A20

Summary

Gene Symbol: A20
Description: tumor necrosis factor, alpha-induced protein 3
Alias: A20, OTUD7C, TNFA1P2, OTU domain-containing protein 7C, TNF alpha-induced protein 3, tumor necrosis factor alpha-induced protein 3, tumor necrosis factor inducible protein A20, zinc finger protein A20
Species: human

Top Publications

  1. ncbi De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
    Ingrid E Wertz
    Department of Molecular Oncology, School of Medicine, University of California, Davis, Davis, California 95616, USA
    Nature 430:694-9. 2004
  2. pmc Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
    Robert R Graham
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Nat Genet 40:1059-61. 2008
  3. doi Frequent inactivation of A20 in B-cell lymphomas
    Motohiro Kato
    Cancer Genomics Project, Department of Pediatrics, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 459:712-6. 2009
  4. pmc Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
    Indra Adrianto
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Nat Genet 43:253-8. 2011
  5. doi The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Nat Immunol 9:254-62. 2008
  6. pmc The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, The University of Miami, Miami, FL 33136, USA
    EMBO J 28:513-22. 2009
  7. pmc The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas
    Urban Novak
    Institute for Cancer Genetics, Departments of Pathology and Genetics and Development, and The Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    Blood 113:4918-21. 2009
  8. pmc Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
    Rajan P Nair
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 41:199-204. 2009
  9. doi Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
    Stacy L Musone
    Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Nat Genet 40:1062-4. 2008
  10. ncbi 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules
    C Vincenz
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 271:20029-34. 1996

Detail Information

Publications202 found, 100 shown here

  1. ncbi De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
    Ingrid E Wertz
    Department of Molecular Oncology, School of Medicine, University of California, Davis, Davis, California 95616, USA
    Nature 430:694-9. 2004
    ..to downregulate NF-kappaB transcriptional activity results in chronic inflammation and cell death, as observed in A20-deficient mice. A20 is a potent inhibitor of NF-kappaB signalling, but its mechanism of action is unknown...
  2. pmc Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
    Robert R Graham
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Nat Genet 40:1059-61. 2008
    ..These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA...
  3. doi Frequent inactivation of A20 in B-cell lymphomas
    Motohiro Kato
    Cancer Genomics Project, Department of Pediatrics, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 459:712-6. 2009
    b>A20 is a negative regulator of the NF-kappaB pathway and was initially identified as being rapidly induced after tumour-necrosis factor-alpha stimulation...
  4. pmc Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus
    Indra Adrianto
    Arthritis and Clinical Immunology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma, USA
    Nat Genet 43:253-8. 2011
    ..TNFAIP3, encoding the ubiquitin-modifying enzyme A20, is an established susceptibility locus for SLE...
  5. doi The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, Miami, Florida 33136, USA
    Nat Immunol 9:254-62. 2008
    The ubiquitin-editing enzyme A20 is a critical negative regulator of inflammation and cytokine-mediated activation of the transcription factor NF-kappaB; however, little is known about the mechanisms of A20-mediated inactivation of ..
  6. pmc The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, The University of Miami, Miami, FL 33136, USA
    EMBO J 28:513-22. 2009
    ..RNF11 interacted with the NF-kappaB inhibitor A20 and its regulatory protein TAX1BP1 in a stimulus-dependent manner...
  7. pmc The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas
    Urban Novak
    Institute for Cancer Genetics, Departments of Pathology and Genetics and Development, and The Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    Blood 113:4918-21. 2009
    ..deletions of the chromosomal band 6q23, involving the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) gene, a negative regulator of NF-kappaB, were described in ocular adnexal MZL, suggesting a role for A20 as a ..
  8. pmc Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways
    Rajan P Nair
    Department of Dermatology, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Genet 41:199-204. 2009
    ..Our results expand the catalog of genetic loci implicated in psoriasis susceptibility and suggest priority targets for study in other auto-immune disorders...
  9. doi Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
    Stacy L Musone
    Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Nat Genet 40:1062-4. 2008
    The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-kappaB-dependent signaling and prevents inflammation...
  10. ncbi 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules
    C Vincenz
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 271:20029-34. 1996
    b>A20, a novel zinc finger protein, is an inhibitor of tumor necrosis factor-induced apoptosis. The mechanism by which A20 exerts its protective effect is currently unknown...
  11. doi TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas
    Keiichiro Honma
    Aichi Cancer Center Research Institute, Nagoya, Japan
    Blood 114:2467-75. 2009
    ..shown that chromosome 6q was frequently deleted in ocular marginal zone B-cell lymphoma and identified TNFAIP3/A20, a negative regulator of NF-kappaB pathways, as the primary target for 6q deletion...
  12. pmc Sequencing of TNFAIP3 and association of variants with multiple autoimmune diseases
    S L Musone
    Cardiovascular Research Institute and Institute for Human Genetics, University of California San Francisco, San Francisco, CA, USA
    Genes Immun 12:176-82. 2011
    The TNFAIP3 locus at 6q23, encoding A20, has been associated with multiple autoimmune diseases (AIDs)...
  13. doi A20, ABIN-1/2, and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma
    Gehong Dong
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom
    Clin Cancer Res 17:1440-51. 2011
    ..Activating mutations of CARD11 and inactivating mutations of A20 are frequent events in DLBCL...
  14. doi Tumor suppressor TNFAIP3 (A20) is frequently deleted in Sézary syndrome
    F C M Braun
    Clinic for Internal Medicine C, University Greifswald, Greifswald, Germany
    Leukemia 25:1494-501. 2011
    ..We identified bi- and monoallelic deletions of the tumor necrosis factor-α-induced protein 3 gene (TNFAIP3; A20) in a high proportion of SS patients as well as biallelic A20 deletion in the SS-derived cell line SeAx...
  15. pmc A20 (TNFAIP3) genetic alterations in EBV-associated AIDS-related lymphoma
    Lisa Giulino
    Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Blood 117:4852-4. 2011
    b>A20, a negative regulator of NF-κB, has been implicated as a tumor suppressor gene in multiple types of B-cell lymphoma. AIDS-related lymphomas (ARLs) are high-grade B-cell lymphomas that are frequently associated with EBV infection...
  16. doi Analysis of 17 autoimmune disease-associated variants in type 1 diabetes identifies 6q23/TNFAIP3 as a susceptibility locus
    E Y M G Fung
    Juvenile Diabetes Research Foundation Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
    Genes Immun 10:188-91. 2009
    ..70 x 10(-3) to 3.20 x 10(-5). These findings extend our knowledge of susceptibility locus sharing across different autoimmune diseases, and provide convincing evidence that the RA/SLE locus 6q23/TNFAIP3 is a newly identified T1D locus...
  17. pmc TNFAIP3 maintains intestinal barrier function and supports epithelial cell tight junctions
    Lauren E Kolodziej
    Department of Medicine, University of Chicago, Chicago, Illinois, United States of America
    PLoS ONE 6:e26352. 2011
    ..These in vivo and in vitro studies support the role of TNFAIP3 in promoting intestinal epithelial barrier integrity and demonstrate its novel ability to maintain intestinal homeostasis through tight junction protein regulation...
  18. pmc ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development
    Shigeru Oshima
    Department of Medicine, University of California at San Francisco, 513 Parnassus Avenue, S 1057, San Francisco, California 94143 0451, USA
    Nature 457:906-9. 2009
    ..ABIN-1 (A20 binding and inhibitor of NF-kappaB) is a novel protein that is thought to inhibit NF-kappaB signalling...
  19. pmc Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
    E G Lee
    Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, MC 6084, Chicago, IL 60637, USA
    Science 289:2350-4. 2000
    b>A20 is a cytoplasmic zinc finger protein that inhibits nuclear factor kappaB (NF-kappaB) activity and tumor necrosis factor (TNF)-mediated programmed cell death (PCD)...
  20. pmc Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20
    Su Chang Lin
    Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Mol Biol 376:526-40. 2008
    ..b>A20 is a specific feedback inhibitor of NF-kappaB activation in these pathways that possesses dual ubiquitin-editing ..
  21. doi The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population
    Kenichi Shimane
    Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 62:574-9. 2010
    ..The aim of this study was to assess the role of TNFAIP3 in the development of SLE and RA in Japanese subjects...
  22. ncbi The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein
    A W Opipari
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    J Biol Chem 265:14705-8. 1990
    We have previously identified in endothelial cells a gene product designated A20, that is rapidly and profoundly induced by tumor necrosis factor alpha (Dixit, V. M., Green, S., Sarma, V., Holzman, L. B., Wolf, F. W., O'Rourke, K...
  23. pmc Association of TNFAIP3 interacting protein 1, TNIP1 with systemic lupus erythematosus in a Japanese population: a case-control association study
    Aya Kawasaki
    Molecular and Genetic Epidemiology Laboratory, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Arthritis Res Ther 12:R174. 2010
    ..involved in inhibition of nuclear factor-κB (NF-κB) activation by interacting with TNF alpha-induced protein 3, A20 (TNFAIP3), an established susceptibility gene to systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA)...
  24. pmc African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity
    James P Lodolce
    Department of Medicine, University of Chicago, Chicago, IL 60612, USA
    J Immunol 184:7001-9. 2010
    ..This is the first report of an association between TNFAIP3 polymorphisms and autoimmunity in African-Americans...
  25. pmc Regulation of inflammatory and antiviral signaling by A20
    Kislay Parvatiyar
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, The University of Miami, Miller School of Medicine, 1550 NW 10 Avenue, Miami, FL 33136, USA
    Microbes Infect 13:209-15. 2011
    The deubiquitinating enzyme A20 (also known as TNFAIP3) is essential for maintaining immune homeostasis. A20 is a key regulator of inflammatory, antiviral and apoptotic signaling pathways...
  26. pmc A20 inactivation in ocular adnexal MALT lymphoma
    Yingwen Bi
    Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    Haematologica 97:926-30. 2012
    Recent studies showed A20 inactivation by deletion, mutation and promoter methylation in ocular adnexal mucosa-associated lymphoid tissue lymphoma...
  27. pmc Deletion of the TNFAIP3/A20 gene detected by FICTION analysis in classical Hodgkin lymphoma
    Junko Nomoto
    Hematology Division, National Cancer Center Hospital, Tokyo, Japan
    BMC Cancer 12:457. 2012
    The TNFAIP3 gene, which encodes a ubiquitin-modifying enzyme (A20) involved in the negative regulation of NF-κB signaling, is frequently inactivated by gene deletions/mutations in a variety of B-cell malignancies...
  28. pmc Genome-wide association scan yields new insights into the immunopathogenesis of psoriasis
    J T Elder
    Department of Dermatology, University of Michigan Medical School, Ann Arbor, MI 48109 0932, USA
    Genes Immun 10:201-9. 2009
    ....
  29. ncbi A20, an inhibitor of cell death, self-associates by its zinc finger domain
    D De Valck
    Laboratory of Molecular Biology, University of Gent, Belgium
    FEBS Lett 384:61-4. 1996
    b>A20 is a primary response gene which is induced after monocyte adherence or cytokine stimulation of a variety of cells...
  30. ncbi A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins
    D De Valck
    Laboratory of Molecular Biology, Flanders Interuniversity Institute for Biotechnology, University of Ghent, K L Ledeganckstraat 35, Ghent, B 9000, Belgium
    Biochem Biophys Res Commun 238:590-4. 1997
    The A20 protein, which belongs to a class of Cys2/Cys2 zinc finger proteins, has been characterized as an inhibitor of NF-kappaB activation...
  31. ncbi Attenuated expression of A20 markedly increases the efficacy of double-stranded RNA-activated dendritic cells as an anti-cancer vaccine
    Karine Breckpot
    Laboratory of Molecular and Cellular Therapy, Department of Physiology Immunology, Medical School of the Vrije Universiteit Brussel, Brussels, Belgium
    J Immunol 182:860-70. 2009
    b>A20 is a zinc finger protein with ubiquitin-modifying activity...
  32. ncbi A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism
    J T Cooper
    Sandoz Center for Immunobiology, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 271:18068-73. 1996
    The A20 gene product is a novel zinc finger protein originally described as a tumor necrosis factor alpha (TNF)-inducible early response gene in human umbilical vein endothelial cells (HUVEC)...
  33. pmc Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)...
  34. ncbi ABIN-1 binds to NEMO/IKKgamma and co-operates with A20 in inhibiting NF-kappaB
    Claudio Mauro
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Federico II, University of Naples, Via S Pansini, 5, 80131 Naples, Italy
    J Biol Chem 281:18482-8. 2006
    ..Here we identified ABIN-1 (A20 binding inhibitor of NF-kappaB) as a NEMO/IKKgamma-interacting protein...
  35. doi A single-nucleotide polymorphism of the TNFAIP3 gene is associated with systemic lupus erythematosus in Chinese Han population
    Li Qiong Cai
    Department of Dermatology, Institute of Dermatology, The First Hospital, Anhui Medical University, 81 Meishan Road, Hefei, Anhui, People s Republic of China
    Mol Biol Rep 37:389-94. 2010
    ..Our findings suggest that SNP rs2230926 in the TNFAIP3 might be a common genetic factor for SLE within different populations in terms of Chinese Han and European population...
  36. pmc A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme
    Barbara A Malynn
    Program in Biomedical Sciences, Program in Biological Sciences, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 206:977-80. 2009
    ..A new study identifies somatic mutations in TNFAIP3, the gene encoding the NF-kappaB inhibitor A20, in Hodgkin lymphomas and primary mediastinal lymphomas...
  37. ncbi The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6
    K Heyninck
    Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology and University of Ghent, Belgium
    FEBS Lett 442:147-50. 1999
    The zinc finger protein A20 is encoded by an immediate early response gene whose expression is induced by different inflammatory stimuli, including interleukin-1 (IL-1)...
  38. ncbi Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20
    Rongtuan Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 281:2095-103. 2006
    ..In the present study, we demonstrate that the NF-kappaB-inducible, anti-apoptotic protein A20 efficiently blocks RIG-I-mediated activation of NF-kappaB-, IRF-3-, and IRF-7-dependent promoters but only weakly ..
  39. pmc Mutations in the genes coding for the NF-κB regulating factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin's lymphoma
    Martin A Schumacher
    Institute of Cell Biology Cancer Research, Medical School, University of Duisburg Essen, Essen, Germany
    Haematologica 95:153-7. 2010
    ..mutations in the NFKBIA and TNFAIP3 genes, coding for the negative NF-kappaB regulators IkappaBalpha and A20, respectively, contribute to NF-kappaB activation...
  40. pmc Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations
    J S Bates
    Oklahoma Medical Research Foundation, Arthritis and Immunology Research Program, Oklahoma City, OK 73104, USA
    Genes Immun 10:470-7. 2009
    TNFAIP3 encodes the ubiquitin-modifying enzyme, A20, a key regulator of inflammatory signaling pathways. We previously reported association between TNFAIP3 variants and systemic lupus erythematosus (SLE)...
  41. ncbi Structure-function analysis of the A20-binding inhibitor of NF-kappa B activation, ABIN-1
    Karen Heyninck
    Department of Molecular Biomedical Research, Unit of Molecular Signal Transduction in Inflammation, Flanders Interuniversity Institute for Biotechnology, Ghent University, K L Ledeganckstraat 35, B 9000 Ghent, Belgium
    FEBS Lett 536:135-40. 2003
    ..Among others, the NF-kappa B-dependent zinc finger protein A20 is involved in the negative feedback regulation of NF-kappa B activation in response to tumor necrosis ..
  42. ncbi Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells
    Uta Kunter
    Division of Vascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Kidney Int 68:1520-32. 2005
    ..In endothelial cells, the Bcl family member A1 and the zinc finger protein A20 have redundant and dual antiapoptotic and anti-inflammatory effects...
  43. ncbi The A20 protein interacts with the Epstein-Barr virus latent membrane protein 1 (LMP1) and alters the LMP1/TRAF1/TRADD complex
    K L Fries
    Department of Microbiology and Immunology and the Lineberger Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7295, USA
    Virology 264:159-66. 1999
    ..b>A20, which is induced by LMP1 through NF-kB, can block NF-kB activation from both domains of LMP1 and inhibit JNK ..
  44. pmc The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation
    H Y Song
    Tularik, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 93:6721-5. 1996
    ..Here we show that TRAF1 and TRAF2 interact with A20, a zinc finger protein, whose expression is induced by agents that activate NF-kappaB...
  45. pmc A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation
    N Oshima
    Department of Internal Medicine II, Shimane University School of Medicine, Izumo, Shimane, Japan
    Clin Exp Immunol 159:185-98. 2010
    ..receptor (TLR)-mediated inflammatory responses and restore immune system balance, including the zinc-finger protein A20, a negative regulator of TLR signalling that inhibits nuclear factor kappa B (NF-kappaB) activity...
  46. pmc Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    Robert M Plenge
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1477-82. 2007
    ..We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23...
  47. ncbi TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in ocular adnexal marginal zone B cell lymphoma
    Keiichiro Honma
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
    Genes Chromosomes Cancer 47:1-7. 2008
    ..TNFAIP3 is an inhibitor of NF-kB signaling so that loss of this gene may play an important role in lymphomagenesis and suggests that TNFAIP3 may act as a tumor suppressor gene in ocular adnexal marginal zone B cell lymphoma...
  48. doi T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20
    Beatrice Coornaert
    Department of Molecular Biology, Ghent University, B 9052 Ghent, Belgium
    Nat Immunol 9:263-71. 2008
    ..Here we show that T cell antigen receptor stimulation induced recruitment of the NF-kappaB inhibitor A20 into a complex of MALT1 and the adaptor protein Bcl-10, leading to MALT1-mediated processing of A20...
  49. ncbi A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation
    Soizic Daniel
    Department of Surgery and Medicine, 99 Brookline Ave, Boston MA 02215, USA
    Blood 104:2376-84. 2004
    b>A20 is a stress response gene in endothelial cells (ECs)...
  50. ncbi Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes
    Watip Boonyasrisawat
    Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 56:499-505. 2007
    b>A20 or tumor necrosis factor (TNF)-induced protein 3 (TNFAIP3) is a negative regulator of nuclear factor-kappaB (NF-kappaB)...
  51. ncbi Neuroprotective effect of A20 on TNF-induced postischemic apoptosis
    Luyang Yu
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Room 901, Cell Biology Building, No 320 Yueyang Road, Shanghai 200031, China
    Neurochem Res 31:21-32. 2006
    ..TNF is critically involved in such neuronal apoptosis mediated by caspase pathways. A20 can inhibit TNF-induced apoptosis in many cell types...
  52. pmc TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma
    Roland Schmitz
    Institute of Cell Biology Cancer Research, Medical School, University of Duisburg Essen, 45122 Essen, Germany
    J Exp Med 206:981-9. 2009
    ..NF-kappaB activation through various stimuli is negatively regulated by the zinc finger protein A20. To determine whether A20 contributes to the pathogenesis of cHL, we sequenced TNFAIP3, encoding A20, in ..
  53. pmc Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population
    Aya Kawasaki
    Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305 8575, Japan
    J Biomed Biotechnol 2010:207578. 2010
    ..013). These results indicated that TNFAIP3 is a susceptibility gene to SLE both in the Caucasian and Asian populations...
  54. pmc The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN
    K Heyninck
    Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology, University of Ghent, B 9000 Ghent, Belgium
    J Cell Biol 145:1471-82. 1999
    The zinc finger protein A20 is a tumor necrosis factor (TNF)- and interleukin 1 (IL-1)-inducible protein that negatively regulates nuclear factor-kappa B (NF-kappaB)-dependent gene expression...
  55. ncbi The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases
    D De Valck
    Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology and University of Gent, Belgium
    Oncogene 18:4182-90. 1999
    b>A20 is a Cys2/Cys2 zinc finger protein which is induced by a variety of inflammatory stimuli and which has been characterized as an inhibitor of cell death by a yet unknown mechanism...
  56. doi A20 is overexpressed in glioma cells and may serve as a potential therapeutic target
    Qingdong Guo
    The Fourth Military Medical University, Xijing Hospital, Department of Neurosurgery, Xi an 710032, China
    Expert Opin Ther Targets 13:733-41. 2009
    b>A20 is a TNF-inducible primary response gene, which has been found to have antiapoptotic function in several cancer cells...
  57. ncbi Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays
    Joanne Gallagher
    The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    FEBS Lett 551:8-12. 2003
    ..The regulation of Nef-associated factor-1 (Naf1), an A20-binding, nuclear factor kappa B (NFkappaB) inhibitory protein was probed further given its putative role as an ..
  58. pmc A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells
    Kai Li He
    Immunobiology Center, Mount Sinai School of Medicine, New York, New York 10029, USA
    Mol Cell Biol 22:6034-45. 2002
    ..We show here that the zinc finger protein A20 is an NF-kappaB-inducible gene that can protect the IKKgamma-deficient cells from TNF-induced apoptosis ..
  59. pmc Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity
    Paul C Evans
    Molecular Immunology Programme, The Babraham Institute, Cambridge CB2 4AT, UK
    Biochem J 378:727-34. 2004
    ..The zinc-finger protein A20 has dual functions in inhibiting NF-kappaB activation and suppressing apoptosis...
  60. ncbi A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells
    J A Vendrell
    CNRS UMR 5160, Centre de Pharmacologie et Biotechnologie pour la Santé, Faculte de Pharmacie, Montpellier, France
    Oncogene 26:4656-67. 2007
    The zinc-finger protein A20/TNFAIP3, an inhibitor of nuclear factor-kappaB (NF-kappaB) activation, has been shown to protect MCF-7 breast carcinoma cells from TNFalpha-induced apoptosis...
  61. ncbi Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin
    V M Dixit
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    J Biol Chem 265:2973-8. 1990
    ..Interleukin-1 beta and lipopolysaccharide are also potent inducers. Nuclear run-on studies revealed that in most cases induction by TNF is mediated largely at the transcriptional level...
  62. pmc Strain-ecotype specificity in Sinorhizobium meliloti-Medicago truncatula symbiosis is correlated to succinoglycan oligosaccharide structure
    Senay Simsek
    Whistler Center for Carbohydrate Research, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907 2009, USA
    J Bacteriol 189:7733-40. 2007
    ..meliloti Rm41 and NRG247 are Fix+ (compatible) on M. truncatula A20 and Fix- (incompatible) on M. truncatula A17, the Fix phenotypes are reversed with S...
  63. ncbi Fas-mediated activation of phospholipase D is coupled to the stimulation of phosphatidylcholine-specific phospholipase C in A20 cells
    J S Han
    College of Medicine, Hanyang University, Seoul, 133 791, Korea
    Arch Biochem Biophys 367:233-9. 1999
    The activation of phospholipase D in murine B cell lymphoma A20 cells treated with anti-Fas monoclonal antibody has been investigated. Fas cross-linking resulted in a both dose- and time-dependent increases in phospholipase D activity...
  64. pmc Myosin light chain-activating phosphorylation sites are required for oogenesis in Drosophila
    P Jordan
    Centre de Genetique Moleculaire, 91198 Gif sur Yvette, France
    J Cell Biol 139:1805-19. 1997
    ..In addition, numerous aggregates of myosin heavy chain accumulate in the sqh null cells. Mutant sqh transgene sqh-A20, A21 in which both serine-21 and threonine-20 have been replaced by alanines behaves in most respects identically ..
  65. ncbi Associations among serum lipoprotein(a) levels, apolipoprotein(a) phenotypes, and myocardial infarction in patients with extremely low and high levels of serum lipoprotein(a)
    K Saku
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    Jpn Circ J 63:659-65. 1999
    ..higher percentages of smaller isoforms (A1-A4, A5-A9) and decreasingly lower percentages of large isoforms (A10-A20, A21-A25) compared to Group I. An apparent inverse relationship existed between Lp(a) and the apo(a) phenotype...
  66. pmc Mengovirus and encephalomyocarditis virus poly(C) tract lengths can affect virus growth in murine cell culture
    L R Martin
    Institute for Molecular Virology and Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 74:3074-81. 2000
    ..Replication and cytopathic studies with four hematopoietically derived cell lines (CH2B, RAW 264.7, A20.J, and P815) and two murine fibroblast cell lines [L929 and L(Y)] demonstrated that several of these cell types ..
  67. ncbi An essential role of antigen-presenting cell/T-helper type 1 cell-cell interactions in draining lymph node during complete eradication of class II-negative tumor tissue by T-helper type 1 cell therapy
    Kenji Chamoto
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Cancer Res 66:1809-17. 2006
    ..of ovalbumin (OVA)-specific T helper type 1 (Th1) cells into mice bearing MHC class II+ OVA-expressing tumor cells (A20-OVA) causes complete tumor rejection...
  68. ncbi Metaphit-induced audiogenic seizures in mice: II. Studies on N-methyl-D-aspartic acid, GABA, and sodium channel receptors and on the disposition of metaphit in the brain
    M N Lipovac
    Division of Neurochemistry, Nathan S Kline Institute, Orangeburg, New York
    Epilepsia 34:211-9. 1993
    ..complex, for [3H]muscimol on the gamma-aminobutyric acid (GABA) receptor complex, and for [3H]batrachotoxinin A20-alpha-benzoate on the voltage-dependent sodium channel...
  69. pmc The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose
    A Kupfer
    Department of Biology, University of California at San Diego, La Jolla 92093
    J Exp Med 170:1697-713. 1989
    ..The Th cell was directed to a peptide fragment of the Ag OVA in the context of IAd. The B-APC was the transfected A20 B hybridoma cell A20-HL, bearing on its surface a surface Ig specific for the hapten TNP, and pulsed with different ..
  70. doi ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling
    Lynn Verstrepen
    Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, B 9052 Zwijnaarde, Belgium
    Biochem Pharmacol 78:105-14. 2009
    ..ABIN-1, ABIN-2, ABIN-3) that bind the ubiquitin-editing nuclear factor-kappaB (NF-kappaB) inhibitor protein A20 and which show limited sequence homology...
  71. ncbi Use of persistent infections with vaccinia virus recombinants to introduce alterations in foreign proteins: an application to HIV-1 env protein
    M Esteban
    Department of Cell and Molecular Biology, CSIC, Madrid, Spain
    Virus Res 46:45-56. 1996
    ..of use in studies of their biological functions--we established a persistent infection on a B-lymphoma cell line (A20.2J) with vaccinia virus (VV) recombinants...
  72. pmc The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis
    Wei Kuang Liu
    Institute of Microbiology and Immunology, National Yang Ming University, 155, Sec 2, Li Rong Street, Pei Tou, Taipei 11211, Taiwan, Republic of China
    Biochem J 378:867-76. 2004
    ..We and others have previously identified the protein ABIN-2 (A20 binding inhibitor of NF-kappaB 2) as an inhibitor of NF-kappaB activation...
  73. pmc Identification of an I-Ed-restricted T-cell epitope of Escherichia coli outer membrane protein F
    Kristina M Williams
    Center for Food Safety and Applied Nutrition, Immunobiology Branch, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA
    Infect Immun 72:3907-13. 2004
    ..Class II(+) mouse lymphoma (A20) cells, but not class II(-) mouse mastocytoma (P815) cells, supported IL-2 secretion of hybridomas when substituted ..
  74. pmc A single gene, AIN, in Medicago truncatula mediates a hypersensitive response to both bluegreen aphid and pea aphid, but confers resistance only to bluegreen aphid
    John P Klingler
    Commonwealth Scientific and Industrial Research Organisation Entomology, Private Bag 5, Wembley, WA 6913, Australia
    J Exp Bot 60:4115-27. 2009
    ..kondoi Shinji) and the pea aphid (PA, Acyrthosiphon pisum (Harris)) were analysed using reference genotypes A17 and A20, their F(2) progeny and recombinant inbred lines...
  75. ncbi Dynamics of molecules involved in antigen presentation: effects of fixation
    B G Barisas
    Department of Chemistry, Colorado State University, Fort Collins 80523, USA
    Mol Immunol 36:701-8. 1999
    ..Lateral and rotational dynamics of the MHC class II antigen I-Ad on A20 cells fixed with various concentrations of paraformaldehyde were examined by fluorescence photobleaching recovery ..
  76. ncbi Graft-vs-leukemia activity and graft-vs-host disease induced by allogeneic Th1- and Th2-type CD4+ T cells in mice
    M Zeis
    2nd Department of Internal Medicine, University of Kiel, Kiel, Germany
    Hematol J 2:136-44. 2001
    ..Therefore, separation of GVL- and GVH-reactions is a long-standing goal of experimental studies dealing with allogeneic transplantation of hematopoietic stem cells...
  77. ncbi The cytosolic free Ca2+ in ectromelia (mousepox) virus stimulated cytotoxic T lymphocytes
    F N Toka
    Department of Microbiology and Immunology, Faculty of Veterinary Medicine, Warsaw Agricultural University SGGW, Poland
    Viral Immunol 9:159-167. 1996
    ..the activation of ectromelia virus (EV)-specific cytotoxic T lymphocytes (CTL) upon stimulation with EV-sensitized (A20) target cells or concanavalin A (Con A). The CTL originated from mice previously infected with EV...
  78. ncbi Arsenite-induced thymus atrophy is mediated by cell cycle arrest: a characteristic downregulation of E2F-related genes revealed by a microarray approach
    Keiko Nohara
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba 305 8506, Japan
    Toxicol Sci 101:226-38. 2008
    ..The same genes were also downregulated when mouse B-cell lymphoma A20 cells were exposed to arsenite...
  79. ncbi Role of ICAM-1 in antigen presentation demonstrated by ICAM-1 defective mutants
    L H Dang
    Division of Lymphocyte Biology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 144:4082-91. 1990
    We report a methodology for selecting APC with mutations that have impaired their ability to present Ag to T cells. A20 B lymphoblastoid cells were mutagenized and then repeatedly cocultured with murine T-T hybridomas in the presence of ..
  80. pmc Ubiquitin-binding domains
    James H Hurley
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892, USA
    Biochem J 399:361-72. 2006
    ..of this group has expanded rapidly and now includes at least sixteen domains: UBA, UIM, MIU, DUIM, CUE, GAT, NZF, A20 ZnF, UBP ZnF, UBZ, Ubc, UEV, UBM, GLUE, Jab1/MPN and PFU...
  81. ncbi A ten-residue domain (Y11-A20) in the NH2-terminus modulates membrane association of annexin A7
    Avinash Chander
    Department of Pediatrics, Stony Brook University School of Medicine, Stony Brook, NY 11794 8111, USA
    Biochim Biophys Acta 1761:775-84. 2006
    ..For binding and fusion of biological membranes, the 10-29-residue domain may be required although the annexin A7 properties are primarily modulated through the Y(11)-A(20) domain...
  82. pmc Structural and mutational studies of the recognition of the arginine tRNA-specific major identity element, A20, by arginyl-tRNA synthetase
    A Shimada
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 98:13537-42. 2001
    Arginyl-tRNA synthetase (ArgRS) recognizes two major identity elements of tRNA(Arg): A20, located at the outside corner of the L-shaped tRNA, and C35, the second letter of the anticodon...
  83. doi A stress-associated protein containing A20/AN1 zing-finger domains expressed in Medicago truncatula seeds
    Christine Gimeno-Gilles
    University of Angers, UMR 1191 Physiologie Moléculaire des Semences, IFR 149 QUASAV, 2 Boulevard Lavoisier, Angers Cedex 01, France
    Plant Physiol Biochem 49:303-10. 2011
    ..MtSAP1 is the first gene encoding a SAP with A20 and AN1 zinc-finger domains characterized in M. truncatula...
  84. ncbi Differential expression and function of A20 and TRAF1 in Hodgkin lymphoma and anaplastic large cell lymphoma and their induction by CD30 stimulation
    Horst Dürkop
    Institut fur Pathologie, UK Benjamin Franklin, Freie Universitat Berlin, Germany
    J Pathol 200:229-39. 2003
    b>A20 and TRAF1 are two anti-apoptotic components of the intracellular signalling pathway of the tumour necrosis factor receptor (TNFR) family. Induction of apoptosis seems to be a main function of these receptors...
  85. ncbi Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas
    Markus Bredel
    Division of Oncology, Center for Clinical Sciences Research, Institute for Computational and Mathematical Engineering, Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305 5151, USA
    J Clin Oncol 24:274-87. 2006
    ..Pre-existing and acquired drug resistance are major obstacles to the successful treatment of glioblastomas...
  86. ncbi Zinc and inflammatory/immune response in aging
    Sonya Vasto
    Immunosenescence Unit, Department of Pathobiology and Biomedical Methodologies, Palermo University, Corso Tukory 211, 90134 Palermo, Italy
    Ann N Y Acad Sci 1100:111-22. 2007
    ..of NF-kappaB have been attributed to the suppression of phosphorylation and degradation of the inhibitory proteins (A20) that normally sequester it in the cytoplasm...
  87. doi Effects on brain edema of crystalloid and albumin fluid resuscitation after brain trauma and hemorrhage in the rat
    Mårten Jungner
    Department of Anesthesiology and Intensive Care, Lund University and Lund University Hospital, Lund, Sweden
    Anesthesiology 112:1194-203. 2010
    ..To test this hypothesis, the authors compared groups resuscitated with either colloid or crystalloid...
  88. ncbi Elevated amount of Toll-like receptor 4 mRNA in bronchial epithelial cells is associated with airway inflammation in horses with recurrent airway obstruction
    Annerose Berndt
    Pulmonary Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University East Lansing, MI 48824, USA
    Am J Physiol Lung Cell Mol Physiol 292:L936-43. 2007
    ..The zinc finger protein A20 negatively regulates this pathway...
  89. pmc Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression
    Yanbao Xiong
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 286:7905-16. 2011
    ..Deficiencies in these signaling events in LPS-tolerant cells coincided with increased expression of A20, an essential deubiquitination enzyme, and sustained A20-IRAK1 associations...
  90. doi Oral administration of a soluble 1-3, 1-6 beta-glucan during prophylactic survivin peptide vaccination diminishes growth of a B cell lymphoma in mice
    Ulf Harnack
    Medical Clinic of Oncology and Hematology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Int Immunopharmacol 9:1298-303. 2009
    ..a soluble yeast-derived beta-(1-3), (1-6)-D-glucan on prophylactic peptide vaccination against the B cell lymphoma A20 in syngeneic Balb/c mice...
  91. doi Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis
    Nina A Daha
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 60:1255-60. 2009
    ....
  92. doi TRAF1 polymorphisms associated with rheumatoid arthritis susceptibility in Asians and in Caucasians
    Tae Un Han
    Korea Advanced Institute of Science and Technology, Daejeon, South Korea
    Arthritis Rheum 60:2577-84. 2009
    ..The aim of this study was to evaluate the RA-associated loci by genotyping previously reported SNPs and additional tag SNPs in a Korean population...
  93. pmc Degradation of complement 3 by streptococcal pyrogenic exotoxin B inhibits complement activation and neutrophil opsonophagocytosis
    Chih Feng Kuo
    Department of Nursing, I Shou University, Kaohsiung County, Taiwan
    Infect Immun 76:1163-9. 2008
    ..SPE B-treated, but not C192S-treated, serum also impaired opsonization of C3 fragments on the surface of GAS strain A20. Moreover, the amount of C3 fragments on the A20 cell surface, a SPE B-producing strain, was less than that on its ..
  94. pmc Intragraft gene expression profile associated with the induction of tolerance
    Tomoko Doki
    Department of Cardiothoracic Surgery Research, Transplantation Biology Research Laboratory, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    BMC Immunol 9:5. 2008
    ..The mechanisms by which tolerance is achieved include systemic changes such as clonal deletion and/or anergy. Intragraft changes that occur during the early stages of tolerance induction have not been characterized...
  95. ncbi Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection
    Y B Ahn
    Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center and the Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Diabetologia 50:334-42. 2007
    ..In addition, hyperglycaemia after islet transplantation can compromise beta cell function. The aim of this experiment was to evaluate changes in gene expression in endogenous islets using laser-capture microdissection (LCM)...
  96. ncbi Expression of human complement receptor 2 (CR2, CD21) in Cr2-/- mice restores humoral immune function
    K J Marchbank
    Division of Rheumatology, Departments of Medicine and Immunology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 165:2354-61. 2000
    ..Transfection of P1-5 into the mouse A20 B cell line confirmed that it would direct expression of the hCR2 protein in mouse B cells...
  97. ncbi Computer simulations to identify in polyproteins of FMDV OK1 and A12 strains putative nonapeptides with amino acid motifs for binding to BoLA class I A11 and A20 haplotype molecules
    Y Becker
    Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, Israel
    Virus Genes 14:123-9. 1997
    ..for the availability of putative proteasome-generated nonapeptides with motifs reported for BoLA class I A11 and A20 haplotypes...
  98. ncbi Isolation and enzymatic characterization of lamjapin, the first ribosome-inactivating protein from cryptogamic algal plant (Laminaria japonica A)
    Ren Shui Liu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Eur J Biochem 269:4746-52. 2002
    ..Lamjapin can deadenylate specifically at the site A20 of the synthetic oligoribonucleotide (35-mer) substrate that mimics the sarcin/ricin domain (SRD) of rat ribosomal ..
  99. doi Inhibition of vaccinia virus replication by peptide aptamers
    Laurent Saccucci
    Institut de Recherches Biomédicales des Armées, CRSSA Emile Pardé, Grenoble, France
    Antiviral Res 82:134-40. 2009
    b>A20 protein is a major component of the vaccinia virus replication complex. It binds to the DNA polymerase E9, the uracil DNA glycosylase D4 and the primase/helicase D5, three proteins that are essential for viral DNA synthesis...
  100. doi A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes
    Roos C Padmos
    Department of Immunology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Arch Gen Psychiatry 65:395-407. 2008
    ..Mood disturbances are associated with an activated inflammatory response system...

Research Grants79

  1. IDENTIFICATION OF NATURALLY PROCESSED SMANSONI PEPTIDES
    Philip Loverde; Fiscal Year: 2001
    ..We had previously presented data showing that peptides eluted from MHC class II molecules of A20 cell line pulsed with NP40 extract of schistosomule stimulate a proliferative response in bulk lymph node cells ..
  2. VACCINIA DNA REPLICATION
    Paula Traktman; Fiscal Year: 2007
    ..The E9 DNA polymerase, A20 processivity factor, D4 uracil DNA glycosylase, D5 NTPase, I3 single-strand DNA binding protein, and B1 protein ..
  3. TNFAIP3 (A20) and Susceptibility to Systemic Lupus Erythematosus
    Patrick M Gaffney; Fiscal Year: 2010
    ..published work from our laboratory has identified and confirmed a convincing novel association with TNFAIP3 (A20), a critical negative regulator of NF-kB signaling...
  4. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2006
    ..Our preliminary data demonstrate that A20 promotes hepatocyte proliferation and is anti-apoptotic...
  5. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2003
    ..Our preliminary data demonstrate that A20 promotes hepatocyte proliferation and is anti-apoptotic...
  6. Immature intestinal NF-kB regulation, probiotics, and necrotizing enterocolitis
    Erika C Claud; Fiscal Year: 2010
    ..that compared to mature IEC, immature IEC have differences in regulation of both inhibitory kappaB alpha and A20 - key NF-kB down-regulatory proteins...
  7. Immature intestinal NF-kB regulation, probiotics, and necrotizing enterocolitis
    Erika C Claud; Fiscal Year: 2010
    ..that compared to mature IEC, immature IEC have differences in regulation of both inhibitory kappaB alpha and A20 - key NF-kB down-regulatory proteins...
  8. MEDIATORS AND MODIFIERS OF NF-kappaB IN INSULIN RESISTANCE
    Steven Shoelson; Fiscal Year: 2007
    ..As the subject of this proposal we also see constitutive, NF-kappaB dependent expression of A20, IKKi/epsilon, and IkappaBzeta, in fat and liver of obese/HFD rodent models...
  9. CD1 AND BCR/Fc RECEPTOR TARGETED LIGAND
    Grant Yeaman; Fiscal Year: 2001
    ..The construct will be linked to an anti-IgG2a (BCR) F(ab)2, and used to treat A20 B cells transfected with murine CDlda; galactosyl ceramide will also be examined in this system...
  10. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2009
    ..We have identified the 7-Zinc finger protein A20 as a critical component of the protective and regenerative responses of hepatocytes in that it protects ..
  11. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2010
    ..We have identified the 7-Zinc finger protein A20 as a critical component of the protective and regenerative responses of hepatocytes in that it protects ..
  12. VACCINIA DNA REPLICATION
    Paula Traktman; Fiscal Year: 2003
    ..kinase, the D4 uracil DNA glycosylase, the I3 single stranded binding protein, the D5 DNA-independent NTPase, the A20 processivity factor, and the E9 DNA polymerase...
  13. Activation of Macrophages in Human Autoimmune Diseases
    Lionel B Ivashkiv; Fiscal Year: 2010
    ..include linkage of ITGAM that encodes the 1M component of the 1M22 integrin, FCGR2A (Fc3RIIA), and TNFAIP3 (A20) with SLE and/or RA...
  14. VACCINIA DNA REPLICATION
    Paula Traktman; Fiscal Year: 2010
    ..The polymerase holoenzyme, comprised of the E9 DNA polymerase/A20 processivity factor/ D4 uracil DNA glycosylase will be the major topic of study...
  15. CHEMOKINE ENHANCED IMMUNE THERAPY OF LYMPHOMA
    Joseph Rosenblatt; Fiscal Year: 2002
    ..transduction and the antitumor activity of the chemokines when used alone and/or in combination with CD40L in the A20 murine B-cell lymphoma model...
  16. A new approach to xenotransplantation in primate
    Juan Contreras; Fiscal Year: 2005
    ..Expression in the graft of anti-apoptotic or "protective genes", such as Bcl-2, A20 BcI-xL and heme oxygenase-1 (HO-1), make the graft resistant to rejection...
  17. Gene transfer with A20 to improve islet transplantation
    Christiane Ferran; Fiscal Year: 2003
    ..Our preliminary data reveals that A20 is part of the physiological response of islets to injury...
  18. Vascular Remodeling in Transplant Arteriosclerosis
    Christiane Ferran; Fiscal Year: 2007
    ..We have shown that A20 is part of the regulatory cytoprotective response of EC to injury...
  19. Vascular Remodeling in Transplant Arteriosclerosis
    Christiane Ferran; Fiscal Year: 2009
    ..We have shown that A20 is part of the regulatory cytoprotective response of EC to injury...
  20. CD20 DNA VACCINATION FOR B-CELL LYMPHOMA
    Maria Palomba; Fiscal Year: 2007
    ..form of the human CD20 cDNA, administered to mice via particle bombardment and followed by a lethal challenge of A20 murine lymphoma cells, resulted in cellular immune responses against the human and mouse CD20 (therefore breaking ..
  21. Mechanisms of HTLV-I Tax-mediated NF-kB activation
    Edward Harhaj; Fiscal Year: 2009
    ..of cytokine-mediated NF-kB signaling by functioning as an essential subunit for the ubiquitin-editing enzyme A20. We hypothesize that Tax targets TAX1BP1 as part of a mechanism to promote persistent NF-kB activation...
  22. Mechanisms of HTLV-I Tax-mediated NF-kB activation
    Edward W Harhaj; Fiscal Year: 2010
    ..of cytokine-mediated NF-kB signaling by functioning as an essential subunit for the ubiquitin-editing enzyme A20. We hypothesize that Tax targets TAX1BP1 as part of a mechanism to promote persistent NF-kB activation...
  23. Developing novel adjuvants for HIV vaccination
    Si Yi Chen; Fiscal Year: 2009
    ..found that the negative regulators of proinflammatory signaling, such as the zinc-finger ubiquitin-modifying enzyme A20 and suppressor of cytokine signaling 1 (SOCS1), play critical roles in limiting the immunostimulatory potency of ..
  24. Developing novel adjuvants for HIV vaccination
    Si Yi Chen; Fiscal Year: 2010
    ..found that the negative regulators of proinflammatory signaling, such as the zinc-finger ubiquitin-modifying enzyme A20 and suppressor of cytokine signaling 1 (SOCS1), play critical roles in limiting the immunostimulatory potency of ..