AANAT

Summary

Gene Symbol: AANAT
Description: aralkylamine N-acetyltransferase
Alias: DSPS, SNAT, serotonin N-acetyltransferase, arylalkylamine N-acetyltransferase, serotonin acetylase
Species: human
Products:     AANAT

Top Publications

  1. Coon S, Mazuruk K, Bernard M, Roseboom P, Klein D, Rodriguez I. The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression. Genomics. 1996;34:76-84 pubmed
    Serotonin N-acetyltransferase (arylalkylamine N-acetyltransferase, AA-NAT, HGMW-approved symbol AANAT; EC 2.3.1...
  2. Wang C, Jones R, Debiec Rychter M, Soos G, Haas G. Correlation of the genotypes for N-acetyltransferases 1 and 2 with double bladder and prostate cancers in a case-comparison study. Anticancer Res. 2002;22:3529-35 pubmed
    ..13 of 34 controls (odds ratio 3.88; p = 0.040). Rapid NAT2 genotype correlated significantly with the development of double prostate-bladder cancer. ..
  3. He C, Ma T, Shi J, Zhang Z, Wang J, Zhu K, et al. Melatonin and its receptor MT1 are involved in the downstream reaction to luteinizing hormone and participate in the regulation of luteinization in different species. J Pineal Res. 2016;61:279-90 pubmed publisher
    ..In cumulus cells, serotonin N-acetyltransferase (SNAT) was also upregulated by hCG and led to elevated melatonin levels in ovarian follicle fluid...
  4. Leng P, Zhao F, Yin B, Ye B. A novel, colorimetric method for biogenic amine detection based on arylalkylamine N-acetyltransferase. Chem Commun (Camb). 2015;51:8712-4 pubmed publisher
    ..a novel colorimetric method for rapid detection of biogenic amines based on arylalkylamine N-acetyltransferase (aaNAT)...
  5. Cao J, Bian J, Wang Z, Dong Y, Chen Y. Effect of monochromatic light on circadian rhythmic expression of clock genes and arylalkylamine N-acetyltransferase in chick retina. Chronobiol Int. 2017;34:1149-1157 pubmed publisher
    ..investigate the effect of color of light on the expression of clock genes and arylalkylamine N-acetyltransferase (Aanat) mRNA expression in chick retina...
  6. Chen Z, Rao J. Positron Emission Tomography Imaging of Tumor Apoptosis with a Caspase-Sensitive Nano-Aggregation Tracer [18F]C-SNAT. Methods Mol Biol. 2018;1790:181-195 pubmed publisher
    ..We have developed a new small molecule probe ([18F]C-SNAT) for positron emission tomography (PET) imaging of apoptosis...
  7. Cazaméa Catalan D, Besseau L, Falcón J, Magnanou E. The timing of Timezyme diversification in vertebrates. PLoS ONE. 2014;9:e112380 pubmed publisher
    ..Its nocturnal surge is primarily due to the rhythmic activity of the arylalkylamine N-acetyl transferase AANAT, which thus became the focus of many investigations regarding its evolution and function...
  8. Li J, You X, Bian C, Yu H, Coon S, Shi Q. Molecular Evolution of Aralkylamine N-Acetyltransferase in Fish: A Genomic Survey. Int J Mol Sci. 2015;17: pubmed publisher
    ..Due to rhythmic activity of the timezyme aralkylamine N-acetyltransferase (AANAT), the blood level of melatonin increases at night and decreases during daytime...
  9. Witney T, Hoehne A, Reeves R, Ilovich O, Namavari M, Shen B, et al. A Systematic Comparison of 18F-C-SNAT to Established Radiotracer Imaging Agents for the Detection of Tumor Response to Treatment. Clin Cancer Res. 2015;21:3896-905 pubmed publisher
    ..It has been shown that the uptake of (18)F-C-SNAT can be used to detect early response to therapy in tumors by positron emission tomography (PET) via a mechanism of ..

More Information

Publications101 found, 100 shown here

  1. Han Y, Onori P, Meng F, Demorrow S, Venter J, Francis H, et al. Prolonged exposure of cholestatic rats to complete dark inhibits biliary hyperplasia and liver fibrosis. Am J Physiol Gastrointest Liver Physiol. 2014;307:G894-904 pubmed publisher
    ..Since melatonin synthesis (by the enzyme serotonin N-acetyltransferase, AANAT) from the pineal gland increases after dark exposure, we hypothesized that biliary hyperplasia and liver fibrosis ..
  2. Rabstein S, Harth V, Justenhoven C, Pesch B, Plöttner S, Heinze E, et al. Polymorphisms in circadian genes, night work and breast cancer: results from the GENICA study. Chronobiol Int. 2014;31:1115-22 pubmed publisher
    ..in circadian genes (CLOCK, NPAS2, ARTNL, PER2 and CRY2), genes of melatonin biosynthesis and signaling (AANAT and MTNR1B) and breast cancer were analyzed with conditional logistic regression models, adjusted for potential ..
  3. Gupta S, Haldar C, Ahmad R. Photoperiodic regulation of nuclear melatonin receptor RORα in lymphoid organs of a tropical rodent Funambulus pennanti: role in seasonal oxidative stress. J Photochem Photobiol B. 2015;142:141-53 pubmed publisher
    ..Further, peripheral melatonin level enhanced the AANAT activity as well as the melatonin synthesis in the lymphoid tissues...
  4. Pagan C, Goubran Botros H, Delorme R, Benabou M, Lemière N, Murray K, et al. Disruption of melatonin synthesis is associated with impaired 14-3-3 and miR-451 levels in patients with autism spectrum disorders. Sci Rep. 2017;7:2096 pubmed publisher
    ..for melatonin deficit in ASD, involving a reduction of both enzyme activities contributing to melatonin synthesis (AANAT and ASMT), observed in the pineal gland as well as in gut and platelets of patients...
  5. Yang M, Tao J, Wu H, Zhang L, Yao Y, Liu L, et al. Responses of Transgenic Melatonin-Enriched Goats on LPS Stimulation and the Proteogenomic Profiles of Their PBMCs. Int J Mol Sci. 2018;19: pubmed publisher
    ..In the current study, we created a MT-enriched animal model (goats) overexpressing the MT synthetase gene Aanat. The responses of these animals to lipopolysaccharide (LPS) stimulation were systematically studied...
  6. Byeon Y, Yool Lee H, Choi D, Back K. Chloroplast-encoded serotonin N-acetyltransferase in the red alga Pyropia yezoensis: gene transition to the nucleus from chloroplasts. J Exp Bot. 2015;66:709-17 pubmed publisher
    ..the N-acetylation of arylalkylamines such as serotonin, which is catalysed by serotonin N-acetyltransferase (SNAT), the penultimate enzyme of melatonin biosynthesis in both animals and plants...
  7. Dempsey D, Jeffries K, Bond J, Carpenter A, Rodriguez Ospina S, Breydo L, et al. Mechanistic and structural analysis of Drosophila melanogaster arylalkylamine N-acetyltransferases. Biochemistry. 2014;53:7777-93 pubmed publisher
    Arylalkylamine N-acetyltransferase (AANAT) catalyzes the penultimate step in the biosynthesis of melatonin and other N-acetylarylalkylamides from the corresponding arylalkylamine and acetyl-CoA...
  8. Shibata T, Musha T, Kubo M, Horie Y, Asahi T, Kuwayama N, et al. Neuronal activity topography parameters as a marker for differentiating vascular cognitive impairment in carotid stenosis. J Stroke Cerebrovasc Dis. 2014;23:2384-90 pubmed publisher
    ..In this technique, cerebral neuronal activities are characterized by the signal intensity and coherence (sNAT and vNAT, respectively)...
  9. Lee H, Byeon Y, Lee K, Lee H, Back K. Cloning of Arabidopsis serotonin N-acetyltransferase and its role with caffeic acid O-methyltransferase in the biosynthesis of melatonin in vitro despite their different subcellular localizations. J Pineal Res. 2014;57:418-26 pubmed publisher
    Serotonin N-acetyltransferase (SNAT) is the penultimate enzyme in melatonin biosynthesis. We cloned SNAT from Arabidopsis thaliana (AtSNAT) and functionally characterized this enzyme for the first time from dicotyledonous plants...
  10. Haghighi F, Ge Y, Chen S, Xin Y, Umali M, De Gasperi R, et al. Neuronal DNA Methylation Profiling of Blast-Related Traumatic Brain Injury. J Neurotrauma. 2015;32:1200-9 pubmed publisher
    ..2 fold change in gene expression of the serotonin N-acetyltransferase gene (Aanat) in blast animals (p<0.05)...
  11. Pačesová D, Novotny J, Bendova Z. The effect of chronic morphine or methadone exposure and withdrawal on clock gene expression in the rat suprachiasmatic nucleus and AA-NAT activity in the pineal gland. Physiol Res. 2016;65:517-25 pubmed
    ..This suggests that withdrawal from methadone, a widely used drug for the treatment of opioid dependence, may have stronger impact on melatonin synthesis than withdrawal from morphine. ..
  12. Kulczykowska E, Kleszczyńska A, Gozdowska M, Sokołowska E. The time enzyme in melatonin biosynthesis in fish: Day/night expressions of three aralkylamine N-acetyltransferase genes in three-spined stickleback. Comp Biochem Physiol A Mol Integr Physiol. 2017;208:46-53 pubmed publisher
    In vertebrates, aralkylamine N-acetyltransferase (AANAT; EC 2.3.1.87) is a time-keeping enzyme in melatonin (Mel) biosynthesis...
  13. Tan D, Zheng X, Kong J, Manchester L, Hardeland R, Kim S, et al. Fundamental issues related to the origin of melatonin and melatonin isomers during evolution: relation to their biological functions. Int J Mol Sci. 2014;15:15858-90 pubmed publisher
    ..Phylogenic analysis based on its rate-limiting synthetic enzyme, serotonin N-acetyltransferase (SNAT), indicates its multiple origins during evolution...
  14. Hägglund M, Hellsten S, Bagchi S, Philippot G, Löfqvist E, Nilsson V, et al. Transport of L-glutamine, L-alanine, L-arginine and L-histidine by the neuron-specific Slc38a8 (SNAT8) in CNS. J Mol Biol. 2015;427:1495-512 pubmed publisher
    ..transporters from the family, and we suggest that the encoded protein should be named SNAT8 to adhere with the SNAT nomenclature...
  15. Soliman A, Lacasse A, Lanoix D, Sagrillo Fagundes L, Boulard V, Vaillancourt C. Placental melatonin system is present throughout pregnancy and regulates villous trophoblast differentiation. J Pineal Res. 2015;59:38-46 pubmed publisher
    ..The purpose of this study was to determine melatonin-synthesizing enzymes, arylalkylamine N-acetyltransferase (AANAT) and hydroxyindole O-methyltransferase (HIOMT), and melatonin receptors (MT1 and MT2) expression throughout ..
  16. van Wijk I, van den Bulk B, Euser S, Bakermans Kranenburg M, van IJzendoorn M, Huffmeijer R. Social judgments, frontal asymmetry, and aggressive behavior in young children: A replication study using EEG. Neuropsychologia. 2017;: pubmed publisher
    ..We developed the Social Network Aggression Task - Early Childhood (SNAT-EC) to examine the mediating role of frontal EEG asymmetry in the relation between social judgment and aggressive ..
  17. Saha S, Singh K, Gupta B. Melatonin synthesis and clock gene regulation in the pineal organ of teleost fish compared to mammals: Similarities and differences. Gen Comp Endocrinol. 2018;: pubmed publisher
    ..melatonin in a rhythmic manner due to the circadian rhythm in the activity of arylalkylamine N-acetyltransferase (AANAT) - the rate-limiting enzyme in melatonin synthesis pathway...
  18. Herman A, Bochenek J, Skipor J, Król K, Krawczyńska A, Antushevich H, et al. Interleukin-1 β Modulates Melatonin Secretion in Ovine Pineal Gland: Ex Vivo Study. Biomed Res Int. 2015;2015:526464 pubmed publisher
    ..Our study proves that IL-1β suppresses melatonin secretion and its action seems to be targeted on the reduction of pineal AA-NAT protein expression. ..
  19. Aboalroub A, Zhang Z, Keramisanou D, Gelis I. Backbone resonance assignment of an insect arylalkylamine N-acetyltransferase from Bombyx mori reveals conformational heterogeneity. Biomol NMR Assign. 2017;11:105-109 pubmed publisher
    ..Although a single AANAT has been identified in mammals, insects utilize multiple AANATs in a diverse array of biological processes...
  20. Singh K, Saha S, Gupta B. Season-dependent effects of photoperiod and temperature on circadian rhythm of arylalkylamine N-acetyltransferase2 gene expression in pineal organ of an air-breathing catfish, Clarias gariepinus. J Photochem Photobiol B. 2017;173:140-149 pubmed publisher
    Arylalkylamine N-acetyltransferase (AANAT) activity, aanat gene expression and melatonin production have been reported to exhibit prominent circadian rhythm in the pineal organ of most species of fish...
  21. Lee H, Kim T, Kim H, Jung Y, Lee D, Lee K, et al. Heterogeneous ribonucleoprotein R regulates arylalkylamine N-acetyltransferase synthesis via internal ribosomal entry site-mediated translation in a circadian manner. J Pineal Res. 2015;59:518-29 pubmed publisher
    Rhythmic arylalkylamine N-acetyltransferase (AANAT) synthesis is a prominent circadian-controlled response that occurs in most mammals...
  22. García Marín R, Fernández Santos J, Morillo Bernal J, Gordillo Martinez F, Vázquez Román V, Utrilla J, et al. Melatonin in the thyroid gland: regulation by thyroid-stimulating hormone and role in thyroglobulin gene expression. J Physiol Pharmacol. 2015;66:643-52 pubmed
    ..Our results show that the key enzymes for melatonin biosynthesis (AANAT and ASMT) are regulated by thyroid-stimulating hormone...
  23. Tan D, Manchester L, Qin L, Reiter R. Melatonin: A Mitochondrial Targeting Molecule Involving Mitochondrial Protection and Dynamics. Int J Mol Sci. 2016;17: pubmed publisher
    ..by the recent discovery that aralkylamine N-acetyltransferase/serotonin N-acetyltransferase (AANAT/SNAT) is localized in mitochondria of oocytes and the isolated mitochondria generate melatonin...
  24. Lee K, Back K. Overexpression of rice serotonin N-acetyltransferase 1 in transgenic rice plants confers resistance to cadmium and senescence and increases grain yield. J Pineal Res. 2017;62: pubmed publisher
    While ectopic overexpression of serotonin N-acetyltransferase (SNAT) in plants has been accomplished using animal SNAT genes, ectopic overexpression of plant SNAT genes in plants has not been investigated...
  25. Chojnacki C, Błasiak J, Fichna J, Chojnacki J, Popławski T. Evaluation of Melatonin Secretion and Metabolism Exponents in Patients with Ulcerative and Lymphocytic Colitis. Molecules. 2018;23: pubmed publisher
    ..of the melatonin-synthesizing enzymes tryptophan hydroxylase (TPH1), arylalkylamine-N-acetyltransferase (AANAT), and N-acetylserotonin methyltransferase (ASMT) in the colonic mucosa and urinary excretion of 6-..
  26. Xu X, Liu X, Ma S, Xu Y, Xu Y, Guo X, et al. Association of Melatonin Production with Seasonal Changes, Low Temperature, and Immuno-Responses in Hamsters. Molecules. 2018;23: pubmed publisher
    ..Cold temperature per se can upregulate the expressions of melatonin synthetic gene AANAT and ASMT, which are the important enzymes for melatonin biosynthesis...
  27. Chen Y, Rosario F, Shehab M, Powell T, Gupta M, Jansson T. Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR. Clin Sci (Lond). 2015;129:1131-41 pubmed publisher
    ..modulating the ubiquitination and plasma membrane trafficking of sodium-coupled neutral amino acid transporter 2 (SNAT-2) in cultured primary human trophoblast cells...
  28. Rohde K, Bering T, Furukawa T, Rath M. A modulatory role of the Rax homeobox gene in mature pineal gland function: Investigating the photoneuroendocrine circadian system of a Rax conditional knockout mouse. J Neurochem. 2017;143:100-111 pubmed publisher
    ..Telemetric analyses confirmed the lack of a functional circadian clock. Arylalkylamine N-acetyltransferase (Aanat) transcripts, encoding the melatonin rhythm-generating enzyme, were undetectable in the pineal gland of the Rax ..
  29. Rath M, Coon S, Amaral F, Weller J, Møller M, Klein D. Melatonin Synthesis: Acetylserotonin O-Methyltransferase (ASMT) Is Strongly Expressed in a Subpopulation of Pinealocytes in the Male Rat Pineal Gland. Endocrinology. 2016;157:2028-40 pubmed publisher
    ..gland, marked cell-to-cell differences were found in ASMT immunostaining intensity and in the abundance of Tph1, Aanat, and Asmt transcripts...
  30. Byeon Y, Back K. Melatonin production in Escherichia coli by dual expression of serotonin N-acetyltransferase and caffeic acid O-methyltransferase. Appl Microbiol Biotechnol. 2016;100:6683-6691 pubmed publisher
    ..First, serotonin N-acetyltransferase (SNAT) catalyzes serotonin to N-acetylserotonin (NAS) followed by the action of N-acetylserotonin O-methyltransferase (..
  31. Kagawa S, Nishii R, Higashi T, Yamauchi H, Ogawa E, Okudaira H, et al. Relationship between [14C]MeAIB uptake and amino acid transporter family gene expression levels or proliferative activity in a pilot study in human carcinoma cells: Comparison with [3H]methionine uptake. Nucl Med Biol. 2017;49:8-15 pubmed publisher
    ..In contrast, [14C]MeAIB uptake strongly correlated with total system A amino acid transporter (SNAT) expression and proliferative activity in this preliminary study using four human carcinoma cell lines...
  32. Benabou M, Rolland T, Leblond C, Millot G, Huguet G, Delorme R, et al. Heritability of the melatonin synthesis variability in autism spectrum disorders. Sci Rep. 2017;7:17746 pubmed publisher
    ..NAS) and plasma melatonin levels, as well as the two enzymes arylalkylamine N-acetyltransferase (AANAT) and acetylserotonin O-methyltransferase (ASMT) activities measured in platelets...
  33. Ashton A, Stoney P, Ransom J, McCaffery P. Rhythmic Diurnal Synthesis and Signaling of Retinoic Acid in the Rat Pineal Gland and Its Action to Rapidly Downregulate ERK Phosphorylation. Mol Neurobiol. 2018;: pubmed publisher
    ..Its involvement in two key molecular rhythms in this gland was also examined: kinase activation and induction of Aanat, which encodes the rhythm-generating melatonin synthetic enzyme...
  34. Palner M, Shen B, Jeon J, Lin J, Chin F, Rao J. Preclinical Kinetic Analysis of the Caspase-3/7 PET Tracer 18F-C-SNAT: Quantifying the Changes in Blood Flow and Tumor Retention After Chemotherapy. J Nucl Med. 2015;56:1415-21 pubmed publisher
    ..We recently developed a novel apoptosis imaging tracer, (18)F-C-SNAT (C-SNAT is caspase-sensitive nanoaggregation tracer), that undergoes an intramolecular cyclization reaction after ..
  35. Kim H, Paik M, Lee Y, Lee Y, Choi H, Pack J, et al. Eight hours of nocturnal 915 MHz radiofrequency identification (RFID) exposure reduces urinary levels of melatonin and its metabolite via pineal arylalkylamine N-acetyltransferase activity in male rats. Int J Radiat Biol. 2015;91:898-907 pubmed publisher
    ..identification (RFID) on melatonin biosynthesis and the activity of rat pineal arylalkylamine N-acetyltransferase (AANAT)...
  36. Back K, Tan D, Reiter R. Melatonin biosynthesis in plants: multiple pathways catalyze tryptophan to melatonin in the cytoplasm or chloroplasts. J Pineal Res. 2016;61:426-437 pubmed publisher
    ..Melatonin biosynthesis from tryptophan requires four-step reactions. However, six genes, that is, TDC, TPH, T5H, SNAT, ASMT, and COMT, have been implicated in the synthesis of melatonin in plants, suggesting the presence of multiple ..
  37. Luengtrakoon K, Wannakasemsuk W, Vichitrananda V, Klanrit P, Hormdee D, Noisombut R, et al. Increased melatonin in oral mucosal tissue of oral lichen planus (OLP) patients: A possible link between melatonin and its role in oral mucosal inflammation. Arch Oral Biol. 2017;78:13-19 pubmed publisher
    ..and the semiquantitative scoring system was used to assess the levels of arylalkylamine-N-acetyltransferase (AANAT: a rate-limiting enzyme in the biosynthesis pathway of melatonin), melatonin, and melatonin receptor 1 (MT1) in ..
  38. Magoteaux S, Gilbert M, Langlais C, Garcia Filion P, Notrica D. Should Children with Suspected Nonaccidental Injury Be Admitted to a Surgical Service?. J Am Coll Surg. 2016;222:838-43 pubmed publisher
    In many hospitals, children with suspected nonaccidental trauma (sNAT) are admitted to nonsurgical services (NSS)...
  39. Adamska I, Marhelava K, Walkiewicz D, Kedzierska U, Markowska M, Majewski P. All genes encoding enzymes participating in melatonin biosynthesis in the chicken pineal gland are transcribed rhythmically. J Physiol Pharmacol. 2016;67:521-530 pubmed
    ..involved in pineal melatonin biosynthesis, tryptophan hydroxylase 1 (Tph1), arylalkylamine-N-acetyltransferase (Aanat) and acetylserotonin O-methyltransferase (Asmt), are transcribed rhythmically under light:dark (L:D) 12:12 ..
  40. Noh M, Koo B, Kramer K, Muthukrishnan S, Arakane Y. Arylalkylamine N-acetyltransferase 1 gene (TcAANAT1) is required for cuticle morphology and pigmentation of the adult red flour beetle, Tribolium castaneum. Insect Biochem Mol Biol. 2016;79:119-129 pubmed publisher
    ..insect cuticle tanning pathway (sclerotization and pigmentation), the enzyme arylalkylamine N-acetyltransferase (AANAT) catalyzes the acetylation of dopamine to form N-acetyldopamine (NADA), which is one of the major precursors for ..
  41. da Silveira Cruz Machado S, Tamura E, Carvalho Sousa C, Rocha V, Pinato L, Fernandes P, et al. Daily corticosterone rhythm modulates pineal function through NF?B-related gene transcriptional program. Sci Rep. 2017;7:2091 pubmed publisher
    ..that the rhythm of corticosterone modulates pineal phenotype, as mifepristone also reduces the expression of Aanat and the nocturnal synthesis of melatonin...
  42. Wu N, Meng F, Zhou T, Han Y, Kennedy L, Venter J, et al. Prolonged darkness reduces liver fibrosis in a mouse model of primary sclerosing cholangitis by miR-200b down-regulation. FASEB J. 2017;31:4305-4324 pubmed publisher
    ..After overexpression of arylalkylamine N-acetyltransferase (AANAT; the enzyme regulating melatonin synthesis) or inhibition of miR-200b in cholangiocytes and hepatic stellate cells ..
  43. Shi H, Wei Y, He C. Melatonin-induced CBF/DREB1s are essential for diurnal change of disease resistance and CCA1 expression in Arabidopsis. Plant Physiol Biochem. 2016;100:150-155 pubmed publisher
    ..data, we found that the transcript levels of two melatonin synthesis genes (serotonin N-acetyltransferase (SNAT) and caffeate O-methyltransferase (COMT)) and endogenous melatonin level were regulated by diurnal cycles, with ..
  44. Deng Y, Lv L, Yang G, Sui Y. [Role of serotoninergic/melatoninergic system in melanin metabolism in melanocytes exposed to serum of rabbits fed with Liuwei Dihuang decoction]. Nan Fang Yi Ke Da Xue Xue Bao. 2016;36:1401-1405 pubmed
    ..01). Exposure of the cells to low and moderate doses of the serum caused a dose-dependent decrease in AANAT activity (P<0...
  45. Leke R, Schousboe A. The Glutamine Transporters and Their Role in the Glutamate/GABA-Glutamine Cycle. Adv Neurobiol. 2016;13:223-257 pubmed
    ..responsible for glutamine efflux from astrocytes and influx into the neurons, such as the members of the SNAT, LAT, y+LAT, and ASC families of transporters...
  46. Yang Y, Sun B, Huang J, Xu L, Pan J, Fang C, et al. Up-regulation of miR-325-3p suppresses pineal aralkylamine N-acetyltransferase (Aanat) after neonatal hypoxia-ischemia brain injury in rats. Brain Res. 2017;1668:28-35 pubmed publisher
    ..Here, we first verified that mRNA and protein expression of pineal aralkylamine N-acetyltransferase (Aanat), a key regulator for melatonin (MT) synthesis, along with MT, were severely impaired after HIBD...
  47. Casado J, Iñigo Chaves A, Jiménez Ruiz S, Ríos Arrabal S, Carazo Gallego Ã, González Puga C, et al. AA-NAT, MT1 and MT2 Correlates with Cancer Stem-Like Cell Markers in Colorectal Cancer: Study of the Influence of Stage and p53 Status of Tumors. Int J Mol Sci. 2017;18: pubmed publisher
    ..Patients with CD44highCD66chigh and wtp53 tumors in advanced stages showed low expression of AA-NAT and MT2 in wtp53 tumors. These results could indicate a possible interaction of these pathways in CRC. ..
  48. Pan Q, Zhao F, Ye B. Eis, a novel family of arylalkylamine N-acetyltransferase (EC 2.3.1.87). Sci Rep. 2018;8:2435 pubmed publisher
    ..an unprecedented ability to acetylate many arylalkylamines, are a novel type of arylalkylamine N-acetyltransferase AANAT (EC 2.3.1.87)...
  49. Muxel S, Pires Lapa M, Monteiro A, Cecon E, Tamura E, Floeter Winter L, et al. NF-κB drives the synthesis of melatonin in RAW 264.7 macrophages by inducing the transcription of the arylalkylamine-N-acetyltransferase (AA-NAT) gene. PLoS ONE. 2012;7:e52010 pubmed publisher
  50. Sheshadri S, Nishanth M, Yamine V, Simon B. Effect of Melatonin on the stability and expression of reference genes in Catharanthus roseus. Sci Rep. 2018;8:2222 pubmed publisher
    ..stable reference-gene pairs was demonstrated by assessing the transcript levels of the Melatonin-biosynthesis gene SNAT under same conditions...
  51. Soria V, Martínez Amorós E, Escaramis G, Valero J, Crespo J, Gutierrez Zotes A, et al. Resequencing and association analysis of arylalkylamine N-acetyltransferase (AANAT) gene and its contribution to major depression susceptibility. J Pineal Res. 2010;49:35-44 pubmed publisher
    ..Arylalkylamine N-acetyltransferase (AANAT) is a key enzyme of the melatonin pathway involved in circadian oscillations of melatonin levels...
  52. Smith T. Phylogenetic distribution and function of arylalkylamine N-acetyltransferase. Bioessays. 1990;12:30-3 pubmed
    ..In insects, this enzyme is involved in monoamine neurotransmitter inactivation and the formation of catecholamine intermediates necessary for sclerotization of the insect cuticle. ..
  53. Obsil T, Ghirlando R, Klein D, Ganguly S, Dyda F. Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation. Cell. 2001;105:257-67 pubmed
    Serotonin N-acetyltransferase (AANAT) controls the daily rhythm in melatonin synthesis. When isolated from tissue, AANAT copurifies with isoforms epsilon and zeta of 14-3-3...
  54. Ganguly S, Gastel J, Weller J, Schwartz C, Jaffe H, Namboodiri M, et al. Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. Proc Natl Acad Sci U S A. 2001;98:8083-8 pubmed
    ..by cAMP through actions on the penultimate enzyme in melatonin synthesis, arylalkylamine N-acetyltransferase (AANAT; serotonin N-acetyltransferase, EC )...
  55. Wu F, Lee Y, Chen D, Kuo H. Association of DNA-protein crosslinks and breast cancer. Mutat Res. 2002;501:69-78 pubmed
    ..Our data suggest that the DPC method is a useful tool for detecting DNA damage, and DPC formation may be associated with the induction of breast cancer. ..
  56. Pereira D, Pedrazzoli M, Koike B, Louzada F, Benedito Silva A, Lopez A, et al. The G619A Aa-nat gene polymorphism does not contribute to sleep time variation in the Brazilian population. Behav Genet. 2007;37:637-8 pubmed
    ..frequencies of the 619A allele of the G619A Aa-nat gene polymorphism in a sample of Delayed Sleep Phase Syndrome (DSPS) patients...
  57. Mansour H, Talkowski M, Wood J, Chowdari K, McClain L, Prasad K, et al. Association study of 21 circadian genes with bipolar I disorder, schizoaffective disorder, and schizophrenia. Bipolar Disord. 2009;11:701-10 pubmed publisher
    ..5. Additional analyses using adequately powered samples are warranted to further evaluate these results. ..
  58. Kang K, Lee K, Park S, Kim Y, Back K. Enhanced production of melatonin by ectopic overexpression of human serotonin N-acetyltransferase plays a role in cold resistance in transgenic rice seedlings. J Pineal Res. 2010;49:176-82 pubmed publisher
    ..Finally, the transgenic rice seedlings with high levels of melatonin showed elevated chlorophyll synthesis during cold stress, suggesting a role for melatonin in cold-stress resistance. ..
  59. Shimozuma M, Tokuyama R, Tatehara S, Umeki H, Ide S, Mishima K, et al. Expression and cellular localizaion of melatonin-synthesizing enzymes in rat and human salivary glands. Histochem Cell Biol. 2011;135:389-96 pubmed publisher
    ..by various extrapineal organs, tissues and cells and its synthesizing enzyme arylalkylamine N-acetyltransferase (AANAT) is expressed in various extrapineal organs, tissues and cells...
  60. Liu J, Lemonds T, Marden J, Popadić A. A Pathway Analysis of Melanin Patterning in a Hemimetabolous Insect. Genetics. 2016;203:403-13 pubmed publisher
    ..Here we provide a comprehensive analysis of how a set of melanin genes (ebony, black, aaNAT, yellow, and tan) contributes to the pigmentation pattern in a hemipteran, Oncopeltus fasciatus For all five genes,..
  61. Coon S, Roseboom P, Baler R, Weller J, Namboodiri M, Koonin E, et al. Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis. Science. 1995;270:1681-3 pubmed
    ..The night-to-day ratio of ovine pineal AA-NAT mRNA is less than 2. In contrast, the ratio exceeds 150 in rats. AA-NAT represents a family within a large superfamily of acetyltransferases. ..
  62. Klein D. Arylalkylamine N-acetyltransferase: "the Timezyme". J Biol Chem. 2007;282:4233-7 pubmed publisher
    ..This activates the enzyme and prevents proteosomal proteolysis. The conserved features of regulatory systems that control arylalkylamine N-acetyltransferase are a circadian clock and environmental lighting...
  63. Wang H, Wu Z, Zhuang Q, Fei Q, Zhang J, Liu Y, et al. Association study of tryptophan hydroxylase 1 and arylalkylamine N-acetyltransferase polymorphisms with adolescent idiopathic scoliosis in Han Chinese. Spine (Phila Pa 1976). 2008;33:2199-203 pubmed publisher
    A genetic association study of tryptophan hydroxylase 1 gene (TPH1) and arylalkylamine N-acetyltransferase gene(AANAT) with adolescent idiopathic scoliosis (AIS) in Han Chinese...
  64. Jonsson L, Ljunggren E, Bremer A, Pedersen C, Landen M, Thuresson K, et al. Mutation screening of melatonin-related genes in patients with autism spectrum disorders. BMC Med Genomics. 2010;3:10 pubmed publisher
    ..However, further studies of the novel variants identified in this study are warranted to shed light on their potential role in the pathophysiology of these disorders. ..
  65. Han Y, Demorrow S, Invernizzi P, Jing Q, Glaser S, Renzi A, et al. Melatonin exerts by an autocrine loop antiproliferative effects in cholangiocarcinoma: its synthesis is reduced favoring cholangiocarcinoma growth. Am J Physiol Gastrointest Liver Physiol. 2011;301:G623-33 pubmed publisher
    ..in the pineal gland and peripheral organs from serotonin by two enzymes, serotonin N-acetyltransferase (AANAT) and acetylserotonin O-methyltransferase (ASMT)...
  66. Masuoka Y, Maekawa K. Gene expression changes in the tyrosine metabolic pathway regulate caste-specific cuticular pigmentation of termites. Insect Biochem Mol Biol. 2016;74:21-31 pubmed publisher
    ..On the other hand, high expression levels of yellow and aaNAT were observed during worker and presoldier molts, respectively, but most other genes in the pathway were expressed ..
  67. Takahashi Y, Nishimura T, Maruyama T, Tomi M, Nakashima E. Contributions of system A subtypes to α-methylaminoisobutyric acid uptake by placental microvillous membranes of human and rat. Amino Acids. 2017;49:795-803 pubmed publisher
    ..Appropriate concentrations of betaine and L-arginine for subtype-selective inhibition in SNAT-overexpressing cells were identified...
  68. Gu Q, Chen Z, Yu X, Cui W, Pan J, Zhao G, et al. Melatonin confers plant tolerance against cadmium stress via the decrease of cadmium accumulation and reestablishment of microRNA-mediated redox homeostasis. Plant Sci. 2017;261:28-37 pubmed publisher
    ..The melatonin-rich transgenic Arabidopsis plants overexpressing alfalfa SNAT (a melatonin synthetic gene) exhibited more tolerance than wild-type plants under Cd conditions...
  69. Alkozi H, Pérez de Lara M, Pintor J. Melatonin synthesis in the human ciliary body triggered by TRPV4 activation: Involvement of AANAT phosphorylation. Exp Eye Res. 2017;162:1-8 pubmed publisher
    ..two enzymes, the first limiting step into the synthesis of melatonin being aralkylamine N-acetyltransferase (AANAT)...
  70. Liu L, Jiang G, Peng Z, Li Y, Li J, Zou L, et al. The effect of high fat diet on daily rhythm of the core clock genes and muscle functional genes in the skeletal muscle of Chinese soft-shelled turtle (Trionyx sinensis). Comp Biochem Physiol B Biochem Mol Biol. 2017;213:17-27 pubmed publisher
    ..we measured the daily expression levels of 17 core clock genes (Clock, Bmal1/2, NPAS2, Tim, Cry1/2, Per1/2, DBP, AANAT, NIFL3, BHLHE40, NR1D2, RORA, RORB, RORC) and 12 muscle functional genes (FBXO32, MBNL1, MSTN, Myf5, Myf6, MyoD, ..
  71. Lee H, Back K. Cadmium Disrupts Subcellular Organelles, Including Chloroplasts, Resulting in Melatonin Induction in Plants. Molecules. 2017;22: pubmed publisher
    ..In theory, the disruption of chloroplasts enabled chloroplast-expressed serotonin N-acetyltransferase (SNAT) to encounter serotonin in the cytoplasm, leading to the synthesis of N-acetylserotonin followed by ..
  72. Roseboom P, Weller J, Babila T, Aitken A, Sellers L, Moffett J, et al. Cloning and characterization of the epsilon and zeta isoforms of the 14-3-3 proteins. DNA Cell Biol. 1994;13:629-40 pubmed
    ..This investigation also revealed the epsilon isoform was present at high levels in the rat pineal gland early in development and decreased steadily thereafter and that 30-kD isoforms exhibited the inverse developmental pattern. ..
  73. Klein D, Coon S, Roseboom P, Weller J, Bernard M, Gastel J, et al. The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland. Recent Prog Horm Res. 1997;52:307-57; discussion 357-8 pubmed
    ..The variety of mechanisms that have evolved among vertebrates to achieve the same goal-a rhythm in melatonin-underlines the important role melatonin plays as the hormonal signal of environmental lighting in vertebrates. ..
  74. Hohjoh H, Takasu M, Shishikura K, Takahashi Y, Honda Y, Tokunaga K. Significant association of the arylalkylamine N-acetyltransferase ( AA-NAT) gene with delayed sleep phase syndrome. Neurogenetics. 2003;4:151-3 pubmed
    ..We studied the association between the AA-NAT gene and delayed sleep phase syndrome (DSPS)...
  75. Ying G, Lee C, Lee E. A naturally occurring -263G/C variant of the human AA-NAT gene and overnight melatonin production. Mol Genet Metab. 2004;81:65-9 pubmed
    ..The overnight urinary 6-hydroxymelatonin sulfate (6-OHMS) excretion was quantified by enzyme-linked immunosorbent assay (ELISA). ..
  76. Wadas B, Borjigin J, Huang Z, Oh J, Hwang C, Varshavsky A. Degradation of Serotonin N-Acetyltransferase, a Circadian Regulator, by the N-end Rule Pathway. J Biol Chem. 2016;291:17178-96 pubmed publisher
    Serotonin N-acetyltransferase (AANAT) converts serotonin to N-acetylserotonin (NAS), a distinct biological regulator and the immediate precursor of melatonin, a circulating hormone that influences circadian processes, including sleep...
  77. Achterberg M, van Duijvenvoorde A, Van der Meulen M, Euser S, Bakermans Kranenburg M, Crone E. The neural and behavioral correlates of social evaluation in childhood. Dev Cogn Neurosci. 2017;24:107-117 pubmed publisher
    ..of social feedback and subsequent aggression in 7-10-year-old children, using the Social Network Aggression Task (SNAT)...
  78. Alkozi H, Pérez de Lara M, Sánchez Navés J, Pintor J. TRPV4 Stimulation Induced Melatonin Secretion by Increasing Arylalkymine N-acetyltransferase (AANAT) Protein Level. Int J Mol Sci. 2017;18: pubmed publisher
    ..from serotonin in two steps, with a rate-limiting step carried out by arylalkymine N-acetyltransferase (AANAT)...
  79. Sijbesma E, Skora L, Leysen S, Brunsveld L, Koch U, Nussbaumer P, et al. Identification of Two Secondary Ligand Binding Sites in 14-3-3 Proteins Using Fragment Screening. Biochemistry. 2017;56:3972-3982 pubmed publisher
    ..This first identification of secondary sites on 14-3-3 proteins bound by small molecule ligands might facilitate the development of new chemical tool compounds for more selective PPI modulation. ..
  80. Gu F, Zhang H, Hyland P, Berndt S, Gapstur S, Wheeler W, et al. Inherited variation in circadian rhythm genes and risks of prostate cancer and three other cancer sites in combined cancer consortia. Int J Cancer. 2017;141:1794-1802 pubmed publisher
    ..00625). The two most significant genes were NPAS2 (pgene ?=?0.0062) and AANAT (pgene ?=?0.00078); the latter being significant after Bonferroni correction...
  81. Coon S, Weller J, Korf H, Namboodiri M, Rollag M, Klein D. cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation. J Biol Chem. 2001;276:24097-107 pubmed
    Arylalkylamine N-acetyltransferase (serotonin N-acetyltransferase, AANAT, EC ) is the penultimate enzyme in melatonin synthesis...
  82. Sekine A, Saito S, Iida A, Mitsunobu Y, Higuchi S, Harigae S, et al. Identification of single-nucleotide polymorphisms (SNPs) of human N-acetyltransferase genes NAT1, NAT2, AANAT, ARD1 and L1CAM in the Japanese population. J Hum Genet. 2001;46:314-9 pubmed
    ..arylamine N-acetyltransferase (NAT1), arylamine N-acetyltransferase (NAT2), arylalkylamine N-acetyltransferase (AANAT), L1 cell adhesion molecule (L1CAM), and the human homolog of Saccharomyces cerevisiae N-acetyltransferase ARD1, ..
  83. Blomeke B, Golka K, Griefahn B, Roemer H. Arylalkylamine N-acetyltransferase (AANAT) genotype as a personal trait in melatonin synthesis. J Toxicol Environ Health A. 2008;71:874-6 pubmed publisher
    ..quot; Arylalkylamine N-acetyltransferase (AANAT) is known to catalyze the acetylation of serotonin, a rate-limiting process in melatonin synthesis...
  84. Anderson B, Schnetz Boutaud N, Bartlett J, Wotawa A, Wright H, Abramson R, et al. Examination of association of genes in the serotonin system to autism. Neurogenetics. 2009;10:209-16 pubmed publisher
    ..These data suggest that variation within genes on the serotonin pathway, particularly HTR3A, may have modest effects on autism risk. ..
  85. Markowska M, Majewski P, Skwarło Sońta K. Avian biological clock - Immune system relationship. Dev Comp Immunol. 2017;66:130-138 pubmed publisher
    ..production at the level of the key enzyme in its biosynthetic pathway, arylalkylamine-N-acetyltransferase (AANAT)...
  86. Alkozi H, Wang X, Pérez de Lara M, Pintor J. Presence of melanopsin in human crystalline lens epithelial cells and its role in melatonin synthesis. Exp Eye Res. 2017;154:168-176 pubmed publisher
    ..Moreover, studying the concentration of melatonin and its synthesising enzyme AANAT proved a clear link between melanopsin activation and the suppression of melatonin synthesis...
  87. Huang Y, Liu S, Yuan S, Guan C, Tian D, Cui X, et al. Overexpression of ovine AANAT and HIOMT genes in switchgrass leads to improved growth performance and salt-tolerance. Sci Rep. 2017;7:12212 pubmed publisher
    ..Our study provided valuable findings that melatonin functions as a promoter in the regulation of switchgrass growth, flowering and salt tolerance. ..
  88. Kirsz K, Szczesna M, Molik E, Zieba D. Effects of ghrelin on nocturnal melatonin secretion in sheep: An in vitro and in vivo approach. J Anim Sci. 2017;95:4101-4112 pubmed publisher
    ..These findings indicate that GHRL directly and indirectly affects PG activity in sheep and that the photoperiod modulates the effects of GHRL...
  89. Chapman E, O Dell A, Meligi N, Parsons D, Rotchell J. Seasonal expression patterns of clock-associated genes in the blue mussel Mytilus edulis. Chronobiol Int. 2017;:1-15 pubmed publisher
    ..edulis), using mRNA expression patterns of clock-associated genes: Clock, Cry1¸ ARNT, Timeout-like, ROR/HR3 and aaNAT, in the gonads of both sexes, sampled over three daily time-points on a tidal beach during the winter and summer ..
  90. Lee K, Lee H, Back K. Rice histone deacetylase 10 and Arabidopsis histone deacetylase 14 genes encode N-acetylserotonin deacetylase, which catalyzes conversion of N-acetylserotonin into serotonin, a reverse reaction for melatonin biosynthesis in plants. J Pineal Res. 2017;: pubmed publisher
    ..present in archaea, but not in cyanobacteria, which differs from the distribution of serotonin N-acetyltransferase (SNAT). This suggests that SNAT and ASDAC may have evolved differently from ancestral eukaryotic cells...
  91. Slominski A, Pisarchik A, Semak I, Sweatman T, Wortsman J, Szczesniewski A, et al. Serotoninergic and melatoninergic systems are fully expressed in human skin. FASEB J. 2002;16:896-8 pubmed
    ..showed simultaneous expression of the genes for tryptophan hydroxylase, arylalkylamine N-acetyltransferase (AANAT), and hydroxyindole-O-methyltransferase (HIOMT)...
  92. Wang G, Lee C, Lee E. Genetic variability of arylalkylamine-N-acetyl-transferase (AA-NAT) gene and human sleep/wake pattern. Chronobiol Int. 2004;21:229-37 pubmed
    ..The -263G/C SNP may therefore be an important determinant of the late/short sleep pattern. ..