:475-489 pubmed publisher
    ..Robust and accurate 2D mapping has been shown for the neurotransmitters GABA and Glx. ..
  13. Tassano E, Alpigiani M, Calcagno A, Salvati P, De Miglio L, Fiorio P, et al. Clinical and molecular delineation of a 16p13.2p13.13 microduplication. Eur J Med Genet. 2015;58:194-8 pubmed publisher
    ..2p13.13 were previously described. The duplicated region contains 21 OMIM genes and, six of them (RBFOX1, TMEM114, ABAT, PMM2, GRIN2A and, LITAF) were found to be associated with known diseases...
  14. Naffaa M, Absalom N, Solomon V, Chebib M, Hibbs D, Hanrahan J. Investigating the Role of Loop C Hydrophilic Residue 'T244' in the Binding Site of ρ1 GABAC Receptors via Site Mutation and Partial Agonism. PLoS ONE. 2016;11:e0156618 pubmed publisher
    ..1 T244A and ρ1 T244C mutant receptors have minimal sensitivity to GABA at high mM concentrations, whereas, the ρ1 WT partial agonists, β-alanine and MTSEA demonstrate more efficacy and ..
  15. Amakhin D, Soboleva E, Zaitsev A. Cephalosporin antibiotics are weak blockers of GABAa receptor-mediated synaptic transmission in rat brain slices. Biochem Biophys Res Commun. 2018;499:868-874 pubmed publisher
    ..The experiments involving the fast application of GABA at various concentrations to isolated neurons suggests that cefepime blocks receptors competitively, while ..
  16. Basil P, Li Q, Gui H, Hui T, Ling V, Wong C, et al. Prenatal immune activation alters the adult neural epigenome but can be partly stabilised by a n-3 polyunsaturated fatty acid diet. Transl Psychiatry. 2018;8:125 pubmed publisher
    ..of two of the 'top five' genes identified from an integrated analysis of DMRs, DHSs and MECP2 binding sites, namely Abat (t = 2.46, p < 0.02) and Gnas9 (t = 2.96, p < 0...
  17. Wang Y, Summers T, Peterson W, Miiller E, Burrell B. Differential effects of GABA in modulating nociceptive vs. non-nociceptive synapses. Neuroscience. 2015;298:397-409 pubmed publisher
    ..nervous system of the medicinal leech was used to study the functional significance of opposing effects of GABA at the synaptic circuit level...
  18. Piplani S, Verma P, Kumar A. Neuroinformatics analyses reveal GABAt and SSADH as major proteins involved in anticonvulsant activity of valproic acid. Biomed Pharmacother. 2016;81:402-10 pubmed publisher
    ..of VPA and corresponding natural ligands of four major enzymes involved in neurotransmissions, namely-GABA transaminase (GABAt), ?-keto glutarate dehydrogenase (?-KGDH), Succinate Semialdehyde dehydrogenase (SSADH) and Glutamate ..
  19. Mathew B, Ahsan M. Molecular recognisation of 3a, 4-dihydro-3-H-indeno [1, 2-C] pyrazole-2- carboxamide/carbothioamide anticonvulsant analogues towards GABA-aminotransferase- an in silico approach. Cent Nerv Syst Agents Med Chem. 2014;14:39-42 pubmed
    ..In this series, 4b, 4c, 4i, 4f and 4a showed significant binding free energy of -9.64, -9.31, -9.01, -8.99 and -8.29 with predicted inhibitory constant values of 0.086, 0.149, 0.237, 0.257 and 0.831 µM, respectively. ..
  20. Kirkovski M, Suo C, Enticott P, Yucel M, Fitzgerald P. Short communication: Sex-linked differences in gamma-aminobutyric acid (GABA) are related to social functioning in autism spectrum disorder. Psychiatry Res Neuroimaging. 2018;274:19-22 pubmed publisher
    ..b>GABA at the right superior temporal sulcus (STS) is reported for 12 ASD and 14 NT participants...
  21. Wang H, Morales M. Pedunculopontine and laterodorsal tegmental nuclei contain distinct populations of cholinergic, glutamatergic and GABAergic neurons in the rat. Eur J Neurosci. 2009;29:340-58 pubmed publisher
    ..transport of glutamate or for the synthesis of GABA, co-release of acetylcholine with either glutamate or GABA is unlikely to be a major factor in the interactions between acetylcholine, glutamate and GABA at the postsynaptic site.
  22. Finn D, Beadles Bohling A, Beckley E, Ford M, Gililland K, Gorin Meyer R, et al. A new look at the 5alpha-reductase inhibitor finasteride. CNS Drug Rev. 2006;12:53-76 pubmed
    ..Consistent with their ability to enhance the action of GABA at GABA(A) receptors, these steroid derivatives (termed neuroactive steroids) possess anticonvulsant, antidepressant ..
  23. Ali A. CB1 modulation of temporally distinct synaptic facilitation among local circuit interneurons mediated by N-type calcium channels in CA1. J Neurophysiol. 2011;105:1051-62 pubmed publisher
    ..Release of GABA at facilitating synapses was solely mediated via N-type presynaptic calcium channels, whereas depressing synapses ..
  24. Torres Torrelo J, Torres B, Carrascal L. Modulation of the input-output function by GABAA receptor-mediated currents in rat oculomotor nucleus motoneurons. J Physiol. 2014;592:5047-64 pubmed publisher
    ..Phasic inhibition mediated by γ-amino butyric acid (GABA) occurs when a high concentration of GABA at the synaptic cleft activates postsynaptic GABAA receptors, allowing neuronal information transfer...
  25. Guan X, Shi W, Zha S, Rong J, Su W, Liu G. Neurotoxic impact of acute TiO2 nanoparticle exposure on a benthic marine bivalve mollusk, Tegillarca granosa. Aquat Toxicol. 2018;200:241-246 pubmed publisher
    ..In addition, the expression of genes encoding modulatory enzymes (AChE, GABAT, and MAO) and receptors (mAChR3, GABAD, and DRD3) for the neurotransmitters tested were all significantly down-..
  26. Jiang Y, Xiao Y, Zhang X, Shu Y. Activation of axon initial segmental GABAA receptors inhibits action potential generation in neocortical GABAergic interneurons. Neuropharmacology. 2018;138:97-105 pubmed publisher
    ..Local application of GABA at the perisomatic axonal regions could evoke picrotoxin-sensitive currents with a reversal potential near the Cl<..
  27. Prescot A, Prisciandaro J, Miller S, Ingenito G, Kondo D, Renshaw P. Two-Dimensional Proton Magnetic Resonance Spectroscopy versus J-Editing for GABA Quantification in Human Brain: Insights from a GABA-Aminotransferase Inhibitor Study. Sci Rep. 2018;8:13200 pubmed publisher
    ..The data presented are particularly encouraging considering recent 2D 1H MRS methodological advances are continuing to improve temporal resolution and spatial coverage for achieving whole-brain, multi-metabolite mapping. ..
  28. Yang J, Johnson C, Shen J. Detection of reduced GABA synthesis following inhibition of GABA transaminase using in vivo magnetic resonance signal of [13C]GABA C1. J Neurosci Methods. 2009;182:236-43 pubmed publisher
    ..This slow labeling of GABA at elevated GABA concentration was attributed to the relatively small intercompartmental GABA-glutamine cycling flux ..
  29. Xu W, Tse Y, Dobie F, Baudry M, Craig A, Wong T, et al. Simultaneous monitoring of presynaptic transmitter release and postsynaptic receptor trafficking reveals an enhancement of presynaptic activity in metabotropic glutamate receptor-mediated long-term depression. J Neurosci. 2013;33:5867-5877 pubmed publisher
    ..method allowed us for the first time to selectively quantify the spontaneous or evoked release of glutamate or GABA at their respective synapses...
  30. Farb D, Ratner M. Targeting the modulation of neural circuitry for the treatment of anxiety disorders. Pharmacol Rev. 2014;66:1002-32 pubmed publisher
    ..These agents reduce anxiety rapidly by allosterically enhancing the postsynaptic actions of GABA at inhibitory type A GABA receptors but side effects limit their use in chronic anxiety disorders...
  31. Amatrudo J, Olson J, Agarwal H, Ellis Davies G. Caged compounds for multichromic optical interrogation of neural systems. Eur J Neurosci. 2015;41:5-16 pubmed publisher
    ..We also show that two-photon uncaging of DEAC450-Glu and CDNI-GABA at 900 and 720 nm, respectively, can be used to fire and block action potentials...
  32. Romei C, Sabolla C, Raiteri L. High-affinity GABA uptake by neuronal GAT1 transporters provokes release of [(3)H]GABA by homoexchange and through GAT1-independent Ca(2+)-mediated mechanisms. Neuropharmacology. 2015;88:164-70 pubmed publisher
    ..The significance of the novel function of the GABA high-affinity uptake here identified deserves further multidisciplinary investigation. ..
  33. Xie M, Chen H, Nie S, Yin J, Xie M. Gamma-Aminobutyric Acid Increases the Production of Short-Chain Fatty Acids and Decreases pH Values in Mouse Colon. Molecules. 2017;22: pubmed publisher
    ..The female Kunming mice were given GABA at doses of 5, 10, 20 and 40 mg/kg/d for 14 days...
  34. ENOCH M, Zhou Z, Kimura M, Mash D, Yuan Q, Goldman D. GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats. PLoS ONE. 2012;7:e29369 pubmed publisher
    ..There were also expression changes specific to cocaine addicts (GAD1, GAD2), alcoholics (GABRA2) and P rats (ABAT, GABRG3)...
  35. Pham V, Somasundaram S, Lee S, Park S, Hong S. Engineering the intracellular metabolism of Escherichia coli to produce gamma-aminobutyric acid by co-localization of GABA shunt enzymes. Biotechnol Lett. 2016;38:321-7 pubmed publisher
    ..produce GABA from glucose by the co-localization of enzymes succinate semialdehyde dehydrogenase (GadD), GABA aminotransferase (PuuE) and GABA transporter (GadC) by protein scaffold. 0...
  36. Tovar Gudiño E, Guevara Salazar J, Bahena Herrera J, Trujillo Ferrara J, Martínez Campos Z, Razo Hernández R, et al. Novel-Substituted Heterocyclic GABA Analogues. Enzymatic Activity against the GABA-AT Enzyme from Pseudomonas fluorescens and In Silico Molecular Modeling. Molecules. 2018;23: pubmed publisher
    ..Docking assays were done for these compounds over the GABA-AT enzyme models where 19a showed a strong interaction with both GABA-AT enzymes. ..
  37. Pham V, Somasundaram S, Park S, Lee S, Hong S. Co-Localization of GABA Shunt Enzymes for the Efficient Production of Gamma-Aminobutyric Acid via GABA Shunt Pathway in Escherichia coli. J Microbiol Biotechnol. 2016;26:710-6 pubmed publisher
    ..The GABA shunt enzymes succinate-semialdehyde dehydrogenase (GabD) and GABA aminotransferase (GabT) were co-localized along with the GABA transporter (GadC) by using a synthetic scaffold complex...
  38. Wang R, Lei T, Fu F, Li R, Jing X, Yang X, et al. Application of chromosome microarray analysis in patients with unexplained developmental delay/intellectual disability in South China. Pediatr neonatol. 2019;60:35-42 pubmed publisher
    ..Additionally, there were forty-seven cases of non-syndromic pathogenic CNVs. The ABAT, FTSJ1, DYNC1H1, and SETBP1 genes were identified as DD/ID candidate genes...
  39. Masocha W. Comprehensive analysis of the GABAergic system gene expression profile in the anterior cingulate cortex of mice with Paclitaxel-induced neuropathic pain. Gene Expr. 2015;16:145-53 pubmed publisher
    ..is the main transporter of GABA from the synapse, and thus its increased expression possibly results in less GABA at the synapse and dysregulation of the GABAergic system...
  40. Pitman K, Borgland S, MacLeod B, Puil E. Isovaline does not activate GABA(B) receptor-coupled potassium currents in GABA(B) expressing AtT-20 cells and cultured rat hippocampal neurons. PLoS ONE. 2015;10:e0118497 pubmed publisher
    ..R-isovaline applied either extracellularly (250 μM) or intracellularly (10 μM) did not alter responses to GABA at 1 μM...
  41. Koenig M, Bonnen P. Metabolomics Profile in ABAT Deficiency Pre- and Post-treatment. JIMD Rep. 2019;43:13-17 pubmed publisher
    ..We present the metabolomics profile of two ABAT deficiency patients both pre- and posttreatment with flumazenil...
  42. Li Y, Zhang J, Zhang L, Chen X, Pan Y, Chen S, et al. Systems pharmacology to decipher the combinational anti-migraine effects of Tianshu formula. J Ethnopharmacol. 2015;174:45-56 pubmed publisher
    ..only assist the monarch herb to improve the outcome of migraine patients, but also regulate multiple targets like ABAT, HTR1D, ALOX15 and KCND3 to modify migraine accompanying symptoms like vomiting, vertigo and gastrointestinal ..
  43. Mathew B, Mathew G, Suresh J, Usman D, Shiva Subramanyan P, Safna K. Ligand based drug design of new heterocyclic imines of GABA analogues: A molecular docking approach for the discovery of new GABA-AT inhibitors. Cent Nerv Syst Agents Med Chem. 2016;: pubmed
    Degradation of the inhibitory neurotransmitter ?-aminobutyric acid (GABA) is mainly catalysed by GABA aminotransferase (GABA-AT), excessive activity of which leads to convulsions...
  44. Ichikawa K, Tsuji M, Tsuyusaki Y, Tomiyasu M, Aida N, Goto T. Serial Magnetic Resonance Imaging and 1H-Magnetic Resonance Spectroscopy in GABA Transaminase Deficiency: A Case Report. JIMD Rep. 2019;43:7-12 pubmed publisher
    ..The disease is caused by mutation in the 4-aminobutyrate aminotransferase (ABAT) gene, which encodes an enzyme involved in GABA catabolism...
  45. Yang X, Ke C, Zhu J, Wang Y, Zeng W, Huang J. Enhanced productivity of gamma-amino butyric acid by cascade modifications of a whole-cell biocatalyst. Appl Microbiol Biotechnol. 2018;102:3623-3633 pubmed publisher
    ..15 g/L GABA at 45 °C from L-glutamic acid (L-Glu) with a productivity of 40...
  46. Partap S, Akhtar M, Yar M, Hassan M, Siddiqui A. Pyridazinone hybrids: Design, synthesis and evaluation as potential anticonvulsant agents. Bioorg Chem. 2018;77:74-83 pubmed publisher
    ..In-silico and in vitro studies revealed that some of these hybrid derivatives demonstrated admirable GABA AT inhibitory activity...
  47. Zheng R, Hachisuka S, Tomita H, Imanaka T, Zheng Y, Nishiyama M, et al. An ornithine ω-aminotransferase required for growth in the absence of exogenous proline in the archaeon Thermococcus kodakarensis. J Biol Chem. 2018;293:3625-3636 pubmed publisher
    ..Here, we examined the activity and function of TK2101, a gene annotated as a GABA aminotransferase, from the hyperthermophilic archaeon Thermococcus kodakarensis We overexpressed the TK2101 gene in <..
  48. Maguire S, Rhoades S, Chen W, Sengupta A, Yue Z, Lim J, et al. Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis. J Biol Chem. 2015;290:20407-16 pubmed publisher
    ..In Drosophila, the loss of the specific enzyme that degrades GABA, GABA transaminase (GABAT), increases sleep, and we show here that it also affects metabolism such that flies lacking GABAT ..
  49. Ozguven S, Ones T, Yilmaz Y, Turoglu H, Imeryuz N. The role of active brown adipose tissue in human metabolism. Eur J Nucl Med Mol Imaging. 2016;43:355-361 pubmed publisher
    The presence of activated brown adipose tissue (ABAT) has been associated with a reduced risk of obesity in adults...
  50. Chand N, Muhammad S, Khan R, Alhidary I, Rehman Z. Ameliorative effect of synthetic ?-aminobutyric acid (GABA) on performance traits, antioxidant status and immune response in broiler exposed to cyclic heat stress. Environ Sci Pollut Res Int. 2016;23:23930-23935 pubmed
    ..One group served as a control (basal diet only) while the others were supplemented with GABA at the rate of 25 (GABA-25), 50 (GABA 50), 75 (GABA-75), and 100 (GABA-100) mg/kg feed...
  51. Rochtus A, Winand R, Laenen G, Vangeel E, Izzi B, Wittevrongel C, et al. Methylome analysis for spina bifida shows SOX18 hypomethylation as a risk factor with evidence for a complex (epi)genetic interplay to affect neural tube development. Clin Epigenetics. 2016;8:108 pubmed
    ..CpG-specific methylation differences were next replicated for the top six candidate genes ABAT, CNTNAP1, SLC1A6, SNED1, SOX18, and TEPP but only for the SOX18 locus ..
  52. Nagappa M, Bindu P, Chiplunkar S, Govindaraj P, Narayanappa G, Krishnan A, et al. Hypersomnolence-hyperkinetic movement disorder in a child with compound heterozygous mutation in 4-aminobutyrate aminotransferase (ABAT) gene. Brain Dev. 2017;39:161-165 pubmed publisher
    Deficiency of gamma-amino-butyrate aminotransferase (ABAT) is a rare inherited disorder...
  53. Panosyan E, Lin H, Koster J, Lasky J. In search of druggable targets for GBM amino acid metabolism. BMC Cancer. 2017;17:162 pubmed publisher
    ..All three GABA related genes -- glutamate decarboxylase 1 (GAD1) and 2 (GAD2) and 4-aminobutyrate aminotransferase (ABAT) -- were lower in mesenchymal tumors, which in contrast showed higher IDO1 (indoleamine 2, 3-dioxygenase 1) and ..
  54. Wu R, Sanishvili R, Belitsky B, Juncosa J, Le H, Lehrer H, et al. PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation. Proc Natl Acad Sci U S A. 2017;114:3891-3896 pubmed publisher
    ..Results of in vitro and in vivo assays using full-length GabR support the conclusion that AFPA is an agonistic ligand capable of triggering GabR-mediated transcription activation via formation of an external aldimine with PLP. ..
  55. Jager A, Amiri H, Bielczyk N, van Heukelum S, Heerschap A, Aschrafi A, et al. Cortical control of aggression: GABA signalling in the anterior cingulate cortex. Eur Neuropsychopharmacol. 2017;: pubmed publisher
    ..supported by a 40% reduction of 1H-MRS GABA levels and a 20-fold increase of the GABA-degrading enzyme Abat in the ventral ACC...
  56. Feng H, Forman S. Comparison of αβδ and αβγ GABAA receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacol Res. 2018;133:289-300 pubmed publisher
    ..receptors. Many of these differences are explained by correcting for the high agonist efficacy of GABA at most αβγ receptors vs. much lower efficacy at αβδ receptors...
  57. Schmitt S, Höfner G, Wanner K. Application of MS Transport Assays to the Four Human γ-Aminobutyric Acid Transporters. ChemMedChem. 2015;10:1498-510 pubmed publisher
    ..this approach to all four human GAT subtypes and determined the KM values for GAT-mediated transport of ((2) H6 )GABA at each subtype...
  58. Pham V, Somasundaram S, Lee S, Park S, Hong S. Redirection of Metabolic Flux into Novel Gamma-Aminobutyric Acid Production Pathway by Introduction of Synthetic Scaffolds Strategy in Escherichia Coli. Appl Biochem Biotechnol. 2016;178:1315-24 pubmed publisher
    ..via GABA shunt, which consists of succinate dehydrogenase, succinate-semialdehyde dehydrogenase, and GABA aminotransferase. The three enzymes were physically attached to each other through a synthetic scaffold, and the Krebs ..
  59. Baptista Hon D, Krah A, Zachariae U, Hales T. A role for loop G in the ?1 strand in GABAA receptor activation. J Physiol. 2016;594:5555-71 pubmed publisher
    ..D43C and T47C substitutions reduced the apparent potency of GABA at ?1?2?2 receptors by 50-fold and eight-fold, respectively, whereas the F45C substitution caused a biphasic GABA ..
  60. Edwards A, Olariu I, Nakamura D, Ahn S, Tayade C. Chronic effects of an anti-angiogenic thrombospondin-1 mimetic peptide, ABT-898, on female mouse reproductive outcomes. Reprod Biol Endocrinol. 2016;14:56 pubmed publisher
    ..9-plex assay was performed on plasma samples obtained from mice prior to treatment, during the second week of ABAT-898 or control treatment and on the last day of treatment...
  61. Soupiadou P, Branoner F, Straka H. Pharmacological profile of vestibular inhibitory inputs to superior oblique motoneurons. J Neurol. 2018;265:18-25 pubmed publisher
  62. Karim N, Irshad S, Khan I, Mohammad A, Anis I, Shah M, et al. GABA(A) receptor modulation and neuropharmacological activities of viscosine isolated from Dodonaea viscosa (Linn). Pharmacol Biochem Behav. 2015;136:64-72 pubmed publisher
    ..In conclusion, the results of the present study suggest that the anxiolytic and anticonvulsant actions of viscosine are likely mediated via its positive allosteric modulatory action of GABA at different GABA(A) receptor subtypes.
  63. Gey L, Gernert M, Löscher W. Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models. Neurobiol Dis. 2016;91:194-208 pubmed publisher
    ..The data demonstrate that chronic administration of very low, nontoxic doses of vigabatrin into STN is an effective means of increasing local GABA concentrations and seizure threshold. ..
  64. El Hattab A, Craigen W, Scaglia F. Mitochondrial DNA maintenance defects. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1539-1555 pubmed publisher
    ..proteins that function in maintaining a balanced mitochondrial nucleotide pool (TK2, DGUOK, SUCLG1, SUCLA2, ABAT, RRM2B, TYMP, SLC25A4, AGK, and MPV17), and genes encoding proteins involved in mitochondrial fusion (OPA1, MFN2, ..
  65. Chen C, Sigurdsson H, Pépés S, Auer D, Morris P, Morgan P, et al. Activation induced changes in GABA: Functional MRS at 7T with MEGA-sLASER. Neuroimage. 2017;156:207-213 pubmed publisher
    ..and highly efficient editing performance for GABA detection and the advantage of visually identifying GABA resonances in the spectra, MEGA-sLASER is demonstrated to be an effective method for studying of dynamic changes in GABA at 7T.
  66. Besse A, Petersen A, Hunter J, Appadurai V, Lalani S, Bonnen P. Personalized medicine approach confirms a milder case of ABAT deficiency. Mol Brain. 2016;9:93 pubmed
    ..identified in this patient we developed a cell-based system to test both functions of the ABAT protein via GABA transaminase enzyme activity and mtDNA copy number assays...
  67. Mir J, Zagmutt S, Lichtenstein M, Garcia Villoria J, Weber M, Gracia A, et al. Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex. Mol Neurobiol. 2018;55:7216-7228 pubmed publisher
    ..In the hypothalamus, ghrelin enhances CPT1A activity while GABA transaminase (GABAT) activity, a key enzyme in GABA shunt metabolism, is unaltered...
  68. Cohen B. GABA-transaminase, the liver and infantile autism. Med Hypotheses. 2001;57:673-4 pubmed
    ..due to abnormal development of the axon(s) in the corpus callosum. ..
  69. Kim D, Yoon C, Eum W, Lee B, An J, Lee S, et al. Site-directed mutagenesis of human brain GABA transaminase: lysine-357 is involved in cofactor binding at the active site. Mol Cells. 2004;18:314-9 pubmed
    ..These results indicate that lysine 357 is essential for catalytic function, and is involved in binding PLP at the active site. ..
  70. Mick E, McGough J, Deutsch C, Frazier J, Kennedy D, Goldberg R. Genome-wide association study of proneness to anger. PLoS ONE. 2014;9:e87257 pubmed publisher
    ..These results suggest that signaling pathways regulating intracellular calcium homeostasis, which are relevant to memory, learning, and neuronal survival, may in part underlie the expression of Angry Temperament. ..
  71. Jansen M, Sas L, Sieuwerts A, Van Cauwenberghe C, Ramirez Ardila D, Look M, et al. Decreased expression of ABAT and STC2 hallmarks ER-positive inflammatory breast cancer and endocrine therapy resistance in advanced disease. Mol Oncol. 2015;9:1218-33 pubmed publisher
    ..A metagene of six genes including the genes encoding for 4-aminobutyrate aminotransferase (ABAT) and Stanniocalcin-2 (STC2) were identified to distinguish 22 ER+ IBC from 43 ER+ nIBC patients and remained ..
  72. Farthing C, Farthing D, Gress R, Sweet D. Determination of l-glutamic acid and ?-aminobutyric acid in mouse brain tissue utilizing GC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1068-1069:64-70 pubmed publisher
    ..investigate the effects of deletion of organic anion transporter 1 (Oat1) or Oat3 on murine CNS levels of GA and GABA at 3 and 18 mo of age, as compared to age matched wild-type (WT) animals...
  73. De Biase D, Barra D, Simmaco M, John R, Bossa F. Primary structure and tissue distribution of human 4-aminobutyrate aminotransferase. Eur J Biochem. 1995;227:476-80 pubmed
    ..The human cDNA was used to probe for the presence of 4-aminobutyrate aminotransferase mRNA in human tissues and a significant transcript was found in heart, placenta and in tissues usually associated with the expression of this enzyme. ..
  74. Zhang B, Yuan Y, Jia Y, Yu X, Xu Q, Shen Y, et al. An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia. Eur Psychiatry. 2005;20:45-9 pubmed
    ..Phosphate-activated glutaminase (GLS), glutamine synthetase (GLUL), glutamic acid decarboxylase (GAD), GABA transaminase (ABAT) and succinic semialdehyde dehydrogenase (ALDH5A1) are five primary enzymes in glutamate and GABA ..
  75. Louro P, Ramos L, Robalo C, Cancelinha C, Dinis A, Veiga R, et al. Phenotyping GABA transaminase deficiency: a case description and literature review. J Inherit Metab Dis. 2016;39:743-747 pubmed publisher
    ..It is caused by mutations in the ABAT gene, which encodes 4-aminobutyrate transaminase, an enzyme of GABA catabolism and mitochondrial nucleoside salvage...
  76. Bonatsou S, Iliopoulos V, Mallouchos A, Gogou E, Oikonomopoulou V, Krokida M, et al. Effect of osmotic dehydration of olives as pre-fermentation treatment and partial substitution of sodium chloride by monosodium glutamate in the fermentation profile of Kalamata natural black olives. Food Microbiol. 2017;63:72-83 pubmed publisher
    ..Finally, the sensory assessment of fermented olives with/without osmotic dehydration and at all levels of MSG did not show any deviation compared to the control treatment. ..
  77. Mascarenhas R, Le H, Clevenger K, Lehrer H, Ringe D, Kelleher N, et al. Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Biochemistry. 2017;56:4951-4961 pubmed publisher
  78. Solís González C, Domínguez Malfavón L, Vargas Suárez M, Gaytán I, Cevallos M, Lozano L, et al. Novel Metabolic Pathway for N-Methylpyrrolidone Degradation in Alicycliphilus sp. Strain BQ1. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..If GABA is produced, the activity of a GABA aminotransferase (GABA-AT), not encoded in the nmp gene cluster, is needed to generate SSA...
  79. Taylor Wells J, Senan A, Bermudez I, Jones A. Species specific RNA A-to-I editing of mosquito RDL modulates GABA potency and influences agonistic, potentiating and antagonistic actions of ivermectin. Insect Biochem Mol Biol. 2018;93:1-11 pubmed publisher
    ..For example, ivermectin potentiated currents induced by GABA at the EC20 concentration in the unedited isoform but not in the fully edited variant...
  80. Osei Y, Churchich J. Screening and sequence determination of a cDNA encoding the human brain 4-aminobutyrate aminotransferase. Gene. 1995;155:185-7 pubmed
    ..Using the GenBank and EMBL databases, comparison of the predicted amino-acid sequence of hGaba-t with the pig enzyme revealed 95.4% homology. ..
  81. Barnby G, Abbott A, Sykes N, Morris A, Weeks D, Mott R, et al. Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT. Am J Hum Genet. 2005;76:950-66 pubmed
    ..In the present study, 10 positional candidate genes that map to 16p11-13 were examined for coding variants: A2BP1, ABAT, BFAR, CREBBP, EMP2, GRIN2A, MRTF-B, SSTR5, TBX6, and UBN1...
  82. Tsuji M, Aida N, Obata T, Tomiyasu M, Furuya N, Kurosawa K, et al. A new case of GABA transaminase deficiency facilitated by proton MR spectroscopy. J Inherit Metab Dis. 2010;33:85-90 pubmed publisher
    ..GABA exposure in the central nervous system (CNS) was responsible for the clinical manifestations of GABA transaminase deficiency...
  83. Wegerer M, Adena S, Pfennig A, Czamara D, Sailer U, Bettecken T, et al. Variants within the GABA transaminase (ABAT) gene region are associated with somatosensory evoked EEG potentials in families at high risk for affective disorders. Psychol Med. 2013;43:1207-17 pubmed publisher
    ..response strength 170-370 ms after stimulation) and four single nucleotide polymorphisms within the GABA transaminase (ABAT) gene region coding for a protein responsible for GABA degradation...
  84. Cocco A, Rönnberg A, Jin Z, André G, Vossen L, Bhandage A, et al. Characterization of the ?-aminobutyric acid signaling system in the zebrafish (Danio rerio Hamilton) central nervous system by reverse transcription-quantitative polymerase chain reaction. Neuroscience. 2017;343:300-321 pubmed publisher
    ..GABAB receptors, transporters, glutamate decarboxylases (gads) and 4-aminobutyrate aminotransferase (abat), and associated proteins...
  85. Sahu M, Siddiqui N, Iqbal R, Sharma V, Wakode S. Design, synthesis and evaluation of newer 5,6-dihydropyrimidine-2(1H)-thiones as GABA-AT inhibitors for anticonvulsant potential. Bioorg Chem. 2017;74:166-178 pubmed publisher
    ..42?M and 19.23?M, respectively. The molecular modeling was performed for all the synthesized compounds. The docking results were found in concordant with the observed animal studies. ..
  86. Li C, Wang Q, Ma J, Shi S, Chen X, Yang H, et al. Integrative Pathway Analysis of Genes and Metabolites Reveals Metabolism Abnormal Subpathway Regions and Modules in Esophageal Squamous Cell Carcinoma. Molecules. 2017;22: pubmed publisher
    ..Several prognostic genes, including GPT, ALDH1B1, ABAT, WBSCR22 and MDH1, appeared in the three center modules of the network, suggesting that they can become potentially ..
  87. Jeon S, Bahn J, Jang J, Park J, Kwon O, Cho S, et al. Human brain GABA transaminase tissue distribution and molecular expression. Eur J Biochem. 2000;267:5601-7 pubmed
    ..35 min-1, respectively. Results from inactivation kinetics suggested that human gamma-aminobutyrate transaminase is more sensitive to the vigabatrin drug than the enzyme isolated from bovine brain. ..
  88. Yoon C, Kim D, Jang S, Lee B, Choi H, Choi S, et al. Cysteine-321 of human brain GABA transaminase is involved in intersubunit cross-linking. Mol Cells. 2004;18:214-9 pubmed
    ..These results suggest that the Cys321 residue is essential for the catalytic function of GABA-T, and that it is involved in the formation of a disulfide link between two monomers of human brain GABA-T. ..
  89. Inada T, Koga M, Ishiguro H, Horiuchi Y, Syu A, Yoshio T, et al. Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia. Pharmacogenet Genomics. 2008;18:317-23 pubmed publisher
    ..Redwood City, California, USA). Eight genes (ABAT, ALDH9A1, GABRA3, GABRA4, GABRB2, GABRAG3, GPHN, and SLC6A11) contained polymorphisms with gene-based corrected ..
  90. Jirholt J, Asling B, Hammond P, Davidson G, Knutsson M, Walentinsson A, et al. 4-aminobutyrate aminotransferase (ABAT): genetic and pharmacological evidence for an involvement in gastro esophageal reflux disease. PLoS ONE. 2011;6:e19095 pubmed publisher
    ..a significant genetic association for one SNP located in an intron of the gene 4-aminobutyrate aminotransferase (ABAT) (P(adj)?= 0.027)...
  91. Park S, Park Y, Lee K. Crystal structure of the C-terminal domain of Bacillus subtilis GabR reveals a closed conformation by ?-aminobutyric acid binding, inducing transcriptional activation. Biochem Biophys Res Commun. 2017;487:287-291 pubmed publisher
    ..mechanism, we report the crystal structure of BsGabR-CTD in complex with pyridoxal 5'-phosphate (PLP) and GABA at 2.0 Å resolution...