15 hydroxyprostaglandin dehydrogenase


Gene Symbol: 15 hydroxyprostaglandin dehydrogenase
Description: 15-hydroxyprostaglandin dehydrogenase
Alias: 15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1, 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 15-hydroxyprostaglandin dehydrogenase (NAD(+)), NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, hydroxyprostaglandin dehydrogenase 15-(NAD), prostaglandin dehydrogenase 1, short chain dehydrogenase/reductase family 36C member 1
Species: human

Top Publications

  1. Krook M, Marekov L, Jornvall H. Purification and structural characterization of placental NAD(+)-linked 15-hydroxyprostaglandin dehydrogenase. The primary structure reveals the enzyme to belong to the short-chain alcohol dehydrogenase family. Biochemistry. 1990;29:738-43 pubmed
    ..The protein has four cysteine residues (five with the positional microheterogeneity), but there is no evidence for functional importance of any of these residues.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  2. Yan M, Rerko R, Platzer P, Dawson D, Willis J, Tong M, et al. 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers. Proc Natl Acad Sci U S A. 2004;101:17468-73 pubmed
    ..prostaglandin biogenesis pathway by ubiquitously abrogating expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a prostaglandin-degrading enzyme that physiologically antagonizes COX-2...
  3. Myung S, Rerko R, Yan M, Platzer P, Guda K, Dotson A, et al. 15-Hydroxyprostaglandin dehydrogenase is an in vivo suppressor of colon tumorigenesis. Proc Natl Acad Sci U S A. 2006;103:12098-102 pubmed
    15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a prostaglandin-degrading enzyme that is highly expressed in normal colon mucosa but is ubiquitously lost in human colon cancers...
  4. Huang G, Eisenberg R, Yan M, Monti S, Lawrence E, Fu P, et al. 15-Hydroxyprostaglandin dehydrogenase is a target of hepatocyte nuclear factor 3beta and a tumor suppressor in lung cancer. Cancer Res. 2008;68:5040-8 pubmed publisher
    ..In a transcriptional profiling study using a conditional cell line system, we now identify 15-PGDH as one of the major genes induced by HNF3beta expression...
  5. Li M, Xie J, Cheng L, Chang B, Wang Y, Lan X, et al. Suppression of invasive properties of colorectal carcinoma SW480 cells by 15-hydroxyprostaglandin dehydrogenase gene. Cancer Invest. 2008;26:905-12 pubmed publisher
    ..NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), an enzyme involved in prostaglandin (including PGE(2)) bio-inactivation, is down-expressed in several epithelial ..
  6. Thiel A, Ganesan A, Mrena J, Junnila S, Nykänen A, Hemmes A, et al. 15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer. Clin Cancer Res. 2009;15:4572-80 pubmed publisher
    We have investigated the expression and regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in gastric cancer...
  7. Tatsuwaki H, Tanigawa T, Watanabe T, Machida H, Okazaki H, Yamagami H, et al. Reduction of 15-hydroxyprostaglandin dehydrogenase expression is an independent predictor of poor survival associated with enhanced cell proliferation in gastric adenocarcinoma. Cancer Sci. 2010;101:550-8 pubmed publisher
    ..We determined the correlations between pattern of expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a catabolic enzyme for biological inactivation of PGE(2), in gastric adenocarcinoma and various ..
  8. Ryu Y, Myung S, Park Y, Yang D, Song H, Jeong J, et al. Inhibition of 15-hydroxyprostaglandin dehydrogenase by Helicobacter pylori in human gastric carcinogenesis. Cancer Prev Res (Phila). 2013;6:349-59 pubmed publisher
    ..15-Hydroxyprostaglandin dehydrogenase (15-PGDH) plays a key role as a tumor suppressor in gastrointestinal cancers...
  9. Thompson C, Fink S, Lutterbaugh J, Elston R, Veigl M, Markowitz S, et al. Genetic variation in 15-hydroxyprostaglandin dehydrogenase and colon cancer susceptibility. PLoS ONE. 2013;8:e64122 pubmed publisher
    15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a metabolic antagonist of COX-2, catalyzing the degradation of inflammation mediator prostaglandin E2 (PGE2) and other prostanoids...

More Information

Publications104 found, 100 shown here

  1. Ensor C, Yang J, Okita R, Tai H. Cloning and sequence analysis of the cDNA for human placental NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase. J Biol Chem. 1990;265:14888-91 pubmed
    ..4 kilobases and the other of 2.0 kilobases. Isolation of the cDNA for 15-hydroxyprostaglandin dehydrogenase should facilitate studies on the structure, function, and regulation of this enzyme. ..
  2. Cho H, Hamza A, Zhan C, Tai H. Key NAD+-binding residues in human 15-hydroxyprostaglandin dehydrogenase. Arch Biochem Biophys. 2005;433:447-53 pubmed
    NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a member of the short-chain dehydrogenase/reductase (SDR) family, catalyzes the first step in the catabolic pathways of prostaglandins and lipoxins, and is believed to be ..
  3. Backlund M, Mann J, Holla V, Shi Q, Daikoku T, Dey S, et al. Repression of 15-hydroxyprostaglandin dehydrogenase involves histone deacetylase 2 and snail in colorectal cancer. Cancer Res. 2008;68:9331-7 pubmed publisher
    ..Enzymatic degradation of PGE(2) involves the NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). Recent reports have shown a marked diminution of 15-PGDH expression in colorectal carcinomas (CRC)...
  4. Hoeft B, Linseisen J, Beckmann L, Muller Decker K, Canzian F, Husing A, et al. Polymorphisms in fatty-acid-metabolism-related genes are associated with colorectal cancer risk. Carcinogenesis. 2010;31:466-72 pubmed publisher
    ..Our results support the key role of prostanoid signaling in colon carcinogenesis and suggest a relevance of genetic variation in fatty acid metabolism-related genes and CRC risk. ..
  5. Poole E, Hsu L, Xiao L, Kulmacz R, Carlson C, Rabinovitch P, et al. Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. Cancer Epidemiol Biomarkers Prev. 2010;19:547-57 pubmed publisher
    ..candidate and tagSNPs in PGE2 synthase (PGES), PGE2 receptors (EP2 and EP4), and prostaglandin dehydrogenase (PGDH) in a case-control study of adenomas (n = 483) versus polyp-free controls (n = 582) and examined interactions with ..
  6. Tseng Rogenski S, Gee J, Ignatoski K, Kunju L, Bucheit A, Kintner H, et al. Loss of 15-hydroxyprostaglandin dehydrogenase expression contributes to bladder cancer progression. Am J Pathol. 2010;176:1462-8 pubmed publisher
    ..to contribute to cancer progression, is inactivated by the catabolic enzyme, 15-hydroxyprostaglandin dehydrogenase (PGDH), which has tumor-suppressor activity in lung, colon, breast, and gastric cancers...
  7. Frank B, Hoeft B, Hoffmeister M, Linseisen J, Breitling L, Chang Claude J, et al. Association of hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD) variants and colorectal cancer risk. Carcinogenesis. 2011;32:190-6 pubmed publisher
    ..82, 95% CI = 0.70, 0.95, P = 0.01) as well as among smokers (OR = 0.74, 95% CI = 0.61, 0.90, P = 0.003). Yet, our data do not support the previously reported associations of HPGD tagSNPs and risk of CRC. ..
  8. Drew D, Chin S, Gilpin K, Parziale M, Pond E, Schuck M, et al. ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial. Trials. 2017;18:50 pubmed publisher
    ..This protocol is registered with the U.S. National Institutes of Health trial registry, ClinicalTrials.gov, under the identifier NCT02394769 . Registered on 16 March 2015. ..
  9. Kispert S, Schwartz T, McHowat J. Cigarette Smoke Regulates Calcium-Independent Phospholipase A2 Metabolic Pathways in Breast Cancer. Am J Pathol. 2017;187:1855-1866 pubmed publisher
    ..These studies indicate that iPLA2-dependent metabolic pathways play an important role in tumor initiation or progression in smokers, representing novel therapeutic targets for breast cancer patients who smoke. ..
  10. Kim J, Sato M, Choi J, Kim H, Yeh B, Larsen J, et al. Nuclear Receptor Expression and Function in Human Lung Cancer Pathogenesis. PLoS ONE. 2015;10:e0134842 pubmed publisher
    ..This suggests that ligand-mediated sumoylation of PPARγ plays an important role in lung cancer pathogenesis by modulating prostaglandin metabolism. ..
  11. Nakao R, Yamamoto S, Horikawa K, Yasumoto Y, Nikawa T, Mukai C, et al. Atypical expression of circadian clock genes in denervated mouse skeletal muscle. Chronobiol Int. 2015;32:486-96 pubmed publisher
    ..Our findings revealed that sciatic denervation disrupts the circadian expression of clock and clock-controlled genes either directly or indirectly via muscle atrophy in the gastrocnemius muscles of mice in a gene-specific manner. ..
  12. Dunand C, Hoffmann P, Sapin V, Blanchon L, Salomon A, Sergent F, et al. Endocrine gland-derived endothelial growth factor (EG-VEGF) is a potential novel regulator of human parturition. Biol Reprod. 2014;91:73 pubmed publisher
    ..explants collected from nonlaboring patients, EG-VEGF decreased metalloproteinase-2 and -9 activities and increased PGDH (prostaglandin-metabolizing enzyme) expression...
  13. Kumar N, Srinivasan R, Anish T, Nandakumar G, Jambulingam P. Cutaneous leishmaniasis caused by Leishmania donovani in the tribal population of the Agasthyamala Biosphere Reserve forest, Western Ghats, Kerala, India. J Med Microbiol. 2015;64:157-63 pubmed publisher
    ..The 6-phosphogluconate (6-PGDH) gene sequences of the parasite isolates from Western Ghats indicated close genetic relatedness to L...
  14. Kim T, Park J, Kim M, Ahn Y. The role of CREB3L4 in the proliferation of prostate cancer cells. Sci Rep. 2017;7:45300 pubmed publisher
    ..Thus, our study demonstrates that CREB3L4 plays a key role in PC cell proliferation, which is promoted by both AR and IRE1?. ..
  15. Rinaldi S, Catalano R, Wade J, Rossi A, Norman J. 15-epi-lipoxin A4 reduces the mortality of prematurely born pups in a mouse model of infection-induced preterm birth. Mol Hum Reprod. 2015;21:359-68 pubmed publisher
    ..These data suggest that augmenting lipoxin levels could be a useful novel therapeutic option in the treatment of PTL, protecting the fetus from the adverse effects of infection-induced preterm birth. ..
  16. Sinreih M, Anko M, Kene N, Kocbek V, Rižner T. Expression of AKR1B1, AKR1C3 and other genes of prostaglandin F2α biosynthesis and action in ovarian endometriosis tissue and in model cell lines. Chem Biol Interact. 2015;234:320-31 pubmed publisher
    ..These cell models characterized in this study will enable further investigations into the role of PGF2α in the pathophysiology of endometriosis and the involvement of AKR1B1 and AKR1C3. ..
  17. Benke P, Hidalgo R, Braffman B, Jans J, Gassen K, Sunbul R, et al. Infantile Serine Biosynthesis Defect Due to Phosphoglycerate Dehydrogenase Deficiency: Variability in Phenotype and Treatment Response, Novel Mutations, and Diagnostic Challenges. J Child Neurol. 2017;32:543-549 pubmed publisher
    ..In this report we present 6 individuals from 3 families with infantile phosphoglycerate dehydrogenase (PGDH) deficiency who presented with psychomotor delay, growth failure, microcephaly, and spasticity...
  18. Kowalewski M, Ihle S, Siemieniuch M, Gram A, Boos A, Zduńczyk S, et al. Formation of the early canine CL and the role of prostaglandin E2 (PGE2) in regulation of its function: an in vivo approach. Theriogenology. 2015;83:1038-47 pubmed publisher
    ..Additionally, the possibility of an indirect effect on PRL function arises from the increased prolactin receptor expression in response to PGE2 treatment in canine lutein cells observed in vitro. ..
  19. Du R, Fan L, Huang H, Xiang R. [Progress in genetic research on pachydermoperiostosis]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2016;33:105-7 pubmed publisher
    ..Here the genetic basis of pachydermoperiostosis and its correlation with its clinical phenotype are reviewed, which may provide a reference for basic research and clinic diagnosis for the disease. ..
  20. Hatzirodos N, Hummitzsch K, Irving Rodgers H, Rodgers R. Transcriptome comparisons identify new cell markers for theca interna and granulosa cells from small and large antral ovarian follicles. PLoS ONE. 2015;10:e0119800 pubmed publisher
    ..Many of these were stromal extracellular matrix genes. MGARP, GLDC, CHST8, GPX3 were identified as new potential markers for granulosa cells, while FBLN5, OGN, RAMP2 were significantly elevated in the theca interna. ..
  21. Huang H, Wang Y, Cao Y, Wu B, Li Y, Fan L, et al. Interleukin-6, tumor necrosis factor-alpha and receptor activator of nuclear factor kappa ligand are elevated in hypertrophic gastric mucosa of pachydermoperiostosis. Sci Rep. 2017;7:9686 pubmed publisher
    ..Moreover, celecoxib would be a considerable choice for PDP patients. We also revealed that IL-6, TNF? and RANKL may play important roles in the molecular mechanisms of gastric mucosa hyperplasia in PDP for the first time. ..
  22. Delage Mourroux R, Pichaud F, Frendo J, Pidoux E, Guliana J, Moukhtar M, et al. Cloning and sequencing of a new 15-hydroxyprostaglandin dehydrogenase related mRNA. Gene. 1997;188:143-8 pubmed
    NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type-I 15-PGDH) inactivates prostaglandins. We recently reported an mRNA sequence coding for a predicted isomer (PGDH(rI)) of this enzyme...
  23. Thill M, Fischer D, Kelling K, Hoellen F, Dittmer C, Hornemann A, et al. Expression of vitamin D receptor (VDR), cyclooxygenase-2 (COX-2) and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in benign and malignant ovarian tissue and 25-hydroxycholecalciferol (25(OH2)D3) and prostaglandin E2 (PGE2) serum level in ovarian c. J Steroid Biochem Mol Biol. 2010;121:387-90 pubmed publisher
    ..aimed to evaluate the expression of the PG metabolising enzymes COX-2 and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) compared to the vitamin D receptor (VDR) in benign and malignant ovarian tissues...
  24. Surmiak M, Kaczor M, Sanak M. Proinflammatory genes expression in granulocytes activated by native proteinase-binding fragments of anti-proteinase 3 IgG. J Physiol Pharmacol. 2015;66:609-15 pubmed
    ..Specific F(ab)(2) antibodies against PR-3 seems not a good candidate for decoy therapy of granulomatosis with polyangiitis. ..
  25. Kochel T, Reader J, Ma X, Kundu N, Fulton A. Multiple drug resistance-associated protein (MRP4) exports prostaglandin E2 (PGE2) and contributes to metastasis in basal/triple negative breast cancer. Oncotarget. 2017;8:6540-6554 pubmed publisher
    ..PGE2 levels, we evaluated the expression of COX-2/PGE2 pathway members MRP4, the prostaglandin transporter PGT, 15-PGDH (PGE2 metabolism), the prostaglandin E receptor EP4, COX-1, and COX-2 in normal, luminal, and basal breast cancer ..
  26. Pichaud F, Delage Mourroux R, Pidoux E, Jullienne A, Rousseau Merck M. Chromosomal localization of the type-I 15-PGDH gene to 4q34-q35. Hum Genet. 1997;99:279-81 pubmed
    The gene encoding the human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase, designated type-I 15-PGDH, was mapped to chromosome 4 by analyzing its segregation in a panel of human-hamster somatic cell hybrids...
  27. Smartt H, Greenhough A, Ordóñez Morán P, Talero E, Cherry C, Wallam C, et al. ?-catenin represses expression of the tumour suppressor 15-prostaglandin dehydrogenase in the normal intestinal epithelium and colorectal tumour cells. Gut. 2012;61:1306-14 pubmed publisher
    ..The recently identified colorectal tumour suppressor 15-prostaglandin dehydrogenase (15-PGDH) catalyses prostaglandin turnover and is downregulated at a very early stage in colorectal tumorigenesis; however, ..
  28. Takumi K, Nonaka G. Bacterial Cysteine-Inducible Cysteine Resistance Systems. J Bacteriol. 2016;198:1384-92 pubmed publisher
    ..by feedback inhibition of the activities of serine acetyltransferase (SAT) and 3-phosphoglycerate dehydrogenase (3-PGDH) and is also regulated at the transcriptional level by inducing the cysteine regulon using the master regulator ..
  29. Ma G, Pan B, Ren S, Guo C, Guo Y, Wei L, et al. 15-oxoeicosatetraenoic acid mediates monocyte adhesion to endothelial cell. Lipids Health Dis. 2017;16:137 pubmed publisher
    ..acid (15-oxo-ETE) was formed from 15-hydroxyprostaglandin dehydrogenase (PGDH)-mediated oxidation of 15(S)-HETE...
  30. Chalouhi N, Jabbour P, Zanaty M, Starke R, Torner J, Nakagawa D, et al. Sex Differential in 15-Hydroxyprostaglandin Dehydrogenase Levels in the Lumen of Human Intracranial Aneurysms. J Am Heart Assoc. 2017;6: pubmed publisher
    ..study was to determine whether a sex differential exists in the level of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in the lumen of human IAs...
  31. Glinton K, Benke P, Lines M, Geraghty M, Chakraborty P, Al Dirbashi O, et al. Disturbed phospholipid metabolism in serine biosynthesis defects revealed by metabolomic profiling. Mol Genet Metab. 2018;123:309-316 pubmed publisher
    ..of any of the three enzymes involved in de novo serine biosynthesis, specifically phosphoglycerate dehydrogenase (PGDH), phosphoserine aminotransferase (PSAT), and phosphoserine phosphatase (PSP)...
  32. Pichaud F, Frendo J, Delage Mourroux R, De Vernejoul M, Moukhtar M, Jullienne A. Sequence of a novel mRNA coding for a C-terminal-truncated form of human NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase. Gene. 1995;162:319-22 pubmed
    ..using the polymerase chain reaction (PCR) and NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (type-I 15-PGDH)-specific primers, RNA extracted from the HL-60 cell line. Two bands, differing in size by approx...
  33. Yüksel Konuk B, Sirmaci A, Ayten G, Ozdemir M, Aslan I, Yılmaz Turay Ü, et al. Homozygous mutations in the 15-hydroxyprostaglandin dehydrogenase gene in patients with primary hypertrophic osteoarthropathy. Rheumatol Int. 2009;30:39-43 pubmed publisher
    ..These results confirm the presence of biallelic HPGD mutations in patients with PHO in an independent series from a different population. ..
  34. Pereira C, Queirós S, Galaghar A, Sousa H, Pimentel Nunes P, Brandão C, et al. Genetic variability in key genes in prostaglandin E2 pathway (COX-2, HPGD, ABCC4 and SLCO2A1) and their involvement in colorectal cancer development. PLoS ONE. 2014;9:e92000 pubmed publisher
    ..regulated by the rates between Cyclooxygenase-2 (COX-2) biosynthesis and 15-Hydroxyprostaglandin Dehydrogenase (15-PGDH)-dependent degradation but also the steady-state levels of PGE2 in extracellular microenvironment, maintained by ..
  35. He N, Zheng H, Li P, Zhao Y, Zhang W, Song F, et al. miR-485-5p binding site SNP rs8752 in HPGD gene is associated with breast cancer risk. PLoS ONE. 2014;9:e102093 pubmed publisher
    ..Further studies are warranted to investigate the underling mechanism for this association. ..
  36. Han Y, Park J, Cha J, Jeong M, Go E, Hahm K. Endogenous conversion of ω-6 to ω-3 polyunsaturated fatty acids in fat-1 mice attenuated intestinal polyposis by either inhibiting COX-2/β-catenin signaling or activating 15-PGDH/IL-18. Int J Cancer. 2016;138:2247-56 pubmed publisher
    ..with significant inhibition of Wnt/β-catenin signaling, COX-2 and PGE2, but induced significant levels of 15-PGDH. In addition, significant induction of the inflammasome-related substrates as IL-1β and IL-18 and activation of ..
  37. Törnblom S, Patel F, Bystrom B, Giannoulias D, Malmstrom A, Sennstrom M, et al. 15-hydroxyprostaglandin dehydrogenase and cyclooxygenase 2 messenger ribonucleic acid expression and immunohistochemical localization in human cervical tissue during term and preterm labor. J Clin Endocrinol Metab. 2004;89:2909-15 pubmed
    Here we have examined the enzymes cyclooxygenase (COX)-2 and 15-hydroxyprostaglandin dehydrogenase (15-OH PGDH) in pregnant human cervix...
  38. Yao L, Han C, Song K, Zhang J, Lim K, Wu T. Omega-3 Polyunsaturated Fatty Acids Upregulate 15-PGDH Expression in Cholangiocarcinoma Cells by Inhibiting miR-26a/b Expression. Cancer Res. 2015;75:1388-98 pubmed publisher
    ..The 15-hydroxyprostaglandin dehydrogenase (15-PGDH) catalyzes oxidation of the 15(S)-hydroxyl group of PGE2, leading to its inactivation...
  39. Prima V, Kaliberova L, Kaliberov S, Curiel D, Kusmartsev S. COX2/mPGES1/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells. Proc Natl Acad Sci U S A. 2017;114:1117-1122 pubmed publisher
    ..inhibitors or genetic overexpression of PGE2-degrading enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH), resulted in reduced PD-L1 expression...
  40. Kito K, Tsutsumi K, Rai V, Theerawitaya C, Cha Um S, Yamada Kato N, et al. Isolation and functional characterization of 3-phosphoglycerate dehydrogenase involved in salt responses in sugar beet. Protoplasma. 2017;254:2305-2313 pubmed publisher
    ..b>PGDH activity was high in storage root. After salt stress, PGDH activity was increased in leaf, petiole, and root...
  41. Seira N, Yanagisawa N, Suganami A, Honda T, Wasai M, Regan J, et al. Anti-cancer Effects of MW-03, a Novel Indole Compound, by Inducing 15-Hydroxyprostaglandin Dehydrogenase and Cellular Growth Inhibition in the LS174T Human Colon Cancer Cell Line. Biol Pharm Bull. 2017;40:1806-1812 pubmed publisher
  42. Patel F, Funder J, Challis J. Mechanism of cortisol/progesterone antagonism in the regulation of 15-hydroxyprostaglandin dehydrogenase activity and messenger ribonucleic acid levels in human chorion and placental trophoblast cells at term. J Clin Endocrinol Metab. 2003;88:2922-33 pubmed
    Prostaglandin dehydrogenase (PGDH) metabolizes prostaglandins (PGs) to render them inactive. We reported previously that cortisol (F) decreases and progesterone (P(4)) maintains PGDH activity/expression in human chorion and placenta...
  43. Marentette J, Hurst R, McHowat J. Impaired Expression of Prostaglandin E2 (PGE2) Synthesis and Degradation Enzymes during Differentiation of Immortalized Urothelial Cells from Patients with Interstitial Cystitis/Painful Bladder Syndrome. PLoS ONE. 2015;10:e0129466 pubmed publisher
    ..expression of cyclooxygenase-2 (COX-2), prostaglandin E2 synthase (PGES) and 15-hydroxyprostaglandin dehydrogenase (PGDH) in human urothelial cells and in immortalized urothelial cells isolated from the bladders of IC/PBS patients or ..
  44. Ibeagha Awemu E, Li R, Ammah A, Dudemaine P, Bissonnette N, Benchaar C, et al. Transcriptome adaptation of the bovine mammary gland to diets rich in unsaturated fatty acids shows greater impact of linseed oil over safflower oil on gene expression and metabolic pathways. BMC Genomics. 2016;17:104 pubmed publisher
  45. von Hof J, Sprekeler N, Schuler G, Boos A, Kowalewski M. Uterine and placental expression of HPGD in cows during pregnancy and release of fetal membranes. Prostaglandins Other Lipid Mediat. 2017;128-129:17-26 pubmed publisher
    ..Placentomes stained primarily in fetal compartments; interplacentomal signals were observed in endometrial glandular and luminal epithelium. Results indicate that HPGD may play a role during establishment and termination of gestation. ..
  46. Li C, Singh B, Graves Deal R, Ma H, Starchenko A, Fry W, et al. Three-dimensional culture system identifies a new mode of cetuximab resistance and disease-relevant genes in colorectal cancer. Proc Natl Acad Sci U S A. 2017;114:E2852-E2861 pubmed publisher
    ..One of the most up-regulated genes in CC was the tumor suppressor 15-PGDH/HPGD, and the most up-regulated gene in SC was versican (VCAN) in 3D and xenografts...
  47. Zhao J, Wen S, Wang X, Zhang Z. Helicobacter pylori modulates cyclooxygenase-2 and 15-hydroxy prostaglandin dehydrogenase in gastric cancer. Oncol Lett. 2017;14:5519-5525 pubmed publisher
    ..Cyclooxygenase-2 (COX-2) and 15-hydroxy prostaglandin dehydrogenase (15-PGDH) are two key enzymes that regulate PGE2 synthesis and inactivation, respectively...
  48. Siena L, Cipollina C, Di Vincenzo S, Ferraro M, Bruno A, Gjomarkaj M, et al. Electrophilic derivatives of omega-3 fatty acids counteract lung cancer cell growth. Cancer Chemother Pharmacol. 2018;81:705-716 pubmed publisher
    ..Furthermore, we evaluated whether the enzyme 15-prostaglandin dehydrogenase (15-PGDH) was required for transducing the antitumor effects of DHA...
  49. Sun K, Karna S, Moon Y, Cho H, Choi C. The wound-healing effect of 7,3',4'-trimethoxyflavone through increased levels of prostaglandin E2 by 15-hydroxyprostaglandin dehydrogenase inhibition. Biotechnol Lett. 2017;39:1575-1582 pubmed publisher
    To find an inhibitor of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) that rapidly metabolises Prostaglandin E2 (PGE2) as a mediator of wound healing, we examined seven flavonoids for this role...
  50. Tong M, Tai H. 15-Hydroxyprostaglandin dehydrogenase can be induced by dexamethasone and other glucocorticoids at the therapeutic level in A549 human lung adenocarcinoma cells. Arch Biochem Biophys. 2005;435:50-5 pubmed
    Dexamethasone induced the expression of 15-PGDH in a time- and concentration-dependent manner in A549 human lung adenocarcinoma cells. Maximal induction was observed at 10nM...
  51. Tariq M, Azeem Z, Ali G, Chishti M, Ahmad W. Mutation in the HPGD gene encoding NAD+ dependent 15-hydroxyprostaglandin dehydrogenase underlies isolated congenital nail clubbing (ICNC). J Med Genet. 2009;46:14-20 pubmed publisher
    ..S193P) in exon 6 of the human HPGD gene encoding NAD(+) dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH)...
  52. Cronin S, Tomik B, Bradley D, Slowik A, Hardiman O. Screening for replication of genome-wide SNP associations in sporadic ALS. Eur J Hum Genet. 2009;17:213-8 pubmed publisher
    ..The result for DPP6 is surprising, as it has been replicated elsewhere. We discuss the possible interpretations and implications of these findings for future ALS GWA studies both within and between populations. ..
  53. Hughes D, Otani T, Yang P, Newman R, Yantiss R, Altorki N, et al. NAD+-dependent 15-hydroxyprostaglandin dehydrogenase regulates levels of bioactive lipids in non-small cell lung cancer. Cancer Prev Res (Phila). 2008;1:241-9 pubmed publisher
    ..NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH), the key enzyme responsible for metabolic inactivation of PGs, is down-regulated in various malignancies...
  54. Sun Q, Chen Z, He P, Li Y, Ding X, Huang Y, et al. Reduced Expression of Hydrogen Sulfide-Generating Enzymes Down-Regulates 15-Hydroxyprostaglandin Dehydrogenase in Chorion during Term and Preterm Labor. Am J Pathol. 2018;188:63-71 pubmed publisher
    Chorionic NAD-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) plays a pivotal role in controlling the amount of prostaglandins in the uterus and has been implicated in the process of labor...
  55. Sangha R, Walton J, Ensor C, Tai H, Challis J. Immunohistochemical localization, messenger ribonucleic acid abundance, and activity of 15-hydroxyprostaglandin dehydrogenase in placenta and fetal membranes during term and preterm labor. J Clin Endocrinol Metab. 1994;78:982-9 pubmed
    Type 1 15-hydroxyprostaglandin dehydrogenase (PGDH) is the main enzyme responsible for the metabolism of prostaglandin E2 (PGE2) and PGF2 alpha...
  56. McKeown K, Challis J. Regulation of 15-hydroxy prostaglandin dehydrogenase by corticotrophin-releasing hormone through a calcium-dependent pathway in human chorion trophoblast cells. J Clin Endocrinol Metab. 2003;88:1737-41 pubmed
    ..events, and their synthesis and metabolism are regulated by PG H synthase and 15-hydroxy-PG dehydrogenase (PGDH), respectively. Within the chorion tissue, it is the actions of PGDH that predominate...
  57. Thill M, Becker S, Fischer D, Cordes T, Hornemann A, Diedrich K, et al. Expression of prostaglandin metabolising enzymes COX-2 and 15-PGDH and VDR in human granulosa cells. Anticancer Res. 2009;29:3611-8 pubmed
    ..enzyme cyclooxygenase-2 (COX-2) and the PG inactivating enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH)...
  58. Lou L, Jing D, Lai Y, Lu Y, Li J, Wu K. 15-PGDH is reduced and induces apoptosis and cell cycle arrest in gastric carcinoma. World J Gastroenterol. 2012;18:1028-37 pubmed publisher
    To investigate the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in human gastric cancer and it's mechanism in apoptosis and cell cycle arrest...
  59. Castro Sanchez L, Agra N, Llorente Izquierdo C, Motiño O, Casado M, Bosca L, et al. Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma. Int J Biochem Cell Biol. 2013;45:2501-11 pubmed publisher
    ..pathways involving nicotinamide adenine dinucleotide (NAD(+))-dependent 15-hydroxyprostaglandin dehydrogenase (15-PGDH). 15-PGDH is a crucial enzyme responsible for the biological inactivation of PGE2...
  60. Kishore A, Owens D, Word R. Prostaglandin E2 regulates its own inactivating enzyme, 15-PGDH, by EP2 receptor-mediated cervical cell-specific mechanisms. J Clin Endocrinol Metab. 2014;99:1006-18 pubmed publisher
    ..Prior to cervical ripening at term, 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is highly expressed in the cervix and metabolizes cyclooxygenase-2-mediated increases in active prostaglandin E2 (..
  61. El Hattab A, Shaheen R, Hertecant J, Galadari H, Albaqawi B, Nabil A, et al. On the phenotypic spectrum of serine biosynthesis defects. J Inherit Metab Dis. 2016;39:373-381 pubmed publisher
    L-serine is a non-essential amino acid that is de novo synthesized via the enzymes phosphoglycerate dehydrogenase (PGDH), phosphoserine aminotransferase (PSAT), and phosphoserine phosphatase (PSP)...
  62. Bou Saab J, Bacchetta M, Chanson M. Ineffective correction of PPAR? signaling in cystic fibrosis airway epithelial cells undergoing repair. Int J Biochem Cell Biol. 2016;78:361-369 pubmed publisher
    ..The HPGD/PPAR? axis is deregulated in primary HAEC cultures from CF patients, which may impact the maturation of BCs to differentiated luminal cells. Importantly, PPAR? therapy was inefficient in correcting the CF defect. ..
  63. He Q, Chen Z, Dong Q, Zhang L, Chen D, Patel A, et al. MicroRNA-21 regulates prostaglandin E2 signaling pathway by targeting 15-hydroxyprostaglandin dehydrogenase in tongue squamous cell carcinoma. BMC Cancer. 2016;16:685 pubmed publisher
    ..We identified a number of high-confidence MRMs in OTSCC, including miR-21-HPGD regulatory module, which may play an important role in the miR-21-HPGD-PGE2 feed-forward loop that contributes to tumorigenesis. ..
  64. Tsuruta K, Mori N. Pulmonary and placental 15-hydroxyprostaglandin dehydrogenase in rat during pregnancy. Eur J Obstet Gynecol Reprod Biol. 1988;27:71-9 pubmed
    15-Hydroxyprostaglandin dehydrogenase (PGDH) in rat lung and placenta during pregnancy was examined using a photometric assay...
  65. Nandy A, Jenatschke S, Hartung B, Milde Langosch K, Bamberger A, Gellersen B. Genomic structure and transcriptional regulation of the human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene. J Mol Endocrinol. 2003;31:105-21 pubmed
    The NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) is a catabolic enzyme that controls the biological activities of prostaglandins by converting them into inactive keto-metabolites...
  66. Michelet J, Colombe L, Gautier B, Gaillard O, Benech F, Pereira R, et al. Expression of NAD+ dependent 15-hydroxyprostaglandin dehydrogenase and protection of prostaglandins in human hair follicle. Exp Dermatol. 2008;17:821-8 pubmed publisher
    NAD(+) dependent 15-hydroxyprostaglandin dehydrogenate (15-PGDH) catalyses oxidation of 15(S)-hydroxyl group of prostaglandins and as a result inactivates their physiological potential...
  67. Lim S, Cho H, Lee T, Choi C, Min Y, Kim S, et al. Impacts of cytosolic phospholipase A2, 15-prostaglandin dehydrogenase, and cyclooxygenase-2 expressions on tumor progression in colorectal cancer. Yonsei Med J. 2010;51:692-9 pubmed publisher
    ..phospholipase A2 (cPLA2), microsomal prostaglandin E2 synthase-1 (mPGES-1), and 15-prostaglandin dehydrogenase (15-PGDH) have been suggested to be related to carcinogenesis of colorectal cancer (CRC)...
  68. Niesen F, Schultz L, Jadhav A, Bhatia C, Guo K, Maloney D, et al. High-affinity inhibitors of human NAD-dependent 15-hydroxyprostaglandin dehydrogenase: mechanisms of inhibition and structure-activity relationships. PLoS ONE. 2010;5:e13719 pubmed publisher
    15-Hydroxyprostaglandin dehydrogenase (15-PGDH, EC is the key enzyme for the inactivation of prostaglandins, regulating processes such as inflammation or proliferation...
  69. Kochel T, Fulton A. Multiple drug resistance-associated protein 4 (MRP4), prostaglandin transporter (PGT), and 15-hydroxyprostaglandin dehydrogenase (15-PGDH) as determinants of PGE2 levels in cancer. Prostaglandins Other Lipid Mediat. 2015;116-117:99-103 pubmed publisher
    ..15-hydroxyprostaglandin dehydrogenase (15-PGDH) metabolizes PGE2 and silences the pathway in this manner...
  70. Wang L, Yu J, Li Y, Liu X, Zhang Z. [Genetic diagnosis for a Chinese Han family with primary hypertrophic osteoarthropathy]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015;32:213-7 pubmed publisher
    ..01), while PGE-M was significantly reduced (P<0.01) in the patient. Primary hypertrophic osteoarthropathy in this family is caused by a homozygous mutation (c.310_311delCT) in the HPGD gene. ..
  71. Yuan L, Chen L, Liao R, Lin Y, Jiang Y, Wang O, et al. A Common Mutation and a Novel Mutation in the HPGD Gene in Nine Patients with Primary Hypertrophic Osteoarthropathy. Calcif Tissue Int. 2015;97:336-42 pubmed publisher
    ..A common mutation and a novel mutation in HPGD gene were identified to be responsible for the disease, and c.310_311delCT mutation is likely to be a hot-spot mutation site for Asian PHO patients. ..
  72. Qi X, Wang Y, Hou J, Huang Y. A Single Nucleotide Polymorphism in HPGD Gene Is Associated with Prostate Cancer Risk. J Cancer. 2017;8:4083-4086 pubmed publisher
    ..767, p = 0.019). Conclusions: rs8752 in the 3'untranslated region (UTR) of the 15-hydroxyprostaglandin dehydrogenase (HPGD) gene was found to be responsible for the susceptibility to prostate cancer in Chinese individuals...
  73. Greenland K, Jantke I, Jenatschke S, Bracken K, Vinson C, Gellersen B. The human NAD+-dependent 15-hydroxyprostaglandin dehydrogenase gene promoter is controlled by Ets and activating protein-1 transcription factors and progesterone. Endocrinology. 2000;141:581-97 pubmed
    NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (PGDH) is a key catabolic enzyme in the inactivation of PGF2alpha and PGE2 and therefore serves as an important determinant in regulating their local concentrations...
  74. Sekar Y, Befus A. Protein tyrosine nitration of 15-hydroxy prostaglandin dehydrogenase in the human mast cell line LAD2. Nitric Oxide. 2012;26:74-80 pubmed publisher
    ..blot analyses with monoclonal and polyclonal antibodies we identified 15-hydroxy prostaglandin dehydrogenase (PGDH), a major prostaglandin catabolizing enzyme, as a target for nitration in LAD2...
  75. Fink S, Yang D, Barnholtz Sloan J, Ryu Y, Mikkola D, Potter J, et al. Colonic 15-PGDH levels are stable across distance and time and are not perturbed by aspirin intervention. Dig Dis Sci. 2013;58:2615-22 pubmed publisher
    15-Hydroxprostaglandin dehydrogenase (15-PGDH) mediates a colon neoplasia suppressor pathway, acting through metabolic antagonism of cyclooxygenase-mediated colon carcinogenesis...
  76. Fink S, Yamauchi M, Nishihara R, Jung S, Kuchiba A, Wu K, et al. Aspirin and the risk of colorectal cancer in relation to the expression of 15-hydroxyprostaglandin dehydrogenase (HPGD). Sci Transl Med. 2014;6:233re2 pubmed publisher
    ..Hydroxyprostaglandin dehydrogenase 15-(nicotinamide adenine dinucleotide) (15-PGDH, HPGD) is down-regulated in colorectal cancers and functions as a metabolic antagonist of PTGS2...
  77. Mehdawi L, Prasad C, Ehrnstrom R, Andersson T, Sjölander A. Non-canonical WNT5A signaling up-regulates the expression of the tumor suppressor 15-PGDH and induces differentiation of colon cancer cells. Mol Oncol. 2016;10:1415-1429 pubmed publisher
    The tumor suppressor 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is the key enzyme in prostaglandin E2 catabolism and is down-regulated in colorectal cancer (CRC) tissue...
  78. Lin J, Zhong J. Proteomic studies on anti-tumor agent ansamitocin P-3 producer Actinosynnema pretiosum in response to ammonium and isobutanol. Bioprocess Biosyst Eng. 2017;40:1133-1139 pubmed publisher
    ..Among these proteins, D-3-phosphoglycerate dehydrogenase (PGDH) and glyceraldehyde 3-phosphate dehydrogenase showed statistically significant up-regulation in ammonium vs...
  79. Nakanishi T, Tamai I. Roles of Organic Anion Transporting Polypeptide 2A1 (OATP2A1/SLCO2A1) in Regulating the Pathophysiological Actions of Prostaglandins. AAPS J. 2017;20:13 pubmed publisher
    ..Here, we review and summarize recent information on the molecular functions of OATP2A1 and on its physiological and pathological significance. ..
  80. Arima K, Komohara Y, Bu L, Tsukamoto M, Itoyama R, Miyake K, et al. Downregulation of 15-hydroxyprostaglandin dehydrogenase by interleukin-1β from activated macrophages leads to poor prognosis in pancreatic cancer. Cancer Sci. 2018;109:462-470 pubmed publisher
    ..The enzyme 15-hydroxyprostaglandin dehydrogenase (15-PGDH) degrades prostaglandin and is frequently decreased in several types of cancer; however, the molecular mechanisms ..
  81. Quidville V, Segond N, Lausson S, Frenkian M, Cohen R, Jullienne A. 15-Hydroxyprostaglandin-dehydrogenase is involved in anti-proliferative effect of non-steroidal anti-inflammatory drugs COX-1 inhibitors on a human medullary thyroid carcinoma cell line. Prostaglandins Other Lipid Mediat. 2006;81:14-30 pubmed
    ..in vivo and in vitro, decreases proliferation and increases activity of 15-hydroxyprostaglandin-dehydrogenase (15-PGDH), the PG catabolism key enzyme...
  82. Seifert W, Beninde J, Hoffmann K, Lindner T, Bassir C, Aksu F, et al. HPGD mutations cause cranioosteoarthropathy but not autosomal dominant digital clubbing. Eur J Hum Genet. 2009;17:1570-6 pubmed publisher
    ..The failure to identify any mutation in a family with an autosomal dominant type of isolated digital clubbing suggests that HPGD is not the major gene for this condition...
  83. Thill M, Fischer D, Becker S, Cordes T, Dittmer C, Diedrich K, et al. Prostaglandin metabolizing enzymes in correlation with vitamin D receptor in benign and malignant breast cell lines. Anticancer Res. 2009;29:3619-25 pubmed
    ..The PGE2 metabolizing enzyme, 15-hydroxyprostaglandin dehydrogenase (15-PGDH) is described as a tumor suppressor in cancer...
  84. Judson B, Miyaki A, Kekatpure V, Du B, Gilleaudeau P, Sullivan Whalen M, et al. UV radiation inhibits 15-hydroxyprostaglandin dehydrogenase levels in human skin: evidence of transcriptional suppression. Cancer Prev Res (Phila). 2010;3:1104-11 pubmed publisher
    ..15-Hydroxyprostaglandin deyhdrogenase (15-PGDH), a tumor suppressor gene, plays a major role in PG catabolism...
  85. Wendell S, Golin Bisello F, Wenzel S, Sobol R, Holguin F, Freeman B. 15-Hydroxyprostaglandin dehydrogenase generation of electrophilic lipid signaling mediators from hydroxy ω-3 fatty acids. J Biol Chem. 2015;290:5868-80 pubmed publisher
    ..These data reveal that 15PGDH-derived DHA metabolites are biologically active and can contribute to the salutary signaling actions of Ω-3 fatty acids. ..
  86. Mohammadi A, Yaghoobi M, Gholamhoseinian Najar A, Kalantari Khandani B, Sharifi H, Saravani M. HSP90 Inhibition Suppresses PGE2 Production via Modulating COX-2 and 15-PGDH Expression in HT-29 Colorectal Cancer Cells. Inflammation. 2016;39:1116-23 pubmed publisher
    ..We showed 15-hydroxyprostaglandin dehydrogenase (15-PGDH) expression induced by 17-AAG treatment at both mRNA and protein levels...
  87. Gascoyne D, Lyne L, Spearman H, Buffa F, Soilleux E, Banham A. Vitamin D Receptor Expression in Plasmablastic Lymphoma and Myeloma Cells Confers Susceptibility to Vitamin D. Endocrinology. 2017;158:503-515 pubmed publisher
    ..In summary, HLY-1 provides an important model of strongly plasmablastic lymphoma, and disruption of VDR pathway activity may be of therapeutic benefit in both plasmablastic lymphoma and myeloma. ..
  88. Seta V, Capri Y, Battistella M, Bagot M, Bourrat E. Pachydermoperiostosis: The value of molecular diagnosis. Ann Dermatol Venereol. 2017;144:799-803 pubmed publisher
    ..Given the genotype/phenotype correlations illustrated by these cases, it would appear useful to propose molecular diagnosis for patients presenting pachydermoperiostosis. ..
  89. Hou Y, Lin Y, Qi X, Yuan L, Liao R, Pang Q, et al. Identification of mutations in the prostaglandin transporter gene SLCO2A1 and phenotypic comparison between two subtypes of primary hypertrophic osteoarthropathy (PHO): A single-center study. Bone. 2018;106:96-102 pubmed publisher
    ..SLCO2A1), PHO is categorized into two subtypes: hypertrophic osteoarthropathy, primary, autosomal recessive 1 (PHOAR1) and hypertrophic osteoarthropathy, primary, autosomal recessive 2 (PHOAR2)...
  90. Grant G. Regulatory Mechanism of Mycobacterium tuberculosis Phosphoserine Phosphatase SerB2. Biochemistry. 2017;56:6481-6490 pubmed publisher
    ..Many organisms control the activity of the first enzyme in the pathway, d-3-phosphoglycerate dehydrogenase (PGDH), by feedback inhibition through the interaction of l-serine with the ACT domains within the enzyme...
  91. Erwich J, Keirse M. Placental localization of 15-hydroxy-prostaglandin dehydrogenase in early and term human pregnancy. Placenta. 1992;13:223-9 pubmed
    ..This is due to the presence of large quantities of the NAD(+)-linked 15-hydroxy-prostaglandin dehydrogenase (PGDH type I; EC
  92. Liu Z, Wang X, Lu Y, Han S, Zhang F, Zhai H, et al. Expression of 15-PGDH is downregulated by COX-2 in gastric cancer. Carcinogenesis. 2008;29:1219-27 pubmed publisher
    ..15-Hydroxyprostaglandin dehydrogenase [NAD(+)] (15-PGDH), a key enzyme in prostaglandin degradation, was identified as an upregulated protein in SGC7901 cells transfected ..