ABAT

Summary

Gene Symbol: ABAT
Description: 4-aminobutyrate aminotransferase
Alias: GABA-AT, GABAT, NPD009, 4-aminobutyrate aminotransferase, mitochondrial, (S)-3-amino-2-methylpropionate transaminase, 4-aminobutyrate transaminase, GABA aminotransferase, GABA transaminase, GABA transferase, gamma-amino-N-butyrate transaminase
Species: human
Products:     ABAT

Top Publications

  1. Jia P, Wang L, Meltzer H, Zhao Z. Common variants conferring risk of schizophrenia: a pathway analysis of GWAS data. Schizophr Res. 2010;122:38-42 pubmed publisher
    ..The genes involved in these pathways had not been detected by single marker analysis, suggesting this approach may complement the original analysis of GWAS dataset. ..
  2. Medina Kauwe L, Tobin A, De Meirleir L, Jaeken J, Jakobs C, Nyhan W, et al. 4-Aminobutyrate aminotransferase (GABA-transaminase) deficiency. J Inherit Metab Dis. 1999;22:414-27 pubmed
    ..Genomic Southern analysis revealed that the second proband most likely harbours a deletion in the 3' region of the GABA-T gene. ..
  3. Jaeken J, Casaer P, De Cock P, Corbeel L, Eeckels R, Eggermont E, et al. Gamma-aminobutyric acid-transaminase deficiency: a newly recognized inborn error of neurotransmitter metabolism. Neuropediatrics. 1984;15:165-9 pubmed
    ..Postmortem examination of his brain showed leukodystrophy of the type seen in amino acidopathies such as phenylketonuria. This appears to be the first report of gamma-aminobutyric acid-transaminase deficiency. ..
  4. Romei C, Sabolla C, Raiteri L. High-affinity GABA uptake by neuronal GAT1 transporters provokes release of [(3)H]GABA by homoexchange and through GAT1-independent Ca(2+)-mediated mechanisms. Neuropharmacology. 2015;88:164-70 pubmed publisher
    ..The significance of the novel function of the GABA high-affinity uptake here identified deserves further multidisciplinary investigation. ..
  5. Xie M, Chen H, Nie S, Yin J, Xie M. Gamma-Aminobutyric Acid Increases the Production of Short-Chain Fatty Acids and Decreases pH Values in Mouse Colon. Molecules. 2017;22: pubmed publisher
    ..The female Kunming mice were given GABA at doses of 5, 10, 20 and 40 mg/kg/d for 14 days...
  6. ENOCH M, Zhou Z, Kimura M, Mash D, Yuan Q, Goldman D. GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats. PLoS ONE. 2012;7:e29369 pubmed publisher
    ..There were also expression changes specific to cocaine addicts (GAD1, GAD2), alcoholics (GABRA2) and P rats (ABAT, GABRG3)...
  7. Pham V, Somasundaram S, Lee S, Park S, Hong S. Engineering the intracellular metabolism of Escherichia coli to produce gamma-aminobutyric acid by co-localization of GABA shunt enzymes. Biotechnol Lett. 2016;38:321-7 pubmed publisher
    ..produce GABA from glucose by the co-localization of enzymes succinate semialdehyde dehydrogenase (GadD), GABA aminotransferase (PuuE) and GABA transporter (GadC) by protein scaffold. 0...
  8. Tovar Gudiño E, Guevara Salazar J, Bahena Herrera J, Trujillo Ferrara J, Martínez Campos Z, Razo Hernández R, et al. Novel-Substituted Heterocyclic GABA Analogues. Enzymatic Activity against the GABA-AT Enzyme from Pseudomonas fluorescens and In Silico Molecular Modeling. Molecules. 2018;23: pubmed publisher
    ..Docking assays were done for these compounds over the GABA-AT enzyme models where 19a showed a strong interaction with both GABA-AT enzymes. ..
  9. Pham V, Somasundaram S, Park S, Lee S, Hong S. Co-Localization of GABA Shunt Enzymes for the Efficient Production of Gamma-Aminobutyric Acid via GABA Shunt Pathway in Escherichia coli. J Microbiol Biotechnol. 2016;26:710-6 pubmed publisher
    ..The GABA shunt enzymes succinate-semialdehyde dehydrogenase (GabD) and GABA aminotransferase (GabT) were co-localized along with the GABA transporter (GadC) by using a synthetic scaffold complex...

More Information

Publications80

  1. Wang R, Lei T, Fu F, Li R, Jing X, Yang X, et al. Application of chromosome microarray analysis in patients with unexplained developmental delay/intellectual disability in South China. Pediatr neonatol. 2018;: pubmed publisher
    ..Additionally, there were forty-seven cases of non-syndromic pathogenic CNVs. The ABAT, FTSJ1, DYNC1H1, and SETBP1 genes were identified as DD/ID candidate genes...
  2. Koenig M, Bonnen P. Metabolomics Profile in ABAT Deficiency Pre- and Post-treatment. JIMD Rep. 2018;: pubmed publisher
    ..We present the metabolomics profile of two ABAT deficiency patients both pre- and posttreatment with flumazenil...
  3. Pitman K, Borgland S, MacLeod B, Puil E. Isovaline does not activate GABA(B) receptor-coupled potassium currents in GABA(B) expressing AtT-20 cells and cultured rat hippocampal neurons. PLoS ONE. 2015;10:e0118497 pubmed publisher
    ..R-isovaline applied either extracellularly (250 μM) or intracellularly (10 μM) did not alter responses to GABA at 1 μM...
  4. Masocha W. Comprehensive analysis of the GABAergic system gene expression profile in the anterior cingulate cortex of mice with Paclitaxel-induced neuropathic pain. Gene Expr. 2015;16:145-53 pubmed publisher
    ..is the main transporter of GABA from the synapse, and thus its increased expression possibly results in less GABA at the synapse and dysregulation of the GABAergic system...
  5. Ichikawa K, Tsuji M, Tsuyusaki Y, Tomiyasu M, Aida N, Goto T. Serial Magnetic Resonance Imaging and 1H-Magnetic Resonance Spectroscopy in GABA Transaminase Deficiency: A Case Report. JIMD Rep. 2018;: pubmed publisher
    ..The disease is caused by mutation in the 4-aminobutyrate aminotransferase (ABAT) gene, which encodes an enzyme involved in GABA catabolism...
  6. Mathew B, Mathew G, Suresh J, Usman D, Shiva Subramanyan P, Safna K. Ligand based drug design of new heterocyclic imines of GABA analogues: A molecular docking approach for the discovery of new GABA-AT inhibitors. Cent Nerv Syst Agents Med Chem. 2016;: pubmed
    Degradation of the inhibitory neurotransmitter ?-aminobutyric acid (GABA) is mainly catalysed by GABA aminotransferase (GABA-AT), excessive activity of which leads to convulsions...
  7. Yang X, Ke C, Zhu J, Wang Y, Zeng W, Huang J. Enhanced productivity of gamma-amino butyric acid by cascade modifications of a whole-cell biocatalyst. Appl Microbiol Biotechnol. 2018;102:3623-3633 pubmed publisher
    ..15 g/L GABA at 45 °C from L-glutamic acid (L-Glu) with a productivity of 40...
  8. Li Y, Zhang J, Zhang L, Chen X, Pan Y, Chen S, et al. Systems pharmacology to decipher the combinational anti-migraine effects of Tianshu formula. J Ethnopharmacol. 2015;174:45-56 pubmed publisher
    ..only assist the monarch herb to improve the outcome of migraine patients, but also regulate multiple targets like ABAT, HTR1D, ALOX15 and KCND3 to modify migraine accompanying symptoms like vomiting, vertigo and gastrointestinal ..
  9. Partap S, Akhtar M, Yar M, Hassan M, Siddiqui A. Pyridazinone hybrids: Design, synthesis and evaluation as potential anticonvulsant agents. Bioorg Chem. 2018;77:74-83 pubmed publisher
    ..In-silico and in vitro studies revealed that some of these hybrid derivatives demonstrated admirable GABA AT inhibitory activity...
  10. Zheng R, Hachisuka S, Tomita H, Imanaka T, Zheng Y, Nishiyama M, et al. An ornithine ω-aminotransferase required for growth in the absence of exogenous proline in the archaeon Thermococcus kodakarensis. J Biol Chem. 2018;293:3625-3636 pubmed publisher
    ..Here, we examined the activity and function of TK2101, a gene annotated as a GABA aminotransferase, from the hyperthermophilic archaeon Thermococcus kodakarensis We overexpressed the TK2101 gene in <..
  11. Rochtus A, Winand R, Laenen G, Vangeel E, Izzi B, Wittevrongel C, et al. Methylome analysis for spina bifida shows SOX18 hypomethylation as a risk factor with evidence for a complex (epi)genetic interplay to affect neural tube development. Clin Epigenetics. 2016;8:108 pubmed
    ..CpG-specific methylation differences were next replicated for the top six candidate genes ABAT, CNTNAP1, SLC1A6, SNED1, SOX18, and TEPP but only for the SOX18 locus ..
  12. Ozguven S, Ones T, Yilmaz Y, Turoglu H, Imeryuz N. The role of active brown adipose tissue in human metabolism. Eur J Nucl Med Mol Imaging. 2016;43:355-61 pubmed publisher
    The presence of activated brown adipose tissue (ABAT) has been associated with a reduced risk of obesity in adults...
  13. Maguire S, Rhoades S, Chen W, Sengupta A, Yue Z, Lim J, et al. Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis. J Biol Chem. 2015;290:20407-16 pubmed publisher
    ..In Drosophila, the loss of the specific enzyme that degrades GABA, GABA transaminase (GABAT), increases sleep, and we show here that it also affects metabolism such that flies lacking GABAT ..
  14. Chand N, Muhammad S, Khan R, Alhidary I, Rehman Z. Ameliorative effect of synthetic ?-aminobutyric acid (GABA) on performance traits, antioxidant status and immune response in broiler exposed to cyclic heat stress. Environ Sci Pollut Res Int. 2016;23:23930-23935 pubmed
    ..One group served as a control (basal diet only) while the others were supplemented with GABA at the rate of 25 (GABA-25), 50 (GABA 50), 75 (GABA-75), and 100 (GABA-100) mg/kg feed...
  15. Panosyan E, Lin H, Koster J, Lasky J. In search of druggable targets for GBM amino acid metabolism. BMC Cancer. 2017;17:162 pubmed publisher
    ..All three GABA related genes -- glutamate decarboxylase 1 (GAD1) and 2 (GAD2) and 4-aminobutyrate aminotransferase (ABAT) -- were lower in mesenchymal tumors, which in contrast showed higher IDO1 (indoleamine 2, 3-dioxygenase 1) and ..
  16. Feng H, Forman S. Comparison of ??? and ??? GABAA receptors: Allosteric modulation and identification of subunit arrangement by site-selective general anesthetics. Pharmacol Res. 2018;133:289-300 pubmed publisher
    ..receptors. Many of these differences are explained by correcting for the high agonist efficacy of GABA at most ??? receptors vs. much lower efficacy at ??? receptors...
  17. Jager A, Amiri H, Bielczyk N, van Heukelum S, Heerschap A, Aschrafi A, et al. Cortical control of aggression: GABA signalling in the anterior cingulate cortex. Eur Neuropsychopharmacol. 2017;: pubmed publisher
    ..supported by a 40% reduction of 1H-MRS GABA levels and a 20-fold increase of the GABA-degrading enzyme Abat in the ventral ACC...
  18. Nagappa M, Bindu P, Chiplunkar S, Govindaraj P, Narayanappa G, Krishnan A, et al. Hypersomnolence-hyperkinetic movement disorder in a child with compound heterozygous mutation in 4-aminobutyrate aminotransferase (ABAT) gene. Brain Dev. 2017;39:161-165 pubmed publisher
    Deficiency of gamma-amino-butyrate aminotransferase (ABAT) is a rare inherited disorder...
  19. Wu R, Sanishvili R, Belitsky B, Juncosa J, Le H, Lehrer H, et al. PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation. Proc Natl Acad Sci U S A. 2017;114:3891-3896 pubmed publisher
    ..Results of in vitro and in vivo assays using full-length GabR support the conclusion that AFPA is an agonistic ligand capable of triggering GabR-mediated transcription activation via formation of an external aldimine with PLP. ..
  20. Soupiadou P, Branoner F, Straka H. Pharmacological profile of vestibular inhibitory inputs to superior oblique motoneurons. J Neurol. 2018;: pubmed publisher
  21. Schmitt S, Höfner G, Wanner K. Application of MS Transport Assays to the Four Human γ-Aminobutyric Acid Transporters. ChemMedChem. 2015;10:1498-510 pubmed publisher
    ..this approach to all four human GAT subtypes and determined the KM values for GAT-mediated transport of ((2) H6 )GABA at each subtype...
  22. Edwards A, Olariu I, Nakamura D, Ahn S, Tayade C. Chronic effects of an anti-angiogenic thrombospondin-1 mimetic peptide, ABT-898, on female mouse reproductive outcomes. Reprod Biol Endocrinol. 2016;14:56 pubmed publisher
    ..9-plex assay was performed on plasma samples obtained from mice prior to treatment, during the second week of ABAT-898 or control treatment and on the last day of treatment...
  23. Pham V, Somasundaram S, Lee S, Park S, Hong S. Redirection of Metabolic Flux into Novel Gamma-Aminobutyric Acid Production Pathway by Introduction of Synthetic Scaffolds Strategy in Escherichia Coli. Appl Biochem Biotechnol. 2016;178:1315-24 pubmed publisher
    ..via GABA shunt, which consists of succinate dehydrogenase, succinate-semialdehyde dehydrogenase, and GABA aminotransferase. The three enzymes were physically attached to each other through a synthetic scaffold, and the Krebs ..
  24. Baptista Hon D, Krah A, Zachariae U, Hales T. A role for loop G in the ?1 strand in GABAA receptor activation. J Physiol. 2016;594:5555-71 pubmed publisher
    ..D43C and T47C substitutions reduced the apparent potency of GABA at ?1?2?2 receptors by 50-fold and eight-fold, respectively, whereas the F45C substitution caused a biphasic GABA ..
  25. El Hattab A, Craigen W, Scaglia F. Mitochondrial DNA maintenance defects. Biochim Biophys Acta. 2017;1863:1539-1555 pubmed publisher
    ..proteins that function in maintaining a balanced mitochondrial nucleotide pool (TK2, DGUOK, SUCLG1, SUCLA2, ABAT, RRM2B, TYMP, SLC25A4, AGK, and MPV17), and genes encoding proteins involved in mitochondrial fusion (OPA1, MFN2, ..
  26. Karim N, Irshad S, Khan I, Mohammad A, Anis I, Shah M, et al. GABA(A) receptor modulation and neuropharmacological activities of viscosine isolated from Dodonaea viscosa (Linn). Pharmacol Biochem Behav. 2015;136:64-72 pubmed publisher
    ..In conclusion, the results of the present study suggest that the anxiolytic and anticonvulsant actions of viscosine are likely mediated via its positive allosteric modulatory action of GABA at different GABA(A) receptor subtypes.
  27. Gey L, Gernert M, Löscher W. Continuous bilateral infusion of vigabatrin into the subthalamic nucleus: Effects on seizure threshold and GABA metabolism in two rat models. Neurobiol Dis. 2016;91:194-208 pubmed publisher
    ..The data demonstrate that chronic administration of very low, nontoxic doses of vigabatrin into STN is an effective means of increasing local GABA concentrations and seizure threshold. ..
  28. Chen C, Sigurdsson H, Pépés S, Auer D, Morris P, Morgan P, et al. Activation induced changes in GABA: Functional MRS at 7T with MEGA-sLASER. Neuroimage. 2017;156:207-213 pubmed publisher
    ..and highly efficient editing performance for GABA detection and the advantage of visually identifying GABA resonances in the spectra, MEGA-sLASER is demonstrated to be an effective method for studying of dynamic changes in GABA at 7T.
  29. Besse A, Petersen A, Hunter J, Appadurai V, Lalani S, Bonnen P. Personalized medicine approach confirms a milder case of ABAT deficiency. Mol Brain. 2016;9:93 pubmed
    ..identified in this patient we developed a cell-based system to test both functions of the ABAT protein via GABA transaminase enzyme activity and mtDNA copy number assays...
  30. Mir J, Zagmutt S, Lichtenstein M, Garcia Villoria J, Weber M, Gracia A, et al. Ghrelin Causes a Decline in GABA Release by Reducing Fatty Acid Oxidation in Cortex. Mol Neurobiol. 2018;55:7216-7228 pubmed publisher
    ..In the hypothalamus, ghrelin enhances CPT1A activity while GABA transaminase (GABAT) activity, a key enzyme in GABA shunt metabolism, is unaltered...
  31. Farthing C, Farthing D, Gress R, Sweet D. Determination of l-glutamic acid and ?-aminobutyric acid in mouse brain tissue utilizing GC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1068-1069:64-70 pubmed publisher
    ..investigate the effects of deletion of organic anion transporter 1 (Oat1) or Oat3 on murine CNS levels of GA and GABA at 3 and 18 mo of age, as compared to age matched wild-type (WT) animals...
  32. Cohen B. GABA-transaminase, the liver and infantile autism. Med Hypotheses. 2001;57:673-4 pubmed
    ..due to abnormal development of the axon(s) in the corpus callosum. ..
  33. Jansen M, Sas L, Sieuwerts A, Van Cauwenberghe C, Ramirez Ardila D, Look M, et al. Decreased expression of ABAT and STC2 hallmarks ER-positive inflammatory breast cancer and endocrine therapy resistance in advanced disease. Mol Oncol. 2015;9:1218-33 pubmed publisher
    ..A metagene of six genes including the genes encoding for 4-aminobutyrate aminotransferase (ABAT) and Stanniocalcin-2 (STC2) were identified to distinguish 22 ER+ IBC from 43 ER+ nIBC patients and remained ..
  34. Kim D, Yoon C, Eum W, Lee B, An J, Lee S, et al. Site-directed mutagenesis of human brain GABA transaminase: lysine-357 is involved in cofactor binding at the active site. Mol Cells. 2004;18:314-9 pubmed
    ..These results indicate that lysine 357 is essential for catalytic function, and is involved in binding PLP at the active site. ..
  35. Mick E, McGough J, Deutsch C, Frazier J, Kennedy D, Goldberg R. Genome-wide association study of proneness to anger. PLoS ONE. 2014;9:e87257 pubmed publisher
    ..These results suggest that signaling pathways regulating intracellular calcium homeostasis, which are relevant to memory, learning, and neuronal survival, may in part underlie the expression of Angry Temperament. ..
  36. Zhang B, Yuan Y, Jia Y, Yu X, Xu Q, Shen Y, et al. An association study between polymorphisms in five genes in glutamate and GABA pathway and paranoid schizophrenia. Eur Psychiatry. 2005;20:45-9 pubmed
    ..Phosphate-activated glutaminase (GLS), glutamine synthetase (GLUL), glutamic acid decarboxylase (GAD), GABA transaminase (ABAT) and succinic semialdehyde dehydrogenase (ALDH5A1) are five primary enzymes in glutamate and GABA ..
  37. De Biase D, Barra D, Simmaco M, John R, Bossa F. Primary structure and tissue distribution of human 4-aminobutyrate aminotransferase. Eur J Biochem. 1995;227:476-80 pubmed
    ..The human cDNA was used to probe for the presence of 4-aminobutyrate aminotransferase mRNA in human tissues and a significant transcript was found in heart, placenta and in tissues usually associated with the expression of this enzyme. ..
  38. Louro P, Ramos L, Robalo C, Cancelinha C, Dinis A, Veiga R, et al. Phenotyping GABA transaminase deficiency: a case description and literature review. J Inherit Metab Dis. 2016;39:743-747 pubmed publisher
    ..It is caused by mutations in the ABAT gene, which encodes 4-aminobutyrate transaminase, an enzyme of GABA catabolism and mitochondrial nucleoside salvage...
  39. Taylor Wells J, Senan A, Bermudez I, Jones A. Species specific RNA A-to-I editing of mosquito RDL modulates GABA potency and influences agonistic, potentiating and antagonistic actions of ivermectin. Insect Biochem Mol Biol. 2018;93:1-11 pubmed publisher
    ..For example, ivermectin potentiated currents induced by GABA at the EC20 concentration in the unedited isoform but not in the fully edited variant...
  40. Bonatsou S, Iliopoulos V, Mallouchos A, Gogou E, Oikonomopoulou V, Krokida M, et al. Effect of osmotic dehydration of olives as pre-fermentation treatment and partial substitution of sodium chloride by monosodium glutamate in the fermentation profile of Kalamata natural black olives. Food Microbiol. 2017;63:72-83 pubmed publisher
    ..Finally, the sensory assessment of fermented olives with/without osmotic dehydration and at all levels of MSG did not show any deviation compared to the control treatment. ..
  41. Mascarenhas R, Le H, Clevenger K, Lehrer H, Ringe D, Kelleher N, et al. Selective Targeting by a Mechanism-Based Inactivator against Pyridoxal 5'-Phosphate-Dependent Enzymes: Mechanisms of Inactivation and Alternative Turnover. Biochemistry. 2017;56:4951-4961 pubmed publisher
  42. Solís González C, Domínguez Malfavón L, Vargas Suárez M, Gaytán I, Cevallos M, Lozano L, et al. Novel Metabolic Pathway for N-Methylpyrrolidone Degradation in Alicycliphilus sp. Strain BQ1. Appl Environ Microbiol. 2018;84: pubmed publisher
    ..If GABA is produced, the activity of a GABA aminotransferase (GABA-AT), not encoded in the nmp gene cluster, is needed to generate SSA...
  43. Barnby G, Abbott A, Sykes N, Morris A, Weeks D, Mott R, et al. Candidate-gene screening and association analysis at the autism-susceptibility locus on chromosome 16p: evidence of association at GRIN2A and ABAT. Am J Hum Genet. 2005;76:950-66 pubmed
    ..In the present study, 10 positional candidate genes that map to 16p11-13 were examined for coding variants: A2BP1, ABAT, BFAR, CREBBP, EMP2, GRIN2A, MRTF-B, SSTR5, TBX6, and UBN1...
  44. Osei Y, Churchich J. Screening and sequence determination of a cDNA encoding the human brain 4-aminobutyrate aminotransferase. Gene. 1995;155:185-7 pubmed
    ..Using the GenBank and EMBL databases, comparison of the predicted amino-acid sequence of hGaba-t with the pig enzyme revealed 95.4% homology. ..
  45. Wegerer M, Adena S, Pfennig A, Czamara D, Sailer U, Bettecken T, et al. Variants within the GABA transaminase (ABAT) gene region are associated with somatosensory evoked EEG potentials in families at high risk for affective disorders. Psychol Med. 2013;43:1207-17 pubmed publisher
    ..response strength 170-370 ms after stimulation) and four single nucleotide polymorphisms within the GABA transaminase (ABAT) gene region coding for a protein responsible for GABA degradation...
  46. Tsuji M, Aida N, Obata T, Tomiyasu M, Furuya N, Kurosawa K, et al. A new case of GABA transaminase deficiency facilitated by proton MR spectroscopy. J Inherit Metab Dis. 2010;33:85-90 pubmed publisher
    ..GABA exposure in the central nervous system (CNS) was responsible for the clinical manifestations of GABA transaminase deficiency...
  47. Li C, Wang Q, Ma J, Shi S, Chen X, Yang H, et al. Integrative Pathway Analysis of Genes and Metabolites Reveals Metabolism Abnormal Subpathway Regions and Modules in Esophageal Squamous Cell Carcinoma. Molecules. 2017;22: pubmed publisher
    ..Several prognostic genes, including GPT, ALDH1B1, ABAT, WBSCR22 and MDH1, appeared in the three center modules of the network, suggesting that they can become potentially ..
  48. Sahu M, Siddiqui N, Iqbal R, Sharma V, Wakode S. Design, synthesis and evaluation of newer 5,6-dihydropyrimidine-2(1H)-thiones as GABA-AT inhibitors for anticonvulsant potential. Bioorg Chem. 2017;74:166-178 pubmed publisher
    ..42?M and 19.23?M, respectively. The molecular modeling was performed for all the synthesized compounds. The docking results were found in concordant with the observed animal studies. ..
  49. Cocco A, Rönnberg A, Jin Z, André G, Vossen L, Bhandage A, et al. Characterization of the ?-aminobutyric acid signaling system in the zebrafish (Danio rerio Hamilton) central nervous system by reverse transcription-quantitative polymerase chain reaction. Neuroscience. 2017;343:300-321 pubmed publisher
    ..GABAB receptors, transporters, glutamate decarboxylases (gads) and 4-aminobutyrate aminotransferase (abat), and associated proteins...
  50. Nardone S, Sams D, Zito A, Reuveni E, Elliott E. Dysregulation of Cortical Neuron DNA Methylation Profile in Autism Spectrum Disorder. Cereb Cortex. 2017;27:5739-5754 pubmed publisher
    ..58 differentially methylated regions (DMRs) that included loci associated to GABAergic system genes, particularly ABAT and GABBR1, and brain-specific MicroRNAs...
  51. Kumar N, Dubey A, Upadhyay A, Gautam A, Ranjan R, Srikishna S, et al. GABA accretion reduces Lsi-1 and Lsi-2 gene expressions and modulates physiological responses in Oryza sativa to provide tolerance towards arsenic. Sci Rep. 2017;7:8786 pubmed publisher
    ..accumulation of GABA was highly efficient to provide tolerance to plants against As(III), while higher level of GABA at short term was toxic...
  52. Dobberthien B, Tessier A, Yahya A. Improved resolution of glutamate, glutamine and ?-aminobutyric acid with optimized point-resolved spectroscopy sequence timings for their simultaneous quantification at 9.4 T. NMR Biomed. 2017;: pubmed publisher
    ..4 T. Quantification was based on the proton resonances of Gln, Glu and GABA at ?2.45, ?2.35 and ?2.28 ppm, respectively...
  53. Pandit S, Lee G, Park J. Developmental changes in GABAA tonic inhibition are compromised by multiple mechanisms in preadolescent dentate gyrus granule cells. Korean J Physiol Pharmacol. 2017;21:695-702 pubmed publisher
    ..The facilitation of Itonic by SNAP-5114, a GAT-3 inhibitor, was negligible in the absence of exogenous GABA at all tested ages...
  54. Park S, Park Y, Lee K. Crystal structure of the C-terminal domain of Bacillus subtilis GabR reveals a closed conformation by ?-aminobutyric acid binding, inducing transcriptional activation. Biochem Biophys Res Commun. 2017;487:287-291 pubmed publisher
    ..mechanism, we report the crystal structure of BsGabR-CTD in complex with pyridoxal 5'-phosphate (PLP) and GABA at 2.0 Å resolution...
  55. Inada T, Koga M, Ishiguro H, Horiuchi Y, Syu A, Yoshio T, et al. Pathway-based association analysis of genome-wide screening data suggest that genes associated with the gamma-aminobutyric acid receptor signaling pathway are involved in neuroleptic-induced, treatment-resistant tardive dyskinesia. Pharmacogenet Genomics. 2008;18:317-23 pubmed publisher
    ..Redwood City, California, USA). Eight genes (ABAT, ALDH9A1, GABRA3, GABRA4, GABRB2, GABRAG3, GPHN, and SLC6A11) contained polymorphisms with gene-based corrected ..
  56. Ng C, Duke R, Hinton T, Johnston G. Effects of bilobalide, ginkgolide B and picrotoxinin on GABAA receptor modulation by structurally diverse positive modulators. Eur J Pharmacol. 2017;806:83-90 pubmed publisher
    ..and ginkgolide B, active constituents of Ginkgo biloba, have been shown to negatively modulate the action of GABA at ?1?2?2L GABAA receptors...
  57. Jeon S, Bahn J, Jang J, Park J, Kwon O, Cho S, et al. Human brain GABA transaminase tissue distribution and molecular expression. Eur J Biochem. 2000;267:5601-7 pubmed
    ..35 min-1, respectively. Results from inactivation kinetics suggested that human gamma-aminobutyrate transaminase is more sensitive to the vigabatrin drug than the enzyme isolated from bovine brain. ..
  58. Jirholt J, Asling B, Hammond P, Davidson G, Knutsson M, Walentinsson A, et al. 4-aminobutyrate aminotransferase (ABAT): genetic and pharmacological evidence for an involvement in gastro esophageal reflux disease. PLoS ONE. 2011;6:e19095 pubmed publisher
    ..a significant genetic association for one SNP located in an intron of the gene 4-aminobutyrate aminotransferase (ABAT) (P(adj)?= 0.027)...
  59. Yoon C, Kim D, Jang S, Lee B, Choi H, Choi S, et al. Cysteine-321 of human brain GABA transaminase is involved in intersubunit cross-linking. Mol Cells. 2004;18:214-9 pubmed
    ..These results suggest that the Cys321 residue is essential for the catalytic function of GABA-T, and that it is involved in the formation of a disulfide link between two monomers of human brain GABA-T. ..
  60. Hearl W, Churchich J. Interactions between 4-aminobutyrate aminotransferase and succinic semialdehyde dehydrogenase, two mitochondrial enzymes. J Biol Chem. 1984;259:11459-63 pubmed
  61. Nam H, Jun S. Association between active brown adipose tissue and coronary artery calcification in healthy men. Nuklearmedizin. 2017;56:184-190 pubmed publisher
    We compared various clinical factors between persons with active brown adipose tissue (ABAT) and matched controls, and investigated the relationship between the presence of ABAT and coronary artery calcification (CAC) with respect to ..
  62. Jeremiah S, Povey S. The biochemical genetics of human gamma-aminobutyric acid transaminase. Ann Hum Genet. 1981;45:231-6 pubmed
    1. Two methods have been devised for the detection after electrophoresis of gamma-aminobutyric acid transaminase (GABAT) isozymes. 2. GABAT isozymes can be detected in liver, brain, kidney, pancreas, heart, testis...
  63. Parviz M, Vogel K, Gibson K, Pearl P. Disorders of GABA metabolism: SSADH and GABA-transaminase deficiencies. J Pediatr Epilepsy. 2014;3:217-227 pubmed
    ..GABA-transaminase deficiency is associated with a severe neonatal-infantile epileptic encephalopathy. ..
  64. Rainesalo S, Saransaari P, Peltola J, Keränen T. Uptake of GABA and activity of GABA-transaminase in platelets from epileptic patients. Epilepsy Res. 2003;53:233-9 pubmed
    ..The observed peripheral alterations may indicate an impairment in the function of brain GABAergic systems. ..
  65. Shandra O, Moshe S, Galanopoulou A. Inflammation in Epileptic Encephalopathies. Adv Protein Chem Struct Biol. 2017;108:59-84 pubmed publisher
    ..treatment options include hormonal treatment (adrenocorticotropic hormone and high-dose steroids) and the GABA aminotransferase inhibitor vigabatrin, while ketogenic diet can be given as add-on treatment in refractory IS...
  66. Ramirez A, Lynes M, Shamsi F, Xue R, Tseng Y, Kahn C, et al. Integrating Extracellular Flux Measurements and Genome-Scale Modeling Reveals Differences between Brown and White Adipocytes. Cell Rep. 2017;21:3040-3048 pubmed publisher
    ..Predictions matched experimental data for the metabolite 4-aminobutyrate, the protein ABAT, and the fluxes for glucose, glutamine, and palmitate...
  67. Madjroh N, Olander E, Bundgaard C, Söderhielm P, Jensen A. Functional properties and mechanism of action of PPTQ, an allosteric agonist and low nanomolar positive allosteric modulator at GABAA receptors. Biochem Pharmacol. 2018;147:153-169 pubmed publisher
    ..Whereas PPTQ exclusively increased the potency of GABA at the ?1?2?2S receptor, it increased both GABA potency and efficacy at ?4
  68. Takeuchi K. GABA, a primary metabolite controlled by the Gac/Rsm regulatory pathway, favors a planktonic over a biofilm lifestyle in Pseudomonas protegens CHA0. Mol Plant Microbe Interact. 2017;: pubmed publisher
    ..The gabT gene encoded ?-aminobutyrate transaminase (GABAT) and enabled the growth of the bacterium on GABA, whereas the upstream gabD gene (annotated as a gene encoding ..
  69. Wang R, Lei T, Fu F, Li R, Jing X, Yang X, et al. [Application of chromosome microarray analysis in 489 children with developmental delay/intellectual disability]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2017;34:528-533 pubmed publisher
    ..Forty-seven cases had de novo pathogenic CNVs. ABAT, PMM2, FTSJ1, DYNC1H1 and SETBP1 were considered as candidate genes for DD/ID...
  70. Louis E, Hernandez N, Dyke J, Ma R, Dydak U. In Vivo Dentate Nucleus Gamma-aminobutyric Acid Concentration in Essential Tremor vs. Controls. Cerebellum. 2018;17:165-172 pubmed publisher
    ..PCs are a major storehouse of central nervous system gamma-aminobutyric acid (GABA), releasing GABA at the level of the dentate nucleus...