AADAC

Summary

Gene Symbol: AADAC
Description: arylacetamide deacetylase
Alias: CES5A1, DAC, arylacetamide deacetylase, arylacetamide deacetylase (esterase)
Species: human
Products:     AADAC

Top Publications

  1. Szarc vel Szic K, Declerck K, Crans R, Diddens J, Scherf D, Gerhäuser C, et al. Epigenetic silencing of triple negative breast cancer hallmarks by Withaferin A. Oncotarget. 2017;8:40434-40453 pubmed publisher
    ..In contrast to the DNA demethylating agent 5-aza-2'-deoxycytidine (DAC), WA treatment of MDA-MB-231 cells rather tackles an epigenetic cancer network through gene-specific DNA ..
  2. Doody E, Groebner J, Walker J, Frizol B, Tuma D, Fernandez D, et al. Ethanol metabolism by alcohol dehydrogenase or cytochrome P450 2E1 differentially impairs hepatic protein trafficking and growth hormone signaling. Am J Physiol Gastrointest Liver Physiol. 2017;313:G558-G569 pubmed publisher
  3. Quiroga A, Lehner R. Pharmacological intervention of liver triacylglycerol lipolysis: The good, the bad and the ugly. Biochem Pharmacol. 2018;155:233-241 pubmed publisher
    ..phospholipase domain containing 3 (PNPLA3), some members of the carboxylesterase family (CES/Ces), arylacetamide deacetylase (AADAC), lysosomal acid lipase (LAL) and hepatic lipase (HL)...
  4. Chandel N, Ayasolla K, Lan X, Sultana Syed M, Chawla A, Lederman R, et al. Epigenetic Modulation of Human Podocyte Vitamin D Receptor in HIV Milieu. J Mol Biol. 2015;427:3201-3215 pubmed publisher
    ..Neither a VDR agonist (VDA) nor an HDAC inhibitor (HDACI) nor a demethylating agent (DAC) individually could optimally up regulate VDR in HIV milieu...
  5. Pham Thi K, Briant L, Gavotte L, Labbé P, Perriat Sanguinet M, Cornillot E, et al. Incidence of dengue and chikungunya viruses in mosquitoes and human patients in border provinces of Vietnam. Parasit Vectors. 2017;10:556 pubmed publisher
    ..The highest incidence was found in Dac Nong Province, where the Breteau and Container indices were the second lowest...
  6. Fojo T, Bates S. Strategies for reversing drug resistance. Oncogene. 2003;22:7512-23 pubmed
    ..re-expressing genes, including genes that affect drug sensitivity, using 5-azacytidine and 2'-deoxy-5-azacytidine (DAC, decitabine) as demethylating agents...
  7. Lu D, Dong D, Liu Z, Wang Y, Wu B. Metabolism elucidation of BJ-B11 (a heat shock protein 90 inhibitor) by human liver microsomes: identification of main contributing enzymes. Expert Opin Drug Metab Toxicol. 2015;11:1029-40 pubmed publisher
    ..Hydrolysis of BJ-B11 was markedly inhibited by vinblastine (a dual inhibitor of arylacetamide deacetylase and carboxylesterase 2)...
  8. Pandey N, Goswami N, Tripathi D, Rai K, Rai S, Singh S, et al. Epigenetic control of UV-B-induced flavonoid accumulation in Artemisia annua L. Planta. 2018;: pubmed publisher
    ..accumulation of total flavonoid and phenolics content as well as eleven individual flavonoids measured through HPLC-DAC. Expression of eight genes (phenylanaline ammonia lyase, cinnamate-4-hydroxylase, 4-coumarate: CoA ligase; chalcone ..
  9. Sidler M, Aitken K, Jiang J, Sotiropoulos C, Aggarwal P, Anees A, et al. DNA Methylation Reduces the Yes-Associated Protein 1/WW Domain Containing Transcription Regulator 1 Pathway and Prevents Pathologic Remodeling during Bladder Obstruction by Limiting Expression of BDNF. Am J Pathol. 2018;188:2177-2194 pubmed publisher
    ..After 2 weeks, rats were randomized to normal saline or DNA methyltransferase inhibitor, 5-aza-2-deoxycytidine (DAC) at 1 mg/kg, three times/week intraperitoneally...

More Information

Publications135 found, 100 shown here

  1. Wolff F, Leisch M, Greil R, Risch A, Pleyer L. The double-edged sword of (re)expression of genes by hypomethylating agents: from viral mimicry to exploitation as priming agents for targeted immune checkpoint modulation. Cell Commun Signal. 2017;15:13 pubmed publisher
    ..Recent investigations into the mode of action of azacitidine (AZA) and decitabine (DAC) have revealed new molecular mechanisms that impinge on tumor immunity via induction of an interferon response, ..
  2. Varol N, Konac E, Bilen C. Does Wnt/β-catenin pathway contribute to the stability of DNMT1 expression in urological cancer cell lines?. Exp Biol Med (Maywood). 2015;240:624-30 pubmed publisher
    ..levels of DNMT1, β-catenin, HAUSP, and UHRF1 decreased after re-expression of WIF-1 following treatment with DAC. In Caki-2 cells, β-catenin pathway might have accounted for the stability of DNMT1 expression, whereas such ..
  3. Klar A, Gopinadh J, Kleber S, Wadle A, Renner C. Treatment with 5-Aza-2'-Deoxycytidine Induces Expression of NY-ESO-1 and Facilitates Cytotoxic T Lymphocyte-Mediated Tumor Cell Killing. PLoS ONE. 2015;10:e0139221 pubmed publisher
    ..for up-regulation of NY-ESO-1 expression by tumor cells using the hypomethylating agent 5-aza-2'-deoxycytidine (DAC)...
  4. Liu S, Liu F, Huang W, Gu L, Meng L, Ju Y, et al. MAGE-A11 is activated through TFCP2/ZEB1 binding sites de-methylation as well as histone modification and facilitates ESCC tumor growth. Oncotarget. 2018;9:3365-3378 pubmed publisher
    ..HDAC inhibitor Trichostatin A (TSA) increased DNA methylase inhibitor Decitabine (DAC)-induced MAGE-A11 expression...
  5. Anders N, Liu J, Wanjiku T, Giovinazzo H, Zhou J, Vaghasia A, et al. Simultaneous quantitative determination of 5-aza-2'-deoxycytidine genomic incorporation and DNA demethylation by liquid chromatography tandem mass spectrometry as exposure-response measures of nucleoside analog DNA methyltransferase inhibitors. J Chromatogr B Analyt Technol Biomed Life Sci. 2016;1022:38-45 pubmed publisher
    ..activities of the nucleoside analog DNA methyltransferase (DNMT) inhibitors decitabine (5-aza-2'-deoxycytidine, DAC), azacitidine, and guadecitabine are thought to require cellular uptake, metabolism to 5-aza-2'-deoxycytidine ..
  6. Yetişir F, Sarer A, Acar H, Yazıcıoglu O, Basaran B. Treatment of delayed jejunal perforation after irreducible femoral hernia repair with open abdomen management and delayed abdominal closure with skin flap approximation. Int J Surg Case Rep. 2015;16:19-24 pubmed publisher
    ..femoral hernia operation with the help of negative pressure therapy (NPT) and delayed abdominal closure (DAC) with skin flap approximation in an elderly woman for the first time in the literature...
  7. Takayama T, Tsutsui H, Shimizu I, Toyama T, Yoshimoto N, Endo Y, et al. Diagnostic approach to breast cancer patients based on target metabolomics in saliva by liquid chromatography with tandem mass spectrometry. Clin Chim Acta. 2016;452:18-26 pubmed publisher
    ..The discriminant analysis using 6 polyamines (i.e., N8-Ac-SPD, N1-Ac-SPD, CAD, DAc-SPD, PUT, and Ac-PUT), which were the most influenced molecules derived from the ROC analysis, was performed using ..
  8. Xu W, Huang Y, Xiao H. [Expression Analysis and Epigenetics of MicroRNA let-7b in Acute Lymphoblastic Leukemia]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2015;23:1535-41 pubmed publisher
    ..to detect the expression levels of microRNA let-7b in this 2 groups; and then 5-aza-2'-deoxycytidine (5-Aza-dC, DAC) was used to treat ALL cell line MOLT-4; after drug treatment, MSP was used to analyze the methylation status of ..
  9. Gotoh H, Zinna R, Ishikawa Y, Miyakawa H, Ishikawa A, Sugime Y, et al. The function of appendage patterning genes in mandible development of the sexually dimorphic stag beetle. Dev Biol. 2017;422:24-32 pubmed publisher
    ..Tribolium studies, we focused on seven appendage patterning genes (Distal-less (Dll), aristaless (al), dachshund (dac), homothorax (hth), Epidermal growth factor receptor (Egfr), escargot (esg), and Keren (Krn)...
  10. Pasini A, Brand O, Jenkins G, Knox A, Pang L. Suberanilohydroxamic acid prevents TGF-?1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation. Biochim Biophys Acta Gene Regul Mech. 2018;1861:463-472 pubmed publisher
    ..inhibitor suberanilohydroxamic acid (SAHA) and to a lesser extent by the DNA demethylating agent Decitabine (DAC), but not by the G9a histone methyltransferase (HMT) inhibitor BIX01294 or the EZH2 HMT inhibitor 3-deazaneplanocin ..
  11. Yamasaki T, Fujinaga M, Mori W, Zhang Y, Wakizaka H, Nengaki N, et al. In Vivo Monitoring for Regional Changes of Metabotropic Glutamate Receptor Subtype 1 (mGluR1) in Pilocarpine-Induced Epileptic Rat Brain by Small-Animal PET. Sci Rep. 2017;7:14945 pubmed publisher
    ..N-benzyl-N-[11C]methyl-2-(7-methyl-8-oxo-2-phenyl-7,8-dihydro-9H-purin-9-yl)acetamide ([11C]DAC), a selective translocator protein PET ligand for neuroinflammation monitoring...
  12. Salcedo M, Prieto M, Castells L, Pascasio J, Montero Alvarez J, Fernandez I, et al. Efficacy and safety of daclatasvir-based antiviral therapy in hepatitis C virus recurrence after liver transplantation. Role of cirrhosis and genotype 3. A multicenter cohort study. Transpl Int. 2017;30:1041-1050 pubmed publisher
    ..We evaluated the efficacy, predictors of survival, and safety of DAC-based regimens in a large real-world cohort. A total of 331 patients received DCV-based therapy...
  13. Shen H, Li W, Tian Y, Xu P, Wang H, Zhang J, et al. Upregulation of miR-362-3p Modulates Proliferation and Anchorage-Independent Growth by Directly Targeting Tob2 in Hepatocellular Carcinoma. J Cell Biochem. 2015;116:1563-73 pubmed publisher
    ..carcinoma (HCC) cell lines and two normal immortalized cell lines treated with 5-Aza-2'-deoxycytidine (DAC, an inhibitor of DNA methylation) plus TSA (Trichostatin A, histone deacetylase inhibitor)...
  14. Bando T, Mito T, Hamada Y, Ishimaru Y, Noji S, Ohuchi H. Molecular mechanisms of limb regeneration: insights from regenerating legs of the cricket Gryllus bimaculatus. Int J Dev Biol. 2018;62:559-569 pubmed publisher
    ..Downstream targets of this pathway are transcription factors Distal-less (Dll) and dachshund (dac), functioning as key regulators of proximodistal pattern formation...
  15. Guzeldemir Akcakanat E, Sunnetci Akkoyunlu D, Orucguney B, Cine N, Kan B, Yılmaz E, et al. Gene-Expression Profiles in Generalized Aggressive Periodontitis: A Gene Network-Based Microarray Analysis. J Periodontol. 2016;87:58-65 pubmed publisher
    ..IGLL5, MMP7, SPAG4, and MEI1; the most downregulated genes were found as LOR, LAMB4, AADACL2, MAPT, ARG1, NPR3, AADAC, DSC1, LRRC4, and CHP2...
  16. Xu D, Du M, Zhang J, Xiong P, Li W, Zhang H, et al. DNMT1 mediated promoter methylation of GNAO1 in hepatoma carcinoma cells. Gene. 2018;665:67-73 pubmed publisher
    ..Moreover, 5-Aza-2'-deoxycytidine (DAC) with Trichostatin A (TSA) treatment made it much clear that GNAO1 transcription was inhibited by promoter ..
  17. Commichau F, Heidemann J, Ficner R, Stülke J. Making and breaking of an essential poison: the cyclases and phosphodiesterases that produce and degrade the essential second messenger cyclic di-AMP in bacteria. J Bacteriol. 2018;: pubmed publisher
    ..In the diadenylate cyclases, one type of catalytic domain, the DAC domain, is coupled to various other domains that control the localization, the protein-protein interactions, and ..
  18. Hong C, Siddiqui A, Sabljic T, Ball A. Changes in parvalbumin immunoreactive retinal ganglion cells and amacrine cells after optic nerve injury. Exp Eye Res. 2016;145:363-372 pubmed publisher
    ..There was no change in PARV AC or dAC number or staining intensity...
  19. Ingebrigtsen S, Skalko Basnet N, de Albuquerque Cavalcanti Jacobsen C, Holsæter A. Successful co-encapsulation of benzoyl peroxide and chloramphenicol in liposomes by a novel manufacturing method - dual asymmetric centrifugation. Eur J Pharm Sci. 2017;97:192-199 pubmed publisher
    ..chloramphenicol (CAM) into liposomes using the novel liposome processing method - dual asymmetric centrifugation (DAC)...
  20. Carneiro L, de Lucena E, Sampaio C, Dantas A, Sousa W, Santos M, et al. Internal dosimetry of nuclear medicine workers through the analysis of (131)I in aerosols. Appl Radiat Isot. 2015;100:70-4 pubmed publisher
    ..4Bq/m(3). This value is about three orders of magnitude below the Derived Air Concentration (DAC) of 8.4kBq/m(3)...
  21. Vergnolle O, Xu H, Tufariello J, Favrot L, Malek A, Jacobs W, et al. Post-translational Acetylation of MbtA Modulates Mycobacterial Siderophore Biosynthesis. J Biol Chem. 2016;291:22315-22326 pubmed
    ..MbtA acetylation can be reversed by the NAD+-dependent DAc (deacetyltransferase), Rv1151c...
  22. Finelli C, Follo M, Stanzani M, Parisi S, Clissa C, Mongiorgi S, et al. Clinical Impact of Hypomethylating Agents in the Treatment of Myelodysplastic Syndromes. Curr Pharm Des. 2016;22:2349-57 pubmed
    ..Two drugs, azacitidine (AZA) and decitabine (DAC), defined, because of their proven mechanism of action, as DNA methyltransferase inhibitors (DNMTIs), or ..
  23. Prigge C, Yeh P, Liou N, Lee C, You S, Liu L, et al. M1 ipRGCs Influence Visual Function through Retrograde Signaling in the Retina. J Neurosci. 2016;36:7184-97 pubmed publisher
    ..DACs): (1) ipRGC signaling to DACs is blocked by tetrodotoxin both in vitro and in vivo, indicating that ipRGC-to-DAC transmission requires voltage-gated Na(+) channels; (2) this transmission is partly dependent on N-type Ca(2+) ..
  24. Ruby M, Massart J, Hunerdosse D, Schönke M, Correia J, Louie S, et al. Human Carboxylesterase 2 Reverses Obesity-Induced Diacylglycerol Accumulation and Glucose Intolerance. Cell Rep. 2017;18:636-646 pubmed publisher
    ..We identified reduced hepatic activity of carboxylesterase 2 (CES2) and arylacetamide deacetylase (AADAC) in human obesity...
  25. Li Y, Wang X, He B, Cai H, Gao Y. Downregulation and tumor-suppressive role of XPO5 in hepatocellular carcinoma. Mol Cell Biochem. 2016;415:197-205 pubmed publisher
    ..Additionally, after treatment with DAC and TSA, the mRNA level of XPO5 was upregulated in HCC cells tested, implicating that epigenetic modulation may be ..
  26. Xu H, Hao S, Zhang J, Chen Z, Wang H, Guan W. The formation and modification of chromatin-like structure of human parvovirus B19 regulate viral genome replication and RNA processing. Virus Res. 2017;232:134-138 pubmed publisher
    ..Interestingly, the inhibitor of DNA methyl-transferase (5-Aza-2'-deoxycytidine, DAC) inhibited not only the formation of chromatin-like structure, but also the replication of the viral genomic DNA...
  27. Su S, Hong F, Liang Y, Zhou J, Liang Y, Chen K, et al. Lgr5 Methylation in Cancer Stem Cell Differentiation and Prognosis-Prediction in Colorectal Cancer. PLoS ONE. 2015;10:e0143513 pubmed publisher
    ..with complete methylation observed in HCT116 cells in which the lgr5 expression was partially recovered following DAC treatment...
  28. Anand C, Garg R, Ghosh S, Nagaraja V. A Sir2 family protein Rv1151c deacetylates HU to alter its DNA binding mode in Mycobacterium tuberculosis. Biochem Biophys Res Commun. 2017;493:1204-1209 pubmed publisher
    ..Deacetylated HU (MtHUdAc) bound to relaxed DNA leading to the formation of looped and dense molecules as compared to open structures ..
  29. Rygg A, Hindle M, Longest P. Absorption and Clearance of Pharmaceutical Aerosols in the Human Nose: Effects of Nasal Spray Suspension Particle Size and Properties. Pharm Res. 2016;33:909-21 pubmed publisher
    The objective of this study was to use a recently developed nasal dissolution, absorption, and clearance (DAC) model to evaluate the extent to which suspended drug particle size influences nasal epithelial drug absorption for a spray ..
  30. Pietrucha K, Marzec E, Kudzin M. Pore structure and dielectric behaviour of the 3D collagen-DAC scaffolds designed for nerve tissue repair. Int J Biol Macromol. 2016;92:1298-1306 pubmed publisher
    ..to determine the microarchitecture and activation energy of collagen (Col) modified by 2,3 dialdehyde cellulose (DAC)...
  31. Watanabe N. High Pressure Macromolecular Crystallography. Subcell Biochem. 2015;72:677-86 pubmed publisher
    ..years, significant development in high-pressure macromolecular crystallography (HPMX) using a diamond anvil cell (DAC) has been performed in combination with shorter wavelength X-ray of synchrotron radiation...
  32. Minocha M, Tran J, Sheridan J, Othman A. Blockade of the High-Affinity Interleukin-2 Receptors with Daclizumab High-Yield Process: Pharmacokinetic/Pharmacodynamic Analysis of Single- and Multiple-Dose Phase I Trials. Clin Pharmacokinet. 2016;55:121-30 pubmed publisher
    Daclizumab high-yield process (DAC HYP) is a humanized monoclonal antibody that selectively blocks the α-subunit (CD25) of the high-affinity interleukin-2 receptors, and has shown robust efficacy as a treatment for multiple sclerosis (..
  33. Kumar A, Madden D, Lusi M, Chen K, Daniels E, Curtin T, et al. Direct Air Capture of CO2 by Physisorbent Materials. Angew Chem Int Ed Engl. 2015;54:14372-7 pubmed publisher
    Sequestration of CO2, either from gas mixtures or directly from air (direct air capture, DAC), could mitigate carbon emissions. Here five materials are investigated for their ability to adsorb CO2 directly from air and other gas mixtures...
  34. Hou Y, Wang F, Cheng L, Luo T, Xu J, Wang H. Expression Profiles of SIRT1 and APP Genes in Human Neuroblastoma SK-N-SH Cells Treated with Two Epigenetic Agents. Neurosci Bull. 2016;32:455-62 pubmed publisher
    ..of gene modulation in AD, we used two epigenetic drugs, the DNA methylation inhibitor 5-aza-2'-deoxycytidine (DAC) and the histone deacetylase inhibitor trichostatin A (TSA), to treat human neuroblastoma SK-N-SH cells in the ..
  35. Yuan L, Zheng W, Yang Z, Deng X, Song Z, Deng H. Association of the AADAC gene and Tourette syndrome in a Han Chinese cohort. Neurosci Lett. 2018;666:24-27 pubmed publisher
    ..Recently, the deletion in the arylacetamide deacetylase gene (AADAC) was reported to be associated with TS...
  36. Liu L, Stephan D. An imine-gallium Lewis pair stabilized oxophosphinidene via an unexpected phosphirene rearrangement. Chem Commun (Camb). 2018;54:1041-1044 pubmed publisher
    The reaction of a DAC-derived phosphirene 1 with AlCl3 reveals the formation of a simple donor acceptor adduct 2 of the DAC carbonyl fragments with AlCl3...
  37. Rezk M, Bendas E, Basalious E, Karim I. Development and validation of sensitive and rapid UPLC-MS/MS method for quantitative determination of daclatasvir in human plasma: Application to a bioequivalence study. J Pharm Biomed Anal. 2016;128:61-66 pubmed publisher
    A rapid and sensitive UPLC-MS/MS method was developed and validated for determination of daclatasvir (DAC) in human plasma using sofosbuvir (SOF) as an internal standard (IS)...
  38. Sakwa Novak M, Yoo C, Tan S, Rashidi F, Jones C. Poly(ethylenimine)-Functionalized Monolithic Alumina Honeycomb Adsorbents for CO2 Capture from Air. ChemSusChem. 2016;9:1859-68 pubmed publisher
    ..carbon capture and sequestration (CCS) from power plant flue gases or CO2 extraction directly from ambient air (DAC), require high flow rates of gas to be processed at low cost...
  39. Sayari A, Liu Q, Mishra P. Enhanced Adsorption Efficiency through Materials Design for Direct Air Capture over Supported Polyethylenimine. ChemSusChem. 2016;9:2796-2803 pubmed publisher
    ..Here, we describe innovative materials for direct air capture (DAC) with unprecedented efficiency...
  40. Milo R, Osherov M. Daclizumab and its use in multiple sclerosis treatment. Drugs Today (Barc). 2017;53:7-18 pubmed publisher
    ..The pharmacokinetic profile of its currently available form, daclizumab high-yield process (DAC-HYP, Zinbryta), suggests high subcutaneous bioavailability, linear pharmacokinetics and an effective half-life ..
  41. Jang J, Jung Y, Choi J, Jung H, Ryoo S. Bedaquiline susceptibility test for totally drug-resistant tuberculosis Mycobacterium tuberculosis. J Microbiol. 2017;55:483-487 pubmed publisher
    ..tuberculosis that shows resistant to all first- and second-line drugs-using an innovative disc agarose channel (DAC) system...
  42. Tanaka S, Hosokawa M, Ueda K, Iwakawa S. Effects of Decitabine on Invasion and Exosomal Expression of miR-200c and miR-141 in Oxaliplatin-Resistant Colorectal Cancer Cells. Biol Pharm Bull. 2015;38:1272-9 pubmed publisher
    The effects of decitabine (DAC), a DNA methyltransferase (DNMT) inhibitor, on metastasis and exosomal expression of microRNAs were examined in SW620/OxR cells, a human colorectal cancer (CRC) cell line (SW620) with acquired resistance to ..
  43. Gurol A, Okten Kursun A, Kasapoglu P, Süzergöz F, Küçüksezer U, Cevik A, et al. The synergistic effect of ω3 and Vit D3 on glycemia and TNF-α in islet transplantation. Cell Mol Biol (Noisy-le-grand). 2016;62:90-8 pubmed
    ..Daclizumab (DAC) was used for immunosuppression. Glycemia levels decreased in rats treated with ω3 and vit D3...
  44. Gerges S, Rohde K, Fulda S. Cotreatment with Smac mimetics and demethylating agents induces both apoptotic and necroptotic cell death pathways in acute lymphoblastic leukemia cells. Cancer Lett. 2016;375:127-132 pubmed publisher
    ..e. 5-azacytidine (5AC) or 5-aza-2'-deoxycytidine (DAC)) to induce cell death in ALL cells...
  45. Pham T, Liang Z, Marcellin E, Turner M. Replenishing the cyclic-di-AMP pool: regulation of diadenylate cyclase activity in bacteria. Curr Genet. 2016;62:731-738 pubmed
    ..The intracellular pool of c-di-AMP is maintained by the activities of diadenylate cyclase (DAC) and phosphodiesterase (PDE) enzymes, as well as possibly via c-di-AMP export...
  46. Kim U, Lee Y, Kang T, Choi J, Kimura S, Wada M. Protein adsorption of dialdehyde cellulose-crosslinked chitosan with high amino group contents. Carbohydr Polym. 2017;163:34-42 pubmed publisher
    Crosslinked chitosan was prepared by Schiff base formation between the aldehyde groups of dialdehyde cellulose (DAC) and the amino groups of chitosan and a subsequent reduction...
  47. Allen M, Freund S, Zinzalla G, Bycroft M. The SWI/SNF Subunit INI1 Contains an N-Terminal Winged Helix DNA Binding Domain that Is a Target for Mutations in Schwannomatosis. Structure. 2015;23:1344-9 pubmed publisher
    ..The domain is structurally related to the SKI/SNO/DAC domain, which is found in a number of metazoan chromatin-associated proteins.
  48. Ivanova E, Yee C, Sagdullaev B. Disruption in dopaminergic innervation during photoreceptor degeneration. J Comp Neurol. 2016;524:1208-21 pubmed publisher
    ..rd1, and rd1/C57 mice we were able to dissect the impacts of genetic background and the degenerative process on DAC structure in RD retina...
  49. Cortese I, Ohayon J, Fenton K, Lee C, Raffeld M, Cowen E, et al. Cutaneous adverse events in multiple sclerosis patients treated with daclizumab. Neurology. 2016;86:847-55 pubmed publisher
    ..of cutaneous adverse events (AEs) in patients with multiple sclerosis treated with daclizumab high-yield process (DAC-HYP)...
  50. Tyagi P, Kumar A, Gupta D, Singh H. Decorporation of Iron Metal Using Dialdehyde Cellulose-Deferoxamine Microcarrier. AAPS PharmSciTech. 2017;18:156-165 pubmed publisher
    ..Therefore, an intravenous deferoxamine delivery system based on dialdehyde cellulose (DAC) polymer was developed and its efficacy and toxicity were tested in iron-overloaded animals...
  51. He T, Wang C, Zhang M, Zhang X, Zheng S, Linghu E, et al. Epigenetic regulation of voltage-gated potassium ion channel molecule Kv1.3 in mechanisms of colorectal cancer. Discov Med. 2017;23:155-162 pubmed
    ..in RKO, DLD1, SW620, HCT116, and HT29 cells, and increased in LOVO and SW480 cells after 5-aza-2'-deoxycytidine (DAC) treatment. The results suggest that the expression of Kv1...
  52. Naushad M, Khan M, AlOthman Z, AlSohaimi I, Rodriguez Reinoso F, Turki T, et al. Removal of BrO₃⁻ from drinking water samples using newly developed agricultural waste-based activated carbon and its determination by ultra-performance liquid chromatography-mass spectrometry. Environ Sci Pollut Res Int. 2015;22:15853-65 pubmed publisher
    ..The prepared date pit-based activated carbon (DAC) was used for the removal of bromate (BrO3 (-))...
  53. Jin M, Mardon G. Distinct Biochemical Activities of Eyes absent During Drosophila Eye Development. Sci Rep. 2016;6:23228 pubmed publisher
    ..Using a genomic rescue system, we find that the PST domain is essential for Eya activity and Dac expression, and the TPM is required for full Eya function...
  54. Al Adham E, Hassan A, Hazem M, Shebl A. Evaluation of Therapeutic Effect of Rice Husk Silica Combined with Platelets Derived Growth Factor in Hepatic Veno- Occlusive Disease. Biochem Cell Biol. 2018;: pubmed publisher
    ..with a platelet-derived growth factor (PDGF) on the Veno-occlusive disease in liver (VOD) elicited by dactinomycin (DAC) in rats. Forty-eight male Sprague-Dawely rats were classified into six groups, 8 rats each...
  55. Shimizu M, Fukami T, Kobayashi Y, Takamiya M, Aoki Y, Nakajima M, et al. A novel polymorphic allele of human arylacetamide deacetylase leads to decreased enzyme activity. Drug Metab Dispos. 2012;40:1183-90 pubmed publisher
    Human arylacetamide deacetylase (AADAC) is responsible for the hydrolysis of clinically used drugs such as flutamide, phenacetin, and rifamycins...
  56. Wang L, Amoozgar Z, Huang J, Saleh M, Xing D, Orsulic S, et al. Decitabine Enhances Lymphocyte Migration and Function and Synergizes with CTLA-4 Blockade in a Murine Ovarian Cancer Model. Cancer Immunol Res. 2015;3:1030-41 pubmed publisher
    ..In this study, the antitumor effects of a related DNA methyl transferase inhibitor, decitabine (DAC), were demonstrated in a syngeneic murine ovarian cancer model...
  57. Mo Z, Huang J, Xiao D, Ashraf U, Duan M, Pan S, et al. Supplementation of 2-Ap, Zn and La Improves 2-Acetyl-1-Pyrroline Concentrations in Detached Aromatic Rice Panicles In Vitro. PLoS ONE. 2016;11:e0149523 pubmed publisher
    ..medium supplemented with 2-AP, Zn and La, and 2-AP concentrations were assessed at 7 and 14 days after culture (DAC)...
  58. Phillips G, Guo S, Bender R, Havrdova E, Proskorovsky I, Vollmer T. Assessing the impact of multiple sclerosis disease activity and daclizumab HYP treatment on patient-reported outcomes: Results from the SELECT trial. Mult Scler Relat Disord. 2016;6:66-72 pubmed publisher
    The SELECT study demonstrated superior effects of daclizumab high-yield process (DAC HYP) to placebo in key endpoints in patients with relapsing and remitting multiple sclerosis (RRMS)...
  59. Kraft K, Massey E, Kolb D, Walldorf U, Urbach R. Retinal homeobox promotes cell growth, proliferation and survival of mushroom body neuroblasts in the Drosophila brain. Mech Dev. 2016;142:50-61 pubmed publisher
    ..Prospero (Pros), and does not regulate the expression of other key regulators of MB development, Eyeless (Ey) and Dachshund (Dac). Our data support that the role of Rx in forebrain development is conserved between vertebrates and fly.
  60. Shi S, Collins L, Mahon M, Djurovich P, Thompson M, Whittlesey M. Synthesis and characterization of phosphorescent two-coordinate copper(i) complexes bearing diamidocarbene ligands. Dalton Trans. 2017;46:745-752 pubmed publisher
    The photophysical properties of four, two-coordinate, linear diamidocarbene copper(i) complexes, [(DAC)2Cu][BF4] (1), (DAC)CuOSiPh3 (2), (DAC)CuC6F5 (3) and (DAC)Cu(2,4,6-Me3
  61. Zhang D, Dera P, Eng P, Stubbs J, Zhang J, Prakapenka V, et al. High Pressure Single Crystal Diffraction at PX^2. J Vis Exp. 2017;: pubmed publisher
    ..detailed procedures for carrying out single crystal X-ray diffraction experiments with a diamond anvil cell (DAC) at the GSECARS 13-BM-C beamline at the Advanced Photon Source...
  62. Anraku M, Tabuchi R, Ifuku S, Nagae T, Iohara D, Tomida H, et al. An oral absorbent, surface-deacetylated chitin nano-fiber ameliorates renal injury and oxidative stress in 5/6 nephrectomized rats. Carbohydr Polym. 2017;161:21-25 pubmed publisher
    ..SDACNFs) are more effective in decreasing renal injury and oxidative stress than deacetylated chitin powder (DAC) in 5/6 nephrectomized rats...
  63. Tomeczkowski J, Lange A, Güntert A, Thilakarathne P, Diels J, Xiu L, et al. Converging or Crossing Curves: Untie the Gordian Knot or Cut it? Appropriate Statistics for Non-Proportional Hazards in Decitabine DACO-016 Study (AML). Adv Ther. 2015;32:854-62 pubmed publisher
    ..myeloid leukemia (AML), the DACO-016 randomized study showed reduction in mortality for decitabine [Dacogen(®) (DAC), Eisai Inc...
  64. Yang S, Wu B, Sun H, Ji F, Sun T, Zhao Y, et al. Interrupted E2F1-miR-34c-SCF negative feedback loop by hyper-methylation promotes colorectal cancer cell proliferation. Biosci Rep. 2015;36:e00293 pubmed publisher
    ..in a p53 independent manner but profoundly promoted in the presence of p53 with exposure to 5-aza-2'-deoxycytidine (DAC)...
  65. Li Q, Barish S, Okuwa S, Maciejewski A, Brandt A, Reinhold D, et al. A Functionally Conserved Gene Regulatory Network Module Governing Olfactory Neuron Diversity. PLoS Genet. 2016;12:e1005780 pubmed publisher
    ..Here, we show that Rn, along with BarH1/H2 (Bar), Bric-à-brac (Bab), Apterous (Ap) and Dachshund (Dac), constitutes a transcription factor (TF) network that patterns the developing olfactory tissue...
  66. Chen S, Zhao Y, Wu W, Ma T, Chen S. [Effect of Decitabine in Combination with Arsenic Trioxide on Prolife-ration and Apoptosis of Human Acute Myeloid Leukemia MV4-11 Cells]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:1343-1347 pubmed publisher
    To investigate the effect of decitabine (DAC) alone or in combination with arsenic trioxide (As2O3) on the proliferation and apoptosis of human acute myeloid leukemia (AML) MV4-11 cells, so as to find an effective ..
  67. Qiu Y, Yu H, Zhu Y, Ye Z, Deng J, Su W, et al. Hypermethylation of Interferon Regulatory Factor 8 (IRF8) Confers Risk to Vogt-Koyanagi-Harada Disease. Sci Rep. 2017;7:1007 pubmed publisher
    ..A demethylation reagent, 5-Aza-2'-deoxycytidine (DAC) showed a notable demethylation effect as evidenced by increasing the mRNA expression and reducing the methylation ..
  68. Qiao S, Zhou W, Liu L, Zhang D, Zhong Y. Orexin-A Suppresses Signal Transmission to Dopaminergic Amacrine Cells From Outer and Inner Retinal Photoreceptors. Invest Ophthalmol Vis Sci. 2017;58:4712-4721 pubmed publisher
    ..orexin receptor 1 antagonist SB334867 and orexin receptor 2 antagonist TCS OX229 enhanced melanopsin-based DAC responses, indicating that endogenous orexins inhibit signal transmission from ipRGCs to DACs...
  69. Wu M, Wang S, Cai C, Tan J, Li M, Lu J, et al. Natural autophagy blockers, dauricine (DAC) and daurisoline (DAS), sensitize cancer cells to camptothecin-induced toxicity. Oncotarget. 2017;8:77673-77684 pubmed publisher
    ..In our study, we identified two natural compounds, dauricine (DAC) and daurisoline (DAS), as two potent autophagy blockers through a high-content screening...
  70. Ilper H, Grossbach A, Franz Jäger C, Byhahn C, Klages M, Ackermann H, et al. Thyromental distance ("Patil") revisited : Knowledge and performance of a basic airway screening tool among European anesthetists. Anaesthesist. 2018;67:198-203 pubmed publisher
    ..a difficult airway on participants at the Euroanaesthesia (ESA) congress and German Anaesthesia Congress (DAC) in 2014...
  71. Wikiera A, Mika M, Starzyńska Janiszewska A, Stodolak B. Application of Celluclast 1.5L in apple pectin extraction. Carbohydr Polym. 2015;134:251-7 pubmed publisher
    ..galacturonic acid (GalA) content, the neutral sugars (NS) profile, the degree of methylation (DM) and acetylation (DAc), the molecular mass, protein, ash and polyphenol levels as well as antioxidant and antitumor activity were ..
  72. Adikrishna A, Kim J, Kekatpure A, Lee H, Kim M, Jeon I. Dorsal apex curve of the proximal ulna. Acta Orthop Traumatol Turc. 2016;50:97-102 pubmed publisher
    ..and angulations along the curvature in the posterior border of the proximal ulna-termed the "dorsal apex curve" (DAC)-using the computer-aided design software. Eight pairs of normal cadaveric ulnae were analyzed...
  73. Wu D, Zhang Y, Zhao Y, Guo J, Chang C. [Inhibitory Effect of Decitabine on Proliferation of MDS-L Cells and Its Mechanism]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2017;25:1471-1476 pubmed publisher
    To investigate the inhibitory effect of decitabine (DAC) in various dosages on the proliferention of MDS-RAEB cell line MDS-L and its mechanism...
  74. Mziaut H, Korza G, Hand A, Gerard C, Ozols J. Targeting proteins to the lumen of endoplasmic reticulum using N-terminal domains of 11beta-hydroxysteroid dehydrogenase and the 50-kDa esterase. J Biol Chem. 1999;274:14122-9 pubmed
  75. Freed A, Wang Y, McCulloch S, Myers T, Suzuki R. Mucosal injury and eicosanoid kinetics during hyperventilation-induced bronchoconstriction. J Appl Physiol (1985). 1999;87:1724-33 pubmed
    ..We found that epithelial cells increased in BALF immediately after a 2- and a 5-min dry air challenge (DAC)...
  76. Nourbakhsh M, Douglas D, Pu C, Lewis J, Kawahara T, Lisboa L, et al. Arylacetamide deacetylase: a novel host factor with important roles in the lipolysis of cellular triacylglycerol stores, VLDL assembly and HCV production. J Hepatol. 2013;59:336-43 pubmed publisher
    ..This was partially explained by an apparent deficiency of a putative TG lipase, arylacetamide deacetylase (AADAC)...
  77. Toeri J, Osorio Madrazo A, Laborie M. Preparation and Chemical/Microstructural Characterization of Azacrown Ether-Crosslinked Chitosan Films. Materials (Basel). 2017;10: pubmed publisher
    ..crosslink bridges were produced between the amine groups of chitosan (Ch) and the allyl groups of the azacrown (DAC)...
  78. Tang Z, Cao W, Guo X, Dai X, Lu J, Chen X, et al. Identification of a novel autophagic inhibitor cepharanthine to enhance the anti-cancer property of dacomitinib in non-small cell lung cancer. Cancer Lett. 2018;412:1-9 pubmed publisher
    ..Furthermore, we found for the first time that dacomitinib (DAC), a second-generation epidermal growth factor receptor inhibitor that in the phase III clinical trials for NSCLC ..
  79. Cui J, Xiao Y, You Y, Shi W, Li Q, Luo Y, et al. Decitabine for relapsed acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation. J Huazhong Univ Sci Technolog Med Sci. 2017;37:693-698 pubmed publisher
    ..Our study assessed the efficacy of decitabine (DAC) for treating patients with acute lymphoblastic leukemia (ALL) who relapsed after allogeneic hematopoietic stem ..
  80. Schroeder T, Rautenberg C, Haas R, Germing U, Kobbe G. Hypomethylating agents for treatment and prevention of relapse after allogeneic blood stem cell transplantation. Int J Hematol. 2018;107:138-150 pubmed publisher
    ..Given this unmet medical need the hypomethylating agents (HMA), Azacitidine (Aza) and Decitabine (DAC) have been tested as salvage therapy in patients with myeloid malignancies relapsing after allo-SCT...
  81. Ueda K, Masuda A, Fukuda M, Tanaka S, Hosokawa M, Iwakawa S. Monophosphorylation by deoxycytidine kinase affects apparent cellular uptake of decitabine in HCT116 colon cancer cells. Drug Metab Pharmacokinet. 2017;32:301-310 pubmed publisher
    Decitabine (DAC), a nucleoside-related DNA methylation inhibitor, is taken up into cancer cells via equilibrative nucleoside transporter 1 (ENT1), and is then monophosphorylated by deoxycytidine kinase (dCK)...
  82. Ramakrishnan S, Hu Q, Krishnan N, Wang D, Smit E, Granger V, et al. Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer. Cell Death Dis. 2017;8:3217 pubmed publisher
    ..DNA-demethylating agents such as Decitabine (DAC)/Azacitidine (AZA) activate otherwise silenced tumor suppressor genes, alter immune response and epigenetically ..
  83. Freed A, Taskar V, Schofield B, Omori C. Hyperventilation-induced airway injury and vascular leakage in dogs: effects of alpha1-adrenergic agonists. J Appl Physiol (1985). 1997;83:1884-9 pubmed
    ..methoxamine (Mx), norepinephrine (NE), or saline aerosol; and then exposed to a 2,000 ml/min dry-air challenge (DAC) for 2 min. Colloidal carbon was injected before DAC and used to quantify bronchovascular permeability...
  84. Ferreira R, Pan Hammarstrom Q, Graham R, Gateva V, Fontan G, Lee A, et al. Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. Nat Genet. 2010;42:777-80 pubmed publisher
    ..0 x 10(-4)) or random SNPs across the genome (P < 0.0001). These findings support the hypothesis that autoimmune mechanisms may contribute to the pathogenesis of IgAD. ..
  85. Tarasevicius S, Robertsson O, Dobozinskas P, Wingstrand H. A comparison of outcomes and dislocation rates using dual articulation cups and THA for intracapsular femoral neck fractures. Hip Int. 2013;23:22-6 pubmed publisher
    ..The aim of our study was to investigate FNF patients treated with dual articulation cups (DAC) and conventional THA and compare their clinical results at four months and one year after surgery...
  86. Zhang Y, Mei Q, Liu Y, Li X, Brock M, Chen M, et al. The safety, efficacy, and treatment outcomes of a combination of low-dose decitabine treatment in patients with recurrent ovarian cancer. Oncoimmunology. 2017;6:e1323619 pubmed publisher
    ..Clinical benefits could be associated with the number of DAC treatment cycles and the inclusion of CIK immunotherapy. In DTC+CIK cohort, DCR and ORR reached 100% and 58...
  87. Shaw Z, Feilner W, Esser B, Dickens J, Neuber A. A software controllable modular RF signal generator with multichannel transmission capabilities. Rev Sci Instrum. 2017;88:094706 pubmed publisher
    ..Each channel is comprised of a data pattern generator (DPG), a digital to analog converter (DAC), a power amplifier, and a transmitting antenna...
  88. Abbo B, Hulslander L, Goldade D. Determination of 20, 25-diazacholesterol in avian matrices by high performance liquid chromatography/tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2017;1065-1066:129-133 pubmed publisher
    ..One promising avian contraceptive compound, 20,25-diazacholesterol (DAC), reduces fertility by inhibiting cholesterol synthesis...
  89. Xiao Z, Zhuge Q, Fu S, Zhang F, Qiu M, Tang M, et al. Low complexity split digital backpropagation for digital subcarrier-multiplexing optical transmissions. Opt Express. 2017;25:27824-27833 pubmed publisher
    ..We also numerically investigate the impact of the digital-to-analog converter (DAC) resolution and fiber parameter uncertainties on the nonlinear compensation performance of the SSDBP.
  90. Schroeder T, Rautenberg C, Krüger W, Platzbecker U, Bug G, Steinmann J, et al. Treatment of relapsed AML and MDS after allogeneic stem cell transplantation with decitabine and DLI-a retrospective multicenter analysis on behalf of the German Cooperative Transplant Study Group. Ann Hematol. 2018;97:335-342 pubmed publisher
    ..to the evidence regarding azacitidine (Aza), there is limited knowledge about the combination of decitabine (DAC) and donor lymphocyte infusions as salvage therapy for relapse after allogeneic stem cell transplantation (allo-SCT)..
  91. Yamazaki K, Kusano K, Tadano K, Tanaka I. Radiation hybrid mapping of human arylacetamide deacetylase (AADAC) locus to chromosome 3. Genomics. 1997;44:248-50 pubmed
  92. Nakajima A, Fukami T, Kobayashi Y, Watanabe A, Nakajima M, Yokoi T. Human arylacetamide deacetylase is responsible for deacetylation of rifamycins: rifampicin, rifabutin, and rifapentine. Biochem Pharmacol. 2011;82:1747-56 pubmed publisher
    ..In this study, we found that recombinant human arylacetamide deacetylase (AADAC) could efficiently deacetylate rifamycins, whereas human carboxylesterases, which are enzymes ..