14 3 3 protein tau

Summary

Gene Symbol: 14 3 3 protein tau
Description: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
Alias: 14-3-3, 1C5, HS1, 14-3-3 protein theta, 14-3-3 protein T-cell, 14-3-3 protein tau, 14-3-3 theta, protein, theta, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
Species: human
Products:     14 3 3 protein tau

Top Publications

  1. Bonnefoy Berard N, Liu Y, von Willebrand M, Sung A, Elly C, Mustelin T, et al. Inhibition of phosphatidylinositol 3-kinase activity by association with 14-3-3 proteins in T cells. Proc Natl Acad Sci U S A. 1995;92:10142-6 pubmed
    ..These findings suggest that association of 14-3-3 with PI3-K in hematopoietic (and possibly other) cells regulates the enzymatic activity of PI3-K during receptor-initiated signal transduction. ..
  2. Xiao B, Smerdon S, Jones D, Dodson G, Soneji Y, Aitken A, et al. Structure of a 14-3-3 protein and implications for coordination of multiple signalling pathways. Nature. 1995;376:188-91 pubmed
    ..At the base of this channel is a 16-residue segment of 14-3-3 which has been implicated in the binding of 14-3-3 to protein kinase C. ..
  3. Hsu S, Kaipia A, Zhu L, Hsueh A. Interference of BAD (Bcl-xL/Bcl-2-associated death promoter)-induced apoptosis in mammalian cells by 14-3-3 isoforms and P11. Mol Endocrinol. 1997;11:1858-67 pubmed
  4. Brunati A, Donella Deana A, James P, Quadroni M, Contri A, Marin O, et al. Molecular features underlying the sequential phosphorylation of HS1 protein and its association with c-Fgr protein-tyrosine kinase. J Biol Chem. 1999;274:7557-64 pubmed
    The hematopoietic lineage cell-specific protein HS1 was shown to undergo a process of sequential phosphorylation both in vitro and in vivo, which is synergistically mediated by Syk and Src family protein-tyrosine kinases and essential ..
  5. Malaspina A, Kaushik N, de Belleroche J. A 14-3-3 mRNA is up-regulated in amyotrophic lateral sclerosis spinal cord. J Neurochem. 2000;75:2511-20 pubmed
    ..The localisation of 1C5 (YWHAQ) to chromosome 2 was determined and coincides with that reported for clone HS1 (EMBL accession no. X57347)...
  6. Zhao X, Ito A, Kane C, Liao T, Bolger T, Lemrow S, et al. The modular nature of histone deacetylase HDAC4 confers phosphorylation-dependent intracellular trafficking. J Biol Chem. 2001;276:35042-8 pubmed
    ..The first event is catalyzed by a yet to be identified protein kinase that promotes 14-3-3 binding, and the second event, involving protein kinases such as CaMKIV, leads to efficient nuclear export of the HDAC4.14-3-3 complex. ..
  7. Screaton R, Conkright M, Katoh Y, Best J, Canettieri G, Jeffries S, et al. The CREB coactivator TORC2 functions as a calcium- and cAMP-sensitive coincidence detector. Cell. 2004;119:61-74 pubmed
    ..Our results illustrate how a phosphatase/kinase module connects two signaling pathways in response to nutrient and hormonal cues. ..
  8. Wang B, Liu K, Lin F, Lin W. A role for 14-3-3 tau in E2F1 stabilization and DNA damage-induced apoptosis. J Biol Chem. 2004;279:54140-52 pubmed
    ..Together, these data demonstrate a novel function for 14-3-3 tau in the regulation of E2F1 protein stability and apoptosis during DNA damage. ..
  9. Kino T, Gragerov A, Valentin A, Tsopanomihalou M, Ilyina Gragerova G, Erwin Cohen R, et al. Vpr protein of human immunodeficiency virus type 1 binds to 14-3-3 proteins and facilitates complex formation with Cdc25C: implications for cell cycle arrest. J Virol. 2005;79:2780-7 pubmed
    ..These results indicate that Vpr promotes cell cycle arrest at the G(2)/M phase by facilitating association of 14-3-3 and Cdc25C independently of the latter's phosphorylation status. ..

More Information

Publications119 found, 100 shown here

  1. Geraghty K, Chen S, Harthill J, Ibrahim A, Toth R, Morrice N, et al. Regulation of multisite phosphorylation and 14-3-3 binding of AS160 in response to IGF-1, EGF, PMA and AICAR. Biochem J. 2007;407:231-41 pubmed
    ..Thus, although AS160 is a common target of insulin, IGF-1, EGF, PMA and AICAR, these stimuli induce distinctive patterns of phosphorylation and 14-3-3 binding, mediated by at least four protein kinases. ..
  2. Seimiya H, Sawada H, Muramatsu Y, Shimizu M, Ohko K, Yamane K, et al. Involvement of 14-3-3 proteins in nuclear localization of telomerase. EMBO J. 2000;19:2652-61 pubmed
    ..14-3-3 binding was not required for telomerase activity either in vitro or in cell extracts. These observations suggest that 14-3-3 enhances nuclear localization of TERT by inhibiting the CRM1 binding to the TERT NES-like motif. ..
  3. Hausser A, Link G, Hoene M, Russo C, Selchow O, Pfizenmaier K. Phospho-specific binding of 14-3-3 proteins to phosphatidylinositol 4-kinase III beta protects from dephosphorylation and stabilizes lipid kinase activity. J Cell Sci. 2006;119:3613-21 pubmed
    ..We propose that 14-3-3 proteins function as positive regulators of PI4KIIIbeta activity by protecting the lipid kinase from active site dephosphorylation, thereby ensuring a continuous supply of PtdIns(4)P at the Golgi compartment. ..
  4. Nishino T, Miyazaki M, Hoshino H, Miwa Y, Horinouchi S, Yoshida M. 14-3-3 regulates the nuclear import of class IIa histone deacetylases. Biochem Biophys Res Commun. 2008;377:852-6 pubmed publisher
    ..Phosphorylation-induced 14-3-3 binding biases the balance of nucleo-cytoplasmic shuttling toward the cytoplasm by inhibiting nuclear import. ..
  5. Wang B, Liu K, Lin H, Bellam N, Ling S, Lin W. 14-3-3Tau regulates ubiquitin-independent proteasomal degradation of p21, a novel mechanism of p21 downregulation in breast cancer. Mol Cell Biol. 2010;30:1508-27 pubmed publisher
    ..Together, the findings of our studies strongly suggest a novel oncogenic role of 14-3-3tau by downregulating p21 in breast cancer. Therefore, 14-3-3tau may be a potential therapeutic target in breast cancer. ..
  6. Nichols R, Dzamko N, Morrice N, Campbell D, Deak M, Ordureau A, et al. 14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization. Biochem J. 2010;430:393-404 pubmed publisher
    ..These results provide the first evidence suggesting that 14-3-3 regulates LRRK2 and that disruption of the interaction of LRRK2 with 14-3-3 may be linked to Parkinson's disease...
  7. Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni J, et al. 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J Cell Biol. 2002;156:817-28 pubmed
    ..These results indicate that 14-3-3 can mediate the relocalization of nuclear ligands by several mechanisms that ensure complete sequestration of the bound 14-3-3 complex in the cytoplasm. ..
  8. Soosairajah J, Maiti S, Wiggan O, Sarmiere P, Moussi N, Sarcevic B, et al. Interplay between components of a novel LIM kinase-slingshot phosphatase complex regulates cofilin. EMBO J. 2005;24:473-86 pubmed
    ..Here we define a novel ADF/cofilin phosphoregulatory complex and suggest a new mechanism for the regulation of ADF/cofilin activity in mediating changes to the actin cytoskeleton. ..
  9. Yang X, Lee W, Sobott F, Papagrigoriou E, Robinson C, Grossmann J, et al. Structural basis for protein-protein interactions in the 14-3-3 protein family. Proc Natl Acad Sci U S A. 2006;103:17237-42 pubmed
    ..These results show that the 14-3-3 proteins are adaptable structures in which internal flexibility is likely to facilitate recognition and binding of their interaction partners. ..
  10. Federspiel J, Codreanu S, Palubinsky A, Winland A, Betanzos C, McLaughlin B, et al. Assembly Dynamics and Stoichiometry of the Apoptosis Signal-regulating Kinase (ASK) Signalosome in Response to Electrophile Stress. Mol Cell Proteomics. 2016;15:1947-61 pubmed publisher
    ..This study further demonstrates the value of combining global and targeted MS approaches to interrogate multiprotein complex composition and dynamics. ..
  11. Lauterbach E. Psychotropic drug effects on gene transcriptomics relevant to Parkinson's disease. Prog Neuropsychopharmacol Biol Psychiatry. 2012;38:107-15 pubmed publisher
    ..Limitations of these findings and a research agenda to better relate them to the nigrostriatum and PD are discussed. ..
  12. Graser S, Mentrup B, Schneider D, Klein Hitpass L, Jakob F, Hofmann C. Overexpression of tissue-nonspecific alkaline phosphatase increases the expression of neurogenic differentiation markers in the human SH-SY5Y neuroblastoma cell line. Bone. 2015;79:150-61 pubmed publisher
    ..Taking this rare disease as a model may also help to dissect TNAP's role in neurodegenerative diseases and even improve future treatment of common pathologies. ..
  13. Leyk J, Goldbaum O, Noack M, Richter Landsberg C. Inhibition of HDAC6 modifies tau inclusion body formation and impairs autophagic clearance. J Mol Neurosci. 2015;55:1031-46 pubmed publisher
    ..Hence, the inhibition or dysregulation of HDAC6 contributes to stress responses and pathological processes in oligodendrocytes. ..
  14. Jones B, Penkert R, Xu B, Fan Y, Neale G, Gearhart P, et al. Binding of estrogen receptors to switch sites and regulatory elements in the immunoglobulin heavy chain locus of activated B cells suggests a direct influence of estrogen on antibody expression. Mol Immunol. 2016;77:97-102 pubmed publisher
    ..Additional peaks of ER? binding were coincident with hs1,2 and hs4 sites in the 3' regulatory region (3'RR) of the heavy chain locus...
  15. Tian K, Jiang H, Wang B, Zhang F, Han S. Intravenous injection of l-BMAA induces a rat model with comprehensive characteristics of amyotrophic lateral sclerosis/Parkinson-dementia complex. Toxicol Res (Camb). 2016;5:79-96 pubmed publisher
    ..These results suggest that this model could be used as a useful tool for the mechanistic and therapeutic study of ALS/PDC. ..
  16. Zhang C, Pang Y, Zhang Q, Huang G, Xu M, Tang B, et al. Hemolymph transcriptome analysis of Chinese mitten crab (Eriocheir sinensis) with intact, left cheliped autotomy and bilateral eyestalk ablation. Fish Shellfish Immunol. 2018;81:266-275 pubmed publisher
    ..Our research obtained abundant E. sinensis hemolymph transcriptome information by RNA-Seq, which provides multi-level information for the cloning of novel genes and the study of hemolymph molecular immunology mechanisms of E. sinensis. ..
  17. Dengler Crish C, Smith M, Wilson G. Early Evidence of Low Bone Density and Decreased Serotonergic Synthesis in the Dorsal Raphe of a Tauopathy Model of Alzheimer's Disease. J Alzheimers Dis. 2017;55:1605-1619 pubmed publisher
    ..This illuminates a need to define a mechanistic relationship between bone loss and serotonergic deficits in early AD. ..
  18. Abid N, Naseer M, Kim M. Comparative Gene-Expression Analysis of Alzheimer's Disease Progression with Aging in Transgenic Mouse Model. Int J Mol Sci. 2019;20: pubmed publisher
  19. Long L, Cai X, Wei X, Liao J, Xu Y, Gao H, et al. Progressive supranuclear palsy: what do we know about it?. Curr Med Chem. 2015;22:1182-93 pubmed
    ..PSP treatments such as serotonin antagonists, ?2 receptor antagonists, and coenzyme Q10 are also discussed. There is no curative therapy for PSP; all of the available treatments are palliative. ..
  20. Miller N, Feng Z, Edens B, Yang B, Shi H, Sze C, et al. Non-aggregating tau phosphorylation by cyclin-dependent kinase 5 contributes to motor neuron degeneration in spinal muscular atrophy. J Neurosci. 2015;35:6038-50 pubmed publisher
    ..Altogether, our findings suggest a novel mechanism for SMA pathogenesis in which hyperphosphorylation of non-aggregating tau by Cdk5 contributes to motor neuron degeneration. ..
  21. Hoque A, Williamson N, Ameen S, Ciccotosto G, Hossain M, Oakhill J, et al. Quantitative proteomic analyses of dynamic signalling events in cortical neurons undergoing excitotoxic cell death. Cell Death Dis. 2019;10:213 pubmed publisher
  22. McGorum B, Pirie R, Eaton S, Keen J, Cumyn E, Arnott D, et al. Proteomic Profiling of Cranial (Superior) Cervical Ganglia Reveals Beta-Amyloid and Ubiquitin Proteasome System Perturbations in an Equine Multiple System Neuropathy. Mol Cell Proteomics. 2015;14:3072-86 pubmed publisher
    ..Importantly, this study highlights the feasibility and benefits of applying modern proteomic techniques to veterinary investigations of neurodegenerative processes in diseases of large animals. ..
  23. Yamamoto Y, Luckenbach J, Young G, Swanson P. Alterations in gene expression during fasting-induced atresia of early secondary ovarian follicles of coho salmon, Oncorhynchus kisutch. Comp Biochem Physiol A Mol Integr Physiol. 2016;201:1-11 pubmed publisher
    ..This study revealed ovarian genes involved in normal early secondary oocyte growth and potential early markers of atresia. ..
  24. Hosaka T, Ishii K, Miura T, Mezaki N, Kasuga K, Ikeuchi T, et al. A novel frameshift GRN mutation results in frontotemporal lobar degeneration with a distinct clinical phenotype in two siblings: case report and literature review. BMC Neurol. 2017;17:182 pubmed publisher
    ..The role of progranulin has been reported in this and other neurodegenerative diseases, and the analysis of GRN mutations may lead to the discovery of a new therapeutic target. ..
  25. Zhou D, Liu H, Li C, Wang F, Shi Y, Liu L, et al. Atorvastatin ameliorates cognitive impairment, Aβ1-42 production and Tau hyperphosphorylation in APP/PS1 transgenic mice. Metab Brain Dis. 2016;31:693-703 pubmed publisher
    ..These results indicated that the memory ameliorating effect of atorvastatin may be, in part, by regulation the AKT/GSK3β signaling which may contribute to down-regulation of Aβ1-42 and tau hyperphosphorylation. ..
  26. Bou Samra E, Buhagiar Labarchède G, Machon C, Guitton J, Onclercq Delic R, Green M, et al. A role for Tau protein in maintaining ribosomal DNA stability and cytidine deaminase-deficient cell survival. Nat Commun. 2017;8:693 pubmed publisher
    ..Here the authors find a synthetic lethal interaction between CDA and the microtubule-associated protein Tau deficiencies, and report that Tau depletion affects rRNA synthesis, ribonucleotide pool balance, and rDNA stability. ..
  27. Sladeczek F, Camonis J, Burnol A, Le Bouffant F. The Cdk-like protein PCTAIRE-1 from mouse brain associates with p11 and 14-3-3 proteins. Mol Gen Genet. 1997;254:571-7 pubmed
  28. Ahmadzadeh H, Smith D, Shenoy V. Mechanical Effects of Dynamic Binding between Tau Proteins on Microtubules during Axonal Injury. Biophys J. 2015;109:2328-37 pubmed publisher
    ..Notably, the predictions from the model are in excellent agreement with the findings of the recent in vitro mechanical testing of micropatterned neuronal cultures. ..
  29. Qing Y, Sun L, Yang C, Jiang J, Yang X, Hu X, et al. Dysregulated 14-3-3 Family in Peripheral Blood Leukocytes of Patients with Schizophrenia. Sci Rep. 2016;6:23791 pubmed publisher
  30. Di J, Cohen L, Corbo C, Phillips G, El Idrissi A, Alonso A. Abnormal tau induces cognitive impairment through two different mechanisms: synaptic dysfunction and neuronal loss. Sci Rep. 2016;6:20833 pubmed publisher
    ..These findings suggest, that phosphorylated tau is sufficient to induce neurodegeneration and that two different mechanisms can induce cognitive impairment depending on the levels of PH-Tau expression. ..
  31. Lara Padilla E, Miliar Garcia A, Gomez Lopez M, Romero Morelos P, Bazan Mendez C, Alfaro Rodriguez A, et al. Neural Transdifferentiation: MAPTau Gene Expression in Breast Cancer Cells. Asian Pac J Cancer Prev. 2016;17:1967-71 pubmed
    ..In conclusion, regulation of MAP- Tau could bring about changes in cytoskeleton, cell morphology and motility; these findings cast further light on neuronal transdifferentiation in BCa. ..
  32. Oroz J, Kim J, Chang B, Zweckstetter M. Mechanistic basis for the recognition of a misfolded protein by the molecular chaperone Hsp90. Nat Struct Mol Biol. 2017;24:407-413 pubmed publisher
    ..Taken together, the data suggest that Hsp90 uses a mechanism for the recognition of aggregation-prone proteins that is largely distinct from those of other Hsp90 clients. ..
  33. Vega R, Harrison B, Meadows E, Roberts C, Papst P, Olson E, et al. Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol Cell Biol. 2004;24:8374-85 pubmed
  34. Manke I, Nguyen A, Lim D, Stewart M, Elia A, Yaffe M. MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation. Mol Cell. 2005;17:37-48 pubmed
    ..We propose that MAPKAP kinase-2 is a new member of the DNA damage checkpoint kinase family that functions in parallel with Chk1 and Chk2 to integrate DNA damage signaling responses and cell cycle arrest in mammalian cells. ..
  35. Won H, Lee K, Sung S, Choi M, Jo J, Nam E, et al. Topoisomerase II alpha and microtubule-associated protein-tau as a predictive marker in axillary lymph node positive breast cancer. Tumori. 2014;100:80-6 pubmed publisher
  36. Konakahara S, Suzuki Y, Kawakami T, Saitou M, Kajikawa M, Masuho Y, et al. A neuronal transmembrane protein LRFN4 complexes with 14-3-3s and NCK1 to induce morphological change in monocytic cells via Rac1-mediated actin cytoskeleton reorganization. FEBS Lett. 2012;586:2251-9 pubmed publisher
    ..These results indicated that LRFN4 complexed with 14-3-3s and NCK1 to mediate elongation in monocytic cells via Rac-1-mediated actin cytoskeleton reorganization. ..
  37. Wan L, Zou Y, Wan L, Wang L, Huang M, Wu J, et al. Tanshinone IIA inhibits the proliferation, migration and invasion of ectopic endometrial stromal cells of adenomyosis via 14-3-3ζ downregulation. Arch Gynecol Obstet. 2015;292:1301-9 pubmed publisher
    ..Furthermore, the effects of cell viability, migration and invasion were mediated in 14-3-3ζ-dependent manner while that of cell apoptosis was mediated in 14-3-3ζ-independent manner. ..
  38. Miki T, Yokota O, Takenoshita S, Mori Y, Yamazaki K, Ozaki Y, et al. Frontotemporal lobar degeneration due to P301L tau mutation showing apathy and severe frontal atrophy but lacking other behavioral changes: A case report and literature review. Neuropathology. 2018;38:268-280 pubmed publisher
  39. Walter J. Twenty Years of Presenilins--Important Proteins in Health and Disease. Mol Med. 2015;21 Suppl 1:S41-8 pubmed publisher
    ..Here, the progress in presenilin research from basic characterization of their cellular functions to the targeting in clinical trials for AD therapy, and potential future directions, will be discussed. ..
  40. Moghaieb R, Abdelhadi A, El Sadawy H, Allam N, Baiome B, Soliman M. Molecular identification and genetic diversity among Photorhabdus and Xenorhabdus isolates. 3 Biotech. 2017;7:6 pubmed publisher
    ..S II). Strains were identified as Photorhabdus luminescens HRM1, P. luminescens HS1, P. luminescens HP88, Xenorhabdus indica and X. nematophila ATTC19061 using 16S rDNA sequence analysis...
  41. Rosner M, Freilinger A, Hanneder M, Fujita N, Lubec G, Tsuruo T, et al. p27Kip1 localization depends on the tumor suppressor protein tuberin. Hum Mol Genet. 2007;16:1541-56 pubmed
    ..These findings demonstrate p27 localization during the mammalian cell cycle to be under the control of the tumor suppressor tuberin. ..
  42. Chin A, Toptygin D, Elam W, Schrank T, Hilser V. Phosphorylation Increases Persistence Length and End-to-End Distance of a Segment of Tau Protein. Biophys J. 2016;110:362-371 pubmed publisher
  43. Li C, Götz J. Somatodendritic accumulation of Tau in Alzheimer's disease is promoted by Fyn-mediated local protein translation. EMBO J. 2017;36:3120-3138 pubmed publisher
    ..They identify a prominent role for neuronal Fyn in integrating signal transduction pathways that lead to the somatodendritic accumulation of Tau in AD. ..
  44. Li C, Götz J. Tau-based therapies in neurodegeneration: opportunities and challenges. Nat Rev Drug Discov. 2017;: pubmed publisher
  45. Gao Y, Jiang M, Yang T, Ni J, Chen J. A Cdc2-related protein kinase hPFTAIRE1 from human brain interacting with 14-3-3 proteins. Cell Res. 2006;16:539-47 pubmed
  46. Sluchanko N, Gusev N. Oligomeric structure of 14-3-3 protein: what do we know about monomers?. FEBS Lett. 2012;586:4249-56 pubmed publisher
    ..Further investigation of the properties of monomeric 14-3-3 is important for understanding its yet poorly characterized role in different cellular processes. ..
  47. Tuerde D, Kimura T, Miyasaka T, Furusawa K, Shimozawa A, Hasegawa M, et al. Isoform-independent and -dependent phosphorylation of microtubule-associated protein tau in mouse brain during postnatal development. J Biol Chem. 2018;293:1781-1793 pubmed publisher
    ..These results show for the first time that the phosphorylation and isoform alteration of tau are regulated differently during mouse development. ..
  48. Clokie S, Cheung K, Mackie S, Marquez R, Peden A, Aitken A. BCR kinase phosphorylates 14-3-3 Tau on residue 233. FEBS J. 2005;272:3767-76 pubmed
    ..We have previously shown that these two isoforms are also phosphorylated at this site by casein kinase 1, which, in contrast to BCR, preferentially phosphorylates 14-3-3zeta. ..
  49. Zhang R, Zhang H, Lin Y, Li J, Pober J, Min W. RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation. J Biol Chem. 2007;282:14788-96 pubmed
    ..Our results demonstrate that RIP1-mediated AIP1 phosphorylation at the 14-3-3-binding site Ser-604 is essential for TNF-induced TRAF2-RIP1-AIP1-ASK1 complex formation and for the activation of ASK1-JNK/p38 apoptotic signaling. ..
  50. Frezzato F, Accordi B, Trimarco V, Gattazzo C, Martini V, Milani G, et al. Profiling B cell chronic lymphocytic leukemia by reverse phase protein array: Focus on apoptotic proteins. J Leukoc Biol. 2016;100:1061-1070 pubmed
    ..healthy controls (HS1, ?-tubulin, PKC ?/?-II Thr-638/641, p38 MAPK Thr-180/Tyr-182, NF-?B Ser-536, Bcl2 Ser-70 and Src Tyr-527); and 3) ..
  51. Mutreja Y, GAMBLIN T. Optimization of in vitro conditions to study the arachidonic acid induction of 4R isoforms of the microtubule-associated protein tau. Methods Cell Biol. 2017;141:65-88 pubmed publisher
  52. Gao C, Li X, Lam M, Liu Y, Chakraborty S, Kao H. CRM1 mediates nuclear export of HDAC7 independently of HDAC7 phosphorylation and association with 14-3-3s. FEBS Lett. 2006;580:5096-104 pubmed
    ..Taken together, these results strongly suggest that CRM1 mediated-nuclear export of HDAC7 is independent of HDAC7 phosphorylation and its association with 14-3-3s. ..
  53. Piccoli E, Rossi G, Rossi T, Pelliccioni G, D Amato I, Tagliavini F, et al. Novel PSEN1 mutations (H214N and R220P) associated with familial Alzheimer's disease identified by targeted exome sequencing. Neurobiol Aging. 2016;40:192.e7-192.e11 pubmed publisher
    ..Two variants in microtubule-associated protein tau and 1 in progranulin appeared to be benign polymorphisms, showing no major contribution of these genes to AD. ..
  54. Maphis N, Jiang S, Binder J, Wright C, Gopalan B, Lamb B, et al. Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology. Front Mol Neurosci. 2017;10:69 pubmed publisher
    ..Together, these results suggest that MECP2 is a potential novel regulator of tau pathology relevant to AD and tauopathies. ..
  55. Sudre C, Bocchetta M, Cash D, Thomas D, Woollacott I, Dick K, et al. White matter hyperintensities are seen only in GRN mutation carriers in the GENFI cohort. Neuroimage Clin. 2017;15:171-180 pubmed publisher
    ..Future studies will be useful to investigate the longitudinal evolution of WMH and their potential use as a biomarker as well as post-mortem studies investigating the histopathological nature of the lesions. ..
  56. Ito M, Urano T, Hiroi H, Momoeda M, Saito M, Hosokawa Y, et al. The progesterone-responsive gene 14-3-3? enhances the transcriptional activity of progesterone receptor in uterine cells. J Mol Endocrinol. 2012;49:193-202 pubmed publisher
    ..Moreover, by luciferase reporter assay, we demonstrated that 14-3-3? enhances the transcriptional activity of PR-B. Taken together, we propose that 14-3-3? is a P(4)-responsive gene in uterine cells that modulates P(4) signaling. ..
  57. Coupland K, Kim W, Halliday G, Hallupp M, Dobson Stone C, Kwok J. Role of the Long Non-Coding RNA MAPT-AS1 in Regulation of Microtubule Associated Protein Tau (MAPT) Expression in Parkinson's Disease. PLoS ONE. 2016;11:e0157924 pubmed publisher
    ..Our data also suggest that increased MAPT expression could be associated with disease state, but not with PD neuropathology severity. ..
  58. Yu J, Chen L, Chen Y, Hasan M, Ghia E, Zhang L, et al. Wnt5a induces ROR1 to associate with 14-3-3? for enhanced chemotaxis and proliferation of chronic lymphocytic leukemia cells. Leukemia. 2017;31:2608-2614 pubmed publisher
    ..Collectively, this study reveals that 14-3-3? plays a critical role in Wnt5a/ROR1 signaling, leading to enhanced CLL migration and proliferation. ..
  59. Castañeda A, Serrano C, Hernández Trejo J, Gutiérrez Martínez I, Montejo López W, Gómez Suárez M, et al. pVHL suppresses Akt/?-catenin-mediated cell proliferation by inhibiting 14-3-3? expression. Biochem J. 2017;474:2679-2689 pubmed publisher
    ..Thus, inhibition of Akt and 14-3-3 function efficiently reduces cell proliferation in 786-0 cells characterized by hyperactivation of ?-catenin signaling due to pVHL loss. ..
  60. Hort J, Valis M, Waberzinek G, Talab R, Glossová L, Bojar M, et al. [Proportion of tau protein to phosphorylated tau protein CSF levels in differential diagnosis of dementia]. Nervenarzt. 2008;79:891-2, 894-6, 898 pubmed publisher
    ..These proteins are important diagnostic biomarkers for CJD, especially in patients with negative 14-3-3 protein findings. ..
  61. Van der Jeugd A, Vermaercke B, Halliday G, Staufenbiel M, Götz J. Impulsivity, decreased social exploration, and executive dysfunction in a mouse model of frontotemporal dementia. Neurobiol Learn Mem. 2016;130:34-43 pubmed publisher
    ..Thus, Tau-58-2/B mice recapitulate neurological deficits of the behavioral variant of frontotemporal dementia (bvFTD), presenting them as a suitable model to test therapeutic interventions for the amelioration of this variant. ..
  62. Soler H, Dorca Arévalo J, González M, Rubio S, Ávila J, Soriano E, et al. The GABAergic septohippocampal connection is impaired in a mouse model of tauopathy. Neurobiol Aging. 2017;49:40-51 pubmed publisher
  63. Yano M, Nakamuta S, Shiota M, Endo H, Kido H. Gatekeeper role of 14-3-3tau protein in HIV-1 gp120-mediated apoptosis of human endothelial cells by inactivation of Bad. AIDS. 2007;21:911-20 pubmed
    ..The specific up-regulation of 14-3-3tau in HUVEC negatively regulated gp120/CXCR4-mediated cell death by protecting Bad dephosphorylation. ..
  64. Li C, Wen H, Wang Q, Zhang C, Jiang L, Dou Z, et al. Exercise Training Inhibits the Nogo-A/NgR1/Rho-A Signals in the Cortical Peri-infarct Area in Hypertensive Stroke Rats. Am J Phys Med Rehabil. 2015;94:1083-94 pubmed publisher
    ..Exercise training promotes axonal recovery, which is associated with functional improvement after cerebral infarction. Down-regulation of the Nogo-A/NgR1/Rho-A may mediate the axonal remodeling induced by exercise training. ..
  65. Overk C, Rockenstein E, Florio J, Cheng Q, Masliah E. Differential calcium alterations in animal models of neurodegenerative disease: Reversal by FK506. Neuroscience. 2015;310:549-60 pubmed publisher
    ..The coupling of two-photon microscopy data and statistical classifiers serves to effectively create a bioassay where the number of animals and scientific resources can be reduced without compromising the results of the experiment. ..
  66. García Escudero V, Gargini R, Martín Maestro P, Garcia E, García Escudero R, Avila J. Tau mRNA 3'UTR-to-CDS ratio is increased in Alzheimer disease. Neurosci Lett. 2017;655:101-108 pubmed publisher
    ..Our data indicate that changes in the 3'UTR-to-CDS ratio have a regulatory role in the disease. Future research should thus consider not only mRNA levels, but also the ratios between coding and non-coding regions. ..
  67. Okada N, Yabuta N, Suzuki H, Aylon Y, Oren M, Nojima H. A novel Chk1/2-Lats2-14-3-3 signaling pathway regulates P-body formation in response to UV damage. J Cell Sci. 2011;124:57-67 pubmed publisher
    ..On the basis of these findings, we propose that the Chk1/2-Lats2-14-3-3 axis identified here plays an important role in connecting DNA damage signals to P-body assembly. ..
  68. Fichou Y, Eschmann N, Keller T, Han S. Conformation-based assay of tau protein aggregation. Methods Cell Biol. 2017;141:89-112 pubmed publisher
    ..We expect this method to be applicable to other critical segments of tau and other IDPs. ..
  69. Gurusamy N, Watanabe K, Ma M, Zhang S, Muslin A, Kodama M, et al. Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes. Biol Pharm Bull. 2005;28:957-62 pubmed
    ..Our results indicate for the first time that 14-3-3 protein negatively regulates cardiac hypertrophy and fibrosis, possibly through controlling the expression of PKCbeta2 in the diabetic myocardium. ..
  70. Connor M, Azmi P, Subramaniam V, Li H, Seth A. Molecular characterization of ring finger protein 11. Mol Cancer Res. 2005;3:453-61 pubmed
    ..Disregulation of proper RNF11 function by AKT may prove to be detrimental to patient outcomes, making RNF11 a potential target for novel cancer therapeutics. ..
  71. Winge I, McKinney J, Ying M, D Santos C, Kleppe R, Knappskog P, et al. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. Biochem J. 2008;410:195-204 pubmed
    ..This indicates that 14-3-3 proteins could play a role in consolidating and strengthening the effects of phosphorylation on TPH2 and that they may be important for the regulation of serotonin function in the nervous system. ..
  72. Halskau Ø, Ying M, Baumann A, Kleppe R, Rodriguez Larrea D, Almås B, et al. Three-way interaction between 14-3-3 proteins, the N-terminal region of tyrosine hydroxylase, and negatively charged membranes. J Biol Chem. 2009;284:32758-69 pubmed publisher
    ..Our results shed light on interaction mechanisms that might be relevant for the modulation of the distribution of TH in the cytoplasm and membrane fractions and regulation of L-DOPA and dopamine synthesis. ..
  73. Clokie S, Falconer H, Mackie S, Dubois T, Aitken A. The interaction between casein kinase Ialpha and 14-3-3 is phosphorylation dependent. FEBS J. 2009;276:6971-84 pubmed publisher
    ..We also show that both fission and budding yeast CKI kinase homologues phosphorylate mammalian and budding yeast (BMH1 and BMH2) 14-3-3 at the equivalent site. ..
  74. Cockrell L, Puckett M, Goldman E, Khuri F, Fu H. Dual engagement of 14-3-3 proteins controls signal relay from ASK2 to the ASK1 signalosome. Oncogene. 2010;29:822-30 pubmed publisher
    ..Our results suggest a model in which upstream signals couple ASK2 S964 phosphorylation to the ASK1 signalosome through dual engagement of 14-3-3. ..
  75. Hoxhaj G, Najafov A, Toth R, Campbell D, Prescott A, MacKintosh C. ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase. J Cell Sci. 2012;125:4662-75 pubmed publisher
    ..Thus, ZNRF1 and ZNRF2 are new players in regulation of the ubiquitous Na(+)/K(+)ATPase that is tuned to changing demands in many physiological contexts. ..
  76. Rubenstein R, Chang B, Yue J, Chiu A, Winkler E, Puccio A, et al. Comparing Plasma Phospho Tau, Total Tau, and Phospho Tau-Total Tau Ratio as Acute and Chronic Traumatic Brain Injury Biomarkers. JAMA Neurol. 2017;74:1063-1072 pubmed publisher
    ..Microtubule-associated protein tau is an axonal phosphoprotein. To date, the presence of the hypophosphorylated tau protein (P-tau) in plasma from patients with acute TBI and chronic TBI has not been investigated...
  77. Wu G, Mu T, Gao Z, Wang J, Sy M, Li C. Prion protein is required for tumor necrosis factor α (TNFα)-triggered nuclear factor κB (NF-κB) signaling and cytokine production. J Biol Chem. 2017;292:18747-18759 pubmed publisher
    ..Our findings reveal that PrP enhances the responses to TNFα, promoting proinflammatory cytokine production, which may contribute to inflammation and tumorigenesis. ..
  78. Nagata Ohashi K, Ohta Y, Goto K, Chiba S, Mori R, Nishita M, et al. A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia. J Cell Biol. 2004;165:465-71 pubmed
  79. Merla G, Howald C, Antonarakis S, Reymond A. The subcellular localization of the ChoRE-binding protein, encoded by the Williams-Beuren syndrome critical region gene 14, is regulated by 14-3-3. Hum Mol Genet. 2004;13:1505-14 pubmed
    ..This translocation is contingent upon the ability to bind 14-3-3. Through this mechanism the 14-3-3 isotypes directly affect the WBSCR14:Mlx complexes, which activate the transcription of lipogenic genes. ..
  80. Pulina M, Rizzuto R, Brini M, Carafoli E. Inhibitory interaction of the plasma membrane Na+/Ca2+ exchangers with the 14-3-3 proteins. J Biol Chem. 2006;281:19645-54 pubmed
    ..In vitro binding experiments revealed that all three NCX isoforms interacted with multiple 14-3-3 isoforms. 14-3-3 was bound by both phosphorylated and nonphosphorylated NCX, but the phosphorylated form had much higher binding affinity. ..
  81. Kim J, Diebold B, Babior B, Knaus U, Bokoch G. Regulation of Nox1 activity via protein kinase A-mediated phosphorylation of NoxA1 and 14-3-3 binding. J Biol Chem. 2007;282:34787-800 pubmed
  82. Lin A, Greco T, Döhner K, Sodeik B, Cristea I. A proteomic perspective of inbuilt viral protein regulation: pUL46 tegument protein is targeted for degradation by ICP0 during herpes simplex virus type 1 infection. Mol Cell Proteomics. 2013;12:3237-52 pubmed publisher
    ..The concept of a structural virion protein, pUL46, performing nonstructural roles is likely to reflect a theme common to many viruses, and a better understanding of these functions will be important for developing therapeutics. ..
  83. Gao K, Tang W, Li Y, Zhang P, Wang D, Yu L, et al. Front-signal-dependent accumulation of the RHOA inhibitor FAM65B at leading edges polarizes neutrophils. J Cell Sci. 2015;128:992-1000 pubmed publisher
    ..These data together elucidate a mechanism for RHOA and pMLC polarization in stimulated neutrophils through direct inhibition of RHOA by FAM65B at the leading edge. ..
  84. Kobayashi M, Tamari K, Kitano M, Takeuchi K. A time limit for starting anti-inflammatory treatment for better improvement of olfactory dysfunction after head injury. J Neurotrauma. 2017;: pubmed publisher
    ..These findings suggest that an anti-inflammatory treatment using steroids for traumatic olfactory dysfunction may be effective if started at least by 7 days but may be ineffective at 14 days or later after head injury...
  85. Nielsen P. Primary structure of a human protein kinase regulator protein. Biochim Biophys Acta. 1991;1088:425-8 pubmed
    ..5. Alignment of putative protein sequences shows strong conservation from Drosophila to man. Several mRNA transcripts hybridizing to the cDNA are seen in human epithelial and T-cell lines and in various mouse tissues. ..
  86. Meller N, Liu Y, Collins T, Bonnefoy Berard N, Baier G, Isakov N, et al. Direct interaction between protein kinase C theta (PKC theta) and 14-3-3 tau in T cells: 14-3-3 overexpression results in inhibition of PKC theta translocation and function. Mol Cell Biol. 1996;16:5782-91 pubmed
    ..The interaction between 14-3-3 and PKC theta may represent an important general mechanism for regulating PKC-dependent signals and, more specifically, PKC theta-mediated functions during T-cell activation. ..
  87. Schurmann A, Mooney A, Sanders L, Sells M, Wang H, Reed J, et al. p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol. 2000;20:453-61 pubmed
    ..Our findings indicate that PAK inhibits the proapoptotic effects of Bad by direct phosphorylation and that PAK may play an important role in cell survival pathways. ..
  88. Stoecklin G, Stubbs T, Kedersha N, Wax S, Rigby W, Blackwell T, et al. MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO J. 2004;23:1313-24 pubmed
    ..Our data reveal the mechanism by which the p38-MAPK/MK2 kinase cascade inhibits TTP-mediated degradation of ARE-containing transcripts and thereby contributes to lipopolysaccharide-induced TNFalpha expression. ..
  89. Pan F, Means A, Liu J. Calmodulin-dependent protein kinase IV regulates nuclear export of Cabin1 during T-cell activation. EMBO J. 2005;24:2104-13 pubmed
    ..CaMKIV-mediated nuclear export of Cabin1 is likely to account for a significant part of the requirement of CaMKIV during human T-cell activation. ..
  90. Howlett K, Sakamoto K, Garnham A, Cameron Smith D, Hargreaves M. Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle. Diabetes. 2007;56:1608-14 pubmed
    ..Regulation of AS160 and interaction with 14-3-3 in skeletal muscle are influenced by resistance exercise and insulin but do not fully explain the effect of resistance exercise on whole-body insulin action. ..
  91. Singh A, Ye M, Bucur O, Zhu S, Tanya Santos M, Rabinovitz I, et al. Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT. Mol Biol Cell. 2010;21:1140-52 pubmed publisher
  92. Liu Y, Tian R, Li Y, Liu W, Cao L, Yang X, et al. The expression of seven 14-3-3 isoforms in human meningioma. Brain Res. 2010;1336:98-102 pubmed publisher
    ..In conclusion, The 14-3-3 epsilon, zeta and theta may be involved in tumorigenesis of meningioma and be efficient markers for predicting the degree of malignancy in meningioma. ..