A20

Summary

Gene Symbol: A20
Description: tumor necrosis factor, alpha-induced protein 3
Alias: A20, OTUD7C, TNFA1P2, OTU domain-containing protein 7C, TNF alpha-induced protein 3, tumor necrosis factor alpha-induced protein 3, tumor necrosis factor inducible protein A20, zinc finger protein A20
Species: human

Top Publications

  1. ncbi De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
    Ingrid E Wertz
    Department of Molecular Oncology, School of Medicine, University of California, Davis, Davis, California 95616, USA
    Nature 430:694-9. 2004
  2. ncbi Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
    Robert R Graham
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Nat Genet 40:1059-61. 2008
  3. ncbi Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
    E G Lee
    Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, MC 6084, Chicago, IL 60637, USA
    Science 289:2350-4. 2000
  4. ncbi Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
  5. ncbi The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein
    A W Opipari
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    J Biol Chem 265:14705-8. 1990
  6. ncbi The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population
    Kenichi Shimane
    Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 62:574-9. 2010
  7. ncbi TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas
    Keiichiro Honma
    Aichi Cancer Center Research Institute, Nagoya, Japan
    Blood 114:2467-75. 2009
  8. ncbi Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays
    Joanne Gallagher
    The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    FEBS Lett 551:8-12. 2003
  9. ncbi A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism
    J T Cooper
    Sandoz Center for Immunobiology, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 271:18068-73. 1996
  10. ncbi Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20
    Su Chang Lin
    Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Mol Biol 376:526-40. 2008

Research Grants

  1. IDENTIFICATION OF NATURALLY PROCESSED SMANSONI PEPTIDES
    Philip Loverde; Fiscal Year: 2001
  2. VACCINIA DNA REPLICATION
    Paula Traktman; Fiscal Year: 2007
  3. TNFAIP3 (A20) and Susceptibility to Systemic Lupus Erythematosus
    Patrick M Gaffney; Fiscal Year: 2010
  4. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2003
  5. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2006
  6. Immature intestinal NF-kB regulation, probiotics, and necrotizing enterocolitis
    Erika C Claud; Fiscal Year: 2010
  7. Immature intestinal NF-kB regulation, probiotics, and necrotizing enterocolitis
    Erika C Claud; Fiscal Year: 2010
  8. MEDIATORS AND MODIFIERS OF NF-kappaB IN INSULIN RESISTANCE
    Steven Shoelson; Fiscal Year: 2007
  9. CD1 AND BCR/Fc RECEPTOR TARGETED LIGAND
    Grant Yeaman; Fiscal Year: 2001
  10. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2009

Detail Information

Publications182 found, 100 shown here

  1. ncbi De-ubiquitination and ubiquitin ligase domains of A20 downregulate NF-kappaB signalling
    Ingrid E Wertz
    Department of Molecular Oncology, School of Medicine, University of California, Davis, Davis, California 95616, USA
    Nature 430:694-9. 2004
    ..to downregulate NF-kappaB transcriptional activity results in chronic inflammation and cell death, as observed in A20-deficient mice. A20 is a potent inhibitor of NF-kappaB signalling, but its mechanism of action is unknown...
  2. ncbi Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus
    Robert R Graham
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
    Nat Genet 40:1059-61. 2008
    ..These results establish that variants near TNFAIP3 contribute to differential risk of SLE and RA...
  3. ncbi Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice
    E G Lee
    Department of Medicine, The University of Chicago, 5841 South Maryland Avenue, MC 6084, Chicago, IL 60637, USA
    Science 289:2350-4. 2000
    b>A20 is a cytoplasmic zinc finger protein that inhibits nuclear factor kappaB (NF-kappaB) activity and tumor necrosis factor (TNF)-mediated programmed cell death (PCD)...
  4. ncbi Common variants at CD40 and other loci confer risk of rheumatoid arthritis
    Soumya Raychaudhuri
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 40:1216-23. 2008
    ..1 x 10(-7) overall), CDK6 (rs42041, P = 0.010 replication, P = 4.0 x 10(-6) overall), PRKCQ (rs4750316, P = 0.0078 replication, P = 4.4 x 10(-6) overall), and KIF5A-PIP4K2C (rs1678542, P = 0.0026 replication, P = 8.8 x 10(-8) overall)...
  5. ncbi The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein
    A W Opipari
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    J Biol Chem 265:14705-8. 1990
    We have previously identified in endothelial cells a gene product designated A20, that is rapidly and profoundly induced by tumor necrosis factor alpha (Dixit, V. M., Green, S., Sarma, V., Holzman, L. B., Wolf, F. W., O'Rourke, K...
  6. ncbi The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population
    Kenichi Shimane
    Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Arthritis Rheum 62:574-9. 2010
    ..The aim of this study was to assess the role of TNFAIP3 in the development of SLE and RA in Japanese subjects...
  7. ncbi TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas
    Keiichiro Honma
    Aichi Cancer Center Research Institute, Nagoya, Japan
    Blood 114:2467-75. 2009
    ..shown that chromosome 6q was frequently deleted in ocular marginal zone B-cell lymphoma and identified TNFAIP3/A20, a negative regulator of NF-kappaB pathways, as the primary target for 6q deletion...
  8. ncbi Identification of Naf1/ABIN-1 among TNF-alpha-induced expressed genes in human synoviocytes using oligonucleotide microarrays
    Joanne Gallagher
    The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, Dublin 4, Ireland
    FEBS Lett 551:8-12. 2003
    ..The regulation of Nef-associated factor-1 (Naf1), an A20-binding, nuclear factor kappa B (NFkappaB) inhibitory protein was probed further given its putative role as an ..
  9. ncbi A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism
    J T Cooper
    Sandoz Center for Immunobiology, Deaconess Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 271:18068-73. 1996
    The A20 gene product is a novel zinc finger protein originally described as a tumor necrosis factor alpha (TNF)-inducible early response gene in human umbilical vein endothelial cells (HUVEC)...
  10. ncbi Molecular basis for the unique deubiquitinating activity of the NF-kappaB inhibitor A20
    Su Chang Lin
    Department of Biochemistry, Weill Medical College of Cornell University, 1300 York Avenue, New York, NY 10021, USA
    J Mol Biol 376:526-40. 2008
    ..b>A20 is a specific feedback inhibitor of NF-kappaB activation in these pathways that possesses dual ubiquitin-editing ..
  11. ncbi The NF-{kappa}B negative regulator TNFAIP3 (A20) is inactivated by somatic mutations and genomic deletions in marginal zone lymphomas
    Urban Novak
    Institute for Cancer Genetics, Departments of Pathology and Genetics and Development, and The Herbert Irving Comprehensive Cancer Center, Columbia University, New York, NY 10032, USA
    Blood 113:4918-21. 2009
    ..deletions of the chromosomal band 6q23, involving the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20) gene, a negative regulator of NF-kappaB, were described in ocular adnexal MZL, suggesting a role for A20 as a ..
  12. ncbi Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus
    Stacy L Musone
    Cardiovascular Research Institute, Department of Medicine, University of California San Francisco, San Francisco, California 94143, USA
    Nat Genet 40:1062-4. 2008
    The TNFAIP3 (tumor necrosis factor alpha-induced protein 3) gene encodes a ubiquitin editing enzyme, A20, that restricts NF-kappaB-dependent signaling and prevents inflammation...
  13. ncbi Negative regulation of the retinoic acid-inducible gene I-induced antiviral state by the ubiquitin-editing protein A20
    Rongtuan Lin
    Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, and Department of Microbiology, McGill University, Montreal, Quebec H3T 1E2, Canada
    J Biol Chem 281:2095-103. 2006
    ..In the present study, we demonstrate that the NF-kappaB-inducible, anti-apoptotic protein A20 efficiently blocks RIG-I-mediated activation of NF-kappaB-, IRF-3-, and IRF-7-dependent promoters but only weakly ..
  14. ncbi ABIN-1 is a ubiquitin sensor that restricts cell death and sustains embryonic development
    Shigeru Oshima
    Department of Medicine, University of California at San Francisco, 513 Parnassus Avenue, S 1057, San Francisco, California 94143 0451, USA
    Nature 457:906-9. 2009
    ..ABIN-1 (A20 binding and inhibitor of NF-kappaB) is a novel protein that is thought to inhibit NF-kappaB signalling...
  15. ncbi African-derived genetic polymorphisms in TNFAIP3 mediate risk for autoimmunity
    James P Lodolce
    Department of Medicine, University of Chicago, Chicago, IL 60612, USA
    J Immunol 184:7001-9. 2010
    ..This is the first report of an association between TNFAIP3 polymorphisms and autoimmunity in African-Americans...
  16. ncbi Frequent inactivation of A20 in B-cell lymphomas
    Motohiro Kato
    Cancer Genomics Project, Department of Pediatrics, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Nature 459:712-6. 2009
    b>A20 is a negative regulator of the NF-kappaB pathway and was initially identified as being rapidly induced after tumour-necrosis factor-alpha stimulation...
  17. ncbi The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6
    K Heyninck
    Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology and University of Ghent, Belgium
    FEBS Lett 442:147-50. 1999
    The zinc finger protein A20 is encoded by an immediate early response gene whose expression is induced by different inflammatory stimuli, including interleukin-1 (IL-1)...
  18. ncbi Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations
    J S Bates
    Oklahoma Medical Research Foundation, Arthritis and Immunology Research Program, Oklahoma City, OK 73104, USA
    Genes Immun 10:470-7. 2009
    TNFAIP3 encodes the ubiquitin-modifying enzyme, A20, a key regulator of inflammatory signaling pathways. We previously reported association between TNFAIP3 variants and systemic lupus erythematosus (SLE)...
  19. ncbi The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation
    H Y Song
    Tularik, Inc, South San Francisco, CA 94080, USA
    Proc Natl Acad Sci U S A 93:6721-5. 1996
    ..Here we show that TRAF1 and TRAF2 interact with A20, a zinc finger protein, whose expression is induced by agents that activate NF-kappaB...
  20. ncbi A20 is an early responding negative regulator of Toll-like receptor 5 signalling in intestinal epithelial cells during inflammation
    N Oshima
    Department of Internal Medicine II, Shimane University School of Medicine, Izumo, Shimane, Japan
    Clin Exp Immunol 159:185-98. 2010
    ..receptor (TLR)-mediated inflammatory responses and restore immune system balance, including the zinc-finger protein A20, a negative regulator of TLR signalling that inhibits nuclear factor kappa B (NF-kappaB) activity...
  21. ncbi Neuroprotective effect of A20 on TNF-induced postischemic apoptosis
    Luyang Yu
    Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Room 901, Cell Biology Building, No 320 Yueyang Road, Shanghai 200031, China
    Neurochem Res 31:21-32. 2006
    ..TNF is critically involved in such neuronal apoptosis mediated by caspase pathways. A20 can inhibit TNF-induced apoptosis in many cell types...
  22. ncbi A20/TNFAIP3, a new estrogen-regulated gene that confers tamoxifen resistance in breast cancer cells
    J A Vendrell
    CNRS UMR 5160, Centre de Pharmacologie et Biotechnologie pour la Santé, Faculte de Pharmacie, Montpellier, France
    Oncogene 26:4656-67. 2007
    The zinc-finger protein A20/TNFAIP3, an inhibitor of nuclear factor-kappaB (NF-kappaB) activation, has been shown to protect MCF-7 breast carcinoma cells from TNFalpha-induced apoptosis...
  23. ncbi Tag polymorphisms at the A20 (TNFAIP3) locus are associated with lower gene expression and increased risk of coronary artery disease in type 2 diabetes
    Watip Boonyasrisawat
    Section on Genetics and Epidemiology, Joslin Diabetes Center, One Joslin Place, Boston, MA 02215, USA
    Diabetes 56:499-505. 2007
    b>A20 or tumor necrosis factor (TNF)-induced protein 3 (TNFAIP3) is a negative regulator of nuclear factor-kappaB (NF-kappaB)...
  24. ncbi Two independent alleles at 6q23 associated with risk of rheumatoid arthritis
    Robert M Plenge
    Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts 02142, USA
    Nat Genet 39:1477-82. 2007
    ..We show that these two SNP associations are statistically independent, are each reproducible in the comparison of our data and WTCCC data, and define risk and protective haplotypes for rheumatoid arthritis at 6q23...
  25. ncbi TNFAIP3 is the target gene of chromosome band 6q23.3-q24.1 loss in ocular adnexal marginal zone B cell lymphoma
    Keiichiro Honma
    Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan
    Genes Chromosomes Cancer 47:1-7. 2008
    ..TNFAIP3 is an inhibitor of NF-kB signaling so that loss of this gene may play an important role in lymphomagenesis and suggests that TNFAIP3 may act as a tumor suppressor gene in ocular adnexal marginal zone B cell lymphoma...
  26. ncbi A20 is overexpressed in glioma cells and may serve as a potential therapeutic target
    Qingdong Guo
    The Fourth Military Medical University, Xijing Hospital, Department of Neurosurgery, Xi an 710032, China
    Expert Opin Ther Targets 13:733-41. 2009
    b>A20 is a TNF-inducible primary response gene, which has been found to have antiapoptotic function in several cancer cells...
  27. ncbi T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20
    Beatrice Coornaert
    Department of Molecular Biology, Ghent University, B 9052 Ghent, Belgium
    Nat Immunol 9:263-71. 2008
    ..Here we show that T cell antigen receptor stimulation induced recruitment of the NF-kappaB inhibitor A20 into a complex of MALT1 and the adaptor protein Bcl-10, leading to MALT1-mediated processing of A20...
  28. ncbi Association of TNFAIP3 polymorphism with susceptibility to systemic lupus erythematosus in a Japanese population
    Aya Kawasaki
    Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba 305 8575, Japan
    J Biomed Biotechnol 2010:207578. 2010
    ..013). These results indicated that TNFAIP3 is a susceptibility gene to SLE both in the Caucasian and Asian populations...
  29. ncbi The ubiquitin-editing enzyme A20 requires RNF11 to downregulate NF-kappaB signalling
    Noula Shembade
    Department of Microbiology and Immunology, Sylvester Comprehensive Cancer Center, Miller School of Medicine, The University of Miami, Miami, FL 33136, USA
    EMBO J 28:513-22. 2009
    ..RNF11 interacted with the NF-kappaB inhibitor A20 and its regulatory protein TAX1BP1 in a stimulus-dependent manner...
  30. ncbi TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma
    Roland Schmitz
    Institute of Cell Biology Cancer Research, Medical School, University of Duisburg Essen, 45122 Essen, Germany
    J Exp Med 206:981-9. 2009
    ..NF-kappaB activation through various stimuli is negatively regulated by the zinc finger protein A20. To determine whether A20 contributes to the pathogenesis of cHL, we sequenced TNFAIP3, encoding A20, in ..
  31. ncbi A20 protects endothelial cells from TNF-, Fas-, and NK-mediated cell death by inhibiting caspase 8 activation
    Soizic Daniel
    Department of Surgery and Medicine, 99 Brookline Ave, Boston MA 02215, USA
    Blood 104:2376-84. 2004
    b>A20 is a stress response gene in endothelial cells (ECs)...
  32. ncbi The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN
    K Heyninck
    Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology, University of Ghent, B 9000 Ghent, Belgium
    J Cell Biol 145:1471-82. 1999
    The zinc finger protein A20 is a tumor necrosis factor (TNF)- and interleukin 1 (IL-1)-inducible protein that negatively regulates nuclear factor-kappa B (NF-kappaB)-dependent gene expression...
  33. ncbi The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases
    D De Valck
    Department of Molecular Biology, Flanders Interuniversity Institute for Biotechnology and University of Gent, Belgium
    Oncogene 18:4182-90. 1999
    b>A20 is a Cys2/Cys2 zinc finger protein which is induced by a variety of inflammatory stimuli and which has been characterized as an inhibitor of cell death by a yet unknown mechanism...
  34. ncbi Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin
    V M Dixit
    Department of Pathology, University of Michigan Medical School, Ann Arbor 48109
    J Biol Chem 265:2973-8. 1990
    ..Interleukin-1 beta and lipopolysaccharide are also potent inducers. Nuclear run-on studies revealed that in most cases induction by TNF is mediated largely at the transcriptional level...
  35. ncbi A20 takes on tumors: tumor suppression by an ubiquitin-editing enzyme
    Barbara A Malynn
    Program in Biomedical Sciences, Program in Biological Sciences, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 206:977-80. 2009
    ..A new study identifies somatic mutations in TNFAIP3, the gene encoding the NF-kappaB inhibitor A20, in Hodgkin lymphomas and primary mediastinal lymphomas...
  36. ncbi A20, an inhibitor of cell death, self-associates by its zinc finger domain
    D De Valck
    Laboratory of Molecular Biology, University of Gent, Belgium
    FEBS Lett 384:61-4. 1996
    b>A20 is a primary response gene which is induced after monocyte adherence or cytokine stimulation of a variety of cells...
  37. ncbi A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins
    D De Valck
    Laboratory of Molecular Biology, Flanders Interuniversity Institute for Biotechnology, University of Ghent, K L Ledeganckstraat 35, Ghent, B 9000, Belgium
    Biochem Biophys Res Commun 238:590-4. 1997
    The A20 protein, which belongs to a class of Cys2/Cys2 zinc finger proteins, has been characterized as an inhibitor of NF-kappaB activation...
  38. ncbi Combined expression of A1 and A20 achieves optimal protection of renal proximal tubular epithelial cells
    Uta Kunter
    Division of Vascular Surgery, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Kidney Int 68:1520-32. 2005
    ..In endothelial cells, the Bcl family member A1 and the zinc finger protein A20 have redundant and dual antiapoptotic and anti-inflammatory effects...
  39. ncbi 14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules
    C Vincenz
    Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA
    J Biol Chem 271:20029-34. 1996
    b>A20, a novel zinc finger protein, is an inhibitor of tumor necrosis factor-induced apoptosis. The mechanism by which A20 exerts its protective effect is currently unknown...
  40. ncbi Strain-ecotype specificity in Sinorhizobium meliloti-Medicago truncatula symbiosis is correlated to succinoglycan oligosaccharide structure
    Senay Simsek
    Whistler Center for Carbohydrate Research, Purdue University, 745 Agriculture Mall Drive, West Lafayette, IN 47907 2009, USA
    J Bacteriol 189:7733-40. 2007
    ..meliloti Rm41 and NRG247 are Fix+ (compatible) on M. truncatula A20 and Fix- (incompatible) on M. truncatula A17, the Fix phenotypes are reversed with S...
  41. ncbi Fas-mediated activation of phospholipase D is coupled to the stimulation of phosphatidylcholine-specific phospholipase C in A20 cells
    J S Han
    College of Medicine, Hanyang University, Seoul, 133 791, Korea
    Arch Biochem Biophys 367:233-9. 1999
    The activation of phospholipase D in murine B cell lymphoma A20 cells treated with anti-Fas monoclonal antibody has been investigated. Fas cross-linking resulted in a both dose- and time-dependent increases in phospholipase D activity...
  42. ncbi Myosin light chain-activating phosphorylation sites are required for oogenesis in Drosophila
    P Jordan
    Centre de Genetique Moleculaire, 91198 Gif sur Yvette, France
    J Cell Biol 139:1805-19. 1997
    ..In addition, numerous aggregates of myosin heavy chain accumulate in the sqh null cells. Mutant sqh transgene sqh-A20, A21 in which both serine-21 and threonine-20 have been replaced by alanines behaves in most respects identically ..
  43. ncbi Associations among serum lipoprotein(a) levels, apolipoprotein(a) phenotypes, and myocardial infarction in patients with extremely low and high levels of serum lipoprotein(a)
    K Saku
    Department of Internal Medicine, Fukuoka University School of Medicine, Japan
    Jpn Circ J 63:659-65. 1999
    ..higher percentages of smaller isoforms (A1-A4, A5-A9) and decreasingly lower percentages of large isoforms (A10-A20, A21-A25) compared to Group I. An apparent inverse relationship existed between Lp(a) and the apo(a) phenotype...
  44. ncbi Mengovirus and encephalomyocarditis virus poly(C) tract lengths can affect virus growth in murine cell culture
    L R Martin
    Institute for Molecular Virology and Department of Biochemistry, University of Wisconsin Madison, Madison, Wisconsin 53706, USA
    J Virol 74:3074-81. 2000
    ..Replication and cytopathic studies with four hematopoietically derived cell lines (CH2B, RAW 264.7, A20.J, and P815) and two murine fibroblast cell lines [L929 and L(Y)] demonstrated that several of these cell types ..
  45. ncbi An essential role of antigen-presenting cell/T-helper type 1 cell-cell interactions in draining lymph node during complete eradication of class II-negative tumor tissue by T-helper type 1 cell therapy
    Kenji Chamoto
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo 060 0815, Japan
    Cancer Res 66:1809-17. 2006
    ..of ovalbumin (OVA)-specific T helper type 1 (Th1) cells into mice bearing MHC class II+ OVA-expressing tumor cells (A20-OVA) causes complete tumor rejection...
  46. ncbi The specific interaction of helper T cells and antigen-presenting B cells. IV. Membrane and cytoskeletal reorganizations in the bound T cell as a function of antigen dose
    A Kupfer
    Department of Biology, University of California at San Diego, La Jolla 92093
    J Exp Med 170:1697-713. 1989
    ..The Th cell was directed to a peptide fragment of the Ag OVA in the context of IAd. The B-APC was the transfected A20 B hybridoma cell A20-HL, bearing on its surface a surface Ig specific for the hapten TNP, and pulsed with different ..
  47. ncbi Metaphit-induced audiogenic seizures in mice: II. Studies on N-methyl-D-aspartic acid, GABA, and sodium channel receptors and on the disposition of metaphit in the brain
    M N Lipovac
    Division of Neurochemistry, Nathan S Kline Institute, Orangeburg, New York
    Epilepsia 34:211-9. 1993
    ..complex, for [3H]muscimol on the gamma-aminobutyric acid (GABA) receptor complex, and for [3H]batrachotoxinin A20-alpha-benzoate on the voltage-dependent sodium channel...
  48. ncbi ABINs: A20 binding inhibitors of NF-kappa B and apoptosis signaling
    Lynn Verstrepen
    Department of Biomedical Molecular Biology, Ghent University, Technologiepark 927, B 9052 Zwijnaarde, Belgium
    Biochem Pharmacol 78:105-14. 2009
    ..ABIN-1, ABIN-2, ABIN-3) that bind the ubiquitin-editing nuclear factor-kappaB (NF-kappaB) inhibitor protein A20 and which show limited sequence homology...
  49. ncbi The inhibitor ABIN-2 disrupts the interaction of receptor-interacting protein with the kinase subunit IKKgamma to block activation of the transcription factor NF-kappaB and potentiate apoptosis
    Wei Kuang Liu
    Institute of Microbiology and Immunology, National Yang Ming University, 155, Sec 2, Li Rong Street, Pei Tou, Taipei 11211, Taiwan, Republic of China
    Biochem J 378:867-76. 2004
    ..We and others have previously identified the protein ABIN-2 (A20 binding inhibitor of NF-kappaB 2) as an inhibitor of NF-kappaB activation...
  50. ncbi A single gene, AIN, in Medicago truncatula mediates a hypersensitive response to both bluegreen aphid and pea aphid, but confers resistance only to bluegreen aphid
    John P Klingler
    Commonwealth Scientific and Industrial Research Organisation Entomology, Private Bag 5, Wembley, WA 6913, Australia
    J Exp Bot 60:4115-27. 2009
    ..kondoi Shinji) and the pea aphid (PA, Acyrthosiphon pisum (Harris)) were analysed using reference genotypes A17 and A20, their F(2) progeny and recombinant inbred lines...
  51. ncbi Identification of an I-Ed-restricted T-cell epitope of Escherichia coli outer membrane protein F
    Kristina M Williams
    Center for Food Safety and Applied Nutrition, Immunobiology Branch, Food and Drug Administration, 8301 Muirkirk Road, Laurel, MD 20708, USA
    Infect Immun 72:3907-13. 2004
    ..Class II(+) mouse lymphoma (A20) cells, but not class II(-) mouse mastocytoma (P815) cells, supported IL-2 secretion of hybridomas when substituted ..
  52. ncbi Use of persistent infections with vaccinia virus recombinants to introduce alterations in foreign proteins: an application to HIV-1 env protein
    M Esteban
    Department of Cell and Molecular Biology, CSIC, Madrid, Spain
    Virus Res 46:45-56. 1996
    ..of use in studies of their biological functions--we established a persistent infection on a B-lymphoma cell line (A20.2J) with vaccinia virus (VV) recombinants...
  53. ncbi Dynamics of molecules involved in antigen presentation: effects of fixation
    B G Barisas
    Department of Chemistry, Colorado State University, Fort Collins 80523, USA
    Mol Immunol 36:701-8. 1999
    ..Lateral and rotational dynamics of the MHC class II antigen I-Ad on A20 cells fixed with various concentrations of paraformaldehyde were examined by fluorescence photobleaching recovery ..
  54. ncbi Graft-vs-leukemia activity and graft-vs-host disease induced by allogeneic Th1- and Th2-type CD4+ T cells in mice
    M Zeis
    2nd Department of Internal Medicine, University of Kiel, Kiel, Germany
    Hematol J 2:136-44. 2001
    ..Therefore, separation of GVL- and GVH-reactions is a long-standing goal of experimental studies dealing with allogeneic transplantation of hematopoietic stem cells...
  55. ncbi The cytosolic free Ca2+ in ectromelia (mousepox) virus stimulated cytotoxic T lymphocytes
    F N Toka
    Department of Microbiology and Immunology, Faculty of Veterinary Medicine, Warsaw Agricultural University SGGW, Poland
    Viral Immunol 9:159-167. 1996
    ..the activation of ectromelia virus (EV)-specific cytotoxic T lymphocytes (CTL) upon stimulation with EV-sensitized (A20) target cells or concanavalin A (Con A). The CTL originated from mice previously infected with EV...
  56. ncbi Structural and mutational studies of the recognition of the arginine tRNA-specific major identity element, A20, by arginyl-tRNA synthetase
    A Shimada
    Department of Biophysics and Biochemistry, Graduate School of Science, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Proc Natl Acad Sci U S A 98:13537-42. 2001
    Arginyl-tRNA synthetase (ArgRS) recognizes two major identity elements of tRNA(Arg): A20, located at the outside corner of the L-shaped tRNA, and C35, the second letter of the anticodon...
  57. ncbi Arsenite-induced thymus atrophy is mediated by cell cycle arrest: a characteristic downregulation of E2F-related genes revealed by a microarray approach
    Keiko Nohara
    Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba 305 8506, Japan
    Toxicol Sci 101:226-38. 2008
    ..The same genes were also downregulated when mouse B-cell lymphoma A20 cells were exposed to arsenite...
  58. ncbi A stress-associated protein containing A20/AN1 zing-finger domains expressed in Medicago truncatula seeds
    Christine Gimeno-Gilles
    University of Angers, UMR 1191 Physiologie Moléculaire des Semences, IFR 149 QUASAV, 2 Boulevard Lavoisier, Angers Cedex 01, France
    Plant Physiol Biochem 49:303-10. 2011
    ..MtSAP1 is the first gene encoding a SAP with A20 and AN1 zinc-finger domains characterized in M. truncatula...
  59. ncbi A ten-residue domain (Y11-A20) in the NH2-terminus modulates membrane association of annexin A7
    Avinash Chander
    Department of Pediatrics, Stony Brook University School of Medicine, Stony Brook, NY 11794 8111, USA
    Biochim Biophys Acta 1761:775-84. 2006
    ..For binding and fusion of biological membranes, the 10-29-residue domain may be required although the annexin A7 properties are primarily modulated through the Y(11)-A(20) domain...
  60. ncbi Role of ICAM-1 in antigen presentation demonstrated by ICAM-1 defective mutants
    L H Dang
    Division of Lymphocyte Biology, Dana Farber Cancer Institute, Boston, MA 02115
    J Immunol 144:4082-91. 1990
    We report a methodology for selecting APC with mutations that have impaired their ability to present Ag to T cells. A20 B lymphoblastoid cells were mutagenized and then repeatedly cocultured with murine T-T hybridomas in the presence of ..
  61. ncbi Differential expression and function of A20 and TRAF1 in Hodgkin lymphoma and anaplastic large cell lymphoma and their induction by CD30 stimulation
    Horst Dürkop
    Institut fur Pathologie, UK Benjamin Franklin, Freie Universitat Berlin, Germany
    J Pathol 200:229-39. 2003
    b>A20 and TRAF1 are two anti-apoptotic components of the intracellular signalling pathway of the tumour necrosis factor receptor (TNFR) family. Induction of apoptosis seems to be a main function of these receptors...
  62. ncbi Ubiquitin-binding domains
    James H Hurley
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, U S Department of Health and Human Services, Bethesda, MD 20892, USA
    Biochem J 399:361-72. 2006
    ..of this group has expanded rapidly and now includes at least sixteen domains: UBA, UIM, MIU, DUIM, CUE, GAT, NZF, A20 ZnF, UBP ZnF, UBZ, Ubc, UEV, UBM, GLUE, Jab1/MPN and PFU...
  63. ncbi Tumor necrosis factor-alpha-induced protein 3 as a putative regulator of nuclear factor-kappaB-mediated resistance to O6-alkylating agents in human glioblastomas
    Markus Bredel
    Division of Oncology, Center for Clinical Sciences Research, Institute for Computational and Mathematical Engineering, Department of Neurosurgery, Stanford University School of Medicine, Stanford, CA 94305 5151, USA
    J Clin Oncol 24:274-87. 2006
    ..Pre-existing and acquired drug resistance are major obstacles to the successful treatment of glioblastomas...
  64. ncbi Endotoxin tolerance impairs IL-1 receptor-associated kinase (IRAK) 4 and TGF-beta-activated kinase 1 activation, K63-linked polyubiquitination and assembly of IRAK1, TNF receptor-associated factor 6, and IkappaB kinase gamma and increases A20 expression
    Yanbao Xiong
    Department of Microbiology and Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Biol Chem 286:7905-16. 2011
    ..Deficiencies in these signaling events in LPS-tolerant cells coincided with increased expression of A20, an essential deubiquitination enzyme, and sustained A20-IRAK1 associations...
  65. ncbi Elevated amount of Toll-like receptor 4 mRNA in bronchial epithelial cells is associated with airway inflammation in horses with recurrent airway obstruction
    Annerose Berndt
    Pulmonary Laboratory, Department of Large Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University East Lansing, MI 48824, USA
    Am J Physiol Lung Cell Mol Physiol 292:L936-43. 2007
    ..The zinc finger protein A20 negatively regulates this pathway...
  66. ncbi Oral administration of a soluble 1-3, 1-6 beta-glucan during prophylactic survivin peptide vaccination diminishes growth of a B cell lymphoma in mice
    Ulf Harnack
    Medical Clinic of Oncology and Hematology, Charite Universitatsmedizin Berlin, Campus Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Int Immunopharmacol 9:1298-303. 2009
    ..a soluble yeast-derived beta-(1-3), (1-6)-D-glucan on prophylactic peptide vaccination against the B cell lymphoma A20 in syngeneic Balb/c mice...
  67. ncbi Effects on brain edema of crystalloid and albumin fluid resuscitation after brain trauma and hemorrhage in the rat
    Mårten Jungner
    Department of Anesthesiology and Intensive Care, Lund University and Lund University Hospital, Lund, Sweden
    Anesthesiology 112:1194-203. 2010
    ..To test this hypothesis, the authors compared groups resuscitated with either colloid or crystalloid...
  68. ncbi Zinc and inflammatory/immune response in aging
    Sonya Vasto
    Immunosenescence Unit, Department of Pathobiology and Biomedical Methodologies, Palermo University, Corso Tukory 211, 90134 Palermo, Italy
    Ann N Y Acad Sci 1100:111-22. 2007
    ..of NF-kappaB have been attributed to the suppression of phosphorylation and degradation of the inhibitory proteins (A20) that normally sequester it in the cytoplasm...
  69. ncbi Computer simulations to identify in polyproteins of FMDV OK1 and A12 strains putative nonapeptides with amino acid motifs for binding to BoLA class I A11 and A20 haplotype molecules
    Y Becker
    Department of Molecular Virology, Faculty of Medicine, Hebrew University of Jerusalem, Israel
    Virus Genes 14:123-9. 1997
    ..for the availability of putative proteasome-generated nonapeptides with motifs reported for BoLA class I A11 and A20 haplotypes...
  70. ncbi Changes in gene expression in beta cells after islet isolation and transplantation using laser-capture microdissection
    Y B Ahn
    Section on Islet Transplantation and Cell Biology, Research Division, Joslin Diabetes Center and the Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Diabetologia 50:334-42. 2007
    ..In addition, hyperglycaemia after islet transplantation can compromise beta cell function. The aim of this experiment was to evaluate changes in gene expression in endogenous islets using laser-capture microdissection (LCM)...
  71. ncbi Expression of human complement receptor 2 (CR2, CD21) in Cr2-/- mice restores humoral immune function
    K J Marchbank
    Division of Rheumatology, Departments of Medicine and Immunology, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Immunol 165:2354-61. 2000
    ..Transfection of P1-5 into the mouse A20 B cell line confirmed that it would direct expression of the hCR2 protein in mouse B cells...
  72. ncbi Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis
    Nina A Daha
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 60:1255-60. 2009
    ....
  73. ncbi Degradation of complement 3 by streptococcal pyrogenic exotoxin B inhibits complement activation and neutrophil opsonophagocytosis
    Chih Feng Kuo
    Department of Nursing, I Shou University, Kaohsiung County, Taiwan
    Infect Immun 76:1163-9. 2008
    ..SPE B-treated, but not C192S-treated, serum also impaired opsonization of C3 fragments on the surface of GAS strain A20. Moreover, the amount of C3 fragments on the A20 cell surface, a SPE B-producing strain, was less than that on its ..
  74. ncbi TRAF1 polymorphisms associated with rheumatoid arthritis susceptibility in Asians and in Caucasians
    Tae Un Han
    Korea Advanced Institute of Science and Technology, Daejeon, South Korea
    Arthritis Rheum 60:2577-84. 2009
    ..The aim of this study was to evaluate the RA-associated loci by genotyping previously reported SNPs and additional tag SNPs in a Korean population...
  75. ncbi Intragraft gene expression profile associated with the induction of tolerance
    Tomoko Doki
    Department of Cardiothoracic Surgery Research, Transplantation Biology Research Laboratory, Childrens Hospital Los Angeles, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    BMC Immunol 9:5. 2008
    ..The mechanisms by which tolerance is achieved include systemic changes such as clonal deletion and/or anergy. Intragraft changes that occur during the early stages of tolerance induction have not been characterized...
  76. ncbi Isolation and enzymatic characterization of lamjapin, the first ribosome-inactivating protein from cryptogamic algal plant (Laminaria japonica A)
    Ren Shui Liu
    State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, China
    Eur J Biochem 269:4746-52. 2002
    ..Lamjapin can deadenylate specifically at the site A20 of the synthetic oligoribonucleotide (35-mer) substrate that mimics the sarcin/ricin domain (SRD) of rat ribosomal ..
  77. ncbi Inhibition of vaccinia virus replication by peptide aptamers
    Laurent Saccucci
    Institut de Recherches Biomédicales des Armées, CRSSA Emile Pardé, Grenoble, France
    Antiviral Res 82:134-40. 2009
    b>A20 protein is a major component of the vaccinia virus replication complex. It binds to the DNA polymerase E9, the uracil DNA glycosylase D4 and the primase/helicase D5, three proteins that are essential for viral DNA synthesis...
  78. ncbi A discriminating messenger RNA signature for bipolar disorder formed by an aberrant expression of inflammatory genes in monocytes
    Roos C Padmos
    Department of Immunology, Erasmus Medical Center, 3000 DR Rotterdam, The Netherlands
    Arch Gen Psychiatry 65:395-407. 2008
    ..Mood disturbances are associated with an activated inflammatory response system...
  79. ncbi Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma
    Mara Compagno
    Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York 10032, USA
    Nature 459:717-21. 2009
    ..a smaller fraction of GCB-DLBCL carry somatic mutations in multiple genes, including negative (TNFAIP3, also called A20) and positive (CARD11, TRAF2, TRAF5, MAP3K7 (TAK1) and TNFRSF11A (RANK)) regulators of NF-kappaB...
  80. ncbi Potentiation of tumor eradication by adoptive immunotherapy with T-cell receptor gene-transduced T-helper type 1 cells
    Kenji Chamoto
    Division of Immunoregulation, Section of Disease Control, Institute for Genetic Medicine, Hokkaido University, Sapporo, Japan
    Cancer Res 64:386-90. 2004
    ..10 produce IFN-gamma but not interleukin-4 in response to stimulation with OVA(323-339) peptides or A20 B lymphoma (A20-OVA) cells expressing OVA as a model tumor antigen...
  81. ncbi SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes
    C L Manthey
    Department of Biology, Amgen, Inc, Boulder, Colorado 80301, USA
    J Leukoc Biol 64:409-17. 1998
    ..Of these, genes encoding interferon-induced gene 15, neuroleukin, radiation-inducible immediate-early gene-1, A20, IL-1beta, and superoxide dismutase were suppressed >50% by SB202190...
  82. ncbi Distribution of ammonia-oxidizing bacteria in sewage activated sludge: analysis based on 16S rDNA sequence
    T Limpiyakorn
    Department of Urban Engineering, The University of Tokyo, Tokyo 113 8656, Japan
    Water Sci Technol 50:9-14. 2004
    ..The systems were different in the treatment process configuration: anaerobic/anoxic/aerobic (A20), anaerobic/aerobic (AO), and conventional activated sludge (AS) processes...
  83. ncbi Purification and properties of three cellobiases from Aspergillus niger A20
    M A Abdel Naby
    Department of Chemistry of Natural and Microbial Products, National Research Centre, Dokki, Cairo, Egypt
    Appl Biochem Biotechnol 76:33-44. 1999
    Three cellobiases, here called cellobiase A, B, and C, from the culture filtrate of Aspergillus niger A20, were purified by precipitation with ammonium sulphate, gel filtration through Sephadex G-75, and column chromatography of DEAE-..
  84. ncbi Tumor suppressor A20 protects against cardiac hypertrophy and fibrosis by blocking transforming growth factor-beta-activated kinase 1-dependent signaling
    He Huang
    Department of Cardiology of Renmin Hospital, Wuhan University, Wuhan 430060, People s Republic of China
    Hypertension 56:232-9. 2010
    b>A20 or tumor necrosis factor-induced protein 3 is a negative regulator of nuclear factor kappaB signaling. A20 has been shown previously to attenuate cardiac hypertrophy in vitro and postmyocardial infarction remodeling in vivo...
  85. ncbi A20 inhibits human salivary adenoid cystic carcinoma cells invasion via blocking nuclear factor-kappaB activation
    Bin Zhang
    Department of Oral and Maxillofacial Surgery, Second Affiliated Hospital, Harbin Medical University, Harbin 150001, China
    Chin Med J (Engl) 120:1830-5. 2007
    A20, also known as tumor necrosis factor alpha induced protein 3 (TNFaip3), is a cytoplasmic zinc finger protein that inhibits nuclear factor kappa-B (NF-kappaB) activity and prevents tumor necrosis factor (TNF)-mediated programmed cell ..
  86. ncbi The A20 deubiquitinase activity negatively regulates LMP1 activation of IRF7
    Shunbin Ning
    Division of Hematology Oncology, Department of Medicine, Miller School of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL 33136, USA
    J Virol 84:6130-8. 2010
    b>A20 possesses both deubiquitinase (DUB) and ubiquitin E3 ligase activities that are required for termination of Toll-like receptor (TLR) signaling leading to NF-kappaB activation and for blockage of tumor necrosis factor (TNF)-induced ..
  87. ncbi Contribution of residue B5 to the folding and function of insulin and IGF-I: constraints and fine-tuning in the evolution of a protein family
    Youhei Sohma
    Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 285:5040-55. 2010
    ..Native insulin-related growth factor (IGF)-I has canonical cystines (A6-A11, A7-B7, and A20-B19) maintained by IGF-binding proteins; IGF-swap has alternative pairing (A7-A11, A6-B7, and A20-B19) and impaired ..
  88. ncbi B7-2 expression above a threshold elicits anti-tumor immunity as effective as interleukin-12 and prolongs survival in murine B-cell lymphoma
    Eva Pizzoferrato
    Department of Surgery, Hillman Cancer Center, University of Pittsburgh, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Int J Cancer 110:61-9. 2004
    ..expression of the costimulatory molecule, B7-2, leads to more effective anti-tumor immunity in vivo, the A20 murine model of B-cell lymphoma was used...
  89. ncbi Ubiquitin-editing enzyme A20 promotes tolerance to lipopolysaccharide in enterocytes
    Jin Wang
    Division of Pediatric Surgery, Childrens Hospital Los Angeles, Los Angeles, CA 90027, USA
    J Immunol 183:1384-92. 2009
    ..lasts 20-26 h, temporally coincides with LPS-induced expression of the anti-inflammatory ubiquitin-editing enzyme A20. Small interfering RNA silencing of A20 prevents tolerance, whereas ectopic expression of A20 blocks responses to ..
  90. ncbi In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder
    Camillo Palmieri
    Department of Experimental and Clinical Medicine, University of Catanzaro Magna Graecia, Catanzaro, Italy
    Blood 116:226-38. 2010
    ..Here, we report the in vivo targeting and growth inhibition of aggressive A20 murine B-cell lymphoma by idiotype-specific peptide pA20-36...
  91. ncbi Post-induction alfentanil reduces sevoflurane-associated emergence agitation in children undergoing an adenotonsillectomy
    J Y Kim
    Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine, Seoul, Korea
    Acta Anaesthesiol Scand 53:678-81. 2009
    ..The purpose of this study was to investigate the effect of alfentanil to prevent emergence agitation without delayed recovery after VIMA with sevoflurane in children undergoing an adenotonsillectomy...
  92. ncbi NF-kappaB activation and zinc finger protein A20 expression in mature dendritic cells derived from liver allografts undergoing acute rejection
    Ming Qing Xu
    Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
    World J Gastroenterol 9:1296-301. 2003
    To investigate the role of NF-kappaB activation and zinc finger protein A20 expression in the regulation of maturation of dendritic cells (DCs) derived from liver allografts undergoing acute rejection.
  93. ncbi Differential effects of Fas cross-linking on phospholipase D activation and related lipid metabolism in Fas-resistant A20 cells
    Si Young Lim
    Institute of Biomedical Science and Department of Biochemistry, College of Medicine, Hanyang University, Seoul 133 791, Korea
    Exp Mol Med 34:201-10. 2002
    b>A20 murine lymphoma cells undergoing Fas-mediated apoptosis showed increase in the activity of phospholipase D (PLD), which is involved in proliferative or mitogenic cellular responses...
  94. ncbi [Immuno-characterization of mouse model similar to human diffuse large B cell lymphoma]
    Fang Liu
    Department of Basic Medicine, Medical College, Foshan University of Science and Technology, Foshan 528000, Guangdong Province, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 18:655-9. 2010
    ..The experiments were divided into 3 groups including group 1 (BALB/c mice with tumor resulting from injection of A20 cells), group 2 (BALB/c mice without tumor formation resulting from injection of A20 cells) and group 3 (normal ..
  95. ncbi A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression
    Haley E Ramsey
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    Liver Transpl 15:1613-21. 2009
    The nuclear factor-kappaB inhibitory protein A20 demonstrates hepatoprotective abilities through combined antiapoptotic, anti-inflammatory, and pro-proliferative functions...
  96. ncbi Overexpression of p65/RelA potentiates curcumin-induced apoptosis in HCT116 human colon cancer cells
    Gavin P Collett
    Department of Surgery, Centre for Cancer Research and Cell Biology, Queen s University Belfast, Belfast BT12 6BJ, UK
    Carcinogenesis 27:1285-91. 2006
    ..in part by activation of NFkappaB anti-apoptotic target genes including X-linked inhibitor of apoptosis (XIAP), A20, bcl-xL and inhibition of sustained activation of c-Jun N-terminal kinase (JNK)...
  97. ncbi Role of nuclear factor-κB regulators TNFAIP3 and CARD11 in Middle Eastern diffuse large B-cell lymphoma
    Rong Bu
    Human Cancer Genomic Research, Research Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia
    Leuk Lymphoma 53:1971-7. 2012
    ....
  98. ncbi Comparison of bacterial community structures in two systems of a sewage treatment plant using PCR-DGGE analysis
    Abd El Latif Hesham
    State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    J Environ Sci (China) 23:2049-54. 2011
    ..e., an anoxic-anaerobic-aerobic system (inverted A20) and an anaerobic-anoxic-aerobic one (conventional A20) over a period from February to July 2009, during which both ..
  99. ncbi Staphylococcal enterotoxin B stimulation of BALB/c lymphocyte mitogenesis and potential relationship to the Mls response
    S Buxser
    Upjohn Company, Kalamazoo, Michigan 49001
    J Immunogenet 15:153-9. 1988
    ..When A20 cells were treated with SEB and used to stimulate BALB/c spleen cells which were not otherwise exposed to SEB, the ..
  100. ncbi Sustained NF-kappaB activity in chronic lymphocytic leukemia is independent of genetic and epigenetic alterations in the TNFAIP3 (A20) locus
    Lukas P Frenzel
    Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany
    Int J Cancer 128:2495-500. 2011
    ..Frequent mutations in the A20 locus--leading to sustained NFκB activity--could be shown to play a dominant role in development of different B-..
  101. ncbi Association of the 6q23 region with the rate of joint destruction in rheumatoid arthritis
    Hans Ulrich Scherer
    Department of Rheumatology, Leiden University Medical Centre, RC, Leiden, The Netherlands
    Ann Rheum Dis 69:567-70. 2010
    ..However, no association was found for rs10499194 in a Swedish cohort with early arthritis. This might be caused by over-representation of patients with severe disease in cohorts with longstanding RA...

Research Grants78

  1. IDENTIFICATION OF NATURALLY PROCESSED SMANSONI PEPTIDES
    Philip Loverde; Fiscal Year: 2001
    ..We had previously presented data showing that peptides eluted from MHC class II molecules of A20 cell line pulsed with NP40 extract of schistosomule stimulate a proliferative response in bulk lymph node cells ..
  2. VACCINIA DNA REPLICATION
    Paula Traktman; Fiscal Year: 2007
    ..The E9 DNA polymerase, A20 processivity factor, D4 uracil DNA glycosylase, D5 NTPase, I3 single-strand DNA binding protein, and B1 protein ..
  3. TNFAIP3 (A20) and Susceptibility to Systemic Lupus Erythematosus
    Patrick M Gaffney; Fiscal Year: 2010
    ..published work from our laboratory has identified and confirmed a convincing novel association with TNFAIP3 (A20), a critical negative regulator of NF-kB signaling...
  4. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2003
    ..Our preliminary data demonstrate that A20 promotes hepatocyte proliferation and is anti-apoptotic...
  5. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2006
    ..Our preliminary data demonstrate that A20 promotes hepatocyte proliferation and is anti-apoptotic...
  6. Immature intestinal NF-kB regulation, probiotics, and necrotizing enterocolitis
    Erika C Claud; Fiscal Year: 2010
    ..that compared to mature IEC, immature IEC have differences in regulation of both inhibitory kappaB alpha and A20 - key NF-kB down-regulatory proteins...
  7. Immature intestinal NF-kB regulation, probiotics, and necrotizing enterocolitis
    Erika C Claud; Fiscal Year: 2010
    ..that compared to mature IEC, immature IEC have differences in regulation of both inhibitory kappaB alpha and A20 - key NF-kB down-regulatory proteins...
  8. MEDIATORS AND MODIFIERS OF NF-kappaB IN INSULIN RESISTANCE
    Steven Shoelson; Fiscal Year: 2007
    ..As the subject of this proposal we also see constitutive, NF-kappaB dependent expression of A20, IKKi/epsilon, and IkappaBzeta, in fat and liver of obese/HFD rodent models...
  9. CD1 AND BCR/Fc RECEPTOR TARGETED LIGAND
    Grant Yeaman; Fiscal Year: 2001
    ..The construct will be linked to an anti-IgG2a (BCR) F(ab)2, and used to treat A20 B cells transfected with murine CDlda; galactosyl ceramide will also be examined in this system...
  10. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2009
    ..We have identified the 7-Zinc finger protein A20 as a critical component of the protective and regenerative responses of hepatocytes in that it protects ..
  11. Improved liver function and regeneration with A20
    Christiane Ferran; Fiscal Year: 2010
    ..We have identified the 7-Zinc finger protein A20 as a critical component of the protective and regenerative responses of hepatocytes in that it protects ..
  12. VACCINIA DNA REPLICATION
    Paula Traktman; Fiscal Year: 2003
    ..kinase, the D4 uracil DNA glycosylase, the I3 single stranded binding protein, the D5 DNA-independent NTPase, the A20 processivity factor, and the E9 DNA polymerase...
  13. VACCINIA DNA REPLICATION
    Paula Traktman; Fiscal Year: 2010
    ..The polymerase holoenzyme, comprised of the E9 DNA polymerase/A20 processivity factor/ D4 uracil DNA glycosylase will be the major topic of study...
  14. Activation of Macrophages in Human Autoimmune Diseases
    Lionel B Ivashkiv; Fiscal Year: 2010
    ..include linkage of ITGAM that encodes the 1M component of the 1M22 integrin, FCGR2A (Fc3RIIA), and TNFAIP3 (A20) with SLE and/or RA...
  15. CHEMOKINE ENHANCED IMMUNE THERAPY OF LYMPHOMA
    Joseph Rosenblatt; Fiscal Year: 2002
    ..transduction and the antitumor activity of the chemokines when used alone and/or in combination with CD40L in the A20 murine B-cell lymphoma model...
  16. A new approach to xenotransplantation in primate
    Juan Contreras; Fiscal Year: 2005
    ..Expression in the graft of anti-apoptotic or "protective genes", such as Bcl-2, A20 BcI-xL and heme oxygenase-1 (HO-1), make the graft resistant to rejection...
  17. Gene transfer with A20 to improve islet transplantation
    Christiane Ferran; Fiscal Year: 2003
    ..Our preliminary data reveals that A20 is part of the physiological response of islets to injury...
  18. Vascular Remodeling in Transplant Arteriosclerosis
    Christiane Ferran; Fiscal Year: 2007
    ..We have shown that A20 is part of the regulatory cytoprotective response of EC to injury...
  19. Vascular Remodeling in Transplant Arteriosclerosis
    Christiane Ferran; Fiscal Year: 2009
    ..We have shown that A20 is part of the regulatory cytoprotective response of EC to injury...
  20. CD20 DNA VACCINATION FOR B-CELL LYMPHOMA
    Maria Palomba; Fiscal Year: 2007
    ..form of the human CD20 cDNA, administered to mice via particle bombardment and followed by a lethal challenge of A20 murine lymphoma cells, resulted in cellular immune responses against the human and mouse CD20 (therefore breaking ..
  21. Mechanisms of HTLV-I Tax-mediated NF-kB activation
    Edward Harhaj; Fiscal Year: 2009
    ..of cytokine-mediated NF-kB signaling by functioning as an essential subunit for the ubiquitin-editing enzyme A20. We hypothesize that Tax targets TAX1BP1 as part of a mechanism to promote persistent NF-kB activation...
  22. Mechanisms of HTLV-I Tax-mediated NF-kB activation
    Edward W Harhaj; Fiscal Year: 2010
    ..of cytokine-mediated NF-kB signaling by functioning as an essential subunit for the ubiquitin-editing enzyme A20. We hypothesize that Tax targets TAX1BP1 as part of a mechanism to promote persistent NF-kB activation...
  23. Developing novel adjuvants for HIV vaccination
    Si Yi Chen; Fiscal Year: 2009
    ..found that the negative regulators of proinflammatory signaling, such as the zinc-finger ubiquitin-modifying enzyme A20 and suppressor of cytokine signaling 1 (SOCS1), play critical roles in limiting the immunostimulatory potency of ..
  24. Developing novel adjuvants for HIV vaccination
    Si Yi Chen; Fiscal Year: 2010
    ..found that the negative regulators of proinflammatory signaling, such as the zinc-finger ubiquitin-modifying enzyme A20 and suppressor of cytokine signaling 1 (SOCS1), play critical roles in limiting the immunostimulatory potency of ..